1S95A

Structure of serine/threonine protein phosphatase 5
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
324
structure length
324
Chain Sequence
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine protein phosphatase 5
total genus 115
structure length 324
sequence length 324
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2004-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1s95A00
4LTYA 2KKNA 3DSDA 4ORAA 1V73A 4Q7FA 4UT2A 1OIEA 4O5GA 2HYOA 2BCDA 3QFKA 5JPEA 2HY1A 5JPFA 4MP0A 2DFJA 4H2BA 3FGAC 3H69A 2USHA 5DNYA 1JK7A 1S3MA 3H68A 4TUGA 1QHWA 4JA7A 4O43A 2BQ8X 3K7VC 5EQVA 4KBPA 2ZBMA 1U32A 3C9FA 3P71C 1T71A 4NZVA 3EGGA 2NYLC 1HO5A 3ZU0A 2O8AA 1SU1A 1M63A 2GJUA 2IE3C 3CK2A 3E7AA 3H66A 4UT3B 4H2GA 4DSYA 2YVTA 4M0VA 4HD0A 3QFMA 1QFCA 4IYPC 4H1YP 2O8GA 2XMOA 4DHLA 3THOB 4TUIA 2Z1AA 3IB7A 3DSCA 1T70A 3V4YA 2NYMC 4UT3A 2QFRA 1S8EA 4FBWA 2WDEA 3H61A 4O4KA 1II7A 3AUZA 2CV9A 4J6OA 2WDDA 1UF3A 4WWLA 3HVQA 4FBQA 1Z2WA 2QFPA 3H67A 4LU9A 4ORCA 3DW8C 4H2FA 1HPUA 4DT2A 4V0WA 3RL4A 3QFOA 4YKEA 1UTEA 4ORBA 2WDCA 1HP1A 4I5LC 2NXFA 3THNA 2NPPC 1S95A 3PSNA 4LACC 2IAEC 4H1SA 5IOHA 2Z72A 3KBPA 3C5WC 5HPEA 3QFNA 3RQZA 3IB8A 4F0ZA 3H62B 4KKZA 1FJMA 1WAO1 1MF8A 3K7WC 2BDXA 1S3LA 1USHA 3GVEA 1XZWA 3H63A 3QG5C 5B8IA 4IL1A 2HYPA 3N5UA 2AHDA 1IT6A 3JYFA 5GTUA 4B2OA 2R17A 3RL3A 3H60A 2IE4C 1S3NA 3AV0A 5INBA 4ZX2A 2JOGA 4UWQA 3E7BA 3IVDA 4V0VA 3ZTVA 2Q8UA 2A22A 2Z06A 4O24A 1NNWA 1G5BA 3LL8A 1WARA 4ZVZA 5F3WA 3TGHA 4G9JA 1KBPA 2WDFA 1AUIA 2QJCA 3T1IA 1Z2XA 4FCXA 4H2IA 5J28A 1XM7A 2P6BA 1W24A 3RL5A 4OR9A 4V0XA 3ICFA 5JJTA 4FBKA 5C1VA 1TCOA 1OIDA 1S70A 1OI8A 4MOYA 4I5NC 3IVEA 3H64A 3EGHA 3PSOA 4JA9A 4XPNA 4MOVA
chains in the Genus database with same CATH superfamily
4LTYA 2KKNA 3DSDA 4ORAA 1V73A 4Q7FA 4UT2A 1OIEA 4O5GA 2HYOA 2BCDA 3QFKA 5JPEA 2HY1A 5JPFA 4MP0A 2DFJA 4H2BA 3FGAC 3H69A 2USHA 5DNYA 1JK7A 1S3MA 3H68A 4TUGA 1QHWA 4JA7A 4O43A 2BQ8X 3K7VC 5EQVA 4KBPA 2ZBMA 1U32A 3C9FA 3P71C 1T71A 4NZVA 3EGGA 2NYLC 1HO5A 3ZU0A 2O8AA 1SU1A 1M63A 2GJUA 2IE3C 3CK2A 3E7AA 3H66A 4UT3B 4H2GA 4DSYA 2YVTA 4M0VA 4HD0A 3QFMA 