1TWHL

Rna polymerase ii complexed with 2'datp
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
total genus 1
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 1twhL00
3S14L 4AYBP 5IYDL 4C3IL 4BY1L 1K83L 1TWFL 1I50L 4C2M1 3M3YL 3H3VM 5C44L 2Y0SP 4BXXL 3RZOL 3S17L 3HOUL 3H0GL 3S2DL 3GTGL 2NVXL 4QIWP 5C4XL 5FJ8L 4C3HL 4BBSL 2R93L 5FLML 2R7ZL 3I4ML 1SFOL 1I6HL 3RZDL 3FKIL 4X6AL 4A3IL 3I4NL 4A3KL 5C4JL 2YU9L 2B63L 5M3FL 4A3CL 2JA6L 3GTKL 4BY7L 4BBRL 1TWCL 2WAQP 5IP7L 2WB1P 3M4OL 2R92L 3GTJL 4A3FL 4A3EL 4A3JL 5IYBL 5M3ML 1R9TL 4A3DL 3HOZL 2NVYL 5IYCL 3S1QL 2E2HL 1I3QL 2E2IL 2JA5L 3S1NL 4C3JL 1TWAL 3HOWL 4A3BL 4A93L 2VUML 3HOYL 3PO2L 5M5YL 2NVQL 2JA8L 4A3ML 3S16L 3GTOL 3HOVL 3HOXL 1Y1WL 5C3EL 3GTLL 3CQZL 3S1RL 1WCML 1Y1VL 3GTQL 3HKZP 5IP9L 4A3LL 3S1ML 3PO3L 5M5WL 1TWGL 4Y7NL 4A3GL 3S15L 1TWHL 2E2JL 3K7AL 5M5XL 3S2HL 3GTPL 2NVTL 4Y52L 2PMZP 2JA7L 3GTML
chains in the Genus database with same CATH superfamily
3LPEB 4AYBP 4POGA 1ZRPA 5IYDL 1YK4A 5GAHc 5JVG1 4C3IL 1OWCA 1TWFL 3ZG6A 7RXNA 3M3YL 4G6BA 3H3VM 3PZAA 2Y0SP 1IROA 1CADA 4BXXL 3PIP1 4RXNA 3S17L 2RDVA 1C09A 3P2AA 4ME3A 3HOUL 3S2DL 4AI2A 4AI0A 5FJ8L 2EY4E 4GS7D 3KYVA 5AI2A 2K2DA 3J7Y1 3J7Z1 2R93L 5FLML 2R7ZL 3FKIL 4X6AL 3PKIA 4E6YA 4A3KL 2V0FA 1T9PA 3NFPI 2CKAA 4BBRL 2JI1A 5IP7L 2WB1P 1E8JA 3M4OL 2XJPA 3KYUA 1IRNA 3QQCE 4A3JL 5DM61 3RYGA 3WWLA 3HOZL 1FHMA 1I3QL 5MF6A 2E2IL 4YWMA 1R0JA 3S1NL 2H12A 3H9CA 3H9BA 2VUML 4V196 3LWPB 1CAAA 2JA8L 3FDJA 5C3EL 1IU6A 1Y1VL 5K2ME 3HJWB 6RXNA 2AUSB 4A3LL 1B71A 3S1ML 4AHWA 2PPTA 2A69D 4ZN3B 1VZHA 2HR5A 3JR7A 2PMZP 2DSXA 3S14L 2MS3A 1LKOA 2L0ZA 4BY1L 1PFVA 2XJSA 5MFPA 4XGHA 1BQ8A 4JADA 4AR4A 4QIWP 5MGNA 5C4XL 3KYWA 2VL6A 2ERJA 1BQ9A 1SFOL 1I6HL 1Z92B 1RB9A 5H1Sc 3MSUA 2PYAA 5C4JL 2YU9L 5M3FL 2JA6L 1QQTA 3GTKL 4TVMA 1S2ZA 4AR3A 3P8BA 1B2JA 2WAQP 4A3FL 4A3EL 1R0GA 5IYBL 4B8CD 1LKMA 3WWNB 1YK5A 2M6OA 2XJRA 3S1QL 2Z3RB 3LWQB 2E2HL 1PFWA 1PFUA 5AN9H 4C3JL 3HOWL 4JAEA 5MFZA 1R0IA 4AHYA 