2HYPA

Crystal structure of rv0805 d66a mutant
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
256
structure length
230
Chain Sequence
PRPDYVLLHISDTHLIGGDDADDRLGELLEQLNQSGLRPDAIVFTGDLAAKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCGCNLVHVYPDTVVHSVIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
molecule keywords Hypothetical protein RV0805
total genus 69
structure length 230
sequence length 256
ec nomenclature ec 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2hypA00
3THOB 5DNYA 4MOYA 3DSCA 3RQZA 2JOGA 4H2GA 4FBKA 3ZTVA 4DSYA 4IYPC 4V0WA 1KBPA 4DT2A 1UTEA 3H69A 1M63A 2CV9A 2O8AA 4ORBA 4ZVZA 4MOVA 3EGGA 5INBA 1S3LA 2NYMC 1UF3A 2ZBMA 3QFOA 4ORCA 3RL3A 3IB8A 2USHA 4H2BA 4O24A 1G5BA 1S95A 3ICFA 4LU9A 1USHA 3QFKA 3PSOA 1QFCA 1IT6A 5JJTA 3H62B 3CK2A 4I5NC 3QG5C 1AUIA 4MP0A 1OIEA 3GVEA 3K7VC 4LTYA 4DHLA 2IAEC 1WAO1 1Z2WA 2HYPA 4KKZA 3EGHA 2WDCA 2HY1A 2NXFA 4LACC 1U32A 2WDFA 4G9JA 1W24A 3QFNA 1WARA 2HYOA 3H63A 4TUGA 2Q8UA 3RL5A 2BDXA 2A22A 4V0XA 1V73A 1OIDA 5JPEA 2BQ8X 5GTUA 4B2OA 4UT2A 4JA9A 1II7A 2NPPC 4OR9A 5C1VA 2R17A 3DW8C 5IOHA 1S3MA 1HP1A 1JK7A 3RL4A 4KBPA 1HPUA 4H1SA 4IL1A 4YKEA 3E7AA 3N5UA 4H1YP 4O4KA 3V4YA 4F0ZA 2P6BA 1XZWA 3H67A 1HO5A 4Q7FA 2WDDA 3H66A 2AHDA 3H61A 4FBQA 4HD0A 5F3WA 2DFJA 4FBWA 4UWQA 2YVTA 2IE3C 3K7WC 4I5LC 1OI8A 3IVEA 5J28A 3H64A 5JPFA 3P71C 1NNWA 3C5WC 1T70A 2O8GA 5HPEA 2KKNA 2Z1AA 3AV0A 4XPNA 2IE4C 2NYLC 1SU1A 2GJUA 3HVQA 2BCDA 3H68A 3DSDA 4UT3B 2QFPA 3QFMA 2Z06A 2Z72A 3C9FA 4M0VA 1TCOA 2XMOA 3TGHA 3IB7A 1FJMA 4ZX2A 3LL8A 3E7BA 4NZVA 1S70A 5B8IA 4JA7A 4FCXA 3THNA 1QHWA 1MF8A 1XM7A 2WDEA 3T1IA 1T71A 3AUZA 4ORAA 3JYFA 3KBPA 3PSNA 1S3NA 4H2IA 4UT3A 4TUIA 2QJCA 1S8EA 4O43A 3FGAC 4V0VA 2QFRA 3ZU0A 5EQVA 3H60A 4H2FA 4O5GA 1Z2XA 4J6OA 3IVDA 4WWLA
chains in the Genus database with same CATH superfamily
