2NYLC

Crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 91
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nylC00
3P71C 2NPPC 3CK2A 4Q7FA 3KBPA 1U32A 2WDEA 5EQVA 5JJTA 2ZBMA 4I5LC 4ZX2A 5DNYA 3JYFA 4ORCA 1W24A 4FCXA 4UT2A 2BQ8X 3QG5C 3GVEA 1T70A 4H2BA 4UT3B 1KBPA 3H62B 1XZWA 3FGAC 2QJCA 4M0VA 1OIDA 1JK7A 1S95A 3THOB 2QFRA 1S70A 2WDFA 5B8IA 4G9JA 3H69A 1WARA 3RL5A 4KKZA 3C5WC 3HVQA 2KKNA 2IE3C 4KBPA 4B2OA 3DSCA 2HYOA 2Q8UA 1II7A 4JA9A 2NYMC 1M63A 4FBWA 1G5BA 3RL4A 1USHA 2CV9A 2NXFA 5GTUA 2Z1AA 3H63A 4ORBA 3PSNA 4I5NC 2A22A 1HO5A 1Z2WA 3QFKA 4MOYA 4WWLA 4YKEA 2Z06A 3K7VC 4H2FA 3ICFA 3K7WC 4V0WA 5INBA 2YVTA 3V4YA 4O43A 2R17A 1T71A 4TUGA 4XPNA 2HYPA 2QFPA 3H67A 2JOGA 2USHA 4UT3A 2XMOA 3N5UA 5C1VA 4H2IA 3H61A 1MF8A 4DSYA 1XM7A 1IT6A 1TCOA 4ORAA 1QFCA 1S3MA 3IB7A 4H1YP 3LL8A 4V0VA 2BCDA 3H66A 4F0ZA 1UF3A 4FBKA 4MOVA 2Z72A 1HPUA 1OI8A 1WAO1 2DFJA 2O8AA 1S8EA 4HD0A 1Z2XA 3QFOA 3DSDA 5J28A 2IE4C 5IOHA 4UWQA 2HY1A 3H64A 5F3WA 4IYPC 3QFNA 2WDCA 4DT2A 3AUZA 3PSOA 4H2GA 3TGHA 2IAEC 4J6OA 2AHDA 2O8GA 3IVDA 3IVEA 4MP0A 2BDXA 3RL3A 3E7AA 3H68A 1NNWA 3ZU0A 1HP1A 4TUIA 3RQZA 4O4KA 5HPEA 1FJMA 3EGGA 1UTEA 1QHWA 1OIEA 3C9FA 3IB8A 4OR9A 4V0XA 2NYLC 3E7BA 2GJUA 2P6BA 3T1IA 4O24A 1S3NA 4JA7A 4LU9A 3QFMA 4LACC 4NZVA 3EGHA 1SU1A 4ZVZA 1AUIA 4DHLA 4FBQA 4O5GA 2WDDA 3ZTVA 4LTYA 4H1SA 3DW8C 4IL1A 5JPFA 3H60A 3AV0A 5JPEA 1S3LA 3THNA 1V73A
chains in the Genus database with same CATH superfamily
3P71C 2NPPC 3CK2A 4Q7FA 3KBPA 1U32A 2WDEA 5EQVA 5JJTA 2ZBMA 4I5LC 4ZX2A 5DNYA 3JYFA 4ORCA 1W24A 4FCXA 4UT2A 2BQ8X 3QG5C 3GVEA 1T70A 2YEQA 4H2BA 1KBPA 3H62B 1XZWA 3FGAC 4UT3B 2QJCA 4M0VA 1OIDA 1JK7A 1S95A 3THOB 2QFRA 1S70A 2WDFA 5B8IA 4G9JA 3H69A 1WARA 3RL5A 4KKZA 3C5WC 3HVQA 2KKNA 2IE3C 4KBPA 4B2OA 3DSCA 2HYOA 2Q8UA 1II7A 4JA9A 2NYMC 1M63A 4FBWA 1G5BA 3RL4A 1USHA 2CV9A 2NXFA 5GTUA 2Z1AA 3H63A 2DXLA 4ORBA 3PSNA 4I5NC 2A22A 1HO5A 1Z2WA 3QFKA 4MOYA 4WWLA 4YKEA 2Z06A 2ZOAA 3K7VC 4H2FA 3ICFA 3K7WC 4V0WA 5INBA 2YVTA 3D03A 3V4YA 4O43A 2R17A 1T71A 4TUGA 4XPNA 2HYPA 2QFPA 3H67A 