2IE4C

Structure of the protein phosphatase 2a core enzyme bound to okadaic acid
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
pubmed doi rcsb
molecule tags Signaling protein,hydrolase
source organism Homo sapiens
molecule keywords Protein Phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 101
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-09-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2ie4C00
4TUGA 1Z2XA 1M63A 1AUIA 2DFJA 1UF3A 1SU1A 4FBQA 4B2OA 4H2FA 4ORBA 4IYPC 2HY1A 3H68A 2BQ8X 2IAEC 3H62B 3QFNA 2USHA 3H61A 3V4YA 3IB8A 3DW8C 1S70A 3EGGA 4J6OA 1S95A 4H2IA 4HD0A 4YKEA 1JK7A 1Z2WA 2R17A 3C5WC 1OIEA 3QFKA 1W24A 4XPNA 1HO5A 1HP1A 1S8EA 4V0WA 5GTUA 1FJMA 3QFOA 1II7A 2BCDA 4OR9A 4WWLA 4O24A 3RL5A 3H66A 2CV9A 2YVTA 4ZX2A 3IVEA 4H2GA 4V0XA 4DHLA 5IOHA 3RQZA 2BDXA 1IT6A 3H69A 4FCXA 5JJTA 3HVQA 4KKZA 3RL4A 4F0ZA 1UTEA 1G5BA 2QFPA 3RL3A 4UT2A 1U32A 3EGHA 5JPEA 4DSYA 3H67A 2O8AA 1NNWA 2JOGA 3CK2A 2HYOA 1OIDA 2Q8UA 2ZBMA 3K7VC 5DNYA 3QFMA 1XZWA 4V0VA 4MP0A 3THOB 4O4KA 4MOYA 4NZVA 2WDDA 4ORCA 3ZU0A 3JYFA 3GVEA 3TGHA 1USHA 4LU9A 1KBPA 2GJUA 2Z72A 4Q7FA 4H1YP 4LTYA 1QFCA 2QFRA 2P6BA 3AUZA 2NYLC 1TCOA 3QG5C 1HPUA 1WARA 4I5NC 1S3LA 5J28A 4UT3A 1S3MA 5JPFA 2O8GA 4KBPA 4TUIA 3DSDA 4FBWA 3T1IA 4G9JA 4H2BA 4LACC 3ZTVA 4DT2A 3IVDA 4M0VA 3THNA 3LL8A 2NYMC 4O5GA 1T70A 4UWQA 2AHDA 3H60A 5B8IA 3KBPA 3PSNA 4UT3B 2HYPA 1MF8A 4IL1A 4MOVA 3N5UA 2NPPC 4JA9A 1WAO1 2Z1AA 2NXFA 3E7BA 2XMOA 3H64A 4I5LC 3C9FA 5HPEA 2Z06A 3ICFA 2IE3C 2WDFA 3AV0A 2IE4C 3IB7A 1OI8A 5F3WA 1XM7A 5INBA 4ORAA 2WDEA 1V73A 4FBKA 5C1VA 2A22A 1S3NA 1T71A 3FGAC 4JA7A 4ZVZA 3E7AA 3PSOA 4O43A 5EQVA 3P71C 2QJCA 3K7WC 4H1SA 3DSCA 1QHWA 2WDCA 3H63A 2KKNA
chains in the Genus database with same CATH superfamily
2YEQA 4TUGA 1Z2XA 1M63A 1AUIA 2DFJA 1UF3A 1SU1A 4FBQA 2DXNA 4B2OA 4H2FA 4ORBA 4IYPC 2HY1A 3FLOA 3H68A 2BQ8X 2IAEC 3H62B 3QFNA 2USHA 3H61A 3V4YA 3IB8A 3DW8C 1S70A 3EGGA 4J6OA 1S95A 4H2IA 4HD0A 4YKEA 1JK7A 1Z2WA 2R17A 3C5WC 1OIEA 3QFKA 1W24A 4XPNA 1HO5A 1HP1A 1S8EA 4V0WA 5GTUA 1FJMA 3QFOA 1II7A 2BCDA 4OR9A 4WWLA 4O24A 3RL5A 3H66A 2CV9A 