2NYMC

Crystal structure of protein phosphatase 2a (pp2a) with c-terminus truncated catalytic subunit
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein phosphatase 2
total genus 88
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nymC00
3IB7A 2O8AA 4TUIA 4V0XA 4V0VA 2Z06A 2QFPA 4JA7A 4UWQA 1Z2XA 3H60A 1UTEA 1NNWA 3H68A 3HVQA 5F3WA 2R17A 1OI8A 2NPPC 1QHWA 1M63A 5EQVA 4FBKA 4V0WA 2NYMC 3K7VC 4H2GA 2HYPA 3QFOA 4O43A 4H1SA 3ICFA 1T71A 5JPFA 4H2FA 3EGGA 1S70A 1XZWA 4F0ZA 2IE4C 4LACC 4IYPC 1OIDA 2HY1A 2HYOA 2WDFA 4H2IA 4MOYA 4I5LC 2IE3C 4O5GA 1S95A 1S8EA 4NZVA 2AHDA 1U32A 4G9JA 1JK7A 4B2OA 4XPNA 3E7AA 1OIEA 3H67A 1WARA 5C1VA 3QFNA 1KBPA 3C9FA 3H63A 1S3LA 1V73A 4ZVZA 2JOGA 2WDDA 2Z1AA 3QFMA 4KBPA 2P6BA 3ZU0A 2DFJA 4ORBA 1W24A 2BDXA 2BQ8X 3DW8C 5INBA 3RL5A 3THNA 1G5BA 1HPUA 4UT3B 3IB8A 1S3NA 2QJCA 2USHA 3KBPA 3V4YA 3C5WC 3DSCA 1S3MA 3RL4A 2YVTA 4TUGA 2XMOA 3RL3A 3PSNA 4LU9A 3AV0A 3H69A 4MOVA 3EGHA 5B8IA 3TGHA 3LL8A 4WWLA 3FGAC 4ORCA 2Q8UA 3QG5C 3IVDA 4Q7FA 2O8GA 5GTUA 3RQZA 4O4KA 4FBWA 3THOB 3N5UA 4O24A 5HPEA 4I5NC 2GJUA 1AUIA 3CK2A 5J28A 4ORAA 1T70A 4H2BA 5IOHA 4KKZA 2KKNA 3T1IA 3E7BA 2WDEA 2IAEC 3PSOA 1Z2WA 2CV9A 4J6OA 2A22A 3H66A 1XM7A 3H64A 1HO5A 3H61A 5JPEA 4OR9A 1HP1A 2WDCA 2BCDA 3AUZA 3K7WC 1USHA 3GVEA 4HD0A 3JYFA 4JA9A 1WAO1 4DT2A 1FJMA 1IT6A 2NXFA 4UT2A 4FBQA 4YKEA 3ZTVA 4MP0A 1TCOA 5JJTA 4FCXA 1II7A 2ZBMA 3H62B 3P71C 4DHLA 4IL1A 1SU1A 2Z72A 4ZX2A 1MF8A 4LTYA 2NYLC 1QFCA 4UT3A 3QFKA 2QFRA 4H1YP 3IVEA 4M0VA 5DNYA 3DSDA 1UF3A 4DSYA
chains in the Genus database with same CATH superfamily
3IB7A 2O8AA 4TUIA 4V0XA 2ZO9B 4V0VA 3D03A 2Z06A 2QFPA 4JA7A 4UWQA 1Z2XA 3H60A 1UTEA 1NNWA 3H68A 3HVQA 5F3WA 2YEQA 2R17A 1OI8A 2NPPC 1QHWA 1M63A 5EQVA 4FBKA 4V0WA 2NYMC 3K7VC 4H2GA 2HYPA 3QFOA 4O43A 4H1SA 3ICFA 1T71A 5JPFA 4H2FA 3EGGA 1S70A 1XZWA 2DXNA 4F0ZA 2IE4C 4LACC 4IYPC 1OIDA 2HY1A 2HYOA 2WDFA 4H2IA 4MOYA 4I5LC 2IE3C 4O5GA 1S95A 1S8EA 4NZVA 2AHDA 1U32A 4G9JA 1JK7A 4B2OA 4XPNA 3E7AA 1OIEA 3H67A 1WARA 5C1VA 3QFNA 1KBPA 3C9FA 3H63A 1S3LA 1V73A 4ZVZA 2JOGA 2WDDA 2Z1AA 