2JOGA 2USHA 4UT3A 2XMOA 3N5UA 5C1VA 4H2IA 3H61A 1MF8A 4DSYA 1XM7A 1IT6A 1TCOA 4ORAA 1QFCA 1S3MA 3IB7A 4H1YP 3LL8A 3FLOA 4V0VA 2BCDA 3H66A 4F0ZA 1UF3A 4FBKA 4MOVA 2Z72A 1HPUA 1OI8A 1WAO1 2DFJA 2O8AA 1S8EA 3E0JA 1Z2XA 2ZO9B 3QFOA 4HD0A 3DSDA 5J28A 2IE4C 5IOHA 4UWQA 2HY1A 3H64A 5F3WA 4IYPC 3QFNA 2WDCA 4DT2A 3AUZA 3PSOA 4H2GA 3TGHA 2IAEC 4J6OA 2AHDA 2O8GA 3IVDA 3IVEA 4MP0A 3T1IA 2BDXA 3RL3A 3E7AA 3H68A 1NNWA 3ZU0A 1HP1A 4TUIA 3RQZA 4O4KA 5HPEA 1FJMA 3EGGA 1UTEA 1QHWA 1OIEA 3C9FA 3IB8A 4OR9A 4V0XA 2DXNA 2NYLC 2GJUA 2P6BA 3E7BA 4O24A 1S3NA 4JA7A 4LU9A 3QFMA 4LACC 4NZVA 3EGHA 1SU1A 4ZVZA 1AUIA 4DHLA 4FBQA 4O5GA 2WDDA 3ZTVA 4LTYA 4H1SA 3DW8C 4IL1A 5JPFA 3H60A 3AV0A 5JPEA 1S3LA 3THNA 1V73A
chains in the Genus database with same CATH topology
3P71C 2NPPC 3CK2A 4Q7FA 3KBPA 1U32A 2WDEA 5EQVA 5JJTA 2ZBMA 4I5LC 4ZX2A 5DNYA 3JYFA 4ORCA 1W24A 4FCXA 4UT2A 2BQ8X 3QG5C 3GVEA 1T70A 2YEQA 4H2BA 1KBPA 3H62B 1XZWA 3FGAC 4UT3B 2QJCA 4M0VA 1OIDA 1JK7A 1S95A 3THOB 2QFRA 1S70A 2WDFA 5B8IA 4G9JA 3H69A 1WARA 3RL5A 4KKZA 3C5WC 3HVQA 2KKNA 2IE3C 4KBPA 4B2OA 3DSCA 2HYOA 2Q8UA 1II7A 4JA9A 2NYMC 1M63A 4FBWA 1G5BA 3RL4A 1USHA 2CV9A 2NXFA 5GTUA 2Z1AA 3H63A 2DXLA 4ORBA 3PSNA 4I5NC 2A22A 1HO5A 1Z2WA 3QFKA 4MOYA 4WWLA 4YKEA 2Z06A 2ZOAA 3K7VC 4H2FA 3ICFA 3K7WC 4V0WA 5INBA 2YVTA 3D03A 3V4YA 4O43A 2R17A 1T71A 4TUGA 4XPNA 2HYPA 2QFPA 3H67A 2JOGA 2USHA 4UT3A 2XMOA 3N5UA 5C1VA 4H2IA 3H61A 1MF8A 4DSYA 1XM7A 1IT6A 1TCOA 4ORAA 1QFCA 1S3MA 3IB7A 4H1YP 3LL8A 3FLOA 4V0VA 2BCDA 3H66A 4F0ZA 1UF3A 4FBKA 4MOVA 2Z72A 1HPUA 1OI8A 1WAO1 2DFJA 2O8AA 1S8EA 3E0JA 1Z2XA 2ZO9B 3QFOA 4HD0A 3DSDA 5J28A 2IE4C 5IOHA 4UWQA 2HY1A 3H64A 5F3WA 4IYPC 3QFNA 2WDCA 4DT2A 3AUZA 3PSOA 4H2GA 3TGHA 2IAEC 4J6OA 2AHDA 2O8GA 3IVDA 3IVEA 4MP0A 3T1IA 2BDXA 3RL3A 3E7AA 3H68A 1NNWA 3ZU0A 1HP1A 4TUIA 3RQZA 4O4KA 5HPEA 1FJMA 3EGGA 1UTEA 1QHWA 1OIEA 3C9FA 3IB8A 4OR9A 4V0XA 2DXNA 2NYLC 2GJUA 2P6BA 3E7BA 4O24A 1S3NA 4JA7A 4LU9A 3QFMA 4LACC 4NZVA 3EGHA 1SU1A 4ZVZA 1AUIA 4DHLA 4FBQA 4O5GA 2WDDA 3ZTVA 4LTYA 4H1SA 3DW8C 4IL1A 5JPFA 