2NPPC

Structure of the protein phosphatase 2a holoenzyme
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
308
structure length
308
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the protein phosphatase 2A holoenzyme
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein Phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 102
structure length 308
sequence length 308
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nppC00
2NYMC 5C1VA 2WDFA 5GTUA 3KBPA 3H61A 4LTYA 3T1IA 3HVQA 2NXFA 4LU9A 4M0VA 3IVDA 2Z1AA 4YKEA 4V0VA 3QFKA 4JA7A 2IE3C 2XMOA 4O43A 3PSNA 5EQVA 1USHA 2BDXA 2QFPA 4DHLA 4DT2A 4J6OA 2QFRA 3DSDA 4H2GA 4XPNA 5DNYA 1HP1A 2JOGA 4F0ZA 1II7A 2HYOA 3RL5A 4I5NC 3QG5C 1TCOA 4UWQA 3E7BA 2R17A 4FBWA 3THOB 4H2FA 1T70A 3N5UA 2Z72A 1MF8A 1XM7A 4KBPA 2WDEA 4LACC 2GJUA 1JK7A 3C9FA 1T71A 2A22A 1AUIA 2NYLC 4O4KA 3EGGA 2P6BA 3TGHA 3ICFA 4ORBA 1SU1A 1U32A 5B8IA 5F3WA 1M63A 1G5BA 5HPEA 1S70A 5JPEA 4UT3B 4B2OA 3P71C 1S8EA 4O24A 4FBKA 2WDDA 3K7WC 4O5GA 4V0XA 3H63A 4ORCA 3DSCA 4ZX2A 4ZVZA 4G9JA 3QFNA 4IL1A 2DFJA 3H66A 1NNWA 1XZWA 3EGHA 3IVEA 1OI8A 2WDCA 1KBPA 1S3MA 4H2IA 4IYPC 1HO5A 5J28A 2YVTA 4H1SA 3H69A 1Z2XA 2BCDA 5JJTA 1V73A 4KKZA 3AUZA 3IB8A 1S95A 4TUGA 1S3LA 2O8GA 3H64A 3H60A 1W24A 4DSYA 4Q7FA 1Z2WA 2KKNA 2USHA 2Z06A 2IE4C 3ZTVA 3K7VC 1UF3A 1HPUA 4MP0A 3E7AA 3ZU0A 4UT3A 3QFOA 3H68A 1OIDA 2IAEC 3H67A 1WARA 4HD0A 2HY1A 1OIEA 2ZBMA 3RQZA 2Q8UA 2O8AA 4MOVA 4FCXA 4H2BA 3RL4A 3THNA 3DW8C 3H62B 1FJMA 4I5LC 4UT2A 4OR9A 4TUIA 3AV0A 4H1YP 4ORAA 3QFMA 3CK2A 3LL8A 2NPPC 2QJCA 3C5WC 4MOYA 1WAO1 4JA9A 1S3NA 3GVEA 4WWLA 5JPFA 2HYPA 4NZVA 2BQ8X 3IB7A 1QFCA 5IOHA 3V4YA 3RL3A 1QHWA 1UTEA 5INBA 4FBQA 1IT6A 3PSOA 3JYFA 2AHDA 4V0WA 3FGAC 2CV9A
chains in the Genus database with same CATH superfamily
2NYMC 5C1VA 2WDFA 5GTUA 3KBPA 3H61A 4LTYA 3T1IA 3HVQA 2NXFA 4LU9A 4M0VA 3IVDA 2Z1AA 4YKEA 4V0VA 3QFKA 4JA7A 2IE3C 2XMOA 4O43A 3PSNA 5EQVA 2ZOAA 1USHA 2BDXA 2QFPA 4DHLA 3D03A 4J6OA 4DT2A 2QFRA 3DSDA 4H2GA 4XPNA 5DNYA 1HP1A 2JOGA 4F0ZA 1II7A 2HYOA 3RL5A 4I5NC 3QG5C 1TCOA 4UWQA 3E7BA 2R17A 4FBWA 3THOB 4H2FA 1T70A 3N5UA 