3CQZL

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
45
structure length
43
Chain Sequence
TLKYICAECSSKLSLSRTDAVRCCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 3
structure length 43
sequence length 45
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 3cqzL00
2WB1P 1SFOL 5C4XL 4A3LL 1I3QL 3GTJL 3S1QL 3FKIL 3GTPL 3GTML 4A3JL 3GTQL 1TWGL 5FLML 5M5XL 4A93L 5M5WL 2JA5L 4C2M1 2WAQP 4Y52L 1TWFL 3S1ML 3S2HL 3K7AL 3M4OL 2E2HL 1R9TL 3GTLL 4BXXL 2JA6L 1I50L 5M5YL 3GTGL 2JA8L 3GTOL 4BBRL 4X6AL 1Y1WL 2NVTL 2E2JL 1TWAL 2Y0SP 2R93L 5IYBL 4A3CL 3HOXL 5IYCL 2YU9L 5M3ML 4BY1L 4QIWP 4A3GL 2NVQL 2VUML 3S14L 3HOWL 1WCML 2R92L 3GTKL 4A3BL 4A3KL 1TWHL 3H0GL 5C44L 5IYDL 5IP7L 4C3HL 4C3JL 4A3EL 3HKZP 4Y7NL 4A3FL 3PO3L 4A3DL 1TWCL 3I4NL 3HOYL 3S16L 3S1NL 3S2DL 4BBSL 4AYBP 2B63L 3HOVL 2NVXL 5C4JL 3I4ML 4A3IL 1Y1VL 3S15L 3S17L 2R7ZL 2NVYL 3CQZL 4BY7L 3RZDL 2JA7L 2PMZP 3M3YL 3PO2L 3S1RL 3RZOL 3HOZL 3HOUL 1K83L 5IP9L 5C3EL 3H3VM 4C3IL 1I6HL 2E2IL 4A3ML 5FJ8L 5M3FL
chains in the Genus database with same CATH superfamily
2XJQA 1NXGA 4YWMA 4A3LL 3HAXC 4TVMA 3GTPL 5FLML 5M5WL 3PWFA 4Y52L 1OWCA 3MQKB 2M4YA 2APOB 4ZN1B 3B0AB 1SMWA 4BXXL 5M5YL 5GAHc 2JA8L 3GTOL 1NXEA 2E2JL 5IYBL 3HOXL 4AHXA 5RXNA 4JAFA 4AHZA 4AI3A 3WWNB 4UY81 2VUML 3HOWL 1DVBA 1FHMA 3PKIA 1ZRPA 5IYDL 5H1Sc 1FHHA 5MFPA 4GS7D 1T9PA 2KKDA 3PO3L 4AI1A 1B13A 5JVH1 3S1NL 3S2DL 3PIO1 1CAAA 1PZXA 4JAEA 3I4ML 4A3IL 1C09A 1DX8A 5AI3A 3S17L 2HR5A 1F4LA 5GADc 3PO2L 1LKOA 3HOUL 2Z3RB 2B5ID 5C3EL 1PFYA 4POFA 4V196 4A3ML 1RWDA 4AR3A 1R0HA 2XJUA 1S30A 3NFPI 5C4XL 4AR6A 4K9FA 3GTQL 1SMUA 2NYDA 5M5XL 5DM71 4A93L 4RXNA 2JA5L 4C2M1 4AI0A 2WAQP 1TWFL 3B08B 3S2HL 2C6BA 2DSXA 1T9OA 4AI2A 1R9TL 3LWOB 2CKAA 3GTGL 3KYWA 3P2AA 4X6AL 1S2ZA 2C6AA 1RDGA 1IU6A 2ERSA 5IYCL 2YU9L 5EINC 4LHLA 2V0FA 8RXNA 1LKMA 1RYQA 2R92L 1IW7D 2VL6A 1PFVA 5C44L 3H0GL 1JYBA 4XXBB 3LPEB 4C3HL 3QVDA 2XJVA 3H99A 1QQTA 4AR5A 1P7PA 4Y7NL 4A3FL 3RYGA 3LWRB 4A3DL 3IU3I 4G6BA 3VPBE 2MS3A 3HOYL 