2IE4C

Structure of the protein phosphatase 2a core enzyme bound to okadaic acid
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
pubmed doi rcsb
molecule tags Signaling protein,hydrolase
source organism Homo sapiens
molecule keywords Protein Phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 101
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-09-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2ie4C00
2A22A 4H2IA 4O24A 3RL3A 3QFNA 1Z2WA 1II7A 3H61A 1S8EA 2BCDA 1Z2XA 1OIEA 4ORAA 4F0ZA 3H63A 3H67A 3AUZA 2JOGA 3IB8A 2GJUA 5F3WA 1OI8A 2WDDA 4H2FA 1V73A 4H2GA 1S3NA 2BQ8X 4LACC 4I5LC 1XZWA 1T70A 3FGAC 5GTUA 3ZU0A 1HPUA 2IE3C 4MP0A 4UT3A 2QFRA 4JA9A 5INBA 3RQZA 1S3LA 4ZVZA 3RL4A 2HYPA 1S95A 3C5WC 3V4YA 1QFCA 4ORCA 2O8GA 4NZVA 3ZTVA 4UT2A 3H68A 4H2BA 2ZBMA 2Z72A 3H64A 4KBPA 1M63A 1UTEA 1QHWA 5IOHA 4TUIA 4MOVA 4KKZA 5HPEA 1MF8A 1S70A 2NYLC 3K7WC 3IB7A 2YVTA 3C9FA 4IL1A 3QFMA 3QFOA 4LTYA 1XM7A 1IT6A 2DFJA 3GVEA 2WDFA 2Q8UA 3PSOA 2WDEA 1S3MA 3QG5C 2WDCA 4FBWA 2BDXA 3H60A 3EGHA 2Z1AA 4FCXA 4FBKA 2IE4C 3H66A 3PSNA 3T1IA 3AV0A 1HO5A 1USHA 5C1VA 3KBPA 3HVQA 3LL8A 3THNA 3DW8C 4TUGA 3E7BA 5JPFA 1HP1A 2CV9A 4MOYA 5JPEA 1W24A 2IAEC 1OIDA 1T71A 4UWQA 4DSYA 3JYFA 3ICFA 3QFKA 4LU9A 4ORBA 4XPNA 2Z06A 2NXFA 3DSCA 4OR9A 1U32A 5B8IA 5DNYA 3P71C 4UT3B 3CK2A 4O43A 4O5GA 1FJMA 4G9JA 4JA7A 2QFPA 4V0XA 4IYPC 4O4KA 3H69A 4B2OA 4DT2A 4ZX2A 2QJCA 1KBPA 4M0VA 1NNWA 4WWLA 2P6BA 4YKEA 1SU1A 1TCOA 2USHA 1AUIA 3K7VC 2XMOA 4I5NC 2O8AA 4H1SA 1G5BA 3THOB 4DHLA 3DSDA 5J28A 3IVDA 4Q7FA 4V0WA 1WARA 2HYOA 1JK7A 2NYMC 4FBQA 2AHDA 1UF3A 1WAO1 5JJTA 4V0VA 2NPPC 3EGGA 3IVEA 3H62B 2R17A 3N5UA 2KKNA 3RL5A 5EQVA 4J6OA 4H1YP 2HY1A 3E7AA 3TGHA 4HD0A
chains in the Genus database with same CATH superfamily
2A22A 4H2IA 4O24A 3RL3A 3QFNA 1Z2WA 1II7A 3H61A 1S8EA 2BCDA 1Z2XA 1OIEA 4ORAA 4F0ZA 2ZOAA 3H63A 3H67A 3AUZA 2JOGA 3IB8A 2GJUA 5F3WA 2DXNA 1OI8A 2WDDA 4H2FA 1V73A 4H2GA 1S3NA 2BQ8X 4LACC 4I5LC 1XZWA 1T70A 3FGAC 5GTUA 3ZU0A 1HPUA 2IE3C 4MP0A 4UT3A 2QFRA 4JA9A 5INBA 3RQZA 1S3LA 4ZVZA 3RL4A 2HYPA 1S95A 3C5WC 3V4YA 1QFCA 4ORCA 2O8GA 4NZVA 