1TWCL

Rna polymerase ii complexed with gtp
Total Genus 0
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
0
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 1twcL00
4A3JL 2B63L 3S2DL 4Y52L 3S15L 2Y0SP 4A3IL 1Y1VL 2JA7L 1I6HL 5M5WL 3GTLL 4A3FL 3RZDL 1TWHL 1I3QL 4BY7L 1TWGL 5IYDL 5FJ8L 2WB1P 5M3ML 4BY1L 1SFOL 2R92L 3S1RL 1R9TL 2R93L 2NVQL 3S1QL 2JA5L 1TWFL 2JA8L 4X6AL 3HOZL 1Y1WL 1K83L 1TWAL 4BXXL 3GTPL 5IYCL 2R7ZL 1WCML 5IP7L 3HOWL 5IYBL 4A93L 5C3EL 5C4JL 3H3VM 3GTJL 3FKIL 5IP9L 4BBSL 3S17L 3GTQL 3CQZL 2NVTL 3M3YL 3S1ML 3HOXL 1I50L 3S14L 4QIWP 3RZOL 5C4XL 3M4OL 3I4ML 3GTML 2E2JL 2NVYL 2PMZP 4A3LL 3S1NL 3S2HL 3GTGL 3H0GL 4A3EL 2E2HL 4A3DL 4C2M1 3HOVL 4A3BL 4C3IL 4AYBP 4C3HL 3PO3L 5M5YL 4A3ML 3GTOL 3I4NL 3HKZP 3GTKL 2YU9L 3HOYL 2VUML 5FLML 2NVXL 2JA6L 4Y7NL 1TWCL 4C3JL 3PO2L 2WAQP 5M5XL 4A3CL 5C44L 3HOUL 5M3FL 3S16L 2E2IL 4A3GL 4BBRL 3K7AL 4A3KL
chains in the Genus database with same CATH superfamily
2B63L 4K9FA 3MPSA 4YWMA 1R0FA 4A3IL 1Y1VL 2C6AA 1VCXA 5EINC 3PIP1 1VZIA 4YWLA 2M6PA 2O5JD 1WJVA 5GAEc 1IU6A 5IYDL 1T9QA 1RB9A 4BY1L 2R92L 1IROA 4RXNA 1R9TL 2NVQL 2JA8L 1QQTA 3HOZL 2V0EA 4AR5A 3LWOB 2C6BA 5IYCL 5IP7L 2XJSA 1BQ8A 5IYBL 5C3EL 1ODHA 3H3VM 4BBSL 3S17L 1P7PA 1LTLA 5AI3A 3M3YL 3S14L 2L0ZA 5MLC3 4LHLA 3M4OL 3I4ML 3KYWA 3LWQB 3GTML 3MSUA 1H7VA 2PMZP 1YK4A 2XJPA 3K35A 3GTGL 3H0GL 1RDGA 4C2M1 2M6OA 4AHXA 3QVDA 2KN9A 4V196 4JAFA 3PKIA 4JAEA 3GTKL 1LKMA 3HOYL 5GAHc 5MF6A 4C3JL 2WAQP 5M5XL 1NXGA 5MFPA 3S16L 2A69D 2E2IL 1VZGA 1RYQA 1Z92B 4Y52L 2CKAA 1S30A 4AR4A 4GS7D 4AI1A 1BFYA 2V3BB 4U671 5M5WL 1YV1A 3B0AB 3GTLL 3JR7A 4BY7L 1TWGL 3PL5A 2M4VA 4B8CD 5M3ML 3P8BA 3S1RL 5AN9H 2JA5L 2QL0A 1Y1WL 4BXXL 2R7ZL 3LWVB 1OWCA 1SMWA 4AHYA 1T9PA 3B08B 2A6HD 1BRFA 3GTJL 5K2ME 3CQZL 2J9UB 2NVTL 2XJUA 3LWPB 1ZRPA 3RZ6A 1I50L 2XJQA 3KYVA 2CKCA 3A44A 2EY4E 2H12A 4AR3A 6RXNA 1FHMA 2MS3A 1T9OA 4ZN1B 1OWBA 1R0HA 5MFZA 2HVYC 3PKJA 4A3EL 2E2HL 1B2JA 4A3DL 4POGA 4A3BL 4C3IL 1JYBA 5JVH1 