2P6BA

Crystal structure of human calcineurin in complex with pvivit peptide
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
357
structure length
357
Chain Sequence
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
pubmed doi rcsb
molecule tags Hydrolase/hydrolase regulator
source organism Homo sapiens
molecule keywords PVIVIT 14-mer Peptide
total genus 127
structure length 357
sequence length 357
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2007-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2p6bA00
4O5GA 1S70A 4IYPC 4V0XA 1WAO1 3LL8A 4LU9A 2WDDA 4KKZA 3H66A 3PSOA 4HD0A 2DFJA 3H60A 4UT3A 4O43A 5DNYA 1Z2XA 2BDXA 4O24A 4MOYA 3H63A 3AV0A 3JYFA 4TUGA 4UWQA 4H2GA 4XPNA 2BQ8X 3QFOA 2A22A 1T71A 4H2IA 5F3WA 1TCOA 1UF3A 3C5WC 1NNWA 3IVEA 1OI8A 3CK2A 1HPUA 1S95A 5J28A 2O8GA 4YKEA 3PSNA 3E7AA 3DW8C 4TUIA 2R17A 4FBQA 3H67A 1HO5A 4JA7A 4LTYA 2IAEC 4O4KA 1QHWA 1S8EA 1KBPA 3IVDA 3GVEA 4JA9A 4H1YP 4B2OA 2NXFA 1HP1A 4I5LC 4ZX2A 1W24A 2Z72A 3C9FA 3FGAC 1XZWA 3RL3A 4IL1A 1UTEA 4H2BA 1II7A 4UT2A 4UT3B 1U32A 3K7VC 5EQVA 2HYPA 4FCXA 3TGHA 4ORCA 4V0WA 2Z06A 3H69A 3EGGA 2NYMC 1S3MA 3EGHA 3H64A 4Q7FA 1XM7A 1OIDA 3RQZA 4ORBA 4DT2A 4KBPA 4MOVA 5C1VA 3IB7A 5JPFA 1IT6A 2YVTA 1JK7A 1T70A 3QFKA 4ZVZA 1AUIA 1MF8A 4H2FA 3V4YA 2AHDA 2USHA 2CV9A 3QG5C 3QFNA 5JJTA 2WDCA 1M63A 4FBKA 3THNA 4NZVA 1QFCA 1Z2WA 3AUZA 3H61A 3H68A 3ICFA 4ORAA 2JOGA 1FJMA 3DSDA 2Q8UA 3H62B 2QFPA 2O8AA 3RL4A 4FBWA 3IB8A 3E7BA 3K7WC 1SU1A 1G5BA 2QFRA 4I5NC 1USHA 4DHLA 4V0VA 3T1IA 5IOHA 5INBA 2NPPC 2NYLC 3QFMA 2WDEA 5GTUA 3ZTVA 4J6OA 2QJCA 3HVQA 4OR9A 4DSYA 2ZBMA 4H1SA 4M0VA 3ZU0A 4G9JA 2GJUA 2P6BA 3RL5A 2WDFA 2Z1AA 4F0ZA 3P71C 4LACC 4WWLA 3KBPA 5B8IA 4MP0A 5HPEA 2KKNA 5JPEA 1WARA 1OIEA 2BCDA 2IE3C 2HY1A 2XMOA 3THOB 2IE4C 3DSCA 1S3NA 1S3LA 1V73A 2HYOA 3N5UA
chains in the Genus database with same CATH superfamily