2Z72A 1MF8A 1XM7A 4KBPA 2WDEA 4LACC 2GJUA 1JK7A 3C9FA 1T71A 2A22A 1AUIA 2NYLC 4O4KA 3EGGA 2P6BA 3TGHA 3ICFA 4ORBA 1SU1A 1U32A 5B8IA 5F3WA 1M63A 1G5BA 5HPEA 1S70A 5JPEA 4UT3B 4B2OA 3P71C 1S8EA 4O24A 4FBKA 2WDDA 3K7WC 4O5GA 4V0XA 3H63A 4ORCA 3DSCA 4ZX2A 4ZVZA 4G9JA 3QFNA 4IL1A 2DFJA 2DXNA 3H66A 1NNWA 1XZWA 3EGHA 3IVEA 1OI8A 2WDCA 1KBPA 1S3MA 4H2IA 4IYPC 1HO5A 5J28A 2YVTA 4H1SA 3H69A 1Z2XA 2BCDA 2YEQA 5JJTA 1V73A 4KKZA 3AUZA 3IB8A 1S95A 3FLOA 4TUGA 1S3LA 2O8GA 3H64A 3H60A 1W24A 4DSYA 4Q7FA 1Z2WA 2KKNA 2USHA 2Z06A 2IE4C 3ZTVA 3K7VC 1UF3A 1HPUA 4MP0A 3E7AA 3ZU0A 4UT3A 3QFOA 3H68A 1OIDA 2IAEC 3H67A 1WARA 4HD0A 2HY1A 1OIEA 2ZBMA 3RQZA 2Q8UA 2O8AA 4MOVA 4FCXA 4H2BA 3RL4A 3THNA 3DW8C 3H62B 1FJMA 3E0JA 4I5LC 4UT2A 4OR9A 4TUIA 3AV0A 4H1YP 4ORAA 3QFMA 2DXLA 3CK2A 3LL8A 2NPPC 2QJCA 3C5WC 4MOYA 2ZO9B 1WAO1 4JA9A 1S3NA 3GVEA 4WWLA 5JPFA 2HYPA 4NZVA 2BQ8X 3IB7A 1QFCA 5IOHA 3V4YA 3RL3A 1QHWA 1UTEA 5INBA 4FBQA 1IT6A 3PSOA 3JYFA 2AHDA 4V0WA 3FGAC 2CV9A
chains in the Genus database with same CATH topology
2NYMC 5C1VA 2WDFA 5GTUA 3KBPA 3H61A 4LTYA 3T1IA 3HVQA 2NXFA 4LU9A 4M0VA 3IVDA 2Z1AA 4YKEA 4V0VA 3QFKA 4JA7A 2IE3C 2XMOA 4O43A 3PSNA 5EQVA 2ZOAA 1USHA 2BDXA 2QFPA 4DHLA 3D03A 4J6OA 4DT2A 2QFRA 3DSDA 4H2GA 4XPNA 5DNYA 1HP1A 2JOGA 4F0ZA 1II7A 2HYOA 3RL5A 4I5NC 3QG5C 1TCOA 4UWQA 3E7BA 2R17A 4FBWA 3THOB 4H2FA 1T70A 3N5UA 2Z72A 1MF8A 1XM7A 4KBPA 2WDEA 4LACC 2GJUA 1JK7A 3C9FA 1T71A 2A22A 1AUIA 2NYLC 4O4KA 3EGGA 2P6BA 3TGHA 3ICFA 4ORBA 1SU1A 1U32A 5B8IA 5F3WA 1M63A 1G5BA 5HPEA 1S70A 5JPEA 4UT3B 4B2OA 3P71C 1S8EA 4O24A 4FBKA 2WDDA 3K7WC 4O5GA 4V0XA 3H63A 4ORCA 3DSCA 4ZX2A 4ZVZA 4G9JA 3QFNA 4IL1A 2DFJA 2DXNA 3H66A 1NNWA 1XZWA 3EGHA 3IVEA 1OI8A 2WDCA 1KBPA 1S3MA 4H2IA 4IYPC 1HO5A 5J28A 2YVTA 4H1SA 3H69A 1Z2XA 2BCDA 2YEQA 5JJTA 1V73A 4KKZA 3AUZA 3IB8A 1S95A 3FLOA 4TUGA 1S3LA 2O8GA 3H64A 3H60A 1W24A 4DSYA 4Q7FA 1Z2WA 2KKNA 2USHA 2Z06A 2IE4C 3ZTVA 3K7VC 1UF3A 1HPUA 4MP0A 3E7AA 3ZU0A 4UT3A 3QFOA 3H68A 1OIDA 2IAEC 3H67A 1WARA 4HD0A 2HY1A 1OIEA 2ZBMA 3RQZA 2Q8UA 2O8AA 4MOVA 4FCXA 4H2BA 3RL4A 3THNA 3DW8C 3H62B 1FJMA 3E0JA 4I5LC 4UT2A 4OR9A 