1IT6A

Crystal structure of the complex between calyculin a and the catalytic subunit of protein phosphatase 1
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
293
structure length
293
Chain Sequence
LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords SERINE/THREONINE PROTEIN PHOSPHATASE 1 GAMMA (PP1-GAMMA) CAT
total genus 109
structure length 293
sequence length 293
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2002-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1it6A00
2R17A 4V0XA 5HPEA 1WAO1 4I5LC 2IAEC 1T70A 4ORBA 4G9JA 2USHA 2IE3C 2NYLC 2HYOA 4WWLA 4H2GA 1S3LA 3AUZA 1NNWA 4FBKA 3DW8C 3K7VC 2Z72A 2JOGA 4JA9A 1S70A 4TUGA 3EGHA 2WDEA 3THOB 4LTYA 3ZU0A 1USHA 4O4KA 4MOVA 4H1SA 4O5GA 1Z2WA 5C1VA 3H60A 1II7A 3IB7A 2A22A 3H62B 1OIDA 4UT2A 1V73A 4B2OA 4DHLA 4NZVA 4LACC 3RL4A 2WDFA 1IT6A 1HO5A 3H68A 4FCXA 4DSYA 4LU9A 5JPFA 2BCDA 4UWQA 4I5NC 3N5UA 5GTUA 2P6BA 3IVEA 4ORCA 3PSOA 5EQVA 3H61A 1XZWA 2QFPA 2WDDA 5INBA 4KBPA 4HD0A 3DSDA 1U32A 2DFJA 1S3NA 2XMOA 3E7BA 3K7WC 3RL3A 4M0VA 1MF8A 1UTEA 4O24A 1OIEA 3IB8A 4IL1A 3ICFA 3TGHA 3H69A 3QFMA 1Z2XA 2IE4C 1QHWA 2NPPC 3H63A 1UF3A 4ZX2A 1SU1A 3C9FA 3JYFA 1S95A 4UT3A 2AHDA 3PSNA 4Q7FA 4JA7A 1JK7A 3CK2A 3E7AA 1S3MA 3GVEA 2O8AA 2QFRA 2Z1AA 3LL8A 2HY1A 2WDCA 3V4YA 3THNA 4J6OA 3RL5A 4FBQA 4KKZA 3FGAC 4V0WA 1G5BA 2HYPA 1S8EA 3H67A 3H64A 5JJTA 2Z06A 3P71C 5IOHA 4MP0A 1QFCA 4DT2A 3AV0A 2BDXA 2Q8UA 4ORAA 3DSCA 4F0ZA 4V0VA 4UT3B 3QG5C 4XPNA 4YKEA 2ZBMA 3C5WC 5J28A 2GJUA 2QJCA 4H1YP 3QFOA 1M63A 1TCOA 2BQ8X 1XM7A 3QFKA 4H2FA 2NXFA 3H66A 1HPUA 4MOYA 4IYPC 5JPEA 1AUIA 3EGGA 1W24A 2CV9A 5DNYA 4H2IA 4OR9A 1T71A 3KBPA 3RQZA 4TUIA 5B8IA 4FBWA 2O8GA 1HP1A 5F3WA 2KKNA 1OI8A 3HVQA 1WARA 1KBPA 3T1IA 2YVTA 3ZTVA 3IVDA 4ZVZA 3QFNA 2NYMC 4O43A 4H2BA 1FJMA
chains in the Genus database with same CATH superfamily