3THOB 5DNYA 4MOYA 3DSCA 3RQZA 2JOGA 4H2GA 4FBKA 3ZTVA 4DSYA 4IYPC 3FLOA 4V0WA 1KBPA 4DT2A 1UTEA 3H69A 1M63A 2CV9A 2O8AA 4ORBA 4ZVZA 4MOVA 3EGGA 5INBA 1S3LA 2NYMC 1UF3A 2ZBMA 3QFOA 4ORCA 3RL3A 3IB8A 2USHA 4H2BA 4O24A 1G5BA 1S95A 3ICFA 4LU9A 1USHA 3QFKA 3PSOA 1QFCA 1IT6A 5JJTA 3H62B 3CK2A 4I5NC 3QG5C 1AUIA 4MP0A 1OIEA 3GVEA 3K7VC 4LTYA 4DHLA 2IAEC 1WAO1 1Z2WA 2HYPA 4KKZA 3EGHA 2WDCA 2HY1A 2NXFA 4LACC 1U32A 2WDFA 2ZO9B 4G9JA 1W24A 3QFNA 1WARA 2HYOA 3H63A 4TUGA 2Q8UA 3E0JA 3RL5A 2BDXA 2A22A 4V0XA 1V73A 1OIDA 5JPEA 2BQ8X 5GTUA 4B2OA 4UT2A 4JA9A 1II7A 2NPPC 4OR9A 5C1VA 2R17A 3DW8C 5IOHA 2ZOAA 1S3MA 1HP1A 1JK7A 3RL4A 4KBPA 1HPUA 4H1SA 4IL1A 2YEQA 4YKEA 3E7AA 3N5UA 4H1YP 4O4KA 3V4YA 4F0ZA 2P6BA 1XZWA 3H67A 1HO5A 4Q7FA 2WDDA 3H66A 2AHDA 3H61A 4FBQA 4HD0A 5F3WA 2DFJA 4FBWA 4UWQA 2YVTA 2IE3C 3K7WC 4I5LC 1OI8A 3IVEA 5J28A 3H64A 5JPFA 3P71C 1NNWA 3C5WC 1T70A 2O8GA 5HPEA 2KKNA 2Z1AA 3AV0A 4XPNA 2IE4C 2NYLC 1SU1A 2GJUA 3HVQA 2BCDA 3H68A 3DSDA 4UT3B 2QFPA 3QFMA 2Z06A 2Z72A 3C9FA 4M0VA 1TCOA 2XMOA 3TGHA 3IB7A 1FJMA 4ZX2A 3LL8A 3E7BA 4NZVA 1S70A 5B8IA 2DXLA 4JA7A 4FCXA 3THNA 1QHWA 1MF8A 1XM7A 3D03A 2WDEA 3T1IA 1T71A 3AUZA 4ORAA 3JYFA 2DXNA 3KBPA 1S3NA 3PSNA 4H2IA 4UT3A 4TUIA 2QJCA 1S8EA 4O43A 3FGAC 4V0VA 2QFRA 3ZU0A 5EQVA 3H60A 4H2FA 4O5GA 1Z2XA 4J6OA 3IVDA 4WWLA
chains in the Genus database with same CATH topology
3THOB 5DNYA 4MOYA 3DSCA 3RQZA 2JOGA 4H2GA 4FBKA 3ZTVA 4DSYA 4IYPC 3FLOA 4V0WA 1KBPA 4DT2A 1UTEA 3H69A 1M63A 2CV9A 2O8AA 4ORBA 4ZVZA 4MOVA 3EGGA 5INBA 1S3LA 2NYMC 1UF3A 2ZBMA 3QFOA 4ORCA 3RL3A 3IB8A 2USHA 4H2BA 4O24A 1G5BA 1S95A 3ICFA 4LU9A 1USHA 3QFKA 3PSOA 1QFCA 1IT6A 5JJTA 3H62B 3CK2A 4I5NC 3QG5C 1AUIA 4MP0A 1OIEA 3GVEA 3K7VC 4LTYA 4DHLA 2IAEC 1WAO1 1Z2WA 2HYPA 4KKZA 3EGHA 2WDCA 2HY1A 2NXFA 4LACC 1U32A 2WDFA 2ZO9B 4G9JA 1W24A 3QFNA 1WARA 2HYOA 3H63A 4TUGA 2Q8UA 3E0JA 3RL5A 2BDXA 2A22A 4V0XA 1V73A 1OIDA 5JPEA 2BQ8X 5GTUA 4B2OA 4UT2A 4JA9A 1II7A 2NPPC 4OR9A 5C1VA 2R17A 3DW8C 5IOHA 2ZOAA 1S3MA 1HP1A 1JK7A 3RL4A 4KBPA 1HPUA 4H1SA 4IL1A 2YEQA 4YKEA 3E7AA 3N5UA 4H1YP 4O4KA 3V4YA 4F0ZA 2P6BA 1XZWA 3H67A 1HO5A 4Q7FA 2WDDA 3H66A 2AHDA 3H61A 4FBQA 4HD0A 5F3WA 2DFJA 4FBWA 4UWQA 2YVTA 2IE3C 3K7WC 4I5LC 1OI8A 3IVEA 5J28A 3H64A 5JPFA 3P71C 1NNWA 3C5WC 1T70A 2O8GA 5HPEA 2KKNA 2Z1AA 3AV0A 4XPNA 2IE4C 2NYLC 1SU1A 2GJUA 3HVQA 2BCDA 3H68A 3DSDA 4UT3B 2QFPA 3QFMA 2Z06A 2Z72A 3C9FA 4M0VA 1TCOA 2XMOA 3TGHA 3IB7A 