2P6BA

Crystal structure of human calcineurin in complex with pvivit peptide
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
357
structure length
357
Chain Sequence
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
pubmed doi rcsb
molecule tags Hydrolase/hydrolase regulator
source organism Homo sapiens
molecule keywords PVIVIT 14-mer Peptide
total genus 127
structure length 357
sequence length 357
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2007-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2p6bA00
4ORBA 2O8AA 2ZBMA 3H61A 2WDCA 3RL3A 5INBA 2HY1A 4MOVA 3GVEA 4V0XA 1QHWA 4UWQA 5DNYA 3QFNA 3KBPA 3P71C 1S8EA 4KBPA 4FCXA 4TUIA 4H1YP 4V0WA 4FBWA 1S3MA 5F3WA 4O24A 4HD0A 1XZWA 1S95A 2Z06A 2IE4C 2GJUA 1UF3A 3THOB 2XMOA 1USHA 3V4YA 2Z72A 2WDEA 4XPNA 4B2OA 1T70A 1NNWA 2R17A 2BQ8X 4DSYA 3HVQA 3AUZA 1OIDA 4J6OA 5HPEA 4WWLA 3T1IA 3RL4A 4DT2A 3IVEA 2NPPC 4TUGA 3LL8A 4O5GA 4O43A 1V73A 4I5NC 4V0VA 3RQZA 3K7WC 2CV9A 4UT3A 3DSCA 3JYFA 4OR9A 1XM7A 3QG5C 4H1SA 2IAEC 1HO5A 2QFPA 2DFJA 2BCDA 3IVDA 2HYOA 1S70A 3QFOA 1II7A 1M63A 2BDXA 2KKNA 4ORCA 1UTEA 1TCOA 2WDDA 3ZTVA 5J28A 3N5UA 2QFRA 3IB8A 3H66A 3H62B 4IYPC 1G5BA 3H63A 1U32A 3C9FA 2Q8UA 3QFKA 3ICFA 4MOYA 3RL5A 4H2GA 3AV0A 3H64A 4KKZA 1Z2WA 1IT6A 4MP0A 4UT3B 2QJCA 3CK2A 1QFCA 4ZX2A 4H2IA 3FGAC 1FJMA 3ZU0A 3H69A 1MF8A 3H68A 4LTYA 3PSOA 5JPFA 2IE3C 2Z1AA 4H2FA 3PSNA 3EGHA 1OIEA 4LU9A 2YVTA 3QFMA 5GTUA 1T71A 4FBKA 1SU1A 5IOHA 1S3LA 1S3NA 4UT2A 4FBQA 4YKEA 1KBPA 3DSDA 2NYMC 4F0ZA 1AUIA 1OI8A 4O4KA 2JOGA 2NXFA 4Q7FA 5EQVA 5C1VA 1Z2XA 3C5WC 2WDFA 3EGGA 4LACC 1HPUA 4ZVZA 5JPEA 1JK7A 2O8GA 3H67A 4ORAA 3E7AA 4H2BA 4JA9A 3IB7A 3E7BA 5B8IA 3THNA 4JA7A 2A22A 2USHA 2NYLC 4G9JA 4IL1A 2AHDA 1WARA 2P6BA 3DW8C 4M0VA 3K7VC 4NZVA 1WAO1 4I5LC 2HYPA 1HP1A 5JJTA 3TGHA 4DHLA 3H60A 1W24A
chains in the Genus database with same CATH superfamily