4TUIA 3AV0A 4H1YP 4ORAA 3QFMA 2DXLA 3CK2A 3LL8A 2NPPC 2QJCA 3C5WC 4MOYA 2ZO9B 1WAO1 4JA9A 1S3NA 3GVEA 4WWLA 5JPFA 2HYPA 4NZVA 2BQ8X 3IB7A 1QFCA 5IOHA 3V4YA 3RL3A 1QHWA 1UTEA 5INBA 4FBQA 1IT6A 3PSOA 3JYFA 2AHDA 4V0WA 3FGAC 2CV9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYM C;  5C1V A;  2WDF A;  5GTU A;  3KBP A;  3H61 A;  4LTY A;  3T1I A;  3HVQ A;  2NXF A;  4LU9 A;  4M0V A;  3IVD A;  2Z1A A;  4YKE A;  4V0V A;  3QFK A;  4JA7 A;  2IE3 C;  2XMO A;  4O43 A;  3PSN A;  5EQV A;  1USH A;  2BDX A;  2QFP A;  4DHL A;  4DT2 A;  4J6O A;  2QFR A;  3DSD A;  4H2G A;  4XPN A;  5DNY A;  1HP1 A;  2JOG A;  4F0Z A;  1II7 A;  2HYO A;  3RL5 A;  4I5N C;  3QG5 C;  1TCO A;  4UWQ A;  3E7B A;  2R17 A;  4FBW A;  3THO B;  4H2F A;  1T70 A;  3N5U A;  2Z72 A;  1MF8 A;  1XM7 A;  4KBP A;  2WDE A;  4LAC C;  2GJU A;  1JK7 A;  3C9F A;  1T71 A;  2A22 A;  1AUI A;  2NYL C;  4O4K A;  3EGG A;  2P6B A;  3TGH A;  3ICF A;  4ORB A;  1SU1 A;  1U32 A;  5B8I A;  5F3W A;  1M63 A;  1G5B A;  5HPE A;  1S70 A;  5JPE A;  4UT3 B;  4B2O A;  3P71 C;  1S8E A;  4O24 A;  4FBK A;  2WDD A;  3K7W C;  4O5G A;  4V0X A;  3H63 A;  4ORC A;  3DSC A;  4ZX2 A;  4ZVZ A;  4G9J A;  3QFN A;  4IL1 A;  2DFJ A;  3H66 A;  1NNW A;  1XZW A;  3EGH A;  3IVE A;  1OI8 A;  2WDC A;  1KBP A;  1S3M A;  4H2I A;  4IYP C;  1HO5 A;  5J28 A;  2YVT A;  4H1S A;  3H69 A;  1Z2X A;  2BCD A;  5JJT A;  1V73 A;  4KKZ A;  3AUZ A;  3IB8 A;  1S95 A;  4TUG A;  1S3L A;  2O8G A;  3H64 A;  3H60 A;  1W24 A;  4DSY A;  4Q7F A;  1Z2W A;  2KKN A;  2USH A;  2Z06 A;  2IE4 C;  3ZTV A;  3K7V C;  1UF3 A;  1HPU A;  4MP0 A;  3E7A A;  3ZU0 A;  4UT3 A;  3QFO A;  3H68 A;  1OID A;  2IAE C;  3H67 A;  1WAR A;  4HD0 A;  2HY1 A;  1OIE A;  2ZBM A;  3RQZ A;  2Q8U A;  2O8A A;  4MOV A;  4FCX A;  4H2B A;  3RL4 A;  3THN A;  3DW8 C;  3H62 B;  1FJM A;  4I5L C;  4UT2 A;  4OR9 A;  4TUI A;  3AV0 A;  4H1Y P;  4ORA A;  3QFM A;  3CK2 A;  3LL8 A;  2NPP C;  2QJC A;  3C5W C;  4MOY A;  1WAO 1;  4JA9 A;  1S3N A;  3GVE A;  4WWL A;  5JPF A;  2HYP A;  4NZV A;  2BQ8 X;  3IB7 A;  1QFC A;  5IOH A;  3V4Y A;  3RL3 A;  1QHW A;  1UTE A;  5INB A;  4FBQ A;  1IT6 A;  3PSO A;  3JYF A;  2AHD A;  4V0W A;  3FGA C;  2CV9 A; 