3GTOL 1B13A 4LHNA 2JI2A 1PFUA 5GADc 2RFKB 1B71A 1YK5A 5FLML 3VPBE 4WFN1 4Y7NL 1TWCL 4A3CL 5M3FL 2Z3QB 3KYUA 2APOB 3PIO1 4BBRL 1PFWA 3K7AL 3IU3I 2PYAA 2XJRA 3NFPI 1PZXA 1RWDA 4UY81 8RXNA 3S15L 1I6HL 5DM71 3FDJA 2AUSB 2XJTA 3QQCE 4A3FL 1I3QL 2GMGA 5FJ8L 1IU5A 3ZG6A 1QYBA 2R93L 3S1QL 1TWFL 1CAAA 2PVXA 3WWLA 3MQKB 1K83L 1BQ9A 3GTPL 3J7Y1 1F4LA 3HOWL 7RXNA 4G6BA 1DX8A 3HJYB 4AI0A 1S24A 1NNQA 3WWNB 4AI2A 5IP9L 2RDVA 1QCVA 2ZIXA 5MGNA 3HOXL 3S1ML 1IRNA 4AR6A 1LKPA 4QIWP 3RZOL 1RDVA 2LCQA 2E2JL 2JI3A 4AHWA 1E8JA 5JVG1 3HOVL 2PVEA 2JI1A 3LNLA 4C3HL 1DVBA 2VL6A 1BE7A 1YUXA 3HKZP 3SS2A 3KYYA 2M4YA 3J7Z1 2JA6L 3H9CA 2Z3RB 5C44L 5EIOC 3LPEB 2NYDA 4A3JL 3S2DL 2Y0SP 1YUZA 4AI3A 2JA7L 5AI2A 4XXBB 3RYGA 1VZHA 3HAXC 3RZDL 1TWHL 2AQCA 1S2ZA 1R0JA 1LKOA 1PFVA 2DSXA 1CADA 2WB1P 3PWFA 1SFOL 2A68D 1R0IA 2CR8A 4X6AL 1RYTA 1TWAL 5DM61 4JAGA 1WCML 5RXNA 1FHHA 4TPUA 4A93L 1B2OA 2HR5A 2PPTA 5C4JL 5IY0A 2PSMC 1NXEA 1PFYA 4XGHA 3PZAA 1R0GA 3FKIL 3GTQL 2XJVA 2ERJA 5H1Sc 4ZN3B 1SMMA 2ERSA 5C4XL 3RZTA 4E6YA 2NVYL 2AYJA 4A3LL 3S1NL 3S2HL 3H9BA 4AHZA 1C09A 4POFA 2K2DA 2B5ID 4AYBP 3PO3L 2KKDA 4TVMA 3P2AA 5M5YL 4A3ML 3I4NL 2YU9L 3H97A 3KYXA 5GAGc 2VUML 2NVXL 4ME3A 3PO2L 1IW7D 3H99A 2V0FA 2A6ED 3HOUL 4JADA 2BE5D 4A3GL 3LWRB 1SMUA 3HJWB 4A3KL
chains in the Genus database with same CATH topology
4A3JL 2B63L 3S2DL 4Y52L 3S15L 2Y0SP 4A3IL 1Y1VL 2JA7L 1I6HL 5M5WL 3GTLL 4A3FL 3RZDL 1TWHL 1I3QL 4BY7L 1TWGL 5IYDL 5FJ8L 2WB1P 5M3ML 4BY1L 1SFOL 2R92L 3S1RL 1R9TL 2R93L 2NVQL 3S1QL 2JA5L 1TWFL 2JA8L 4X6AL 3HOZL 1Y1WL 1K83L 1TWAL 4BXXL 3GTPL 5IYCL 2R7ZL 1WCML 5IP7L 3HOWL 5IYBL 4A93L 5C3EL 5C4JL 3H3VM 3GTJL 3FKIL 5IP9L 4BBSL 3S17L 3GTQL 3CQZL 2NVTL 3M3YL 3S1ML 3HOXL 1I50L 3S14L 4QIWP 3RZOL 5C4XL 3M4OL 3I4ML 3GTML 2E2JL 2NVYL 2PMZP 4A3LL 3S1NL 3S2HL 3GTGL 3H0GL 4A3EL 2E2HL 4A3DL 4C2M1 3HOVL 4A3BL 4C3IL 4AYBP 4C3HL 3PO3L 5M5YL 4A3ML 3GTOL 3I4NL 3HKZP 3GTKL 2YU9L 3HOYL 2VUML 5FLML 2NVXL 2JA6L 4Y7NL 1TWCL 4C3JL 3PO2L 2WAQP 