2NYLC

Crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 91
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nylC00
3T1IA 4MP0A 2AHDA 1JK7A 2WDEA 4ZX2A 1TCOA 2WDFA 2BDXA 2QJCA 2YVTA 4DSYA 3H62B 4H1YP 3CK2A 4UT2A 2O8GA 1XZWA 3EGHA 3DSCA 4TUGA 1SU1A 1S70A 2DFJA 2WDDA 3P71C 1W24A 3IB8A 2NYMC 1S3LA 2ZBMA 2A22A 3H66A 4IYPC 2XMOA 1M63A 4H2IA 5HPEA 2O8AA 4O5GA 5EQVA 4J6OA 4LACC 2GJUA 3IVEA 3E7BA 2IE4C 2QFPA 4JA9A 3JYFA 5C1VA 4H2GA 5JPFA 1MF8A 3THOB 4ORBA 1FJMA 3HVQA 3H61A 3DSDA 5B8IA 2Z72A 2HY1A 2Z06A 4H2FA 1OIDA 1QHWA 2IAEC 4V0WA 4ORAA 2BCDA 2NYLC 1UTEA 3AV0A 4HD0A 1IT6A 3ICFA 3GVEA 2Z1AA 4V0VA 1QFCA 3V4YA 3ZU0A 3RL4A 1S3NA 1S8EA 4H1SA 4XPNA 4UT3A 4FBKA 5INBA 2NXFA 1HP1A 3PSNA 1XM7A 4TUIA 4KBPA 3QFKA 3LL8A 4M0VA 1HO5A 3RL3A 5IOHA 4MOYA 4Q7FA 4ORCA 3KBPA 4O24A 3PSOA 5J28A 3EGGA 1S95A 4B2OA 3IB7A 4F0ZA 1OI8A 2HYOA 5JJTA 4ZVZA 1OIEA 3H63A 4KKZA 3H60A 2USHA 4UT3B 3H67A 4OR9A 3RL5A 4O4KA 1WAO1 3K7VC 2CV9A 3H69A 4YKEA 3N5UA 1USHA 3C9FA 3QG5C 3H68A 4DT2A 3TGHA 1UF3A 3IVDA 1S3MA 3H64A 4G9JA 3AUZA 4JA7A 4MOVA 4LTYA 1AUIA 1T71A 1U32A 3DW8C 4FCXA 4FBQA 4UWQA 2BQ8X 3ZTVA 2P6BA 1T70A 4V0XA 4DHLA 3QFOA 5F3WA 4IL1A 3QFNA 1Z2XA 3E7AA 4I5LC 5DNYA 2JOGA 2IE3C 4WWLA 2HYPA 4FBWA 3THNA 3K7WC 2QFRA 1KBPA 3QFMA 4I5NC 3RQZA 1Z2WA 2R17A 2WDCA 1II7A 2Q8UA 4O43A 2KKNA 1HPUA 4LU9A 1NNWA 1V73A 1WARA 5GTUA 2NPPC 4NZVA 5JPEA 4H2BA 1G5BA 3FGAC 3C5WC
chains in the Genus database with same CATH superfamily
3T1IA 4MP0A 2AHDA 1JK7A 2WDEA 3D03A 4ZX2A 1TCOA 2WDFA 2BDXA 2QJCA 2YVTA 4DSYA 3H62B 4H1YP 3CK2A 4UT2A 2O8GA 1XZWA 3EGHA 3DSCA 4TUGA 1SU1A 1S70A 2DFJA 2WDDA 3P71C 1W24A 3IB8A 2NYMC 1S3LA 3E0JA 2ZBMA 2A22A 3H66A 4IYPC 2XMOA 1M63A 4H2IA 5HPEA 2O8AA 4O5GA 5EQVA 4J6OA 4LACC 2GJUA 3IVEA 3E7BA 2IE4C 2QFPA 4JA9A 3JYFA 5C1VA 4H2GA 5JPFA 1MF8A 3THOB 4ORBA 1FJMA 3HVQA 3H61A 3DSDA 5B8IA 2Z72A 2HY1A 2Z06A 4H2FA 1OIDA 1QHWA 2IAEC 4V0WA 4ORAA 2BCDA 2NYLC 1UTEA 3AV0A 4HD0A 1IT6A 3ICFA 3GVEA 2Z1AA 4V0VA 1QFCA 3V4YA 2DXNA 3ZU0A 3RL4A 1S3NA 1S8EA 4H1SA 4XPNA 4UT3A 4FBKA 5INBA 2NXFA 1HP1A 