1TCOA

Ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus)
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
352
structure length
352
Chain Sequence
VPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNIC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
pubmed doi rcsb
molecule keywords SERINE/THREONINE PHOSPHATASE B2
molecule tags Complex (hydrolase/isomerase)
source organism Bos taurus
total genus 126
structure length 352
sequence length 352
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 1996-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1tcoA00
5C1VA 4V0XA 1HP1A 4V0VA 1M63A 2NYMC 4H2FA 3ZU0A 4Q7FA 3V4YA 3PSOA 4TUGA 5F3WA 2BDXA 1XM7A 2Q8UA 1HO5A 3DW8C 1S3MA 4O43A 4I5NC 4LACC 2HYPA 3RL3A 3QG5C 1WARA 4FCXA 4MP0A 4KKZA 1IT6A 2O8GA 1UTEA 4IL1A 4JA9A 2ZBMA 1NNWA 4YKEA 4O5GA 2WDEA 4LU9A 3ICFA 1AUIA 3P71C 1FJMA 3H66A 3N5UA 2BQ8X 3QFNA 1OIEA 3CK2A 1SU1A 1KBPA 2NPPC 1Z2WA 2DFJA 1S3NA 3K7WC 4H2BA 4J6OA 5INBA 1QHWA 2BCDA 1II7A 3H67A 4FBQA 3C5WC 1S70A 2IE3C 3H61A 4M0VA 4ZVZA 2IE4C 4DHLA 3EGGA 3H60A 1WAO1 4DSYA 4KBPA 3E7AA 1U32A 2GJUA 1QFCA 3AV0A 4B2OA 2JOGA 2WDDA 4H1YP 4ORAA 3KBPA 1S3LA 1OIDA 1USHA 4FBWA 4O4KA 3THOB 3EGHA 4H1SA 2XMOA 1UF3A 4MOVA 5EQVA 1V73A 4TUIA 2CV9A 2A22A 1JK7A 5JPFA 3IVEA 4ZX2A 1G5BA 5J28A 1S95A 3C9FA 2NXFA 3RL4A 4F0ZA 2QFPA 2AHDA 4IYPC 2R17A 5B8IA 3DSDA 4V0WA 4UT3A 2WDCA 3K7VC 4G9JA 1T71A 3TGHA 1Z2XA 4ORCA 3HVQA 4ORBA 3H69A 4UT3B 1MF8A 4JA7A 4DT2A 2P6BA 4UT2A 1W24A 3THNA 1XZWA 3H68A 4FBKA 1T70A 4O24A 3H64A 3LL8A 2YVTA 1HPUA 3T1IA 4UWQA 4WWLA 2NYLC 1S8EA 2Z06A 3IVDA 3H63A 3ZTVA 3IB7A 4H2IA 5HPEA 3JYFA 3H62B 3PSNA 2Z72A 2QFRA 5JJTA 5GTUA 2O8AA 3QFKA 3QFOA 2QJCA 4MOYA 1TCOA 4XPNA 2IAEC 4NZVA 3AUZA 3IB8A 2HY1A 4H2GA 5DNYA 3FGAC 3QFMA 4HD0A 3E7BA 5IOHA 3RL5A 3GVEA 2KKNA 4I5LC 4OR9A 2Z1AA 3DSCA 5JPEA 4LTYA 1OI8A 2HYOA 3RQZA 2USHA 2WDFA
chains in the Genus database with same CATH superfamily
