2R17A

Functional architecture of the retromer cargo-recognition complex
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
183
structure length
183
Chain Sequence
MMLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional architecture of the retromer cargo-recognition complex.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords Vacuolar protein sorting-associated protein 29
total genus 41
structure length 183
sequence length 183
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF12850 Metallophos_2 Calcineurin-like phosphoesterase superfamily domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2r17A00
5EQVA 3T1IA 3K7VC 3ZTVA 3QG5C 1OI8A 3C5WC 1KBPA 3QFMA 4UWQA 4IL1A 2A22A 1MF8A 1M63A 3GVEA 1QFCA 3IB8A 3DSCA 4KBPA 2WDEA 4O4KA 3RL4A 4MOYA 2Z72A 2WDDA 1S8EA 4UT3A 4J6OA 4MP0A 3AV0A 3IVEA 5JJTA 2JOGA 2QFPA 3H63A 3ZU0A 5C1VA 1OIDA 1JK7A 1FJMA 4ORBA 1AUIA 3N5UA 3RL3A 2Q8UA 4O5GA 4V0WA 1Z2WA 4H1SA 3IB7A 3ICFA 3K7WC 1T70A 4H2BA 1W24A 3E7AA 1SU1A 2BDXA 4ORCA 2YVTA 1T71A 1UTEA 4H2GA 4ORAA 3H62B 1HO5A 4G9JA 5JPEA 1U32A 4H2IA 5IOHA 5DNYA 4UT3B 4WWLA 3THOB 5INBA 4HD0A 1S3LA 2NYLC 2GJUA 4DSYA 4B2OA 3E7BA 2WDFA 2NXFA 1UF3A 2P6BA 4FBWA 4Q7FA 3CK2A 4H1YP 3KBPA 4FBQA 2QJCA 4I5NC 3H68A 3QFNA 3H61A 2WDCA 2AHDA 3H64A 4LTYA 1S3NA 2USHA 4JA9A 3RQZA 4TUIA 2Z1AA 3THNA 1S70A 1Z2XA 1V73A 2IE4C 4LACC 4TUGA 4DT2A 4FBKA 5F3WA 5GTUA 2NPPC 3HVQA 4MOVA 1XM7A 4DHLA 1NNWA 3PSNA 1II7A 4IYPC 1S3MA 2Z06A 2CV9A 3V4YA 2DFJA 2O8AA 1TCOA 2HYPA 3AUZA 4M0VA 4F0ZA 4ZX2A 4ZVZA 2KKNA 2R17A 4O43A 3PSOA 4OR9A 5HPEA 5JPFA 1WARA 4V0VA 3RL5A 2HYOA 3IVDA 2NYMC 3DSDA 1XZWA 2BCDA 3EGGA 4LU9A 4FCXA 3H60A 1HP1A 4NZVA 1S95A 3QFOA 2IE3C 4I5LC 3H67A 1G5BA 2ZBMA 4YKEA 5J28A 3C9FA 3P71C 5B8IA 4JA7A 2IAEC 3EGHA 3FGAC 3H66A 3LL8A 4XPNA 4KKZA 2QFRA 4H2FA 1OIEA 3DW8C 3H69A 3JYFA 4UT2A 1QHWA 3TGHA 4O24A 1IT6A 4V0XA 1WAO1 3QFKA 2HY1A 2O8GA 2BQ8X 1HPUA 2XMOA 1USHA
chains in the Genus database with same CATH superfamily
