4ORCA

Crystal structure of mammalian calcineurin
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
409
structure length
378
Chain Sequence
PPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELVFSV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/metal binding protein
molecule keywords Serine/threonine-protein phosphatase 2B catalytic subunit be
publication title Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
rcsb
source organism Homo sapiens
total genus 131
structure length 378
sequence length 409
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4orcA01
1Z2XA 4TUGA 1OI8A 1W24A 4G9JA 1S70A 4JA9A 4KKZA 2AHDA 1MF8A 3TGHA 1FJMA 1KBPA 5IOHA 2DFJA 3H64A 4O43A 1IT6A 4ORCA 2O8GA 2O8AA 4KBPA 1WAO1 4H1YP 3QFOA 1JK7A 2QFRA 4V0WA 2BQ8X 4DT2A 2NPPC 3H68A 3ICFA 3DSCA 1II7A 3K7WC 4H2IA 1Z2WA 4FCXA 5DNYA 3EGGA 1M63A 3QFMA 4JA7A 2WDDA 1WARA 3JYFA 4O4KA 2Z72A 1QFCA 3C5WC 3IVEA 1HPUA 4IL1A 2HY1A 1V73A 3H62B 4F0ZA 2WDCA 2P6BA 3KBPA 4H2GA 2CV9A 3H60A 4FBQA 4I5NC 2NXFA 1XZWA 3ZTVA 4UT3B 4UT2A 3ZU0A 2NYLC 2HYOA 4MOVA 2WDFA 4UT3A 5F3WA 2NYMC 4LACC 3K7VC 4M0VA 4MOYA 4I5LC 1G5BA 5J28A 3DW8C 4DHLA 3E7BA 4IYPC 3LL8A 4H2BA 3FGAC 4O24A 2R17A 2Z06A 4DSYA 3HVQA 4OR9A 2IAEC 2IE3C 2QJCA 4O5GA 4LTYA 3RL3A 3THOB 3N5UA 2ZBMA 1HO5A 1XM7A 2Q8UA 3IB8A 3T1IA 2Z1AA 5GTUA 3H61A 1SU1A 2KKNA 4LU9A 4V0VA 3RL5A 3CK2A 3QG5C 5JJTA 1NNWA 1UTEA 1T71A 2USHA 2WDEA 5JPEA 1USHA 4XPNA 3RL4A 4H2FA 4ZX2A 2QFPA 4Q7FA 3IVDA 3AV0A 5HPEA 2YVTA 3QFNA 2A22A 4ORAA 1S8EA 2IE4C 1T70A 2XMOA 2JOGA 5B8IA 1TCOA 3DSDA 3C9FA 4B2OA 4MP0A 3AUZA 1S3MA 4FBWA 2BCDA 3H66A 4FBKA 3H63A 3H67A 4TUIA 3P71C 3QFKA 5INBA 3IB7A 5JPFA 1HP1A 3THNA 5EQVA 1OIDA 2GJUA 2BDXA 3RQZA 1UF3A 5C1VA 2HYPA 3PSNA 1QHWA 4WWLA 1U32A 4V0XA 4ZVZA 3V4YA 3E7AA 4YKEA 1S3LA 4H1SA 4NZVA 4ORBA 3H69A 3EGHA 3GVEA 3PSOA 1S3NA 4UWQA 1OIEA 1AUIA 1S95A 4HD0A 4J6OA
chains in the Genus database with same CATH superfamily