1FJMA 4ZX2A 3LL8A 3E7BA 4NZVA 1S70A 5B8IA 2DXLA 4JA7A 4FCXA 3THNA 1QHWA 1MF8A 1XM7A 3D03A 2WDEA 3T1IA 1T71A 3AUZA 4ORAA 3JYFA 2DXNA 3KBPA 1S3NA 3PSNA 4H2IA 4UT3A 4TUIA 2QJCA 1S8EA 4O43A 3FGAC 4V0VA 2QFRA 3ZU0A 5EQVA 3H60A 4H2FA 4O5GA 1Z2XA 4J6OA 3IVDA 4WWLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3THO B;  5DNY A;  4MOY A;  3DSC A;  3RQZ A;  2JOG A;  4H2G A;  4FBK A;  3ZTV A;  4DSY A;  4IYP C;  4V0W A;  1KBP A;  4DT2 A;  1UTE A;  3H69 A;  1M63 A;  2CV9 A;  2O8A A;  4ORB A;  4ZVZ A;  4MOV A;  3EGG A;  5INB A;  1S3L A;  2NYM C;  1UF3 A;  2ZBM A;  3QFO A;  4ORC A;  3RL3 A;  3IB8 A;  2USH A;  4H2B A;  4O24 A;  1G5B A;  1S95 A;  3ICF A;  4LU9 A;  1USH A;  3QFK A;  3PSO A;  1QFC A;  1IT6 A;  5JJT A;  3H62 B;  3CK2 A;  4I5N C;  3QG5 C;  1AUI A;  4MP0 A;  1OIE A;  3GVE A;  3K7V C;  4LTY A;  4DHL A;  2IAE C;  1WAO 1;  1Z2W A;  2HYP A;  4KKZ A;  3EGH A;  2WDC A;  2HY1 A;  2NXF A;  4LAC C;  1U32 A;  2WDF A;  4G9J A;  1W24 A;  3QFN A;  1WAR A;  2HYO A;  3H63 A;  4TUG A;  2Q8U A;  3RL5 A;  2BDX A;  2A22 A;  4V0X A;  1V73 A;  1OID A;  5JPE A;  2BQ8 X;  5GTU A;  4B2O A;  4UT2 A;  4JA9 A;  1II7 A;  2NPP C;  4OR9 A;  5C1V A;  2R17 A;  3DW8 C;  5IOH A;  1S3M A;  1HP1 A;  1JK7 A;  3RL4 A;  4KBP A;  1HPU A;  4H1S A;  4IL1 A;  4YKE A;  3E7A A;  3N5U A;  4H1Y P;  4O4K A;  3V4Y A;  4F0Z A;  2P6B A;  1XZW A;  3H67 A;  1HO5 A;  4Q7F A;  2WDD A;  3H66 A;  2AHD A;  3H61 A;  4FBQ A;  4HD0 A;  5F3W A;  2DFJ A;  4FBW A;  4UWQ A;  2YVT A;  2IE3 C;  3K7W C;  4I5L C;  1OI8 A;  3IVE A;  5J28 A;  3H64 A;  5JPF A;  3P71 C;  1NNW A;  3C5W C;  1T70 A;  2O8G A;  5HPE A;  2KKN A;  2Z1A A;  3AV0 A;  4XPN A;  2IE4 C;  2NYL C;  1SU1 A;  2GJU A;  3HVQ A;  2BCD A;  3H68 A;  3DSD A;  4UT3 B;  2QFP A;  3QFM A;  2Z06 A;  2Z72 A;  3C9F A;  4M0V A;  1TCO A;  2XMO A;  3TGH A;  3IB7 A;  1FJM A;  4ZX2 A;  3LL8 A;  3E7B A;  4NZV A;  1S70 A;  5B8I A;  4JA7 A;  4FCX A;  3THN A;  1QHW A;  1MF8 A;  1XM7 A;  2WDE A;  3T1I A;  1T71 A;  3AUZ A;  4ORA A;  3JYF A;  3KBP A;  3PSN A;  1S3N A;  4H2I A;  4UT3 A;  4TUI A;  2QJC A;  1S8E A;  4O43 A;  3FGA C;  4V0V A;  2QFR A;  3ZU0 A;  5EQV A;  3H60 A;  4H2F A;  4O5G A;  1Z2X A;  4J6O A;  3IVD A;  4WWL A; 
