The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
104
|
sequence length |
372
|
structure length |
372
|
Chain Sequence |
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNIC
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
pubmed doi rcsb |
| molecule tags |
Hydrolase/isomerase/immunosuppressant
|
| source organism |
Homo sapiens
|
| molecule keywords |
SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, A
|
| total genus |
104
|
| structure length |
372
|
| sequence length |
372
|
| chains with identical sequence |
E
|
| ec nomenclature |
ec
3.1.3.16: Protein-serine/threonine phosphatase. |
| pdb deposition date | 2002-07-12 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00149 | Metallophos | Calcineurin-like phosphoesterase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 4-Layer Sandwich | Purple Acid Phosphatase; chain A, domain 2 | Purple Acid Phosphatase; chain A, domain 2 |
#chains in the Genus database with same CATH superfamily 1IT6 A; 1II7 A; 1QFC A; 2YVT A; 1FJM A; 2Z1A A; 3H64 A; 5GTU A; 2HY1 A; 4KKZ A; 2XMO A; 4JA9 A; 2R17 A; 4LU9 A; 3H60 A; 4JA7 A; 3IB7 A; 4O4K A; 1S8E A; 3THO B; 1HO5 A; 2BDX A; 4B2O A; 2NYM C; 2NXF A; 4IL1 A; 3DSD A; 4MOV A; 3JYF A; 1OI8 A; 4MP0 A; 4O43 A; 4M0V A; 3HVQ A; 2JOG A; 3C5W C; 1Z2W A; 2USH A; 5B8I A; 1TCO A; 4HD0 A; 4H2G A; 2Z72 A; 5INB A; 4G9J A; 2A22 A; 1T71 A; 3H61 A; 4DT2 A; 3H68 A; 4I5L C; 4LAC C; 4MOY A; 2CV9 A; 3EGH A; 3H67 A; 4UT3 B; 2ZBM A; 1S3L A; 1AUI A; 3T1I A; 3H66 A; 2O8G A; 4I5N C; 2HYP A; 2O8A A; 5C1V A; 1Z2X A; 4KBP A; 2DFJ A; 4NZV A; 3QFK A; 3ZU0 A; 4WWL A; 4TUI A; 3E7A A; 4UWQ A; 4H1Y P; 2P6B A; 4LTY A; 4UT3 A; 3CK2 A; 3IB8 A; 1QHW A; 1SU1 A; 3RL3 A; 4H1S A; 3QG5 C; 2Q8U A; 1S3N A; 4O5G A; 4H2F A; 2AHD A; 3RL4 A; 1WAO 1; 2BCD A; 3K7V C; 1OID A; 5JPF A; 2QFR A; 3V4Y A; 4OR9 A; 3H62 B; 2IAE C; 4Q7F A; 1OIE A; 2BQ8 X; 3ICF A; 3IVE A; 4DHL A; 3H63 A; 3THN A; 4XPN A; 4DSY A; 2IE3 C; 4FCX A; 1M63 A; 3IVD A; 1U32 A; 2WDD A; 1UF3 A; 4UT2 A; 4V0W A; 5JPE A; 5HPE A; 4F0Z A; 4H2I A; 4FBQ A; 2QFP A; 3DW8 C; 1V73 A; 1XZW A; 3C9F A; 