3H60A 3AV0A 5JPEA 1S3LA 3THNA 1V73A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P71 C;  2NPP C;  3CK2 A;  4Q7F A;  3KBP A;  1U32 A;  2WDE A;  5EQV A;  5JJT A;  2ZBM A;  4I5L C;  4ZX2 A;  5DNY A;  3JYF A;  4ORC A;  1W24 A;  4FCX A;  4UT2 A;  2BQ8 X;  3QG5 C;  3GVE A;  1T70 A;  4H2B A;  4UT3 B;  1KBP A;  3H62 B;  1XZW A;  3FGA C;  2QJC A;  4M0V A;  1OID A;  1JK7 A;  1S95 A;  3THO B;  2QFR A;  1S70 A;  2WDF A;  5B8I A;  4G9J A;  3H69 A;  1WAR A;  3RL5 A;  4KKZ A;  3C5W C;  3HVQ A;  2KKN A;  2IE3 C;  4KBP A;  4B2O A;  3DSC A;  2HYO A;  2Q8U A;  1II7 A;  4JA9 A;  2NYM C;  1M63 A;  4FBW A;  1G5B A;  3RL4 A;  1USH A;  2CV9 A;  2NXF A;  5GTU A;  2Z1A A;  3H63 A;  4ORB A;  3PSN A;  4I5N C;  2A22 A;  1HO5 A;  1Z2W A;  3QFK A;  4MOY A;  4WWL A;  4YKE A;  2Z06 A;  3K7V C;  4H2F A;  3ICF A;  3K7W C;  4V0W A;  5INB A;  2YVT A;  3V4Y A;  4O43 A;  2R17 A;  1T71 A;  4TUG A;  4XPN A;  2HYP A;  2QFP A;  3H67 A;  2JOG A;  2USH A;  4UT3 A;  2XMO A;  3N5U A;  5C1V A;  4H2I A;  3H61 A;  1MF8 A;  4DSY A;  1XM7 A;  1IT6 A;  1TCO A;  4ORA A;  1QFC A;  1S3M A;  3IB7 A;  4H1Y P;  3LL8 A;  4V0V A;  2BCD A;  3H66 A;  4F0Z A;  1UF3 A;  4FBK A;  4MOV A;  2Z72 A;  1HPU A;  1OI8 A;  1WAO 1;  2DFJ A;  2O8A A;  1S8E A;  4HD0 A;  1Z2X A;  3QFO A;  3DSD A;  5J28 A;  2IE4 C;  5IOH A;  4UWQ A;  2HY1 A;  3H64 A;  5F3W A;  4IYP C;  3QFN A;  2WDC A;  4DT2 A;  3AUZ A;  3PSO A;  4H2G A;  3TGH A;  2IAE C;  4J6O A;  2AHD A;  2O8G A;  3IVD A;  3IVE A;  4MP0 A;  2BDX A;  3RL3 A;  3E7A A;  3H68 A;  1NNW A;  3ZU0 A;  1HP1 A;  4TUI A;  3RQZ A;  4O4K A;  5HPE A;  1FJM A;  3EGG A;  1UTE A;  1QHW A;  1OIE A;  3C9F A;  3IB8 A;  4OR9 A;  4V0X A;  2NYL C;  3E7B A;  2GJU A;  2P6B A;  3T1I A;  4O24 A;  1S3N A;  4JA7 A;  4LU9 A;  3QFM A;  4LAC C;  4NZV A;  3EGH A;  1SU1 A;  4ZVZ A;  1AUI A;  4DHL A;  4FBQ A;  4O5G A;  2WDD A;  3ZTV A;  4LTY A;  4H1S A;  3DW8 C;  4IL1 A;  5JPF A;  3H60 A;  3AV0 A;  5JPE A;  1S3L A;  3THN A;  1V73 A; 
#chains in the Genus database with same CATH topology