2R17A 4V0XA 5HPEA 1WAO1 4I5LC 2IAEC 1T70A 4ORBA 4G9JA 2USHA 2IE3C 2NYLC 2HYOA 4WWLA 4H2GA 1S3LA 2DXLA 3AUZA 1NNWA 4FBKA 3DW8C 3K7VC 2Z72A 2JOGA 4JA9A 1S70A 4TUGA 3EGHA 2WDEA 3THOB 4LTYA 3ZU0A 1USHA 4O4KA 4MOVA 4H1SA 4O5GA 1Z2WA 5C1VA 3H60A 1II7A 3IB7A 2A22A 3H62B 1OIDA 4UT2A 1V73A 4B2OA 4DHLA 4NZVA 4LACC 3RL4A 2WDFA 1IT6A 1HO5A 3H68A 4FCXA 4DSYA 4LU9A 5JPFA 2BCDA 4UWQA 4I5NC 3N5UA 5GTUA 2P6BA 3IVEA 4ORCA 3PSOA 5EQVA 3H61A 1XZWA 2QFPA 2WDDA 5INBA 4KBPA 4HD0A 3DSDA 1U32A 2DFJA 1S3NA 2XMOA 3E7BA 3K7WC 3RL3A 4M0VA 1MF8A 2YEQA 1UTEA 4O24A 1OIEA 3IB8A 4IL1A 3ICFA 3TGHA 3H69A 3QFMA 1Z2XA 2ZO9B 3D03A 2IE4C 1QHWA 2NPPC 3H63A 1UF3A 4ZX2A 1SU1A 3C9FA 3JYFA 1S95A 4UT3A 2AHDA 3PSNA 4Q7FA 4JA7A 1JK7A 3CK2A 3E7AA 1S3MA 3GVEA 2O8AA 2QFRA 2Z1AA 3LL8A 2HY1A 2WDCA 3V4YA 3THNA 4J6OA 3RL5A 4FBQA 4KKZA 3FGAC 4V0WA 1G5BA 2HYPA 1S8EA 3H67A 3H64A 5JJTA 2Z06A 3P71C 5IOHA 4MP0A 1QFCA 4DT2A 3AV0A 2BDXA 2Q8UA 4ORAA 3DSCA 4F0ZA 4V0VA 4UT3B 3QG5C 4XPNA 4YKEA 2ZBMA 3C5WC 5J28A 2GJUA 2QJCA 4H1YP 3QFOA 1M63A 1TCOA 2BQ8X 1XM7A 3QFKA 4H2FA 3E0JA 2NXFA 3H66A 1HPUA 3FLOA 4MOYA 4IYPC 5JPEA 1AUIA 3EGGA 1W24A 2CV9A 5DNYA 4H2IA 4OR9A 1T71A 3KBPA 2ZOAA 3RQZA 4TUIA 5B8IA 4FBWA 2O8GA 1HP1A 2DXNA 5F3WA 2KKNA 1OI8A 3HVQA 1WARA 1KBPA 3T1IA 2YVTA 3ZTVA 3IVDA 4ZVZA 3QFNA 2NYMC 4O43A 4H2BA 1FJMA
chains in the Genus database with same CATH topology
2R17A 4V0XA 5HPEA 1WAO1 4I5LC 2IAEC 1T70A 4ORBA 4G9JA 2USHA 2IE3C 2NYLC 2HYOA 4WWLA 4H2GA 1S3LA 2DXLA 3AUZA 1NNWA 4FBKA 3DW8C 3K7VC 2Z72A 2JOGA 4JA9A 1S70A 4TUGA 3EGHA 2WDEA 3THOB 4LTYA 3ZU0A 1USHA 4O4KA 4MOVA 4H1SA 4O5GA 1Z2WA 5C1VA 3H60A 1II7A 3IB7A 2A22A 3H62B 1OIDA 4UT2A 1V73A 4B2OA 4DHLA 4NZVA 4LACC 3RL4A 2WDFA 1IT6A 1HO5A 3H68A 4FCXA 4DSYA 4LU9A 5JPFA 2BCDA 4UWQA 4I5NC 3N5UA 5GTUA 2P6BA 3IVEA 4ORCA 3PSOA 5EQVA 3H61A 1XZWA 2QFPA 2WDDA 5INBA 4KBPA 4HD0A 3DSDA 1U32A 2DFJA 1S3NA 2XMOA 3E7BA 3K7WC 3RL3A 4M0VA 1MF8A 2YEQA 1UTEA 4O24A 1OIEA 3IB8A 4IL1A 3ICFA 3TGHA 3H69A 3QFMA 1Z2XA 2ZO9B 3D03A 2IE4C 1QHWA 2NPPC 3H63A 1UF3A 4ZX2A 1SU1A 3C9FA 3JYFA 1S95A 4UT3A 2AHDA 3PSNA 4Q7FA 4JA7A 1JK7A 3CK2A 3E7AA 1S3MA 3GVEA 2O8AA 2QFRA 2Z1AA 3LL8A 2HY1A 2WDCA 3V4YA 3THNA 4J6OA 3RL5A 4FBQA 4KKZA 3FGAC 4V0WA 1G5BA 2HYPA 1S8EA 3H67A 3H64A 5JJTA 2Z06A 3P71C 5IOHA 4MP0A 1QFCA 4DT2A 3AV0A 2BDXA 2Q8UA 4ORAA 3DSCA 4F0ZA 4V0VA 4UT3B 3QG5C 4XPNA 4YKEA 2ZBMA 3C5WC 5J28A 2GJUA 2QJCA 4H1YP 3QFOA 1M63A 1TCOA 2BQ8X 