3V4YA

Crystal structure of the first nuclear pp1 holoenzyme
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
293
structure length
293
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 99
structure length 293
sequence length 293
chains with identical sequence C, E, G
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2011-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3v4yA00
3H63A 5HPEA 1Z2WA 3DSCA 2QJCA 5IOHA 2XMOA 3H66A 1SU1A 3HVQA 1S8EA 1XM7A 1XZWA 1T70A 2Z06A 4DSYA 3DSDA 4H1SA 3EGHA 2HY1A 3GVEA 4JA9A 4Q7FA 3T1IA 3IB8A 3THOB 1TCOA 4UT3A 4ZX2A 2A22A 1HP1A 1Z2XA 2YVTA 4LACC 4JA7A 2KKNA 2BCDA 2O8AA 4TUIA 1JK7A 4I5NC 3H62B 2O8GA 1M63A 1S70A 4O24A 1MF8A 1S3LA 3RQZA 4MP0A 1W24A 2Z72A 3H69A 1NNWA 5DNYA 4FBKA 5EQVA 3QG5C 2WDDA 2AHDA 4H2BA 4UT2A 2BQ8X 1G5BA 2NXFA 2IE4C 2Z1AA 3H64A 4ORAA 3RL5A 3IB7A 5B8IA 1WARA 3QFKA 3H60A 4FCXA 3QFNA 3RL4A 4IL1A 1QFCA 1OIEA 1S3NA 3QFOA 1T71A 3THNA 4MOVA 3IVDA 1FJMA 4O43A 5GTUA 3TGHA 4ORCA 2WDFA 4DT2A 3H61A 4OR9A 4O4KA 2WDCA 4ORBA 1HO5A 1USHA 4MOYA 3RL3A 4FBWA 4F0ZA 2GJUA 3ZU0A 3ICFA 2BDXA 2Q8UA 2IE3C 3PSOA 3AUZA 3CK2A 3FGAC 4H1YP 4V0XA 4UT3B 4M0VA 5C1VA 1U32A 4KKZA 5INBA 4V0VA 1OI8A 1UTEA 4IYPC 3K7WC 3P71C 4KBPA 1AUIA 4LU9A 2NYLC 4NZVA 2QFRA 1KBPA 3C5WC 3K7VC 4I5LC 2WDEA 3IVEA 3V4YA 1S95A 2R17A 1QHWA 1IT6A 2CV9A 4H2IA 4ZVZA 1UF3A 4FBQA 3E7AA 4H2FA 3AV0A 1II7A 2NYMC 2HYOA 3QFMA 4O5GA 2HYPA 3KBPA 5F3WA 5JPFA 4J6OA 5J28A 3JYFA 2P6BA 4UWQA 2DFJA 3E7BA 4V0WA 3H67A 4YKEA 5JPEA 2ZBMA 1S3MA 4DHLA 3N5UA 4XPNA 2IAEC 4LTYA 4WWLA 3ZTVA 3C9FA 1V73A 4G9JA 3LL8A 2QFPA 3PSNA 3EGGA 2NPPC 4H2GA 4HD0A 5JJTA 2JOGA 3H68A 1OIDA 2USHA 4TUGA 1WAO1 1HPUA 4B2OA 3DW8C
chains in the Genus database with same CATH superfamily
3H63A 5HPEA 1Z2WA 3DSCA 2QJCA 5IOHA 2XMOA 3H66A 1SU1A 3HVQA 1S8EA 1XM7A 1XZWA 1T70A 2Z06A 4DSYA 3DSDA 4H1SA 3EGHA 2HY1A 3GVEA 4JA9A 4Q7FA 3T1IA 3IB8A 3THOB 1TCOA 4UT3A 4ZX2A 2A22A 1HP1A 1Z2XA 2YVTA 4LACC 4JA7A 2KKNA 2BCDA 2O8AA 4TUIA 1JK7A 4I5NC 3H62B 2O8GA 1M63A 1S70A 4O24A 3FLOA 1MF8A 1S3LA 3RQZA 4MP0A 1W24A 2Z72A 3H69A 1NNWA 5DNYA 4FBKA 5EQVA 3QG5C 2WDDA 