2NYLC

Crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule keywords Protein phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 91
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nylC00
2QFPA 4FBKA 4ORAA 4WWLA 1UTEA 4XPNA 4UT3B 1Z2XA 3ZU0A 3DSDA 5DNYA 2QFRA 1G5BA 3EGHA 3C5WC 5J28A 1HPUA 4V0VA 2USHA 2GJUA 2YVTA 1KBPA 4Q7FA 3H69A 3H63A 2WDDA 4LACC 4H2GA 3E7AA 3LL8A 4J6OA 1OI8A 4G9JA 2A22A 3H64A 3RQZA 2DFJA 2P6BA 4MOVA 3V4YA 1XZWA 2Z06A 3QFMA 1S8EA 4FBQA 1T70A 3H60A 1WAO1 5F3WA 4ZVZA 1M63A 1QFCA 2CV9A 2NPPC 4LU9A 2QJCA 1USHA 5INBA 5JJTA 1II7A 1S3NA 1S3MA 3FGAC 3ICFA 4ZX2A 5HPEA 4DHLA 4HD0A 2HY1A 3THOB 3P71C 4TUGA 3N5UA 3QFKA 2IE4C 3C9FA 4V0XA 5B8IA 1UF3A 4JA7A 1TCOA 4JA9A 2NYMC 2R17A 3H68A 3K7VC 4YKEA 4UT3A 2ZBMA 3KBPA 4IL1A 2WDCA 4UWQA 3K7WC 4I5LC 3EGGA 2NXFA 4F0ZA 1FJMA 3JYFA 3H62B 1U32A 4ORBA 1OIEA 2O8AA 5IOHA 4ORCA 4OR9A 5JPFA 1W24A 4O43A 1AUIA 4V0WA 2XMOA 3TGHA 3PSOA 2WDFA 3PSNA 4M0VA 2BQ8X 2AHDA 2JOGA 3IB8A 3IVDA 4O4KA 4UT2A 1NNWA 5EQVA 4H2BA 3ZTVA 4KKZA 2Q8UA 5GTUA 1V73A 3H66A 2BDXA 3IB7A 4MOYA 4LTYA 3H67A 1QHWA 3DW8C 4O5GA 1Z2WA 2Z1AA 3HVQA 1HO5A 3GVEA 1S3LA 1JK7A 4FBWA 1T71A 1HP1A 2O8GA 3IVEA 3DSCA 4TUIA 2IE3C 3H61A 1SU1A 3QFNA 3T1IA 5JPEA 2WDEA 1OIDA 1XM7A 4IYPC 1MF8A 5C1VA 2NYLC 1S70A 2IAEC 4MP0A 3E7BA 3CK2A 4FCXA 1IT6A 3AUZA 1WARA 3QFOA 2HYOA 4I5NC 2HYPA 4DSYA 3AV0A 2Z72A 4NZVA 4O24A 4H1YP 2BCDA 3RL3A 4KBPA 4B2OA 4H1SA 4H2IA 3RL4A 3QG5C 3THNA 4H2FA 2KKNA 3RL5A 1S95A 4DT2A
chains in the Genus database with same CATH superfamily
2QFPA 4FBKA 4ORAA 4WWLA 1UTEA 4XPNA 3E0JA 4UT3B 1Z2XA 3ZU0A 3DSDA 5DNYA 2DXLA 2QFRA 1G5BA 3EGHA 3C5WC 5J28A 1HPUA 4V0VA 2USHA 2GJUA 2YVTA 1KBPA 4Q7FA 3H69A 3H63A 2WDDA 4LACC 4H2GA 3E7AA 3LL8A 4J6OA 1OI8A 4G9JA 2A22A 3H64A 3RQZA 2DFJA 2P6BA 4MOVA 3V4YA 1XZWA 2Z06A 3QFMA 1S8EA 4FBQA 1T70A 3H60A 1WAO1 5F3WA 4ZVZA 1M63A 1QFCA 2CV9A 2NPPC 4LU9A 2QJCA 1USHA 5INBA 5JJTA 1II7A 1S3NA 1S3MA 3FGAC 3ICFA 3FLOA 4ZX2A 5HPEA 4DHLA 4HD0A 2HY1A 3THOB 3P71C 4TUGA 3N5UA 3QFKA 2IE4C 3C9FA 4V0XA 5B8IA 1UF3A 4JA7A 1TCOA 4JA9A 2NYMC 