2IAEC

Crystal structure of a protein phosphatase 2a (pp2a) holoenzyme.
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
305
structure length
305
Chain Sequence
KVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVNRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Mus musculus
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 87
structure length 305
sequence length 305
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2iaeC00
2GJUA 4WWLA 4FCXA 2IAEC 1T70A 2XMOA 4F0ZA 3THNA 2HY1A 1WAO1 4J6OA 4XPNA 2NPPC 4IYPC 5J28A 2BQ8X 4ZX2A 3H67A 3IVEA 2R17A 3K7WC 4OR9A 1S3NA 3H60A 4ZVZA 1WARA 2WDDA 4IL1A 1S70A 1OIDA 4YKEA 1S3MA 2O8GA 2YVTA 4DT2A 1KBPA 3IVDA 4V0VA 3DSDA 3E7BA 3H66A 4B2OA 4LACC 1XZWA 2NYLC 2A22A 3ZTVA 4H2FA 4NZVA 3P71C 2KKNA 3QFNA 3AUZA 5JPEA 4MOYA 4H2GA 1SU1A 4MOVA 1QHWA 5EQVA 3CK2A 4H1SA 4I5LC 4O4KA 1T71A 1XM7A 3H63A 2AHDA 1V73A 1NNWA 1S8EA 1HO5A 3H68A 4UT2A 4UT3B 2HYOA 5HPEA 4M0VA 3H62B 3RL5A 3TGHA 3C5WC 4FBWA 2CV9A 2USHA 4KKZA 3H64A 4ORBA 5IOHA 3T1IA 3V4YA 1MF8A 1S3LA 2JOGA 1UTEA 3IB8A 2QFPA 1AUIA 3DW8C 4O5GA 1Z2WA 3EGGA 3ICFA 3PSOA 2QFRA 4MP0A 3QG5C 4H2BA 3RL3A 1UF3A 1II7A 4I5NC 4V0XA 5INBA 1FJMA 1JK7A 2HYPA 2WDEA 2P6BA 3QFKA 1U32A 4FBKA 3KBPA 4H1YP 4O43A 3JYFA 1S95A 3H61A 4V0WA 4FBQA 2Z72A 4LTYA 3THOB 1TCOA 4JA7A 4G9JA 1HP1A 3AV0A 2NXFA 4DSYA 4O24A 4UT3A 2WDFA 4HD0A 3IB7A 1QFCA 3LL8A 1IT6A 3FGAC 2BDXA 2NYMC 1M63A 1G5BA 2IE3C 2QJCA 2IE4C 4TUGA 3EGHA 3DSCA 5F3WA 2WDCA 4ORCA 3RQZA 3K7VC 1OI8A 4JA9A 1USHA 2ZBMA 5GTUA 5B8IA 3C9FA 2BCDA 4LU9A 3GVEA 4ORAA 3QFOA 5C1VA 3H69A 5JJTA 3QFMA 2Z06A 3HVQA 1Z2XA 1W24A 3RL4A 4TUIA 2O8AA 3N5UA 3E7AA 4Q7FA 2DFJA 5JPFA 1OIEA 5DNYA 4UWQA 1HPUA 3ZU0A 4KBPA 4DHLA 3PSNA 2Z1AA 2Q8UA 4H2IA
chains in the Genus database with same CATH superfamily
2GJUA 4WWLA 4FCXA 2IAEC 1T70A 2XMOA 4F0ZA 3THNA 2HY1A 1WAO1 3E0JA 3FLOA 4J6OA 4XPNA 2NPPC 4IYPC 5J28A 2BQ8X 4ZX2A 3H67A 3IVEA 2R17A 3K7WC 4OR9A 1S3NA 3H60A 4ZVZA 1WARA 2WDDA 4IL1A 1S70A 1OIDA 4YKEA 1S3MA 2O8GA 2YVTA 4DT2A 1KBPA 3IVDA 4V0VA 3DSDA 3E7BA 3H66A 4B2OA 4LACC 1XZWA 2NYLC 2A22A 3ZTVA 4H2FA 4NZVA 3P71C 2KKNA 