3ZTVA 4UT2A 3H68A 4H2BA 2ZBMA 2Z72A 3H64A 4KBPA 1M63A 1UTEA 1QHWA 5IOHA 4TUIA 4MOVA 4KKZA 5HPEA 1MF8A 1S70A 2NYLC 2ZO9B 3K7WC 3IB7A 2YVTA 3C9FA 4IL1A 3QFMA 3QFOA 4LTYA 1XM7A 1IT6A 2DFJA 3GVEA 2WDFA 2Q8UA 3PSOA 2WDEA 1S3MA 3QG5C 2WDCA 4FBWA 2BDXA 3H60A 3EGHA 2Z1AA 4FCXA 4FBKA 2IE4C 3H66A 3PSNA 3T1IA 3AV0A 1HO5A 1USHA 5C1VA 3KBPA 3HVQA 3LL8A 3THNA 3DW8C 4TUGA 3E7BA 5JPFA 1HP1A 2CV9A 4MOYA 5JPEA 1W24A 2IAEC 1OIDA 1T71A 4UWQA 4DSYA 3JYFA 3ICFA 3QFKA 2DXLA 4LU9A 4ORBA 4XPNA 2Z06A 2NXFA 3DSCA 3D03A 1U32A 4OR9A 5B8IA 5DNYA 3P71C 4UT3B 3CK2A 4O43A 4O5GA 1FJMA 4G9JA 4JA7A 2QFPA 4V0XA 4IYPC 4O4KA 3H69A 4B2OA 4DT2A 4ZX2A 2QJCA 1KBPA 4M0VA 1NNWA 4WWLA 2P6BA 4YKEA 1SU1A 1TCOA 2USHA 3FLOA 1AUIA 3K7VC 2XMOA 4I5NC 2O8AA 4H1SA 1G5BA 3THOB 4DHLA 3DSDA 5J28A 3IVDA 4Q7FA 4V0WA 1WARA 2HYOA 3E0JA 1JK7A 2NYMC 4FBQA 2YEQA 2AHDA 1UF3A 1WAO1 5JJTA 4V0VA 2NPPC 3EGGA 3IVEA 3H62B 2R17A 3N5UA 2KKNA 3RL5A 5EQVA 4J6OA 4H1YP 2HY1A 3E7AA 3TGHA 4HD0A
chains in the Genus database with same CATH topology
2A22A 4H2IA 4O24A 3RL3A 3QFNA 1Z2WA 1II7A 3H61A 1S8EA 2BCDA 1Z2XA 1OIEA 4ORAA 4F0ZA 2ZOAA 3H63A 3H67A 3AUZA 2JOGA 3IB8A 2GJUA 5F3WA 2DXNA 1OI8A 2WDDA 4H2FA 1V73A 4H2GA 1S3NA 2BQ8X 4LACC 4I5LC 1XZWA 1T70A 3FGAC 5GTUA 3ZU0A 1HPUA 2IE3C 4MP0A 4UT3A 2QFRA 4JA9A 5INBA 3RQZA 1S3LA 4ZVZA 3RL4A 2HYPA 1S95A 3C5WC 3V4YA 1QFCA 4ORCA 2O8GA 4NZVA 3ZTVA 4UT2A 3H68A 4H2BA 2ZBMA 2Z72A 3H64A 4KBPA 1M63A 1UTEA 1QHWA 5IOHA 4TUIA 4MOVA 4KKZA 5HPEA 1MF8A 1S70A 2NYLC 2ZO9B 3K7WC 3IB7A 2YVTA 3C9FA 4IL1A 3QFMA 3QFOA 4LTYA 1XM7A 1IT6A 2DFJA 3GVEA 2WDFA 2Q8UA 3PSOA 2WDEA 1S3MA 3QG5C 2WDCA 4FBWA 2BDXA 3H60A 3EGHA 2Z1AA 4FCXA 4FBKA 2IE4C 3H66A 3PSNA 3T1IA 3AV0A 1HO5A 1USHA 5C1VA 3KBPA 3HVQA 3LL8A 3THNA 3DW8C 4TUGA 3E7BA 5JPFA 1HP1A 2CV9A 4MOYA 5JPEA 1W24A 2IAEC 1OIDA 1T71A 4UWQA 4DSYA 3JYFA 3ICFA 3QFKA 2DXLA 4LU9A 4ORBA 4XPNA 2Z06A 2NXFA 3DSCA 3D03A 1U32A 4OR9A 5B8IA 5DNYA 3P71C 4UT3B 3CK2A 4O43A 4O5GA 1FJMA 4G9JA 4JA7A 2QFPA 4V0XA 4IYPC 4O4KA 3H69A 4B2OA 4DT2A 4ZX2A 2QJCA 1KBPA 4M0VA 1NNWA 4WWLA 2P6BA 4YKEA 1SU1A 1TCOA 2USHA 3FLOA 1AUIA 3K7VC 2XMOA 4I5NC 2O8AA 