2R7ZL

Cisplatin lesion containing rna polymerase ii elongation complex
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of transcriptional stalling at cisplatin-damaged DNA.
pubmed doi rcsb
molecule tags Transcription/dna-rna hybrid
molecule keywords 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3'
total genus 1
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2007-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 2r7zL00
3HOVL 2R92L 3S1NL 1Y1WL 3S15L 4A3BL 2NVXL 1TWGL 5C3EL 3S2HL 1I6HL 4C3HL 5FJ8L 3RZDL 5M5YL 4A3IL 2VUML 4Y52L 3GTML 4BXXL 1K83L 5M5WL 4BY7L 3GTLL 4A3FL 3HOUL 2PMZP 3CQZL 3HOYL 5M3FL 3HKZP 4BBSL 4A3CL 4C3IL 5M5XL 2Y0SP 4A3EL 2E2HL 3I4NL 5C44L 4C2M1 4AYBP 5IYDL 5FLML 4A93L 3HOWL 3GTGL 2YU9L 3GTJL 1Y1VL 3S16L 2JA5L 3RZOL 5IYCL 2JA7L 1I3QL 2R7ZL 5IP7L 3S14L 4A3LL 3S2DL 3GTOL 4BY1L 2WB1P 3HOXL 3GTQL 4A3GL 1SFOL 4A3DL 3PO3L 4QIWP 3PO2L 2WAQP 1I50L 2E2IL 2B63L 3S1QL 3FKIL 3M4OL 3K7AL 2R93L 3I4ML 2JA8L 3GTKL 1TWAL 5IYBL 2NVYL 2JA6L 2NVTL 4A3KL 3H3VM 1TWCL 3H0GL 5M3ML 3GTPL 4X6AL 4C3JL 3S17L 4A3ML 3HOZL 1TWHL 4Y7NL 4A3JL 3S1RL 2NVQL 3S1ML 2E2JL 3M3YL 5C4XL 1WCML 5C4JL 5IP9L 1R9TL 1TWFL 4BBRL
chains in the Genus database with same CATH superfamily
3LPEB 2R92L 1BFYA 3LNLA 2XJVA 3S15L 2CKAA 2NVXL 3S2HL 1B2JA 1S30A 2V0EA 5DM61 2VL6A 1B2OA 1ZRPA 2PPTA 4BXXL 3QQCE 1QYBA 4AHYA 2A6HD 3GTLL 4A3FL 1OWCA 1Z92B 1BQ8A 2DSXA 5M5XL 3B08B 2JI2A 4A3EL 3JR7A 5C44L 2V3BB 3H9CA 2KN9A 4TVMA 5FLML 4A93L 5MF6A 3PZAA 2YU9L 1Y1VL 6RXNA 2JA5L 1I3QL 3B0AB 3KYUA 2R7ZL 3HAXC 1VCXA 4LHLA 2ERJA 4V196 3P2AA 4BY1L 1F4LA 1YK5A 1SFOL 3PKIA 2A6ED 3KYYA 4AR4A 1VZHA 2Z3RB 8RXNA 3K7AL 4UY81 1NXGA 1PZXA 5IYBL 2JA6L 3RZ6A 4A3KL 5M3ML 3GTPL 3HJYB 4C3JL 3MSUA 1LKPA 2GMGA 1YUXA 3HOZL 1TWHL 1R0GA 5RXNA 3S1RL 3P8BA 2E2JL 3S1ML 2XJPA 3M3YL 2M4VA 2HVYC 1RYQA 2XJQA 5C3EL 3PIP1 1RWDA 4C3HL 1WJVA 1YV1A 3WWNB 5GAHc 5AI3A 5GADc 1K83L 2PMZP 3J7Z1 2XJSA 4AR5A 5K2ME 2PVXA 3MPSA 4YWLA 4A3CL 2KKDA 3A44A 1S24A 4AHWA 1ODHA 1RB9A 4C2M1 2M6PA 1IW7D 2L0ZA 1R0FA 4XGHA 4POFA 3HOWL 3GTGL 1QCVA 3RZOL 4POGA 5JVH1 1T9PA 4JAFA 3S14L 4A3LL 2MS3A 3GTOL 1C09A 2WB1P 3HOXL 5IY0A 2ERSA 3NFPI 3PO2L 2LCQA 1I50L 2WAQP 1IRNA 1R0JA 2M6OA 3LWQB 4K9FA 3FKIL 3M4OL 3MQKB 1LKMA 1CAAA 2XJRA 4ZN3B 3I4ML 2R93L 2EY4E 4JADA 1TWAL 1BQ9A 4JAEA 2PVEA 3PWFA 1NXEA 3S17L 2V0FA 