2R17A 3H68A 3K7VC 4YKEA 4UT3A 2ZBMA 3KBPA 4IL1A 2WDCA 4UWQA 3K7WC 4I5LC 3EGGA 2NXFA 4F0ZA 1FJMA 3JYFA 3H62B 1U32A 4ORBA 1OIEA 2O8AA 5IOHA 4ORCA 4OR9A 5JPFA 1W24A 4O43A 2DXNA 1AUIA 4V0WA 2XMOA 3TGHA 3PSOA 2WDFA 3D03A 3PSNA 4M0VA 2BQ8X 2AHDA 2JOGA 2YEQA 3IB8A 3IVDA 4O4KA 4UT2A 1NNWA 5EQVA 4H2BA 3ZTVA 4KKZA 2Q8UA 5GTUA 2ZOAA 1V73A 3H66A 2BDXA 3IB7A 4MOYA 4LTYA 3H67A 1QHWA 3DW8C 4O5GA 1Z2WA 2Z1AA 3HVQA 1HO5A 3GVEA 1S3LA 1JK7A 4FBWA 1T71A 1HP1A 2O8GA 3IVEA 3DSCA 4TUIA 2IE3C 3H61A 1SU1A 3QFNA 3T1IA 5JPEA 2WDEA 1OIDA 1XM7A 4IYPC 1MF8A 5C1VA 2NYLC 1S70A 2IAEC 4MP0A 3E7BA 3CK2A 4FCXA 1IT6A 3AUZA 1WARA 3QFOA 2HYOA 4I5NC 2HYPA 4DSYA 3AV0A 2Z72A 4NZVA 4O24A 4H1YP 2BCDA 3RL3A 4KBPA 4B2OA 4H1SA 4H2IA 3RL4A 3QG5C 3THNA 4H2FA 2KKNA 3RL5A 1S95A 4DT2A 2ZO9B
chains in the Genus database with same CATH topology
2QFPA 4FBKA 4ORAA 4WWLA 1UTEA 4XPNA 3E0JA 4UT3B 1Z2XA 3ZU0A 3DSDA 5DNYA 2DXLA 2QFRA 1G5BA 3EGHA 3C5WC 5J28A 1HPUA 4V0VA 2USHA 2GJUA 2YVTA 1KBPA 4Q7FA 3H69A 3H63A 2WDDA 4LACC 4H2GA 3E7AA 3LL8A 4J6OA 1OI8A 4G9JA 2A22A 3H64A 3RQZA 2DFJA 2P6BA 4MOVA 3V4YA 1XZWA 2Z06A 3QFMA 1S8EA 4FBQA 1T70A 3H60A 1WAO1 5F3WA 4ZVZA 1M63A 1QFCA 2CV9A 2NPPC 4LU9A 2QJCA 1USHA 5INBA 5JJTA 1II7A 1S3NA 1S3MA 3FGAC 3ICFA 3FLOA 4ZX2A 5HPEA 4DHLA 4HD0A 2HY1A 3THOB 3P71C 4TUGA 3N5UA 3QFKA 2IE4C 3C9FA 4V0XA 5B8IA 1UF3A 4JA7A 1TCOA 4JA9A 2NYMC 2R17A 3H68A 3K7VC 4YKEA 4UT3A 2ZBMA 3KBPA 4IL1A 2WDCA 4UWQA 3K7WC 4I5LC 3EGGA 2NXFA 4F0ZA 1FJMA 3JYFA 3H62B 1U32A 4ORBA 1OIEA 2O8AA 5IOHA 4ORCA 4OR9A 5JPFA 1W24A 4O43A 2DXNA 1AUIA 4V0WA 2XMOA 3TGHA 3PSOA 2WDFA 3D03A 3PSNA 4M0VA 2BQ8X 2AHDA 2JOGA 2YEQA 3IB8A 3IVDA 4O4KA 4UT2A 1NNWA 5EQVA 4H2BA 3ZTVA 4KKZA 2Q8UA 5GTUA 2ZOAA 1V73A 3H66A 2BDXA 3IB7A 4MOYA 4LTYA 3H67A 1QHWA 3DW8C 4O5GA 1Z2WA 2Z1AA 3HVQA 1HO5A 3GVEA 1S3LA 1JK7A 4FBWA 1T71A 1HP1A 2O8GA 3IVEA 3DSCA 4TUIA 2IE3C 3H61A 1SU1A 3QFNA 3T1IA 5JPEA 2WDEA 1OIDA 1XM7A 4IYPC 1MF8A 5C1VA 2NYLC 1S70A 2IAEC 4MP0A 3E7BA 3CK2A 4FCXA 1IT6A 3AUZA 1WARA 3QFOA 2HYOA 4I5NC 2HYPA 4DSYA 3AV0A 2Z72A 4NZVA 4O24A 4H1YP 2BCDA 