4ORBA 2O8AA 2ZBMA 3H61A 2WDCA 3RL3A 5INBA 2HY1A 4MOVA 3GVEA 4V0XA 1QHWA 4UWQA 5DNYA 3QFNA 3KBPA 3P71C 1S8EA 4KBPA 4FCXA 4TUIA 4H1YP 4V0WA 4FBWA 1S3MA 2DXNA 5F3WA 4O24A 4HD0A 1XZWA 1S95A 2Z06A 2IE4C 2GJUA 1UF3A 3THOB 2XMOA 1USHA 3V4YA 2Z72A 2WDEA 4XPNA 4B2OA 1T70A 1NNWA 2R17A 2BQ8X 4DSYA 3HVQA 3AUZA 1OIDA 4J6OA 5HPEA 4WWLA 3T1IA 3RL4A 4DT2A 3IVEA 2NPPC 4TUGA 3LL8A 4O5GA 4O43A 1V73A 4I5NC 4V0VA 3RQZA 3K7WC 2CV9A 4UT3A 2YEQA 3DSCA 3JYFA 4OR9A 1XM7A 3QG5C 4H1SA 2IAEC 1HO5A 2QFPA 2DFJA 2BCDA 3IVDA 2HYOA 1S70A 3QFOA 1II7A 1M63A 2BDXA 2KKNA 4ORCA 1UTEA 1TCOA 2WDDA 3ZTVA 5J28A 3N5UA 2QFRA 3IB8A 3H66A 3H62B 4IYPC 1G5BA 3H63A 1U32A 3C9FA 2Q8UA 3QFKA 3ICFA 4MOYA 3RL5A 4H2GA 3AV0A 3H64A 3E0JA 4KKZA 1Z2WA 1IT6A 4MP0A 4UT3B 3FLOA 2QJCA 3CK2A 1QFCA 4ZX2A 4H2IA 3FGAC 1FJMA 3ZU0A 3H69A 1MF8A 3H68A 4LTYA 3PSOA 5JPFA 2IE3C 2Z1AA 4H2FA 3PSNA 3EGHA 1OIEA 3D03A 2ZOAA 4LU9A 2YVTA 3QFMA 5GTUA 1T71A 4FBKA 1SU1A 5IOHA 1S3LA 1S3NA 4UT2A 4FBQA 4YKEA 1KBPA 3DSDA 2NYMC 4F0ZA 1AUIA 1OI8A 4O4KA 2JOGA 2NXFA 4Q7FA 5EQVA 5C1VA 1Z2XA 3C5WC 2WDFA 3EGGA 4LACC 1HPUA 4ZVZA 5JPEA 1JK7A 2O8GA 3H67A 4ORAA 3E7AA 4H2BA 4JA9A 3IB7A 3E7BA 5B8IA 3THNA 4JA7A 2A22A 2USHA 2NYLC 2DXLA 4G9JA 4IL1A 2AHDA 1WARA 2P6BA 3DW8C 4M0VA 3K7VC 4NZVA 1WAO1 4I5LC 2HYPA 1HP1A 5JJTA 3TGHA 2ZO9B 3H60A 4DHLA 1W24A
chains in the Genus database with same CATH topology
4ORBA 2O8AA 2ZBMA 3H61A 2WDCA 3RL3A 5INBA 2HY1A 4MOVA 3GVEA 4V0XA 1QHWA 4UWQA 5DNYA 3QFNA 3KBPA 3P71C 1S8EA 4KBPA 4FCXA 4TUIA 4H1YP 4V0WA 4FBWA 1S3MA 2DXNA 5F3WA 4O24A 4HD0A 1XZWA 1S95A 2Z06A 2IE4C 2GJUA 1UF3A 3THOB 2XMOA 1USHA 3V4YA 2Z72A 2WDEA 4XPNA 4B2OA 1T70A 1NNWA 2R17A 2BQ8X 4DSYA 3HVQA 3AUZA 1OIDA 4J6OA 5HPEA 4WWLA 3T1IA 3RL4A 4DT2A 3IVEA 2NPPC 4TUGA 3LL8A 4O5GA 4O43A 1V73A 4I5NC 4V0VA 3RQZA 3K7WC 2CV9A 4UT3A 2YEQA 3DSCA 3JYFA 4OR9A 1XM7A 3QG5C 4H1SA 2IAEC 1HO5A 2QFPA 2DFJA 2BCDA 3IVDA 2HYOA 1S70A 3QFOA 1II7A 1M63A 2BDXA 2KKNA 4ORCA 1UTEA 1TCOA 2WDDA 3ZTVA 5J28A 3N5UA 2QFRA 3IB8A 3H66A 3H62B 4IYPC 1G5BA 3H63A 1U32A 3C9FA 2Q8UA 3QFKA 3ICFA 4MOYA 3RL5A 4H2GA 3AV0A 3H64A 3E0JA 4KKZA 1Z2WA 1IT6A 4MP0A 4UT3B 3FLOA 2QJCA 3CK2A 1QFCA 4ZX2A 4H2IA 3FGAC 1FJMA 3ZU0A 3H69A 1MF8A 3H68A 4LTYA 3PSOA 5JPFA 2IE3C 2Z1AA 4H2FA 3PSNA 3EGHA 1OIEA 3D03A 2ZOAA 4LU9A 2YVTA 3QFMA 5GTUA 1T71A 4FBKA 1SU1A 5IOHA 1S3LA 1S3NA 4UT2A 4FBQA 4YKEA 1KBPA 3DSDA 2NYMC 4F0ZA 1AUIA 1OI8A 4O4KA 2JOGA 2NXFA 