2IE3C

Structure of the protein phosphatase 2a core enzyme bound to tumor-inducing toxins
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
pubmed doi rcsb
molecule tags Hydrolase/toxin
source organism Homo sapiens
molecule keywords Protein Phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 104
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-09-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2ie3C00
3JYFA 4MP0A 1HPUA 4JA9A 4I5NC 4M0VA 3FGAC 5C1VA 1WAO1 4UT3B 3P71C 1U32A 3IB7A 5DNYA 1AUIA 3IVEA 4LU9A 5J28A 1FJMA 2QFRA 1S8EA 2O8GA 4YKEA 4H2BA 2Z1AA 3AUZA 4ORCA 5B8IA 2BQ8X 4FCXA 1KBPA 3K7WC 2NYLC 4H2IA 1SU1A 2R17A 1OIDA 3H67A 2NYMC 2USHA 3H66A 5HPEA 4FBKA 1M63A 4H2FA 1MF8A 2WDDA 1QHWA 3ZU0A 1HP1A 5GTUA 3THOB 3PSOA 2WDEA 3N5UA 3QFOA 3HVQA 3C5WC 3QFKA 1HO5A 4NZVA 3DSDA 2NPPC 2KKNA 1V73A 3QG5C 4J6OA 4UT3A 4LTYA 1OI8A 3H61A 5EQVA 4V0WA 4V0VA 2WDCA 3H63A 1XZWA 2HY1A 4ZVZA 2AHDA 3DW8C 4ORBA 1G5BA 3TGHA 2A22A 2HYPA 4IYPC 3IB8A 4G9JA 4H2GA 4FBQA 3ICFA 1QFCA 4LACC 1W24A 3AV0A 4FBWA 3T1IA 4TUIA 3H60A 3RQZA 4DT2A 4I5LC 4TUGA 5INBA 2ZBMA 3H62B 1UF3A 4UT2A 1S3MA 3H69A 4DSYA 4JA7A 2Z72A 4V0XA 2GJUA 3THNA 1Z2WA 1NNWA 4O24A 3QFNA 1S3NA 3EGHA 1II7A 2WDFA 5JPEA 2P6BA 5JJTA 4MOVA 2IAEC 1T70A 3E7AA 2CV9A 3H64A 3CK2A 2Z06A 1T71A 3QFMA 4H1YP 4O43A 3ZTVA 2BDXA 4MOYA 4ORAA 4OR9A 1UTEA 5JPFA 4KKZA 1S3LA 1S95A 3E7BA 1OIEA 4IL1A 4XPNA 4DHLA 3DSCA 3EGGA 3IVDA 4F0ZA 4ZX2A 3K7VC 1IT6A 1Z2XA 5IOHA 4KBPA 4HD0A 4UWQA 3GVEA 2HYOA 2JOGA 1TCOA 4WWLA 4B2OA 3PSNA 2DFJA 2NXFA 3V4YA 3KBPA 1S70A 2BCDA 3H68A 2XMOA 4Q7FA 5F3WA 2QJCA 2Q8UA 4O5GA 2QFPA 1WARA 2YVTA 4H1SA 3RL3A 3RL4A 1JK7A 2IE3C 3C9FA 1USHA 3RL5A 2IE4C 4O4KA 1XM7A 3LL8A 2O8AA
chains in the Genus database with same CATH superfamily
3JYFA 4MP0A 1HPUA 4JA9A 4I5NC 4M0VA 3FGAC 5C1VA 1WAO1 4UT3B 3P71C 1U32A 3IB7A 5DNYA 1AUIA 3IVEA 4LU9A 3FLOA 5J28A 1FJMA 2QFRA 1S8EA 2O8GA 4YKEA 4H2BA 2Z1AA 2YEQA 3AUZA 4ORCA 5B8IA 2BQ8X 4FCXA 1KBPA 3K7WC 2NYLC 4H2IA 1SU1A 2R17A 1OIDA 3H67A 2NYMC 2USHA 3H66A 5HPEA 4FBKA 1M63A 4H2FA 1MF8A 2WDDA 1QHWA 3ZU0A 1HP1A 5GTUA 3THOB 3PSOA 2WDEA 