4O5GA 1S70A 4IYPC 4V0XA 1WAO1 3LL8A 4LU9A 2WDDA 4KKZA 3H66A 3PSOA 4HD0A 2DFJA 3H60A 4UT3A 4O43A 5DNYA 1Z2XA 2BDXA 4O24A 3FLOA 4MOYA 3H63A 3AV0A 3JYFA 4TUGA 4UWQA 4H2GA 3D03A 4XPNA 2BQ8X 3QFOA 2A22A 1T71A 4H2IA 5F3WA 1TCOA 1UF3A 3C5WC 1NNWA 3IVEA 1OI8A 3CK2A 1HPUA 1S95A 5J28A 2O8GA 4YKEA 3PSNA 3E7AA 3DW8C 4TUIA 2R17A 4FBQA 3H67A 1HO5A 4JA7A 4LTYA 2IAEC 4O4KA 1QHWA 1S8EA 1KBPA 3IVDA 3GVEA 4JA9A 4H1YP 4B2OA 2NXFA 1HP1A 4I5LC 4ZX2A 1W24A 2Z72A 3C9FA 3FGAC 1XZWA 3RL3A 4IL1A 1UTEA 4H2BA 1II7A 4UT2A 4UT3B 1U32A 3K7VC 5EQVA 2HYPA 4FCXA 3TGHA 4ORCA 4V0WA 2Z06A 3H69A 3EGGA 2NYMC 1S3MA 3EGHA 3H64A 2DXLA 4Q7FA 1XM7A 1OIDA 3RQZA 4ORBA 4DT2A 4KBPA 4MOVA 5C1VA 2DXNA 3IB7A 5JPFA 1IT6A 2YVTA 1JK7A 1T70A 3QFKA 4ZVZA 1AUIA 1MF8A 4H2FA 3V4YA 2AHDA 2USHA 2CV9A 3QG5C 3QFNA 5JJTA 2WDCA 1M63A 4FBKA 3THNA 4NZVA 1QFCA 1Z2WA 3AUZA 3H61A 3H68A 3ICFA 4ORAA 2JOGA 1FJMA 3DSDA 2Q8UA 3H62B 2QFPA 2O8AA 3RL4A 4FBWA 3IB8A 3E7BA 3K7WC 1SU1A 1G5BA 2QFRA 2YEQA 4I5NC 1USHA 4DHLA 4V0VA 3T1IA 5IOHA 5INBA 3E0JA 2NPPC 2NYLC 3QFMA 2WDEA 5GTUA 3ZTVA 4J6OA 2QJCA 3HVQA 4OR9A 4DSYA 2ZBMA 4H1SA 4M0VA 2ZOAA 3ZU0A 4G9JA 2GJUA 2P6BA 3RL5A 2WDFA 2Z1AA 4F0ZA 3P71C 4LACC 4WWLA 3KBPA 5B8IA 4MP0A 5HPEA 2KKNA 5JPEA 1WARA 1OIEA 2BCDA 2IE3C 2HY1A 2XMOA 3THOB 2IE4C 3DSCA 1S3NA 1S3LA 1V73A 2HYOA 2ZO9B 3N5UA
chains in the Genus database with same CATH topology
4O5GA 1S70A 4IYPC 4V0XA 1WAO1 3LL8A 4LU9A 2WDDA 4KKZA 3H66A 3PSOA 4HD0A 2DFJA 3H60A 4UT3A 4O43A 5DNYA 1Z2XA 2BDXA 4O24A 3FLOA 4MOYA 3H63A 3AV0A 3JYFA 4TUGA 4UWQA 4H2GA 3D03A 4XPNA 2BQ8X 3QFOA 2A22A 1T71A 4H2IA 5F3WA 1TCOA 1UF3A 3C5WC 1NNWA 3IVEA 1OI8A 3CK2A 1HPUA 1S95A 5J28A 2O8GA 4YKEA 3PSNA 3E7AA 3DW8C 4TUIA 2R17A 4FBQA 3H67A 1HO5A 4JA7A 4LTYA 2IAEC 4O4KA 1QHWA 1S8EA 1KBPA 3IVDA 3GVEA 4JA9A 4H1YP 4B2OA 2NXFA 1HP1A 4I5LC 4ZX2A 1W24A 2Z72A 3C9FA 3FGAC 1XZWA 3RL3A 4IL1A 1UTEA 4H2BA 1II7A 4UT2A 4UT3B 1U32A 3K7VC 5EQVA 2HYPA 4FCXA 3TGHA 4ORCA 4V0WA 2Z06A 3H69A 3EGGA 2NYMC 1S3MA 3EGHA 3H64A 2DXLA 4Q7FA 1XM7A 1OIDA 3RQZA 4ORBA 4DT2A 4KBPA 4MOVA 5C1VA 2DXNA 3IB7A 5JPFA 1IT6A 2YVTA 1JK7A 1T70A 3QFKA 4ZVZA 1AUIA 1MF8A 4H2FA 3V4YA 2AHDA 2USHA 2CV9A 3QG5C 3QFNA 5JJTA 2WDCA 1M63A 4FBKA 3THNA 4NZVA 1QFCA 1Z2WA 3AUZA 3H61A 3H68A 3ICFA 4ORAA 2JOGA 1FJMA 3DSDA 2Q8UA 3H62B 2QFPA 2O8AA 3RL4A 4FBWA 3IB8A 3E7BA 3K7WC 1SU1A 1G5BA 2QFRA 2YEQA 4I5NC 1USHA 4DHLA 4V0VA 3T1IA 5IOHA 5INBA 3E0JA 