3QFMA 4KBPA 2P6BA 3ZU0A 2DFJA 4ORBA 1W24A 2BDXA 2BQ8X 3DW8C 5INBA 3RL5A 3THNA 1G5BA 1HPUA 4UT3B 3IB8A 1S3NA 2QJCA 2USHA 3KBPA 3V4YA 3C5WC 3DSCA 2DXLA 1S3MA 3RL4A 2YVTA 4TUGA 2XMOA 3RL3A 3PSNA 4LU9A 3AV0A 3H69A 4MOVA 3EGHA 5B8IA 3TGHA 3LL8A 4WWLA 3FGAC 4ORCA 2Q8UA 2ZOAA 3IVDA 3QG5C 4Q7FA 2O8GA 5GTUA 3RQZA 4O4KA 4FBWA 3THOB 3N5UA 4O24A 5HPEA 4I5NC 2GJUA 1AUIA 3CK2A 5J28A 4ORAA 1T70A 4H2BA 5IOHA 3E0JA 4KKZA 2KKNA 3T1IA 3E7BA 2WDEA 2IAEC 3PSOA 1Z2WA 2CV9A 4J6OA 2A22A 3H66A 1XM7A 3FLOA 3H64A 1HO5A 3H61A 5JPEA 4OR9A 1HP1A 2WDCA 2BCDA 3AUZA 3K7WC 1USHA 3GVEA 4HD0A 3JYFA 4JA9A 1WAO1 4DT2A 1FJMA 1IT6A 2NXFA 4UT2A 4FBQA 4YKEA 3ZTVA 4MP0A 1TCOA 5JJTA 4FCXA 1II7A 2ZBMA 3H62B 3P71C 4DHLA 4IL1A 1SU1A 2Z72A 4ZX2A 1MF8A 4LTYA 2NYLC 1QFCA 4UT3A 3QFKA 2QFRA 4H1YP 3IVEA 4M0VA 5DNYA 3DSDA 1UF3A 4DSYA
chains in the Genus database with same CATH topology
3IB7A 2O8AA 4TUIA 4V0XA 2ZO9B 4V0VA 3D03A 2Z06A 2QFPA 4JA7A 4UWQA 1Z2XA 3H60A 1UTEA 1NNWA 3H68A 3HVQA 5F3WA 2YEQA 2R17A 1OI8A 2NPPC 1QHWA 1M63A 5EQVA 4FBKA 4V0WA 2NYMC 3K7VC 4H2GA 2HYPA 3QFOA 4O43A 4H1SA 3ICFA 1T71A 5JPFA 4H2FA 3EGGA 1S70A 1XZWA 2DXNA 4F0ZA 2IE4C 4LACC 4IYPC 1OIDA 2HY1A 2HYOA 2WDFA 4H2IA 4MOYA 4I5LC 2IE3C 4O5GA 1S95A 1S8EA 4NZVA 2AHDA 1U32A 4G9JA 1JK7A 4B2OA 4XPNA 3E7AA 1OIEA 3H67A 1WARA 5C1VA 3QFNA 1KBPA 3C9FA 3H63A 1S3LA 1V73A 4ZVZA 2JOGA 2WDDA 2Z1AA 3QFMA 4KBPA 2P6BA 3ZU0A 2DFJA 4ORBA 1W24A 2BDXA 2BQ8X 3DW8C 5INBA 3RL5A 3THNA 1G5BA 1HPUA 4UT3B 3IB8A 1S3NA 2QJCA 2USHA 3KBPA 3V4YA 3C5WC 3DSCA 2DXLA 1S3MA 3RL4A 2YVTA 4TUGA 2XMOA 3RL3A 3PSNA 4LU9A 3AV0A 3H69A 4MOVA 3EGHA 5B8IA 3TGHA 3LL8A 4WWLA 3FGAC 4ORCA 2Q8UA 2ZOAA 3IVDA 3QG5C 4Q7FA 2O8GA 5GTUA 3RQZA 4O4KA 4FBWA 3THOB 3N5UA 4O24A 5HPEA 4I5NC 2GJUA 1AUIA 3CK2A 5J28A 4ORAA 1T70A 4H2BA 5IOHA 3E0JA 4KKZA 2KKNA 3T1IA 3E7BA 2WDEA 2IAEC 3PSOA 1Z2WA 2CV9A 4J6OA 2A22A 3H66A 1XM7A 3FLOA 3H64A 1HO5A 3H61A 5JPEA 4OR9A 1HP1A 2WDCA 2BCDA 3AUZA 3K7WC 1USHA 3GVEA 4HD0A 3JYFA 4JA9A 1WAO1 4DT2A 1FJMA 1IT6A 2NXFA 4UT2A 4FBQA 4YKEA 3ZTVA 4MP0A 1TCOA 5JJTA 4FCXA 1II7A 2ZBMA 3H62B 3P71C 4DHLA 