2P6BA

Crystal structure of human calcineurin in complex with pvivit peptide
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
357
structure length
357
Chain Sequence
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase regulator
source organism Homo sapiens
publication title Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
pubmed doi rcsb
molecule keywords PVIVIT 14-mer Peptide
total genus 127
structure length 357
sequence length 357
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2007-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2p6bA00
2CV9A 2HY1A 4IYPC 3LL8A 4KBPA 4H2FA 1S70A 1S3LA 2P6BA 3H67A 4B2OA 4MOVA 1TCOA 4LACC 1S3NA 2YVTA 3H64A 3H69A 5JPEA 4UT3B 3DSCA 1HP1A 2QFRA 2XMOA 5C1VA 1IT6A 4H2IA 5J28A 3TGHA 2JOGA 3QFKA 1HPUA 1G5BA 3RL3A 3DSDA 2WDFA 4F0ZA 3PSOA 4V0WA 3N5UA 4XPNA 1SU1A 4ORBA 3QFNA 4JA9A 4FBWA 2Z06A 1QHWA 2BDXA 3K7WC 3C5WC 4NZVA 4O5GA 3EGHA 4OR9A 1V73A 2IE4C 3PSNA 5EQVA 4ORCA 1USHA 4TUGA 3ICFA 4H1SA 1T71A 2IAEC 3IB8A 4JA7A 4ZVZA 1QFCA 2A22A 1Z2WA 3H61A 1OI8A 1UTEA 2BQ8X 4DSYA 2Q8UA 3ZTVA 1FJMA 3GVEA 4H2BA 4O24A 2NYLC 2NPPC 3EGGA 3RQZA 4H1YP 2Z1AA 1XZWA 2IE3C 4V0XA 3JYFA 1UF3A 1AUIA 3AV0A 1XM7A 2WDDA 5IOHA 4LTYA 3QFOA 5HPEA 5F3WA 3HVQA 5GTUA 1U32A 4J6OA 3KBPA 1S95A 3H62B 1HO5A 1M63A 3H66A 1S3MA 2O8GA 1NNWA 4V0VA 3ZU0A 1S8EA 4UT3A 4KKZA 4DHLA 5JPFA 3IVDA 4FBQA 3H60A 3QG5C 3P71C 4H2GA 4I5NC 4YKEA 4Q7FA 3RL4A 2KKNA 3DW8C 4O4KA 2WDCA 3C9FA 3E7AA 3K7VC 4FCXA 1WARA 2QFPA 2HYPA 3THOB 3H68A 1KBPA 1OIEA 4ZX2A 3T1IA 4O43A 4IL1A 3E7BA 3QFMA 4LU9A 4UWQA 4MOYA 3H63A 1JK7A 1II7A 5B8IA 1MF8A 4TUIA 5DNYA 4FBKA 1WAO1 2GJUA 4G9JA 3CK2A 1Z2XA 4I5LC 3RL5A 3FGAC 2QJCA 3IB7A 4ORAA 2R17A 5INBA 2DFJA 2O8AA 2NYMC 2NXFA 5JJTA 3THNA 2AHDA 2WDEA 4DT2A 1OIDA 2USHA 4WWLA 3V4YA 2HYOA 4M0VA 1W24A 1T70A 2ZBMA 3IVEA 3AUZA 4UT2A 4HD0A 2BCDA 2Z72A 4MP0A
chains in the Genus database with same CATH superfamily