#chains in the Genus database with same CATH topology
 2NYM C;  5C1V A;  2WDF A;  5GTU A;  3KBP A;  3H61 A;  4LTY A;  3T1I A;  3HVQ A;  2NXF A;  4LU9 A;  4M0V A;  3IVD A;  2Z1A A;  4YKE A;  4V0V A;  3QFK A;  4JA7 A;  2IE3 C;  2XMO A;  4O43 A;  3PSN A;  5EQV A;  2ZOA A;  1USH A;  2BDX A;  2QFP A;  4DHL A;  3D03 A;  4J6O A;  4DT2 A;  2QFR A;  3DSD A;  4H2G A;  4XPN A;  5DNY A;  1HP1 A;  2JOG A;  4F0Z A;  1II7 A;  2HYO A;  3RL5 A;  4I5N C;  3QG5 C;  1TCO A;  4UWQ A;  3E7B A;  2R17 A;  4FBW A;  3THO B;  4H2F A;  1T70 A;  3N5U A;  2Z72 A;  1MF8 A;  1XM7 A;  4KBP A;  2WDE A;  4LAC C;  2GJU A;  1JK7 A;  3C9F A;  1T71 A;  2A22 A;  1AUI A;  2NYL C;  4O4K A;  3EGG A;  2P6B A;  3TGH A;  3ICF A;  4ORB A;  1SU1 A;  1U32 A;  5B8I A;  5F3W A;  1M63 A;  1G5B A;  5HPE A;  1S70 A;  5JPE A;  4UT3 B;  4B2O A;  3P71 C;  1S8E A;  4O24 A;  4FBK A;  2WDD A;  3K7W C;  4O5G A;  4V0X A;  3H63 A;  4ORC A;  3DSC A;  4ZX2 A;  4ZVZ A;  4G9J A;  3QFN A;  4IL1 A;  2DFJ A;  2DXN A;  3H66 A;  1NNW A;  1XZW A;  3EGH A;  3IVE A;  1OI8 A;  2WDC A;  1KBP A;  1S3M A;  4H2I A;  4IYP C;  1HO5 A;  5J28 A;  2YVT A;  4H1S A;  3H69 A;  1Z2X A;  2BCD A;  2YEQ A;  5JJT A;  1V73 A;  4KKZ A;  3AUZ A;  3IB8 A;  1S95 A;  3FLO A;  4TUG A;  1S3L A;  2O8G A;  3H64 A;  3H60 A;  1W24 A;  4DSY A;  4Q7F A;  1Z2W A;  2KKN A;  2USH A;  2Z06 A;  2IE4 C;  3ZTV A;  3K7V C;  1UF3 A;  1HPU A;  4MP0 A;  3E7A A;  3ZU0 A;  4UT3 A;  3QFO A;  3H68 A;  1OID A;  2IAE C;  3H67 A;  1WAR A;  4HD0 A;  2HY1 A;  1OIE A;  2ZBM A;  3RQZ A;  2Q8U A;  2O8A A;  4MOV A;  4FCX A;  4H2B A;  3RL4 A;  3THN A;  3DW8 C;  3H62 B;  1FJM A;  3E0J A;  4I5L C;  4UT2 A;  4OR9 A;  4TUI A;  3AV0 A;  4H1Y P;  4ORA A;  3QFM A;  2DXL A;  3CK2 A;  3LL8 A;  2NPP C;  2QJC A;  3C5W C;  4MOY A;  2ZO9 B;  1WAO 1;  4JA9 A;  1S3N A;  3GVE A;  4WWL A;  5JPF A;  2HYP A;  4NZV A;  2BQ8 X;  3IB7 A;  1QFC A;  5IOH A;  3V4Y A;  3RL3 A;  1QHW A;  1UTE A;  5INB A;  4FBQ A;  1IT6 A;  3PSO A;  3JYF A;  2AHD A;  4V0W A;  3FGA C;  2CV9 A; 