4IL1A 1SU1A 2Z72A 4ZX2A 1MF8A 4LTYA 2NYLC 1QFCA 4UT3A 3QFKA 2QFRA 4H1YP 3IVEA 4M0VA 5DNYA 3DSDA 1UF3A 4DSYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IB7 A;  2O8A A;  4TUI A;  4V0X A;  4V0V A;  2Z06 A;  2QFP A;  4JA7 A;  4UWQ A;  1Z2X A;  3H60 A;  1UTE A;  1NNW A;  3H68 A;  3HVQ A;  5F3W A;  2R17 A;  1OI8 A;  2NPP C;  1QHW A;  1M63 A;  5EQV A;  4FBK A;  4V0W A;  2NYM C;  3K7V C;  4H2G A;  2HYP A;  3QFO A;  4O43 A;  4H1S A;  3ICF A;  1T71 A;  5JPF A;  4H2F A;  3EGG A;  1S70 A;  1XZW A;  4F0Z A;  2IE4 C;  4LAC C;  4IYP C;  1OID A;  2HY1 A;  2HYO A;  2WDF A;  4H2I A;  4MOY A;  4I5L C;  2IE3 C;  4O5G A;  1S95 A;  1S8E A;  4NZV A;  2AHD A;  1U32 A;  4G9J A;  1JK7 A;  4B2O A;  4XPN A;  3E7A A;  1OIE A;  3H67 A;  1WAR A;  5C1V A;  3QFN A;  1KBP A;  3C9F A;  3H63 A;  1S3L A;  1V73 A;  4ZVZ A;  2JOG A;  2WDD A;  2Z1A A;  3QFM A;  4KBP A;  2P6B A;  3ZU0 A;  2DFJ A;  4ORB A;  1W24 A;  2BDX A;  2BQ8 X;  3DW8 C;  5INB A;  3RL5 A;  3THN A;  1G5B A;  1HPU A;  4UT3 B;  3IB8 A;  1S3N A;  2QJC A;  2USH A;  3KBP A;  3V4Y A;  3C5W C;  3DSC A;  1S3M A;  3RL4 A;  2YVT A;  4TUG A;  2XMO A;  3RL3 A;  3PSN A;  4LU9 A;  3AV0 A;  3H69 A;  4MOV A;  3EGH A;  5B8I A;  3TGH A;  3LL8 A;  4WWL A;  3FGA C;  4ORC A;  2Q8U A;  3QG5 C;  3IVD A;  4Q7F A;  2O8G A;  5GTU A;  3RQZ A;  4O4K A;  4FBW A;  3THO B;  3N5U A;  4O24 A;  5HPE A;  4I5N C;  2GJU A;  1AUI A;  3CK2 A;  5J28 A;  4ORA A;  1T70 A;  4H2B A;  5IOH A;  4KKZ A;  2KKN A;  3T1I A;  3E7B A;  2WDE A;  2IAE C;  3PSO A;  1Z2W A;  2CV9 A;  4J6O A;  2A22 A;  3H66 A;  1XM7 A;  3H64 A;  1HO5 A;  3H61 A;  5JPE A;  4OR9 A;  1HP1 A;  2WDC A;  2BCD A;  3AUZ A;  3K7W C;  1USH A;  3GVE A;  4HD0 A;  3JYF A;  4JA9 A;  1WAO 1;  4DT2 A;  1FJM A;  1IT6 A;  2NXF A;  4UT2 A;  4FBQ A;  4YKE A;  3ZTV A;  4MP0 A;  1TCO A;  5JJT A;  4FCX A;  1II7 A;  2ZBM A;  3H62 B;  3P71 C;  4DHL A;  4IL1 A;  1SU1 A;  2Z72 A;  4ZX2 A;  1MF8 A;  4LTY A;  2NYL C;  1QFC A;  4UT3 A;  3QFK A;  2QFR A;  4H1Y P;  3IVE A;  4M0V A;  5DNY A;  3DSD A;  1UF3 A;  4DSY A; 