2AHDA 4H2BA 4UT2A 2BQ8X 1G5BA 2NXFA 2IE4C 2Z1AA 3H64A 4ORAA 3RL5A 3IB7A 5B8IA 1WARA 3QFKA 3H60A 4FCXA 3D03A 3QFNA 3RL4A 4IL1A 1QFCA 2YEQA 1OIEA 1S3NA 3QFOA 1T71A 3THNA 4MOVA 3IVDA 1FJMA 4O43A 5GTUA 3TGHA 4ORCA 2WDFA 4DT2A 3H61A 4OR9A 4O4KA 2WDCA 4ORBA 1HO5A 1USHA 4MOYA 3RL3A 4FBWA 4F0ZA 2GJUA 3ZU0A 3ICFA 2BDXA 2Q8UA 2IE3C 3PSOA 3AUZA 3CK2A 3FGAC 4H1YP 4V0XA 4UT3B 4M0VA 5C1VA 1U32A 4KKZA 5INBA 4V0VA 1OI8A 1UTEA 4IYPC 3K7WC 3P71C 4KBPA 1AUIA 4LU9A 2NYLC 4NZVA 2QFRA 1KBPA 3C5WC 3K7VC 2ZOAA 4I5LC 2DXNA 2WDEA 3IVEA 3V4YA 1S95A 2R17A 1QHWA 1IT6A 2CV9A 4H2IA 4ZVZA 1UF3A 4FBQA 3E7AA 4H2FA 3AV0A 1II7A 2NYMC 2HYOA 3QFMA 4O5GA 2HYPA 3KBPA 5F3WA 5JPFA 4J6OA 5J28A 3JYFA 2P6BA 4UWQA 2DFJA 3E7BA 4V0WA 2ZO9B 3H67A 4YKEA 5JPEA 2ZBMA 1S3MA 4DHLA 3N5UA 4XPNA 2IAEC 4LTYA 4WWLA 3ZTVA 3C9FA 1V73A 4G9JA 3LL8A 2QFPA 3E0JA 3PSNA 3EGGA 2DXLA 2NPPC 4H2GA 4HD0A 5JJTA 2JOGA 3H68A 1OIDA 2USHA 4TUGA 1WAO1 1HPUA 4B2OA 3DW8C
chains in the Genus database with same CATH topology
3H63A 5HPEA 1Z2WA 3DSCA 2QJCA 5IOHA 2XMOA 3H66A 1SU1A 3HVQA 1S8EA 1XM7A 1XZWA 1T70A 2Z06A 4DSYA 3DSDA 4H1SA 3EGHA 2HY1A 3GVEA 4JA9A 4Q7FA 3T1IA 3IB8A 3THOB 1TCOA 4UT3A 4ZX2A 2A22A 1HP1A 1Z2XA 2YVTA 4LACC 4JA7A 2KKNA 2BCDA 2O8AA 4TUIA 1JK7A 4I5NC 3H62B 2O8GA 1M63A 1S70A 4O24A 3FLOA 1MF8A 1S3LA 3RQZA 4MP0A 1W24A 2Z72A 3H69A 1NNWA 5DNYA 4FBKA 5EQVA 3QG5C 2WDDA 2AHDA 4H2BA 4UT2A 2BQ8X 1G5BA 2NXFA 2IE4C 2Z1AA 3H64A 4ORAA 3RL5A 3IB7A 5B8IA 1WARA 3QFKA 3H60A 4FCXA 3D03A 3QFNA 3RL4A 4IL1A 1QFCA 2YEQA 1OIEA 1S3NA 3QFOA 1T71A 3THNA 4MOVA 3IVDA 1FJMA 4O43A 5GTUA 3TGHA 4ORCA 2WDFA 4DT2A 3H61A 4OR9A 4O4KA 2WDCA 4ORBA 1HO5A 1USHA 4MOYA 3RL3A 4FBWA 4F0ZA 2GJUA 3ZU0A 3ICFA 2BDXA 2Q8UA 2IE3C 3PSOA 3AUZA 3CK2A 3FGAC 4H1YP 4V0XA 4UT3B 4M0VA 5C1VA 1U32A 4KKZA 5INBA 4V0VA 1OI8A 1UTEA 4IYPC 3K7WC 3P71C 4KBPA 1AUIA 4LU9A 2NYLC 4NZVA 2QFRA 1KBPA 3C5WC 3K7VC 2ZOAA 4I5LC 2DXNA 2WDEA 3IVEA 3V4YA 1S95A 2R17A 1QHWA 1IT6A 2CV9A 4H2IA 4ZVZA 1UF3A 4FBQA 3E7AA 4H2FA 3AV0A 1II7A 2NYMC 2HYOA 3QFMA 4O5GA 2HYPA 3KBPA 5F3WA 5JPFA 4J6OA 5J28A 3JYFA 2P6BA 4UWQA 2DFJA 3E7BA 4V0WA 2ZO9B 3H67A 