4H1SA 1G5BA 3THOB 4DHLA 3DSDA 5J28A 3IVDA 4Q7FA 4V0WA 1WARA 2HYOA 3E0JA 1JK7A 2NYMC 4FBQA 2YEQA 2AHDA 1UF3A 1WAO1 5JJTA 4V0VA 2NPPC 3EGGA 3IVEA 3H62B 2R17A 3N5UA 2KKNA 3RL5A 5EQVA 4J6OA 4H1YP 2HY1A 3E7AA 3TGHA 4HD0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A22 A;  4H2I A;  4O24 A;  3RL3 A;  3QFN A;  1Z2W A;  1II7 A;  3H61 A;  1S8E A;  2BCD A;  1Z2X A;  1OIE A;  4ORA A;  4F0Z A;  3H63 A;  3H67 A;  3AUZ A;  2JOG A;  3IB8 A;  2GJU A;  5F3W A;  1OI8 A;  2WDD A;  4H2F A;  1V73 A;  4H2G A;  1S3N A;  2BQ8 X;  4LAC C;  4I5L C;  1XZW A;  1T70 A;  3FGA C;  5GTU A;  3ZU0 A;  1HPU A;  2IE3 C;  4MP0 A;  4UT3 A;  2QFR A;  4JA9 A;  5INB A;  3RQZ A;  1S3L A;  4ZVZ A;  3RL4 A;  2HYP A;  1S95 A;  3C5W C;  3V4Y A;  1QFC A;  4ORC A;  2O8G A;  4NZV A;  3ZTV A;  4UT2 A;  3H68 A;  4H2B A;  2ZBM A;  2Z72 A;  3H64 A;  4KBP A;  1M63 A;  1UTE A;  1QHW A;  5IOH A;  4TUI A;  4MOV A;  4KKZ A;  5HPE A;  1MF8 A;  1S70 A;  2NYL C;  3K7W C;  3IB7 A;  2YVT A;  3C9F A;  4IL1 A;  3QFM A;  3QFO A;  4LTY A;  1XM7 A;  1IT6 A;  2DFJ A;  3GVE A;  2WDF A;  2Q8U A;  3PSO A;  2WDE A;  1S3M A;  3QG5 C;  2WDC A;  4FBW A;  2BDX A;  3H60 A;  3EGH A;  2Z1A A;  4FCX A;  4FBK A;  2IE4 C;  3H66 A;  3PSN A;  3T1I A;  3AV0 A;  1HO5 A;  1USH A;  5C1V A;  3KBP A;  3HVQ A;  3LL8 A;  3THN A;  3DW8 C;  4TUG A;  3E7B A;  5JPF A;  1HP1 A;  2CV9 A;  4MOY A;  5JPE A;  1W24 A;  2IAE C;  1OID A;  1T71 A;  4UWQ A;  4DSY A;  3JYF A;  3ICF A;  3QFK A;  4LU9 A;  4ORB A;  4XPN A;  2Z06 A;  2NXF A;  3DSC A;  4OR9 A;  1U32 A;  5B8I A;  5DNY A;  3P71 C;  4UT3 B;  3CK2 A;  4O43 A;  4O5G A;  1FJM A;  4G9J A;  4JA7 A;  2QFP A;  4V0X A;  4IYP C;  4O4K A;  3H69 A;  4B2O A;  4DT2 A;  4ZX2 A;  2QJC A;  1KBP A;  4M0V A;  1NNW A;  4WWL A;  2P6B A;  4YKE A;  1SU1 A;  1TCO A;  2USH A;  1AUI A;  3K7V C;  2XMO A;  4I5N C;  2O8A A;  4H1S A;  1G5B A;  3THO B;  4DHL A;  3DSD A;  5J28 A;  3IVD A;  4Q7F A;  4V0W A;  1WAR A;  2HYO A;  1JK7 A;  2NYM C;  4FBQ A;  2AHD A;  1UF3 A;  1WAO 1;  5JJT A;  4V0V A;  2NPP C;  3EGG A;  3IVE A;  3H62 B;  2R17 A;  3N5U A;  2KKN A;  3RL5 A;  5EQV A;  4J6O A;  4H1Y P;  2HY1 A;  3E7A A;  3TGH A;  4HD0 A; 