5EQVA 3T1IA 3K7VC 3ZTVA 3QG5C 1OI8A 3C5WC 1KBPA 3QFMA 4UWQA 4IL1A 2A22A 1MF8A 1M63A 3GVEA 1QFCA 3IB8A 3DSCA 4KBPA 2WDEA 4O4KA 3RL4A 4MOYA 2Z72A 2WDDA 1S8EA 4UT3A 4J6OA 4MP0A 3AV0A 3IVEA 5JJTA 2JOGA 2QFPA 3H63A 3ZU0A 5C1VA 1OIDA 1JK7A 1FJMA 4ORBA 1AUIA 3N5UA 3RL3A 2Q8UA 4O5GA 4V0WA 1Z2WA 3D03A 3IB7A 3ICFA 4H1SA 3K7WC 1T70A 4H2BA 1W24A 3E7AA 1SU1A 2BDXA 4ORCA 2YVTA 1T71A 1UTEA 4H2GA 4ORAA 3H62B 1HO5A 4G9JA 5JPEA 1U32A 4H2IA 5IOHA 3E0JA 5DNYA 4UT3B 4WWLA 3THOB 5INBA 4HD0A 1S3LA 2NYLC 2GJUA 4DSYA 4B2OA 3E7BA 2WDFA 2NXFA 1UF3A 2P6BA 4FBWA 4Q7FA 3CK2A 4H1YP 3KBPA 4FBQA 2QJCA 4I5NC 3H68A 3QFNA 3H61A 2WDCA 2AHDA 3H64A 4LTYA 1S3NA 2USHA 4JA9A 3RQZA 4TUIA 2Z1AA 3THNA 1S70A 1Z2XA 1V73A 2IE4C 2ZO9B 4LACC 4TUGA 4DT2A 4FBKA 5F3WA 5GTUA 2NPPC 3HVQA 4MOVA 1XM7A 4DHLA 1NNWA 3PSNA 1II7A 4IYPC 1S3MA 2DXLA 2CV9A 2Z06A 3V4YA 2YEQA 2DFJA 2O8AA 1TCOA 2HYPA 3AUZA 4M0VA 4F0ZA 4ZX2A 4ZVZA 2KKNA 2R17A 4O43A 3PSOA 4OR9A 5HPEA 5JPFA 1WARA 4V0VA 3RL5A 2HYOA 3IVDA 2NYMC 3DSDA 1XZWA 2BCDA 3EGGA 4LU9A 4FCXA 3H60A 1HP1A 4NZVA 1S95A 3QFOA 2IE3C 4I5LC 3H67A 1G5BA 2ZBMA 4YKEA 5J28A 3C9FA 3P71C 5B8IA 4JA7A 2IAEC 3EGHA 3FGAC 3H66A 3LL8A 4XPNA 4KKZA 2QFRA 3FLOA 4H2FA 1OIEA 3DW8C 3H69A 2DXNA 3JYFA 4UT2A 1QHWA 3TGHA 4O24A 1IT6A 4V0XA 1WAO1 3QFKA 2HY1A 2O8GA 2ZOAA 2BQ8X 1HPUA 2XMOA 1USHA
chains in the Genus database with same CATH topology
5EQVA 3T1IA 3K7VC 3ZTVA 3QG5C 1OI8A 3C5WC 1KBPA 3QFMA 4UWQA 4IL1A 2A22A 1MF8A 1M63A 3GVEA 1QFCA 3IB8A 3DSCA 4KBPA 2WDEA 4O4KA 3RL4A 4MOYA 2Z72A 2WDDA 1S8EA 4UT3A 4J6OA 4MP0A 3AV0A 3IVEA 5JJTA 2JOGA 2QFPA 3H63A 3ZU0A 5C1VA 1OIDA 1JK7A 1FJMA 4ORBA 1AUIA 3N5UA 3RL3A 2Q8UA 4O5GA 4V0WA 1Z2WA 3D03A 3IB7A 3ICFA 4H1SA 3K7WC 1T70A 4H2BA 1W24A 3E7AA 1SU1A 2BDXA 4ORCA 2YVTA 1T71A 1UTEA 4H2GA 4ORAA 3H62B 1HO5A 4G9JA 5JPEA 1U32A 4H2IA 5IOHA 3E0JA 5DNYA 4UT3B 4WWLA 3THOB 5INBA 4HD0A 1S3LA 2NYLC 2GJUA 4DSYA 4B2OA 3E7BA 2WDFA 2NXFA 1UF3A 2P6BA 4FBWA 4Q7FA 3CK2A 4H1YP 3KBPA 4FBQA 2QJCA 4I5NC 3H68A 3QFNA 3H61A 2WDCA 2AHDA 3H64A 4LTYA 1S3NA 2USHA 4JA9A 3RQZA 4TUIA 2Z1AA 3THNA 1S70A 1Z2XA 1V73A 2IE4C 2ZO9B 4LACC 4TUGA 4DT2A 4FBKA 5F3WA 5GTUA 2NPPC 3HVQA 4MOVA 1XM7A 4DHLA 1NNWA 3PSNA 1II7A 4IYPC 1S3MA 2DXLA 2CV9A 2Z06A 3V4YA 2YEQA 2DFJA 2O8AA 1TCOA 2HYPA 3AUZA 4M0VA 4F0ZA 4ZX2A 4ZVZA 2KKNA 2R17A 4O43A 3PSOA 4OR9A 5HPEA 5JPFA 1WARA 4V0VA 3RL5A 2HYOA 3IVDA 2NYMC 3DSDA 1XZWA 2BCDA 3EGGA 4LU9A 4FCXA 3H60A 1HP1A 4NZVA 1S95A 3QFOA 2IE3C 4I5LC 3H67A 1G5BA 2ZBMA 4YKEA 5J28A 3C9FA 3P71C 5B8IA 4JA7A 2IAEC 3EGHA 3FGAC 3H66A 3LL8A 4XPNA 4KKZA 2QFRA 3FLOA 4H2FA 1OIEA 3DW8C 3H69A 2DXNA 3JYFA 4UT2A 1QHWA 3TGHA 4O24A 1IT6A 4V0XA 1WAO1 3QFKA 2HY1A 2O8GA 2ZOAA 2BQ8X 1HPUA 2XMOA 1USHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EQV A;  3T1I A;  3K7V C;  3ZTV A;  3QG5 C;  1OI8 A;  3C5W C;  1KBP A;  3QFM A;  4UWQ A;  4IL1 A;  2A22 A;  1MF8 A;  1M63 A;  3GVE A;  1QFC A;  3IB8 A;  3DSC A;  4KBP A;  2WDE A;  4O4K A;  3RL4 A;  4MOY A;  2Z72 A;  2WDD A;  1S8E A;  4UT3 A;  4J6O A;  4MP0 A;  3AV0 A;  3IVE A;  5JJT A;  2JOG A;  2QFP A;  3H63 A;  3ZU0 A;  5C1V A;  1OID A;  1JK7 A;  1FJM A;  4ORB A;  1AUI A;  3N5U A;  3RL3 A;  2Q8U A;  4O5G A;  4V0W A;  1Z2W A;  4H1S A;  3IB7 A;  3ICF A;  3K7W C;  1T70 A;  4H2B A;  1W24 A;  3E7A A;  1SU1 A;  2BDX A;  4ORC A;  2YVT A;  1T71 A;  1UTE A;  4H2G A;  4ORA A;  3H62 B;  1HO5 A;  4G9J A;  5JPE A;  1U32 A;  4H2I A;  5IOH A;  5DNY A;  4UT3 B;  4WWL A;  3THO B;  5INB A;  4HD0 A;  1S3L A;  2NYL C;  2GJU A;  4DSY A;  4B2O A;  3E7B A;  2WDF A;  2NXF A;  1UF3 A;  2P6B A;  4FBW A;  4Q7F A;  3CK2 A;  4H1Y P;  3KBP A;  4FBQ A;  2QJC A;  4I5N C;  3H68 A;  3QFN A;  3H61 A;  2WDC A;  2AHD A;  3H64 A;  4LTY A;  1S3N A;  2USH A;  4JA9 A;  3RQZ A;  4TUI A;  2Z1A A;  3THN A;  1S70 A;  1Z2X A;  1V73 A;  2IE4 C;  4LAC C;  4TUG A;  4DT2 A;  4FBK A;  5F3W A;  5GTU A;  2NPP C;  3HVQ A;  4MOV A;  1XM7 A;  4DHL A;  1NNW A;  3PSN A;  1II7 A;  4IYP C;  1S3M A;  2Z06 A;  2CV9 A;  3V4Y A;  2DFJ A;  2O8A A;  1TCO A;  2HYP A;  3AUZ A;  4M0V A;  4F0Z A;  4ZX2 A;  4ZVZ A;  2KKN A;  2R17 A;  4O43 A;  3PSO A;  4OR9 A;  5HPE A;  5JPF A;  1WAR A;  4V0V A;  3RL5 A;  2HYO A;  3IVD A;  2NYM C;  3DSD A;  1XZW A;  2BCD A;  3EGG A;  4LU9 A;  4FCX A;  3H60 A;  1HP1 A;  4NZV A;  1S95 A;  3QFO A;  2IE3 C;  4I5L C;  3H67 A;  1G5B A;  2ZBM A;  4YKE A;  5J28 A;  3C9F A;  3P71 C;  5B8I A;  4JA7 A;  2IAE C;  3EGH A;  3FGA C;  3H66 A;  3LL8 A;  4XPN A;  4KKZ A;  2QFR A;  4H2F A;  1OIE A;  3DW8 C;  3H69 A;  3JYF A;  4UT2 A;  1QHW A;  3TGH A;  4O24 A;  1IT6 A;  4V0X A;  1WAO 1;  3QFK A;  2HY1 A;  2O8G A;  2BQ8 X;  1HPU A;  2XMO A;  1USH A; 