1Z2XA 4TUGA 1OI8A 1W24A 4G9JA 1S70A 4JA9A 4KKZA 2AHDA 1MF8A 3TGHA 1FJMA 1KBPA 5IOHA 2DFJA 3H64A 4O43A 1IT6A 4ORCA 2O8GA 2O8AA 4KBPA 1WAO1 4H1YP 3QFOA 1JK7A 2QFRA 4V0WA 2BQ8X 4DT2A 2NPPC 3H68A 3ICFA 3DSCA 1II7A 3K7WC 4H2IA 1Z2WA 4FCXA 5DNYA 3EGGA 2ZOAA 1M63A 3QFMA 2DXLA 4JA7A 2WDDA 1WARA 3JYFA 4O4KA 3E0JA 2Z72A 1QFCA 3C5WC 3IVEA 1HPUA 4IL1A 2HY1A 1V73A 3H62B 4F0ZA 2WDCA 2P6BA 3KBPA 4H2GA 2CV9A 3H60A 4FBQA 4I5NC 3FLOA 2NXFA 1XZWA 3ZTVA 4UT3B 4UT2A 3ZU0A 2NYLC 2HYOA 4MOVA 2WDFA 4UT3A 5F3WA 3D03A 2NYMC 4LACC 3K7VC 4M0VA 4MOYA 4I5LC 1G5BA 5J28A 3DW8C 4DHLA 2ZO9B 3E7BA 4IYPC 3LL8A 4H2BA 3FGAC 4O24A 2R17A 2Z06A 4DSYA 3HVQA 4OR9A 2IAEC 2IE3C 2QJCA 4O5GA 4LTYA 3RL3A 3THOB 3N5UA 2ZBMA 1HO5A 1XM7A 2Q8UA 3IB8A 3T1IA 2Z1AA 5GTUA 3H61A 1SU1A 2KKNA 4LU9A 4V0VA 3RL5A 3CK2A 3QG5C 5JJTA 1NNWA 1UTEA 1T71A 2USHA 2WDEA 5JPEA 1USHA 4XPNA 3RL4A 4H2FA 4ZX2A 2QFPA 4Q7FA 3IVDA 3AV0A 5HPEA 2YVTA 3QFNA 2A22A 4ORAA 1S8EA 2IE4C 1T70A 2XMOA 2JOGA 5B8IA 1TCOA 3DSDA 3C9FA 4B2OA 2YEQA 4MP0A 3AUZA 1S3MA 4FBWA 2BCDA 3H66A 4FBKA 3H63A 3H67A 4HD0A 3P71C 3QFKA 5INBA 4TUIA 3IB7A 5JPFA 1HP1A 3THNA 5EQVA 1OIDA 2GJUA 2BDXA 3RQZA 1UF3A 5C1VA 2HYPA 3PSNA 1QHWA 4WWLA 1U32A 4V0XA 4ZVZA 3V4YA 3E7AA 4YKEA 1S3LA 4H1SA 4NZVA 4ORBA 3H69A 3EGHA 3GVEA 3PSOA 1S3NA 4UWQA 1OIEA 1AUIA 1S95A 2DXNA 4J6OA
chains in the Genus database with same CATH topology
1Z2XA 4TUGA 1OI8A 1W24A 4G9JA 1S70A 4JA9A 4KKZA 2AHDA 1MF8A 3TGHA 1FJMA 1KBPA 5IOHA 2DFJA 3H64A 4O43A 1IT6A 4ORCA 2O8GA 2O8AA 4KBPA 1WAO1 4H1YP 3QFOA 1JK7A 2QFRA 4V0WA 2BQ8X 4DT2A 2NPPC 3H68A 3ICFA 3DSCA 1II7A 3K7WC 4H2IA 1Z2WA 4FCXA 5DNYA 3EGGA 2ZOAA 1M63A 3QFMA 2DXLA 4JA7A 2WDDA 1WARA 3JYFA 4O4KA 3E0JA 2Z72A 1QFCA 3C5WC 3IVEA 1HPUA 4IL1A 2HY1A 1V73A 3H62B 4F0ZA 2WDCA 2P6BA 3KBPA 4H2GA 2CV9A 3H60A 4FBQA 4I5NC 3FLOA 2NXFA 1XZWA 3ZTVA 4UT3B 4UT2A 3ZU0A 2NYLC 2HYOA 4MOVA 2WDFA 4UT3A 5F3WA 3D03A 2NYMC 4LACC 3K7VC 4M0VA 4MOYA 4I5LC 1G5BA 5J28A 3DW8C 4DHLA 2ZO9B 3E7BA 4IYPC 3LL8A 4H2BA 3FGAC 4O24A 2R17A 2Z06A 4DSYA 3HVQA 4OR9A 2IAEC 2IE3C 2QJCA 4O5GA 4LTYA 3RL3A 3THOB 3N5UA 2ZBMA 1HO5A 1XM7A 2Q8UA 3IB8A 3T1IA 2Z1AA 5GTUA 3H61A 1SU1A 2KKNA 4LU9A 4V0VA 3RL5A 3CK2A 3QG5C 5JJTA 1NNWA 1UTEA 1T71A 2USHA 2WDEA 5JPEA 1USHA 4XPNA 3RL4A 4H2FA 4ZX2A 2QFPA 4Q7FA 3IVDA 3AV0A 5HPEA 2YVTA 3QFNA 2A22A 4ORAA 1S8EA 2IE4C 1T70A 2XMOA 2JOGA 5B8IA 1TCOA 3DSDA 3C9FA 