1XM7A 3QFKA 4H2FA 3E0JA 2NXFA 3H66A 1HPUA 3FLOA 4MOYA 4IYPC 5JPEA 1AUIA 3EGGA 1W24A 2CV9A 5DNYA 4H2IA 4OR9A 1T71A 3KBPA 2ZOAA 3RQZA 4TUIA 5B8IA 4FBWA 2O8GA 1HP1A 2DXNA 5F3WA 2KKNA 1OI8A 3HVQA 1WARA 1KBPA 3T1IA 2YVTA 3ZTVA 3IVDA 4ZVZA 3QFNA 2NYMC 4O43A 4H2BA 1FJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R17 A;  4V0X A;  5HPE A;  1WAO 1;  4I5L C;  2IAE C;  1T70 A;  4ORB A;  4G9J A;  2USH A;  2IE3 C;  2NYL C;  2HYO A;  4WWL A;  4H2G A;  1S3L A;  3AUZ A;  1NNW A;  4FBK A;  3DW8 C;  3K7V C;  2Z72 A;  2JOG A;  4JA9 A;  1S70 A;  4TUG A;  3EGH A;  2WDE A;  3THO B;  4LTY A;  3ZU0 A;  1USH A;  4O4K A;  4MOV A;  4H1S A;  4O5G A;  1Z2W A;  5C1V A;  3H60 A;  1II7 A;  3IB7 A;  2A22 A;  3H62 B;  1OID A;  4UT2 A;  1V73 A;  4B2O A;  4DHL A;  4NZV A;  4LAC C;  3RL4 A;  2WDF A;  1IT6 A;  1HO5 A;  3H68 A;  4FCX A;  4DSY A;  4LU9 A;  5JPF A;  2BCD A;  4UWQ A;  4I5N C;  3N5U A;  5GTU A;  2P6B A;  3IVE A;  4ORC A;  3PSO A;  5EQV A;  3H61 A;  1XZW A;  2QFP A;  2WDD A;  5INB A;  4KBP A;  4HD0 A;  3DSD A;  1U32 A;  2DFJ A;  1S3N A;  2XMO A;  3E7B A;  3K7W C;  3RL3 A;  4M0V A;  1MF8 A;  1UTE A;  4O24 A;  1OIE A;  3IB8 A;  4IL1 A;  3ICF A;  3TGH A;  3H69 A;  3QFM A;  1Z2X A;  2IE4 C;  1QHW A;  2NPP C;  3H63 A;  1UF3 A;  4ZX2 A;  1SU1 A;  3C9F A;  3JYF A;  1S95 A;  4UT3 A;  2AHD A;  3PSN A;  4Q7F A;  4JA7 A;  1JK7 A;  3CK2 A;  3E7A A;  1S3M A;  3GVE A;  2O8A A;  2QFR A;  2Z1A A;  3LL8 A;  2HY1 A;  2WDC A;  3V4Y A;  3THN A;  4J6O A;  3RL5 A;  4FBQ A;  4KKZ A;  3FGA C;  4V0W A;  1G5B A;  2HYP A;  1S8E A;  3H67 A;  3H64 A;  5JJT A;  2Z06 A;  3P71 C;  5IOH A;  4MP0 A;  1QFC A;  4DT2 A;  3AV0 A;  2BDX A;  2Q8U A;  4ORA A;  3DSC A;  4F0Z A;  4V0V A;  4UT3 B;  3QG5 C;  4XPN A;  4YKE A;  2ZBM A;  3C5W C;  5J28 A;  2GJU A;  2QJC A;  4H1Y P;  3QFO A;  1M63 A;  1TCO A;  2BQ8 X;  1XM7 A;  3QFK A;  4H2F A;  2NXF A;  3H66 A;  1HPU A;  4MOY A;  4IYP C;  5JPE A;  1AUI A;  3EGG A;  1W24 A;  2CV9 A;  5DNY A;  4H2I A;  4OR9 A;  1T71 A;  3KBP A;  3RQZ A;  4TUI A;  5B8I A;  4FBW A;  2O8G A;  1HP1 A;  5F3W A;  2KKN A;  1OI8 A;  3HVQ A;  1WAR A;  1KBP A;  3T1I A;  2YVT A;  3ZTV A;  3IVD A;  4ZVZ A;  3QFN A;  2NYM C;  4O43 A;  4H2B A;  1FJM A; 
