2R7ZL

Cisplatin lesion containing rna polymerase ii elongation complex
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of transcriptional stalling at cisplatin-damaged DNA.
pubmed doi rcsb
molecule tags Transcription/dna-rna hybrid
molecule keywords 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3'
total genus 1
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2007-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 2r7zL00
1TWFL 3S1QL 1I50L 5IYBL 3CQZL 4AYBP 2E2IL 3HOUL 3GTQL 2YU9L 2JA6L 2R7ZL 3S14L 3H0GL 4C3HL 1TWHL 3HOWL 3S16L 4A3CL 5IP7L 5FLML 2JA7L 3M4OL 3H3VM 5IYCL 5IP9L 1TWGL 4X6AL 1Y1VL 3S1NL 2E2JL 4C3JL 3S1ML 4A3KL 4A3BL 4C3IL 3FKIL 2NVYL 5FJ8L 3S2HL 4BBSL 4Y7NL 4BBRL 1I3QL 1TWCL 5M5YL 4A3JL 3GTOL 3GTGL 2WAQP 3GTKL 3K7AL 1WCML 5M3FL 5C4XL 5M3ML 3S2DL 5M5XL 4A3ML 3I4NL 3GTJL 3HOXL 3S1RL 5M5WL 2NVXL 4A3EL 4QIWP 2NVTL 2PMZP 2R92L 1TWAL 5IYDL 3GTLL 3HOYL 4BY7L 2B63L 5C4JL 2VUML 3M3YL 5C44L 4A3IL 3S17L 1R9TL 3RZDL 2JA5L 2R93L 4BXXL 1K83L 2E2HL 4A3FL 3GTML 5C3EL 3RZOL 4Y52L 4BY1L 3HKZP 2WB1P 1SFOL 2JA8L 3HOVL 3PO2L 2Y0SP 4A93L 2NVQL 3I4ML 4A3DL 4A3GL 4C2M1 1Y1WL 3S15L 3GTPL 3PO3L 4A3LL 3HOZL 1I6HL
chains in the Genus database with same CATH superfamily
5RXNA 1VZGA 1NXGA 1R0FA 3LNLA 2JI2A 3GTQL 2ZIXA 3S14L 1BRFA 3H0GL 1TWHL 4E6YA 1B2OA 3S16L 2CR8A 3PL5A 5IP7L 5GAEc 3PWFA 5FLML 1PFVA 2XJTA 2XJPA 3KYUA 5IY0A 1Y1VL 5DM71 3KYXA 3SS2A 3S1ML 1BFYA 4C3IL 3RZTA 3S2HL 2PSMC 4V196 2Z3RB 1RDVA 3KYWA 1I3QL 3RZ6A 1LKOA 2LCQA 3PKJA 5GADc 3I4NL 3A44A 4QIWP 3LWOB 2C6AA 1LKMA 2PMZP 3B08B 4LHLA 3HOYL 2L0ZA 4A3IL 1JYBA 1YUXA 2PPTA 2JA5L 2Z3QB 5MFPA 1S30A 3PIP1 4AI3A 2MS3A 2CKAA 1PFYA 3B0AB 1RDGA 1Y1WL 2AUSB 4B8CD 4A3LL 3HOZL 2V3BB 3WWLA 4TVMA 3FDJA 2V0FA 3S1QL 1YK4A 5MGNA 2J9UB 4WFN1 2YU9L 1R0IA 2JA6L 2R7ZL 2M6OA 2QL0A 3RYGA 2K2DA 3KYYA 4A3CL 1FHHA 1SMUA 1P7PA 2B5ID 4POFA 2XJVA 4ME3A 1S24A 2E2JL 4G6BA 1T9OA 1QQTA 4A3BL 5AI3A 3P2AA 4Y7NL 5EIOC 2RFKB 3LWRB 2AQCA 5MFZA 4A3JL 4GS7D 1IROA 5M3FL 2JI1A 2M4YA 1BQ8A 3PZAA 4TPUA 