1QFCA 4IYPC 4H1YP 2O8GA 2XMOA 4DHLA 3THOB 4TUIA 2Z1AA 3IB7A 3DSCA 1T70A 2ZOAA 3V4YA 2NYMC 4UT3A 2QFRA 1S8EA 4FBWA 2WDEA 3H61A 4O4KA 1II7A 3AUZA 2CV9A 4J6OA 2WDDA 1UF3A 4WWLA 3HVQA 4FBQA 1Z2WA 2QFPA 3H67A 4LU9A 4ORCA 3FLOA 3DW8C 4H2FA 1HPUA 4DT2A 4V0WA 3RL4A 3QFOA 4YKEA 1UTEA 4ORBA 2WDCA 3D03A 1HP1A 4I5LC 2NXFA 3THNA 2NPPC 1S95A 3PSNA 4LACC 2IAEC 4H1SA 5IOHA 2Z72A 3KBPA 3C5WC 5HPEA 3QFNA 3RQZA 3IB8A 4F0ZA 3H62B 4KKZA 2ZO9B 1FJMA 1WAO1 1MF8A 3K7WC 2BDXA 1S3LA 1USHA 3GVEA 1XZWA 3H63A 3QG5C 5B8IA 4IL1A 2HYPA 3N5UA 2AHDA 1IT6A 3JYFA 5GTUA 4B2OA 2R17A 3RL3A 3H60A 2IE4C 1S3NA 3AV0A 5INBA 4ZX2A 2JOGA 4UWQA 3E7BA 3IVDA 4V0VA 3ZTVA 2Q8UA 2A22A 2Z06A 4O24A 2DXLA 1NNWA 1G5BA 3LL8A 1WARA 4ZVZA 5F3WA 3E0JA 3TGHA 4G9JA 2DXNA 1KBPA 2WDFA 1AUIA 2QJCA 3T1IA 1Z2XA 4FCXA 4H2IA 5J28A 1XM7A 2P6BA 1W24A 3RL5A 4OR9A 4V0XA 3ICFA 5JJTA 4FBKA 5C1VA 2YEQA 1TCOA 1OIDA 1S70A 1OI8A 4MOYA 4I5NC 3IVEA 3H64A 3EGHA 3PSOA 4JA9A 4XPNA 4MOVA
chains in the Genus database with same CATH topology
4LTYA 2KKNA 3DSDA 4ORAA 1V73A 4Q7FA 4UT2A 1OIEA 4O5GA 2HYOA 2BCDA 3QFKA 5JPEA 2HY1A 5JPFA 4MP0A 2DFJA 4H2BA 3FGAC 3H69A 2USHA 5DNYA 1JK7A 1S3MA 3H68A 4TUGA 1QHWA 4JA7A 4O43A 2BQ8X 3K7VC 5EQVA 4KBPA 2ZBMA 1U32A 3C9FA 3P71C 1T71A 4NZVA 3EGGA 2NYLC 1HO5A 3ZU0A 2O8AA 1SU1A 1M63A 2GJUA 2IE3C 3CK2A 3E7AA 3H66A 4UT3B 4H2GA 4DSYA 2YVTA 4M0VA 4HD0A 3QFMA 1QFCA 4IYPC 4H1YP 2O8GA 2XMOA 4DHLA 3THOB 4TUIA 2Z1AA 3IB7A 3DSCA 1T70A 2ZOAA 3V4YA 2NYMC 4UT3A 2QFRA 1S8EA 4FBWA 2WDEA 3H61A 4O4KA 1II7A 3AUZA 2CV9A 4J6OA 2WDDA 1UF3A 4WWLA 3HVQA 4FBQA 1Z2WA 2QFPA 3H67A 4LU9A 4ORCA 3FLOA 3DW8C 4H2FA 1HPUA 4DT2A 4V0WA 3RL4A 3QFOA 4YKEA 1UTEA 4ORBA 2WDCA 3D03A 1HP1A 4I5LC 2NXFA 3THNA 2NPPC 1S95A 3PSNA 4LACC 2IAEC 4H1SA 5IOHA 2Z72A 3KBPA 3C5WC 5HPEA 3QFNA 3RQZA 3IB8A 4F0ZA 3H62B 4KKZA 2ZO9B 1FJMA 1WAO1 1MF8A 3K7WC 2BDXA 1S3LA 1USHA 3GVEA 1XZWA 3H63A 3QG5C 5B8IA 4IL1A 2HYPA 3N5UA 2AHDA 1IT6A 3JYFA 5GTUA 4B2OA 2R17A 3RL3A 3H60A 2IE4C 1S3NA 3AV0A 5INBA 4ZX2A 2JOGA 4UWQA 3E7BA 3IVDA 4V0VA 3ZTVA 2Q8UA 2A22A 2Z06A 4O24A 2DXLA 1NNWA 1G5BA 3LL8A 1WARA 4ZVZA 5F3WA 3E0JA 3TGHA 4G9JA 