2NYMC

Crystal structure of protein phosphatase 2a (pp2a) with c-terminus truncated catalytic subunit
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein phosphatase 2
total genus 88
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nymC00
4KBPA 2WDDA 4DSYA 2XMOA 4Q7FA 2WDEA 4LACC 2NYLC 5IOHA 1T70A 3K7VC 4TUGA 3V4YA 4FBKA 2A22A 3HVQA 4ORAA 2BQ8X 3GVEA 3JYFA 2YVTA 4I5NC 2JOGA 4LU9A 4IL1A 5HPEA 4OR9A 3AUZA 4O24A 3ZU0A 2HYPA 3DSDA 4F0ZA 1QHWA 4V0XA 4B2OA 1NNWA 2WDCA 3RL4A 3RL5A 4G9JA 1OIEA 3E7BA 2QJCA 2Z1AA 2ZBMA 1AUIA 5JJTA 5JPEA 4XPNA 3DSCA 2BCDA 3P71C 3PSNA 4O4KA 3EGHA 1Z2XA 4ZVZA 4YKEA 2O8AA 3QFKA 4KKZA 4DT2A 1S3LA 1M63A 2KKNA 1HP1A 2NXFA 3THNA 4H2IA 1UF3A 4HD0A 2WDFA 3ZTVA 3H66A 1XM7A 3H64A 4H2GA 1WAO1 4MOYA 2Z06A 3H68A 4O5GA 4TUIA 4DHLA 3H62B 1WARA 1HPUA 4H1SA 4H2BA 5GTUA 3QFOA 1UTEA 3K7WC 1MF8A 3AV0A 5INBA 3LL8A 3ICFA 3FGAC 3IVDA 3IB8A 4IYPC 2P6BA 2IAEC 4J6OA 4ORBA 4LTYA 3RQZA 2QFRA 1S95A 2IE3C 4V0WA 4FBQA 4JA9A 3CK2A 4MP0A 4UWQA 1USHA 5J28A 2QFPA 3C9FA 1TCOA 4ORCA 3KBPA 2NYMC 2AHDA 3RL3A 3H69A 2CV9A 2HY1A 4JA7A 5B8IA 3H61A 1SU1A 2IE4C 1II7A 2GJUA 2Q8UA 1XZWA 4UT3A 4NZVA 4O43A 1V73A 3H63A 2R17A 1FJMA 1T71A 3PSOA 3H67A 3N5UA 4H1YP 4UT2A 1S3MA 5JPFA 1QFCA 2BDXA 1JK7A 3THOB 3DW8C 3EGGA 1OIDA 5F3WA 4I5LC 5EQVA 1S3NA 3IB7A 1S8EA 1S70A 1HO5A 3QFNA 4FCXA 2USHA 3T1IA 1G5BA 5DNYA 4WWLA 3TGHA 4ZX2A 2DFJA 4UT3B 3QG5C 3H60A 4FBWA 5C1VA 2Z72A 4V0VA 1IT6A 1W24A 2NPPC 1Z2WA 4MOVA 4H2FA 3C5WC 1OI8A 3E7AA 1KBPA 3QFMA 1U32A 2HYOA 3IVEA 2O8GA 4M0VA
chains in the Genus database with same CATH superfamily
4KBPA 2WDDA 4DSYA 2XMOA 4Q7FA 2WDEA 4LACC 2NYLC 5IOHA 1T70A 3K7VC 4TUGA 3V4YA 4FBKA 2A22A 3HVQA 4ORAA 2BQ8X 3GVEA 3JYFA 2YVTA 4I5NC 2JOGA 4LU9A 4IL1A 5HPEA 4OR9A 3AUZA 4O24A 3ZU0A 2HYPA 3DSDA 4F0ZA 1QHWA 4V0XA 4B2OA 1NNWA 2WDCA 3RL4A 3RL5A 4G9JA 1OIEA 3E7BA 2QJCA 2Z1AA 2ZBMA 1AUIA 5JJTA 5JPEA 4XPNA 3DSCA 2BCDA 3P71C 3PSNA 4O4KA 3EGHA 1Z2XA 4ZVZA 4YKEA 2O8AA 3QFKA 4KKZA 4DT2A 1S3LA 1M63A 2KKNA 1HP1A 2NXFA 3THNA 4H2IA 1UF3A 2DXNA 4HD0A 2WDFA 3ZTVA 3H66A 1XM7A 3H64A 4H2GA 