3RL3A 4KBPA 4B2OA 4H1SA 4H2IA 3RL4A 3QG5C 3THNA 4H2FA 2KKNA 3RL5A 1S95A 4DT2A 2ZO9B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QFP A;  4FBK A;  4ORA A;  4WWL A;  1UTE A;  4XPN A;  4UT3 B;  1Z2X A;  3ZU0 A;  3DSD A;  5DNY A;  2QFR A;  1G5B A;  3EGH A;  3C5W C;  5J28 A;  1HPU A;  4V0V A;  2USH A;  2GJU A;  2YVT A;  1KBP A;  4Q7F A;  3H69 A;  3H63 A;  2WDD A;  4LAC C;  4H2G A;  3E7A A;  3LL8 A;  4J6O A;  1OI8 A;  4G9J A;  2A22 A;  3H64 A;  3RQZ A;  2DFJ A;  2P6B A;  4MOV A;  3V4Y A;  1XZW A;  2Z06 A;  3QFM A;  1S8E A;  4FBQ A;  1T70 A;  3H60 A;  1WAO 1;  5F3W A;  4ZVZ A;  1M63 A;  1QFC A;  2CV9 A;  2NPP C;  4LU9 A;  2QJC A;  1USH A;  5INB A;  5JJT A;  1II7 A;  1S3N A;  1S3M A;  3FGA C;  3ICF A;  4ZX2 A;  5HPE A;  4DHL A;  4HD0 A;  2HY1 A;  3THO B;  3P71 C;  4TUG A;  3N5U A;  3QFK A;  2IE4 C;  3C9F A;  4V0X A;  5B8I A;  1UF3 A;  4JA7 A;  1TCO A;  4JA9 A;  2NYM C;  2R17 A;  3H68 A;  3K7V C;  4YKE A;  4UT3 A;  2ZBM A;  3KBP A;  4IL1 A;  2WDC A;  4UWQ A;  3K7W C;  4I5L C;  3EGG A;  2NXF A;  4F0Z A;  1FJM A;  3JYF A;  3H62 B;  1U32 A;  4ORB A;  1OIE A;  2O8A A;  5IOH A;  4ORC A;  4OR9 A;  5JPF A;  1W24 A;  4O43 A;  1AUI A;  4V0W A;  2XMO A;  3TGH A;  3PSO A;  2WDF A;  3PSN A;  4M0V A;  2BQ8 X;  2AHD A;  2JOG A;  3IB8 A;  3IVD A;  4O4K A;  4UT2 A;  1NNW A;  5EQV A;  4H2B A;  3ZTV A;  4KKZ A;  2Q8U A;  5GTU A;  1V73 A;  3H66 A;  2BDX A;  3IB7 A;  4MOY A;  4LTY A;  3H67 A;  1QHW A;  3DW8 C;  4O5G A;  1Z2W A;  2Z1A A;  3HVQ A;  1HO5 A;  3GVE A;  1S3L A;  1JK7 A;  4FBW A;  1T71 A;  1HP1 A;  2O8G A;  3IVE A;  3DSC A;  4TUI A;  2IE3 C;  3H61 A;  1SU1 A;  3QFN A;  3T1I A;  5JPE A;  2WDE A;  1OID A;  1XM7 A;  4IYP C;  1MF8 A;  5C1V A;  2NYL C;  1S70 A;  2IAE C;  4MP0 A;  3E7B A;  3CK2 A;  4FCX A;  1IT6 A;  3AUZ A;  1WAR A;  3QFO A;  2HYO A;  4I5N C;  2HYP A;  4DSY A;  3AV0 A;  2Z72 A;  4NZV A;  4O24 A;  4H1Y P;  2BCD A;  3RL3 A;  4KBP A;  4B2O A;  4H1S A;  4H2I A;  3RL4 A;  3QG5 C;  3THN A;  4H2F A;  2KKN A;  3RL5 A;  1S95 A;  4DT2 A; 
#chains in the Genus database with same CATH topology