#chains in the Genus database with same CATH topology
 5EQV A;  3T1I A;  3K7V C;  3ZTV A;  3QG5 C;  1OI8 A;  3C5W C;  1KBP A;  3QFM A;  4UWQ A;  4IL1 A;  2A22 A;  1MF8 A;  1M63 A;  3GVE A;  1QFC A;  3IB8 A;  3DSC A;  4KBP A;  2WDE A;  4O4K A;  3RL4 A;  4MOY A;  2Z72 A;  2WDD A;  1S8E A;  4UT3 A;  4J6O A;  4MP0 A;  3AV0 A;  3IVE A;  5JJT A;  2JOG A;  2QFP A;  3H63 A;  3ZU0 A;  5C1V A;  1OID A;  1JK7 A;  1FJM A;  4ORB A;  1AUI A;  3N5U A;  3RL3 A;  2Q8U A;  4O5G A;  4V0W A;  1Z2W A;  3D03 A;  3IB7 A;  3ICF A;  4H1S A;  3K7W C;  1T70 A;  4H2B A;  1W24 A;  3E7A A;  1SU1 A;  2BDX A;  4ORC A;  2YVT A;  1T71 A;  1UTE A;  4H2G A;  4ORA A;  3H62 B;  1HO5 A;  4G9J A;  5JPE A;  1U32 A;  4H2I A;  5IOH A;  3E0J A;  5DNY A;  4UT3 B;  4WWL A;  3THO B;  5INB A;  4HD0 A;  1S3L A;  2NYL C;  2GJU A;  4DSY A;  4B2O A;  3E7B A;  2WDF A;  2NXF A;  1UF3 A;  2P6B A;  4FBW A;  4Q7F A;  3CK2 A;  4H1Y P;  3KBP A;  4FBQ A;  2QJC A;  4I5N C;  3H68 A;  3QFN A;  3H61 A;  2WDC A;  2AHD A;  3H64 A;  4LTY A;  1S3N A;  2USH A;  4JA9 A;  3RQZ A;  4TUI A;  2Z1A A;  3THN A;  1S70 A;  1Z2X A;  1V73 A;  2IE4 C;  2ZO9 B;  4LAC C;  4TUG A;  4DT2 A;  4FBK A;  5F3W A;  5GTU A;  2NPP C;  3HVQ A;  4MOV A;  1XM7 A;  4DHL A;  1NNW A;  3PSN A;  1II7 A;  4IYP C;  1S3M A;  2DXL A;  2CV9 A;  2Z06 A;  3V4Y A;  2YEQ A;  2DFJ A;  2O8A A;  1TCO A;  2HYP A;  3AUZ A;  4M0V A;  4F0Z A;  4ZX2 A;  4ZVZ A;  2KKN A;  2R17 A;  4O43 A;  3PSO A;  4OR9 A;  5HPE A;  5JPF A;  1WAR A;  4V0V A;  3RL5 A;  2HYO A;  3IVD A;  2NYM C;  3DSD A;  1XZW A;  2BCD A;  3EGG A;  4LU9 A;  4FCX A;  3H60 A;  1HP1 A;  4NZV A;  1S95 A;  3QFO A;  2IE3 C;  4I5L C;  3H67 A;  1G5B A;  2ZBM A;  4YKE A;  5J28 A;  3C9F A;  3P71 C;  5B8I A;  4JA7 A;  2IAE C;  3EGH A;  3FGA C;  3H66 A;  3LL8 A;  4XPN A;  4KKZ A;  2QFR A;  3FLO A;  4H2F A;  1OIE A;  3DW8 C;  3H69 A;  2DXN A;  3JYF A;  4UT2 A;  1QHW A;  3TGH A;  4O24 A;  1IT6 A;  4V0X A;  1WAO 1;  3QFK A;  2HY1 A;  2O8G A;  2ZOA A;  2BQ8 X;  1HPU A;  2XMO A;  1USH A; 