1WAO1 4MOYA 2Z06A 3H68A 4O5GA 4TUIA 4DHLA 3H62B 1WARA 1HPUA 4H1SA 4H2BA 5GTUA 3QFOA 1UTEA 3K7WC 1MF8A 3AV0A 5INBA 3LL8A 3D03A 3FGAC 3ICFA 2ZO9B 3IVDA 3IB8A 4IYPC 2P6BA 2IAEC 4J6OA 4ORBA 4LTYA 3RQZA 2QFRA 3E0JA 1S95A 2IE3C 4V0WA 4FBQA 4JA9A 3CK2A 4MP0A 4UWQA 1USHA 5J28A 2QFPA 3C9FA 1TCOA 4ORCA 3KBPA 2NYMC 2AHDA 3RL3A 3H69A 2CV9A 2HY1A 4JA7A 5B8IA 3H61A 1SU1A 2IE4C 1II7A 3FLOA 2GJUA 2Q8UA 1XZWA 4UT3A 4NZVA 4O43A 1V73A 3H63A 2R17A 1FJMA 1T71A 3PSOA 3H67A 3N5UA 4H1YP 4UT2A 1S3MA 5JPFA 1QFCA 2BDXA 1JK7A 3THOB 3DW8C 2YEQA 3EGGA 1OIDA 5F3WA 4I5LC 5EQVA 1S3NA 3IB7A 1S8EA 1S70A 1HO5A 3QFNA 4FCXA 2USHA 3T1IA 1G5BA 2ZOAA 5DNYA 4WWLA 3TGHA 4ZX2A 2DFJA 4UT3B 3QG5C 3H60A 4FBWA 5C1VA 2Z72A 4V0VA 1IT6A 1W24A 2NPPC 1Z2WA 4MOVA 4H2FA 3C5WC 1OI8A 3E7AA 1KBPA 3QFMA 1U32A 2HYOA 3IVEA 2DXLA 2O8GA 4M0VA
chains in the Genus database with same CATH topology
4KBPA 2WDDA 4DSYA 2XMOA 4Q7FA 2WDEA 4LACC 2NYLC 5IOHA 1T70A 3K7VC 4TUGA 3V4YA 4FBKA 2A22A 3HVQA 4ORAA 2BQ8X 3GVEA 3JYFA 2YVTA 4I5NC 2JOGA 4LU9A 4IL1A 5HPEA 4OR9A 3AUZA 4O24A 3ZU0A 2HYPA 3DSDA 4F0ZA 1QHWA 4V0XA 4B2OA 1NNWA 2WDCA 3RL4A 3RL5A 4G9JA 1OIEA 3E7BA 2QJCA 2Z1AA 2ZBMA 1AUIA 5JJTA 5JPEA 4XPNA 3DSCA 2BCDA 3P71C 3PSNA 4O4KA 3EGHA 1Z2XA 4ZVZA 4YKEA 2O8AA 3QFKA 4KKZA 4DT2A 1S3LA 1M63A 2KKNA 1HP1A 2NXFA 3THNA 4H2IA 1UF3A 2DXNA 4HD0A 2WDFA 3ZTVA 3H66A 1XM7A 3H64A 4H2GA 1WAO1 4MOYA 2Z06A 3H68A 4O5GA 4TUIA 4DHLA 3H62B 1WARA 1HPUA 4H1SA 4H2BA 5GTUA 3QFOA 1UTEA 3K7WC 1MF8A 3AV0A 5INBA 3LL8A 3D03A 3FGAC 3ICFA 2ZO9B 3IVDA 3IB8A 4IYPC 2P6BA 2IAEC 4J6OA 4ORBA 4LTYA 3RQZA 2QFRA 3E0JA 1S95A 2IE3C 4V0WA 4FBQA 4JA9A 3CK2A 4MP0A 4UWQA 1USHA 5J28A 2QFPA 3C9FA 1TCOA 4ORCA 3KBPA 2NYMC 2AHDA 3RL3A 3H69A 2CV9A 2HY1A 4JA7A 5B8IA 3H61A 1SU1A 2IE4C 1II7A 3FLOA 2GJUA 2Q8UA 1XZWA 4UT3A 4NZVA 4O43A 1V73A 3H63A 2R17A 1FJMA 1T71A 3PSOA 3H67A 3N5UA 4H1YP 4UT2A 1S3MA 5JPFA 1QFCA 2BDXA 1JK7A 3THOB 3DW8C 2YEQA 3EGGA 1OIDA 5F3WA 4I5LC 5EQVA 1S3NA 3IB7A 1S8EA 1S70A 1HO5A 3QFNA 4FCXA 2USHA 3T1IA 1G5BA 2ZOAA 5DNYA 4WWLA 3TGHA 4ZX2A 2DFJA 4UT3B 3QG5C 3H60A 4FBWA 5C1VA 2Z72A 