3N5UA 3QFOA 3HVQA 3C5WC 3QFKA 1HO5A 4NZVA 3DSDA 2NPPC 2KKNA 1V73A 3QG5C 4J6OA 4UT3A 4LTYA 1OI8A 3D03A 3H61A 5EQVA 4V0WA 4V0VA 2WDCA 3H63A 1XZWA 2HY1A 4ZVZA 2AHDA 3DW8C 4ORBA 1G5BA 3TGHA 2A22A 2HYPA 4IYPC 3IB8A 4G9JA 4H2GA 4FBQA 3ICFA 1QFCA 4LACC 1W24A 3AV0A 4FBWA 3T1IA 4TUIA 2DXLA 2DXNA 3H60A 3RQZA 4DT2A 4I5LC 4TUGA 5INBA 2ZBMA 3H62B 1UF3A 4UT2A 1S3MA 3H69A 4DSYA 4JA7A 2Z72A 4V0XA 2GJUA 3THNA 1Z2WA 1NNWA 4O24A 3QFNA 1S3NA 3E0JA 1II7A 2WDFA 2ZOAA 3EGHA 5JPEA 2P6BA 5JJTA 2ZO9B 4MOVA 2IAEC 1T70A 3E7AA 2CV9A 3H64A 3CK2A 2Z06A 1T71A 3QFMA 4H1YP 4O43A 3ZTVA 2BDXA 4MOYA 4ORAA 4OR9A 1UTEA 5JPFA 4KKZA 1S3LA 1S95A 3E7BA 1OIEA 4IL1A 4XPNA 4DHLA 3DSCA 3EGGA 3IVDA 4F0ZA 4ZX2A 3K7VC 1IT6A 1Z2XA 5IOHA 4KBPA 4HD0A 4UWQA 3GVEA 2HYOA 2JOGA 1TCOA 4WWLA 4B2OA 3PSNA 2DFJA 2NXFA 3V4YA 3KBPA 1S70A 2BCDA 3H68A 2XMOA 4Q7FA 5F3WA 2QJCA 2Q8UA 4O5GA 2QFPA 1WARA 2YVTA 4H1SA 3RL3A 3RL4A 1JK7A 2IE3C 3C9FA 1USHA 3RL5A 2IE4C 4O4KA 1XM7A 3LL8A 2O8AA
chains in the Genus database with same CATH topology
3JYFA 4MP0A 1HPUA 4JA9A 4I5NC 4M0VA 3FGAC 5C1VA 1WAO1 4UT3B 3P71C 1U32A 3IB7A 5DNYA 1AUIA 3IVEA 4LU9A 3FLOA 5J28A 1FJMA 2QFRA 1S8EA 2O8GA 4YKEA 4H2BA 2Z1AA 2YEQA 3AUZA 4ORCA 5B8IA 2BQ8X 4FCXA 1KBPA 3K7WC 2NYLC 4H2IA 1SU1A 2R17A 1OIDA 3H67A 2NYMC 2USHA 3H66A 5HPEA 4FBKA 1M63A 4H2FA 1MF8A 2WDDA 1QHWA 3ZU0A 1HP1A 5GTUA 3THOB 3PSOA 2WDEA 3N5UA 3QFOA 3HVQA 3C5WC 3QFKA 1HO5A 4NZVA 3DSDA 2NPPC 2KKNA 1V73A 3QG5C 4J6OA 4UT3A 4LTYA 1OI8A 3D03A 3H61A 5EQVA 4V0WA 4V0VA 2WDCA 3H63A 1XZWA 2HY1A 4ZVZA 2AHDA 3DW8C 4ORBA 1G5BA 3TGHA 2A22A 2HYPA 4IYPC 3IB8A 4G9JA 4H2GA 4FBQA 3ICFA 1QFCA 4LACC 1W24A 3AV0A 4FBWA 3T1IA 4TUIA 2DXLA 2DXNA 3H60A 3RQZA 4DT2A 4I5LC 4TUGA 5INBA 2ZBMA 3H62B 1UF3A 4UT2A 1S3MA 3H69A 4DSYA 4JA7A 2Z72A 4V0XA 2GJUA 3THNA 1Z2WA 1NNWA 4O24A 3QFNA 1S3NA 3E0JA 1II7A 2WDFA 2ZOAA 3EGHA 5JPEA 2P6BA 5JJTA 2ZO9B 4MOVA 2IAEC 1T70A 3E7AA 2CV9A 3H64A 3CK2A 2Z06A 1T71A 3QFMA 4H1YP 4O43A 3ZTVA 2BDXA 4MOYA 4ORAA 4OR9A 1UTEA 5JPFA 4KKZA 1S3LA 1S95A 3E7BA 1OIEA 4IL1A 4XPNA 4DHLA 3DSCA 3EGGA 3IVDA 4F0ZA 4ZX2A 3K7VC 1IT6A 1Z2XA 5IOHA 4KBPA 4HD0A 4UWQA 