2NYMC

Crystal structure of protein phosphatase 2a (pp2a) with c-terminus truncated catalytic subunit
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Protein Phosphatase 2A Holoenzyme.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Protein phosphatase 2
total genus 88
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-11-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2nymC00
1S70A 1QHWA 3LL8A 1T71A 2IE4C 3T1IA 4I5NC 1HO5A 2WDDA 3E7BA 1NNWA 4H2IA 3K7VC 4ZVZA 2IE3C 4M0VA 4O5GA 5J28A 2BQ8X 1WARA 3EGGA 3H66A 3RL4A 1S3LA 3ZTVA 2GJUA 2QFPA 3RL5A 2O8AA 2JOGA 2NYMC 3E7AA 3THOB 2BCDA 3P71C 5INBA 2Z1AA 3IB7A 2DFJA 3KBPA 2YVTA 4TUIA 1QFCA 1MF8A 1S3NA 5F3WA 3H63A 4H1SA 1USHA 4I5LC 1S95A 4KKZA 3H69A 1UF3A 2WDEA 3PSNA 3DSCA 3DSDA 1HP1A 3N5UA 2QFRA 1OIDA 4H1YP 2BDXA 2HY1A 4B2OA 1SU1A 5C1VA 3GVEA 4ZX2A 3DW8C 1XZWA 4FBQA 2IAEC 4YKEA 4ORBA 4O4KA 3FGAC 3QG5C 4FBWA 4OR9A 2NPPC 4JA9A 4KBPA 4MOYA 5GTUA 2WDCA 2ZBMA 5JJTA 4DHLA 2QJCA 1OIEA 4DSYA 1IT6A 3EGHA 3V4YA 3K7WC 1V73A 1S8EA 1HPUA 1FJMA 4HD0A 1WAO1 4LTYA 3RL3A 3HVQA 4UT3A 2A22A 2HYPA 4MP0A 5DNYA 2Q8UA 4UT2A 4WWLA 4XPNA 4H2BA 3H68A 2Z72A 4H2FA 2USHA 3C5WC 3QFNA 3JYFA 3H67A 4FBKA 3RQZA 4ORAA 2WDFA 4J6OA 3H60A 4TUGA 1TCOA 4UT3B 1Z2WA 2R17A 4O43A 5B8IA 3AUZA 3C9FA 3PSOA 4LACC 5HPEA 1T70A 3THNA 3QFMA 2Z06A 3ICFA 3AV0A 1S3MA 4G9JA 3CK2A 4LU9A 4ORCA 3TGHA 1JK7A 4UWQA 1G5BA 3H61A 4IL1A 4NZVA 3H62B 1M63A 3H64A 2AHDA 3IVEA 4H2GA 2O8GA 4V0XA 4DT2A 2NYLC 3QFKA 1XM7A 5JPEA 5EQVA 4MOVA 2KKNA 1UTEA 2P6BA 2NXFA 3ZU0A 2XMOA 1W24A 2HYOA 4O24A 4F0ZA 2CV9A 1OI8A 1U32A 5JPFA 1Z2XA 4V0VA 4IYPC 4FCXA 1II7A 1KBPA 4Q7FA 3IVDA 3QFOA 3IB8A 1AUIA 4JA7A 5IOHA 4V0WA
chains in the Genus database with same CATH superfamily
1S70A 1QHWA 3LL8A 1T71A 2IE4C 3T1IA 4I5NC 1HO5A 2WDDA 3E7BA 1NNWA 4H2IA 3K7VC 4ZVZA 2IE3C 4M0VA 4O5GA 5J28A 2BQ8X 2ZOAA 1WARA 3EGGA 3H66A 3RL4A 1S3LA 3ZTVA 2GJUA 2QFPA 3RL5A 2O8AA 2JOGA 2NYMC 3E7AA 3THOB 2BCDA 3P71C 5INBA 2Z1AA 3IB7A 2DFJA 3KBPA 2YVTA 4TUIA 1QFCA 1MF8A 1S3NA 5F3WA 3H63A 4H1SA 1USHA 4I5LC 1S95A 4KKZA 3H69A 1UF3A 2WDEA 2DXLA 3PSNA 3DSCA 3DSDA 