5C1VA 4V0XA 1HP1A 4V0VA 1M63A 2NYMC 4H2FA 3ZU0A 4Q7FA 3V4YA 3PSOA 4TUGA 5F3WA 2BDXA 1XM7A 2Q8UA 1HO5A 3DW8C 1S3MA 4O43A 4I5NC 4LACC 2HYPA 3RL3A 3QG5C 1WARA 4FCXA 4MP0A 4KKZA 1IT6A 2O8GA 2YEQA 1UTEA 4IL1A 4JA9A 2ZBMA 1NNWA 4YKEA 4O5GA 2WDEA 4LU9A 3ICFA 1AUIA 3P71C 1FJMA 3H66A 3N5UA 2BQ8X 3QFNA 1OIEA 2ZOAA 3CK2A 1SU1A 1KBPA 2NPPC 1Z2WA 2DFJA 1S3NA 3K7WC 4H2BA 4J6OA 5INBA 1QHWA 2BCDA 3E0JA 1II7A 3H67A 4FBQA 3C5WC 1S70A 2IE3C 3H61A 4M0VA 4ZVZA 2IE4C 4DHLA 3EGGA 3H60A 1WAO1 2DXLA 4KBPA 4DSYA 3E7AA 1U32A 2GJUA 1QFCA 3AV0A 4B2OA 2JOGA 2WDDA 4H1YP 4ORAA 3KBPA 1S3LA 1OIDA 1USHA 4FBWA 4O4KA 3THOB 3EGHA 4H1SA 2XMOA 1UF3A 4MOVA 5EQVA 1V73A 4TUIA 2CV9A 2A22A 1JK7A 5JPFA 3IVEA 4ZX2A 1G5BA 3D03A 1S95A 3C9FA 2NXFA 3RL4A 5J28A 4F0ZA 2QFPA 2AHDA 4IYPC 2R17A 5B8IA 3DSDA 4V0WA 4UT3A 2WDCA 3K7VC 4G9JA 1T71A 3TGHA 1Z2XA 4ORCA 3HVQA 4ORBA 3H69A 4UT3B 1MF8A 4JA7A 4DT2A 2P6BA 4UT2A 1W24A 3THNA 1XZWA 3H68A 4FBKA 1T70A 4O24A 3H64A 3LL8A 2YVTA 1HPUA 3T1IA 4UWQA 4WWLA 2NYLC 1S8EA 2Z06A 3IVDA 3H63A 3ZTVA 3IB7A 4H2IA 5HPEA 3JYFA 3H62B 3PSNA 2Z72A 2QFRA 5JJTA 5GTUA 2DXNA 2O8AA 3QFKA 2ZO9B 3QFOA 2QJCA 4MOYA 1TCOA 4XPNA 2IAEC 4NZVA 3FLOA 3AUZA 3IB8A 2HY1A 4H2GA 5DNYA 3FGAC 3QFMA 4HD0A 3E7BA 5IOHA 3RL5A 3GVEA 2KKNA 4I5LC 4OR9A 2Z1AA 3DSCA 5JPEA 4LTYA 1OI8A 2HYOA 3RQZA 2USHA 2WDFA
chains in the Genus database with same CATH topology
5C1VA 4V0XA 1HP1A 4V0VA 1M63A 2NYMC 4H2FA 3ZU0A 4Q7FA 3V4YA 3PSOA 4TUGA 5F3WA 2BDXA 1XM7A 2Q8UA 1HO5A 3DW8C 1S3MA 4O43A 4I5NC 4LACC 2HYPA 3RL3A 3QG5C 1WARA 4FCXA 4MP0A 4KKZA 1IT6A 2O8GA 2YEQA 1UTEA 4IL1A 4JA9A 2ZBMA 1NNWA 4YKEA 4O5GA 2WDEA 4LU9A 3ICFA 1AUIA 3P71C 1FJMA 3H66A 3N5UA 2BQ8X 3QFNA 1OIEA 2ZOAA 3CK2A 1SU1A 1KBPA 2NPPC 1Z2WA 2DFJA 1S3NA 3K7WC 4H2BA 4J6OA 5INBA 1QHWA 2BCDA 3E0JA 1II7A 3H67A 4FBQA 3C5WC 1S70A 2IE3C 3H61A 4M0VA 4ZVZA 2IE4C 4DHLA 3EGGA 3H60A 1WAO1 2DXLA 4KBPA 4DSYA 3E7AA 1U32A 2GJUA 1QFCA 3AV0A 4B2OA 2JOGA 2WDDA 4H1YP 4ORAA 3KBPA 1S3LA 1OIDA 1USHA 4FBWA 4O4KA 3THOB 3EGHA 4H1SA 2XMOA 1UF3A 4MOVA 5EQVA 1V73A 4TUIA 2CV9A 2A22A 1JK7A 5JPFA 3IVEA 4ZX2A 1G5BA 3D03A 1S95A 3C9FA 2NXFA 3RL4A 5J28A 4F0ZA 2QFPA 2AHDA 4IYPC 2R17A 5B8IA 3DSDA 4V0WA 4UT3A 2WDCA 3K7VC 4G9JA 1T71A 3TGHA 1Z2XA 4ORCA 3HVQA 4ORBA 3H69A 4UT3B 1MF8A 4JA7A 4DT2A 2P6BA 4UT2A 1W24A 3THNA 1XZWA 3H68A 4FBKA 1T70A 4O24A 3H64A 3LL8A 2YVTA 1HPUA 3T1IA 4UWQA 4WWLA 