4YKEA 5JPEA 2ZBMA 1S3MA 4DHLA 3N5UA 4XPNA 2IAEC 4LTYA 4WWLA 3ZTVA 3C9FA 1V73A 4G9JA 3LL8A 2QFPA 3E0JA 3PSNA 3EGGA 2DXLA 2NPPC 4H2GA 4HD0A 5JJTA 2JOGA 3H68A 1OIDA 2USHA 4TUGA 1WAO1 1HPUA 4B2OA 3DW8C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H63 A;  5HPE A;  1Z2W A;  3DSC A;  2QJC A;  5IOH A;  2XMO A;  3H66 A;  1SU1 A;  3HVQ A;  1S8E A;  1XM7 A;  1XZW A;  1T70 A;  2Z06 A;  4DSY A;  3DSD A;  4H1S A;  3EGH A;  2HY1 A;  3GVE A;  4JA9 A;  4Q7F A;  3T1I A;  3IB8 A;  3THO B;  1TCO A;  4UT3 A;  4ZX2 A;  2A22 A;  1HP1 A;  1Z2X A;  2YVT A;  4LAC C;  4JA7 A;  2KKN A;  2BCD A;  2O8A A;  4TUI A;  1JK7 A;  4I5N C;  3H62 B;  2O8G A;  1M63 A;  1S70 A;  4O24 A;  1MF8 A;  1S3L A;  3RQZ A;  4MP0 A;  1W24 A;  2Z72 A;  3H69 A;  1NNW A;  5DNY A;  4FBK A;  5EQV A;  3QG5 C;  2WDD A;  2AHD A;  4H2B A;  4UT2 A;  2BQ8 X;  1G5B A;  2NXF A;  2IE4 C;  2Z1A A;  3H64 A;  4ORA A;  3RL5 A;  3IB7 A;  5B8I A;  1WAR A;  3QFK A;  3H60 A;  4FCX A;  3QFN A;  3RL4 A;  4IL1 A;  1QFC A;  1OIE A;  1S3N A;  3QFO A;  1T71 A;  3THN A;  4MOV A;  3IVD A;  1FJM A;  4O43 A;  5GTU A;  3TGH A;  4ORC A;  2WDF A;  4DT2 A;  3H61 A;  4OR9 A;  4O4K A;  2WDC A;  4ORB A;  1HO5 A;  1USH A;  4MOY A;  3RL3 A;  4FBW A;  4F0Z A;  2GJU A;  3ZU0 A;  3ICF A;  2BDX A;  2Q8U A;  2IE3 C;  3PSO A;  3AUZ A;  3CK2 A;  3FGA C;  4H1Y P;  4V0X A;  4UT3 B;  4M0V A;  5C1V A;  1U32 A;  4KKZ A;  5INB A;  4V0V A;  1OI8 A;  1UTE A;  4IYP C;  3K7W C;  3P71 C;  4KBP A;  1AUI A;  4LU9 A;  2NYL C;  4NZV A;  2QFR A;  1KBP A;  3C5W C;  3K7V C;  4I5L C;  2WDE A;  3IVE A;  3V4Y A;  1S95 A;  2R17 A;  1QHW A;  1IT6 A;  2CV9 A;  4H2I A;  4ZVZ A;  1UF3 A;  4FBQ A;  3E7A A;  4H2F A;  3AV0 A;  1II7 A;  2NYM C;  2HYO A;  3QFM A;  4O5G A;  2HYP A;  3KBP A;  5F3W A;  5JPF A;  4J6O A;  5J28 A;  3JYF A;  2P6B A;  4UWQ A;  2DFJ A;  3E7B A;  4V0W A;  3H67 A;  4YKE A;  5JPE A;  2ZBM A;  1S3M A;  4DHL A;  3N5U A;  4XPN A;  2IAE C;  4LTY A;  4WWL A;  3ZTV A;  3C9F A;  1V73 A;  4G9J A;  3LL8 A;  2QFP A;  3PSN A;  3EGG A;  2NPP C;  4H2G A;  4HD0 A;  5JJT A;  2JOG A;  3H68 A;  1OID A;  2USH A;  4TUG A;  1WAO 1;  1HPU A;  4B2O A;  3DW8 C; 