2V3BB 3PL5A 1PFWA 5DM61 4BBSL 2NVXL 2PVXA 3RZ6A 4B8CD 5MGNA 1YUZA 1H7VA 2PVEA 2AYJA 2GMGA 2AQCA 2A68D 3HOZL 1RB9A 5EIOC 2ERJA 2A6HD 2EY4E 2K2DA 5M3FL 2WB1P 2M4VA 1SFOL 1I3QL 2O5JD 4A3JL 2XJRA 5GAGc 2L0ZA 2XJPA 2CKCA 2XJTA 4XGHA 2RDVA 1IU5A 3S1ML 1R0JA 3K7AL 3M4OL 2E2HL 2XJSA 2M6OA 5GAEc 4JAGA 4BBRL 1Y1WL 1B71A 1IRNA 1TWAL 1S24A 2R93L 1LTLA 1RYTA 5MLC3 3J7Y1 5M3ML 1OWBA 3MPSA 2PPTA 4A3GL 2NVQL 2A69D 4YWLA 1QCVA 4A3KL 5AN9H 4AHYA 2ZIXA 3A44A 1ODHA 5IP7L 6RXNA 4C3JL 3MSUA 7RXNA 3H97A 3H9BA 1TWCL 3I4NL 1YK4A 5AI2A 2H12A 1B2JA 2J9UB 3S16L 3HJWB 3KYVA 3HOVL 2CR8A 1T9QA 5K2ME 1Y1VL 4WFN1 5IY0A 3LWVB 3PZAA 2JI3A 2NVYL 3CQZL 3KYYA 3RZDL 3H9CA 4LHNA 3SS2A 2QL0A 3M3YL 3S1RL 2HVYC 5IP9L 3H3VM 1CADA 2LCQA 4TPUA 1I6HL 1YK5A 1E8JA 1VZHA 5FJ8L 1VCXA 4AHWA 4ZN3B 3FDJA 3GTJL 3S1QL 3FKIL 1R0GA 3LWPB 3GTML 2Z3QB 1R0IA 1TWGL 1IROA 2RFKB 1VZGA 4ME3A 1BQ8A 1BRFA 1B2OA 2PSMC 1QYBA 3GTLL 2V0EA 4E6YA 2JA6L 1I50L 2BE5D 3K35A 1YUXA 2NVTL 3RZTA 2PYAA 3P8BA 4U671 2Y0SP 4A3CL 3ZG6A 5MF6A 1R0FA 4AR4A 5MFZA 4BY1L 1WJVA 3JR7A 4QIWP 3QQCE 3S14L 2JI1A 1WCML 3GTKL 3PKJA 2M6PA 4A3BL 1TWHL 5JVG1 1PFUA 3HJYB 3LNLA 2AUSB 4A3EL 3HKZP 1BFYA 2A6ED 4POGA 1YV1A 4AYBP 2JI2A 2B63L 1SMMA 1Z92B 3WWLA 5C4JL 2KN9A 1NNQA 1VZIA 3S15L 3KYUA 2R7ZL 1LKPA 1BQ9A 4BY7L 2JA7L 2PMZP 3J7Z1 1BE7A 3RZOL 3LWQB 4JADA 1K83L 3KYXA 3PIP1 4C3IL 2E2IL 1RDVA
chains in the Genus database with same CATH topology
2WB1P 1SFOL 5C4XL 4A3LL 1I3QL 3GTJL 3S1QL 3FKIL 3GTPL 3GTML 4A3JL 3GTQL 1TWGL 5FLML 5M5XL 4A93L 5M5WL 2JA5L 4C2M1 2WAQP 4Y52L 1TWFL 3S1ML 3S2HL 3K7AL 3M4OL 2E2HL 1R9TL 3GTLL 4BXXL 2JA6L 1I50L 5M5YL 3GTGL 2JA8L 3GTOL 4BBRL 4X6AL 1Y1WL 2NVTL 2E2JL 1TWAL 2Y0SP 2R93L 5IYBL 4A3CL 3HOXL 5IYCL 2YU9L 5M3ML 4BY1L 4QIWP 4A3GL 2NVQL 2VUML 3S14L 3HOWL 1WCML 2R92L 3GTKL 4A3BL 4A3KL 1TWHL 3H0GL 5C44L 5IYDL 5IP7L 4C3HL 4C3JL 4A3EL 3HKZP 4Y7NL 4A3FL 3PO3L 4A3DL 1TWCL 3I4NL 3HOYL 3S16L 3S1NL 3S2DL 4BBSL 4AYBP 2B63L 3HOVL 2NVXL 5C4JL 3I4ML 4A3IL 1Y1VL 3S15L 3S17L 2R7ZL 2NVYL 