3QFNA 3AUZA 5JPEA 4MOYA 4H2GA 1SU1A 4MOVA 1QHWA 5EQVA 3CK2A 4H1SA 4I5LC 4O4KA 1T71A 1XM7A 3H63A 2AHDA 1V73A 1NNWA 1S8EA 2ZOAA 1HO5A 3H68A 4UT2A 4UT3B 2DXLA 2HYOA 5HPEA 4M0VA 3H62B 3RL5A 3TGHA 3C5WC 4FBWA 2CV9A 2USHA 4KKZA 3H64A 4ORBA 5IOHA 3T1IA 3V4YA 1MF8A 1S3LA 2JOGA 1UTEA 3IB8A 2QFPA 1AUIA 3DW8C 4O5GA 1Z2WA 3EGGA 3ICFA 3PSOA 2QFRA 4MP0A 3QG5C 4H2BA 3RL3A 1UF3A 1II7A 4I5NC 2ZO9B 4V0XA 5INBA 1FJMA 1JK7A 2HYPA 2WDEA 2P6BA 3QFKA 1U32A 4FBKA 3KBPA 4H1YP 4O43A 3JYFA 1S95A 3H61A 4V0WA 4FBQA 2Z72A 4LTYA 3THOB 1TCOA 4JA7A 4G9JA 1HP1A 3AV0A 2NXFA 4DSYA 4O24A 4UT3A 2WDFA 4HD0A 3IB7A 1QFCA 3LL8A 1IT6A 3FGAC 3D03A 2BDXA 2NYMC 1M63A 1G5BA 2IE3C 2QJCA 2IE4C 4TUGA 3EGHA 3DSCA 5F3WA 2WDCA 4ORCA 3RQZA 3K7VC 1OI8A 4JA9A 1USHA 2ZBMA 5GTUA 5B8IA 3C9FA 2BCDA 4LU9A 3GVEA 4ORAA 3QFOA 5C1VA 3H69A 5JJTA 3QFMA 2Z06A 3HVQA 1Z2XA 1W24A 3RL4A 4TUIA 2O8AA 3N5UA 3E7AA 4Q7FA 2DFJA 5JPFA 1OIEA 5DNYA 4UWQA 1HPUA 3ZU0A 4KBPA 2DXNA 4DHLA 3PSNA 2Z1AA 2YEQA 2Q8UA 4H2IA
chains in the Genus database with same CATH topology
2GJUA 4WWLA 4FCXA 2IAEC 1T70A 2XMOA 4F0ZA 3THNA 2HY1A 1WAO1 3E0JA 3FLOA 4J6OA 4XPNA 2NPPC 4IYPC 5J28A 2BQ8X 4ZX2A 3H67A 3IVEA 2R17A 3K7WC 4OR9A 1S3NA 3H60A 4ZVZA 1WARA 2WDDA 4IL1A 1S70A 1OIDA 4YKEA 1S3MA 2O8GA 2YVTA 4DT2A 1KBPA 3IVDA 4V0VA 3DSDA 3E7BA 3H66A 4B2OA 4LACC 1XZWA 2NYLC 2A22A 3ZTVA 4H2FA 4NZVA 3P71C 2KKNA 3QFNA 3AUZA 5JPEA 4MOYA 4H2GA 1SU1A 4MOVA 1QHWA 5EQVA 3CK2A 4H1SA 4I5LC 4O4KA 1T71A 1XM7A 3H63A 2AHDA 1V73A 1NNWA 1S8EA 2ZOAA 1HO5A 3H68A 4UT2A 4UT3B 2DXLA 2HYOA 5HPEA 4M0VA 3H62B 3RL5A 3TGHA 3C5WC 4FBWA 2CV9A 2USHA 4KKZA 3H64A 4ORBA 5IOHA 3T1IA 3V4YA 1MF8A 1S3LA 2JOGA 1UTEA 3IB8A 2QFPA 1AUIA 3DW8C 4O5GA 1Z2WA 3EGGA 3ICFA 3PSOA 2QFRA 4MP0A 3QG5C 4H2BA 3RL3A 1UF3A 1II7A 4I5NC 2ZO9B 4V0XA 5INBA 1FJMA 1JK7A 2HYPA 2WDEA 2P6BA 3QFKA 1U32A 4FBKA 3KBPA 4H1YP 4O43A 3JYFA 1S95A 3H61A 4V0WA 4FBQA 2Z72A 4LTYA 3THOB 1TCOA 4JA7A 4G9JA 1HP1A 3AV0A 2NXFA 4DSYA 4O24A 4UT3A 2WDFA 4HD0A 3IB7A 1QFCA 3LL8A 1IT6A 3FGAC 3D03A 2BDXA 2NYMC 1M63A 1G5BA 2IE3C 2QJCA 2IE4C 4TUGA 3EGHA 3DSCA 5F3WA 2WDCA 4ORCA 3RQZA 3K7VC 1OI8A 4JA9A 1USHA 