3S2DL 2XJUA 5K2ME 2O5JD 1YV1A 1IU5A 1SMWA 5MLC3 4A3EL 3H9CA 1RYQA 4K9FA 3IU3I 2NVTL 1RB9A 1TWAL 4AHZA 3GTLL 1R0HA 4BY7L 3PKIA 2B63L 1DX8A 4ZN3B 4UY81 3H99A 5DM61 1Z92B 1S2ZA 3HJYB 3MQKB 4AI1A 4AI0A 2XJRA 2VL6A 1K83L 4A3FL 1WJVA 1IW7D 5C3EL 3LWPB 4RXNA 7RXNA 3HKZP 2WB1P 3PO2L 3MPSA 4XGHA 4A93L 1FHMA 1OWBA 3I4ML 4A3DL 5EINC 4C2M1 3S15L 3QVDA 3JR7A 1I6HL 1BQ9A 3VPBE 1TWFL 1IRNA 5IYBL 1BE7A 4AYBP 2E2IL 4JAGA 1B71A 2ERJA 4C3HL 2RDVA 3MSUA 4AR3A 2A6HD 4YWLA 1T9PA 2JA7L 1NNQA 1ODHA 3H3VM 5IYCL 5IP9L 1SMMA 3K35A 4LHNA 1TWGL 4X6AL 3S1NL 4C3JL 1PFWA 3HAXC 4A3KL 1C09A 3FKIL 1LKPA 5FJ8L 1RYTA 4BBRL 5MF6A 5JVG1 1YK5A 1PZXA 2KKDA 5M5YL 4YWMA 3NFPI 3GTGL 1YUZA 3GTKL 4XXBB 1VZHA 3K7AL 1WCML 5C4XL 5M3ML 2JI3A 1IU6A 4A3ML 3GTJL 1B13A 3HOXL 2A6ED 4AHWA 2NYDA 1VZIA 2VUML 2EY4E 8RXNA 5GAHc 1ZRPA 4AHYA 5AI2A 1CADA 1R9TL 4BXXL 2PVXA 3GTML 1E8JA 4BY1L 2JA8L 3HOVL 4AR5A 1NXEA 2PVEA 1T9QA 2NVQL 4AR6A 4A3GL 2APOB 2M6PA 3PIO1 1PFUA 1R0JA 1F4LA 1OWCA 1H7VA 1QYBA 2DSXA 1I50L 3QQCE 4AHXA 1DVBA 3CQZL 4JAEA 3HOUL 2KN9A 3HOWL 4AI2A 3M4OL 3P8BA 4JAFA 6RXNA 2A68D 4JADA 3LWQB 2HR5A 2ERSA 4ZN1B 2NVYL 3WWNB 3H9BA 4BBSL 2XJQA 1TWCL 2GMGA 2XJSA 4AR4A 1LTLA 3GTOL 2WAQP 3ZG6A 1R0GA 2A69D 5M5XL 5GAGc 3J7Z1 1CAAA 3HJWB 2M4VA 3S1RL 2H12A 5M5WL 2NVXL 2HVYC 1RWDA 2PYAA 5H1Sc 2R92L 5IYDL 5C4JL 3H97A 3LWVB 3M3YL 1VCXA 5AN9H 5C44L 3S17L 3J7Y1 5JVH1 3RZDL 2C6BA 2R93L 2E2HL 2AYJA 3RZOL 4Y52L 2V0EA 4U671 4POGA 1SFOL 1QCVA 2Y0SP 3KYVA 3LPEB 3GTPL 3PO3L 1B2JA 2BE5D 2CKCA
chains in the Genus database with same CATH topology
1TWFL 3S1QL 1I50L 5IYBL 3CQZL 4AYBP 2E2IL 3HOUL 3GTQL 2YU9L 2JA6L 2R7ZL 3S14L 3H0GL 4C3HL 1TWHL 3HOWL 3S16L 4A3CL 5IP7L 5FLML 2JA7L 3M4OL 3H3VM 5IYCL 5IP9L 1TWGL 4X6AL 1Y1VL 3S1NL 2E2JL 4C3JL 3S1ML 4A3KL 4A3BL 4C3IL 3FKIL 2NVYL 5FJ8L 3S2HL 4BBSL 4Y7NL 4BBRL 1I3QL 1TWCL 5M5YL 4A3JL 3GTOL 3GTGL 2WAQP 3GTKL 3K7AL 1WCML 5M3FL 5C4XL 5M3ML 3S2DL 5M5XL 4A3ML 3I4NL 3GTJL 3HOXL 3S1RL 5M5WL 2NVXL 4A3EL 4QIWP 2NVTL 2PMZP 2R92L 1TWAL 5IYDL 3GTLL 3HOYL 4BY7L 2B63L 5C4JL 