4V0VA 1IT6A 1W24A 2NPPC 1Z2WA 4MOVA 4H2FA 3C5WC 1OI8A 3E7AA 1KBPA 3QFMA 1U32A 2HYOA 3IVEA 2DXLA 2O8GA 4M0VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KBP A;  2WDD A;  4DSY A;  2XMO A;  4Q7F A;  2WDE A;  4LAC C;  2NYL C;  5IOH A;  1T70 A;  3K7V C;  4TUG A;  3V4Y A;  4FBK A;  2A22 A;  3HVQ A;  4ORA A;  2BQ8 X;  3GVE A;  3JYF A;  2YVT A;  4I5N C;  2JOG A;  4LU9 A;  4IL1 A;  5HPE A;  4OR9 A;  3AUZ A;  4O24 A;  3ZU0 A;  2HYP A;  3DSD A;  4F0Z A;  1QHW A;  4V0X A;  4B2O A;  1NNW A;  2WDC A;  3RL4 A;  3RL5 A;  4G9J A;  1OIE A;  3E7B A;  2QJC A;  2Z1A A;  2ZBM A;  1AUI A;  5JJT A;  5JPE A;  4XPN A;  3DSC A;  2BCD A;  3P71 C;  3PSN A;  4O4K A;  3EGH A;  1Z2X A;  4ZVZ A;  4YKE A;  2O8A A;  3QFK A;  4KKZ A;  4DT2 A;  1S3L A;  1M63 A;  2KKN A;  1HP1 A;  2NXF A;  3THN A;  4H2I A;  1UF3 A;  4HD0 A;  2WDF A;  3ZTV A;  3H66 A;  1XM7 A;  3H64 A;  4H2G A;  1WAO 1;  4MOY A;  2Z06 A;  3H68 A;  4O5G A;  4TUI A;  4DHL A;  3H62 B;  1WAR A;  1HPU A;  4H1S A;  4H2B A;  5GTU A;  3QFO A;  1UTE A;  3K7W C;  1MF8 A;  3AV0 A;  5INB A;  3LL8 A;  3ICF A;  3FGA C;  3IVD A;  3IB8 A;  4IYP C;  2P6B A;  2IAE C;  4J6O A;  4ORB A;  4LTY A;  3RQZ A;  2QFR A;  1S95 A;  2IE3 C;  4V0W A;  4FBQ A;  4JA9 A;  3CK2 A;  4MP0 A;  4UWQ A;  1USH A;  5J28 A;  2QFP A;  3C9F A;  1TCO A;  4ORC A;  3KBP A;  2NYM C;  2AHD A;  3RL3 A;  3H69 A;  2CV9 A;  2HY1 A;  4JA7 A;  5B8I A;  3H61 A;  1SU1 A;  2IE4 C;  1II7 A;  2GJU A;  2Q8U A;  1XZW A;  4UT3 A;  4NZV A;  4O43 A;  1V73 A;  3H63 A;  2R17 A;  1FJM A;  1T71 A;  3PSO A;  3H67 A;  3N5U A;  4H1Y P;  4UT2 A;  1S3M A;  5JPF A;  1QFC A;  2BDX A;  1JK7 A;  3THO B;  3DW8 C;  3EGG A;  1OID A;  5F3W A;  4I5L C;  5EQV A;  1S3N A;  3IB7 A;  1S8E A;  1S70 A;  1HO5 A;  3QFN A;  4FCX A;  2USH A;  3T1I A;  1G5B A;  5DNY A;  4WWL A;  3TGH A;  4ZX2 A;  2DFJ A;  4UT3 B;  3QG5 C;  3H60 A;  4FBW A;  5C1V A;  2Z72 A;  4V0V A;  1IT6 A;  1W24 A;  2NPP C;  1Z2W A;  4MOV A;  4H2F A;  3C5W C;  1OI8 A;  3E7A A;  1KBP A;  3QFM A;  1U32 A;  2HYO A;  3IVE A;  2O8G A;  4M0V A; 