2ZBMA 5GTUA 5B8IA 3C9FA 2BCDA 4LU9A 3GVEA 4ORAA 3QFOA 5C1VA 3H69A 5JJTA 3QFMA 2Z06A 3HVQA 1Z2XA 1W24A 3RL4A 4TUIA 2O8AA 3N5UA 3E7AA 4Q7FA 2DFJA 5JPFA 1OIEA 5DNYA 4UWQA 1HPUA 3ZU0A 4KBPA 2DXNA 4DHLA 3PSNA 2Z1AA 2YEQA 2Q8UA 4H2IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GJU A;  4WWL A;  4FCX A;  2IAE C;  1T70 A;  2XMO A;  4F0Z A;  3THN A;  2HY1 A;  1WAO 1;  4J6O A;  4XPN A;  2NPP C;  4IYP C;  5J28 A;  2BQ8 X;  4ZX2 A;  3H67 A;  3IVE A;  2R17 A;  3K7W C;  4OR9 A;  1S3N A;  3H60 A;  4ZVZ A;  1WAR A;  2WDD A;  4IL1 A;  1S70 A;  1OID A;  4YKE A;  1S3M A;  2O8G A;  2YVT A;  4DT2 A;  1KBP A;  3IVD A;  4V0V A;  3DSD A;  3E7B A;  3H66 A;  4B2O A;  4LAC C;  1XZW A;  2NYL C;  2A22 A;  3ZTV A;  4H2F A;  4NZV A;  3P71 C;  2KKN A;  3QFN A;  3AUZ A;  5JPE A;  4MOY A;  4H2G A;  1SU1 A;  4MOV A;  1QHW A;  5EQV A;  3CK2 A;  4H1S A;  4I5L C;  4O4K A;  1T71 A;  1XM7 A;  3H63 A;  2AHD A;  1V73 A;  1NNW A;  1S8E A;  1HO5 A;  3H68 A;  4UT2 A;  4UT3 B;  2HYO A;  5HPE A;  4M0V A;  3H62 B;  3RL5 A;  3TGH A;  3C5W C;  4FBW A;  2CV9 A;  2USH A;  4KKZ A;  3H64 A;  4ORB A;  5IOH A;  3T1I A;  3V4Y A;  1MF8 A;  1S3L A;  2JOG A;  1UTE A;  3IB8 A;  2QFP A;  1AUI A;  3DW8 C;  4O5G A;  1Z2W A;  3EGG A;  3ICF A;  3PSO A;  2QFR A;  4MP0 A;  3QG5 C;  4H2B A;  3RL3 A;  1UF3 A;  1II7 A;  4I5N C;  4V0X A;  5INB A;  1FJM A;  1JK7 A;  2HYP A;  2WDE A;  2P6B A;  3QFK A;  1U32 A;  4FBK A;  3KBP A;  4H1Y P;  4O43 A;  3JYF A;  1S95 A;  3H61 A;  4V0W A;  4FBQ A;  2Z72 A;  4LTY A;  3THO B;  1TCO A;  4JA7 A;  4G9J A;  1HP1 A;  3AV0 A;  2NXF A;  4DSY A;  4O24 A;  4UT3 A;  2WDF A;  4HD0 A;  3IB7 A;  1QFC A;  3LL8 A;  1IT6 A;  3FGA C;  2BDX A;  2NYM C;  1M63 A;  1G5B A;  2IE3 C;  2QJC A;  2IE4 C;  4TUG A;  3EGH A;  3DSC A;  5F3W A;  2WDC A;  4ORC A;  3RQZ A;  3K7V C;  1OI8 A;  4JA9 A;  1USH A;  2ZBM A;  5GTU A;  5B8I A;  3C9F A;  2BCD A;  4LU9 A;  3GVE A;  4ORA A;  3QFO A;  5C1V A;  3H69 A;  5JJT A;  3QFM A;  2Z06 A;  3HVQ A;  1Z2X A;  1W24 A;  3RL4 A;  4TUI A;  2O8A A;  3N5U A;  3E7A A;  4Q7F A;  2DFJ A;  5JPF A;  1OIE A;  5DNY A;  4UWQ A;  1HPU A;  3ZU0 A;  4KBP A;  4DHL A;  3PSN A;  2Z1A A;  2Q8U A;  4H2I A; 
