1MF8A

Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
352
structure length
352
Chain Sequence
AVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin
pubmed doi rcsb
molecule tags Hydrolase/isomerase/immunosuppressant
source organism Homo sapiens
molecule keywords CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM
total genus 121
structure length 352
sequence length 352
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2002-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1mf8A00
3AV0A 4IYPC 4LU9A 4OR9A 4M0VA 1JK7A 2YVTA 2WDDA 4G9JA 3QFKA 1HP1A 1T71A 4TUGA 3H64A 2QFPA 4V0WA 4O43A 1HO5A 2P6BA 3K7VC 4LTYA 3ZU0A 1S3LA 3DW8C 1U32A 3ICFA 2R17A 4UT2A 4IL1A 1QFCA 3DSDA 3V4YA 5F3WA 3DSCA 2Z72A 4H2GA 5JJTA 3EGGA 1HPUA 3AUZA 5J28A 3IB8A 3IVDA 3PSNA 1UTEA 2NYLC 3TGHA 2WDEA 2USHA 1S95A 3E7AA 3THOB 4DSYA 2IAEC 1TCOA 3HVQA 4B2OA 4YKEA 4H1SA 4UWQA 2QJCA 5B8IA 3H63A 3T1IA 2CV9A 2NXFA 4FBKA 2BQ8X 2KKNA 4ORCA 3RL3A 2Z1AA 3QG5C 4JA9A 1MF8A 4ORAA 1S8EA 4FBWA 4FBQA 4WWLA 5IOHA 1G5BA 1AUIA 3IVEA 3JYFA 4ORBA 3THNA 1Z2WA 1OIDA 2IE3C 4KBPA 2QFRA 2Q8UA 3C5WC 3KBPA 3GVEA 1NNWA 2HY1A 4UT3B 1W24A 2Z06A 3FGAC 1UF3A 3QFOA 4DT2A 1USHA 3H61A 2IE4C 4ZX2A 1S3MA 1T70A 5JPEA 1V73A 3H66A 3QFNA 4MOVA 1XZWA 4H1YP 3CK2A 1OI8A 2GJUA 2HYPA 4LACC 2DFJA 3H69A 3H60A 1WAO1 1QHWA 2WDFA 3P71C 4O24A 4ZVZA 3QFMA 3E7BA 4H2BA 1WARA 1M63A 3K7WC 5GTUA 3LL8A 1S3NA 5HPEA 5INBA 2WDCA 4XPNA 4MP0A 3EGHA 1FJMA 4FCXA 3ZTVA 3H67A 4H2FA 5EQVA 4TUIA 4O5GA 4V0XA 1KBPA 2O8AA 3RL4A 5DNYA 4I5LC 3RL5A 3IB7A 4NZVA 2ZBMA 4V0VA 4MOYA 3H68A 2BCDA 4J6OA 1IT6A 2A22A 4KKZA 3N5UA 4HD0A 5JPFA 2AHDA 1SU1A 3C9FA 3H62B 4Q7FA 4I5NC 4H2IA 2NYMC 1II7A 1OIEA 3PSOA 4O4KA 1XM7A 5C1VA 2NPPC 4JA7A 2BDXA 2JOGA 1Z2XA 2XMOA 4UT3A 1S70A 4F0ZA 2O8GA 3RQZA 2HYOA 4DHLA
chains in the Genus database with same CATH superfamily