1HP1A 3N5UA 2QFRA 1OIDA 4H1YP 2BDXA 2ZO9B 2HY1A 4B2OA 1SU1A 5C1VA 3GVEA 4ZX2A 3DW8C 1XZWA 4FBQA 2IAEC 4YKEA 3D03A 4ORBA 4O4KA 3FGAC 3FLOA 3QG5C 4FBWA 4OR9A 2NPPC 4JA9A 4KBPA 4MOYA 5GTUA 2WDCA 2ZBMA 5JJTA 4DHLA 2QJCA 1OIEA 4DSYA 1IT6A 3EGHA 3V4YA 3K7WC 1V73A 1S8EA 1HPUA 1FJMA 4HD0A 1WAO1 4LTYA 3RL3A 3HVQA 4UT3A 2A22A 2HYPA 4MP0A 5DNYA 2Q8UA 4UT2A 4WWLA 4XPNA 4H2BA 3H68A 2Z72A 4H2FA 2USHA 3C5WC 3QFNA 3JYFA 3H67A 4FBKA 3RQZA 4ORAA 2WDFA 4J6OA 3H60A 4TUGA 1TCOA 2YEQA 4UT3B 1Z2WA 2R17A 4O43A 5B8IA 3AUZA 3C9FA 3PSOA 4LACC 5HPEA 1T70A 3THNA 3QFMA 2Z06A 2DXNA 3ICFA 3AV0A 1S3MA 4G9JA 3E0JA 3CK2A 4LU9A 4ORCA 3TGHA 1JK7A 4UWQA 1G5BA 3H61A 4IL1A 4NZVA 3H62B 1M63A 3H64A 2AHDA 3IVEA 4H2GA 2O8GA 4V0XA 4DT2A 2NYLC 3QFKA 1XM7A 5JPEA 5EQVA 4MOVA 2KKNA 1UTEA 2P6BA 2NXFA 3ZU0A 2XMOA 1W24A 2HYOA 4O24A 4F0ZA 2CV9A 1OI8A 1U32A 5JPFA 1Z2XA 4V0VA 4IYPC 4FCXA 1II7A 1KBPA 4Q7FA 3IVDA 3QFOA 3IB8A 1AUIA 4JA7A 5IOHA 4V0WA
chains in the Genus database with same CATH topology
1S70A 1QHWA 3LL8A 1T71A 2IE4C 3T1IA 4I5NC 1HO5A 2WDDA 3E7BA 1NNWA 4H2IA 3K7VC 4ZVZA 2IE3C 4M0VA 4O5GA 5J28A 2BQ8X 2ZOAA 1WARA 3EGGA 3H66A 3RL4A 1S3LA 3ZTVA 2GJUA 2QFPA 3RL5A 2O8AA 2JOGA 2NYMC 3E7AA 3THOB 2BCDA 3P71C 5INBA 2Z1AA 3IB7A 2DFJA 3KBPA 2YVTA 4TUIA 1QFCA 1MF8A 1S3NA 5F3WA 3H63A 4H1SA 1USHA 4I5LC 1S95A 4KKZA 3H69A 1UF3A 2WDEA 2DXLA 3PSNA 3DSCA 3DSDA 1HP1A 3N5UA 2QFRA 1OIDA 4H1YP 2BDXA 2ZO9B 2HY1A 4B2OA 1SU1A 5C1VA 3GVEA 4ZX2A 3DW8C 1XZWA 4FBQA 2IAEC 4YKEA 3D03A 4ORBA 4O4KA 3FGAC 3FLOA 3QG5C 4FBWA 4OR9A 2NPPC 4JA9A 4KBPA 4MOYA 5GTUA 2WDCA 2ZBMA 5JJTA 4DHLA 2QJCA 1OIEA 4DSYA 1IT6A 3EGHA 3V4YA 3K7WC 1V73A 1S8EA 1HPUA 1FJMA 4HD0A 1WAO1 4LTYA 3RL3A 3HVQA 4UT3A 2A22A 2HYPA 4MP0A 5DNYA 2Q8UA 4UT2A 4WWLA 4XPNA 4H2BA 3H68A 2Z72A 4H2FA 2USHA 3C5WC 3QFNA 3JYFA 3H67A 4FBKA 3RQZA 4ORAA 2WDFA 4J6OA 3H60A 4TUGA 1TCOA 2YEQA 4UT3B 1Z2WA 2R17A 4O43A 5B8IA 3AUZA 3C9FA 3PSOA 4LACC 5HPEA 1T70A 3THNA 3QFMA 2Z06A 2DXNA 3ICFA 3AV0A 1S3MA 4G9JA 3E0JA 3CK2A 4LU9A 4ORCA 3TGHA 1JK7A 4UWQA 1G5BA 3H61A 4IL1A 4NZVA 3H62B 1M63A 3H64A 2AHDA 3IVEA 4H2GA 2O8GA 4V0XA 4DT2A 2NYLC 