2E2HL

Rna polymerase ii elongation complex at 5 mm mg2+ with gtp
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
pubmed doi rcsb
molecule tags Transcription,transferase/dna-rna hybrid
molecule keywords 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3'
total genus 2
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2006-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 2e2hL00
5M5XL 5M5YL 3M3YL 4Y7NL 4BXXL 5IP9L 3S1NL 1Y1WL 5IYCL 2Y0SP 2NVTL 4A93L 2JA8L 2R93L 3HOZL 3K7AL 3HOUL 3S2DL 2NVQL 2E2HL 4Y52L 5C44L 3PO2L 3H0GL 4BY1L 4A3ML 3CQZL 4A3CL 5C3EL 1R9TL 4C3HL 2PMZP 3S17L 3RZDL 3HKZP 5M5WL 1I3QL 4A3JL 4C3JL 2B63L 3GTML 3HOYL 4A3LL 3GTLL 4BBSL 4BY7L 2NVYL 2WB1P 3S16L 2JA5L 4QIWP 1TWHL 2WAQP 4A3EL 3S1ML 3I4ML 3GTJL 1K83L 1TWCL 5FLML 3S2HL 3GTQL 3GTOL 5C4XL 5M3FL 4A3FL 5C4JL 4X6AL 1Y1VL 4AYBP 5IP7L 3GTKL 2JA6L 3HOXL 3HOWL 4A3BL 4A3IL 3S1RL 3H3VM 3S1QL 1WCML 5M3ML 3HOVL 4A3DL 1SFOL 4BBRL 2JA7L 3RZOL 5IYBL 3M4OL 1TWAL 4C2M1 3PO3L 5FJ8L 2NVXL 2E2IL 2VUML 3GTGL 2YU9L 2R7ZL 3FKIL 3I4NL 4A3KL 4A3GL 3GTPL 2E2JL 2R92L 1TWFL 3S14L 3S15L 5IYDL 4C3IL 1TWGL 1I6HL 1I50L
chains in the Genus database with same CATH superfamily
5M5XL 5M5YL 2V0FA 4Y7NL 4BXXL 4JADA 5IYCL 4AR3A 4Y52L 2NYDA 1PZXA 4A3ML 4C3HL 2PMZP 3LPEB 3S17L 2GMGA 1R0GA 2A6HD 2JI1A 2XJRA 2XJPA 2B63L 2A69D 4POFA 4AHWA 2PVEA 3P2AA 3GTLL 4BBSL 2WB1P 1SMUA 3VPBE 2J9UB 5JVH1 1PFYA 1TWHL 5JVG1 3S1ML 1OWCA 3K35A 3MPSA 3B08B 3S2HL 1RWDA 5MFPA 1LKMA 5C4XL 5M3FL 1H7VA 2BE5D 3J7Y1 2MS3A 3S1RL 1WCML 3IU3I 3M4OL 3HAXC 2HVYC 1C09A 5EINC 4YWLA 5RXNA 2V0EA 3NFPI 1F4LA 2AUSB 2L0ZA 5GAEc 1LKOA 5IYDL 1IW7D 1S24A 1TWGL 1I6HL 2QL0A 1VZIA 5GADc 3ZG6A 4AI2A 3M3YL 5K2ME 2LCQA 5MF6A 1BRFA 2APOB 1Y1WL 1R0IA 4A93L 1FHMA 2JA8L 1IRNA 3K7AL 3S2DL 4ZN1B 4AR6A 1B2JA 2XJVA 3MSUA 5C44L 1CADA 2PPTA 3H0GL 4BY1L 2RFKB 4A3CL 3SS2A 2B5ID 3PKJA 3RZTA 1R9TL 1DX8A 4B8CD 1YV1A 3RZDL 1PFVA 5AN9H 3LWQB 3FDJA 2CR8A 4A3LL 2PVXA 2NVYL 3S16L 1IU6A 4QIWP 1LTLA 3KYVA 4RXNA 1S2ZA 5MGNA 2DSXA 1SMMA 