3AV0A 4IYPC 4LU9A 4OR9A 4M0VA 1JK7A 2YVTA 2WDDA 4G9JA 2ZO9B 3QFKA 1HP1A 1T71A 4TUGA 3H64A 2QFPA 4V0WA 4O43A 1HO5A 2P6BA 3K7VC 4LTYA 3ZU0A 1S3LA 3DW8C 1U32A 3ICFA 2R17A 4UT2A 4IL1A 1QFCA 3DSDA 3V4YA 5F3WA 3DSCA 2Z72A 4H2GA 5JJTA 3EGGA 1HPUA 3AUZA 5J28A 3IB8A 3IVDA 3PSNA 1UTEA 2NYLC 3TGHA 2WDEA 3D03A 2USHA 1S95A 3E7AA 3THOB 4DSYA 2IAEC 1TCOA 3HVQA 4B2OA 4YKEA 4H1SA 4UWQA 2QJCA 5B8IA 2YEQA 3H63A 3T1IA 2CV9A 2NXFA 4FBKA 2BQ8X 2KKNA 3FLOA 4ORCA 3RL3A 2Z1AA 3QG5C 4JA9A 1MF8A 4ORAA 1S8EA 4FBWA 4FBQA 4WWLA 5IOHA 1G5BA 1AUIA 3IVEA 3JYFA 4ORBA 3THNA 1Z2WA 1OIDA 2IE3C 4KBPA 2QFRA 2Q8UA 3C5WC 3KBPA 3GVEA 1NNWA 2HY1A 4UT3B 1W24A 2Z06A 3FGAC 1UF3A 3QFOA 4DT2A 1USHA 3H61A 2IE4C 4ZX2A 1S3MA 1T70A 5JPEA 1V73A 3H66A 3QFNA 4MOVA 1XZWA 4H1YP 3CK2A 1OI8A 2GJUA 2HYPA 4LACC 2DFJA 3H69A 3E0JA 3H60A 1WAO1 1QHWA 2WDFA 3P71C 4O24A 4ZVZA 3QFMA 3E7BA 4H2BA 1WARA 1M63A 3K7WC 5GTUA 3LL8A 1S3NA 5HPEA 5INBA 2WDCA 4XPNA 2ZOAA 4MP0A 3EGHA 1FJMA 4FCXA 3ZTVA 3H67A 4H2FA 5EQVA 4TUIA 4O5GA 4V0XA 1KBPA 2O8AA 3RL4A 5DNYA 4I5LC 3RL5A 3IB7A 4NZVA 2ZBMA 4V0VA 4MOYA 3H68A 2BCDA 4J6OA 1IT6A 2A22A 4KKZA 2DXLA 3N5UA 4HD0A 2DXNA 5JPFA 2AHDA 1SU1A 3C9FA 3H62B 4Q7FA 4I5NC 4H2IA 2NYMC 1II7A 1OIEA 3PSOA 4O4KA 1XM7A 5C1VA 2NPPC 4JA7A 2BDXA 2JOGA 1Z2XA 2XMOA 4UT3A 1S70A 4F0ZA 2O8GA 3RQZA 2HYOA 4DHLA
chains in the Genus database with same CATH topology
3AV0A 4IYPC 4LU9A 4OR9A 4M0VA 1JK7A 2YVTA 2WDDA 4G9JA 2ZO9B 3QFKA 1HP1A 1T71A 4TUGA 3H64A 2QFPA 4V0WA 4O43A 1HO5A 2P6BA 3K7VC 4LTYA 3ZU0A 1S3LA 3DW8C 1U32A 3ICFA 2R17A 4UT2A 4IL1A 1QFCA 3DSDA 3V4YA 5F3WA 3DSCA 2Z72A 4H2GA 5JJTA 3EGGA 1HPUA 3AUZA 5J28A 3IB8A 3IVDA 3PSNA 1UTEA 2NYLC 3TGHA 2WDEA 3D03A 2USHA 1S95A 3E7AA 3THOB 4DSYA 2IAEC 1TCOA 3HVQA 4B2OA 4YKEA 4H1SA 4UWQA 2QJCA 5B8IA 2YEQA 3H63A 3T1IA 2CV9A 2NXFA 4FBKA 2BQ8X 2KKNA 3FLOA 4ORCA 3RL3A 2Z1AA 3QG5C 4JA9A 1MF8A 4ORAA 1S8EA 4FBWA 4FBQA 4WWLA 5IOHA 1G5BA 1AUIA 3IVEA 3JYFA 4ORBA 3THNA 1Z2WA 1OIDA 2IE3C 4KBPA 2QFRA 2Q8UA 3C5WC 3KBPA 3GVEA 1NNWA 2HY1A 4UT3B 1W24A 2Z06A 3FGAC 1UF3A 3QFOA 4DT2A 1USHA 3H61A 2IE4C 4ZX2A 1S3MA 1T70A 5JPEA 1V73A 3H66A 3QFNA 4MOVA 1XZWA 4H1YP 3CK2A 1OI8A 2GJUA 2HYPA 4LACC 2DFJA 3H69A 3E0JA 3H60A 1WAO1 1QHWA 2WDFA 3P71C 4O24A 4ZVZA 3QFMA 3E7BA 4H2BA 1WARA 1M63A 3K7WC 5GTUA 3LL8A 1S3NA 5HPEA 5INBA 2WDCA 4XPNA 2ZOAA 4MP0A 3EGHA 1FJMA 4FCXA 3ZTVA 3H67A 4H2FA 5EQVA 4TUIA 4O5GA 4V0XA 1KBPA 2O8AA 3RL4A 5DNYA 4I5LC 