3QFKA 1XM7A 5JPEA 5EQVA 4MOVA 2KKNA 1UTEA 2P6BA 2NXFA 3ZU0A 2XMOA 1W24A 2HYOA 4O24A 4F0ZA 2CV9A 1OI8A 1U32A 5JPFA 1Z2XA 4V0VA 4IYPC 4FCXA 1II7A 1KBPA 4Q7FA 3IVDA 3QFOA 3IB8A 1AUIA 4JA7A 5IOHA 4V0WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S70 A;  1QHW A;  3LL8 A;  1T71 A;  2IE4 C;  3T1I A;  4I5N C;  1HO5 A;  2WDD A;  3E7B A;  1NNW A;  4H2I A;  3K7V C;  4ZVZ A;  2IE3 C;  4M0V A;  4O5G A;  5J28 A;  2BQ8 X;  1WAR A;  3EGG A;  3H66 A;  3RL4 A;  1S3L A;  3ZTV A;  2GJU A;  2QFP A;  3RL5 A;  2O8A A;  2JOG A;  2NYM C;  3E7A A;  3THO B;  2BCD A;  3P71 C;  5INB A;  2Z1A A;  3IB7 A;  2DFJ A;  3KBP A;  2YVT A;  4TUI A;  1QFC A;  1MF8 A;  1S3N A;  5F3W A;  3H63 A;  4H1S A;  1USH A;  4I5L C;  1S95 A;  4KKZ A;  3H69 A;  1UF3 A;  2WDE A;  3PSN A;  3DSC A;  3DSD A;  1HP1 A;  3N5U A;  2QFR A;  1OID A;  4H1Y P;  2BDX A;  2HY1 A;  4B2O A;  1SU1 A;  5C1V A;  3GVE A;  4ZX2 A;  3DW8 C;  1XZW A;  4FBQ A;  2IAE C;  4YKE A;  4ORB A;  4O4K A;  3FGA C;  3QG5 C;  4FBW A;  4OR9 A;  2NPP C;  4JA9 A;  4KBP A;  4MOY A;  5GTU A;  2WDC A;  2ZBM A;  5JJT A;  4DHL A;  2QJC A;  1OIE A;  4DSY A;  1IT6 A;  3EGH A;  3V4Y A;  3K7W C;  1V73 A;  1S8E A;  1HPU A;  1FJM A;  4HD0 A;  1WAO 1;  4LTY A;  3RL3 A;  3HVQ A;  4UT3 A;  2A22 A;  2HYP A;  4MP0 A;  5DNY A;  2Q8U A;  4UT2 A;  4WWL A;  4XPN A;  4H2B A;  3H68 A;  2Z72 A;  4H2F A;  2USH A;  3C5W C;  3QFN A;  3JYF A;  3H67 A;  4FBK A;  3RQZ A;  4ORA A;  2WDF A;  4J6O A;  3H60 A;  4TUG A;  1TCO A;  4UT3 B;  1Z2W A;  2R17 A;  4O43 A;  5B8I A;  3AUZ A;  3C9F A;  3PSO A;  4LAC C;  5HPE A;  1T70 A;  3THN A;  3QFM A;  2Z06 A;  3ICF A;  3AV0 A;  1S3M A;  4G9J A;  3CK2 A;  4LU9 A;  4ORC A;  3TGH A;  1JK7 A;  4UWQ A;  1G5B A;  3H61 A;  4IL1 A;  4NZV A;  3H62 B;  1M63 A;  3H64 A;  2AHD A;  3IVE A;  4H2G A;  2O8G A;  4V0X A;  4DT2 A;  2NYL C;  3QFK A;  1XM7 A;  5JPE A;  5EQV A;  4MOV A;  2KKN A;  1UTE A;  2P6B A;  2NXF A;  3ZU0 A;  2XMO A;  1W24 A;  2HYO A;  4O24 A;  4F0Z A;  2CV9 A;  1OI8 A;  1U32 A;  5JPF A;  1Z2X A;  4V0V A;  4IYP C;  4FCX A;  1II7 A;  1KBP A;  4Q7F A;  3IVD A;  3QFO A;  3IB8 A;  1AUI A;  4JA7 A;  5IOH A;  4V0W A; 