#chains in the Genus database with same CATH topology
 3H63 A;  5HPE A;  1Z2W A;  3DSC A;  2QJC A;  5IOH A;  2XMO A;  3H66 A;  1SU1 A;  3HVQ A;  1S8E A;  1XM7 A;  1XZW A;  1T70 A;  2Z06 A;  4DSY A;  3DSD A;  4H1S A;  3EGH A;  2HY1 A;  3GVE A;  4JA9 A;  4Q7F A;  3T1I A;  3IB8 A;  3THO B;  1TCO A;  4UT3 A;  4ZX2 A;  2A22 A;  1HP1 A;  1Z2X A;  2YVT A;  4LAC C;  4JA7 A;  2KKN A;  2BCD A;  2O8A A;  4TUI A;  1JK7 A;  4I5N C;  3H62 B;  2O8G A;  1M63 A;  1S70 A;  4O24 A;  3FLO A;  1MF8 A;  1S3L A;  3RQZ A;  4MP0 A;  1W24 A;  2Z72 A;  3H69 A;  1NNW A;  5DNY A;  4FBK A;  5EQV A;  3QG5 C;  2WDD A;  2AHD A;  4H2B A;  4UT2 A;  2BQ8 X;  1G5B A;  2NXF A;  2IE4 C;  2Z1A A;  3H64 A;  4ORA A;  3RL5 A;  3IB7 A;  5B8I A;  1WAR A;  3QFK A;  3H60 A;  4FCX A;  3D03 A;  3QFN A;  3RL4 A;  4IL1 A;  1QFC A;  2YEQ A;  1OIE A;  1S3N A;  3QFO A;  1T71 A;  3THN A;  4MOV A;  3IVD A;  1FJM A;  4O43 A;  5GTU A;  3TGH A;  4ORC A;  2WDF A;  4DT2 A;  3H61 A;  4OR9 A;  4O4K A;  2WDC A;  4ORB A;  1HO5 A;  1USH A;  4MOY A;  3RL3 A;  4FBW A;  4F0Z A;  2GJU A;  3ZU0 A;  3ICF A;  2BDX A;  2Q8U A;  2IE3 C;  3PSO A;  3AUZ A;  3CK2 A;  3FGA C;  4H1Y P;  4V0X A;  4UT3 B;  4M0V A;  5C1V A;  1U32 A;  4KKZ A;  5INB A;  4V0V A;  1OI8 A;  1UTE A;  4IYP C;  3K7W C;  3P71 C;  4KBP A;  1AUI A;  4LU9 A;  2NYL C;  4NZV A;  2QFR A;  1KBP A;  3C5W C;  3K7V C;  2ZOA A;  4I5L C;  2DXN A;  2WDE A;  3IVE A;  3V4Y A;  1S95 A;  2R17 A;  1QHW A;  1IT6 A;  2CV9 A;  4H2I A;  4ZVZ A;  1UF3 A;  4FBQ A;  3E7A A;  4H2F A;  3AV0 A;  1II7 A;  2NYM C;  2HYO A;  3QFM A;  4O5G A;  2HYP A;  3KBP A;  5F3W A;  5JPF A;  4J6O A;  5J28 A;  3JYF A;  2P6B A;  4UWQ A;  2DFJ A;  3E7B A;  4V0W A;  2ZO9 B;  3H67 A;  4YKE A;  5JPE A;  2ZBM A;  1S3M A;  4DHL A;  3N5U A;  4XPN A;  2IAE C;  4LTY A;  4WWL A;  3ZTV A;  3C9F A;  1V73 A;  4G9J A;  3LL8 A;  2QFP A;  3E0J A;  3PSN A;  3EGG A;  2DXL A;  2NPP C;  4H2G A;  4HD0 A;  5JJT A;  2JOG A;  3H68 A;  1OID A;  2USH A;  4TUG A;  1WAO 1;  1HPU A;  4B2O A;  3DW8 C; 
#chains in the Genus database with same CATH homology