#chains in the Genus database with same CATH topology
 2GJU A;  4WWL A;  4FCX A;  2IAE C;  1T70 A;  2XMO A;  4F0Z A;  3THN A;  2HY1 A;  1WAO 1;  3E0J A;  3FLO A;  4J6O A;  4XPN A;  2NPP C;  4IYP C;  5J28 A;  2BQ8 X;  4ZX2 A;  3H67 A;  3IVE A;  2R17 A;  3K7W C;  4OR9 A;  1S3N A;  3H60 A;  4ZVZ A;  1WAR A;  2WDD A;  4IL1 A;  1S70 A;  1OID A;  4YKE A;  1S3M A;  2O8G A;  2YVT A;  4DT2 A;  1KBP A;  3IVD A;  4V0V A;  3DSD A;  3E7B A;  3H66 A;  4B2O A;  4LAC C;  1XZW A;  2NYL C;  2A22 A;  3ZTV A;  4H2F A;  4NZV A;  3P71 C;  2KKN A;  3QFN A;  3AUZ A;  5JPE A;  4MOY A;  4H2G A;  1SU1 A;  4MOV A;  1QHW A;  5EQV A;  3CK2 A;  4H1S A;  4I5L C;  4O4K A;  1T71 A;  1XM7 A;  3H63 A;  2AHD A;  1V73 A;  1NNW A;  1S8E A;  2ZOA A;  1HO5 A;  3H68 A;  4UT2 A;  4UT3 B;  2DXL A;  2HYO A;  5HPE A;  4M0V A;  3H62 B;  3RL5 A;  3TGH A;  3C5W C;  4FBW A;  2CV9 A;  2USH A;  4KKZ A;  3H64 A;  4ORB A;  5IOH A;  3T1I A;  3V4Y A;  1MF8 A;  1S3L A;  2JOG A;  1UTE A;  3IB8 A;  2QFP A;  1AUI A;  3DW8 C;  4O5G A;  1Z2W A;  3EGG A;  3ICF A;  3PSO A;  2QFR A;  4MP0 A;  3QG5 C;  4H2B A;  3RL3 A;  1UF3 A;  1II7 A;  4I5N C;  2ZO9 B;  4V0X A;  5INB A;  1FJM A;  1JK7 A;  2HYP A;  2WDE A;  2P6B A;  3QFK A;  1U32 A;  4FBK A;  3KBP A;  4H1Y P;  4O43 A;  3JYF A;  1S95 A;  3H61 A;  4V0W A;  4FBQ A;  2Z72 A;  4LTY A;  3THO B;  1TCO A;  4JA7 A;  4G9J A;  1HP1 A;  3AV0 A;  2NXF A;  4DSY A;  4O24 A;  4UT3 A;  2WDF A;  4HD0 A;  3IB7 A;  1QFC A;  3LL8 A;  1IT6 A;  3FGA C;  3D03 A;  2BDX A;  2NYM C;  1M63 A;  1G5B A;  2IE3 C;  2QJC A;  2IE4 C;  4TUG A;  3EGH A;  3DSC A;  5F3W A;  2WDC A;  4ORC A;  3RQZ A;  3K7V C;  1OI8 A;  4JA9 A;  1USH A;  2ZBM A;  5GTU A;  5B8I A;  3C9F A;  2BCD A;  4LU9 A;  3GVE A;  4ORA A;  3QFO A;  5C1V A;  3H69 A;  5JJT A;  3QFM A;  2Z06 A;  3HVQ A;  1Z2X A;  1W24 A;  3RL4 A;  4TUI A;  2O8A A;  3N5U A;  3E7A A;  4Q7F A;  2DFJ A;  5JPF A;  1OIE A;  5DNY A;  4UWQ A;  1HPU A;  3ZU0 A;  4KBP A;  2DXN A;  4DHL A;  3PSN A;  2Z1A A;  2YEQ A;  2Q8U A;  4H2I A; 