2CV9A 2HY1A 4IYPC 3LL8A 4KBPA 4H2FA 1S70A 1S3LA 2DXNA 2P6BA 3H67A 4B2OA 4MOVA 1TCOA 4LACC 1S3NA 2YVTA 3H64A 3H69A 5JPEA 4UT3B 3DSCA 1HP1A 2QFRA 2XMOA 5C1VA 1IT6A 4H2IA 5J28A 3TGHA 2JOGA 3QFKA 1HPUA 1G5BA 3RL3A 3DSDA 2WDFA 4F0ZA 3PSOA 4V0WA 3N5UA 4XPNA 1SU1A 4ORBA 3E0JA 3QFNA 4JA9A 4FBWA 2Z06A 3D03A 1QHWA 2BDXA 3K7WC 3C5WC 4NZVA 4O5GA 3EGHA 4OR9A 1V73A 2IE4C 3PSNA 5EQVA 4ORCA 1USHA 4TUGA 3ICFA 4H1SA 1T71A 2IAEC 3IB8A 4JA7A 4ZVZA 1QFCA 2A22A 1Z2WA 3H61A 1OI8A 1UTEA 2BQ8X 4DSYA 2Q8UA 3ZTVA 1FJMA 3GVEA 4H2BA 4O24A 2NYLC 2NPPC 3EGGA 3RQZA 4H1YP 2Z1AA 1XZWA 2IE3C 4V0XA 3JYFA 1UF3A 1AUIA 3AV0A 1XM7A 2WDDA 5IOHA 4LTYA 3QFOA 5HPEA 5F3WA 3HVQA 5GTUA 1U32A 4J6OA 3KBPA 2YEQA 1S95A 3H62B 1HO5A 1M63A 3H66A 1S3MA 2O8GA 1NNWA 4V0VA 2ZO9B 3ZU0A 1S8EA 4UT3A 4KKZA 2DXLA 4DHLA 5JPFA 3IVDA 4FBQA 3H60A 3QG5C 3P71C 4H2GA 4I5NC 4YKEA 4Q7FA 3RL4A 2KKNA 3DW8C 4O4KA 2WDCA 3C9FA 3E7AA 3K7VC 4FCXA 1WARA 2QFPA 2HYPA 3THOB 3H68A 1KBPA 1OIEA 4ZX2A 3T1IA 4O43A 2ZOAA 4IL1A 3E7BA 3QFMA 4LU9A 4UWQA 4MOYA 3H63A 1JK7A 1II7A 5B8IA 1MF8A 4TUIA 5DNYA 4FBKA 1WAO1 2GJUA 4G9JA 3CK2A 1Z2XA 4I5LC 3RL5A 3FGAC 2QJCA 3IB7A 4ORAA 2R17A 5INBA 2DFJA 2O8AA 2NYMC 2NXFA 5JJTA 3THNA 2AHDA 2WDEA 4DT2A 1OIDA 2USHA 4WWLA 3V4YA 2HYOA 4M0VA 1W24A 1T70A 2ZBMA 3IVEA 3AUZA 4UT2A 4HD0A 2BCDA 2Z72A 4MP0A 3FLOA
chains in the Genus database with same CATH topology
2CV9A 2HY1A 4IYPC 3LL8A 4KBPA 4H2FA 1S70A 1S3LA 2DXNA 2P6BA 3H67A 4B2OA 4MOVA 1TCOA 4LACC 1S3NA 2YVTA 3H64A 3H69A 5JPEA 4UT3B 3DSCA 1HP1A 2QFRA 2XMOA 5C1VA 1IT6A 4H2IA 5J28A 3TGHA 2JOGA 3QFKA 1HPUA 1G5BA 3RL3A 3DSDA 2WDFA 4F0ZA 3PSOA 4V0WA 3N5UA 4XPNA 1SU1A 4ORBA 3E0JA 3QFNA 4JA9A 4FBWA 2Z06A 3D03A 1QHWA 2BDXA 3K7WC 3C5WC 4NZVA 4O5GA 3EGHA 4OR9A 1V73A 2IE4C 3PSNA 5EQVA 4ORCA 1USHA 4TUGA 3ICFA 4H1SA 1T71A 2IAEC 3IB8A 4JA7A 4ZVZA 1QFCA 2A22A 1Z2WA 3H61A 1OI8A 1UTEA 2BQ8X 4DSYA 2Q8UA 3ZTVA 1FJMA 3GVEA 4H2BA 4O24A 2NYLC 2NPPC 3EGGA 3RQZA 4H1YP 2Z1AA 1XZWA 2IE3C 4V0XA 3JYFA 1UF3A 1AUIA 3AV0A 1XM7A 2WDDA 5IOHA 4LTYA 3QFOA 5HPEA 5F3WA 3HVQA 5GTUA 1U32A 4J6OA 3KBPA 2YEQA 1S95A 3H62B 1HO5A 1M63A 3H66A 1S3MA 2O8GA 1NNWA 4V0VA 2ZO9B 3ZU0A 1S8EA 4UT3A 4KKZA 2DXLA 4DHLA 5JPFA 3IVDA 4FBQA 3H60A 3QG5C 3P71C 4H2GA 4I5NC 4YKEA 4Q7FA 3RL4A 2KKNA 3DW8C 4O4KA 2WDCA 3C9FA 3E7AA 3K7VC 4FCXA 1WARA 2QFPA 2HYPA 3THOB 3H68A 1KBPA 1OIEA 4ZX2A 3T1IA 4O43A 2ZOAA 4IL1A 3E7BA 