2NYLC 1S8EA 2Z06A 3IVDA 3H63A 3ZTVA 3IB7A 4H2IA 5HPEA 3JYFA 3H62B 3PSNA 2Z72A 2QFRA 5JJTA 5GTUA 2DXNA 2O8AA 3QFKA 2ZO9B 3QFOA 2QJCA 4MOYA 1TCOA 4XPNA 2IAEC 4NZVA 3FLOA 3AUZA 3IB8A 2HY1A 4H2GA 5DNYA 3FGAC 3QFMA 4HD0A 3E7BA 5IOHA 3RL5A 3GVEA 2KKNA 4I5LC 4OR9A 2Z1AA 3DSCA 5JPEA 4LTYA 1OI8A 2HYOA 3RQZA 2USHA 2WDFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C1V A;  4V0X A;  1HP1 A;  4V0V A;  1M63 A;  2NYM C;  4H2F A;  3ZU0 A;  4Q7F A;  3V4Y A;  3PSO A;  4TUG A;  5F3W A;  2BDX A;  1XM7 A;  2Q8U A;  1HO5 A;  3DW8 C;  1S3M A;  4O43 A;  4I5N C;  4LAC C;  2HYP A;  3RL3 A;  3QG5 C;  1WAR A;  4FCX A;  4MP0 A;  4KKZ A;  1IT6 A;  2O8G A;  1UTE A;  4IL1 A;  4JA9 A;  2ZBM A;  1NNW A;  4YKE A;  4O5G A;  2WDE A;  4LU9 A;  3ICF A;  1AUI A;  3P71 C;  1FJM A;  3H66 A;  3N5U A;  2BQ8 X;  3QFN A;  1OIE A;  3CK2 A;  1SU1 A;  1KBP A;  2NPP C;  1Z2W A;  2DFJ A;  1S3N A;  3K7W C;  4H2B A;  4J6O A;  5INB A;  1QHW A;  2BCD A;  1II7 A;  3H67 A;  4FBQ A;  3C5W C;  1S70 A;  2IE3 C;  3H61 A;  4M0V A;  4ZVZ A;  2IE4 C;  4DHL A;  3EGG A;  3H60 A;  1WAO 1;  4DSY A;  4KBP A;  3E7A A;  1U32 A;  2GJU A;  1QFC A;  3AV0 A;  4B2O A;  2JOG A;  2WDD A;  4H1Y P;  4ORA A;  3KBP A;  1S3L A;  1OID A;  1USH A;  4FBW A;  4O4K A;  3THO B;  3EGH A;  4H1S A;  2XMO A;  1UF3 A;  4MOV A;  5EQV A;  1V73 A;  4TUI A;  2CV9 A;  2A22 A;  1JK7 A;  5JPF A;  3IVE A;  4ZX2 A;  1G5B A;  5J28 A;  1S95 A;  3C9F A;  2NXF A;  3RL4 A;  4F0Z A;  2QFP A;  2AHD A;  4IYP C;  2R17 A;  5B8I A;  3DSD A;  4V0W A;  4UT3 A;  2WDC A;  3K7V C;  4G9J A;  1T71 A;  3TGH A;  1Z2X A;  4ORC A;  3HVQ A;  4ORB A;  3H69 A;  4UT3 B;  1MF8 A;  4JA7 A;  4DT2 A;  2P6B A;  4UT2 A;  1W24 A;  3THN A;  1XZW A;  3H68 A;  4FBK A;  1T70 A;  4O24 A;  3H64 A;  3LL8 A;  2YVT A;  1HPU A;  3T1I A;  4UWQ A;  4WWL A;  2NYL C;  1S8E A;  2Z06 A;  3IVD A;  3H63 A;  3ZTV A;  3IB7 A;  4H2I A;  5HPE A;  3JYF A;  3H62 B;  3PSN A;  2Z72 A;  2QFR A;  5JJT A;  5GTU A;  2O8A A;  3QFK A;  3QFO A;  2QJC A;  4MOY A;  1TCO A;  4XPN A;  2IAE C;  4NZV A;  3AUZ A;  3IB8 A;  2HY1 A;  4H2G A;  5DNY A;  3FGA C;  3QFM A;  4HD0 A;  3E7B A;  5IOH A;  3RL5 A;  3GVE A;  2KKN A;  4I5L C;  4OR9 A;  2Z1A A;  3DSC A;  5JPE A;  4LTY A;  1OI8 A;  2HYO A;  3RQZ A;  2USH A;  2WDF A; 