4B2OA 2YEQA 4MP0A 3AUZA 1S3MA 4FBWA 2BCDA 3H66A 4FBKA 3H63A 3H67A 4HD0A 3P71C 3QFKA 5INBA 4TUIA 3IB7A 5JPFA 1HP1A 3THNA 5EQVA 1OIDA 2GJUA 2BDXA 3RQZA 1UF3A 5C1VA 2HYPA 3PSNA 1QHWA 4WWLA 1U32A 4V0XA 4ZVZA 3V4YA 3E7AA 4YKEA 1S3LA 4H1SA 4NZVA 4ORBA 3H69A 3EGHA 3GVEA 3PSOA 1S3NA 4UWQA 1OIEA 1AUIA 1S95A 2DXNA 4J6OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z2X A;  4TUG A;  1OI8 A;  1W24 A;  4G9J A;  1S70 A;  4JA9 A;  4KKZ A;  2AHD A;  1MF8 A;  3TGH A;  1FJM A;  1KBP A;  5IOH A;  2DFJ A;  3H64 A;  4O43 A;  1IT6 A;  4ORC A;  2O8G A;  2O8A A;  4KBP A;  1WAO 1;  4H1Y P;  3QFO A;  1JK7 A;  2QFR A;  4V0W A;  2BQ8 X;  4DT2 A;  2NPP C;  3H68 A;  3ICF A;  3DSC A;  1II7 A;  3K7W C;  4H2I A;  1Z2W A;  4FCX A;  5DNY A;  3EGG A;  1M63 A;  3QFM A;  4JA7 A;  2WDD A;  1WAR A;  3JYF A;  4O4K A;  2Z72 A;  1QFC A;  3C5W C;  3IVE A;  1HPU A;  4IL1 A;  2HY1 A;  1V73 A;  3H62 B;  4F0Z A;  2WDC A;  2P6B A;  3KBP A;  4H2G A;  2CV9 A;  3H60 A;  4FBQ A;  4I5N C;  2NXF A;  1XZW A;  3ZTV A;  4UT3 B;  4UT2 A;  3ZU0 A;  2NYL C;  2HYO A;  4MOV A;  2WDF A;  4UT3 A;  5F3W A;  2NYM C;  4LAC C;  3K7V C;  4M0V A;  4MOY A;  4I5L C;  1G5B A;  5J28 A;  3DW8 C;  4DHL A;  3E7B A;  4IYP C;  3LL8 A;  4H2B A;  3FGA C;  4O24 A;  2R17 A;  2Z06 A;  4DSY A;  3HVQ A;  4OR9 A;  2IAE C;  2IE3 C;  2QJC A;  4O5G A;  4LTY A;  3RL3 A;  3THO B;  3N5U A;  2ZBM A;  1HO5 A;  1XM7 A;  2Q8U A;  3IB8 A;  3T1I A;  2Z1A A;  5GTU A;  3H61 A;  1SU1 A;  2KKN A;  4LU9 A;  4V0V A;  3RL5 A;  3CK2 A;  3QG5 C;  5JJT A;  1NNW A;  1UTE A;  1T71 A;  2USH A;  2WDE A;  5JPE A;  1USH A;  4XPN A;  3RL4 A;  4H2F A;  4ZX2 A;  2QFP A;  4Q7F A;  3IVD A;  3AV0 A;  5HPE A;  2YVT A;  3QFN A;  2A22 A;  4ORA A;  1S8E A;  2IE4 C;  1T70 A;  2XMO A;  2JOG A;  5B8I A;  1TCO A;  3DSD A;  3C9F A;  4B2O A;  4MP0 A;  3AUZ A;  1S3M A;  4FBW A;  2BCD A;  3H66 A;  4FBK A;  3H63 A;  3H67 A;  4TUI A;  3P71 C;  3QFK A;  5INB A;  3IB7 A;  5JPF A;  1HP1 A;  3THN A;  5EQV A;  1OID A;  2GJU A;  2BDX A;  3RQZ A;  1UF3 A;  5C1V A;  2HYP A;  3PSN A;  1QHW A;  4WWL A;  1U32 A;  4V0X A;  4ZVZ A;  3V4Y A;  3E7A A;  4YKE A;  1S3L A;  4H1S A;  4NZV A;  4ORB A;  3H69 A;  3EGH A;  3GVE A;  3PSO A;  1S3N A;  4UWQ A;  1OIE A;  1AUI A;  1S95 A;  4HD0 A;  4J6O A; 