 3H63 A;  5HPE A;  1Z2W A;  3DSC A;  2QJC A;  5IOH A;  2XMO A;  3H66 A;  1SU1 A;  3HVQ A;  1S8E A;  1XM7 A;  1XZW A;  1T70 A;  2Z06 A;  4DSY A;  3DSD A;  4H1S A;  3EGH A;  2HY1 A;  3GVE A;  4JA9 A;  4Q7F A;  3T1I A;  3IB8 A;  3THO B;  1TCO A;  4UT3 A;  4ZX2 A;  2A22 A;  1HP1 A;  1Z2X A;  2YVT A;  4LAC C;  4JA7 A;  2KKN A;  2BCD A;  2O8A A;  4TUI A;  1JK7 A;  4I5N C;  3H62 B;  2O8G A;  1M63 A;  1S70 A;  4O24 A;  3FLO A;  1MF8 A;  1S3L A;  3RQZ A;  4MP0 A;  1W24 A;  2Z72 A;  3H69 A;  1NNW A;  5DNY A;  4FBK A;  5EQV A;  3QG5 C;  2WDD A;  2AHD A;  4H2B A;  4UT2 A;  2BQ8 X;  1G5B A;  2NXF A;  2IE4 C;  2Z1A A;  3H64 A;  4ORA A;  3RL5 A;  3IB7 A;  5B8I A;  1WAR A;  3QFK A;  3H60 A;  4FCX A;  3D03 A;  3QFN A;  3RL4 A;  4IL1 A;  1QFC A;  2YEQ A;  1OIE A;  1S3N A;  3QFO A;  1T71 A;  3THN A;  4MOV A;  3IVD A;  1FJM A;  4O43 A;  5GTU A;  3TGH A;  4ORC A;  2WDF A;  4DT2 A;  3H61 A;  4OR9 A;  4O4K A;  2WDC A;  4ORB A;  1HO5 A;  1USH A;  4MOY A;  3RL3 A;  4FBW A;  4F0Z A;  2GJU A;  3ZU0 A;  3ICF A;  2BDX A;  2Q8U A;  2IE3 C;  3PSO A;  3AUZ A;  3CK2 A;  3FGA C;  4H1Y P;  4V0X A;  4UT3 B;  4M0V A;  5C1V A;  1U32 A;  4KKZ A;  5INB A;  4V0V A;  1OI8 A;  1UTE A;  4IYP C;  3K7W C;  3P71 C;  4KBP A;  1AUI A;  4LU9 A;  2NYL C;  4NZV A;  2QFR A;  1KBP A;  3C5W C;  3K7V C;  2ZOA A;  4I5L C;  2DXN A;  2WDE A;  3IVE A;  3V4Y A;  1S95 A;  2R17 A;  1QHW A;  1IT6 A;  2CV9 A;  4H2I A;  4ZVZ A;  1UF3 A;  4FBQ A;  3E7A A;  4H2F A;  3AV0 A;  1II7 A;  2NYM C;  2HYO A;  3QFM A;  4O5G A;  2HYP A;  3KBP A;  5F3W A;  5JPF A;  4J6O A;  5J28 A;  3JYF A;  2P6B A;  4UWQ A;  2DFJ A;  3E7B A;  4V0W A;  2ZO9 B;  3H67 A;  4YKE A;  5JPE A;  2ZBM A;  1S3M A;  4DHL A;  3N5U A;  4XPN A;  2IAE C;  4LTY A;  4WWL A;  3ZTV A;  3C9F A;  1V73 A;  4G9J A;  3LL8 A;  2QFP A;  3E0J A;  3PSN A;  3EGG A;  2DXL A;  2NPP C;  4H2G A;  4HD0 A;  5JJT A;  2JOG A;  3H68 A;  1OID A;  2USH A;  4TUG A;  1WAO 1;  1HPU A;  4B2O A;  3DW8 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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