3HOYL 3PO2L 2NVQL 4JAFA 2J9UB 4JAGA 3S16L 3GTOL 1DX8A 1S30A 3GTLL 2ZIXA 2KKDA 4AHZA 2HVYC 3MQKB 3HKZP 2XJQA 1TWGL 4A3GL 3K35A 4LHLA 3K7AL 3S2HL 2XJTA 1PZXA 1S24A 1YV1A 1T9QA 4Y52L 1NXGA 3GTML 2XJVA 2APOB 4YWLA 1NXEA 1JYBA 2PVXA 3RZ6A 2QL0A 3H97A 1SMWA 2AYJA 3PWFA 1VCXA 3H0GL 3GTGL 2AQCA 1LTLA 2NYDA 4U671 2PSMC 2M4VA 5EINC 4BBSL 1WJVA 4AI3A 2RFKB 1BE7A 3RZDL 4A3IL 2JI2A 1OWBA 3LWVB 2A6HD 2KN9A 2R92L 1DVBA 3GTJL 4AI1A 1H7VA 5M3ML 2A6ED 2NVYL 1IW7D 1RDGA 2B5ID 5MLC3 1TWAL 1QCVA 4AHXA 5DM71 3KYXA 5M5YL 4A3ML 3LWRB 3HOVL 3RZTA 1B2OA 5GAGc 3S1RL 1WCML 2O5JD 5IP9L 1YUXA 4K9FA 3PO3L 4Y7NL 4ZN1B 5JVH1 2ERSA 3S15L 1TWHL 3HAXC 2E2JL 3B08B 3VPBE 5M5XL 2C6AA 2JA7L 3PL5A 3A44A 3H99A 4AR6A 1K83L 2Z3QB 2JI3A 1I50L 4POFA 5AI3A 4C2M1 5EIOC 1ODHA 5C44L 4LHNA 1SMUA 3PIO1 1SMMA 2M6PA 3RZOL 3PKJA 2XJUA 8RXNA 2LCQA 1QYBA 4UY81 4AR5A 2A68D 2NVXL 3SS2A 4WFN1 4C3HL 4TPUA 1PFYA 3LWOB 1VZIA 4XXBB 3I4ML 3MPSA 3I4NL 1R0HA 1YUZA 2B63L 2PVEA 2V3BB 4A3CL 1IU5A 4BY7L 3LNLA 1VZGA 1RDVA 2M4YA 1TWCL 1T9OA 1BRFA 1BFYA 2CKCA 1R0FA 1R9TL 4A3DL 2CR8A 3KYYA 1NNQA 5IYCL 5GAEc 1RWDA 1B13A 2JA5L 1P7PA 3HJYB 1FHHA 4A3BL 4A93L 5GADc 3IU3I 1RYQA 3HOXL 1Y1WL 1RYTA 3CQZL 3GTQL 3B0AB 2BE5D 5RXNA 2V0EA 5M5WL 1LKPA 5IY0A 2GMGA 3GTPL 2NVTL 3QVDA 1F4LA 2C6BA
chains in the Genus database with same CATH topology
3S14L 4AYBP 5IYDL 4C3IL 4BY1L 1K83L 1TWFL 1I50L 4C2M1 3M3YL 3H3VM 5C44L 2Y0SP 4BXXL 3RZOL 3S17L 3HOUL 3H0GL 3S2DL 3GTGL 2NVXL 4QIWP 5C4XL 5FJ8L 4C3HL 4BBSL 2R93L 5FLML 2R7ZL 3I4ML 1SFOL 1I6HL 3RZDL 3FKIL 4X6AL 4A3IL 3I4NL 4A3KL 5C4JL 2YU9L 2B63L 5M3FL 4A3CL 2JA6L 3GTKL 4BY7L 4BBRL 1TWCL 2WAQP 5IP7L 2WB1P 3M4OL 2R92L 3GTJL 4A3FL 4A3EL 4A3JL 5IYBL 5M3ML 1R9TL 4A3DL 3HOZL 2NVYL 5IYCL 3S1QL 2E2HL 1I3QL 2E2IL 2JA5L 3S1NL 4C3JL 1TWAL 3HOWL 4A3BL 4A93L 2VUML 3HOYL 3PO2L 5M5YL 2NVQL 2JA8L 4A3ML 3S16L 3GTOL 3HOVL 3HOXL 1Y1WL 5C3EL 3GTLL 3CQZL 3S1RL 1WCML 1Y1VL 3GTQL 3HKZP 5IP9L 4A3LL 3S1ML 3PO3L 5M5WL 1TWGL 4Y7NL 4A3GL 3S15L 1TWHL 2E2JL 3K7AL 5M5XL 3S2HL 3GTPL 2NVTL 4Y52L 2PMZP 2JA7L 3GTML