#chains in the Genus database with same CATH topology
 2A22 A;  4H2I A;  4O24 A;  3RL3 A;  3QFN A;  1Z2W A;  1II7 A;  3H61 A;  1S8E A;  2BCD A;  1Z2X A;  1OIE A;  4ORA A;  4F0Z A;  2ZOA A;  3H63 A;  3H67 A;  3AUZ A;  2JOG A;  3IB8 A;  2GJU A;  5F3W A;  2DXN A;  1OI8 A;  2WDD A;  4H2F A;  1V73 A;  4H2G A;  1S3N A;  2BQ8 X;  4LAC C;  4I5L C;  1XZW A;  1T70 A;  3FGA C;  5GTU A;  3ZU0 A;  1HPU A;  2IE3 C;  4MP0 A;  4UT3 A;  2QFR A;  4JA9 A;  5INB A;  3RQZ A;  1S3L A;  4ZVZ A;  3RL4 A;  2HYP A;  1S95 A;  3C5W C;  3V4Y A;  1QFC A;  4ORC A;  2O8G A;  4NZV A;  3ZTV A;  4UT2 A;  3H68 A;  4H2B A;  2ZBM A;  2Z72 A;  3H64 A;  4KBP A;  1M63 A;  1UTE A;  1QHW A;  5IOH A;  4TUI A;  4MOV A;  4KKZ A;  5HPE A;  1MF8 A;  1S70 A;  2NYL C;  2ZO9 B;  3K7W C;  3IB7 A;  2YVT A;  3C9F A;  4IL1 A;  3QFM A;  3QFO A;  4LTY A;  1XM7 A;  1IT6 A;  2DFJ A;  3GVE A;  2WDF A;  2Q8U A;  3PSO A;  2WDE A;  1S3M A;  3QG5 C;  2WDC A;  4FBW A;  2BDX A;  3H60 A;  3EGH A;  2Z1A A;  4FCX A;  4FBK A;  2IE4 C;  3H66 A;  3PSN A;  3T1I A;  3AV0 A;  1HO5 A;  1USH A;  5C1V A;  3KBP A;  3HVQ A;  3LL8 A;  3THN A;  3DW8 C;  4TUG A;  3E7B A;  5JPF A;  1HP1 A;  2CV9 A;  4MOY A;  5JPE A;  1W24 A;  2IAE C;  1OID A;  1T71 A;  4UWQ A;  4DSY A;  3JYF A;  3ICF A;  3QFK A;  2DXL A;  4LU9 A;  4ORB A;  4XPN A;  2Z06 A;  2NXF A;  3DSC A;  3D03 A;  1U32 A;  4OR9 A;  5B8I A;  5DNY A;  3P71 C;  4UT3 B;  3CK2 A;  4O43 A;  4O5G A;  1FJM A;  4G9J A;  4JA7 A;  2QFP A;  4V0X A;  4IYP C;  4O4K A;  3H69 A;  4B2O A;  4DT2 A;  4ZX2 A;  2QJC A;  1KBP A;  4M0V A;  1NNW A;  4WWL A;  2P6B A;  4YKE A;  1SU1 A;  1TCO A;  2USH A;  3FLO A;  1AUI A;  3K7V C;  2XMO A;  4I5N C;  2O8A A;  4H1S A;  1G5B A;  3THO B;  4DHL A;  3DSD A;  5J28 A;  3IVD A;  4Q7F A;  4V0W A;  1WAR A;  2HYO A;  3E0J A;  1JK7 A;  2NYM C;  4FBQ A;  2YEQ A;  2AHD A;  1UF3 A;  1WAO 1;  5JJT A;  4V0V A;  2NPP C;  3EGG A;  3IVE A;  3H62 B;  2R17 A;  3N5U A;  2KKN A;  3RL5 A;  5EQV A;  4J6O A;  4H1Y P;  2HY1 A;  3E7A A;  3TGH A;  4HD0 A; 