2YVTA 4ZX2A 3IVEA 4H2GA 4V0XA 4DHLA 5IOHA 3RQZA 2BDXA 1IT6A 3H69A 4FCXA 5JJTA 3HVQA 4KKZA 3RL4A 4F0ZA 1UTEA 1G5BA 2QFPA 2ZOAA 4UT2A 3RL3A 1U32A 3EGHA 5JPEA 4DSYA 3H67A 2O8AA 1NNWA 2JOGA 3CK2A 2HYOA 1OIDA 2Q8UA 3D03A 2ZBMA 3K7VC 5DNYA 3QFMA 1XZWA 4V0VA 4MP0A 3THOB 4O4KA 4MOYA 2ZO9B 4NZVA 2WDDA 4ORCA 3ZU0A 3JYFA 3GVEA 3TGHA 1USHA 4LU9A 1KBPA 2GJUA 2Z72A 4Q7FA 4H1YP 4LTYA 1QFCA 2QFRA 2P6BA 3AUZA 2NYLC 1TCOA 3QG5C 1HPUA 1WARA 4I5NC 1S3LA 5J28A 4UT3A 1S3MA 5JPFA 2O8GA 4KBPA 4TUIA 3DSDA 4FBWA 3T1IA 4G9JA 4H2BA 4LACC 3ZTVA 4DT2A 3IVDA 4M0VA 3THNA 3LL8A 2NYMC 2DXLA 4O5GA 1T70A 4UWQA 2AHDA 3H60A 5B8IA 3KBPA 3PSNA 4UT3B 2HYPA 1MF8A 4IL1A 4MOVA 3E0JA 3N5UA 2NPPC 4JA9A 1WAO1 2Z1AA 2NXFA 3E7BA 2XMOA 3H64A 4I5LC 3C9FA 5HPEA 2Z06A 3ICFA 2IE3C 2WDFA 3AV0A 2IE4C 3IB7A 1OI8A 5F3WA 1XM7A 5INBA 4ORAA 2WDEA 1V73A 4FBKA 5C1VA 2A22A 1S3NA 1T71A 3FGAC 4JA7A 4ZVZA 3E7AA 3PSOA 4O43A 5EQVA 3P71C 2QJCA 3K7WC 4H1SA 3DSCA 1QHWA 2WDCA 3H63A 2KKNA
chains in the Genus database with same CATH topology
2YEQA 4TUGA 1Z2XA 1M63A 1AUIA 2DFJA 1UF3A 1SU1A 4FBQA 2DXNA 4B2OA 4H2FA 4ORBA 4IYPC 2HY1A 3FLOA 3H68A 2BQ8X 2IAEC 3H62B 3QFNA 2USHA 3H61A 3V4YA 3IB8A 3DW8C 1S70A 3EGGA 4J6OA 1S95A 4H2IA 4HD0A 4YKEA 1JK7A 1Z2WA 2R17A 3C5WC 1OIEA 3QFKA 1W24A 4XPNA 1HO5A 1HP1A 1S8EA 4V0WA 5GTUA 1FJMA 3QFOA 1II7A 2BCDA 4OR9A 4WWLA 4O24A 3RL5A 3H66A 2CV9A 2YVTA 4ZX2A 3IVEA 4H2GA 4V0XA 4DHLA 5IOHA 3RQZA 2BDXA 1IT6A 3H69A 4FCXA 5JJTA 3HVQA 4KKZA 3RL4A 4F0ZA 1UTEA 1G5BA 2QFPA 2ZOAA 4UT2A 3RL3A 1U32A 3EGHA 5JPEA 4DSYA 3H67A 2O8AA 1NNWA 2JOGA 3CK2A 2HYOA 1OIDA 2Q8UA 3D03A 2ZBMA 3K7VC 5DNYA 3QFMA 1XZWA 4V0VA 4MP0A 3THOB 4O4KA 4MOYA 2ZO9B 4NZVA 2WDDA 4ORCA 3ZU0A 3JYFA 3GVEA 3TGHA 1USHA 4LU9A 1KBPA 2GJUA 2Z72A 4Q7FA 4H1YP 4LTYA 1QFCA 2QFRA 2P6BA 3AUZA 2NYLC 1TCOA 3QG5C 1HPUA 1WARA 4I5NC 1S3LA 5J28A 4UT3A 1S3MA 5JPFA 2O8GA 4KBPA 4TUIA 3DSDA 4FBWA 3T1IA 4G9JA 4H2BA 4LACC 3ZTVA 4DT2A 3IVDA 4M0VA 3THNA 3LL8A 2NYMC 2DXLA 4O5GA 1T70A 4UWQA 2AHDA 3H60A 5B8IA 3KBPA 3PSNA 4UT3B 2HYPA 1MF8A 4IL1A 4MOVA 3E0JA 3N5UA 2NPPC 4JA9A 1WAO1 2Z1AA 2NXFA 3E7BA 2XMOA 3H64A 4I5LC 3C9FA 