3I4ML 3GTJL 1QQTA 5EIOC 2XJTA 4AI0A 4ME3A 3KYWA 4A3FL 1B2OA 1Y1VL 1VZHA 2CKAA 2M4YA 3GTKL 1RDVA 1T9OA 4A3BL 4WFN1 1R0FA 3H3VM 3J7Z1 5AI2A 4BBRL 4AHXA 3P8BA 3H99A 3PO3L 5FJ8L 2E2IL 5GAHc 1PFWA 3GTGL 3MQKB 2R7ZL 4AI1A 2KKDA 4JAGA 4A3KL 4A3GL 5GAGc 1S30A 4POGA 4BY7L 2CKCA 1BE7A 3LWOB 1R0JA 1SMWA 1YK5A 3S1NL 2NVTL 2V3BB 2A6ED 2R93L 3HOZL 3HOUL 3QQCE 2NVQL 4E6YA 2E2HL 1LKPA 4LHLA 2XJSA 3PL5A 3A44A 3HJYB 1BQ8A 5C3EL 4TPUA 1YUXA 2JI3A 4AI3A 7RXNA 1I3QL 2JI2A 3PWFA 4GS7D 1NXEA 4XXBB 2VL6A 2K2DA 4TVMA 5DM61 3RYGA 1JYBA 4A3EL 3RZ6A 2H12A 1TWCL 1NNQA 2EY4E 4XGHA 1QYBA 3GTQL 1RB9A 3H97A 5IY0A 2ERJA 1T9QA 1RDGA 4X6AL 4AR5A 2M6OA 4AYBP 2JA6L 3HOXL 2AYJA 3S1QL 3HOVL 5M3ML 1SFOL 3KYXA 1TWAL 3PZAA 4AHZA 1QCVA 3WWNB 4C2M1 5MFZA 1P7PA 3LWRB 3I4NL 3GTPL 1DVBA 2O5JD 2RDVA 4U671 3QVDA 1YUZA 5AI3A 5H1Sc 2ERSA 2M4VA 3KYUA 2ZIXA 2PYAA 5IP9L 1VZGA 1CAAA 1NXGA 2XJUA 2Y0SP 1ODHA 1R0HA 3H9BA 4JAEA 2PSMC 3LNLA 3PO2L 3CQZL 4AHYA 1E8JA 2AQCA 1T9PA 3JR7A 3HKZP 3PKIA 5M5WL 4A3JL 4C3JL 3GTML 2Z3RB 3HOYL 3B0AB 4YWMA 4JAFA 2JA5L 1RYQA 8RXNA 3LWVB 1Z92B 4ZN3B 1BFYA 2WAQP 6RXNA 4LHNA 5DM71 3LWPB 5MLC3 3PIP1 1K83L 1B71A 1YK4A 5FLML 3GTOL 1B13A 1IROA 1PFUA 1VCXA 1WJVA 5C4JL 4V196 5IP7L 2XJQA 3HJWB 3HOWL 2C6AA 3H9CA 4A3IL 1ZRPA 1IU5A 4A3DL 2JA7L 2C6BA 3PIO1 3RZOL 2KN9A 5IYBL 4AR4A 1BQ9A 2NVXL 2VUML 2HR5A 2YU9L 2M6PA 3FKIL 2Z3QB 4G6BA 1OWBA 2E2JL 2R92L 3KYYA 3WWLA 1TWFL 3S14L 3S15L 1FHHA 2A68D 4K9FA 4C3IL 1RYTA 1I50L 4UY81
chains in the Genus database with same CATH topology
5M5XL 5M5YL 3M3YL 4Y7NL 4BXXL 5IP9L 3S1NL 1Y1WL 5IYCL 2Y0SP 2NVTL 4A93L 2JA8L 2R93L 3HOZL 3K7AL 3HOUL 3S2DL 2NVQL 2E2HL 4Y52L 5C44L 3PO2L 3H0GL 4BY1L 4A3ML 3CQZL 4A3CL 5C3EL 1R9TL 4C3HL 2PMZP 3S17L 3RZDL 3HKZP 5M5WL 1I3QL 4A3JL 4C3JL 2B63L 3GTML 3HOYL 4A3LL 3GTLL 4BBSL 4BY7L 2NVYL 2WB1P 3S16L 2JA5L 4QIWP 1TWHL 2WAQP 4A3EL 3S1ML 3I4ML 3GTJL 1K83L 1TWCL 5FLML 3S2HL 3GTQL 3GTOL 5C4XL 5M3FL 4A3FL 5C4JL 4X6AL 1Y1VL 4AYBP 5IP7L 3GTKL 2JA6L 3HOXL 3HOWL 4A3BL 4A3IL 3S1RL 3H3VM 3S1QL 1WCML 5M3ML 