3H69 A; 4TUG A; 2GJU A; 1S3M A; 4FBW A; 3RQZ A; 3TGH A; 3QFO A; 2WDC A; 4ORC A; 4ZVZ A; 3DSC A; 4FBK A; 3AV0 A; 4ORB A; 1G5B A; 1W24 A; 2NPP C; 3AUZ A; 2HYO A; 3QFN A; 3K7W C; 3N5U A; 5EQV A; 4IYP C; 1UTE A; 3RL5 A; 1MF8 A; 2KKN A; 1NNW A; 4ZX2 A; 1S70 A; 3E7B A; 3FGA C; 1JK7 A; 3QFM A; 1KBP A; 1XM7 A; 5DNY A; 3PSO A; 3EGG A; 1WAR A; 3LL8 A; 4J6O A; 4O24 A; 4YKE A; 5JJT A; 5J28 A; 3ZTV A; 4V0V A; 1USH A; 3PSN A; 1HPU A; 2QJC A; 2WDF A; 5F3W A; 1T70 A; 5IOH A; 2Z06 A; 4ORA A; 2WDE A; 2NYL C; 4V0X A; 2IE4 C; 3GVE A; 3KBP A; 1S95 A; 4H2B A; 3P71 C; 1HP1 A; #chains in the Genus database with same CATH topology 1IT6 A; 1II7 A; 1QFC A; 2YVT A; 1FJM A; 2Z1A A; 3H64 A; 5GTU A; 2HY1 A; 4KKZ A; 2XMO A; 4JA9 A; 2R17 A; 4LU9 A; 3H60 A; 4JA7 A; 3IB7 A; 4O4K A; 1S8E A; 3THO B; 1HO5 A; 2BDX A; 4B2O A; 2NYM C; 2NXF A; 4IL1 A; 3DSD A; 4MOV A; 3JYF A; 1OI8 A; 4MP0 A; 4O43 A; 4M0V A; 3HVQ A; 2JOG A; 3C5W C; 1Z2W A; 2USH A; 5B8I A; 1TCO A; 4HD0 A; 4H2G A; 2Z72 A; 5INB A; 4G9J A; 2A22 A; 1T71 A; 3H61 A; 4DT2 A; 3H68 A; 4I5L C; 4LAC C; 4MOY A; 2CV9 A; 3EGH A; 3H67 A; 4UT3 B; 2ZBM A; 1S3L A; 1AUI A; 3T1I A; 3H66 A; 2O8G A; 4I5N C; 2HYP A; 2O8A A; 5C1V A; 1Z2X A; 4KBP A; 2DFJ A; 4NZV A; 3QFK A; 3ZU0 A; 4WWL A; 4TUI A; 3E7A A; 4UWQ A; 4H1Y P; 2P6B A; 4LTY A; 4UT3 A; 3CK2 A; 3IB8 A; 1QHW A; 2DXN A; 1SU1 A; 3RL3 A; 4H1S A; 3QG5 C; 2Q8U A; 1S3N A; 4O5G A; 4H2F A; 2AHD A; 3RL4 A; 1WAO 1; 2BCD A; 3K7V C; 1OID A; 5JPF A; 2QFR A; 3V4Y A; 4OR9 A; 3H62 B; 2IAE C; 4Q7F A; 1OIE A; 2BQ8 X; 3ICF A; 3IVE A; 4DHL A; 3H63 A; 3THN A; 4XPN A; 4DSY A; 2IE3 C; 4FCX A; 1M63 A; 3IVD A; 1U32 A; 2WDD A; 1UF3 A; 4UT2 A; 4V0W A; 5JPE A; 5HPE A; 2DXL A; 4F0Z A; 4H2I A; 3E0J A; 2QFP A; 3DW8 C; 1V73 A; 1XZW A; 3C9F A; 4FBQ A; 3H69 A; 4TUG A; 2GJU A; 1S3M A; 2YEQ A; 4FBW A; 3RQZ A; 3TGH A; 3QFO A; 2WDC A; 4ORC A; 4ZVZ A; 3DSC A; 3D03 A; 3AV0 A; 4FBK A; 4ORB A; 1G5B A; 1W24 A; 2NPP C; 3AUZ A; 2HYO A; 3QFN A; 3K7W C; 3N5U A; 5EQV A; 4IYP C; 1UTE A; 3RL5 A; 1MF8 A; 2KKN A; 1NNW A; 4ZX2 A; 1S70 A; 3E7B A; 3FGA C; 1JK7 A; 3FLO A; 3QFM A; 1KBP A; 1XM7 A; 5DNY A; 3PSO A; 3EGG