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S14 L;  4AYB P;  5IYD L;  4C3I L;  4BY1 L;  1K83 L;  1TWF L;  1I50 L;  4C2M 1;  3M3Y L;  3H3V M;  5C44 L;  2Y0S P;  4BXX L;  3RZO L;  3S17 L;  3HOU L;  3H0G L;  3S2D L;  3GTG L;  2NVX L;  4QIW P;  5C4X L;  5FJ8 L;  4C3H L;  4BBS L;  2R93 L;  5FLM L;  2R7Z L;  3I4M L;  1SFO L;  1I6H L;  3RZD L;  3FKI L;  4X6A L;  4A3I L;  3I4N L;  4A3K L;  5C4J L;  2YU9 L;  2B63 L;  5M3F L;  4A3C L;  2JA6 L;  3GTK L;  4BY7 L;  4BBR L;  1TWC L;  2WAQ P;  5IP7 L;  2WB1 P;  3M4O L;  2R92 L;  3GTJ L;  4A3F L;  4A3E L;  4A3J L;  5IYB L;  5M3M L;  1R9T L;  4A3D L;  3HOZ L;  2NVY L;  5IYC L;  3S1Q L;  2E2H L;  1I3Q L;  2E2I L;  2JA5 L;  3S1N L;  4C3J L;  1TWA L;  3HOW L;  4A3B L;  4A93 L;  2VUM L;  3HOY L;  3PO2 L;  5M5Y L;  2NVQ L;  2JA8 L;  4A3M L;  3S16 L;  3GTO L;  3HOV L;  3HOX L;  1Y1W L;  5C3E L;  3GTL L;  3CQZ L;  3S1R L;  1WCM L;  1Y1V L;  3GTQ L;  3HKZ P;  5IP9 L;  4A3L L;  3S1M L;  3PO3 L;  5M5W L;  1TWG L;  4Y7N L;  4A3G L;  3S15 L;  1TWH L;  2E2J L;  3K7A L;  5M5X L;  3S2H L;  3GTP L;  2NVT L;  4Y52 L;  2PMZ P;  2JA7 L;  3GTM L; 
#chains in the Genus database with same CATH topology
 3LPE B;  4AYB P;  4POG A;  1ZRP A;  5IYD L;  1YK4 A;  5GAH c;  5JVG 1;  4C3I L;  1OWC A;  1TWF L;  3ZG6 A;  7RXN A;  3M3Y L;  4G6B A;  3H3V M;  3PZA A;  2Y0S P;  1IRO A;  1CAD A;  4BXX L;  3PIP 1;  4RXN A;  3S17 L;  2RDV A;  1C09 A;  3P2A A;  4ME3 A;  3HOU L;  3S2D L;  4AI2 A;  4AI0 A;  5FJ8 L;  2EY4 E;  4GS7 D;  3KYV A;  5AI2 A;  2K2D A;  3J7Y 1;  3J7Z 1;  2R93 L;  5FLM L;  2R7Z L;  3FKI L;  4X6A L;  3PKI A;  4E6Y A;  4A3K L;  2V0F A;  1T9P A;  3NFP I;  2CKA A;  4BBR L;  2JI1 A;  5IP7 L;  2WB1 P;  1E8J A;  3M4O L;  2XJP A;  3KYU A;  1IRN A;  3QQC E;  4A3J L;  5DM6 1;  3RYG A;  3WWL A;  3HOZ L;  1FHM A;  1I3Q L;  5MF6 A;  2E2I L;  4YWM A;  1R0J A;  3S1N L;  2H12 A;  3H9C A;  3H9B A;  