3HOVL 4A3DL 1SFOL 4BBRL 2JA7L 3RZOL 5IYBL 3M4OL 1TWAL 4C2M1 3PO3L 5FJ8L 2NVXL 2E2IL 2VUML 3GTGL 2YU9L 2R7ZL 3FKIL 3I4NL 4A3KL 4A3GL 3GTPL 2E2JL 2R92L 1TWFL 3S14L 3S15L 5IYDL 4C3IL 1TWGL 1I6HL 1I50L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5M5X L;  5M5Y L;  3M3Y L;  4Y7N L;  4BXX L;  5IP9 L;  3S1N L;  1Y1W L;  5IYC L;  2Y0S P;  2NVT L;  4A93 L;  2JA8 L;  2R93 L;  3HOZ L;  3K7A L;  3HOU L;  3S2D L;  2NVQ L;  2E2H L;  4Y52 L;  5C44 L;  3PO2 L;  3H0G L;  4BY1 L;  4A3M L;  3CQZ L;  4A3C L;  5C3E L;  1R9T L;  4C3H L;  2PMZ P;  3S17 L;  3RZD L;  3HKZ P;  5M5W L;  1I3Q L;  4A3J L;  4C3J L;  2B63 L;  3GTM L;  3HOY L;  4A3L L;  3GTL L;  4BBS L;  4BY7 L;  2NVY L;  2WB1 P;  3S16 L;  2JA5 L;  4QIW P;  1TWH L;  2WAQ P;  4A3E L;  3S1M L;  3I4M L;  3GTJ L;  1K83 L;  1TWC L;  5FLM L;  3S2H L;  3GTQ L;  3GTO L;  5C4X L;  5M3F L;  4A3F L;  5C4J L;  4X6A L;  1Y1V L;  4AYB P;  5IP7 L;  3GTK L;  2JA6 L;  3HOX L;  3HOW L;  4A3B L;  4A3I L;  3S1R L;  3H3V M;  3S1Q L;  1WCM L;  5M3M L;  3HOV L;  4A3D L;  1SFO L;  4BBR L;  2JA7 L;  3RZO L;  5IYB L;  3M4O L;  1TWA L;  4C2M 1;  3PO3 L;  5FJ8 L;  2NVX L;  2E2I L;  2VUM L;  3GTG L;  2YU9 L;  2R7Z L;  3FKI L;  3I4N L;  4A3K L;  4A3G L;  3GTP L;  2E2J L;  2R92 L;  1TWF L;  3S14 L;  3S15 L;  5IYD L;  4C3I L;  1TWG L;  1I6H L;  1I50 L; 
#chains in the Genus database with same CATH topology
 5M5X L;  5M5Y L;  2V0F A;  4Y7N L;  4BXX L;  4JAD A;  5IYC L;  4AR3 A;  4Y52 L;  2NYD A;  1PZX A;  4A3M L;  4C3H L;  2PMZ P;  3LPE B;  3S17 L;  2GMG A;  1R0G A;  2A6H D;  2JI1 A;  2XJR A;  2XJP A;  2B63 L;  2A69 D;  4POF A;  4AHW A;  2PVE A;  3P2A A;  3GTL L;  4BBS L;  2WB1 P;  1SMU A;  3VPB E;  2J9U B;  5JVH 1;  1PFY A;  1TWH L;  5JVG 1;  3S1M L;  1OWC A;  3K35 A;  3MPS A;  3B08 B;  3S2H L;  1RWD A;  5MFP A;  1LKM A;  5C4X L;  5M3F L;  1H7V A;  2BE5 D;  3J7Y 1;  2MS3 A;  3S1R L;  1WCM L;  3IU3 I;  3M4O L;  3HAX C;  2HVY C;  1C09 A;  5EIN C;  4YWL A;  5RXN A;  2V0E A;  3NFP I;  1F4L A;  2AUS B;  