5DM71 4A3JL 3LWVB 2CR8A 5C4XL 2AUSB 3KYXA 1IU5A 2XJUA 1S2ZA 3LWOB 3HOVL 4XXBB 3S1NL 1Y1WL 1QQTA 4A3BL 1TWGL 2AYJA 1I6HL 2A68D 5FJ8L 4A3IL 3H99A 4E6YA 2BE5D 1B13A 2Z3QB 4AR3A 5MFZA 2JI1A 2AQCA 4AI2A 5M5WL 1IROA 3HOUL 4GS7D 3HOYL 3KYVA 3HKZP 3PKJA 1OWBA 4BBSL 7RXNA 4C3IL 2QL0A 2Y0SP 3I4NL 4AI3A 3IU3I 2J9UB 2APOB 4AYBP 5IYDL 3SS2A 1YK4A 3J7Y1 4YWMA 1SMUA 2JA7L 4AI1A 1E8JA 1DVBA 1BRFA 3S2DL 1RDVA 4B8CD 1RDGA 3GTQL 2H12A 1VZIA 4A3DL 3LWRB 2C6BA 4QIWP 4G6BA 2B63L 1B71A 5H1Sc 1FHMA 2CKCA 1P7PA 2O5JD 3PIO1 1TWCL 3PL5A 3H0GL 2A69D 4X6AL 4TPUA 4A3ML 5MLC3 3HJWB 1PFUA 2B5ID 4ZN1B 1PFVA 1LKOA 2NVQL 1R0IA 4AHZA 1WCML 5MFPA 5C4JL 2PSMC 3FDJA 5IP9L 3QVDA 1RYTA 5MGNA 2ZIXA 3LWPB 4RXNA 1PFWA 3RZDL 1PFYA 5EIOC 5M5YL 3KYWA 2VUML 1T9OA 1YUZA 1BE7A 1R0HA 4Y52L 3GTML 5GAEc 2M4YA 1JYBA 2RFKB 4BY7L 1FHHA 3CQZL 4LHNA 5M3FL 1IU6A 5AN9H 2C6AA 5GAGc 2RDVA 2K2DA 3WWLA 2E2HL 1T9QA 1DX8A 1VZGA 4AR6A 5JVG1 1SMWA 3GTJL 3S16L 5IYCL 2JI3A 5IP7L 3K35A 1SMMA 1NNQA 5AI2A 4A3GL 2PYAA 3RYGA 3PO3L 3ZG6A 4WFN1 3VPBE 2NYDA 2E2IL 3S1QL 1CADA 3H9BA 2JA8L 2HR5A 3GTKL 4ME3A 2NVYL 2NVTL 4JAGA 1H7VA 3H3VM 3RZTA 4AHXA 1LTLA 4U671 4Y7NL 5EINC 2XJTA 4AI0A 1R9TL 1TWFL 4BBRL 3H97A
chains in the Genus database with same CATH topology
3HOVL 2R92L 3S1NL 1Y1WL 3S15L 4A3BL 2NVXL 1TWGL 5C3EL 3S2HL 1I6HL 4C3HL 5FJ8L 3RZDL 5M5YL 4A3IL 2VUML 4Y52L 3GTML 4BXXL 1K83L 5M5WL 4BY7L 3GTLL 4A3FL 3HOUL 2PMZP 3CQZL 3HOYL 5M3FL 3HKZP 4BBSL 4A3CL 4C3IL 5M5XL 2Y0SP 4A3EL 2E2HL 3I4NL 5C44L 4C2M1 4AYBP 5IYDL 5FLML 4A93L 3HOWL 3GTGL 2YU9L 3GTJL 1Y1VL 3S16L 2JA5L 3RZOL 5IYCL 2JA7L 1I3QL 2R7ZL 5IP7L 3S14L 4A3LL 3S2DL 3GTOL 4BY1L 2WB1P 3HOXL 3GTQL 4A3GL 1SFOL 4A3DL 3PO3L 4QIWP 3PO2L 2WAQP 1I50L 2E2IL 2B63L 3S1QL 3FKIL 3M4OL 3K7AL 2R93L 3I4ML 2JA8L 3GTKL 1TWAL 5IYBL 2NVYL 2JA6L 2NVTL 4A3KL 3H3VM 1TWCL 3H0GL 5M3ML 3GTPL 4X6AL 4C3JL 3S17L 4A3ML 3HOZL 1TWHL 4Y7NL 4A3JL 3S1RL 2NVQL 3S1ML 2E2JL 3M3YL 5C4XL 1WCML 5C4JL 5IP9L 1R9TL 1TWFL 4BBRL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HOV L;  2R92 L;  3S1N L;  1Y1W L;  3S15 L;  4A3B L;  2NVX L;  1TWG L;  5C3E L;  3S2H L;  1I6H L;  4C3H L;  5FJ8 L;  3RZD L;  5M5Y L;  4A3I L;  2VUM L;  4Y52 L;  3GTM L;  4BXX L;  1K83 L;  5M5W L;  4BY7 L;  3GTL L;  4A3F L;  3HOU L;  2PMZ P;  3CQZ L;  3HOY L;  5M3F L;  3HKZ P;  4BBS L;  4A3C L;  4C3I