3RL5A 3IB7A 4NZVA 2ZBMA 4V0VA 4MOYA 3H68A 2BCDA 4J6OA 1IT6A 2A22A 4KKZA 2DXLA 3N5UA 4HD0A 2DXNA 5JPFA 2AHDA 1SU1A 3C9FA 3H62B 4Q7FA 4I5NC 4H2IA 2NYMC 1II7A 1OIEA 3PSOA 4O4KA 1XM7A 5C1VA 2NPPC 4JA7A 2BDXA 2JOGA 1Z2XA 2XMOA 4UT3A 1S70A 4F0ZA 2O8GA 3RQZA 2HYOA 4DHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AV0 A;  4IYP C;  4LU9 A;  4OR9 A;  4M0V A;  1JK7 A;  2YVT A;  2WDD A;  4G9J A;  3QFK A;  1HP1 A;  1T71 A;  4TUG A;  3H64 A;  2QFP A;  4V0W A;  4O43 A;  1HO5 A;  2P6B A;  3K7V C;  4LTY A;  3ZU0 A;  1S3L A;  3DW8 C;  1U32 A;  3ICF A;  2R17 A;  4UT2 A;  4IL1 A;  1QFC A;  3DSD A;  3V4Y A;  5F3W A;  3DSC A;  2Z72 A;  4H2G A;  5JJT A;  3EGG A;  1HPU A;  3AUZ A;  5J28 A;  3IB8 A;  3IVD A;  3PSN A;  1UTE A;  2NYL C;  3TGH A;  2WDE A;  2USH A;  1S95 A;  3E7A A;  3THO B;  4DSY A;  2IAE C;  1TCO A;  3HVQ A;  4B2O A;  4YKE A;  4H1S A;  4UWQ A;  2QJC A;  5B8I A;  3H63 A;  3T1I A;  2CV9 A;  2NXF A;  4FBK A;  2BQ8 X;  2KKN A;  4ORC A;  3RL3 A;  2Z1A A;  3QG5 C;  4JA9 A;  1MF8 A;  4ORA A;  1S8E A;  4FBW A;  4FBQ A;  4WWL A;  5IOH A;  1G5B A;  1AUI A;  3IVE A;  3JYF A;  4ORB A;  3THN A;  1Z2W A;  1OID A;  2IE3 C;  4KBP A;  2QFR A;  2Q8U A;  3C5W C;  3KBP A;  3GVE A;  1NNW A;  2HY1 A;  4UT3 B;  1W24 A;  2Z06 A;  3FGA C;  1UF3 A;  3QFO A;  4DT2 A;  1USH A;  3H61 A;  2IE4 C;  4ZX2 A;  1S3M A;  1T70 A;  5JPE A;  1V73 A;  3H66 A;  3QFN A;  4MOV A;  1XZW A;  4H1Y P;  3CK2 A;  1OI8 A;  2GJU A;  2HYP A;  4LAC C;  2DFJ A;  3H69 A;  3H60 A;  1WAO 1;  1QHW A;  2WDF A;  3P71 C;  4O24 A;  4ZVZ A;  3QFM A;  3E7B A;  4H2B A;  1WAR A;  1M63 A;  3K7W C;  5GTU A;  3LL8 A;  1S3N A;  5HPE A;  5INB A;  2WDC A;  4XPN A;  4MP0 A;  3EGH A;  1FJM A;  4FCX A;  3ZTV A;  3H67 A;  4H2F A;  5EQV A;  4TUI A;  4O5G A;  4V0X A;  1KBP A;  2O8A A;  3RL4 A;  5DNY A;  4I5L C;  3RL5 A;  3IB7 A;  4NZV A;  2ZBM A;  4V0V A;  4MOY A;  3H68 A;  2BCD A;  4J6O A;  1IT6 A;  2A22 A;  4KKZ A;  3N5U A;  4HD0 A;  5JPF A;  2AHD A;  1SU1 A;  3C9F A;  3H62 B;  4Q7F A;  4I5N C;  4H2I A;  2NYM C;  1II7 A;  1OIE A;  3PSO A;  4O4K A;  1XM7 A;  5C1V A;  2NPP C;  4JA7 A;  2BDX A;  2JOG A;  1Z2X A;  2XMO A;  4UT3 A;  1S70 A;  4F0Z A;  2O8G A;  3RQZ A;  2HYO A;  4DHL A; 