#chains in the Genus database with same CATH topology
 4KBP A;  2WDD A;  4DSY A;  2XMO A;  4Q7F A;  2WDE A;  4LAC C;  2NYL C;  5IOH A;  1T70 A;  3K7V C;  4TUG A;  3V4Y A;  4FBK A;  2A22 A;  3HVQ A;  4ORA A;  2BQ8 X;  3GVE A;  3JYF A;  2YVT A;  4I5N C;  2JOG A;  4LU9 A;  4IL1 A;  5HPE A;  4OR9 A;  3AUZ A;  4O24 A;  3ZU0 A;  2HYP A;  3DSD A;  4F0Z A;  1QHW A;  4V0X A;  4B2O A;  1NNW A;  2WDC A;  3RL4 A;  3RL5 A;  4G9J A;  1OIE A;  3E7B A;  2QJC A;  2Z1A A;  2ZBM A;  1AUI A;  5JJT A;  5JPE A;  4XPN A;  3DSC A;  2BCD A;  3P71 C;  3PSN A;  4O4K A;  3EGH A;  1Z2X A;  4ZVZ A;  4YKE A;  2O8A A;  3QFK A;  4KKZ A;  4DT2 A;  1S3L A;  1M63 A;  2KKN A;  1HP1 A;  2NXF A;  3THN A;  4H2I A;  1UF3 A;  2DXN A;  4HD0 A;  2WDF A;  3ZTV A;  3H66 A;  1XM7 A;  3H64 A;  4H2G A;  1WAO 1;  4MOY A;  2Z06 A;  3H68 A;  4O5G A;  4TUI A;  4DHL A;  3H62 B;  1WAR A;  1HPU A;  4H1S A;  4H2B A;  5GTU A;  3QFO A;  1UTE A;  3K7W C;  1MF8 A;  3AV0 A;  5INB A;  3LL8 A;  3D03 A;  3FGA C;  3ICF A;  2ZO9 B;  3IVD A;  3IB8 A;  4IYP C;  2P6B A;  2IAE C;  4J6O A;  4ORB A;  4LTY A;  3RQZ A;  2QFR A;  3E0J A;  1S95 A;  2IE3 C;  4V0W A;  4FBQ A;  4JA9 A;  3CK2 A;  4MP0 A;  4UWQ A;  1USH A;  5J28 A;  2QFP A;  3C9F A;  1TCO A;  4ORC A;  3KBP A;  2NYM C;  2AHD A;  3RL3 A;  3H69 A;  2CV9 A;  2HY1 A;  4JA7 A;  5B8I A;  3H61 A;  1SU1 A;  2IE4 C;  1II7 A;  3FLO A;  2GJU A;  2Q8U A;  1XZW A;  4UT3 A;  4NZV A;  4O43 A;  1V73 A;  3H63 A;  2R17 A;  1FJM A;  1T71 A;  3PSO A;  3H67 A;  3N5U A;  4H1Y P;  4UT2 A;  1S3M A;  5JPF A;  1QFC A;  2BDX A;  1JK7 A;  3THO B;  3DW8 C;  2YEQ A;  3EGG A;  1OID A;  5F3W A;  4I5L C;  5EQV A;  1S3N A;  3IB7 A;  1S8E A;  1S70 A;  1HO5 A;  3QFN A;  4FCX A;  2USH A;  3T1I A;  1G5B A;  2ZOA A;  5DNY A;  4WWL A;  3TGH A;  4ZX2 A;  2DFJ A;  4UT3 B;  3QG5 C;  3H60 A;  4FBW A;  5C1V A;  2Z72 A;  4V0V A;  1IT6 A;  1W24 A;  2NPP C;  1Z2W A;  4MOV A;  4H2F A;  3C5W C;  1OI8 A;  3E7A A;  1KBP A;  3QFM A;  1U32 A;  2HYO A;  3IVE A;  2DXL A;  2O8G A;  4M0V A; 
#chains in the Genus database with same CATH homology