2VUML 3M3YL 5C44L 4A3IL 3S17L 1R9TL 3RZDL 2JA5L 2R93L 4BXXL 1K83L 2E2HL 4A3FL 3GTML 5C3EL 3RZOL 4Y52L 4BY1L 3HKZP 2WB1P 1SFOL 2JA8L 3HOVL 3PO2L 2Y0SP 4A93L 2NVQL 3I4ML 4A3DL 4A3GL 4C2M1 1Y1WL 3S15L 3GTPL 3PO3L 4A3LL 3HOZL 1I6HL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TWF L;  3S1Q L;  1I50 L;  5IYB L;  3CQZ L;  4AYB P;  2E2I L;  3HOU L;  3GTQ L;  2YU9 L;  2JA6 L;  2R7Z L;  3S14 L;  3H0G L;  4C3H L;  1TWH L;  3HOW L;  3S16 L;  4A3C L;  5IP7 L;  5FLM L;  2JA7 L;  3M4O L;  3H3V M;  5IYC L;  5IP9 L;  1TWG L;  4X6A L;  1Y1V L;  3S1N L;  2E2J L;  4C3J L;  3S1M L;  4A3K L;  4A3B L;  4C3I L;  3FKI L;  2NVY L;  5FJ8 L;  3S2H L;  4BBS L;  4Y7N L;  4BBR L;  1I3Q L;  1TWC L;  5M5Y L;  4A3J L;  3GTO L;  3GTG L;  2WAQ P;  3GTK L;  3K7A L;  1WCM L;  5M3F L;  5C4X L;  5M3M L;  3S2D L;  5M5X L;  4A3M L;  3I4N L;  3GTJ L;  3HOX L;  3S1R L;  5M5W L;  2NVX L;  4A3E L;  4QIW P;  2NVT L;  2PMZ P;  2R92 L;  1TWA L;  5IYD L;  3GTL L;  3HOY L;  4BY7 L;  2B63 L;  5C4J L;  2VUM L;  3M3Y L;  5C44 L;  4A3I L;  3S17 L;  1R9T L;  3RZD L;  2JA5 L;  2R93 L;  4BXX L;  1K83 L;  2E2H L;  4A3F L;  3GTM L;  5C3E L;  3RZO L;  4Y52 L;  4BY1 L;  3HKZ P;  2WB1 P;  1SFO L;  2JA8 L;  3HOV L;  3PO2 L;  2Y0S P;  4A93 L;  2NVQ L;  3I4M L;  4A3D L;  4A3G L;  4C2M 1;  1Y1W L;  3S15 L;  3GTP L;  3PO3 L;  4A3L L;  3HOZ L;  1I6H L; 
#chains in the Genus database with same CATH topology
 5RXN A;  1VZG A;  1NXG A;  1R0F A;  3LNL A;  2JI2 A;  3GTQ L;  2ZIX A;  3S14 L;  1BRF A;  3H0G L;  1TWH L;  4E6Y A;  1B2O A;  3S16 L;  2CR8 A;  3PL5 A;  5IP7 L;  5GAE c;  3PWF A;  5FLM L;  1PFV A;  2XJT A;  2XJP A;  3KYU A;  5IY0 A;  1Y1V L;  5DM7 1;  3KYX A;  3SS2 A;  3S1M L;  1BFY A;  4C3I L;  3RZT A;  3S2H L;  2PSM C;  4V19 6;  2Z3R B;  1RDV A;  3KYW A;  1I3Q L;  3RZ6 A;  1LKO A;  2LCQ A;  3PKJ A;  5GAD c;  3I4N L;  3A44 A;  4QIW P;  3LWO B;  2C6A A;  1LKM A;  2PMZ P;  3B08 B;  4LHL A;  3HOY L;  2L0Z A;  4A3I L;  1JYB A;  1YUX A;  2PPT A;  2JA5 L;  2Z3Q B;  5MFP A;  1S30 A;  