3GVEA 2HYOA 2JOGA 1TCOA 4WWLA 4B2OA 3PSNA 2DFJA 2NXFA 3V4YA 3KBPA 1S70A 2BCDA 3H68A 2XMOA 4Q7FA 5F3WA 2QJCA 2Q8UA 4O5GA 2QFPA 1WARA 2YVTA 4H1SA 3RL3A 3RL4A 1JK7A 2IE3C 3C9FA 1USHA 3RL5A 2IE4C 4O4KA 1XM7A 3LL8A 2O8AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JYF A;  4MP0 A;  1HPU A;  4JA9 A;  4I5N C;  4M0V A;  3FGA C;  5C1V A;  1WAO 1;  4UT3 B;  3P71 C;  1U32 A;  3IB7 A;  5DNY A;  1AUI A;  3IVE A;  4LU9 A;  5J28 A;  1FJM A;  2QFR A;  1S8E A;  2O8G A;  4YKE A;  4H2B A;  2Z1A A;  3AUZ A;  4ORC A;  5B8I A;  2BQ8 X;  4FCX A;  1KBP A;  3K7W C;  2NYL C;  4H2I A;  1SU1 A;  2R17 A;  1OID A;  3H67 A;  2NYM C;  2USH A;  3H66 A;  5HPE A;  4FBK A;  1M63 A;  4H2F A;  1MF8 A;  2WDD A;  1QHW A;  3ZU0 A;  1HP1 A;  5GTU A;  3THO B;  3PSO A;  2WDE A;  3N5U A;  3QFO A;  3HVQ A;  3C5W C;  3QFK A;  1HO5 A;  4NZV A;  3DSD A;  2NPP C;  2KKN A;  1V73 A;  3QG5 C;  4J6O A;  4UT3 A;  4LTY A;  1OI8 A;  3H61 A;  5EQV A;  4V0W A;  4V0V A;  2WDC A;  3H63 A;  1XZW A;  2HY1 A;  4ZVZ A;  2AHD A;  3DW8 C;  4ORB A;  1G5B A;  3TGH A;  2A22 A;  2HYP A;  4IYP C;  3IB8 A;  4G9J A;  4H2G A;  4FBQ A;  3ICF A;  1QFC A;  4LAC C;  1W24 A;  3AV0 A;  4FBW A;  3T1I A;  4TUI A;  3H60 A;  3RQZ A;  4DT2 A;  4I5L C;  4TUG A;  5INB A;  2ZBM A;  3H62 B;  1UF3 A;  4UT2 A;  1S3M A;  3H69 A;  4DSY A;  4JA7 A;  2Z72 A;  4V0X A;  2GJU A;  3THN A;  1Z2W A;  1NNW A;  4O24 A;  3QFN A;  1S3N A;  3EGH A;  1II7 A;  2WDF A;  5JPE A;  2P6B A;  5JJT A;  4MOV A;  2IAE C;  1T70 A;  3E7A A;  2CV9 A;  3H64 A;  3CK2 A;  2Z06 A;  1T71 A;  3QFM A;  4H1Y P;  4O43 A;  3ZTV A;  2BDX A;  4MOY A;  4ORA A;  4OR9 A;  1UTE A;  5JPF A;  4KKZ A;  1S3L A;  1S95 A;  3E7B A;  1OIE A;  4IL1 A;  4XPN A;  4DHL A;  3DSC A;  3EGG A;  3IVD A;  4F0Z A;  4ZX2 A;  3K7V C;  1IT6 A;  1Z2X A;  5IOH A;  4KBP A;  4HD0 A;  4UWQ A;  3GVE A;  2HYO A;  2JOG A;  1TCO A;  4WWL A;  4B2O A;  3PSN A;  2DFJ A;  2NXF A;  3V4Y A;  3KBP A;  1S70 A;  2BCD A;  3H68 A;  2XMO A;  4Q7F A;  5F3W A;  2QJC A;  2Q8U A;  4O5G A;  2QFP A;  1WAR A;  2YVT A;  4H1S A;  3RL3 A;  3RL4 A;  1JK7 A;  2IE3 C;  3C9F A;  1USH A;  3RL5 A;  2IE4 C;  4O4K A;  1XM7 A;  3LL8 A;  2O8A A; 