2NPPC 2NYLC 3QFMA 2WDEA 5GTUA 3ZTVA 4J6OA 2QJCA 3HVQA 4OR9A 4DSYA 2ZBMA 4H1SA 4M0VA 2ZOAA 3ZU0A 4G9JA 2GJUA 2P6BA 3RL5A 2WDFA 2Z1AA 4F0ZA 3P71C 4LACC 4WWLA 3KBPA 5B8IA 4MP0A 5HPEA 2KKNA 5JPEA 1WARA 1OIEA 2BCDA 2IE3C 2HY1A 2XMOA 3THOB 2IE4C 3DSCA 1S3NA 1S3LA 1V73A 2HYOA 2ZO9B 3N5UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O5G A;  1S70 A;  4IYP C;  4V0X A;  1WAO 1;  3LL8 A;  4LU9 A;  2WDD A;  4KKZ A;  3H66 A;  3PSO A;  4HD0 A;  2DFJ A;  3H60 A;  4UT3 A;  4O43 A;  5DNY A;  1Z2X A;  2BDX A;  4O24 A;  4MOY A;  3H63 A;  3AV0 A;  3JYF A;  4TUG A;  4UWQ A;  4H2G A;  4XPN A;  2BQ8 X;  3QFO A;  2A22 A;  1T71 A;  4H2I A;  5F3W A;  1TCO A;  1UF3 A;  3C5W C;  1NNW A;  3IVE A;  1OI8 A;  3CK2 A;  1HPU A;  1S95 A;  5J28 A;  2O8G A;  4YKE A;  3PSN A;  3E7A A;  3DW8 C;  4TUI A;  2R17 A;  4FBQ A;  3H67 A;  1HO5 A;  4JA7 A;  4LTY A;  2IAE C;  4O4K A;  1QHW A;  1S8E A;  1KBP A;  3IVD A;  3GVE A;  4JA9 A;  4H1Y P;  4B2O A;  2NXF A;  1HP1 A;  4I5L C;  4ZX2 A;  1W24 A;  2Z72 A;  3C9F A;  3FGA C;  1XZW A;  3RL3 A;  4IL1 A;  1UTE A;  4H2B A;  1II7 A;  4UT2 A;  4UT3 B;  1U32 A;  3K7V C;  5EQV A;  2HYP A;  4FCX A;  3TGH A;  4ORC A;  4V0W A;  2Z06 A;  3H69 A;  3EGG A;  2NYM C;  1S3M A;  3EGH A;  3H64 A;  4Q7F A;  1XM7 A;  1OID A;  3RQZ A;  4ORB A;  4DT2 A;  4KBP A;  4MOV A;  5C1V A;  3IB7 A;  5JPF A;  1IT6 A;  2YVT A;  1JK7 A;  1T70 A;  3QFK A;  4ZVZ A;  1AUI A;  1MF8 A;  4H2F A;  3V4Y A;  2AHD A;  2USH A;  2CV9 A;  3QG5 C;  3QFN A;  5JJT A;  2WDC A;  1M63 A;  4FBK A;  3THN A;  4NZV A;  1QFC A;  1Z2W A;  3AUZ A;  3H61 A;  3H68 A;  3ICF A;  4ORA A;  2JOG A;  1FJM A;  3DSD A;  2Q8U A;  3H62 B;  2QFP A;  2O8A A;  3RL4 A;  4FBW A;  3IB8 A;  3E7B A;  3K7W C;  1SU1 A;  1G5B A;  2QFR A;  4I5N C;  1USH A;  4DHL A;  4V0V A;  3T1I A;  5IOH A;  5INB A;  2NPP C;  2NYL C;  3QFM A;  2WDE A;  5GTU A;  3ZTV A;  4J6O A;  2QJC A;  3HVQ A;  4OR9 A;  4DSY A;  2ZBM A;  4H1S A;  4M0V A;  3ZU0 A;  4G9J A;  2GJU A;  2P6B A;  3RL5 A;  2WDF A;  2Z1A A;  4F0Z A;  3P71 C;  4LAC C;  4WWL A;  3KBP A;  5B8I A;  4MP0 A;  5HPE A;  2KKN A;  5JPE A;  1WAR A;  1OIE A;  2BCD A;  2IE3 C;  2HY1 A;  2XMO A;  3THO B;  2IE4 C;  3DSC A;  1S3N A;  1S3L A;  1V73 A;  2HYO A;  3N5U A; 