3QFMA 4LU9A 4UWQA 4MOYA 3H63A 1JK7A 1II7A 5B8IA 1MF8A 4TUIA 5DNYA 4FBKA 1WAO1 2GJUA 4G9JA 3CK2A 1Z2XA 4I5LC 3RL5A 3FGAC 2QJCA 3IB7A 4ORAA 2R17A 5INBA 2DFJA 2O8AA 2NYMC 2NXFA 5JJTA 3THNA 2AHDA 2WDEA 4DT2A 1OIDA 2USHA 4WWLA 3V4YA 2HYOA 4M0VA 1W24A 1T70A 2ZBMA 3IVEA 3AUZA 4UT2A 4HD0A 2BCDA 2Z72A 4MP0A 3FLOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CV9 A;  2HY1 A;  4IYP C;  3LL8 A;  4KBP A;  4H2F A;  1S70 A;  1S3L A;  2P6B A;  3H67 A;  4B2O A;  4MOV A;  1TCO A;  4LAC C;  1S3N A;  2YVT A;  3H64 A;  3H69 A;  5JPE A;  4UT3 B;  3DSC A;  1HP1 A;  2QFR A;  2XMO A;  5C1V A;  1IT6 A;  4H2I A;  5J28 A;  3TGH A;  2JOG A;  3QFK A;  1HPU A;  1G5B A;  3RL3 A;  3DSD A;  2WDF A;  4F0Z A;  3PSO A;  4V0W A;  3N5U A;  4XPN A;  1SU1 A;  4ORB A;  3QFN A;  4JA9 A;  4FBW A;  2Z06 A;  1QHW A;  2BDX A;  3K7W C;  3C5W C;  4NZV A;  4O5G A;  3EGH A;  4OR9 A;  1V73 A;  2IE4 C;  3PSN A;  5EQV A;  4ORC A;  1USH A;  4TUG A;  3ICF A;  4H1S A;  1T71 A;  2IAE C;  3IB8 A;  4JA7 A;  4ZVZ A;  1QFC A;  2A22 A;  1Z2W A;  3H61 A;  1OI8 A;  1UTE A;  2BQ8 X;  4DSY A;  2Q8U A;  3ZTV A;  1FJM A;  3GVE A;  4H2B A;  4O24 A;  2NYL C;  2NPP C;  3EGG A;  3RQZ A;  4H1Y P;  2Z1A A;  1XZW A;  2IE3 C;  4V0X A;  3JYF A;  1UF3 A;  1AUI A;  3AV0 A;  1XM7 A;  2WDD A;  5IOH A;  4LTY A;  3QFO A;  5HPE A;  5F3W A;  3HVQ A;  5GTU A;  1U32 A;  4J6O A;  3KBP A;  1S95 A;  3H62 B;  1HO5 A;  1M63 A;  3H66 A;  1S3M A;  2O8G A;  1NNW A;  4V0V A;  3ZU0 A;  1S8E A;  4UT3 A;  4KKZ A;  4DHL A;  5JPF A;  3IVD A;  4FBQ A;  3H60 A;  3QG5 C;  3P71 C;  4H2G A;  4I5N C;  4YKE A;  4Q7F A;  3RL4 A;  2KKN A;  3DW8 C;  4O4K A;  2WDC A;  3C9F A;  3E7A A;  3K7V C;  4FCX A;  1WAR A;  2QFP A;  2HYP A;  3THO B;  3H68 A;  1KBP A;  1OIE A;  4ZX2 A;  3T1I A;  4O43 A;  4IL1 A;  3E7B A;  3QFM A;  4LU9 A;  4UWQ A;  4MOY A;  3H63 A;  1JK7 A;  1II7 A;  5B8I A;  1MF8 A;  4TUI A;  5DNY A;  4FBK A;  1WAO 1;  2GJU A;  4G9J A;  3CK2 A;  1Z2X A;  4I5L C;  3RL5 A;  3FGA C;  2QJC A;  3IB7 A;  4ORA A;  2R17 A;  5INB A;  2DFJ A;  2O8A A;  2NYM C;  2NXF A;  5JJT A;  3THN A;  2AHD A;  2WDE A;  4DT2 A;  1OID A;  2USH A;  4WWL A;  3V4Y A;  2HYO A;  4M0V A;  1W24 A;  1T70 A;  2ZBM A;  3IVE A;  3AUZ A;  4UT2 A;  4HD0 A;  2BCD A;  2Z72 A;  4MP0 A; 