#chains in the Genus database with same CATH topology
 3JYF A;  4MP0 A;  1HPU A;  4JA9 A;  4I5N C;  4M0V A;  3FGA C;  5C1V A;  1WAO 1;  4UT3 B;  3P71 C;  1U32 A;  3IB7 A;  5DNY A;  1AUI A;  3IVE A;  4LU9 A;  3FLO A;  5J28 A;  1FJM A;  2QFR A;  1S8E A;  2O8G A;  4YKE A;  4H2B A;  2Z1A A;  2YEQ A;  3AUZ A;  4ORC A;  5B8I A;  2BQ8 X;  4FCX A;  1KBP A;  3K7W C;  2NYL C;  4H2I A;  1SU1 A;  2R17 A;  1OID A;  3H67 A;  2NYM C;  2USH A;  3H66 A;  5HPE A;  4FBK A;  1M63 A;  4H2F A;  1MF8 A;  2WDD A;  1QHW A;  3ZU0 A;  1HP1 A;  5GTU A;  3THO B;  3PSO A;  2WDE A;  3N5U A;  3QFO A;  3HVQ A;  3C5W C;  3QFK A;  1HO5 A;  4NZV A;  3DSD A;  2NPP C;  2KKN A;  1V73 A;  3QG5 C;  4J6O A;  4UT3 A;  4LTY A;  1OI8 A;  3D03 A;  3H61 A;  5EQV A;  4V0W A;  4V0V A;  2WDC A;  3H63 A;  1XZW A;  2HY1 A;  4ZVZ A;  2AHD A;  3DW8 C;  4ORB A;  1G5B A;  3TGH A;  2A22 A;  2HYP A;  4IYP C;  3IB8 A;  4G9J A;  4H2G A;  4FBQ A;  3ICF A;  1QFC A;  4LAC C;  1W24 A;  3AV0 A;  4FBW A;  3T1I A;  4TUI A;  2DXL A;  2DXN A;  3H60 A;  3RQZ A;  4DT2 A;  4I5L C;  4TUG A;  5INB A;  2ZBM A;  3H62 B;  1UF3 A;  4UT2 A;  1S3M A;  3H69 A;  4DSY A;  4JA7 A;  2Z72 A;  4V0X A;  2GJU A;  3THN A;  1Z2W A;  1NNW A;  4O24 A;  3QFN A;  1S3N A;  3E0J A;  1II7 A;  2WDF A;  2ZOA A;  3EGH A;  5JPE A;  2P6B A;  5JJT A;  2ZO9 B;  4MOV A;  2IAE C;  1T70 A;  3E7A A;  2CV9 A;  3H64 A;  3CK2 A;  2Z06 A;  1T71 A;  3QFM A;  4H1Y P;  4O43 A;  3ZTV A;  2BDX A;  4MOY A;  4ORA A;  4OR9 A;  1UTE A;  5JPF A;  4KKZ A;  1S3L A;  1S95 A;  3E7B A;  1OIE A;  4IL1 A;  4XPN A;  4DHL A;  3DSC A;  3EGG A;  3IVD A;  4F0Z A;  4ZX2 A;  3K7V C;  1IT6 A;  1Z2X A;  5IOH A;  4KBP A;  4HD0 A;  4UWQ A;  3GVE A;  2HYO A;  2JOG A;  1TCO A;  4WWL A;  4B2O A;  3PSN A;  2DFJ A;  2NXF A;  3V4Y A;  3KBP A;  1S70 A;  2BCD A;  3H68 A;  2XMO A;  4Q7F A;  5F3W A;  2QJC A;  2Q8U A;  4O5G A;  2QFP A;  1WAR A;  2YVT A;  4H1S A;  3RL3 A;  3RL4 A;  1JK7 A;  2IE3 C;  3C9F A;  1USH A;  3RL5 A;  2IE4 C;  4O4K A;  1XM7 A;  3LL8 A;  2O8A A; 