#chains in the Genus database with same CATH topology
 3AV0 A;  4IYP C;  4LU9 A;  4OR9 A;  4M0V A;  1JK7 A;  2YVT A;  2WDD A;  4G9J A;  2ZO9 B;  3QFK A;  1HP1 A;  1T71 A;  4TUG A;  3H64 A;  2QFP A;  4V0W A;  4O43 A;  1HO5 A;  2P6B A;  3K7V C;  4LTY A;  3ZU0 A;  1S3L A;  3DW8 C;  1U32 A;  3ICF A;  2R17 A;  4UT2 A;  4IL1 A;  1QFC A;  3DSD A;  3V4Y A;  5F3W A;  3DSC A;  2Z72 A;  4H2G A;  5JJT A;  3EGG A;  1HPU A;  3AUZ A;  5J28 A;  3IB8 A;  3IVD A;  3PSN A;  1UTE A;  2NYL C;  3TGH A;  2WDE A;  3D03 A;  2USH A;  1S95 A;  3E7A A;  3THO B;  4DSY A;  2IAE C;  1TCO A;  3HVQ A;  4B2O A;  4YKE A;  4H1S A;  4UWQ A;  2QJC A;  5B8I A;  2YEQ A;  3H63 A;  3T1I A;  2CV9 A;  2NXF A;  4FBK A;  2BQ8 X;  2KKN A;  3FLO A;  4ORC A;  3RL3 A;  2Z1A A;  3QG5 C;  4JA9 A;  1MF8 A;  4ORA A;  1S8E A;  4FBW A;  4FBQ A;  4WWL A;  5IOH A;  1G5B A;  1AUI A;  3IVE A;  3JYF A;  4ORB A;  3THN A;  1Z2W A;  1OID A;  2IE3 C;  4KBP A;  2QFR A;  2Q8U A;  3C5W C;  3KBP A;  3GVE A;  1NNW A;  2HY1 A;  4UT3 B;  1W24 A;  2Z06 A;  3FGA C;  1UF3 A;  3QFO A;  4DT2 A;  1USH A;  3H61 A;  2IE4 C;  4ZX2 A;  1S3M A;  1T70 A;  5JPE A;  1V73 A;  3H66 A;  3QFN A;  4MOV A;  1XZW A;  4H1Y P;  3CK2 A;  1OI8 A;  2GJU A;  2HYP A;  4LAC C;  2DFJ A;  3H69 A;  3E0J A;  3H60 A;  1WAO 1;  1QHW A;  2WDF A;  3P71 C;  4O24 A;  4ZVZ A;  3QFM A;  3E7B A;  4H2B A;  1WAR A;  1M63 A;  3K7W C;  5GTU A;  3LL8 A;  1S3N A;  5HPE A;  5INB A;  2WDC A;  4XPN A;  2ZOA A;  4MP0 A;  3EGH A;  1FJM A;  4FCX A;  3ZTV A;  3H67 A;  4H2F A;  5EQV A;  4TUI A;  4O5G A;  4V0X A;  1KBP A;  2O8A A;  3RL4 A;  5DNY A;  4I5L C;  3RL5 A;  3IB7 A;  4NZV A;  2ZBM A;  4V0V A;  4MOY A;  3H68 A;  2BCD A;  4J6O A;  1IT6 A;  2A22 A;  4KKZ A;  2DXL A;  3N5U A;  4HD0 A;  2DXN A;  5JPF A;  2AHD A;  1SU1 A;  3C9F A;  3H62 B;  4Q7F A;  4I5N C;  4H2I A;  2NYM C;  1II7 A;  1OIE A;  3PSO A;  4O4K A;  1XM7 A;  5C1V A;  2NPP C;  4JA7 A;  2BDX A;  2JOG A;  1Z2X A;  2XMO A;  4UT3 A;  1S70 A;  4F0Z A;  2O8G A;  3RQZ A;  2HYO A;  4DHL A; 