3CQZL 4BY7L 3RZDL 2JA7L 2PMZP 3M3YL 3PO2L 3S1RL 3RZOL 3HOZL 3HOUL 1K83L 5IP9L 5C3EL 3H3VM 4C3IL 1I6HL 2E2IL 4A3ML 5FJ8L 5M3FL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WB1 P;  1SFO L;  5C4X L;  4A3L L;  1I3Q L;  3GTJ L;  3S1Q L;  3FKI L;  3GTP L;  3GTM L;  4A3J L;  3GTQ L;  1TWG L;  5FLM L;  5M5X L;  4A93 L;  5M5W L;  2JA5 L;  4C2M 1;  2WAQ P;  4Y52 L;  1TWF L;  3S1M L;  3S2H L;  3K7A L;  3M4O L;  2E2H L;  1R9T L;  3GTL L;  4BXX L;  2JA6 L;  1I50 L;  5M5Y L;  3GTG L;  2JA8 L;  3GTO L;  4BBR L;  4X6A L;  1Y1W L;  2NVT L;  2E2J L;  1TWA L;  2Y0S P;  2R93 L;  5IYB L;  4A3C L;  3HOX L;  5IYC L;  2YU9 L;  5M3M L;  4BY1 L;  4QIW P;  4A3G L;  2NVQ L;  2VUM L;  3S14 L;  3HOW L;  1WCM L;  2R92 L;  3GTK L;  4A3B L;  4A3K L;  1TWH L;  3H0G L;  5C44 L;  5IYD L;  5IP7 L;  4C3H L;  4C3J L;  4A3E L;  3HKZ P;  4Y7N L;  4A3F L;  3PO3 L;  4A3D L;  1TWC L;  3I4N L;  3HOY L;  3S16 L;  3S1N L;  3S2D L;  4BBS L;  4AYB P;  2B63 L;  3HOV L;  2NVX L;  5C4J L;  3I4M L;  4A3I L;  1Y1V L;  3S15 L;  3S17 L;  2R7Z L;  2NVY L;  3CQZ L;  4BY7 L;  3RZD L;  2JA7 L;  2PMZ P;  3M3Y L;  3PO2 L;  3S1R L;  3RZO L;  3HOZ L;  3HOU L;  1K83 L;  5IP9 L;  5C3E L;  3H3V M;  4C3I L;  1I6H L;  2E2I L;  4A3M L;  5FJ8 L;  5M3F L; 
#chains in the Genus database with same CATH topology
 2XJQ A;  1NXG A;  4YWM A;  4A3L L;  3HAX C;  4TVM A;  3GTP L;  5FLM L;  5M5W L;  3PWF A;  4Y52 L;  1OWC A;  3MQK B;  2M4Y A;  2APO B;  4ZN1 B;  3B0A B;  1SMW A;  4BXX L;  5M5Y L;  5GAH c;  2JA8 L;  3GTO L;  1NXE A;  2E2J L;  5IYB L;  3HOX L;  4AHX A;  5RXN A;  4JAF A;  4AHZ A;  4AI3 A;  3WWN B;  4UY8 1;  2VUM L;  3HOW L;  1DVB A;  1FHM A;  3PKI A;  1ZRP A;  5IYD L;  5H1S c;  1FHH A;  5MFP A;  4GS7 D;  1T9P A;  2KKD A;  3PO3 L;  4AI1 A;  1B13 A;  5JVH 1;  3S1N L;  3S2D L;  3PIO 1;  1CAA A;  1PZX A;  4JAE A;  3I4M L;  4A3I L;  1C09 A;  1DX8 A;  5AI3 A;  3S17 L;  2HR5 A;  1F4L A;  5GAD c;  3PO2 L;  1LKO A;  3HOU L;  2Z3R B;  2B5I D;  5C3E L;  1PFY