3PIP 1;  4AI3 A;  2MS3 A;  2CKA A;  1PFY A;  3B0A B;  1RDG A;  1Y1W L;  2AUS B;  4B8C D;  4A3L L;  3HOZ L;  2V3B B;  3WWL A;  4TVM A;  3FDJ A;  2V0F A;  3S1Q L;  1YK4 A;  5MGN A;  2J9U B;  4WFN 1;  2YU9 L;  1R0I A;  2JA6 L;  2R7Z L;  2M6O A;  2QL0 A;  3RYG A;  2K2D A;  3KYY A;  4A3C L;  1FHH A;  1SMU A;  1P7P A;  2B5I D;  4POF A;  2XJV A;  4ME3 A;  1S24 A;  2E2J L;  4G6B A;  1T9O A;  1QQT A;  4A3B L;  5AI3 A;  3P2A A;  4Y7N L;  5EIO C;  2RFK B;  3LWR B;  2AQC A;  5MFZ A;  4A3J L;  4GS7 D;  1IRO A;  5M3F L;  2JI1 A;  2M4Y A;  1BQ8 A;  3PZA A;  4TPU A;  3S2D L;  2XJU A;  5K2M E;  2O5J D;  1YV1 A;  1IU5 A;  1SMW A;  5MLC 3;  4A3E L;  3H9C A;  1RYQ A;  4K9F A;  3IU3 I;  2NVT L;  1RB9 A;  1TWA L;  4AHZ A;  3GTL L;  1R0H A;  4BY7 L;  3PKI A;  2B63 L;  1DX8 A;  4ZN3 B;  4UY8 1;  3H99 A;  5DM6 1;  1Z92 B;  1S2Z A;  3HJY B;  3MQK B;  4AI1 A;  4AI0 A;  2XJR A;  2VL6 A;  1K83 L;  4A3F L;  1WJV A;  1IW7 D;  5C3E L;  3LWP B;  4RXN A;  7RXN A;  3HKZ P;  2WB1 P;  3PO2 L;  3MPS A;  4XGH A;  4A93 L;  1FHM A;  1OWB A;  3I4M L;  4A3D L;  5EIN C;  4C2M 1;  3S15 L;  3QVD A;  3JR7 A;  1I6H L;  1BQ9 A;  3VPB E;  1TWF L;  1IRN A;  5IYB L;  1BE7 A;  4AYB P;  2E2I L;  4JAG A;  1B71 A;  2ERJ A;  4C3H L;  2RDV A;  3MSU A;  4AR3 A;  2A6H D;  4YWL A;  1T9P A;  2JA7 L;  1NNQ A;  1ODH A;  3H3V M;  5IYC L;  5IP9 L;  1SMM A;  3K35 A;  4LHN A;  1TWG L;  4X6A L;  3S1N L;  4C3J L;  1PFW A;  3HAX C;  4A3K L;  1C09 A;  3FKI L;  1LKP A;  5FJ8 L;  1RYT A;  4BBR L;  5MF6 A;  5JVG 1;  1YK5 A;  1PZX A;  2KKD A;  5M5Y L;  4YWM A;  3NFP I;  3GTG L;  1YUZ A;  3GTK L;  4XXB B;  1VZH A;  3K7A L;  1WCM L;  5C4X L;  5M3M L;  2JI3 A;  1IU6 A;  4A3M L;  3GTJ L;  1B13 A;  3HOX L;  2A6E D;  4AHW A;  2NYD A;  1VZI A;  2VUM L;  2EY4 E;  8RXN A;  5GAH c;  1ZRP A;  4AHY A;  5AI2 A;  1CAD A;  1R9T L;  4BXX L;  2PVX A;  3GTM L;  1E8J A;  4BY1 L;  2JA8 L;  3HOV L;  4AR5 A;  1NXE A;  2PVE A;  1T9Q A;  2NVQ L;  4AR6 A;  4A3G L;  2APO B;  2M6P A;  3PIO 1;  1PFU A;  1R0J A;  1F4L A;  1OWC