#chains in the Genus database with same CATH homology
 5EQV A;  3T1I A;  3K7V C;  3ZTV A;  3QG5 C;  1OI8 A;  3C5W C;  1KBP A;  3QFM A;  4UWQ A;  4IL1 A;  2A22 A;  1MF8 A;  1M63 A;  3GVE A;  1QFC A;  3IB8 A;  3DSC A;  4KBP A;  2WDE A;  4O4K A;  3RL4 A;  4MOY A;  2Z72 A;  2WDD A;  1S8E A;  4UT3 A;  4J6O A;  4MP0 A;  3AV0 A;  3IVE A;  5JJT A;  2JOG A;  2QFP A;  3H63 A;  3ZU0 A;  5C1V A;  1OID A;  1JK7 A;  1FJM A;  4ORB A;  1AUI A;  3N5U A;  3RL3 A;  2Q8U A;  4O5G A;  4V0W A;  1Z2W A;  3D03 A;  3IB7 A;  3ICF A;  4H1S A;  3K7W C;  1T70 A;  4H2B A;  1W24 A;  3E7A A;  1SU1 A;  2BDX A;  4ORC A;  2YVT A;  1T71 A;  1UTE A;  4H2G A;  4ORA A;  3H62 B;  1HO5 A;  4G9J A;  5JPE A;  1U32 A;  4H2I A;  5IOH A;  3E0J A;  5DNY A;  4UT3 B;  4WWL A;  3THO B;  5INB A;  4HD0 A;  1S3L A;  2NYL C;  2GJU A;  4DSY A;  4B2O A;  3E7B A;  2WDF A;  2NXF A;  1UF3 A;  2P6B A;  4FBW A;  4Q7F A;  3CK2 A;  4H1Y P;  3KBP A;  4FBQ A;  2QJC A;  4I5N C;  3H68 A;  3QFN A;  3H61 A;  2WDC A;  2AHD A;  3H64 A;  4LTY A;  1S3N A;  2USH A;  4JA9 A;  3RQZ A;  4TUI A;  2Z1A A;  3THN A;  1S70 A;  1Z2X A;  1V73 A;  2IE4 C;  2ZO9 B;  4LAC C;  4TUG A;  4DT2 A;  4FBK A;  5F3W A;  5GTU A;  2NPP C;  3HVQ A;  4MOV A;  1XM7 A;  4DHL A;  1NNW A;  3PSN A;  1II7 A;  4IYP C;  1S3M A;  2DXL A;  2CV9 A;  2Z06 A;  3V4Y A;  2YEQ A;  2DFJ A;  2O8A A;  1TCO A;  2HYP A;  3AUZ A;  4M0V A;  4F0Z A;  4ZX2 A;  4ZVZ A;  2KKN A;  2R17 A;  4O43 A;  3PSO A;  4OR9 A;  5HPE A;  5JPF A;  1WAR A;  4V0V A;  3RL5 A;  2HYO A;  3IVD A;  2NYM C;  3DSD A;  1XZW A;  2BCD A;  3EGG A;  4LU9 A;  4FCX A;  3H60 A;  1HP1 A;  4NZV A;  1S95 A;  3QFO A;  2IE3 C;  4I5L C;  3H67 A;  1G5B A;  2ZBM A;  4YKE A;  5J28 A;  3C9F A;  3P71 C;  5B8I A;  4JA7 A;  2IAE C;  3EGH A;  3FGA C;  3H66 A;  3LL8 A;  4XPN A;  4KKZ A;  2QFR A;  3FLO A;  4H2F A;  1OIE A;  3DW8 C;  3H69 A;  2DXN A;  3JYF A;  4UT2 A;  1QHW A;  3TGH A;  4O24 A;  1IT6 A;  4V0X A;  1WAO 1;  3QFK A;  2HY1 A;  2O8G A;  2ZOA A;  2BQ8 X;  1HPU A;  2XMO A;  1USH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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