4Q7FA 5EQVA 5C1VA 1Z2XA 3C5WC 2WDFA 3EGGA 4LACC 1HPUA 4ZVZA 5JPEA 1JK7A 2O8GA 3H67A 4ORAA 3E7AA 4H2BA 4JA9A 3IB7A 3E7BA 5B8IA 3THNA 4JA7A 2A22A 2USHA 2NYLC 2DXLA 4G9JA 4IL1A 2AHDA 1WARA 2P6BA 3DW8C 4M0VA 3K7VC 4NZVA 1WAO1 4I5LC 2HYPA 1HP1A 5JJTA 3TGHA 2ZO9B 3H60A 4DHLA 1W24A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ORB A;  2O8A A;  2ZBM A;  3H61 A;  2WDC A;  3RL3 A;  5INB A;  2HY1 A;  4MOV A;  3GVE A;  4V0X A;  1QHW A;  4UWQ A;  5DNY A;  3QFN A;  3KBP A;  3P71 C;  1S8E A;  4KBP A;  4FCX A;  4TUI A;  4H1Y P;  4V0W A;  4FBW A;  1S3M A;  5F3W A;  4O24 A;  4HD0 A;  1XZW A;  1S95 A;  2Z06 A;  2IE4 C;  2GJU A;  1UF3 A;  3THO B;  2XMO A;  1USH A;  3V4Y A;  2Z72 A;  2WDE A;  4XPN A;  4B2O A;  1T70 A;  1NNW A;  2R17 A;  2BQ8 X;  4DSY A;  3HVQ A;  3AUZ A;  1OID A;  4J6O A;  5HPE A;  4WWL A;  3T1I A;  3RL4 A;  4DT2 A;  3IVE A;  2NPP C;  4TUG A;  3LL8 A;  4O5G A;  4O43 A;  1V73 A;  4I5N C;  4V0V A;  3RQZ A;  3K7W C;  2CV9 A;  4UT3 A;  3DSC A;  3JYF A;  4OR9 A;  1XM7 A;  3QG5 C;  4H1S A;  2IAE C;  1HO5 A;  2QFP A;  2DFJ A;  2BCD A;  3IVD A;  2HYO A;  1S70 A;  3QFO A;  1II7 A;  1M63 A;  2BDX A;  2KKN A;  4ORC A;  1UTE A;  1TCO A;  2WDD A;  3ZTV A;  5J28 A;  3N5U A;  2QFR A;  3IB8 A;  3H66 A;  3H62 B;  4IYP C;  1G5B A;  3H63 A;  1U32 A;  3C9F A;  2Q8U A;  3QFK A;  3ICF A;  4MOY A;  3RL5 A;  4H2G A;  3AV0 A;  3H64 A;  4KKZ A;  1Z2W A;  1IT6 A;  4MP0 A;  4UT3 B;  2QJC A;  3CK2 A;  1QFC A;  4ZX2 A;  4H2I A;  3FGA C;  1FJM A;  3ZU0 A;  3H69 A;  1MF8 A;  3H68 A;  4LTY A;  3PSO A;  5JPF A;  2IE3 C;  2Z1A A;  4H2F A;  3PSN A;  3EGH A;  1OIE A;  4LU9 A;  2YVT A;  3QFM A;  5GTU A;  1T71 A;  4FBK A;  1SU1 A;  5IOH A;  1S3L A;  1S3N A;  4UT2 A;  4FBQ A;  4YKE A;  1KBP A;  3DSD A;  2NYM C;  4F0Z A;  1AUI A;  1OI8 A;  4O4K A;  2JOG A;  2NXF A;  4Q7F A;  5EQV A;  5C1V A;  1Z2X A;  3C5W C;  2WDF A;  3EGG A;  4LAC C;  1HPU A;  4ZVZ A;  5JPE A;  1JK7 A;  2O8G A;  3H67 A;  4ORA A;  3E7A A;  4H2B A;  4JA9 A;  3IB7 A;  3E7B A;  5B8I A;  3THN A;  4JA7 A;  2A22 A;  2USH A;  2NYL C;  4G9J A;  4IL1 A;  2AHD A;  1WAR A;  2P6B A;  3DW8 C;  4M0V A;  3K7V C;  4NZV A;  1WAO 1;  4I5L C;  2HYP A;  1HP1 A;  5JJT A;  3TGH A;  4DHL A;  3H60 A;  1W24 A; 