5HPEA 2Z06A 3ICFA 2IE3C 2WDFA 3AV0A 2IE4C 3IB7A 1OI8A 5F3WA 1XM7A 5INBA 4ORAA 2WDEA 1V73A 4FBKA 5C1VA 2A22A 1S3NA 1T71A 3FGAC 4JA7A 4ZVZA 3E7AA 3PSOA 4O43A 5EQVA 3P71C 2QJCA 3K7WC 4H1SA 3DSCA 1QHWA 2WDCA 3H63A 2KKNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TUG A;  1Z2X A;  1M63 A;  1AUI A;  2DFJ A;  1UF3 A;  1SU1 A;  4FBQ A;  4B2O A;  4H2F A;  4ORB A;  4IYP C;  2HY1 A;  3H68 A;  2BQ8 X;  2IAE C;  3H62 B;  3QFN A;  2USH A;  3H61 A;  3V4Y A;  3IB8 A;  3DW8 C;  1S70 A;  3EGG A;  4J6O A;  1S95 A;  4H2I A;  4HD0 A;  4YKE A;  1JK7 A;  1Z2W A;  2R17 A;  3C5W C;  1OIE A;  3QFK A;  1W24 A;  4XPN A;  1HO5 A;  1HP1 A;  1S8E A;  4V0W A;  5GTU A;  1FJM A;  3QFO A;  1II7 A;  2BCD A;  4OR9 A;  4WWL A;  4O24 A;  3RL5 A;  3H66 A;  2CV9 A;  2YVT A;  4ZX2 A;  3IVE A;  4H2G A;  4V0X A;  4DHL A;  5IOH A;  3RQZ A;  2BDX A;  1IT6 A;  3H69 A;  4FCX A;  5JJT A;  3HVQ A;  4KKZ A;  3RL4 A;  4F0Z A;  1UTE A;  1G5B A;  2QFP A;  3RL3 A;  4UT2 A;  1U32 A;  3EGH A;  5JPE A;  4DSY A;  3H67 A;  2O8A A;  1NNW A;  2JOG A;  3CK2 A;  2HYO A;  1OID A;  2Q8U A;  2ZBM A;  3K7V C;  5DNY A;  3QFM A;  1XZW A;  4V0V A;  4MP0 A;  3THO B;  4O4K A;  4MOY A;  4NZV A;  2WDD A;  4ORC A;  3ZU0 A;  3JYF A;  3GVE A;  3TGH A;  1USH A;  4LU9 A;  1KBP A;  2GJU A;  2Z72 A;  4Q7F A;  4H1Y P;  4LTY A;  1QFC A;  2QFR A;  2P6B A;  3AUZ A;  2NYL C;  1TCO A;  3QG5 C;  1HPU A;  1WAR A;  4I5N C;  1S3L A;  5J28 A;  4UT3 A;  1S3M A;  5JPF A;  2O8G A;  4KBP A;  4TUI A;  3DSD A;  4FBW A;  3T1I A;  4G9J A;  4H2B A;  4LAC C;  3ZTV A;  4DT2 A;  3IVD A;  4M0V A;  3THN A;  3LL8 A;  2NYM C;  4O5G A;  1T70 A;  4UWQ A;  2AHD A;  3H60 A;  5B8I A;  3KBP A;  3PSN A;  4UT3 B;  2HYP A;  1MF8 A;  4IL1 A;  4MOV A;  3N5U A;  2NPP C;  4JA9 A;  1WAO 1;  2Z1A A;  2NXF A;  3E7B A;  2XMO A;  3H64 A;  4I5L C;  3C9F A;  5HPE A;  2Z06 A;  3ICF A;  2IE3 C;  2WDF A;  3AV0 A;  2IE4 C;  3IB7 A;  1OI8 A;  5F3W A;  1XM7 A;  5INB A;  4ORA A;  2WDE A;  1V73 A;  4FBK A;  5C1V A;  2A22 A;  1S3N A;  1T71 A;  3FGA C;  4JA7 A;  4ZVZ A;  3E7A A;  3PSO A;  4O43 A;  5EQV A;  3P71 C;  2QJC A;  3K7W C;  4H1S A;  3DSC A;  1QHW A;  2WDC A;  3H63 A;  2KKN A; 