3PSNA 1XM7A 4TUIA 4KBPA 3QFKA 3LL8A 4M0VA 1HO5A 3RL3A 5IOHA 4MOYA 4Q7FA 4ORCA 3KBPA 4O24A 3PSOA 5J28A 3EGGA 1S95A 4B2OA 3IB7A 4F0ZA 1OI8A 2HYOA 5JJTA 4ZVZA 1OIEA 3H63A 4KKZA 3H60A 2USHA 4UT3B 3H67A 4OR9A 3RL5A 4O4KA 1WAO1 3K7VC 2CV9A 3H69A 4YKEA 2DXLA 3N5UA 1USHA 3C9FA 3QG5C 3H68A 4DT2A 3TGHA 1UF3A 3IVDA 1S3MA 3H64A 4G9JA 3AUZA 4JA7A 4MOVA 4LTYA 1AUIA 1T71A 1U32A 3DW8C 4FCXA 4FBQA 4UWQA 2BQ8X 3ZTVA 2P6BA 1T70A 4V0XA 4DHLA 3QFOA 5F3WA 4IL1A 3QFNA 1Z2XA 3E7AA 4I5LC 3FLOA 5DNYA 2ZO9B 2JOGA 2IE3C 4WWLA 2HYPA 4FBWA 2YEQA 3THNA 3K7WC 2QFRA 2ZOAA 1KBPA 3QFMA 4I5NC 3RQZA 1Z2WA 2R17A 2WDCA 1II7A 2Q8UA 4O43A 2KKNA 1HPUA 4LU9A 1NNWA 1V73A 1WARA 5GTUA 2NPPC 4NZVA 5JPEA 4H2BA 1G5BA 3FGAC 3C5WC
chains in the Genus database with same CATH topology
3T1IA 4MP0A 2AHDA 1JK7A 2WDEA 3D03A 4ZX2A 1TCOA 2WDFA 2BDXA 2QJCA 2YVTA 4DSYA 3H62B 4H1YP 3CK2A 4UT2A 2O8GA 1XZWA 3EGHA 3DSCA 4TUGA 1SU1A 1S70A 2DFJA 2WDDA 3P71C 1W24A 3IB8A 2NYMC 1S3LA 3E0JA 2ZBMA 2A22A 3H66A 4IYPC 2XMOA 1M63A 4H2IA 5HPEA 2O8AA 4O5GA 5EQVA 4J6OA 4LACC 2GJUA 3IVEA 3E7BA 2IE4C 2QFPA 4JA9A 3JYFA 5C1VA 4H2GA 5JPFA 1MF8A 3THOB 4ORBA 1FJMA 3HVQA 3H61A 3DSDA 5B8IA 2Z72A 2HY1A 2Z06A 4H2FA 1OIDA 1QHWA 2IAEC 4V0WA 4ORAA 2BCDA 2NYLC 1UTEA 3AV0A 4HD0A 1IT6A 3ICFA 3GVEA 2Z1AA 4V0VA 1QFCA 3V4YA 2DXNA 3ZU0A 3RL4A 1S3NA 1S8EA 4H1SA 4XPNA 4UT3A 4FBKA 5INBA 2NXFA 1HP1A 3PSNA 1XM7A 4TUIA 4KBPA 3QFKA 3LL8A 4M0VA 1HO5A 3RL3A 5IOHA 4MOYA 4Q7FA 4ORCA 3KBPA 4O24A 3PSOA 5J28A 3EGGA 1S95A 4B2OA 3IB7A 4F0ZA 1OI8A 2HYOA 5JJTA 4ZVZA 1OIEA 3H63A 4KKZA 3H60A 2USHA 4UT3B 3H67A 4OR9A 3RL5A 4O4KA 1WAO1 3K7VC 2CV9A 3H69A 4YKEA 2DXLA 3N5UA 1USHA 3C9FA 3QG5C 3H68A 4DT2A 3TGHA 1UF3A 3IVDA 1S3MA 3H64A 4G9JA 3AUZA 4JA7A 4MOVA 4LTYA 1AUIA 1T71A 1U32A 3DW8C 4FCXA 4FBQA 4UWQA 2BQ8X 3ZTVA 2P6BA 1T70A 4V0XA 4DHLA 3QFOA 5F3WA 4IL1A 3QFNA 1Z2XA 3E7AA 4I5LC 3FLOA 5DNYA 2ZO9B 2JOGA 2IE3C 4WWLA 2HYPA 4FBWA 2YEQA 3THNA 3K7WC 2QFRA 2ZOAA 1KBPA 3QFMA 4I5NC 3RQZA 1Z2WA 2R17A 2WDCA 1II7A 2Q8UA 4O43A 2KKNA 1HPUA 4LU9A 1NNWA 1V73A 1WARA 5GTUA 2NPPC 