 4KBP A;  2WDD A;  4DSY A;  2XMO A;  4Q7F A;  2WDE A;  4LAC C;  2NYL C;  5IOH A;  1T70 A;  3K7V C;  4TUG A;  3V4Y A;  4FBK A;  2A22 A;  3HVQ A;  4ORA A;  2BQ8 X;  3GVE A;  3JYF A;  2YVT A;  4I5N C;  2JOG A;  4LU9 A;  4IL1 A;  5HPE A;  4OR9 A;  3AUZ A;  4O24 A;  3ZU0 A;  2HYP A;  3DSD A;  4F0Z A;  1QHW A;  4V0X A;  4B2O A;  1NNW A;  2WDC A;  3RL4 A;  3RL5 A;  4G9J A;  1OIE A;  3E7B A;  2QJC A;  2Z1A A;  2ZBM A;  1AUI A;  5JJT A;  5JPE A;  4XPN A;  3DSC A;  2BCD A;  3P71 C;  3PSN A;  4O4K A;  3EGH A;  1Z2X A;  4ZVZ A;  4YKE A;  2O8A A;  3QFK A;  4KKZ A;  4DT2 A;  1S3L A;  1M63 A;  2KKN A;  1HP1 A;  2NXF A;  3THN A;  4H2I A;  1UF3 A;  2DXN A;  4HD0 A;  2WDF A;  3ZTV A;  3H66 A;  1XM7 A;  3H64 A;  4H2G A;  1WAO 1;  4MOY A;  2Z06 A;  3H68 A;  4O5G A;  4TUI A;  4DHL A;  3H62 B;  1WAR A;  1HPU A;  4H1S A;  4H2B A;  5GTU A;  3QFO A;  1UTE A;  3K7W C;  1MF8 A;  3AV0 A;  5INB A;  3LL8 A;  3D03 A;  3FGA C;  3ICF A;  2ZO9 B;  3IVD A;  3IB8 A;  4IYP C;  2P6B A;  2IAE C;  4J6O A;  4ORB A;  4LTY A;  3RQZ A;  2QFR A;  3E0J A;  1S95 A;  2IE3 C;  4V0W A;  4FBQ A;  4JA9 A;  3CK2 A;  4MP0 A;  4UWQ A;  1USH A;  5J28 A;  2QFP A;  3C9F A;  1TCO A;  4ORC A;  3KBP A;  2NYM C;  2AHD A;  3RL3 A;  3H69 A;  2CV9 A;  2HY1 A;  4JA7 A;  5B8I A;  3H61 A;  1SU1 A;  2IE4 C;  1II7 A;  3FLO A;  2GJU A;  2Q8U A;  1XZW A;  4UT3 A;  4NZV A;  4O43 A;  1V73 A;  3H63 A;  2R17 A;  1FJM A;  1T71 A;  3PSO A;  3H67 A;  3N5U A;  4H1Y P;  4UT2 A;  1S3M A;  5JPF A;  1QFC A;  2BDX A;  1JK7 A;  3THO B;  3DW8 C;  2YEQ A;  3EGG A;  1OID A;  5F3W A;  4I5L C;  5EQV A;  1S3N A;  3IB7 A;  1S8E A;  1S70 A;  1HO5 A;  3QFN A;  4FCX A;  2USH A;  3T1I A;  1G5B A;  2ZOA A;  5DNY A;  4WWL A;  3TGH A;  4ZX2 A;  2DFJ A;  4UT3 B;  3QG5 C;  3H60 A;  4FBW A;  5C1V A;  2Z72 A;  4V0V A;  1IT6 A;  1W24 A;  2NPP C;  1Z2W A;  4MOV A;  4H2F A;  3C5W C;  1OI8 A;  3E7A A;  1KBP A;  3QFM A;  1U32 A;  2HYO A;  3IVE A;  2DXL A;  2O8G A;  4M0V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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