5M5XL 4A3CL 5C44L 3HOUL 5M3FL 3S16L 2E2IL 4A3GL 4BBRL 3K7AL 4A3KL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3J L;  2B63 L;  3S2D L;  4Y52 L;  3S15 L;  2Y0S P;  4A3I L;  1Y1V L;  2JA7 L;  1I6H L;  5M5W L;  3GTL L;  4A3F L;  3RZD L;  1TWH L;  1I3Q L;  4BY7 L;  1TWG L;  5IYD L;  5FJ8 L;  2WB1 P;  5M3M L;  4BY1 L;  1SFO L;  2R92 L;  3S1R L;  1R9T L;  2R93 L;  2NVQ L;  3S1Q L;  2JA5 L;  1TWF L;  2JA8 L;  4X6A L;  3HOZ L;  1Y1W L;  1K83 L;  1TWA L;  4BXX L;  3GTP L;  5IYC L;  2R7Z L;  1WCM L;  5IP7 L;  3HOW L;  5IYB L;  4A93 L;  5C3E L;  5C4J L;  3H3V M;  3GTJ L;  3FKI L;  5IP9 L;  4BBS L;  3S17 L;  3GTQ L;  3CQZ L;  2NVT L;  3M3Y L;  3S1M L;  3HOX L;  1I50 L;  3S14 L;  4QIW P;  3RZO L;  5C4X L;  3M4O L;  3I4M L;  3GTM L;  2E2J L;  2NVY L;  2PMZ P;  4A3L L;  3S1N L;  3S2H L;  3GTG L;  3H0G L;  4A3E L;  2E2H L;  4A3D L;  4C2M 1;  3HOV L;  4A3B L;  4C3I L;  4AYB P;  4C3H L;  3PO3 L;  5M5Y L;  4A3M L;  3GTO L;  3I4N L;  3HKZ P;  3GTK L;  2YU9 L;  3HOY L;  2VUM L;  5FLM L;  2NVX L;  2JA6 L;  4Y7N L;  1TWC L;  4C3J L;  3PO2 L;  2WAQ P;  5M5X L;  4A3C L;  5C44 L;  3HOU L;  5M3F L;  3S16 L;  2E2I L;  4A3G L;  4BBR L;  3K7A L;  4A3K L; 
#chains in the Genus database with same CATH topology
 2B63 L;  4K9F A;  3MPS A;  4YWM A;  1R0F A;  4A3I L;  1Y1V L;  2C6A A;  1VCX A;  5EIN C;  3PIP 1;  1VZI A;  4YWL A;  2M6P A;  2O5J D;  1WJV A;  5GAE c;  1IU6 A;  5IYD L;  1T9Q A;  1RB9 A;  4BY1 L;  2R92 L;  1IRO A;  4RXN A;  1R9T L;  2NVQ L;  2JA8 L;  1QQT A;  3HOZ L;  2V0E A;  4AR5 A;  3LWO B;  2C6B A;  5IYC L;  5IP7 L;  2XJS A;  1BQ8 A;  5IYB L;  5C3E L;  1ODH A;  3H3V M;  4BBS L;  3S17 L;  1P7P A;  1LTL A;  5AI3 A;  3M3Y L;  3S14 L;  2L0Z A;  5MLC 3;  4LHL A;  3M4O L;  3I4M L;  3KYW A;  3LWQ B;  3GTM L;  3MSU A;  1H7V A;  2PMZ P;  1YK4 A;  2XJP A;  3K35 A;  3GTG L;  3H0G L;  1RDG A;  4C2M 1;  2M6O A;  4AHX A;  3QVD A;  2KN9 A;  4V19 6;  4JAF A;  3PKI A;  4JAE A;  3GTK L;  1LKM A;  