#chains in the Genus database with same CATH homology
 2NYM C;  5C1V A;  2WDF A;  5GTU A;  3KBP A;  3H61 A;  4LTY A;  3T1I A;  3HVQ A;  2NXF A;  4LU9 A;  4M0V A;  3IVD A;  2Z1A A;  4YKE A;  4V0V A;  3QFK A;  4JA7 A;  2IE3 C;  2XMO A;  4O43 A;  3PSN A;  5EQV A;  2ZOA A;  1USH A;  2BDX A;  2QFP A;  4DHL A;  3D03 A;  4J6O A;  4DT2 A;  2QFR A;  3DSD A;  4H2G A;  4XPN A;  5DNY A;  1HP1 A;  2JOG A;  4F0Z A;  1II7 A;  2HYO A;  3RL5 A;  4I5N C;  3QG5 C;  1TCO A;  4UWQ A;  3E7B A;  2R17 A;  4FBW A;  3THO B;  4H2F A;  1T70 A;  3N5U A;  2Z72 A;  1MF8 A;  1XM7 A;  4KBP A;  2WDE A;  4LAC C;  2GJU A;  1JK7 A;  3C9F A;  1T71 A;  2A22 A;  1AUI A;  2NYL C;  4O4K A;  3EGG A;  2P6B A;  3TGH A;  3ICF A;  4ORB A;  1SU1 A;  1U32 A;  5B8I A;  5F3W A;  1M63 A;  1G5B A;  5HPE A;  1S70 A;  5JPE A;  4UT3 B;  4B2O A;  3P71 C;  1S8E A;  4O24 A;  4FBK A;  2WDD A;  3K7W C;  4O5G A;  4V0X A;  3H63 A;  4ORC A;  3DSC A;  4ZX2 A;  4ZVZ A;  4G9J A;  3QFN A;  4IL1 A;  2DFJ A;  2DXN A;  3H66 A;  1NNW A;  1XZW A;  3EGH A;  3IVE A;  1OI8 A;  2WDC A;  1KBP A;  1S3M A;  4H2I A;  4IYP C;  1HO5 A;  5J28 A;  2YVT A;  4H1S A;  3H69 A;  1Z2X A;  2BCD A;  2YEQ A;  5JJT A;  1V73 A;  4KKZ A;  3AUZ A;  3IB8 A;  1S95 A;  3FLO A;  4TUG A;  1S3L A;  2O8G A;  3H64 A;  3H60 A;  1W24 A;  4DSY A;  4Q7F A;  1Z2W A;  2KKN A;  2USH A;  2Z06 A;  2IE4 C;  3ZTV A;  3K7V C;  1UF3 A;  1HPU A;  4MP0 A;  3E7A A;  3ZU0 A;  4UT3 A;  3QFO A;  3H68 A;  1OID A;  2IAE C;  3H67 A;  1WAR A;  4HD0 A;  2HY1 A;  1OIE A;  2ZBM A;  3RQZ A;  2Q8U A;  2O8A A;  4MOV A;  4FCX A;  4H2B A;  3RL4 A;  3THN A;  3DW8 C;  3H62 B;  1FJM A;  3E0J A;  4I5L C;  4UT2 A;  4OR9 A;  4TUI A;  3AV0 A;  4H1Y P;  4ORA A;  3QFM A;  2DXL A;  3CK2 A;  3LL8 A;  2NPP C;  2QJC A;  3C5W C;  4MOY A;  2ZO9 B;  1WAO 1;  4JA9 A;  1S3N A;  3GVE A;  4WWL A;  5JPF A;  2HYP A;  4NZV A;  2BQ8 X;  3IB7 A;  1QFC A;  5IOH A;  3V4Y A;  3RL3 A;  1QHW A;  1UTE A;  5INB A;  4FBQ A;  1IT6 A;  3PSO A;  3JYF A;  2AHD A;  4V0W A;  3FGA C;  2CV9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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