 2QFP A;  4FBK A;  4ORA A;  4WWL A;  1UTE A;  4XPN A;  3E0J A;  4UT3 B;  1Z2X A;  3ZU0 A;  3DSD A;  5DNY A;  2DXL A;  2QFR A;  1G5B A;  3EGH A;  3C5W C;  5J28 A;  1HPU A;  4V0V A;  2USH A;  2GJU A;  2YVT A;  1KBP A;  4Q7F A;  3H69 A;  3H63 A;  2WDD A;  4LAC C;  4H2G A;  3E7A A;  3LL8 A;  4J6O A;  1OI8 A;  4G9J A;  2A22 A;  3H64 A;  3RQZ A;  2DFJ A;  2P6B A;  4MOV A;  3V4Y A;  1XZW A;  2Z06 A;  3QFM A;  1S8E A;  4FBQ A;  1T70 A;  3H60 A;  1WAO 1;  5F3W A;  4ZVZ A;  1M63 A;  1QFC A;  2CV9 A;  2NPP C;  4LU9 A;  2QJC A;  1USH A;  5INB A;  5JJT A;  1II7 A;  1S3N A;  1S3M A;  3FGA C;  3ICF A;  3FLO A;  4ZX2 A;  5HPE A;  4DHL A;  4HD0 A;  2HY1 A;  3THO B;  3P71 C;  4TUG A;  3N5U A;  3QFK A;  2IE4 C;  3C9F A;  4V0X A;  5B8I A;  1UF3 A;  4JA7 A;  1TCO A;  4JA9 A;  2NYM C;  2R17 A;  3H68 A;  3K7V C;  4YKE A;  4UT3 A;  2ZBM A;  3KBP A;  4IL1 A;  2WDC A;  4UWQ A;  3K7W C;  4I5L C;  3EGG A;  2NXF A;  4F0Z A;  1FJM A;  3JYF A;  3H62 B;  1U32 A;  4ORB A;  1OIE A;  2O8A A;  5IOH A;  4ORC A;  4OR9 A;  5JPF A;  1W24 A;  4O43 A;  2DXN A;  1AUI A;  4V0W A;  2XMO A;  3TGH A;  3PSO A;  2WDF A;  3D03 A;  3PSN A;  4M0V A;  2BQ8 X;  2AHD A;  2JOG A;  2YEQ A;  3IB8 A;  3IVD A;  4O4K A;  4UT2 A;  1NNW A;  5EQV A;  4H2B A;  3ZTV A;  4KKZ A;  2Q8U A;  5GTU A;  2ZOA A;  1V73 A;  3H66 A;  2BDX A;  3IB7 A;  4MOY A;  4LTY A;  3H67 A;  1QHW A;  3DW8 C;  4O5G A;  1Z2W A;  2Z1A A;  3HVQ A;  1HO5 A;  3GVE A;  1S3L A;  1JK7 A;  4FBW A;  1T71 A;  1HP1 A;  2O8G A;  3IVE A;  3DSC A;  4TUI A;  2IE3 C;  3H61 A;  1SU1 A;  3QFN A;  3T1I A;  5JPE A;  2WDE A;  1OID A;  1XM7 A;  4IYP C;  1MF8 A;  5C1V A;  2NYL C;  1S70 A;  2IAE C;  4MP0 A;  3E7B A;  3CK2 A;  4FCX A;  1IT6 A;  3AUZ A;  1WAR A;  3QFO A;  2HYO A;  4I5N C;  2HYP A;  4DSY A;  3AV0 A;  2Z72 A;  4NZV A;  4O24 A;  4H1Y P;  2BCD A;  3RL3 A;  4KBP A;  4B2O A;  4H1S A;  4H2I A;  3RL4 A;  3QG5 C;  3THN A;  4H2F A;  2KKN A;  3RL5 A;  1S95 A;  4DT2 A;  2ZO9 B; 
#chains in the Genus database with same CATH homology