#chains in the Genus database with same CATH topology
 5C1V A;  4V0X A;  1HP1 A;  4V0V A;  1M63 A;  2NYM C;  4H2F A;  3ZU0 A;  4Q7F A;  3V4Y A;  3PSO A;  4TUG A;  5F3W A;  2BDX A;  1XM7 A;  2Q8U A;  1HO5 A;  3DW8 C;  1S3M A;  4O43 A;  4I5N C;  4LAC C;  2HYP A;  3RL3 A;  3QG5 C;  1WAR A;  4FCX A;  4MP0 A;  4KKZ A;  1IT6 A;  2O8G A;  2YEQ A;  1UTE A;  4IL1 A;  4JA9 A;  2ZBM A;  1NNW A;  4YKE A;  4O5G A;  2WDE A;  4LU9 A;  3ICF A;  1AUI A;  3P71 C;  1FJM A;  3H66 A;  3N5U A;  2BQ8 X;  3QFN A;  1OIE A;  2ZOA A;  3CK2 A;  1SU1 A;  1KBP A;  2NPP C;  1Z2W A;  2DFJ A;  1S3N A;  3K7W C;  4H2B A;  4J6O A;  5INB A;  1QHW A;  2BCD A;  3E0J A;  1II7 A;  3H67 A;  4FBQ A;  3C5W C;  1S70 A;  2IE3 C;  3H61 A;  4M0V A;  4ZVZ A;  2IE4 C;  4DHL A;  3EGG A;  3H60 A;  1WAO 1;  2DXL A;  4KBP A;  4DSY A;  3E7A A;  1U32 A;  2GJU A;  1QFC A;  3AV0 A;  4B2O A;  2JOG A;  2WDD A;  4H1Y P;  4ORA A;  3KBP A;  1S3L A;  1OID A;  1USH A;  4FBW A;  4O4K A;  3THO B;  3EGH A;  4H1S A;  2XMO A;  1UF3 A;  4MOV A;  5EQV A;  1V73 A;  4TUI A;  2CV9 A;  2A22 A;  1JK7 A;  5JPF A;  3IVE A;  4ZX2 A;  1G5B A;  3D03 A;  1S95 A;  3C9F A;  2NXF A;  3RL4 A;  5J28 A;  4F0Z A;  2QFP A;  2AHD A;  4IYP C;  2R17 A;  5B8I A;  3DSD A;  4V0W A;  4UT3 A;  2WDC A;  3K7V C;  4G9J A;  1T71 A;  3TGH A;  1Z2X A;  4ORC A;  3HVQ A;  4ORB A;  3H69 A;  4UT3 B;  1MF8 A;  4JA7 A;  4DT2 A;  2P6B A;  4UT2 A;  1W24 A;  3THN A;  1XZW A;  3H68 A;  4FBK A;  1T70 A;  4O24 A;  3H64 A;  3LL8 A;  2YVT A;  1HPU A;  3T1I A;  4UWQ A;  4WWL A;  2NYL C;  1S8E A;  2Z06 A;  3IVD A;  3H63 A;  3ZTV A;  3IB7 A;  4H2I A;  5HPE A;  3JYF A;  3H62 B;  3PSN A;  2Z72 A;  2QFR A;  5JJT A;  5GTU A;  2DXN A;  2O8A A;  3QFK A;  2ZO9 B;  3QFO A;  2QJC A;  4MOY A;  1TCO A;  4XPN A;  2IAE C;  4NZV A;  3FLO A;  3AUZ A;  3IB8 A;  2HY1 A;  4H2G A;  5DNY A;  3FGA C;  3QFM A;  4HD0 A;  3E7B A;  5IOH A;  3RL5 A;  3GVE A;  2KKN A;  4I5L C;  4OR9 A;  2Z1A A;  3DSC A;  5JPE A;  4LTY A;  1OI8 A;  2HYO A;  3RQZ A;  2USH A;  2WDF A; 