A;  4POF A;  4V19 6;  4A3M L;  1RWD A;  4AR3 A;  1R0H A;  2XJU A;  1S30 A;  3NFP I;  5C4X L;  4AR6 A;  4K9F A;  3GTQ L;  1SMU A;  2NYD A;  5M5X L;  5DM7 1;  4A93 L;  4RXN A;  2JA5 L;  4C2M 1;  4AI0 A;  2WAQ P;  1TWF L;  3B08 B;  3S2H L;  2C6B A;  2DSX A;  1T9O A;  4AI2 A;  1R9T L;  3LWO B;  2CKA A;  3GTG L;  3KYW A;  3P2A A;  4X6A L;  1S2Z A;  2C6A A;  1RDG A;  1IU6 A;  2ERS A;  5IYC L;  2YU9 L;  5EIN C;  4LHL A;  2V0F A;  8RXN A;  1LKM A;  1RYQ A;  2R92 L;  1IW7 D;  2VL6 A;  1PFV A;  5C44 L;  3H0G L;  1JYB A;  4XXB B;  3LPE B;  4C3H L;  3QVD A;  2XJV A;  3H99 A;  1QQT A;  4AR5 A;  1P7P A;  4Y7N L;  4A3F L;  3RYG A;  3LWR B;  4A3D L;  3IU3 I;  4G6B A;  3VPB E;  2MS3 A;  3HOY L;  2V3B B;  3PL5 A;  1PFW A;  5DM6 1;  4BBS L;  2NVX L;  2PVX A;  3RZ6 A;  4B8C D;  5MGN A;  1YUZ A;  1H7V A;  2PVE A;  2AYJ A;  2GMG A;  2AQC A;  2A68 D;  3HOZ L;  1RB9 A;  5EIO C;  2ERJ A;  2A6H D;  2EY4 E;  2K2D A;  5M3F L;  2WB1 P;  2M4V A;  1SFO L;  1I3Q L;  2O5J D;  4A3J L;  2XJR A;  5GAG c;  2L0Z A;  2XJP A;  2CKC A;  2XJT A;  4XGH A;  2RDV A;  1IU5 A;  3S1M L;  1R0J A;  3K7A L;  3M4O L;  2E2H L;  2XJS A;  2M6O A;  5GAE c;  4JAG A;  4BBR L;  1Y1W L;  1B71 A;  1IRN A;  1TWA L;  1S24 A;  2R93 L;  1LTL A;  1RYT A;  5MLC 3;  3J7Y 1;  5M3M L;  1OWB A;  3MPS A;  2PPT A;  4A3G L;  2NVQ L;  2A69 D;  4YWL A;  1QCV A;  4A3K L;  5AN9 H;  4AHY A;  2ZIX A;  3A44 A;  1ODH A;  5IP7 L;  6RXN A;  4C3J L;  3MSU A;  7RXN A;  3H97 A;  3H9B A;  1TWC L;  3I4N L;  1YK4 A;  5AI2 A;  2H12 A;  1B2J A;  2J9U B;  3S16 L;  3HJW B;  3KYV A;  3HOV L;  2CR8 A;  1T9Q A;  5K2M E;  1Y1V L;  4WFN 1;  5IY0 A;  3LWV B;  3PZA A;  2JI3 A;  2NVY L;  3CQZ L;  3KYY A;  3RZD L;  3H9C A;  4LHN A;  3SS2 A;  2QL0 A;  3M3Y L;  3S1R L;  2HVY C;  5IP9 L;  3H3V M;  1CAD A;  2LCQ A;  4TPU A;  1I6H L;  1YK5 A;  1E8J A;  1VZH A;  5FJ8 L;  1VCX A;  4AHW A;  4ZN3 B;  3FDJ A;  3GTJ L;  3S1Q L;  3FKI L;  1R0G A;  3LWP B;  3GTM L;  2Z3Q B;  1R0I A;  1TWG L;  1IRO A;  