#chains in the Genus database with same CATH topology
 3THO B;  5DNY A;  4MOY A;  3DSC A;  3RQZ A;  2JOG A;  4H2G A;  4FBK A;  3ZTV A;  4DSY A;  4IYP C;  3FLO A;  4V0W A;  1KBP A;  4DT2 A;  1UTE A;  3H69 A;  1M63 A;  2CV9 A;  2O8A A;  4ORB A;  4ZVZ A;  4MOV A;  3EGG A;  5INB A;  1S3L A;  2NYM C;  1UF3 A;  2ZBM A;  3QFO A;  4ORC A;  3RL3 A;  3IB8 A;  2USH A;  4H2B A;  4O24 A;  1G5B A;  1S95 A;  3ICF A;  4LU9 A;  1USH A;  3QFK A;  3PSO A;  1QFC A;  1IT6 A;  5JJT A;  3H62 B;  3CK2 A;  4I5N C;  3QG5 C;  1AUI A;  4MP0 A;  1OIE A;  3GVE A;  3K7V C;  4LTY A;  4DHL A;  2IAE C;  1WAO 1;  1Z2W A;  2HYP A;  4KKZ A;  3EGH A;  2WDC A;  2HY1 A;  2NXF A;  4LAC C;  1U32 A;  2WDF A;  2ZO9 B;  4G9J A;  1W24 A;  3QFN A;  1WAR A;  2HYO A;  3H63 A;  4TUG A;  2Q8U A;  3E0J A;  3RL5 A;  2BDX A;  2A22 A;  4V0X A;  1V73 A;  1OID A;  5JPE A;  2BQ8 X;  5GTU A;  4B2O A;  4UT2 A;  4JA9 A;  1II7 A;  2NPP C;  4OR9 A;  5C1V A;  2R17 A;  3DW8 C;  5IOH A;  2ZOA A;  1S3M A;  1HP1 A;  1JK7 A;  3RL4 A;  4KBP A;  1HPU A;  4H1S A;  4IL1 A;  2YEQ A;  4YKE A;  3E7A A;  3N5U A;  4H1Y P;  4O4K A;  3V4Y A;  4F0Z A;  2P6B A;  1XZW A;  3H67 A;  1HO5 A;  4Q7F A;  2WDD A;  3H66 A;  2AHD A;  3H61 A;  4FBQ A;  4HD0 A;  5F3W A;  2DFJ A;  4FBW A;  4UWQ A;  2YVT A;  2IE3 C;  3K7W C;  4I5L C;  1OI8 A;  3IVE A;  5J28 A;  3H64 A;  5JPF A;  3P71 C;  1NNW A;  3C5W C;  1T70 A;  2O8G A;  5HPE A;  2KKN A;  2Z1A A;  3AV0 A;  4XPN A;  2IE4 C;  2NYL C;  1SU1 A;  2GJU A;  3HVQ A;  2BCD A;  3H68 A;  3DSD A;  4UT3 B;  2QFP A;  3QFM A;  2Z06 A;  2Z72 A;  3C9F A;  4M0V A;  1TCO A;  2XMO A;  3TGH A;  3IB7 A;  1FJM A;  4ZX2 A;  3LL8 A;  3E7B A;  4NZV A;  1S70 A;  5B8I A;  2DXL A;  4JA7 A;  4FCX A;  3THN A;  1QHW A;  1MF8 A;  1XM7 A;  3D03 A;  2WDE A;  3T1I A;  1T71 A;  3AUZ A;  4ORA A;  3JYF A;  2DXN A;  3KBP A;  1S3N A;  3PSN A;  4H2I A;  4UT3 A;  4TUI A;  2QJC A;  1S8E A;  4O43 A;  3FGA C;  4V0V A;  2QFR A;  3ZU0 A;  5EQV A;  3H60 A;  4H2F A;  4O5G A;  1Z2X A;  4J6O A;  3IVD A;  4WWL A; 