#chains in the Genus database with same CATH topology
 3IB7 A;  2O8A A;  4TUI A;  4V0X A;  2ZO9 B;  4V0V A;  3D03 A;  2Z06 A;  2QFP A;  4JA7 A;  4UWQ A;  1Z2X A;  3H60 A;  1UTE A;  1NNW A;  3H68 A;  3HVQ A;  5F3W A;  2YEQ A;  2R17 A;  1OI8 A;  2NPP C;  1QHW A;  1M63 A;  5EQV A;  4FBK A;  4V0W A;  2NYM C;  3K7V C;  4H2G A;  2HYP A;  3QFO A;  4O43 A;  4H1S A;  3ICF A;  1T71 A;  5JPF A;  4H2F A;  3EGG A;  1S70 A;  1XZW A;  2DXN A;  4F0Z A;  2IE4 C;  4LAC C;  4IYP C;  1OID A;  2HY1 A;  2HYO A;  2WDF A;  4H2I A;  4MOY A;  4I5L C;  2IE3 C;  4O5G A;  1S95 A;  1S8E A;  4NZV A;  2AHD A;  1U32 A;  4G9J A;  1JK7 A;  4B2O A;  4XPN A;  3E7A A;  1OIE A;  3H67 A;  1WAR A;  5C1V A;  3QFN A;  1KBP A;  3C9F A;  3H63 A;  1S3L A;  1V73 A;  4ZVZ A;  2JOG A;  2WDD A;  2Z1A A;  3QFM A;  4KBP A;  2P6B A;  3ZU0 A;  2DFJ A;  4ORB A;  1W24 A;  2BDX A;  2BQ8 X;  3DW8 C;  5INB A;  3RL5 A;  3THN A;  1G5B A;  1HPU A;  4UT3 B;  3IB8 A;  1S3N A;  2QJC A;  2USH A;  3KBP A;  3V4Y A;  3C5W C;  3DSC A;  2DXL A;  1S3M A;  3RL4 A;  2YVT A;  4TUG A;  2XMO A;  3RL3 A;  3PSN A;  4LU9 A;  3AV0 A;  3H69 A;  4MOV A;  3EGH A;  5B8I A;  3TGH A;  3LL8 A;  4WWL A;  3FGA C;  4ORC A;  2Q8U A;  2ZOA A;  3IVD A;  3QG5 C;  4Q7F A;  2O8G A;  5GTU A;  3RQZ A;  4O4K A;  4FBW A;  3THO B;  3N5U A;  4O24 A;  5HPE A;  4I5N C;  2GJU A;  1AUI A;  3CK2 A;  5J28 A;  4ORA A;  1T70 A;  4H2B A;  5IOH A;  3E0J A;  4KKZ A;  2KKN A;  3T1I A;  3E7B A;  2WDE A;  2IAE C;  3PSO A;  1Z2W A;  2CV9 A;  4J6O A;  2A22 A;  3H66 A;  1XM7 A;  3FLO A;  3H64 A;  1HO5 A;  3H61 A;  5JPE A;  4OR9 A;  1HP1 A;  2WDC A;  2BCD A;  3AUZ A;  3K7W C;  1USH A;  3GVE A;  4HD0 A;  3JYF A;  4JA9 A;  1WAO 1;  4DT2 A;  1FJM A;  1IT6 A;  2NXF A;  4UT2 A;  4FBQ A;  4YKE A;  3ZTV A;  4MP0 A;  1TCO A;  5JJT A;  4FCX A;  1II7 A;  2ZBM A;  3H62 B;  3P71 C;  4DHL A;  4IL1 A;  1SU1 A;  2Z72 A;  4ZX2 A;  1MF8 A;  4LTY A;  2NYL C;  1QFC A;  4UT3 A;  3QFK A;  2QFR A;  4H1Y P;  3IVE A;  4M0V A;  5DNY A;  3DSD A;  1UF3 A;  4DSY A; 
#chains in the Genus database with same CATH homology