#chains in the Genus database with same CATH topology
 2R17 A;  4V0X A;  5HPE A;  1WAO 1;  4I5L C;  2IAE C;  1T70 A;  4ORB A;  4G9J A;  2USH A;  2IE3 C;  2NYL C;  2HYO A;  4WWL A;  4H2G A;  1S3L A;  2DXL A;  3AUZ A;  1NNW A;  4FBK A;  3DW8 C;  3K7V C;  2Z72 A;  2JOG A;  4JA9 A;  1S70 A;  4TUG A;  3EGH A;  2WDE A;  3THO B;  4LTY A;  3ZU0 A;  1USH A;  4O4K A;  4MOV A;  4H1S A;  4O5G A;  1Z2W A;  5C1V A;  3H60 A;  1II7 A;  3IB7 A;  2A22 A;  3H62 B;  1OID A;  4UT2 A;  1V73 A;  4B2O A;  4DHL A;  4NZV A;  4LAC C;  3RL4 A;  2WDF A;  1IT6 A;  1HO5 A;  3H68 A;  4FCX A;  4DSY A;  4LU9 A;  5JPF A;  2BCD A;  4UWQ A;  4I5N C;  3N5U A;  5GTU A;  2P6B A;  3IVE A;  4ORC A;  3PSO A;  5EQV A;  3H61 A;  1XZW A;  2QFP A;  2WDD A;  5INB A;  4KBP A;  4HD0 A;  3DSD A;  1U32 A;  2DFJ A;  1S3N A;  2XMO A;  3E7B A;  3K7W C;  3RL3 A;  4M0V A;  1MF8 A;  2YEQ A;  1UTE A;  4O24 A;  1OIE A;  3IB8 A;  4IL1 A;  3ICF A;  3TGH A;  3H69 A;  3QFM A;  1Z2X A;  2ZO9 B;  3D03 A;  2IE4 C;  1QHW A;  2NPP C;  3H63 A;  1UF3 A;  4ZX2 A;  1SU1 A;  3C9F A;  3JYF A;  1S95 A;  4UT3 A;  2AHD A;  3PSN A;  4Q7F A;  4JA7 A;  1JK7 A;  3CK2 A;  3E7A A;  1S3M A;  3GVE A;  2O8A A;  2QFR A;  2Z1A A;  3LL8 A;  2HY1 A;  2WDC A;  3V4Y A;  3THN A;  4J6O A;  3RL5 A;  4FBQ A;  4KKZ A;  3FGA C;  4V0W A;  1G5B A;  2HYP A;  1S8E A;  3H67 A;  3H64 A;  5JJT A;  2Z06 A;  3P71 C;  5IOH A;  4MP0 A;  1QFC A;  4DT2 A;  3AV0 A;  2BDX A;  2Q8U A;  4ORA A;  3DSC A;  4F0Z A;  4V0V A;  4UT3 B;  3QG5 C;  4XPN A;  4YKE A;  2ZBM A;  3C5W C;  5J28 A;  2GJU A;  2QJC A;  4H1Y P;  3QFO A;  1M63 A;  1TCO A;  2BQ8 X;  1XM7 A;  3QFK A;  4H2F A;  3E0J A;  2NXF A;  3H66 A;  1HPU A;  3FLO A;  4MOY A;  4IYP C;  5JPE A;  1AUI A;  3EGG A;  1W24 A;  2CV9 A;  5DNY A;  4H2I A;  4OR9 A;  1T71 A;  3KBP A;  2ZOA A;  3RQZ A;  4TUI A;  5B8I A;  4FBW A;  2O8G A;  1HP1 A;  2DXN A;  5F3W A;  2KKN A;  1OI8 A;  3HVQ A;  1WAR A;  1KBP A;  3T1I A;  2YVT A;  3ZTV A;  3IVD A;  4ZVZ A;  3QFN A;  2NYM C;  4O43 A;  4H2B A;  1FJM A; 