A;  1H7V A;  1QYB A;  2DSX A;  1I50 L;  3QQC E;  4AHX A;  1DVB A;  3CQZ L;  4JAE A;  3HOU L;  2KN9 A;  3HOW L;  4AI2 A;  3M4O L;  3P8B A;  4JAF A;  6RXN A;  2A68 D;  4JAD A;  3LWQ B;  2HR5 A;  2ERS A;  4ZN1 B;  2NVY L;  3WWN B;  3H9B A;  4BBS L;  2XJQ A;  1TWC L;  2GMG A;  2XJS A;  4AR4 A;  1LTL A;  3GTO L;  2WAQ P;  3ZG6 A;  1R0G A;  2A69 D;  5M5X L;  5GAG c;  3J7Z 1;  1CAA A;  3HJW B;  2M4V A;  3S1R L;  2H12 A;  5M5W L;  2NVX L;  2HVY C;  1RWD A;  2PYA A;  5H1S c;  2R92 L;  5IYD L;  5C4J L;  3H97 A;  3LWV B;  3M3Y L;  1VCX A;  5AN9 H;  5C44 L;  3S17 L;  3J7Y 1;  5JVH 1;  3RZD L;  2C6B A;  2R93 L;  2E2H L;  2AYJ A;  3RZO L;  4Y52 L;  2V0E A;  4U67 1;  4POG A;  1SFO L;  1QCV A;  2Y0S P;  3KYV A;  3LPE B;  3GTP L;  3PO3 L;  1B2J A;  2BE5 D;  2CKC A; 
#chains in the Genus database with same CATH homology
 1TWF L;  3S1Q L;  1I50 L;  5IYB L;  3CQZ L;  4AYB P;  2E2I L;  3HOU L;  3GTQ L;  2YU9 L;  2JA6 L;  2R7Z L;  3S14 L;  3H0G L;  4C3H L;  1TWH L;  3HOW L;  3S16 L;  4A3C L;  5IP7 L;  5FLM L;  2JA7 L;  3M4O L;  3H3V M;  5IYC L;  5IP9 L;  1TWG L;  4X6A L;  1Y1V L;  3S1N L;  2E2J L;  4C3J L;  3S1M L;  4A3K L;  4A3B L;  4C3I L;  3FKI L;  2NVY L;  5FJ8 L;  3S2H L;  4BBS L;  4Y7N L;  4BBR L;  1I3Q L;  1TWC L;  5M5Y L;  4A3J L;  3GTO L;  3GTG L;  2WAQ P;  3GTK L;  3K7A L;  1WCM L;  5M3F L;  5C4X L;  5M3M L;  3S2D L;  5M5X L;  4A3M L;  3I4N L;  3GTJ L;  3HOX L;  3S1R L;  5M5W L;  2NVX L;  4A3E L;  4QIW P;  2NVT L;  2PMZ P;  2R92 L;  1TWA L;  5IYD L;  3GTL L;  3HOY L;  4BY7 L;  2B63 L;  5C4J L;  2VUM L;  3M3Y L;  5C44 L;  4A3I L;  3S17 L;  1R9T L;  3RZD L;  2JA5 L;  2R93 L;  4BXX L;  1K83 L;  2E2H L;  4A3F L;  3GTM L;  5C3E L;  3RZO L;  4Y52 L;  4BY1 L;  3HKZ P;  2WB1 P;  1SFO L;  2JA8 L;  3HOV L;  3PO2 L;  2Y0S P;  4A93 L;  2NVQ L;  3I4M L;  4A3D L;  4A3G L;  4C2M 1;  1Y1W L;  3S15 L;  3GTP L;  3PO3 L;  4A3L L;  3HOZ L;  1I6H L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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