#chains in the Genus database with same CATH topology
 4ORB A;  2O8A A;  2ZBM A;  3H61 A;  2WDC A;  3RL3 A;  5INB A;  2HY1 A;  4MOV A;  3GVE A;  4V0X A;  1QHW A;  4UWQ A;  5DNY A;  3QFN A;  3KBP A;  3P71 C;  1S8E A;  4KBP A;  4FCX A;  4TUI A;  4H1Y P;  4V0W A;  4FBW A;  1S3M A;  2DXN A;  5F3W A;  4O24 A;  4HD0 A;  1XZW A;  1S95 A;  2Z06 A;  2IE4 C;  2GJU A;  1UF3 A;  3THO B;  2XMO A;  1USH A;  3V4Y A;  2Z72 A;  2WDE A;  4XPN A;  4B2O A;  1T70 A;  1NNW A;  2R17 A;  2BQ8 X;  4DSY A;  3HVQ A;  3AUZ A;  1OID A;  4J6O A;  5HPE A;  4WWL A;  3T1I A;  3RL4 A;  4DT2 A;  3IVE A;  2NPP C;  4TUG A;  3LL8 A;  4O5G A;  4O43 A;  1V73 A;  4I5N C;  4V0V A;  3RQZ A;  3K7W C;  2CV9 A;  4UT3 A;  2YEQ A;  3DSC A;  3JYF A;  4OR9 A;  1XM7 A;  3QG5 C;  4H1S A;  2IAE C;  1HO5 A;  2QFP A;  2DFJ A;  2BCD A;  3IVD A;  2HYO A;  1S70 A;  3QFO A;  1II7 A;  1M63 A;  2BDX A;  2KKN A;  4ORC A;  1UTE A;  1TCO A;  2WDD A;  3ZTV A;  5J28 A;  3N5U A;  2QFR A;  3IB8 A;  3H66 A;  3H62 B;  4IYP C;  1G5B A;  3H63 A;  1U32 A;  3C9F A;  2Q8U A;  3QFK A;  3ICF A;  4MOY A;  3RL5 A;  4H2G A;  3AV0 A;  3H64 A;  3E0J A;  4KKZ A;  1Z2W A;  1IT6 A;  4MP0 A;  4UT3 B;  3FLO A;  2QJC A;  3CK2 A;  1QFC A;  4ZX2 A;  4H2I A;  3FGA C;  1FJM A;  3ZU0 A;  3H69 A;  1MF8 A;  3H68 A;  4LTY A;  3PSO A;  5JPF A;  2IE3 C;  2Z1A A;  4H2F A;  3PSN A;  3EGH A;  1OIE A;  3D03 A;  2ZOA A;  4LU9 A;  2YVT A;  3QFM A;  5GTU A;  1T71 A;  4FBK A;  1SU1 A;  5IOH A;  1S3L A;  1S3N A;  4UT2 A;  4FBQ A;  4YKE A;  1KBP A;  3DSD A;  2NYM C;  4F0Z A;  1AUI A;  1OI8 A;  4O4K A;  2JOG A;  2NXF A;  4Q7F A;  5EQV A;  5C1V A;  1Z2X A;  3C5W C;  2WDF A;  3EGG A;  4LAC C;  1HPU A;  4ZVZ A;  5JPE A;  1JK7 A;  2O8G A;  3H67 A;  4ORA A;  3E7A A;  4H2B A;  4JA9 A;  3IB7 A;  3E7B A;  5B8I A;  3THN A;  4JA7 A;  2A22 A;  2USH A;  2NYL C;  2DXL A;  4G9J A;  4IL1 A;  2AHD A;  1WAR A;  2P6B A;  3DW8 C;  4M0V A;  3K7V C;  4NZV A;  1WAO 1;  4I5L C;  2HYP A;  1HP1 A;  5JJT A;  3TGH A;  2ZO9 B;  3H60 A;  4DHL A;  1W24 A; 