 3IB7 A;  2O8A A;  4TUI A;  4V0X A;  2ZO9 B;  4V0V A;  3D03 A;  2Z06 A;  2QFP A;  4JA7 A;  4UWQ A;  1Z2X A;  3H60 A;  1UTE A;  1NNW A;  3H68 A;  3HVQ A;  5F3W A;  2YEQ A;  2R17 A;  1OI8 A;  2NPP C;  1QHW A;  1M63 A;  5EQV A;  4FBK A;  4V0W A;  2NYM C;  3K7V C;  4H2G A;  2HYP A;  3QFO A;  4O43 A;  4H1S A;  3ICF A;  1T71 A;  5JPF A;  4H2F A;  3EGG A;  1S70 A;  1XZW A;  2DXN A;  4F0Z A;  2IE4 C;  4LAC C;  4IYP C;  1OID A;  2HY1 A;  2HYO A;  2WDF A;  4H2I A;  4MOY A;  4I5L C;  2IE3 C;  4O5G A;  1S95 A;  1S8E A;  4NZV A;  2AHD A;  1U32 A;  4G9J A;  1JK7 A;  4B2O A;  4XPN A;  3E7A A;  1OIE A;  3H67 A;  1WAR A;  5C1V A;  3QFN A;  1KBP A;  3C9F A;  3H63 A;  1S3L A;  1V73 A;  4ZVZ A;  2JOG A;  2WDD A;  2Z1A A;  3QFM A;  4KBP A;  2P6B A;  3ZU0 A;  2DFJ A;  4ORB A;  1W24 A;  2BDX A;  2BQ8 X;  3DW8 C;  5INB A;  3RL5 A;  3THN A;  1G5B A;  1HPU A;  4UT3 B;  3IB8 A;  1S3N A;  2QJC A;  2USH A;  3KBP A;  3V4Y A;  3C5W C;  3DSC A;  2DXL A;  1S3M A;  3RL4 A;  2YVT A;  4TUG A;  2XMO A;  3RL3 A;  3PSN A;  4LU9 A;  3AV0 A;  3H69 A;  4MOV A;  3EGH A;  5B8I A;  3TGH A;  3LL8 A;  4WWL A;  3FGA C;  4ORC A;  2Q8U A;  2ZOA A;  3IVD A;  3QG5 C;  4Q7F A;  2O8G A;  5GTU A;  3RQZ A;  4O4K A;  4FBW A;  3THO B;  3N5U A;  4O24 A;  5HPE A;  4I5N C;  2GJU A;  1AUI A;  3CK2 A;  5J28 A;  4ORA A;  1T70 A;  4H2B A;  5IOH A;  3E0J A;  4KKZ A;  2KKN A;  3T1I A;  3E7B A;  2WDE A;  2IAE C;  3PSO A;  1Z2W A;  2CV9 A;  4J6O A;  2A22 A;  3H66 A;  1XM7 A;  3FLO A;  3H64 A;  1HO5 A;  3H61 A;  5JPE A;  4OR9 A;  1HP1 A;  2WDC A;  2BCD A;  3AUZ A;  3K7W C;  1USH A;  3GVE A;  4HD0 A;  3JYF A;  4JA9 A;  1WAO 1;  4DT2 A;  1FJM A;  1IT6 A;  2NXF A;  4UT2 A;  4FBQ A;  4YKE A;  3ZTV A;  4MP0 A;  1TCO A;  5JJT A;  4FCX A;  1II7 A;  2ZBM A;  3H62 B;  3P71 C;  4DHL A;  4IL1 A;  1SU1 A;  2Z72 A;  4ZX2 A;  1MF8 A;  4LTY A;  2NYL C;  1QFC A;  4UT3 A;  3QFK A;  2QFR A;  4H1Y P;  3IVE A;  4M0V A;  5DNY A;  3DSD A;  1UF3 A;  4DSY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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