3HOY L;  5GAH c;  5MF6 A;  4C3J L;  2WAQ P;  5M5X L;  1NXG A;  5MFP A;  3S16 L;  2A69 D;  2E2I L;  1VZG A;  1RYQ A;  1Z92 B;  4Y52 L;  2CKA A;  1S30 A;  4AR4 A;  4GS7 D;  4AI1 A;  1BFY A;  2V3B B;  4U67 1;  5M5W L;  1YV1 A;  3B0A B;  3GTL L;  3JR7 A;  4BY7 L;  1TWG L;  3PL5 A;  2M4V A;  4B8C D;  5M3M L;  3P8B A;  3S1R L;  5AN9 H;  2JA5 L;  2QL0 A;  1Y1W L;  4BXX L;  2R7Z L;  3LWV B;  1OWC A;  1SMW A;  4AHY A;  1T9P A;  3B08 B;  2A6H D;  1BRF A;  3GTJ L;  5K2M E;  3CQZ L;  2J9U B;  2NVT L;  2XJU A;  3LWP B;  1ZRP A;  3RZ6 A;  1I50 L;  2XJQ A;  3KYV A;  2CKC A;  3A44 A;  2EY4 E;  2H12 A;  4AR3 A;  6RXN A;  1FHM A;  2MS3 A;  1T9O A;  4ZN1 B;  1OWB A;  1R0H A;  5MFZ A;  2HVY C;  3PKJ A;  4A3E L;  2E2H L;  1B2J A;  4A3D L;  4POG A;  4A3B L;  4C3I L;  1JYB A;  5JVH 1;  3GTO L;  1B13 A;  4LHN A;  2JI2 A;  1PFU A;  5GAD c;  2RFK B;  1B71 A;  1YK5 A;  5FLM L;  3VPB E;  4WFN 1;  4Y7N L;  1TWC L;  4A3C L;  5M3F L;  2Z3Q B;  3KYU A;  2APO B;  3PIO 1;  4BBR L;  1PFW A;  3K7A L;  3IU3 I;  2PYA A;  2XJR A;  3NFP I;  1PZX A;  1RWD A;  4UY8 1;  8RXN A;  3S15 L;  1I6H L;  5DM7 1;  3FDJ A;  2AUS B;  2XJT A;  3QQC E;  4A3F L;  1I3Q L;  2GMG A;  5FJ8 L;  1IU5 A;  3ZG6 A;  1QYB A;  2R93 L;  3S1Q L;  1TWF L;  1CAA A;  2PVX A;  3WWL A;  3MQK B;  1K83 L;  1BQ9 A;  3GTP L;  3J7Y 1;  1F4L A;  3HOW L;  7RXN A;  4G6B A;  1DX8 A;  3HJY B;  4AI0 A;  1S24 A;  1NNQ A;  3WWN B;  4AI2 A;  5IP9 L;  2RDV A;  1QCV A;  2ZIX A;  5MGN A;  3HOX L;  3S1M L;  1IRN A;  4AR6 A;  1LKP A;  4QIW P;  3RZO L;  1RDV A;  2LCQ A;  2E2J L;  2JI3 A;  4AHW A;  1E8J A;  5JVG 1;  3HOV L;  2PVE A;  2JI1 A;  3LNL A;  4C3H L;  1DVB A;  2VL6 A;  1BE7 A;  1YUX A;  3HKZ P;  3SS2 A;  3KYY A;  2M4Y A;  3J7Z 1;  2JA6 L;  3H9C A;  2Z3R B;  5C44 L;  5EIO C;  3LPE B;  2NYD A;  4A3J L;  3S2D L;  2Y0S P;  1YUZ A;  4AI3 A;  2JA7 L;  5AI2 A;  4XXB B;  3RYG A;  1VZH A;  3HAX C;  3RZD L;  1TWH L;  2AQC A;  1S2Z A;  1R0J A;  1LKO A;  1PFV A;  2DSX