#chains in the Genus database with same CATH topology
 2YEQ A;  4TUG A;  1Z2X A;  1M63 A;  1AUI A;  2DFJ A;  1UF3 A;  1SU1 A;  4FBQ A;  2DXN A;  4B2O A;  4H2F A;  4ORB A;  4IYP C;  2HY1 A;  3FLO A;  3H68 A;  2BQ8 X;  2IAE C;  3H62 B;  3QFN A;  2USH A;  3H61 A;  3V4Y A;  3IB8 A;  3DW8 C;  1S70 A;  3EGG A;  4J6O A;  1S95 A;  4H2I A;  4HD0 A;  4YKE A;  1JK7 A;  1Z2W A;  2R17 A;  3C5W C;  1OIE A;  3QFK A;  1W24 A;  4XPN A;  1HO5 A;  1HP1 A;  1S8E A;  4V0W A;  5GTU A;  1FJM A;  3QFO A;  1II7 A;  2BCD A;  4OR9 A;  4WWL A;  4O24 A;  3RL5 A;  3H66 A;  2CV9 A;  2YVT A;  4ZX2 A;  3IVE A;  4H2G A;  4V0X A;  4DHL A;  5IOH A;  3RQZ A;  2BDX A;  1IT6 A;  3H69 A;  4FCX A;  5JJT A;  3HVQ A;  4KKZ A;  3RL4 A;  4F0Z A;  1UTE A;  1G5B A;  2QFP A;  2ZOA A;  4UT2 A;  3RL3 A;  1U32 A;  3EGH A;  5JPE A;  4DSY A;  3H67 A;  2O8A A;  1NNW A;  2JOG A;  3CK2 A;  2HYO A;  1OID A;  2Q8U A;  3D03 A;  2ZBM A;  3K7V C;  5DNY A;  3QFM A;  1XZW A;  4V0V A;  4MP0 A;  3THO B;  4O4K A;  4MOY A;  2ZO9 B;  4NZV A;  2WDD A;  4ORC A;  3ZU0 A;  3JYF A;  3GVE A;  3TGH A;  1USH A;  4LU9 A;  1KBP A;  2GJU A;  2Z72 A;  4Q7F A;  4H1Y P;  4LTY A;  1QFC A;  2QFR A;  2P6B A;  3AUZ A;  2NYL C;  1TCO A;  3QG5 C;  1HPU A;  1WAR A;  4I5N C;  1S3L A;  5J28 A;  4UT3 A;  1S3M A;  5JPF A;  2O8G A;  4KBP A;  4TUI A;  3DSD A;  4FBW A;  3T1I A;  4G9J A;  4H2B A;  4LAC C;  3ZTV A;  4DT2 A;  3IVD A;  4M0V A;  3THN A;  3LL8 A;  2NYM C;  2DXL A;  4O5G A;  1T70 A;  4UWQ A;  2AHD A;  3H60 A;  5B8I A;  3KBP A;  3PSN A;  4UT3 B;  2HYP A;  1MF8 A;  4IL1 A;  4MOV A;  3E0J A;  3N5U A;  2NPP C;  4JA9 A;  1WAO 1;  2Z1A A;  2NXF A;  3E7B A;  2XMO A;  3H64 A;  4I5L C;  3C9F A;  5HPE A;  2Z06 A;  3ICF A;  2IE3 C;  2WDF A;  3AV0 A;  2IE4 C;  3IB7 A;  1OI8 A;  5F3W A;  1XM7 A;  5INB A;  4ORA A;  2WDE A;  1V73 A;  4FBK A;  5C1V A;  2A22 A;  1S3N A;  1T71 A;  3FGA C;  4JA7 A;  4ZVZ A;  3E7A A;  3PSO A;  4O43 A;  5EQV A;  3P71 C;  2QJC A;  3K7W C;  4H1S A;  3DSC A;  1QHW A;  2WDC A;  3H63 A;  2KKN A; 