A; 1WAR A; 3LL8 A; 4J6O A; 4O24 A; 4YKE A; 5JJT A; 5J28 A; 3ZTV A; 4V0V A; 1USH A; 2ZOA A; 3PSN A; 1HPU A; 2QJC A; 2WDF A; 5F3W A; 1T70 A; 5IOH A; 2Z06 A; 4ORA A; 2WDE A; 2NYL C; 4V0X A; 2IE4 C; 3GVE A; 3KBP A; 1S95 A; 4H2B A; 3P71 C; 1HP1 A; 2ZO9 B; #chains in the Genus database with same CATH homology 1IT6 A; 1II7 A; 1QFC A; 2YVT A; 1FJM A; 2Z1A A; 3H64 A; 5GTU A; 2HY1 A; 4KKZ A; 2XMO A; 4JA9 A; 2R17 A; 4LU9 A; 3H60 A; 4JA7 A; 3IB7 A; 4O4K A; 1S8E A; 3THO B; 1HO5 A; 2BDX A; 4B2O A; 2NYM C; 2NXF A; 4IL1 A; 3DSD A; 4MOV A; 3JYF A; 1OI8 A; 4MP0 A; 4O43 A; 4M0V A; 3HVQ A; 2JOG A; 3C5W C; 1Z2W A; 2USH A; 5B8I A; 1TCO A; 4HD0 A; 4H2G A; 2Z72 A; 5INB A; 4G9J A; 2A22 A; 1T71 A; 3H61 A; 4DT2 A; 3H68 A; 4I5L C; 4LAC C; 4MOY A; 2CV9 A; 3EGH A; 3H67 A; 4UT3 B; 2ZBM A; 1S3L A; 1AUI A; 3T1I A; 3H66 A; 2O8G A; 4I5N C; 2HYP A; 2O8A A; 5C1V A; 1Z2X A; 4KBP A; 2DFJ A; 4NZV A; 3QFK A; 3ZU0 A; 4WWL A; 4TUI A; 3E7A A; 4UWQ A; 4H1Y P; 2P6B A; 4LTY A; 4UT3 A; 3CK2 A; 3IB8 A; 1QHW A; 2DXN A; 1SU1 A; 3RL3 A; 4H1S A; 3QG5 C; 2Q8U A; 1S3N A; 4O5G A; 4H2F A; 2AHD A; 3RL4 A; 1WAO 1; 2BCD A; 3K7V C; 1OID A; 5JPF A; 2QFR A; 3V4Y A; 4OR9 A; 3H62 B; 2IAE C; 4Q7F A; 1OIE A; 2BQ8 X; 3ICF A; 3IVE A; 4DHL A; 3H63 A; 3THN A; 4XPN A; 4DSY A; 2IE3 C; 4FCX A; 1M63 A; 3IVD A; 1U32 A; 2WDD A; 1UF3 A; 4UT2 A; 4V0W A; 5JPE A; 5HPE A; 2DXL A; 4F0Z A; 4H2I A; 3E0J A; 2QFP A; 3DW8 C; 1V73 A; 1XZW A; 3C9F A; 4FBQ A; 3H69 A; 4TUG A; 2GJU A; 1S3M A; 2YEQ A; 4FBW A; 3RQZ A; 3TGH A; 3QFO A; 2WDC A; 4ORC A; 4ZVZ A; 3DSC A; 3D03 A; 3AV0 A; 4FBK A; 4ORB A; 1G5B A; 1W24 A; 2NPP C; 3AUZ A; 2HYO A; 3QFN A; 3K7W C; 3N5U A; 5EQV A; 4IYP C; 1UTE A; 3RL5 A; 1MF8 A; 2KKN A; 1NNW A; 4ZX2 A; 1S70 A; 3E7B A; 3FGA C; 1JK7 A; 3FLO A; 3QFM A; 1KBP A; 1XM7 A; 5DNY A; 3PSO A; 3EGG A; 1WAR A; 3LL8 A; 4J6O A; 4O24 A; 4YKE A; 5JJT A; 5J28 A; 3ZTV A; 4V0V A; 1USH A; 2ZOA A; 3PSN A; 1HPU A; 2QJC A; 2WDF A; 5F3W A; 1T70 A; 5IOH A; 2Z06 A; 4ORA A; 2WDE A; 2NYL C; 4V0X A; 2IE4 C; 3GVE A; 3KBP A; 1S95 A; 4H2B A; 3P71 C; 1HP1 A; 2ZO9 B;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