#chains in the Genus database with same CATH homology
 4ORB A;  2O8A A;  2ZBM A;  3H61 A;  2WDC A;  3RL3 A;  5INB A;  2HY1 A;  4MOV A;  3GVE A;  4V0X A;  1QHW A;  4UWQ A;  5DNY A;  3QFN A;  3KBP A;  3P71 C;  1S8E A;  4KBP A;  4FCX A;  4TUI A;  4H1Y P;  4V0W A;  4FBW A;  1S3M A;  2DXN A;  5F3W A;  4O24 A;  4HD0 A;  1XZW A;  1S95 A;  2Z06 A;  2IE4 C;  2GJU A;  1UF3 A;  3THO B;  2XMO A;  1USH A;  3V4Y A;  2Z72 A;  2WDE A;  4XPN A;  4B2O A;  1T70 A;  1NNW A;  2R17 A;  2BQ8 X;  4DSY A;  3HVQ A;  3AUZ A;  1OID A;  4J6O A;  5HPE A;  4WWL A;  3T1I A;  3RL4 A;  4DT2 A;  3IVE A;  2NPP C;  4TUG A;  3LL8 A;  4O5G A;  4O43 A;  1V73 A;  4I5N C;  4V0V A;  3RQZ A;  3K7W C;  2CV9 A;  4UT3 A;  2YEQ A;  3DSC A;  3JYF A;  4OR9 A;  1XM7 A;  3QG5 C;  4H1S A;  2IAE C;  1HO5 A;  2QFP A;  2DFJ A;  2BCD A;  3IVD A;  2HYO A;  1S70 A;  3QFO A;  1II7 A;  1M63 A;  2BDX A;  2KKN A;  4ORC A;  1UTE A;  1TCO A;  2WDD A;  3ZTV A;  5J28 A;  3N5U A;  2QFR A;  3IB8 A;  3H66 A;  3H62 B;  4IYP C;  1G5B A;  3H63 A;  1U32 A;  3C9F A;  2Q8U A;  3QFK A;  3ICF A;  4MOY A;  3RL5 A;  4H2G A;  3AV0 A;  3H64 A;  3E0J A;  4KKZ A;  1Z2W A;  1IT6 A;  4MP0 A;  4UT3 B;  3FLO A;  2QJC A;  3CK2 A;  1QFC A;  4ZX2 A;  4H2I A;  3FGA C;  1FJM A;  3ZU0 A;  3H69 A;  1MF8 A;  3H68 A;  4LTY A;  3PSO A;  5JPF A;  2IE3 C;  2Z1A A;  4H2F A;  3PSN A;  3EGH A;  1OIE A;  3D03 A;  2ZOA A;  4LU9 A;  2YVT A;  3QFM A;  5GTU A;  1T71 A;  4FBK A;  1SU1 A;  5IOH A;  1S3L A;  1S3N A;  4UT2 A;  4FBQ A;  4YKE A;  1KBP A;  3DSD A;  2NYM C;  4F0Z A;  1AUI A;  1OI8 A;  4O4K A;  2JOG A;  2NXF A;  4Q7F A;  5EQV A;  5C1V A;  1Z2X A;  3C5W C;  2WDF A;  3EGG A;  4LAC C;  1HPU A;  4ZVZ A;  5JPE A;  1JK7 A;  2O8G A;  3H67 A;  4ORA A;  3E7A A;  4H2B A;  4JA9 A;  3IB7 A;  3E7B A;  5B8I A;  3THN A;  4JA7 A;  2A22 A;  2USH A;  2NYL C;  2DXL A;  4G9J A;  4IL1 A;  2AHD A;  1WAR A;  2P6B A;  3DW8 C;  4M0V A;  3K7V C;  4NZV A;  1WAO 1;  4I5L C;  2HYP A;  1HP1 A;  5JJT A;  3TGH A;  2ZO9 B;  3H60 A;  4DHL A;  1W24 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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