#chains in the Genus database with same CATH homology
 2YEQ A;  4TUG A;  1Z2X A;  1M63 A;  1AUI A;  2DFJ A;  1UF3 A;  1SU1 A;  4FBQ A;  2DXN A;  4B2O A;  4H2F A;  4ORB A;  4IYP C;  2HY1 A;  3FLO A;  3H68 A;  2BQ8 X;  2IAE C;  3H62 B;  3QFN A;  2USH A;  3H61 A;  3V4Y A;  3IB8 A;  3DW8 C;  1S70 A;  3EGG A;  4J6O A;  1S95 A;  4H2I A;  4HD0 A;  4YKE A;  1JK7 A;  1Z2W A;  2R17 A;  3C5W C;  1OIE A;  3QFK A;  1W24 A;  4XPN A;  1HO5 A;  1HP1 A;  1S8E A;  4V0W A;  5GTU A;  1FJM A;  3QFO A;  1II7 A;  2BCD A;  4OR9 A;  4WWL A;  4O24 A;  3RL5 A;  3H66 A;  2CV9 A;  2YVT A;  4ZX2 A;  3IVE A;  4H2G A;  4V0X A;  4DHL A;  5IOH A;  3RQZ A;  2BDX A;  1IT6 A;  3H69 A;  4FCX A;  5JJT A;  3HVQ A;  4KKZ A;  3RL4 A;  4F0Z A;  1UTE A;  1G5B A;  2QFP A;  2ZOA A;  4UT2 A;  3RL3 A;  1U32 A;  3EGH A;  5JPE A;  4DSY A;  3H67 A;  2O8A A;  1NNW A;  2JOG A;  3CK2 A;  2HYO A;  1OID A;  2Q8U A;  3D03 A;  2ZBM A;  3K7V C;  5DNY A;  3QFM A;  1XZW A;  4V0V A;  4MP0 A;  3THO B;  4O4K A;  4MOY A;  2ZO9 B;  4NZV A;  2WDD A;  4ORC A;  3ZU0 A;  3JYF A;  3GVE A;  3TGH A;  1USH A;  4LU9 A;  1KBP A;  2GJU A;  2Z72 A;  4Q7F A;  4H1Y P;  4LTY A;  1QFC A;  2QFR A;  2P6B A;  3AUZ A;  2NYL C;  1TCO A;  3QG5 C;  1HPU A;  1WAR A;  4I5N C;  1S3L A;  5J28 A;  4UT3 A;  1S3M A;  5JPF A;  2O8G A;  4KBP A;  4TUI A;  3DSD A;  4FBW A;  3T1I A;  4G9J A;  4H2B A;  4LAC C;  3ZTV A;  4DT2 A;  3IVD A;  4M0V A;  3THN A;  3LL8 A;  2NYM C;  2DXL A;  4O5G A;  1T70 A;  4UWQ A;  2AHD A;  3H60 A;  5B8I A;  3KBP A;  3PSN A;  4UT3 B;  2HYP A;  1MF8 A;  4IL1 A;  4MOV A;  3E0J A;  3N5U A;  2NPP C;  4JA9 A;  1WAO 1;  2Z1A A;  2NXF A;  3E7B A;  2XMO A;  3H64 A;  4I5L C;  3C9F A;  5HPE A;  2Z06 A;  3ICF A;  2IE3 C;  2WDF A;  3AV0 A;  2IE4 C;  3IB7 A;  1OI8 A;  5F3W A;  1XM7 A;  5INB A;  4ORA A;  2WDE A;  1V73 A;  4FBK A;  5C1V A;  2A22 A;  1S3N A;  1T71 A;  3FGA C;  4JA7 A;  4ZVZ A;  3E7A A;  3PSO A;  4O43 A;  5EQV A;  3P71 C;  2QJC A;  3K7W C;  4H1S A;  3DSC A;  1QHW A;  2WDC A;  3H63 A;  2KKN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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