4NZVA 5JPEA 4H2BA 1G5BA 3FGAC 3C5WC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T1I A;  4MP0 A;  2AHD A;  1JK7 A;  2WDE A;  4ZX2 A;  1TCO A;  2WDF A;  2BDX A;  2QJC A;  2YVT A;  4DSY A;  3H62 B;  4H1Y P;  3CK2 A;  4UT2 A;  2O8G A;  1XZW A;  3EGH A;  3DSC A;  4TUG A;  1SU1 A;  1S70 A;  2DFJ A;  2WDD A;  3P71 C;  1W24 A;  3IB8 A;  2NYM C;  1S3L A;  2ZBM A;  2A22 A;  3H66 A;  4IYP C;  2XMO A;  1M63 A;  4H2I A;  5HPE A;  2O8A A;  4O5G A;  5EQV A;  4J6O A;  4LAC C;  2GJU A;  3IVE A;  3E7B A;  2IE4 C;  2QFP A;  4JA9 A;  3JYF A;  5C1V A;  4H2G A;  5JPF A;  1MF8 A;  3THO B;  4ORB A;  1FJM A;  3HVQ A;  3H61 A;  3DSD A;  5B8I A;  2Z72 A;  2HY1 A;  2Z06 A;  4H2F A;  1OID A;  1QHW A;  2IAE C;  4V0W A;  4ORA A;  2BCD A;  2NYL C;  1UTE A;  3AV0 A;  4HD0 A;  1IT6 A;  3ICF A;  3GVE A;  2Z1A A;  4V0V A;  1QFC A;  3V4Y A;  3ZU0 A;  3RL4 A;  1S3N A;  1S8E A;  4H1S A;  4XPN A;  4UT3 A;  4FBK A;  5INB A;  2NXF A;  1HP1 A;  3PSN A;  1XM7 A;  4TUI A;  4KBP A;  3QFK A;  3LL8 A;  4M0V A;  1HO5 A;  3RL3 A;  5IOH A;  4MOY A;  4Q7F A;  4ORC A;  3KBP A;  4O24 A;  3PSO A;  5J28 A;  3EGG A;  1S95 A;  4B2O A;  3IB7 A;  4F0Z A;  1OI8 A;  2HYO A;  5JJT A;  4ZVZ A;  1OIE A;  3H63 A;  4KKZ A;  3H60 A;  2USH A;  4UT3 B;  3H67 A;  4OR9 A;  3RL5 A;  4O4K A;  1WAO 1;  3K7V C;  2CV9 A;  3H69 A;  4YKE A;  3N5U A;  1USH A;  3C9F A;  3QG5 C;  3H68 A;  4DT2 A;  3TGH A;  1UF3 A;  3IVD A;  1S3M A;  3H64 A;  4G9J A;  3AUZ A;  4JA7 A;  4MOV A;  4LTY A;  1AUI A;  1T71 A;  1U32 A;  3DW8 C;  4FCX A;  4FBQ A;  4UWQ A;  2BQ8 X;  3ZTV A;  2P6B A;  1T70 A;  4V0X A;  4DHL A;  3QFO A;  5F3W A;  4IL1 A;  3QFN A;  1Z2X A;  3E7A A;  4I5L C;  5DNY A;  2JOG A;  2IE3 C;  4WWL A;  2HYP A;  4FBW A;  3THN A;  3K7W C;  2QFR A;  1KBP A;  3QFM A;  4I5N C;  3RQZ A;  1Z2W A;  2R17 A;  2WDC A;  1II7 A;  2Q8U A;  4O43 A;  2KKN A;  1HPU A;  4LU9 A;  1NNW A;  1V73 A;  1WAR A;  5GTU A;  2NPP C;  4NZV A;  5JPE A;  4H2B A;  1G5B A;  3FGA C;  3C5W C; 
#chains in the Genus database with same CATH topology