2VUM L;  4V19 6;  3LWP B;  1CAA A;  2JA8 L;  3FDJ A;  5C3E L;  1IU6 A;  1Y1V L;  5K2M E;  3HJW B;  6RXN A;  2AUS B;  4A3L L;  1B71 A;  3S1M L;  4AHW A;  2PPT A;  2A69 D;  4ZN3 B;  1VZH A;  2HR5 A;  3JR7 A;  2PMZ P;  2DSX A;  3S14 L;  2MS3 A;  1LKO A;  2L0Z A;  4BY1 L;  1PFV A;  2XJS A;  5MFP A;  4XGH A;  1BQ8 A;  4JAD A;  4AR4 A;  4QIW P;  5MGN A;  5C4X L;  3KYW A;  2VL6 A;  2ERJ A;  1BQ9 A;  1SFO L;  1I6H L;  1Z92 B;  1RB9 A;  5H1S c;  3MSU A;  2PYA A;  5C4J L;  2YU9 L;  5M3F L;  2JA6 L;  1QQT A;  3GTK L;  4TVM A;  1S2Z A;  4AR3 A;  3P8B A;  1B2J A;  2WAQ P;  4A3F L;  4A3E L;  1R0G A;  5IYB L;  4B8C D;  1LKM A;  3WWN B;  1YK5 A;  2M6O A;  2XJR A;  3S1Q L;  2Z3R B;  3LWQ B;  2E2H L;  1PFW A;  1PFU A;  5AN9 H;  4C3J L;  3HOW L;  4JAE A;  5MFZ A;  1R0I A;  4AHY A;  3HOY L;  3PO2 L;  2NVQ L;  4JAF A;  2J9U B;  4JAG A;  3S16 L;  3GTO L;  1DX8 A;  1S30 A;  3GTL L;  2ZIX A;  2KKD A;  4AHZ A;  2HVY C;  3MQK B;  3HKZ P;  2XJQ A;  1TWG L;  4A3G L;  3K35 A;  4LHL A;  3K7A L;  3S2H L;  2XJT A;  1PZX A;  1S24 A;  1YV1 A;  1T9Q A;  4Y52 L;  1NXG A;  3GTM L;  2XJV A;  2APO B;  4YWL A;  1NXE A;  1JYB A;  2PVX A;  3RZ6 A;  2QL0 A;  3H97 A;  1SMW A;  2AYJ A;  3PWF A;  1VCX A;  3H0G L;  3GTG L;  2AQC A;  1LTL A;  2NYD A;  4U67 1;  2PSM C;  2M4V A;  5EIN C;  4BBS L;  1WJV A;  4AI3 A;  2RFK B;  1BE7 A;  3RZD L;  4A3I L;  2JI2 A;  1OWB A;  3LWV B;  2A6H D;  2KN9 A;  2R92 L;  1DVB A;  3GTJ L;  4AI1 A;  1H7V A;  5M3M L;  2A6E D;  2NVY L;  1IW7 D;  1RDG A;  2B5I D;  5MLC 3;  1TWA L;  1QCV A;  4AHX A;  5DM7 1;  3KYX A;  5M5Y L;  4A3M L;  3LWR B;  3HOV L;  3RZT A;  1B2O A;  5GAG c;  3S1R L;  1WCM L;  2O5J D;  5IP9 L;  1YUX A;  4K9F A;  3PO3 L;  4Y7N L;  4ZN1 B;  5JVH 1;  2ERS A;  3S15 L;  1TWH L;  3HAX C;  2E2J L;  3B08 B;  3VPB E;  5M5X L;  2C6A A;  2JA7 L;  3PL5 A;  3A44 A;  3H99 A;  4AR6 A;  1K83 L;  2Z3Q B;  2JI3 A;  1I50 L;  4POF A;  5AI3 A;  4C2M 1;  5EIO C;  1ODH A;  5C44 L;  4LHN A;  1SMU