 2QFP A;  4FBK A;  4ORA A;  4WWL A;  1UTE A;  4XPN A;  3E0J A;  4UT3 B;  1Z2X A;  3ZU0 A;  3DSD A;  5DNY A;  2DXL A;  2QFR A;  1G5B A;  3EGH A;  3C5W C;  5J28 A;  1HPU A;  4V0V A;  2USH A;  2GJU A;  2YVT A;  1KBP A;  4Q7F A;  3H69 A;  3H63 A;  2WDD A;  4LAC C;  4H2G A;  3E7A A;  3LL8 A;  4J6O A;  1OI8 A;  4G9J A;  2A22 A;  3H64 A;  3RQZ A;  2DFJ A;  2P6B A;  4MOV A;  3V4Y A;  1XZW A;  2Z06 A;  3QFM A;  1S8E A;  4FBQ A;  1T70 A;  3H60 A;  1WAO 1;  5F3W A;  4ZVZ A;  1M63 A;  1QFC A;  2CV9 A;  2NPP C;  4LU9 A;  2QJC A;  1USH A;  5INB A;  5JJT A;  1II7 A;  1S3N A;  1S3M A;  3FGA C;  3ICF A;  3FLO A;  4ZX2 A;  5HPE A;  4DHL A;  4HD0 A;  2HY1 A;  3THO B;  3P71 C;  4TUG A;  3N5U A;  3QFK A;  2IE4 C;  3C9F A;  4V0X A;  5B8I A;  1UF3 A;  4JA7 A;  1TCO A;  4JA9 A;  2NYM C;  2R17 A;  3H68 A;  3K7V C;  4YKE A;  4UT3 A;  2ZBM A;  3KBP A;  4IL1 A;  2WDC A;  4UWQ A;  3K7W C;  4I5L C;  3EGG A;  2NXF A;  4F0Z A;  1FJM A;  3JYF A;  3H62 B;  1U32 A;  4ORB A;  1OIE A;  2O8A A;  5IOH A;  4ORC A;  4OR9 A;  5JPF A;  1W24 A;  4O43 A;  2DXN A;  1AUI A;  4V0W A;  2XMO A;  3TGH A;  3PSO A;  2WDF A;  3D03 A;  3PSN A;  4M0V A;  2BQ8 X;  2AHD A;  2JOG A;  2YEQ A;  3IB8 A;  3IVD A;  4O4K A;  4UT2 A;  1NNW A;  5EQV A;  4H2B A;  3ZTV A;  4KKZ A;  2Q8U A;  5GTU A;  2ZOA A;  1V73 A;  3H66 A;  2BDX A;  3IB7 A;  4MOY A;  4LTY A;  3H67 A;  1QHW A;  3DW8 C;  4O5G A;  1Z2W A;  2Z1A A;  3HVQ A;  1HO5 A;  3GVE A;  1S3L A;  1JK7 A;  4FBW A;  1T71 A;  1HP1 A;  2O8G A;  3IVE A;  3DSC A;  4TUI A;  2IE3 C;  3H61 A;  1SU1 A;  3QFN A;  3T1I A;  5JPE A;  2WDE A;  1OID A;  1XM7 A;  4IYP C;  1MF8 A;  5C1V A;  2NYL C;  1S70 A;  2IAE C;  4MP0 A;  3E7B A;  3CK2 A;  4FCX A;  1IT6 A;  3AUZ A;  1WAR A;  3QFO A;  2HYO A;  4I5N C;  2HYP A;  4DSY A;  3AV0 A;  2Z72 A;  4NZV A;  4O24 A;  4H1Y P;  2BCD A;  3RL3 A;  4KBP A;  4B2O A;  4H1S A;  4H2I A;  3RL4 A;  3QG5 C;  3THN A;  4H2F A;  2KKN A;  3RL5 A;  1S95 A;  4DT2 A;  2ZO9 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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