#chains in the Genus database with same CATH topology
 1S70 A;  1QHW A;  3LL8 A;  1T71 A;  2IE4 C;  3T1I A;  4I5N C;  1HO5 A;  2WDD A;  3E7B A;  1NNW A;  4H2I A;  3K7V C;  4ZVZ A;  2IE3 C;  4M0V A;  4O5G A;  5J28 A;  2BQ8 X;  2ZOA A;  1WAR A;  3EGG A;  3H66 A;  3RL4 A;  1S3L A;  3ZTV A;  2GJU A;  2QFP A;  3RL5 A;  2O8A A;  2JOG A;  2NYM C;  3E7A A;  3THO B;  2BCD A;  3P71 C;  5INB A;  2Z1A A;  3IB7 A;  2DFJ A;  3KBP A;  2YVT A;  4TUI A;  1QFC A;  1MF8 A;  1S3N A;  5F3W A;  3H63 A;  4H1S A;  1USH A;  4I5L C;  1S95 A;  4KKZ A;  3H69 A;  1UF3 A;  2WDE A;  2DXL A;  3PSN A;  3DSC A;  3DSD A;  1HP1 A;  3N5U A;  2QFR A;  1OID A;  4H1Y P;  2BDX A;  2ZO9 B;  2HY1 A;  4B2O A;  1SU1 A;  5C1V A;  3GVE A;  4ZX2 A;  3DW8 C;  1XZW A;  4FBQ A;  2IAE C;  4YKE A;  3D03 A;  4ORB A;  4O4K A;  3FGA C;  3FLO A;  3QG5 C;  4FBW A;  4OR9 A;  2NPP C;  4JA9 A;  4KBP A;  4MOY A;  5GTU A;  2WDC A;  2ZBM A;  5JJT A;  4DHL A;  2QJC A;  1OIE A;  4DSY A;  1IT6 A;  3EGH A;  3V4Y A;  3K7W C;  1V73 A;  1S8E A;  1HPU A;  1FJM A;  4HD0 A;  1WAO 1;  4LTY A;  3RL3 A;  3HVQ A;  4UT3 A;  2A22 A;  2HYP A;  4MP0 A;  5DNY A;  2Q8U A;  4UT2 A;  4WWL A;  4XPN A;  4H2B A;  3H68 A;  2Z72 A;  4H2F A;  2USH A;  3C5W C;  3QFN A;  3JYF A;  3H67 A;  4FBK A;  3RQZ A;  4ORA A;  2WDF A;  4J6O A;  3H60 A;  4TUG A;  1TCO A;  2YEQ A;  4UT3 B;  1Z2W A;  2R17 A;  4O43 A;  5B8I A;  3AUZ A;  3C9F A;  3PSO A;  4LAC C;  5HPE A;  1T70 A;  3THN A;  3QFM A;  2Z06 A;  2DXN A;  3ICF A;  3AV0 A;  1S3M A;  4G9J A;  3E0J A;  3CK2 A;  4LU9 A;  4ORC A;  3TGH A;  1JK7 A;  4UWQ A;  1G5B A;  3H61 A;  4IL1 A;  4NZV A;  3H62 B;  1M63 A;  3H64 A;  2AHD A;  3IVE A;  4H2G A;  2O8G A;  4V0X A;  4DT2 A;  2NYL C;  3QFK A;  1XM7 A;  5JPE A;  5EQV A;  4MOV A;  2KKN A;  1UTE A;  2P6B A;  2NXF A;  3ZU0 A;  2XMO A;  1W24 A;  2HYO A;  4O24 A;  4F0Z A;  2CV9 A;  1OI8 A;  1U32 A;  5JPF A;  1Z2X A;  4V0V A;  4IYP C;  4FCX A;  1II7 A;  1KBP A;  4Q7F A;  3IVD A;  3QFO A;  3IB8 A;  1AUI A;  4JA7 A;  5IOH A;  4V0W A; 