#chains in the Genus database with same CATH homology
 3AV0 A;  4IYP C;  4LU9 A;  4OR9 A;  4M0V A;  1JK7 A;  2YVT A;  2WDD A;  4G9J A;  2ZO9 B;  3QFK A;  1HP1 A;  1T71 A;  4TUG A;  3H64 A;  2QFP A;  4V0W A;  4O43 A;  1HO5 A;  2P6B A;  3K7V C;  4LTY A;  3ZU0 A;  1S3L A;  3DW8 C;  1U32 A;  3ICF A;  2R17 A;  4UT2 A;  4IL1 A;  1QFC A;  3DSD A;  3V4Y A;  5F3W A;  3DSC A;  2Z72 A;  4H2G A;  5JJT A;  3EGG A;  1HPU A;  3AUZ A;  5J28 A;  3IB8 A;  3IVD A;  3PSN A;  1UTE A;  2NYL C;  3TGH A;  2WDE A;  3D03 A;  2USH A;  1S95 A;  3E7A A;  3THO B;  4DSY A;  2IAE C;  1TCO A;  3HVQ A;  4B2O A;  4YKE A;  4H1S A;  4UWQ A;  2QJC A;  5B8I A;  2YEQ A;  3H63 A;  3T1I A;  2CV9 A;  2NXF A;  4FBK A;  2BQ8 X;  2KKN A;  3FLO A;  4ORC A;  3RL3 A;  2Z1A A;  3QG5 C;  4JA9 A;  1MF8 A;  4ORA A;  1S8E A;  4FBW A;  4FBQ A;  4WWL A;  5IOH A;  1G5B A;  1AUI A;  3IVE A;  3JYF A;  4ORB A;  3THN A;  1Z2W A;  1OID A;  2IE3 C;  4KBP A;  2QFR A;  2Q8U A;  3C5W C;  3KBP A;  3GVE A;  1NNW A;  2HY1 A;  4UT3 B;  1W24 A;  2Z06 A;  3FGA C;  1UF3 A;  3QFO A;  4DT2 A;  1USH A;  3H61 A;  2IE4 C;  4ZX2 A;  1S3M A;  1T70 A;  5JPE A;  1V73 A;  3H66 A;  3QFN A;  4MOV A;  1XZW A;  4H1Y P;  3CK2 A;  1OI8 A;  2GJU A;  2HYP A;  4LAC C;  2DFJ A;  3H69 A;  3E0J A;  3H60 A;  1WAO 1;  1QHW A;  2WDF A;  3P71 C;  4O24 A;  4ZVZ A;  3QFM A;  3E7B A;  4H2B A;  1WAR A;  1M63 A;  3K7W C;  5GTU A;  3LL8 A;  1S3N A;  5HPE A;  5INB A;  2WDC A;  4XPN A;  2ZOA A;  4MP0 A;  3EGH A;  1FJM A;  4FCX A;  3ZTV A;  3H67 A;  4H2F A;  5EQV A;  4TUI A;  4O5G A;  4V0X A;  1KBP A;  2O8A A;  3RL4 A;  5DNY A;  4I5L C;  3RL5 A;  3IB7 A;  4NZV A;  2ZBM A;  4V0V A;  4MOY A;  3H68 A;  2BCD A;  4J6O A;  1IT6 A;  2A22 A;  4KKZ A;  2DXL A;  3N5U A;  4HD0 A;  2DXN A;  5JPF A;  2AHD A;  1SU1 A;  3C9F A;  3H62 B;  4Q7F A;  4I5N C;  4H2I A;  2NYM C;  1II7 A;  1OIE A;  3PSO A;  4O4K A;  1XM7 A;  5C1V A;  2NPP C;  4JA7 A;  2BDX A;  2JOG A;  1Z2X A;  2XMO A;  4UT3 A;  1S70 A;  4F0Z A;  2O8G A;  3RQZ A;  2HYO A;  4DHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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