2DXNA 1KBPA 2WDFA 1AUIA 2QJCA 3T1IA 1Z2XA 4FCXA 4H2IA 5J28A 1XM7A 2P6BA 1W24A 3RL5A 4OR9A 4V0XA 3ICFA 5JJTA 4FBKA 5C1VA 2YEQA 1TCOA 1OIDA 1S70A 1OI8A 4MOYA 4I5NC 3IVEA 3H64A 3EGHA 3PSOA 4JA9A 4XPNA 4MOVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LTY A;  2KKN A;  3DSD A;  4ORA A;  1V73 A;  4Q7F A;  4UT2 A;  1OIE A;  4O5G A;  2HYO A;  2BCD A;  3QFK A;  5JPE A;  2HY1 A;  5JPF A;  4MP0 A;  2DFJ A;  4H2B A;  3FGA C;  3H69 A;  2USH A;  5DNY A;  1JK7 A;  1S3M A;  3H68 A;  4TUG A;  1QHW A;  4JA7 A;  4O43 A;  2BQ8 X;  3K7V C;  5EQV A;  4KBP A;  2ZBM A;  1U32 A;  3C9F A;  3P71 C;  1T71 A;  4NZV A;  3EGG A;  2NYL C;  1HO5 A;  3ZU0 A;  2O8A A;  1SU1 A;  1M63 A;  2GJU A;  2IE3 C;  3CK2 A;  3E7A A;  3H66 A;  4UT3 B;  4H2G A;  4DSY A;  2YVT A;  4M0V A;  4HD0 A;  3QFM A;  1QFC A;  4IYP C;  4H1Y P;  2O8G A;  2XMO A;  4DHL A;  3THO B;  4TUI A;  2Z1A A;  3IB7 A;  3DSC A;  1T70 A;  3V4Y A;  2NYM C;  4UT3 A;  2QFR A;  1S8E A;  4FBW A;  2WDE A;  3H61 A;  4O4K A;  1II7 A;  3AUZ A;  2CV9 A;  4J6O A;  2WDD A;  1UF3 A;  4WWL A;  3HVQ A;  4FBQ A;  1Z2W A;  2QFP A;  3H67 A;  4LU9 A;  4ORC A;  3DW8 C;  4H2F A;  1HPU A;  4DT2 A;  4V0W A;  3RL4 A;  3QFO A;  4YKE A;  1UTE A;  4ORB A;  2WDC A;  1HP1 A;  4I5L C;  2NXF A;  3THN A;  2NPP C;  1S95 A;  3PSN A;  4LAC C;  2IAE C;  4H1S A;  5IOH A;  2Z72 A;  3KBP A;  3C5W C;  5HPE A;  3QFN A;  3RQZ A;  3IB8 A;  4F0Z A;  3H62 B;  4KKZ A;  1FJM A;  1WAO 1;  1MF8 A;  3K7W C;  2BDX A;  1S3L A;  1USH A;  3GVE A;  1XZW A;  3H63 A;  3QG5 C;  5B8I A;  4IL1 A;  2HYP A;  3N5U A;  2AHD A;  1IT6 A;  3JYF A;  5GTU A;  4B2O A;  2R17 A;  3RL3 A;  3H60 A;  2IE4 C;  1S3N A;  3AV0 A;  5INB A;  4ZX2 A;  2JOG A;  4UWQ A;  3E7B A;  3IVD A;  4V0V A;  3ZTV A;  2Q8U A;  2A22 A;  2Z06 A;  4O24 A;  1NNW A;  1G5B A;  3LL8 A;  1WAR A;  4ZVZ A;  5F3W A;  3TGH A;  4G9J A;  1KBP A;  2WDF A;  1AUI A;  2QJC A;  3T1I A;  1Z2X A;  4FCX A;  4H2I A;  5J28 A;  1XM7 A;  2P6B A;  1W24 A;  3RL5 A;  4OR9 A;  4V0X A;  3ICF A;  5JJT A;  4FBK A;  5C1V A;  1TCO A;  1OID A;  1S70 A;  1OI8 A;  4MOY A;  4I5N C;  3IVE A;  3H64 A;  3EGH A;  3PSO A;  4JA9 A;  4XPN A;  4MOV A; 