#chains in the Genus database with same CATH homology
 1S70 A;  1QHW A;  3LL8 A;  1T71 A;  2IE4 C;  3T1I A;  4I5N C;  1HO5 A;  2WDD A;  3E7B A;  1NNW A;  4H2I A;  3K7V C;  4ZVZ A;  2IE3 C;  4M0V A;  4O5G A;  5J28 A;  2BQ8 X;  2ZOA A;  1WAR A;  3EGG A;  3H66 A;  3RL4 A;  1S3L A;  3ZTV A;  2GJU A;  2QFP A;  3RL5 A;  2O8A A;  2JOG A;  2NYM C;  3E7A A;  3THO B;  2BCD A;  3P71 C;  5INB A;  2Z1A A;  3IB7 A;  2DFJ A;  3KBP A;  2YVT A;  4TUI A;  1QFC A;  1MF8 A;  1S3N A;  5F3W A;  3H63 A;  4H1S A;  1USH A;  4I5L C;  1S95 A;  4KKZ A;  3H69 A;  1UF3 A;  2WDE A;  2DXL A;  3PSN A;  3DSC A;  3DSD A;  1HP1 A;  3N5U A;  2QFR A;  1OID A;  4H1Y P;  2BDX A;  2ZO9 B;  2HY1 A;  4B2O A;  1SU1 A;  5C1V A;  3GVE A;  4ZX2 A;  3DW8 C;  1XZW A;  4FBQ A;  2IAE C;  4YKE A;  3D03 A;  4ORB A;  4O4K A;  3FGA C;  3FLO A;  3QG5 C;  4FBW A;  4OR9 A;  2NPP C;  4JA9 A;  4KBP A;  4MOY A;  5GTU A;  2WDC A;  2ZBM A;  5JJT A;  4DHL A;  2QJC A;  1OIE A;  4DSY A;  1IT6 A;  3EGH A;  3V4Y A;  3K7W C;  1V73 A;  1S8E A;  1HPU A;  1FJM A;  4HD0 A;  1WAO 1;  4LTY A;  3RL3 A;  3HVQ A;  4UT3 A;  2A22 A;  2HYP A;  4MP0 A;  5DNY A;  2Q8U A;  4UT2 A;  4WWL A;  4XPN A;  4H2B A;  3H68 A;  2Z72 A;  4H2F A;  2USH A;  3C5W C;  3QFN A;  3JYF A;  3H67 A;  4FBK A;  3RQZ A;  4ORA A;  2WDF A;  4J6O A;  3H60 A;  4TUG A;  1TCO A;  2YEQ A;  4UT3 B;  1Z2W A;  2R17 A;  4O43 A;  5B8I A;  3AUZ A;  3C9F A;  3PSO A;  4LAC C;  5HPE A;  1T70 A;  3THN A;  3QFM A;  2Z06 A;  2DXN A;  3ICF A;  3AV0 A;  1S3M A;  4G9J A;  3E0J A;  3CK2 A;  4LU9 A;  4ORC A;  3TGH A;  1JK7 A;  4UWQ A;  1G5B A;  3H61 A;  4IL1 A;  4NZV A;  3H62 B;  1M63 A;  3H64 A;  2AHD A;  3IVE A;  4H2G A;  2O8G A;  4V0X A;  4DT2 A;  2NYL C;  3QFK A;  1XM7 A;  5JPE A;  5EQV A;  4MOV A;  2KKN A;  1UTE A;  2P6B A;  2NXF A;  3ZU0 A;  2XMO A;  1W24 A;  2HYO A;  4O24 A;  4F0Z A;  2CV9 A;  1OI8 A;  1U32 A;  5JPF A;  1Z2X A;  4V0V A;  4IYP C;  4FCX A;  1II7 A;  1KBP A;  4Q7F A;  3IVD A;  3QFO A;  3IB8 A;  1AUI A;  4JA7 A;  5IOH A;  4V0W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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