#chains in the Genus database with same CATH homology
 5C1V A;  4V0X A;  1HP1 A;  4V0V A;  1M63 A;  2NYM C;  4H2F A;  3ZU0 A;  4Q7F A;  3V4Y A;  3PSO A;  4TUG A;  5F3W A;  2BDX A;  1XM7 A;  2Q8U A;  1HO5 A;  3DW8 C;  1S3M A;  4O43 A;  4I5N C;  4LAC C;  2HYP A;  3RL3 A;  3QG5 C;  1WAR A;  4FCX A;  4MP0 A;  4KKZ A;  1IT6 A;  2O8G A;  2YEQ A;  1UTE A;  4IL1 A;  4JA9 A;  2ZBM A;  1NNW A;  4YKE A;  4O5G A;  2WDE A;  4LU9 A;  3ICF A;  1AUI A;  3P71 C;  1FJM A;  3H66 A;  3N5U A;  2BQ8 X;  3QFN A;  1OIE A;  2ZOA A;  3CK2 A;  1SU1 A;  1KBP A;  2NPP C;  1Z2W A;  2DFJ A;  1S3N A;  3K7W C;  4H2B A;  4J6O A;  5INB A;  1QHW A;  2BCD A;  3E0J A;  1II7 A;  3H67 A;  4FBQ A;  3C5W C;  1S70 A;  2IE3 C;  3H61 A;  4M0V A;  4ZVZ A;  2IE4 C;  4DHL A;  3EGG A;  3H60 A;  1WAO 1;  2DXL A;  4KBP A;  4DSY A;  3E7A A;  1U32 A;  2GJU A;  1QFC A;  3AV0 A;  4B2O A;  2JOG A;  2WDD A;  4H1Y P;  4ORA A;  3KBP A;  1S3L A;  1OID A;  1USH A;  4FBW A;  4O4K A;  3THO B;  3EGH A;  4H1S A;  2XMO A;  1UF3 A;  4MOV A;  5EQV A;  1V73 A;  4TUI A;  2CV9 A;  2A22 A;  1JK7 A;  5JPF A;  3IVE A;  4ZX2 A;  1G5B A;  3D03 A;  1S95 A;  3C9F A;  2NXF A;  3RL4 A;  5J28 A;  4F0Z A;  2QFP A;  2AHD A;  4IYP C;  2R17 A;  5B8I A;  3DSD A;  4V0W A;  4UT3 A;  2WDC A;  3K7V C;  4G9J A;  1T71 A;  3TGH A;  1Z2X A;  4ORC A;  3HVQ A;  4ORB A;  3H69 A;  4UT3 B;  1MF8 A;  4JA7 A;  4DT2 A;  2P6B A;  4UT2 A;  1W24 A;  3THN A;  1XZW A;  3H68 A;  4FBK A;  1T70 A;  4O24 A;  3H64 A;  3LL8 A;  2YVT A;  1HPU A;  3T1I A;  4UWQ A;  4WWL A;  2NYL C;  1S8E A;  2Z06 A;  3IVD A;  3H63 A;  3ZTV A;  3IB7 A;  4H2I A;  5HPE A;  3JYF A;  3H62 B;  3PSN A;  2Z72 A;  2QFR A;  5JJT A;  5GTU A;  2DXN A;  2O8A A;  3QFK A;  2ZO9 B;  3QFO A;  2QJC A;  4MOY A;  1TCO A;  4XPN A;  2IAE C;  4NZV A;  3FLO A;  3AUZ A;  3IB8 A;  2HY1 A;  4H2G A;  5DNY A;  3FGA C;  3QFM A;  4HD0 A;  3E7B A;  5IOH A;  3RL5 A;  3GVE A;  2KKN A;  4I5L C;  4OR9 A;  2Z1A A;  3DSC A;  5JPE A;  4LTY A;  1OI8 A;  2HYO A;  3RQZ A;  2USH A;  2WDF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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