#chains in the Genus database with same CATH topology
 4LTY A;  2KKN A;  3DSD A;  4ORA A;  1V73 A;  4Q7F A;  4UT2 A;  1OIE A;  4O5G A;  2HYO A;  2BCD A;  3QFK A;  5JPE A;  2HY1 A;  5JPF A;  4MP0 A;  2DFJ A;  4H2B A;  3FGA C;  3H69 A;  2USH A;  5DNY A;  1JK7 A;  1S3M A;  3H68 A;  4TUG A;  1QHW A;  4JA7 A;  4O43 A;  2BQ8 X;  3K7V C;  5EQV A;  4KBP A;  2ZBM A;  1U32 A;  3C9F A;  3P71 C;  1T71 A;  4NZV A;  3EGG A;  2NYL C;  1HO5 A;  3ZU0 A;  2O8A A;  1SU1 A;  1M63 A;  2GJU A;  2IE3 C;  3CK2 A;  3E7A A;  3H66 A;  4UT3 B;  4H2G A;  4DSY A;  2YVT A;  4M0V A;  4HD0 A;  3QFM A;  1QFC A;  4IYP C;  4H1Y P;  2O8G A;  2XMO A;  4DHL A;  3THO B;  4TUI A;  2Z1A A;  3IB7 A;  3DSC A;  1T70 A;  2ZOA A;  3V4Y A;  2NYM C;  4UT3 A;  2QFR A;  1S8E A;  4FBW A;  2WDE A;  3H61 A;  4O4K A;  1II7 A;  3AUZ A;  2CV9 A;  4J6O A;  2WDD A;  1UF3 A;  4WWL A;  3HVQ A;  4FBQ A;  1Z2W A;  2QFP A;  3H67 A;  4LU9 A;  4ORC A;  3FLO A;  3DW8 C;  4H2F A;  1HPU A;  4DT2 A;  4V0W A;  3RL4 A;  3QFO A;  4YKE A;  1UTE A;  4ORB A;  2WDC A;  3D03 A;  1HP1 A;  4I5L C;  2NXF A;  3THN A;  2NPP C;  1S95 A;  3PSN A;  4LAC C;  2IAE C;  4H1S A;  5IOH A;  2Z72 A;  3KBP A;  3C5W C;  5HPE A;  3QFN A;  3RQZ A;  3IB8 A;  4F0Z A;  3H62 B;  4KKZ A;  2ZO9 B;  1FJM A;  1WAO 1;  1MF8 A;  3K7W C;  2BDX A;  1S3L A;  1USH A;  3GVE A;  1XZW A;  3H63 A;  3QG5 C;  5B8I A;  4IL1 A;  2HYP A;  3N5U A;  2AHD A;  1IT6 A;  3JYF A;  5GTU A;  4B2O A;  2R17 A;  3RL3 A;  3H60 A;  2IE4 C;  1S3N A;  3AV0 A;  5INB A;  4ZX2 A;  2JOG A;  4UWQ A;  3E7B A;  3IVD A;  4V0V A;  3ZTV A;  2Q8U A;  2A22 A;  2Z06 A;  4O24 A;  2DXL A;  1NNW A;  1G5B A;  3LL8 A;  1WAR A;  4ZVZ A;  5F3W A;  3E0J A;  3TGH A;  4G9J A;  2DXN A;  1KBP A;  2WDF A;  1AUI A;  2QJC A;  3T1I A;  1Z2X A;  4FCX A;  4H2I A;  5J28 A;  1XM7 A;  2P6B A;  1W24 A;  3RL5 A;  4OR9 A;  4V0X A;  3ICF A;  5JJT A;  4FBK A;  5C1V A;  2YEQ A;  1TCO A;  1OID A;  1S70 A;  1OI8 A;  4MOY A;  4I5N C;  3IVE A;  3H64 A;  3EGH A;  3PSO A;  4JA9 A;  4XPN A;  4MOV A; 