A;  3PIO 1;  1SMM A;  2M6P A;  3RZO L;  3PKJ A;  2XJU A;  8RXN A;  2LCQ A;  1QYB A;  4UY8 1;  4AR5 A;  2A68 D;  2NVX L;  3SS2 A;  4WFN 1;  4C3H L;  4TPU A;  1PFY A;  3LWO B;  1VZI A;  4XXB B;  3I4M L;  3MPS A;  3I4N L;  1R0H A;  1YUZ A;  2B63 L;  2PVE A;  2V3B B;  4A3C L;  1IU5 A;  4BY7 L;  3LNL A;  1VZG A;  1RDV A;  2M4Y A;  1TWC L;  1T9O A;  1BRF A;  1BFY A;  2CKC A;  1R0F A;  1R9T L;  4A3D L;  2CR8 A;  3KYY A;  1NNQ A;  5IYC L;  5GAE c;  1RWD A;  1B13 A;  2JA5 L;  1P7P A;  3HJY B;  1FHH A;  4A3B L;  4A93 L;  5GAD c;  3IU3 I;  1RYQ A;  3HOX L;  1Y1W L;  1RYT A;  3CQZ L;  3GTQ L;  3B0A B;  2BE5 D;  5RXN A;  2V0E A;  5M5W L;  1LKP A;  5IY0 A;  2GMG A;  3GTP L;  2NVT L;  3QVD A;  1F4L A;  2C6B A; 
#chains in the Genus database with same CATH homology
 3S14 L;  4AYB P;  5IYD L;  4C3I L;  4BY1 L;  1K83 L;  1TWF L;  1I50 L;  4C2M 1;  3M3Y L;  3H3V M;  5C44 L;  2Y0S P;  4BXX L;  3RZO L;  3S17 L;  3HOU L;  3H0G L;  3S2D L;  3GTG L;  2NVX L;  4QIW P;  5C4X L;  5FJ8 L;  4C3H L;  4BBS L;  2R93 L;  5FLM L;  2R7Z L;  3I4M L;  1SFO L;  1I6H L;  3RZD L;  3FKI L;  4X6A L;  4A3I L;  3I4N L;  4A3K L;  5C4J L;  2YU9 L;  2B63 L;  5M3F L;  4A3C L;  2JA6 L;  3GTK L;  4BY7 L;  4BBR L;  1TWC L;  2WAQ P;  5IP7 L;  2WB1 P;  3M4O L;  2R92 L;  3GTJ L;  4A3F L;  4A3E L;  4A3J L;  5IYB L;  5M3M L;  1R9T L;  4A3D L;  3HOZ L;  2NVY L;  5IYC L;  3S1Q L;  2E2H L;  1I3Q L;  2E2I L;  2JA5 L;  3S1N L;  4C3J L;  1TWA L;  3HOW L;  4A3B L;  4A93 L;  2VUM L;  3HOY L;  3PO2 L;  5M5Y L;  2NVQ L;  2JA8 L;  4A3M L;  3S16 L;  3GTO L;  3HOV L;  3HOX L;  1Y1W L;  5C3E L;  3GTL L;  3CQZ L;  3S1R L;  1WCM L;  1Y1V L;  3GTQ L;  3HKZ P;  5IP9 L;  4A3L L;  3S1M L;  3PO3 L;  5M5W L;  1TWG L;  4Y7N L;  4A3G L;  3S15 L;  1TWH L;  2E2J L;  3K7A L;  5M5X L;  3S2H L;  3GTP L;  2NVT L;  4Y52 L;  2PMZ P;  2JA7 L;  3GTM L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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