#chains in the Genus database with same CATH topology
 2CV9 A;  2HY1 A;  4IYP C;  3LL8 A;  4KBP A;  4H2F A;  1S70 A;  1S3L A;  2DXN A;  2P6B A;  3H67 A;  4B2O A;  4MOV A;  1TCO A;  4LAC C;  1S3N A;  2YVT A;  3H64 A;  3H69 A;  5JPE A;  4UT3 B;  3DSC A;  1HP1 A;  2QFR A;  2XMO A;  5C1V A;  1IT6 A;  4H2I A;  5J28 A;  3TGH A;  2JOG A;  3QFK A;  1HPU A;  1G5B A;  3RL3 A;  3DSD A;  2WDF A;  4F0Z A;  3PSO A;  4V0W A;  3N5U A;  4XPN A;  1SU1 A;  4ORB A;  3E0J A;  3QFN A;  4JA9 A;  4FBW A;  2Z06 A;  3D03 A;  1QHW A;  2BDX A;  3K7W C;  3C5W C;  4NZV A;  4O5G A;  3EGH A;  4OR9 A;  1V73 A;  2IE4 C;  3PSN A;  5EQV A;  4ORC A;  1USH A;  4TUG A;  3ICF A;  4H1S A;  1T71 A;  2IAE C;  3IB8 A;  4JA7 A;  4ZVZ A;  1QFC A;  2A22 A;  1Z2W A;  3H61 A;  1OI8 A;  1UTE A;  2BQ8 X;  4DSY A;  2Q8U A;  3ZTV A;  1FJM A;  3GVE A;  4H2B A;  4O24 A;  2NYL C;  2NPP C;  3EGG A;  3RQZ A;  4H1Y P;  2Z1A A;  1XZW A;  2IE3 C;  4V0X A;  3JYF A;  1UF3 A;  1AUI A;  3AV0 A;  1XM7 A;  2WDD A;  5IOH A;  4LTY A;  3QFO A;  5HPE A;  5F3W A;  3HVQ A;  5GTU A;  1U32 A;  4J6O A;  3KBP A;  2YEQ A;  1S95 A;  3H62 B;  1HO5 A;  1M63 A;  3H66 A;  1S3M A;  2O8G A;  1NNW A;  4V0V A;  2ZO9 B;  3ZU0 A;  1S8E A;  4UT3 A;  4KKZ A;  2DXL A;  4DHL A;  5JPF A;  3IVD A;  4FBQ A;  3H60 A;  3QG5 C;  3P71 C;  4H2G A;  4I5N C;  4YKE A;  4Q7F A;  3RL4 A;  2KKN A;  3DW8 C;  4O4K A;  2WDC A;  3C9F A;  3E7A A;  3K7V C;  4FCX A;  1WAR A;  2QFP A;  2HYP A;  3THO B;  3H68 A;  1KBP A;  1OIE A;  4ZX2 A;  3T1I A;  4O43 A;  2ZOA A;  4IL1 A;  3E7B A;  3QFM A;  4LU9 A;  4UWQ A;  4MOY A;  3H63 A;  1JK7 A;  1II7 A;  5B8I A;  1MF8 A;  4TUI A;  5DNY A;  4FBK A;  1WAO 1;  2GJU A;  4G9J A;  3CK2 A;  1Z2X A;  4I5L C;  3RL5 A;  3FGA C;  2QJC A;  3IB7 A;  4ORA A;  2R17 A;  5INB A;  2DFJ A;  2O8A A;  2NYM C;  2NXF A;  5JJT A;  3THN A;  2AHD A;  2WDE A;  4DT2 A;  1OID A;  2USH A;  4WWL A;  3V4Y A;  2HYO A;  4M0V A;  1W24 A;  1T70 A;  2ZBM A;  3IVE A;  3AUZ A;  4UT2 A;  4HD0 A;  2BCD A;  2Z72 A;  4MP0 A;  3FLO A; 