#chains in the Genus database with same CATH homology
 2A22 A;  4H2I A;  4O24 A;  3RL3 A;  3QFN A;  1Z2W A;  1II7 A;  3H61 A;  1S8E A;  2BCD A;  1Z2X A;  1OIE A;  4ORA A;  4F0Z A;  2ZOA A;  3H63 A;  3H67 A;  3AUZ A;  2JOG A;  3IB8 A;  2GJU A;  5F3W A;  2DXN A;  1OI8 A;  2WDD A;  4H2F A;  1V73 A;  4H2G A;  1S3N A;  2BQ8 X;  4LAC C;  4I5L C;  1XZW A;  1T70 A;  3FGA C;  5GTU A;  3ZU0 A;  1HPU A;  2IE3 C;  4MP0 A;  4UT3 A;  2QFR A;  4JA9 A;  5INB A;  3RQZ A;  1S3L A;  4ZVZ A;  3RL4 A;  2HYP A;  1S95 A;  3C5W C;  3V4Y A;  1QFC A;  4ORC A;  2O8G A;  4NZV A;  3ZTV A;  4UT2 A;  3H68 A;  4H2B A;  2ZBM A;  2Z72 A;  3H64 A;  4KBP A;  1M63 A;  1UTE A;  1QHW A;  5IOH A;  4TUI A;  4MOV A;  4KKZ A;  5HPE A;  1MF8 A;  1S70 A;  2NYL C;  2ZO9 B;  3K7W C;  3IB7 A;  2YVT A;  3C9F A;  4IL1 A;  3QFM A;  3QFO A;  4LTY A;  1XM7 A;  1IT6 A;  2DFJ A;  3GVE A;  2WDF A;  2Q8U A;  3PSO A;  2WDE A;  1S3M A;  3QG5 C;  2WDC A;  4FBW A;  2BDX A;  3H60 A;  3EGH A;  2Z1A A;  4FCX A;  4FBK A;  2IE4 C;  3H66 A;  3PSN A;  3T1I A;  3AV0 A;  1HO5 A;  1USH A;  5C1V A;  3KBP A;  3HVQ A;  3LL8 A;  3THN A;  3DW8 C;  4TUG A;  3E7B A;  5JPF A;  1HP1 A;  2CV9 A;  4MOY A;  5JPE A;  1W24 A;  2IAE C;  1OID A;  1T71 A;  4UWQ A;  4DSY A;  3JYF A;  3ICF A;  3QFK A;  2DXL A;  4LU9 A;  4ORB A;  4XPN A;  2Z06 A;  2NXF A;  3DSC A;  3D03 A;  1U32 A;  4OR9 A;  5B8I A;  5DNY A;  3P71 C;  4UT3 B;  3CK2 A;  4O43 A;  4O5G A;  1FJM A;  4G9J A;  4JA7 A;  2QFP A;  4V0X A;  4IYP C;  4O4K A;  3H69 A;  4B2O A;  4DT2 A;  4ZX2 A;  2QJC A;  1KBP A;  4M0V A;  1NNW A;  4WWL A;  2P6B A;  4YKE A;  1SU1 A;  1TCO A;  2USH A;  3FLO A;  1AUI A;  3K7V C;  2XMO A;  4I5N C;  2O8A A;  4H1S A;  1G5B A;  3THO B;  4DHL A;  3DSD A;  5J28 A;  3IVD A;  4Q7F A;  4V0W A;  1WAR A;  2HYO A;  3E0J A;  1JK7 A;  2NYM C;  4FBQ A;  2YEQ A;  2AHD A;  1UF3 A;  1WAO 1;  5JJT A;  4V0V A;  2NPP C;  3EGG A;  3IVE A;  3H62 B;  2R17 A;  3N5U A;  2KKN A;  3RL5 A;  5EQV A;  4J6O A;  4H1Y P;  2HY1 A;  3E7A A;  3TGH A;  4HD0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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