#chains in the Genus database with same CATH topology
 4O5G A;  1S70 A;  4IYP C;  4V0X A;  1WAO 1;  3LL8 A;  4LU9 A;  2WDD A;  4KKZ A;  3H66 A;  3PSO A;  4HD0 A;  2DFJ A;  3H60 A;  4UT3 A;  4O43 A;  5DNY A;  1Z2X A;  2BDX A;  4O24 A;  3FLO A;  4MOY A;  3H63 A;  3AV0 A;  3JYF A;  4TUG A;  4UWQ A;  4H2G A;  3D03 A;  4XPN A;  2BQ8 X;  3QFO A;  2A22 A;  1T71 A;  4H2I A;  5F3W A;  1TCO A;  1UF3 A;  3C5W C;  1NNW A;  3IVE A;  1OI8 A;  3CK2 A;  1HPU A;  1S95 A;  5J28 A;  2O8G A;  4YKE A;  3PSN A;  3E7A A;  3DW8 C;  4TUI A;  2R17 A;  4FBQ A;  3H67 A;  1HO5 A;  4JA7 A;  4LTY A;  2IAE C;  4O4K A;  1QHW A;  1S8E A;  1KBP A;  3IVD A;  3GVE A;  4JA9 A;  4H1Y P;  4B2O A;  2NXF A;  1HP1 A;  4I5L C;  4ZX2 A;  1W24 A;  2Z72 A;  3C9F A;  3FGA C;  1XZW A;  3RL3 A;  4IL1 A;  1UTE A;  4H2B A;  1II7 A;  4UT2 A;  4UT3 B;  1U32 A;  3K7V C;  5EQV A;  2HYP A;  4FCX A;  3TGH A;  4ORC A;  4V0W A;  2Z06 A;  3H69 A;  3EGG A;  2NYM C;  1S3M A;  3EGH A;  3H64 A;  2DXL A;  4Q7F A;  1XM7 A;  1OID A;  3RQZ A;  4ORB A;  4DT2 A;  4KBP A;  4MOV A;  5C1V A;  2DXN A;  3IB7 A;  5JPF A;  1IT6 A;  2YVT A;  1JK7 A;  1T70 A;  3QFK A;  4ZVZ A;  1AUI A;  1MF8 A;  4H2F A;  3V4Y A;  2AHD A;  2USH A;  2CV9 A;  3QG5 C;  3QFN A;  5JJT A;  2WDC A;  1M63 A;  4FBK A;  3THN A;  4NZV A;  1QFC A;  1Z2W A;  3AUZ A;  3H61 A;  3H68 A;  3ICF A;  4ORA A;  2JOG A;  1FJM A;  3DSD A;  2Q8U A;  3H62 B;  2QFP A;  2O8A A;  3RL4 A;  4FBW A;  3IB8 A;  3E7B A;  3K7W C;  1SU1 A;  1G5B A;  2QFR A;  2YEQ A;  4I5N C;  1USH A;  4DHL A;  4V0V A;  3T1I A;  5IOH A;  5INB A;  3E0J A;  2NPP C;  2NYL C;  3QFM A;  2WDE A;  5GTU A;  3ZTV A;  4J6O A;  2QJC A;  3HVQ A;  4OR9 A;  4DSY A;  2ZBM A;  4H1S A;  4M0V A;  2ZOA A;  3ZU0 A;  4G9J A;  2GJU A;  2P6B A;  3RL5 A;  2WDF A;  2Z1A A;  4F0Z A;  3P71 C;  4LAC C;  4WWL A;  3KBP A;  5B8I A;  4MP0 A;  5HPE A;  2KKN A;  5JPE A;  1WAR A;  1OIE A;  2BCD A;  2IE3 C;  2HY1 A;  2XMO A;  3THO B;  2IE4 C;  3DSC A;  1S3N A;  1S3L A;  1V73 A;  2HYO A;  2ZO9 B;  3N5U A; 