#chains in the Genus database with same CATH homology
 2GJU A;  4WWL A;  4FCX A;  2IAE C;  1T70 A;  2XMO A;  4F0Z A;  3THN A;  2HY1 A;  1WAO 1;  3E0J A;  3FLO A;  4J6O A;  4XPN A;  2NPP C;  4IYP C;  5J28 A;  2BQ8 X;  4ZX2 A;  3H67 A;  3IVE A;  2R17 A;  3K7W C;  4OR9 A;  1S3N A;  3H60 A;  4ZVZ A;  1WAR A;  2WDD A;  4IL1 A;  1S70 A;  1OID A;  4YKE A;  1S3M A;  2O8G A;  2YVT A;  4DT2 A;  1KBP A;  3IVD A;  4V0V A;  3DSD A;  3E7B A;  3H66 A;  4B2O A;  4LAC C;  1XZW A;  2NYL C;  2A22 A;  3ZTV A;  4H2F A;  4NZV A;  3P71 C;  2KKN A;  3QFN A;  3AUZ A;  5JPE A;  4MOY A;  4H2G A;  1SU1 A;  4MOV A;  1QHW A;  5EQV A;  3CK2 A;  4H1S A;  4I5L C;  4O4K A;  1T71 A;  1XM7 A;  3H63 A;  2AHD A;  1V73 A;  1NNW A;  1S8E A;  2ZOA A;  1HO5 A;  3H68 A;  4UT2 A;  4UT3 B;  2DXL A;  2HYO A;  5HPE A;  4M0V A;  3H62 B;  3RL5 A;  3TGH A;  3C5W C;  4FBW A;  2CV9 A;  2USH A;  4KKZ A;  3H64 A;  4ORB A;  5IOH A;  3T1I A;  3V4Y A;  1MF8 A;  1S3L A;  2JOG A;  1UTE A;  3IB8 A;  2QFP A;  1AUI A;  3DW8 C;  4O5G A;  1Z2W A;  3EGG A;  3ICF A;  3PSO A;  2QFR A;  4MP0 A;  3QG5 C;  4H2B A;  3RL3 A;  1UF3 A;  1II7 A;  4I5N C;  2ZO9 B;  4V0X A;  5INB A;  1FJM A;  1JK7 A;  2HYP A;  2WDE A;  2P6B A;  3QFK A;  1U32 A;  4FBK A;  3KBP A;  4H1Y P;  4O43 A;  3JYF A;  1S95 A;  3H61 A;  4V0W A;  4FBQ A;  2Z72 A;  4LTY A;  3THO B;  1TCO A;  4JA7 A;  4G9J A;  1HP1 A;  3AV0 A;  2NXF A;  4DSY A;  4O24 A;  4UT3 A;  2WDF A;  4HD0 A;  3IB7 A;  1QFC A;  3LL8 A;  1IT6 A;  3FGA C;  3D03 A;  2BDX A;  2NYM C;  1M63 A;  1G5B A;  2IE3 C;  2QJC A;  2IE4 C;  4TUG A;  3EGH A;  3DSC A;  5F3W A;  2WDC A;  4ORC A;  3RQZ A;  3K7V C;  1OI8 A;  4JA9 A;  1USH A;  2ZBM A;  5GTU A;  5B8I A;  3C9F A;  2BCD A;  4LU9 A;  3GVE A;  4ORA A;  3QFO A;  5C1V A;  3H69 A;  5JJT A;  3QFM A;  2Z06 A;  3HVQ A;  1Z2X A;  1W24 A;  3RL4 A;  4TUI A;  2O8A A;  3N5U A;  3E7A A;  4Q7F A;  2DFJ A;  5JPF A;  1OIE A;  5DNY A;  4UWQ A;  1HPU A;  3ZU0 A;  4KBP A;  2DXN A;  4DHL A;  3PSN A;  2Z1A A;  2YEQ A;  2Q8U A;  4H2I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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