#chains in the Genus database with same CATH homology
 3JYF A;  4MP0 A;  1HPU A;  4JA9 A;  4I5N C;  4M0V A;  3FGA C;  5C1V A;  1WAO 1;  4UT3 B;  3P71 C;  1U32 A;  3IB7 A;  5DNY A;  1AUI A;  3IVE A;  4LU9 A;  3FLO A;  5J28 A;  1FJM A;  2QFR A;  1S8E A;  2O8G A;  4YKE A;  4H2B A;  2Z1A A;  2YEQ A;  3AUZ A;  4ORC A;  5B8I A;  2BQ8 X;  4FCX A;  1KBP A;  3K7W C;  2NYL C;  4H2I A;  1SU1 A;  2R17 A;  1OID A;  3H67 A;  2NYM C;  2USH A;  3H66 A;  5HPE A;  4FBK A;  1M63 A;  4H2F A;  1MF8 A;  2WDD A;  1QHW A;  3ZU0 A;  1HP1 A;  5GTU A;  3THO B;  3PSO A;  2WDE A;  3N5U A;  3QFO A;  3HVQ A;  3C5W C;  3QFK A;  1HO5 A;  4NZV A;  3DSD A;  2NPP C;  2KKN A;  1V73 A;  3QG5 C;  4J6O A;  4UT3 A;  4LTY A;  1OI8 A;  3D03 A;  3H61 A;  5EQV A;  4V0W A;  4V0V A;  2WDC A;  3H63 A;  1XZW A;  2HY1 A;  4ZVZ A;  2AHD A;  3DW8 C;  4ORB A;  1G5B A;  3TGH A;  2A22 A;  2HYP A;  4IYP C;  3IB8 A;  4G9J A;  4H2G A;  4FBQ A;  3ICF A;  1QFC A;  4LAC C;  1W24 A;  3AV0 A;  4FBW A;  3T1I A;  4TUI A;  2DXL A;  2DXN A;  3H60 A;  3RQZ A;  4DT2 A;  4I5L C;  4TUG A;  5INB A;  2ZBM A;  3H62 B;  1UF3 A;  4UT2 A;  1S3M A;  3H69 A;  4DSY A;  4JA7 A;  2Z72 A;  4V0X A;  2GJU A;  3THN A;  1Z2W A;  1NNW A;  4O24 A;  3QFN A;  1S3N A;  3E0J A;  1II7 A;  2WDF A;  2ZOA A;  3EGH A;  5JPE A;  2P6B A;  5JJT A;  2ZO9 B;  4MOV A;  2IAE C;  1T70 A;  3E7A A;  2CV9 A;  3H64 A;  3CK2 A;  2Z06 A;  1T71 A;  3QFM A;  4H1Y P;  4O43 A;  3ZTV A;  2BDX A;  4MOY A;  4ORA A;  4OR9 A;  1UTE A;  5JPF A;  4KKZ A;  1S3L A;  1S95 A;  3E7B A;  1OIE A;  4IL1 A;  4XPN A;  4DHL A;  3DSC A;  3EGG A;  3IVD A;  4F0Z A;  4ZX2 A;  3K7V C;  1IT6 A;  1Z2X A;  5IOH A;  4KBP A;  4HD0 A;  4UWQ A;  3GVE A;  2HYO A;  2JOG A;  1TCO A;  4WWL A;  4B2O A;  3PSN A;  2DFJ A;  2NXF A;  3V4Y A;  3KBP A;  1S70 A;  2BCD A;  3H68 A;  2XMO A;  4Q7F A;  5F3W A;  2QJC A;  2Q8U A;  4O5G A;  2QFP A;  1WAR A;  2YVT A;  4H1S A;  3RL3 A;  3RL4 A;  1JK7 A;  2IE3 C;  3C9F A;  1USH A;  3RL5 A;  2IE4 C;  4O4K A;  1XM7 A;  3LL8 A;  2O8A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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