#chains in the Genus database with same CATH homology
 4LTY A;  2KKN A;  3DSD A;  4ORA A;  1V73 A;  4Q7F A;  4UT2 A;  1OIE A;  4O5G A;  2HYO A;  2BCD A;  3QFK A;  5JPE A;  2HY1 A;  5JPF A;  4MP0 A;  2DFJ A;  4H2B A;  3FGA C;  3H69 A;  2USH A;  5DNY A;  1JK7 A;  1S3M A;  3H68 A;  4TUG A;  1QHW A;  4JA7 A;  4O43 A;  2BQ8 X;  3K7V C;  5EQV A;  4KBP A;  2ZBM A;  1U32 A;  3C9F A;  3P71 C;  1T71 A;  4NZV A;  3EGG A;  2NYL C;  1HO5 A;  3ZU0 A;  2O8A A;  1SU1 A;  1M63 A;  2GJU A;  2IE3 C;  3CK2 A;  3E7A A;  3H66 A;  4UT3 B;  4H2G A;  4DSY A;  2YVT A;  4M0V A;  4HD0 A;  3QFM A;  1QFC A;  4IYP C;  4H1Y P;  2O8G A;  2XMO A;  4DHL A;  3THO B;  4TUI A;  2Z1A A;  3IB7 A;  3DSC A;  1T70 A;  2ZOA A;  3V4Y A;  2NYM C;  4UT3 A;  2QFR A;  1S8E A;  4FBW A;  2WDE A;  3H61 A;  4O4K A;  1II7 A;  3AUZ A;  2CV9 A;  4J6O A;  2WDD A;  1UF3 A;  4WWL A;  3HVQ A;  4FBQ A;  1Z2W A;  2QFP A;  3H67 A;  4LU9 A;  4ORC A;  3FLO A;  3DW8 C;  4H2F A;  1HPU A;  4DT2 A;  4V0W A;  3RL4 A;  3QFO A;  4YKE A;  1UTE A;  4ORB A;  2WDC A;  3D03 A;  1HP1 A;  4I5L C;  2NXF A;  3THN A;  2NPP C;  1S95 A;  3PSN A;  4LAC C;  2IAE C;  4H1S A;  5IOH A;  2Z72 A;  3KBP A;  3C5W C;  5HPE A;  3QFN A;  3RQZ A;  3IB8 A;  4F0Z A;  3H62 B;  4KKZ A;  2ZO9 B;  1FJM A;  1WAO 1;  1MF8 A;  3K7W C;  2BDX A;  1S3L A;  1USH A;  3GVE A;  1XZW A;  3H63 A;  3QG5 C;  5B8I A;  4IL1 A;  2HYP A;  3N5U A;  2AHD A;  1IT6 A;  3JYF A;  5GTU A;  4B2O A;  2R17 A;  3RL3 A;  3H60 A;  2IE4 C;  1S3N A;  3AV0 A;  5INB A;  4ZX2 A;  2JOG A;  4UWQ A;  3E7B A;  3IVD A;  4V0V A;  3ZTV A;  2Q8U A;  2A22 A;  2Z06 A;  4O24 A;  2DXL A;  1NNW A;  1G5B A;  3LL8 A;  1WAR A;  4ZVZ A;  5F3W A;  3E0J A;  3TGH A;  4G9J A;  2DXN A;  1KBP A;  2WDF A;  1AUI A;  2QJC A;  3T1I A;  1Z2X A;  4FCX A;  4H2I A;  5J28 A;  1XM7 A;  2P6B A;  1W24 A;  3RL5 A;  4OR9 A;  4V0X A;  3ICF A;  5JJT A;  4FBK A;  5C1V A;  2YEQ A;  1TCO A;  1OID A;  1S70 A;  1OI8 A;  4MOY A;  4I5N C;  3IVE A;  3H64 A;  3EGH A;  3PSO A;  4JA9 A;  4XPN A;  4MOV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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