A;  1CAD A;  2WB1 P;  3PWF A;  1SFO L;  2A68 D;  1R0I A;  2CR8 A;  4X6A L;  1RYT A;  1TWA L;  5DM6 1;  4JAG A;  1WCM L;  5RXN A;  1FHH A;  4TPU A;  4A93 L;  1B2O A;  2HR5 A;  2PPT A;  5C4J L;  5IY0 A;  2PSM C;  1NXE A;  1PFY A;  4XGH A;  3PZA A;  1R0G A;  3FKI L;  3GTQ L;  2XJV A;  2ERJ A;  5H1S c;  4ZN3 B;  1SMM A;  2ERS A;  5C4X L;  3RZT A;  4E6Y A;  2NVY L;  2AYJ A;  4A3L L;  3S1N L;  3S2H L;  3H9B A;  4AHZ A;  1C09 A;  4POF A;  2K2D A;  2B5I D;  4AYB P;  3PO3 L;  2KKD A;  4TVM A;  3P2A A;  5M5Y L;  4A3M L;  3I4N L;  2YU9 L;  3H97 A;  3KYX A;  5GAG c;  2VUM L;  2NVX L;  4ME3 A;  3PO2 L;  1IW7 D;  3H99 A;  2V0F A;  2A6E D;  3HOU L;  4JAD A;  2BE5 D;  4A3G L;  3LWR B;  1SMU A;  3HJW B;  4A3K L; 
#chains in the Genus database with same CATH homology
 4A3J L;  2B63 L;  3S2D L;  4Y52 L;  3S15 L;  2Y0S P;  4A3I L;  1Y1V L;  2JA7 L;  1I6H L;  5M5W L;  3GTL L;  4A3F L;  3RZD L;  1TWH L;  1I3Q L;  4BY7 L;  1TWG L;  5IYD L;  5FJ8 L;  2WB1 P;  5M3M L;  4BY1 L;  1SFO L;  2R92 L;  3S1R L;  1R9T L;  2R93 L;  2NVQ L;  3S1Q L;  2JA5 L;  1TWF L;  2JA8 L;  4X6A L;  3HOZ L;  1Y1W L;  1K83 L;  1TWA L;  4BXX L;  3GTP L;  5IYC L;  2R7Z L;  1WCM L;  5IP7 L;  3HOW L;  5IYB L;  4A93 L;  5C3E L;  5C4J L;  3H3V M;  3GTJ L;  3FKI L;  5IP9 L;  4BBS L;  3S17 L;  3GTQ L;  3CQZ L;  2NVT L;  3M3Y L;  3S1M L;  3HOX L;  1I50 L;  3S14 L;  4QIW P;  3RZO L;  5C4X L;  3M4O L;  3I4M L;  3GTM L;  2E2J L;  2NVY L;  2PMZ P;  4A3L L;  3S1N L;  3S2H L;  3GTG L;  3H0G L;  4A3E L;  2E2H L;  4A3D L;  4C2M 1;  3HOV L;  4A3B L;  4C3I L;  4AYB P;  4C3H L;  3PO3 L;  5M5Y L;  4A3M L;  3GTO L;  3I4N L;  3HKZ P;  3GTK L;  2YU9 L;  3HOY L;  2VUM L;  5FLM L;  2NVX L;  2JA6 L;  4Y7N L;  1TWC L;  4C3J L;  3PO2 L;  2WAQ P;  5M5X L;  4A3C L;  5C44 L;  3HOU L;  5M3F L;  3S16 L;  2E2I L;  4A3G L;  4BBR L;  3K7A L;  4A3K L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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