 3P71 C;  2NPP C;  3CK2 A;  4Q7F A;  3KBP A;  1U32 A;  2WDE A;  5EQV A;  5JJT A;  2ZBM A;  4I5L C;  4ZX2 A;  5DNY A;  3JYF A;  4ORC A;  1W24 A;  4FCX A;  4UT2 A;  2BQ8 X;  3QG5 C;  3GVE A;  1T70 A;  2YEQ A;  4H2B A;  1KBP A;  3H62 B;  1XZW A;  3FGA C;  4UT3 B;  2QJC A;  4M0V A;  1OID A;  1JK7 A;  1S95 A;  3THO B;  2QFR A;  1S70 A;  2WDF A;  5B8I A;  4G9J A;  3H69 A;  1WAR A;  3RL5 A;  4KKZ A;  3C5W C;  3HVQ A;  2KKN A;  2IE3 C;  4KBP A;  4B2O A;  3DSC A;  2HYO A;  2Q8U A;  1II7 A;  4JA9 A;  2NYM C;  1M63 A;  4FBW A;  1G5B A;  3RL4 A;  1USH A;  2CV9 A;  2NXF A;  5GTU A;  2Z1A A;  3H63 A;  2DXL A;  4ORB A;  3PSN A;  4I5N C;  2A22 A;  1HO5 A;  1Z2W A;  3QFK A;  4MOY A;  4WWL A;  4YKE A;  2Z06 A;  2ZOA A;  3K7V C;  4H2F A;  3ICF A;  3K7W C;  4V0W A;  5INB A;  2YVT A;  3D03 A;  3V4Y A;  4O43 A;  2R17 A;  1T71 A;  4TUG A;  4XPN A;  2HYP A;  2QFP A;  3H67 A;  2JOG A;  2USH A;  4UT3 A;  2XMO A;  3N5U A;  5C1V A;  4H2I A;  3H61 A;  1MF8 A;  4DSY A;  1XM7 A;  1IT6 A;  1TCO A;  4ORA A;  1QFC A;  1S3M A;  3IB7 A;  4H1Y P;  3LL8 A;  3FLO A;  4V0V A;  2BCD A;  3H66 A;  4F0Z A;  1UF3 A;  4FBK A;  4MOV A;  2Z72 A;  1HPU A;  1OI8 A;  1WAO 1;  2DFJ A;  2O8A A;  1S8E A;  3E0J A;  1Z2X A;  2ZO9 B;  3QFO A;  4HD0 A;  3DSD A;  5J28 A;  2IE4 C;  5IOH A;  4UWQ A;  2HY1 A;  3H64 A;  5F3W A;  4IYP C;  3QFN A;  2WDC A;  4DT2 A;  3AUZ A;  3PSO A;  4H2G A;  3TGH A;  2IAE C;  4J6O A;  2AHD A;  2O8G A;  3IVD A;  3IVE A;  4MP0 A;  3T1I A;  2BDX A;  3RL3 A;  3E7A A;  3H68 A;  1NNW A;  3ZU0 A;  1HP1 A;  4TUI A;  3RQZ A;  4O4K A;  5HPE A;  1FJM A;  3EGG A;  1UTE A;  1QHW A;  1OIE A;  3C9F A;  3IB8 A;  4OR9 A;  4V0X A;  2DXN A;  2NYL C;  2GJU A;  2P6B A;  3E7B A;  4O24 A;  1S3N A;  4JA7 A;  4LU9 A;  3QFM A;  4LAC C;  4NZV A;  3EGH A;  1SU1 A;  4ZVZ A;  1AUI A;  4DHL A;  4FBQ A;  4O5G A;  2WDD A;  3ZTV A;  4LTY A;  4H1S A;  3DW8 C;  4IL1 A;  5JPF A;  3H60 A;  3AV0 A;  5JPE A;  1S3L A;  3THN A;  1V73 A; 
#chains in the Genus database with same CATH homology