#chains in the Genus database with same CATH homology
 2R17 A;  4V0X A;  5HPE A;  1WAO 1;  4I5L C;  2IAE C;  1T70 A;  4ORB A;  4G9J A;  2USH A;  2IE3 C;  2NYL C;  2HYO A;  4WWL A;  4H2G A;  1S3L A;  2DXL A;  3AUZ A;  1NNW A;  4FBK A;  3DW8 C;  3K7V C;  2Z72 A;  2JOG A;  4JA9 A;  1S70 A;  4TUG A;  3EGH A;  2WDE A;  3THO B;  4LTY A;  3ZU0 A;  1USH A;  4O4K A;  4MOV A;  4H1S A;  4O5G A;  1Z2W A;  5C1V A;  3H60 A;  1II7 A;  3IB7 A;  2A22 A;  3H62 B;  1OID A;  4UT2 A;  1V73 A;  4B2O A;  4DHL A;  4NZV A;  4LAC C;  3RL4 A;  2WDF A;  1IT6 A;  1HO5 A;  3H68 A;  4FCX A;  4DSY A;  4LU9 A;  5JPF A;  2BCD A;  4UWQ A;  4I5N C;  3N5U A;  5GTU A;  2P6B A;  3IVE A;  4ORC A;  3PSO A;  5EQV A;  3H61 A;  1XZW A;  2QFP A;  2WDD A;  5INB A;  4KBP A;  4HD0 A;  3DSD A;  1U32 A;  2DFJ A;  1S3N A;  2XMO A;  3E7B A;  3K7W C;  3RL3 A;  4M0V A;  1MF8 A;  2YEQ A;  1UTE A;  4O24 A;  1OIE A;  3IB8 A;  4IL1 A;  3ICF A;  3TGH A;  3H69 A;  3QFM A;  1Z2X A;  2ZO9 B;  3D03 A;  2IE4 C;  1QHW A;  2NPP C;  3H63 A;  1UF3 A;  4ZX2 A;  1SU1 A;  3C9F A;  3JYF A;  1S95 A;  4UT3 A;  2AHD A;  3PSN A;  4Q7F A;  4JA7 A;  1JK7 A;  3CK2 A;  3E7A A;  1S3M A;  3GVE A;  2O8A A;  2QFR A;  2Z1A A;  3LL8 A;  2HY1 A;  2WDC A;  3V4Y A;  3THN A;  4J6O A;  3RL5 A;  4FBQ A;  4KKZ A;  3FGA C;  4V0W A;  1G5B A;  2HYP A;  1S8E A;  3H67 A;  3H64 A;  5JJT A;  2Z06 A;  3P71 C;  5IOH A;  4MP0 A;  1QFC A;  4DT2 A;  3AV0 A;  2BDX A;  2Q8U A;  4ORA A;  3DSC A;  4F0Z A;  4V0V A;  4UT3 B;  3QG5 C;  4XPN A;  4YKE A;  2ZBM A;  3C5W C;  5J28 A;  2GJU A;  2QJC A;  4H1Y P;  3QFO A;  1M63 A;  1TCO A;  2BQ8 X;  1XM7 A;  3QFK A;  4H2F A;  3E0J A;  2NXF A;  3H66 A;  1HPU A;  3FLO A;  4MOY A;  4IYP C;  5JPE A;  1AUI A;  3EGG A;  1W24 A;  2CV9 A;  5DNY A;  4H2I A;  4OR9 A;  1T71 A;  3KBP A;  2ZOA A;  3RQZ A;  4TUI A;  5B8I A;  4FBW A;  2O8G A;  1HP1 A;  2DXN A;  5F3W A;  2KKN A;  1OI8 A;  3HVQ A;  1WAR A;  1KBP A;  3T1I A;  2YVT A;  3ZTV A;  3IVD A;  4ZVZ A;  3QFN A;  2NYM C;  4O43 A;  4H2B A;  1FJM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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