#chains in the Genus database with same CATH homology
 4O5G A;  1S70 A;  4IYP C;  4V0X A;  1WAO 1;  3LL8 A;  4LU9 A;  2WDD A;  4KKZ A;  3H66 A;  3PSO A;  4HD0 A;  2DFJ A;  3H60 A;  4UT3 A;  4O43 A;  5DNY A;  1Z2X A;  2BDX A;  4O24 A;  3FLO A;  4MOY A;  3H63 A;  3AV0 A;  3JYF A;  4TUG A;  4UWQ A;  4H2G A;  3D03 A;  4XPN A;  2BQ8 X;  3QFO A;  2A22 A;  1T71 A;  4H2I A;  5F3W A;  1TCO A;  1UF3 A;  3C5W C;  1NNW A;  3IVE A;  1OI8 A;  3CK2 A;  1HPU A;  1S95 A;  5J28 A;  2O8G A;  4YKE A;  3PSN A;  3E7A A;  3DW8 C;  4TUI A;  2R17 A;  4FBQ A;  3H67 A;  1HO5 A;  4JA7 A;  4LTY A;  2IAE C;  4O4K A;  1QHW A;  1S8E A;  1KBP A;  3IVD A;  3GVE A;  4JA9 A;  4H1Y P;  4B2O A;  2NXF A;  1HP1 A;  4I5L C;  4ZX2 A;  1W24 A;  2Z72 A;  3C9F A;  3FGA C;  1XZW A;  3RL3 A;  4IL1 A;  1UTE A;  4H2B A;  1II7 A;  4UT2 A;  4UT3 B;  1U32 A;  3K7V C;  5EQV A;  2HYP A;  4FCX A;  3TGH A;  4ORC A;  4V0W A;  2Z06 A;  3H69 A;  3EGG A;  2NYM C;  1S3M A;  3EGH A;  3H64 A;  2DXL A;  4Q7F A;  1XM7 A;  1OID A;  3RQZ A;  4ORB A;  4DT2 A;  4KBP A;  4MOV A;  5C1V A;  2DXN A;  3IB7 A;  5JPF A;  1IT6 A;  2YVT A;  1JK7 A;  1T70 A;  3QFK A;  4ZVZ A;  1AUI A;  1MF8 A;  4H2F A;  3V4Y A;  2AHD A;  2USH A;  2CV9 A;  3QG5 C;  3QFN A;  5JJT A;  2WDC A;  1M63 A;  4FBK A;  3THN A;  4NZV A;  1QFC A;  1Z2W A;  3AUZ A;  3H61 A;  3H68 A;  3ICF A;  4ORA A;  2JOG A;  1FJM A;  3DSD A;  2Q8U A;  3H62 B;  2QFP A;  2O8A A;  3RL4 A;  4FBW A;  3IB8 A;  3E7B A;  3K7W C;  1SU1 A;  1G5B A;  2QFR A;  2YEQ A;  4I5N C;  1USH A;  4DHL A;  4V0V A;  3T1I A;  5IOH A;  5INB A;  3E0J A;  2NPP C;  2NYL C;  3QFM A;  2WDE A;  5GTU A;  3ZTV A;  4J6O A;  2QJC A;  3HVQ A;  4OR9 A;  4DSY A;  2ZBM A;  4H1S A;  4M0V A;  2ZOA A;  3ZU0 A;  4G9J A;  2GJU A;  2P6B A;  3RL5 A;  2WDF A;  2Z1A A;  4F0Z A;  3P71 C;  4LAC C;  4WWL A;  3KBP A;  5B8I A;  4MP0 A;  5HPE A;  2KKN A;  5JPE A;  1WAR A;  1OIE A;  2BCD A;  2IE3 C;  2HY1 A;  2XMO A;  3THO B;  2IE4 C;  3DSC A;  1S3N A;  1S3L A;  1V73 A;  2HYO A;  2ZO9 B;  3N5U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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