 3P71 C;  2NPP C;  3CK2 A;  4Q7F A;  3KBP A;  1U32 A;  2WDE A;  5EQV A;  5JJT A;  2ZBM A;  4I5L C;  4ZX2 A;  5DNY A;  3JYF A;  4ORC A;  1W24 A;  4FCX A;  4UT2 A;  2BQ8 X;  3QG5 C;  3GVE A;  1T70 A;  2YEQ A;  4H2B A;  1KBP A;  3H62 B;  1XZW A;  3FGA C;  4UT3 B;  2QJC A;  4M0V A;  1OID A;  1JK7 A;  1S95 A;  3THO B;  2QFR A;  1S70 A;  2WDF A;  5B8I A;  4G9J A;  3H69 A;  1WAR A;  3RL5 A;  4KKZ A;  3C5W C;  3HVQ A;  2KKN A;  2IE3 C;  4KBP A;  4B2O A;  3DSC A;  2HYO A;  2Q8U A;  1II7 A;  4JA9 A;  2NYM C;  1M63 A;  4FBW A;  1G5B A;  3RL4 A;  1USH A;  2CV9 A;  2NXF A;  5GTU A;  2Z1A A;  3H63 A;  2DXL A;  4ORB A;  3PSN A;  4I5N C;  2A22 A;  1HO5 A;  1Z2W A;  3QFK A;  4MOY A;  4WWL A;  4YKE A;  2Z06 A;  2ZOA A;  3K7V C;  4H2F A;  3ICF A;  3K7W C;  4V0W A;  5INB A;  2YVT A;  3D03 A;  3V4Y A;  4O43 A;  2R17 A;  1T71 A;  4TUG A;  4XPN A;  2HYP A;  2QFP A;  3H67 A;  2JOG A;  2USH A;  4UT3 A;  2XMO A;  3N5U A;  5C1V A;  4H2I A;  3H61 A;  1MF8 A;  4DSY A;  1XM7 A;  1IT6 A;  1TCO A;  4ORA A;  1QFC A;  1S3M A;  3IB7 A;  4H1Y P;  3LL8 A;  3FLO A;  4V0V A;  2BCD A;  3H66 A;  4F0Z A;  1UF3 A;  4FBK A;  4MOV A;  2Z72 A;  1HPU A;  1OI8 A;  1WAO 1;  2DFJ A;  2O8A A;  1S8E A;  3E0J A;  1Z2X A;  2ZO9 B;  3QFO A;  4HD0 A;  3DSD A;  5J28 A;  2IE4 C;  5IOH A;  4UWQ A;  2HY1 A;  3H64 A;  5F3W A;  4IYP C;  3QFN A;  2WDC A;  4DT2 A;  3AUZ A;  3PSO A;  4H2G A;  3TGH A;  2IAE C;  4J6O A;  2AHD A;  2O8G A;  3IVD A;  3IVE A;  4MP0 A;  3T1I A;  2BDX A;  3RL3 A;  3E7A A;  3H68 A;  1NNW A;  3ZU0 A;  1HP1 A;  4TUI A;  3RQZ A;  4O4K A;  5HPE A;  1FJM A;  3EGG A;  1UTE A;  1QHW A;  1OIE A;  3C9F A;  3IB8 A;  4OR9 A;  4V0X A;  2DXN A;  2NYL C;  2GJU A;  2P6B A;  3E7B A;  4O24 A;  1S3N A;  4JA7 A;  4LU9 A;  3QFM A;  4LAC C;  4NZV A;  3EGH A;  1SU1 A;  4ZVZ A;  1AUI A;  4DHL A;  4FBQ A;  4O5G A;  2WDD A;  3ZTV A;  4LTY A;  4H1S A;  3DW8 C;  4IL1 A;  5JPF A;  3H60 A;  3AV0 A;  5JPE A;  1S3L A;  3THN A;  1V73 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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