#chains in the Genus database with same CATH homology
 2CV9 A;  2HY1 A;  4IYP C;  3LL8 A;  4KBP A;  4H2F A;  1S70 A;  1S3L A;  2DXN A;  2P6B A;  3H67 A;  4B2O A;  4MOV A;  1TCO A;  4LAC C;  1S3N A;  2YVT A;  3H64 A;  3H69 A;  5JPE A;  4UT3 B;  3DSC A;  1HP1 A;  2QFR A;  2XMO A;  5C1V A;  1IT6 A;  4H2I A;  5J28 A;  3TGH A;  2JOG A;  3QFK A;  1HPU A;  1G5B A;  3RL3 A;  3DSD A;  2WDF A;  4F0Z A;  3PSO A;  4V0W A;  3N5U A;  4XPN A;  1SU1 A;  4ORB A;  3E0J A;  3QFN A;  4JA9 A;  4FBW A;  2Z06 A;  3D03 A;  1QHW A;  2BDX A;  3K7W C;  3C5W C;  4NZV A;  4O5G A;  3EGH A;  4OR9 A;  1V73 A;  2IE4 C;  3PSN A;  5EQV A;  4ORC A;  1USH A;  4TUG A;  3ICF A;  4H1S A;  1T71 A;  2IAE C;  3IB8 A;  4JA7 A;  4ZVZ A;  1QFC A;  2A22 A;  1Z2W A;  3H61 A;  1OI8 A;  1UTE A;  2BQ8 X;  4DSY A;  2Q8U A;  3ZTV A;  1FJM A;  3GVE A;  4H2B A;  4O24 A;  2NYL C;  2NPP C;  3EGG A;  3RQZ A;  4H1Y P;  2Z1A A;  1XZW A;  2IE3 C;  4V0X A;  3JYF A;  1UF3 A;  1AUI A;  3AV0 A;  1XM7 A;  2WDD A;  5IOH A;  4LTY A;  3QFO A;  5HPE A;  5F3W A;  3HVQ A;  5GTU A;  1U32 A;  4J6O A;  3KBP A;  2YEQ A;  1S95 A;  3H62 B;  1HO5 A;  1M63 A;  3H66 A;  1S3M A;  2O8G A;  1NNW A;  4V0V A;  2ZO9 B;  3ZU0 A;  1S8E A;  4UT3 A;  4KKZ A;  2DXL A;  4DHL A;  5JPF A;  3IVD A;  4FBQ A;  3H60 A;  3QG5 C;  3P71 C;  4H2G A;  4I5N C;  4YKE A;  4Q7F A;  3RL4 A;  2KKN A;  3DW8 C;  4O4K A;  2WDC A;  3C9F A;  3E7A A;  3K7V C;  4FCX A;  1WAR A;  2QFP A;  2HYP A;  3THO B;  3H68 A;  1KBP A;  1OIE A;  4ZX2 A;  3T1I A;  4O43 A;  2ZOA A;  4IL1 A;  3E7B A;  3QFM A;  4LU9 A;  4UWQ A;  4MOY A;  3H63 A;  1JK7 A;  1II7 A;  5B8I A;  1MF8 A;  4TUI A;  5DNY A;  4FBK A;  1WAO 1;  2GJU A;  4G9J A;  3CK2 A;  1Z2X A;  4I5L C;  3RL5 A;  3FGA C;  2QJC A;  3IB7 A;  4ORA A;  2R17 A;  5INB A;  2DFJ A;  2O8A A;  2NYM C;  2NXF A;  5JJT A;  3THN A;  2AHD A;  2WDE A;  4DT2 A;  1OID A;  2USH A;  4WWL A;  3V4Y A;  2HYO A;  4M0V A;  1W24 A;  1T70 A;  2ZBM A;  3IVE A;  3AUZ A;  4UT2 A;  4HD0 A;  2BCD A;  2Z72 A;  4MP0 A;  3FLO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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