#chains in the Genus database with same CATH topology
 1Z2X A;  4TUG A;  1OI8 A;  1W24 A;  4G9J A;  1S70 A;  4JA9 A;  4KKZ A;  2AHD A;  1MF8 A;  3TGH A;  1FJM A;  1KBP A;  5IOH A;  2DFJ A;  3H64 A;  4O43 A;  1IT6 A;  4ORC A;  2O8G A;  2O8A A;  4KBP A;  1WAO 1;  4H1Y P;  3QFO A;  1JK7 A;  2QFR A;  4V0W A;  2BQ8 X;  4DT2 A;  2NPP C;  3H68 A;  3ICF A;  3DSC A;  1II7 A;  3K7W C;  4H2I A;  1Z2W A;  4FCX A;  5DNY A;  3EGG A;  2ZOA A;  1M63 A;  3QFM A;  2DXL A;  4JA7 A;  2WDD A;  1WAR A;  3JYF A;  4O4K A;  3E0J A;  2Z72 A;  1QFC A;  3C5W C;  3IVE A;  1HPU A;  4IL1 A;  2HY1 A;  1V73 A;  3H62 B;  4F0Z A;  2WDC A;  2P6B A;  3KBP A;  4H2G A;  2CV9 A;  3H60 A;  4FBQ A;  4I5N C;  3FLO A;  2NXF A;  1XZW A;  3ZTV A;  4UT3 B;  4UT2 A;  3ZU0 A;  2NYL C;  2HYO A;  4MOV A;  2WDF A;  4UT3 A;  5F3W A;  3D03 A;  2NYM C;  4LAC C;  3K7V C;  4M0V A;  4MOY A;  4I5L C;  1G5B A;  5J28 A;  3DW8 C;  4DHL A;  2ZO9 B;  3E7B A;  4IYP C;  3LL8 A;  4H2B A;  3FGA C;  4O24 A;  2R17 A;  2Z06 A;  4DSY A;  3HVQ A;  4OR9 A;  2IAE C;  2IE3 C;  2QJC A;  4O5G A;  4LTY A;  3RL3 A;  3THO B;  3N5U A;  2ZBM A;  1HO5 A;  1XM7 A;  2Q8U A;  3IB8 A;  3T1I A;  2Z1A A;  5GTU A;  3H61 A;  1SU1 A;  2KKN A;  4LU9 A;  4V0V A;  3RL5 A;  3CK2 A;  3QG5 C;  5JJT A;  1NNW A;  1UTE A;  1T71 A;  2USH A;  2WDE A;  5JPE A;  1USH A;  4XPN A;  3RL4 A;  4H2F A;  4ZX2 A;  2QFP A;  4Q7F A;  3IVD A;  3AV0 A;  5HPE A;  2YVT A;  3QFN A;  2A22 A;  4ORA A;  1S8E A;  2IE4 C;  1T70 A;  2XMO A;  2JOG A;  5B8I A;  1TCO A;  3DSD A;  3C9F A;  4B2O A;  2YEQ A;  4MP0 A;  3AUZ A;  1S3M A;  4FBW A;  2BCD A;  3H66 A;  4FBK A;  3H63 A;  3H67 A;  4HD0 A;  3P71 C;  3QFK A;  5INB A;  4TUI A;  3IB7 A;  5JPF A;  1HP1 A;  3THN A;  5EQV A;  1OID A;  2GJU A;  2BDX A;  3RQZ A;  1UF3 A;  5C1V A;  2HYP A;  3PSN A;  1QHW A;  4WWL A;  1U32 A;  4V0X A;  4ZVZ A;  3V4Y A;  3E7A A;  4YKE A;  1S3L A;  4H1S A;  4NZV A;  4ORB A;  3H69 A;  3EGH A;  3GVE A;  3PSO A;  1S3N A;  4UWQ A;  1OIE A;  1AUI A;  1S95 A;  2DXN A;  4J6O A; 