2RFK B;  1VZG A;  4ME3 A;  1BQ8 A;  1BRF A;  1B2O A;  2PSM C;  1QYB A;  3GTL L;  2V0E A;  4E6Y A;  2JA6 L;  1I50 L;  2BE5 D;  3K35 A;  1YUX A;  2NVT L;  3RZT A;  2PYA A;  3P8B A;  4U67 1;  2Y0S P;  4A3C L;  3ZG6 A;  5MF6 A;  1R0F A;  4AR4 A;  5MFZ A;  4BY1 L;  1WJV A;  3JR7 A;  4QIW P;  3QQC E;  3S14 L;  2JI1 A;  1WCM L;  3GTK L;  3PKJ A;  2M6P A;  4A3B L;  1TWH L;  5JVG 1;  1PFU A;  3HJY B;  3LNL A;  2AUS B;  4A3E L;  3HKZ P;  1BFY A;  2A6E D;  4POG A;  1YV1 A;  4AYB P;  2JI2 A;  2B63 L;  1SMM A;  1Z92 B;  3WWL A;  5C4J L;  2KN9 A;  1NNQ A;  1VZI A;  3S15 L;  3KYU A;  2R7Z L;  1LKP A;  1BQ9 A;  4BY7 L;  2JA7 L;  2PMZ P;  3J7Z 1;  1BE7 A;  3RZO L;  3LWQ B;  4JAD A;  1K83 L;  3KYX A;  3PIP 1;  4C3I L;  2E2I L;  1RDV A; 
#chains in the Genus database with same CATH homology
 2WB1 P;  1SFO L;  5C4X L;  4A3L L;  1I3Q L;  3GTJ L;  3S1Q L;  3FKI L;  3GTP L;  3GTM L;  4A3J L;  3GTQ L;  1TWG L;  5FLM L;  5M5X L;  4A93 L;  5M5W L;  2JA5 L;  4C2M 1;  2WAQ P;  4Y52 L;  1TWF L;  3S1M L;  3S2H L;  3K7A L;  3M4O L;  2E2H L;  1R9T L;  3GTL L;  4BXX L;  2JA6 L;  1I50 L;  5M5Y L;  3GTG L;  2JA8 L;  3GTO L;  4BBR L;  4X6A L;  1Y1W L;  2NVT L;  2E2J L;  1TWA L;  2Y0S P;  2R93 L;  5IYB L;  4A3C L;  3HOX L;  5IYC L;  2YU9 L;  5M3M L;  4BY1 L;  4QIW P;  4A3G L;  2NVQ L;  2VUM L;  3S14 L;  3HOW L;  1WCM L;  2R92 L;  3GTK L;  4A3B L;  4A3K L;  1TWH L;  3H0G L;  5C44 L;  5IYD L;  5IP7 L;  4C3H L;  4C3J L;  4A3E L;  3HKZ P;  4Y7N L;  4A3F L;  3PO3 L;  4A3D L;  1TWC L;  3I4N L;  3HOY L;  3S16 L;  3S1N L;  3S2D L;  4BBS L;  4AYB P;  2B63 L;  3HOV L;  2NVX L;  5C4J L;  3I4M L;  4A3I L;  1Y1V L;  3S15 L;  3S17 L;  2R7Z L;  2NVY L;  3CQZ L;  4BY7 L;  3RZD L;  2JA7 L;  2PMZ P;  3M3Y L;  3PO2 L;  3S1R L;  3RZO L;  3HOZ L;  3HOU L;  1K83 L;  5IP9 L;  5C3E L;  3H3V M;  4C3I L;  1I6H L;  2E2I L;  4A3M L;  5FJ8 L;  5M3F L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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