#chains in the Genus database with same CATH homology
 3THO B;  5DNY A;  4MOY A;  3DSC A;  3RQZ A;  2JOG A;  4H2G A;  4FBK A;  3ZTV A;  4DSY A;  4IYP C;  3FLO A;  4V0W A;  1KBP A;  4DT2 A;  1UTE A;  3H69 A;  1M63 A;  2CV9 A;  2O8A A;  4ORB A;  4ZVZ A;  4MOV A;  3EGG A;  5INB A;  1S3L A;  2NYM C;  1UF3 A;  2ZBM A;  3QFO A;  4ORC A;  3RL3 A;  3IB8 A;  2USH A;  4H2B A;  4O24 A;  1G5B A;  1S95 A;  3ICF A;  4LU9 A;  1USH A;  3QFK A;  3PSO A;  1QFC A;  1IT6 A;  5JJT A;  3H62 B;  3CK2 A;  4I5N C;  3QG5 C;  1AUI A;  4MP0 A;  1OIE A;  3GVE A;  3K7V C;  4LTY A;  4DHL A;  2IAE C;  1WAO 1;  1Z2W A;  2HYP A;  4KKZ A;  3EGH A;  2WDC A;  2HY1 A;  2NXF A;  4LAC C;  1U32 A;  2WDF A;  2ZO9 B;  4G9J A;  1W24 A;  3QFN A;  1WAR A;  2HYO A;  3H63 A;  4TUG A;  2Q8U A;  3E0J A;  3RL5 A;  2BDX A;  2A22 A;  4V0X A;  1V73 A;  1OID A;  5JPE A;  2BQ8 X;  5GTU A;  4B2O A;  4UT2 A;  4JA9 A;  1II7 A;  2NPP C;  4OR9 A;  5C1V A;  2R17 A;  3DW8 C;  5IOH A;  2ZOA A;  1S3M A;  1HP1 A;  1JK7 A;  3RL4 A;  4KBP A;  1HPU A;  4H1S A;  4IL1 A;  2YEQ A;  4YKE A;  3E7A A;  3N5U A;  4H1Y P;  4O4K A;  3V4Y A;  4F0Z A;  2P6B A;  1XZW A;  3H67 A;  1HO5 A;  4Q7F A;  2WDD A;  3H66 A;  2AHD A;  3H61 A;  4FBQ A;  4HD0 A;  5F3W A;  2DFJ A;  4FBW A;  4UWQ A;  2YVT A;  2IE3 C;  3K7W C;  4I5L C;  1OI8 A;  3IVE A;  5J28 A;  3H64 A;  5JPF A;  3P71 C;  1NNW A;  3C5W C;  1T70 A;  2O8G A;  5HPE A;  2KKN A;  2Z1A A;  3AV0 A;  4XPN A;  2IE4 C;  2NYL C;  1SU1 A;  2GJU A;  3HVQ A;  2BCD A;  3H68 A;  3DSD A;  4UT3 B;  2QFP A;  3QFM A;  2Z06 A;  2Z72 A;  3C9F A;  4M0V A;  1TCO A;  2XMO A;  3TGH A;  3IB7 A;  1FJM A;  4ZX2 A;  3LL8 A;  3E7B A;  4NZV A;  1S70 A;  5B8I A;  2DXL A;  4JA7 A;  4FCX A;  3THN A;  1QHW A;  1MF8 A;  1XM7 A;  3D03 A;  2WDE A;  3T1I A;  1T71 A;  3AUZ A;  4ORA A;  3JYF A;  2DXN A;  3KBP A;  1S3N A;  3PSN A;  4H2I A;  4UT3 A;  4TUI A;  2QJC A;  1S8E A;  4O43 A;  3FGA C;  4V0V A;  2QFR A;  3ZU0 A;  5EQV A;  3H60 A;  4H2F A;  4O5G A;  1Z2X A;  4J6O A;  3IVD A;  4WWL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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