 3T1I A;  4MP0 A;  2AHD A;  1JK7 A;  2WDE A;  3D03 A;  4ZX2 A;  1TCO A;  2WDF A;  2BDX A;  2QJC A;  2YVT A;  4DSY A;  3H62 B;  4H1Y P;  3CK2 A;  4UT2 A;  2O8G A;  1XZW A;  3EGH A;  3DSC A;  4TUG A;  1SU1 A;  1S70 A;  2DFJ A;  2WDD A;  3P71 C;  1W24 A;  3IB8 A;  2NYM C;  1S3L A;  3E0J A;  2ZBM A;  2A22 A;  3H66 A;  4IYP C;  2XMO A;  1M63 A;  4H2I A;  5HPE A;  2O8A A;  4O5G A;  5EQV A;  4J6O A;  4LAC C;  2GJU A;  3IVE A;  3E7B A;  2IE4 C;  2QFP A;  4JA9 A;  3JYF A;  5C1V A;  4H2G A;  5JPF A;  1MF8 A;  3THO B;  4ORB A;  1FJM A;  3HVQ A;  3H61 A;  3DSD A;  5B8I A;  2Z72 A;  2HY1 A;  2Z06 A;  4H2F A;  1OID A;  1QHW A;  2IAE C;  4V0W A;  4ORA A;  2BCD A;  2NYL C;  1UTE A;  3AV0 A;  4HD0 A;  1IT6 A;  3ICF A;  3GVE A;  2Z1A A;  4V0V A;  1QFC A;  3V4Y A;  2DXN A;  3ZU0 A;  3RL4 A;  1S3N A;  1S8E A;  4H1S A;  4XPN A;  4UT3 A;  4FBK A;  5INB A;  2NXF A;  1HP1 A;  3PSN A;  1XM7 A;  4TUI A;  4KBP A;  3QFK A;  3LL8 A;  4M0V A;  1HO5 A;  3RL3 A;  5IOH A;  4MOY A;  4Q7F A;  4ORC A;  3KBP A;  4O24 A;  3PSO A;  5J28 A;  3EGG A;  1S95 A;  4B2O A;  3IB7 A;  4F0Z A;  1OI8 A;  2HYO A;  5JJT A;  4ZVZ A;  1OIE A;  3H63 A;  4KKZ A;  3H60 A;  2USH A;  4UT3 B;  3H67 A;  4OR9 A;  3RL5 A;  4O4K A;  1WAO 1;  3K7V C;  2CV9 A;  3H69 A;  4YKE A;  2DXL A;  3N5U A;  1USH A;  3C9F A;  3QG5 C;  3H68 A;  4DT2 A;  3TGH A;  1UF3 A;  3IVD A;  1S3M A;  3H64 A;  4G9J A;  3AUZ A;  4JA7 A;  4MOV A;  4LTY A;  1AUI A;  1T71 A;  1U32 A;  3DW8 C;  4FCX A;  4FBQ A;  4UWQ A;  2BQ8 X;  3ZTV A;  2P6B A;  1T70 A;  4V0X A;  4DHL A;  3QFO A;  5F3W A;  4IL1 A;  3QFN A;  1Z2X A;  3E7A A;  4I5L C;  3FLO A;  5DNY A;  2ZO9 B;  2JOG A;  2IE3 C;  4WWL A;  2HYP A;  4FBW A;  2YEQ A;  3THN A;  3K7W C;  2QFR A;  2ZOA A;  1KBP A;  3QFM A;  4I5N C;  3RQZ A;  1Z2W A;  2R17 A;  2WDC A;  1II7 A;  2Q8U A;  4O43 A;  2KKN A;  1HPU A;  4LU9 A;  1NNW A;  1V73 A;  1WAR A;  5GTU A;  2NPP C;  4NZV A;  5JPE A;  4H2B A;  1G5B A;  3FGA C;  3C5W C; 
#chains in the Genus database with same CATH homology