2L0Z A;  5GAE c;  1LKO A;  5IYD L;  1IW7 D;  1S24 A;  1TWG L;  1I6H L;  2QL0 A;  1VZI A;  5GAD c;  3ZG6 A;  4AI2 A;  3M3Y L;  5K2M E;  2LCQ A;  5MF6 A;  1BRF A;  2APO B;  1Y1W L;  1R0I A;  4A93 L;  1FHM A;  2JA8 L;  1IRN A;  3K7A L;  3S2D L;  4ZN1 B;  4AR6 A;  1B2J A;  2XJV A;  3MSU A;  5C44 L;  1CAD A;  2PPT A;  3H0G L;  4BY1 L;  2RFK B;  4A3C L;  3SS2 A;  2B5I D;  3PKJ A;  3RZT A;  1R9T L;  1DX8 A;  4B8C D;  1YV1 A;  3RZD L;  1PFV A;  5AN9 H;  3LWQ B;  3FDJ A;  2CR8 A;  4A3L L;  2PVX A;  2NVY L;  3S16 L;  1IU6 A;  4QIW P;  1LTL A;  3KYV A;  4RXN A;  1S2Z A;  5MGN A;  2DSX A;  1SMM A;  3I4M L;  3GTJ L;  1QQT A;  5EIO C;  2XJT A;  4AI0 A;  4ME3 A;  3KYW A;  4A3F L;  1B2O A;  1Y1V L;  1VZH A;  2CKA A;  2M4Y A;  3GTK L;  1RDV A;  1T9O A;  4A3B L;  4WFN 1;  1R0F A;  3H3V M;  3J7Z 1;  5AI2 A;  4BBR L;  4AHX A;  3P8B A;  3H99 A;  3PO3 L;  5FJ8 L;  2E2I L;  5GAH c;  1PFW A;  3GTG L;  3MQK B;  2R7Z L;  4AI1 A;  2KKD A;  4JAG A;  4A3K L;  4A3G L;  5GAG c;  1S30 A;  4POG A;  4BY7 L;  2CKC A;  1BE7 A;  3LWO B;  1R0J A;  1SMW A;  1YK5 A;  3S1N L;  2NVT L;  2V3B B;  2A6E D;  2R93 L;  3HOZ L;  3HOU L;  3QQC E;  2NVQ L;  4E6Y A;  2E2H L;  1LKP A;  4LHL A;  2XJS A;  3PL5 A;  3A44 A;  3HJY B;  1BQ8 A;  5C3E L;  4TPU A;  1YUX A;  2JI3 A;  4AI3 A;  7RXN A;  1I3Q L;  2JI2 A;  3PWF A;  4GS7 D;  1NXE A;  4XXB B;  2VL6 A;  2K2D A;  4TVM A;  5DM6 1;  3RYG A;  1JYB A;  4A3E L;  3RZ6 A;  2H12 A;  1TWC L;  1NNQ A;  2EY4 E;  4XGH A;  1QYB A;  3GTQ L;  1RB9 A;  3H97 A;  5IY0 A;  2ERJ A;  1T9Q A;  1RDG A;  4X6A L;  4AR5 A;  2M6O A;  4AYB P;  2JA6 L;  3HOX L;  2AYJ A;  3S1Q L;  3HOV L;  5M3M L;  1SFO L;  3KYX A;  1TWA L;  3PZA A;  4AHZ A;  1QCV A;  3WWN B;  4C2M 1;  5MFZ A;  1P7P A;  3LWR B;  3I4N L;  3GTP L;  1DVB A;  2O5J D;  2RDV A;  4U67 1;  3QVD A;  1YUZ A;  5AI3 A;  5H1S c;  2ERS A;  2M4V A;  3KYU A;  2ZIX A;  2PYA A;  5IP9 L;  1VZG A;  1CAA A;  1NXG A;  2XJU A;  2Y0S P;  1ODH A;  1R0H A;  3H9B A;  4JAE A;  2PSM C;  3LNL A;  3PO2 L;  3CQZ L;  4AHY A;  1E8J A;  2AQC A;  1T9P A;  3JR7 A;  3HKZ P;  3PKI A;  5M5W L;  4A3J L;  4C3J L;  3GTM L;  2Z3R B;  3HOY L;  3B0A B;  4YWM A;  4JAF A;  2JA5 L;  1RYQ A;  8RXN A;  3LWV B;  1Z92 B;  4ZN3 B;  1BFY A;  2WAQ P;  6RXN A;  4LHN A;  5DM7 1;  3LWP B;  5MLC 3;  3PIP 1;  1K83 L;  1B71 A;  1YK4 A;  5FLM L;  3GTO L;  1B13 A;  1IRO A;  1PFU A;  1VCX A;  1WJV A;  5C4J L;  4V19 6;  5IP7 L;  2XJQ A;  3HJW B;  3HOW L;  2C6A A;  3H9C A;  4A3I L;  1ZRP A;  1IU5 A;  4A3D L;  2JA7 L;  2C6B A;  3PIO 1;  3RZO L;  2KN9 A;  5IYB L;  4AR4 A;  1BQ9 A;  2NVX L;  2VUM L;  2HR5 A;  2YU9 L;  2M6P A;  3FKI L;  2Z3Q B;  4G6B A;  1OWB A;  2E2J L;  2R92 L;  3KYY A;  3WWL A;  1TWF L;  3S14 L;  3S15 L;  1FHH A;  2A68 D;  4K9F A;  4C3I L;  1RYT A;  1I50 L;  4UY8 1; 
#chains in the Genus database with same CATH homology
 5M5X L;  5M5Y L;  3M3Y L;  4Y7N L;  4BXX L;  5IP9 L;  3S1N L;  1Y1W L;  5IYC L;  2Y0S P;  2NVT L;  4A93 L;  2JA8 L;  2R93 L;  3HOZ L;  3K7A L;  3HOU L;  3S2D L;  2NVQ L;  2E2H L;  4Y52 L;  5C44 L;  3PO2 L;  3H0G L;  4BY1 L;  4A3M L;  3CQZ L;  4A3C L;  5C3E L;  1R9T L;  4C3H L;  2PMZ P;  3S17 L;  3RZD L;  3HKZ P;  5M5W L;  1I3Q L;  4A3J L;  4C3J L;  2B63 L;  3GTM L;  3HOY L;  4A3L L;  3GTL L;  4BBS L;  4BY7 L;  2NVY L;  2WB1 P;  3S16 L;  2JA5 L;  4QIW P;  1TWH L;  2WAQ P;  4A3E L;  3S1M L;  3I4M L;  3GTJ L;  1K83 L;  1TWC L;  5FLM L;  3S2H L;  3GTQ L;  3GTO L;  5C4X L;  5M3F L;  4A3F L;  5C4J L;  4X6A L;  1Y1V L;  4AYB P;  5IP7 L;  3GTK L;  2JA6 L;  3HOX L;  3HOW L;  4A3B L;  4A3I L;  3S1R L;  3H3V M;  3S1Q L;  1WCM L;  5M3M L;  3HOV L;  4A3D L;  1SFO L;  4BBR L;  2JA7 L;  3RZO L;  5IYB L;  3M4O L;  1TWA L;  4C2M 1;  3PO3 L;  5FJ8 L;  2NVX L;  2E2I L;  2VUM L;  3GTG L;  2YU9 L;  2R7Z L;  3FKI L;  3I4N L;  4A3K L;  4A3G L;  3GTP L;  2E2J L;  2R92 L;  1TWF L;  3S14 L;  3S15 L;  5IYD L;  4C3I L;  1TWG L;  1I6H L;  1I50 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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