#chains in the Genus database with same CATH homology
 1Z2X A;  4TUG A;  1OI8 A;  1W24 A;  4G9J A;  1S70 A;  4JA9 A;  4KKZ A;  2AHD A;  1MF8 A;  3TGH A;  1FJM A;  1KBP A;  5IOH A;  2DFJ A;  3H64 A;  4O43 A;  1IT6 A;  4ORC A;  2O8G A;  2O8A A;  4KBP A;  1WAO 1;  4H1Y P;  3QFO A;  1JK7 A;  2QFR A;  4V0W A;  2BQ8 X;  4DT2 A;  2NPP C;  3H68 A;  3ICF A;  3DSC A;  1II7 A;  3K7W C;  4H2I A;  1Z2W A;  4FCX A;  5DNY A;  3EGG A;  2ZOA A;  1M63 A;  3QFM A;  2DXL A;  4JA7 A;  2WDD A;  1WAR A;  3JYF A;  4O4K A;  3E0J A;  2Z72 A;  1QFC A;  3C5W C;  3IVE A;  1HPU A;  4IL1 A;  2HY1 A;  1V73 A;  3H62 B;  4F0Z A;  2WDC A;  2P6B A;  3KBP A;  4H2G A;  2CV9 A;  3H60 A;  4FBQ A;  4I5N C;  3FLO A;  2NXF A;  1XZW A;  3ZTV A;  4UT3 B;  4UT2 A;  3ZU0 A;  2NYL C;  2HYO A;  4MOV A;  2WDF A;  4UT3 A;  5F3W A;  3D03 A;  2NYM C;  4LAC C;  3K7V C;  4M0V A;  4MOY A;  4I5L C;  1G5B A;  5J28 A;  3DW8 C;  4DHL A;  2ZO9 B;  3E7B A;  4IYP C;  3LL8 A;  4H2B A;  3FGA C;  4O24 A;  2R17 A;  2Z06 A;  4DSY A;  3HVQ A;  4OR9 A;  2IAE C;  2IE3 C;  2QJC A;  4O5G A;  4LTY A;  3RL3 A;  3THO B;  3N5U A;  2ZBM A;  1HO5 A;  1XM7 A;  2Q8U A;  3IB8 A;  3T1I A;  2Z1A A;  5GTU A;  3H61 A;  1SU1 A;  2KKN A;  4LU9 A;  4V0V A;  3RL5 A;  3CK2 A;  3QG5 C;  5JJT A;  1NNW A;  1UTE A;  1T71 A;  2USH A;  2WDE A;  5JPE A;  1USH A;  4XPN A;  3RL4 A;  4H2F A;  4ZX2 A;  2QFP A;  4Q7F A;  3IVD A;  3AV0 A;  5HPE A;  2YVT A;  3QFN A;  2A22 A;  4ORA A;  1S8E A;  2IE4 C;  1T70 A;  2XMO A;  2JOG A;  5B8I A;  1TCO A;  3DSD A;  3C9F A;  4B2O A;  2YEQ A;  4MP0 A;  3AUZ A;  1S3M A;  4FBW A;  2BCD A;  3H66 A;  4FBK A;  3H63 A;  3H67 A;  4HD0 A;  3P71 C;  3QFK A;  5INB A;  4TUI A;  3IB7 A;  5JPF A;  1HP1 A;  3THN A;  5EQV A;  1OID A;  2GJU A;  2BDX A;  3RQZ A;  1UF3 A;  5C1V A;  2HYP A;  3PSN A;  1QHW A;  4WWL A;  1U32 A;  4V0X A;  4ZVZ A;  3V4Y A;  3E7A A;  4YKE A;  1S3L A;  4H1S A;  4NZV A;  4ORB A;  3H69 A;  3EGH A;  3GVE A;  3PSO A;  1S3N A;  4UWQ A;  1OIE A;  1AUI A;  1S95 A;  2DXN A;  4J6O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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