 3T1I A;  4MP0 A;  2AHD A;  1JK7 A;  2WDE A;  3D03 A;  4ZX2 A;  1TCO A;  2WDF A;  2BDX A;  2QJC A;  2YVT A;  4DSY A;  3H62 B;  4H1Y P;  3CK2 A;  4UT2 A;  2O8G A;  1XZW A;  3EGH A;  3DSC A;  4TUG A;  1SU1 A;  1S70 A;  2DFJ A;  2WDD A;  3P71 C;  1W24 A;  3IB8 A;  2NYM C;  1S3L A;  3E0J A;  2ZBM A;  2A22 A;  3H66 A;  4IYP C;  2XMO A;  1M63 A;  4H2I A;  5HPE A;  2O8A A;  4O5G A;  5EQV A;  4J6O A;  4LAC C;  2GJU A;  3IVE A;  3E7B A;  2IE4 C;  2QFP A;  4JA9 A;  3JYF A;  5C1V A;  4H2G A;  5JPF A;  1MF8 A;  3THO B;  4ORB A;  1FJM A;  3HVQ A;  3H61 A;  3DSD A;  5B8I A;  2Z72 A;  2HY1 A;  2Z06 A;  4H2F A;  1OID A;  1QHW A;  2IAE C;  4V0W A;  4ORA A;  2BCD A;  2NYL C;  1UTE A;  3AV0 A;  4HD0 A;  1IT6 A;  3ICF A;  3GVE A;  2Z1A A;  4V0V A;  1QFC A;  3V4Y A;  2DXN A;  3ZU0 A;  3RL4 A;  1S3N A;  1S8E A;  4H1S A;  4XPN A;  4UT3 A;  4FBK A;  5INB A;  2NXF A;  1HP1 A;  3PSN A;  1XM7 A;  4TUI A;  4KBP A;  3QFK A;  3LL8 A;  4M0V A;  1HO5 A;  3RL3 A;  5IOH A;  4MOY A;  4Q7F A;  4ORC A;  3KBP A;  4O24 A;  3PSO A;  5J28 A;  3EGG A;  1S95 A;  4B2O A;  3IB7 A;  4F0Z A;  1OI8 A;  2HYO A;  5JJT A;  4ZVZ A;  1OIE A;  3H63 A;  4KKZ A;  3H60 A;  2USH A;  4UT3 B;  3H67 A;  4OR9 A;  3RL5 A;  4O4K A;  1WAO 1;  3K7V C;  2CV9 A;  3H69 A;  4YKE A;  2DXL A;  3N5U A;  1USH A;  3C9F A;  3QG5 C;  3H68 A;  4DT2 A;  3TGH A;  1UF3 A;  3IVD A;  1S3M A;  3H64 A;  4G9J A;  3AUZ A;  4JA7 A;  4MOV A;  4LTY A;  1AUI A;  1T71 A;  1U32 A;  3DW8 C;  4FCX A;  4FBQ A;  4UWQ A;  2BQ8 X;  3ZTV A;  2P6B A;  1T70 A;  4V0X A;  4DHL A;  3QFO A;  5F3W A;  4IL1 A;  3QFN A;  1Z2X A;  3E7A A;  4I5L C;  3FLO A;  5DNY A;  2ZO9 B;  2JOG A;  2IE3 C;  4WWL A;  2HYP A;  4FBW A;  2YEQ A;  3THN A;  3K7W C;  2QFR A;  2ZOA A;  1KBP A;  3QFM A;  4I5N C;  3RQZ A;  1Z2W A;  2R17 A;  2WDC A;  1II7 A;  2Q8U A;  4O43 A;  2KKN A;  1HPU A;  4LU9 A;  1NNW A;  1V73 A;  1WAR A;  5GTU A;  2NPP C;  4NZV A;  5JPE A;  4H2B A;  1G5B A;  3FGA C;  3C5W C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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