L;  5M5X L;  2Y0S P;  4A3E L;  2E2H L;  3I4N L;  5C44 L;  4C2M 1;  4AYB P;  5IYD L;  5FLM L;  4A93 L;  3HOW L;  3GTG L;  2YU9 L;  3GTJ L;  1Y1V L;  3S16 L;  2JA5 L;  3RZO L;  5IYC L;  2JA7 L;  1I3Q L;  2R7Z L;  5IP7 L;  3S14 L;  4A3L L;  3S2D L;  3GTO L;  4BY1 L;  2WB1 P;  3HOX L;  3GTQ L;  4A3G L;  1SFO L;  4A3D L;  3PO3 L;  4QIW P;  3PO2 L;  2WAQ P;  1I50 L;  2E2I L;  2B63 L;  3S1Q L;  3FKI L;  3M4O L;  3K7A L;  2R93 L;  3I4M L;  2JA8 L;  3GTK L;  1TWA L;  5IYB L;  2NVY L;  2JA6 L;  2NVT L;  4A3K L;  3H3V M;  1TWC L;  3H0G L;  5M3M L;  3GTP L;  4X6A L;  4C3J L;  3S17 L;  4A3M L;  3HOZ L;  1TWH L;  4Y7N L;  4A3J L;  3S1R L;  2NVQ L;  3S1M L;  2E2J L;  3M3Y L;  5C4X L;  1WCM L;  5C4J L;  5IP9 L;  1R9T L;  1TWF L;  4BBR L; 
#chains in the Genus database with same CATH topology
 3LPE B;  2R92 L;  1BFY A;  3LNL A;  2XJV A;  3S15 L;  2CKA A;  2NVX L;  3S2H L;  1B2J A;  1S30 A;  2V0E A;  5DM6 1;  2VL6 A;  1B2O A;  1ZRP A;  2PPT A;  4BXX L;  3QQC E;  1QYB A;  4AHY A;  2A6H D;  3GTL L;  4A3F L;  1OWC A;  1Z92 B;  1BQ8 A;  2DSX A;  5M5X L;  3B08 B;  2JI2 A;  4A3E L;  3JR7 A;  5C44 L;  2V3B B;  3H9C A;  2KN9 A;  4TVM A;  5FLM L;  4A93 L;  5MF6 A;  3PZA A;  2YU9 L;  1Y1V L;  6RXN A;  2JA5 L;  1I3Q L;  3B0A B;  3KYU A;  2R7Z L;  3HAX C;  1VCX A;  4LHL A;  2ERJ A;  4V19 6;  3P2A A;  4BY1 L;  1F4L A;  1YK5 A;  1SFO L;  3PKI A;  2A6E D;  3KYY A;  4AR4 A;  1VZH A;  2Z3R B;  8RXN A;  3K7A L;  4UY8 1;  1NXG A;  1PZX A;  5IYB L;  2JA6 L;  3RZ6 A;  4A3K L;  5M3M L;  3GTP L;  3HJY B;  4C3J L;  3MSU A;  1LKP A;  2GMG A;  1YUX A;  3HOZ L;  1TWH L;  1R0G A;  5RXN A;  3S1R L;  3P8B A;  2E2J L;  3S1M L;  2XJP A;  3M3Y L;  2M4V A;  2HVY C;  1RYQ A;  2XJQ A;  5C3E L;  3PIP 1;  1RWD A;  4C3H L;  1WJV A;  1YV1 A;  3WWN B;  5GAH c;  5AI3 A;  5GAD c;  1K83 L;  2PMZ P;  3J7Z 1;  2XJS A;  4AR5 A;  5K2M E;  2PVX A;  3MPS A;  4YWL A;  4A3C L;  2KKD A;  3A44 A;  1S24 A;  4AHW A;  1ODH A;  1RB9 A;  4C2M 1;  2M6P A;  1IW7 D;  2L0Z A;  1R0F A;  4XGH A;  4POF A;  3HOW L;  3GTG L;  1QCV A;  3RZO L;  4POG A;  5JVH 1;  1T9P A;  4JAF A;  3S14 L;  4A3L L;  2MS3 A;  3GTO L;  1C09 A;  2WB1 P;  3HOX L;  5IY0 A;  2ERS A;  3NFP I;  3PO2 L;  2LCQ A;  1I50 L;  2WAQ P;  1IRN A;  1R0J A;  2M6O A;  3LWQ B;  4K9F A;  3FKI L;  3M4O L;  3MQK B;  1LKM A;  1CAA A;  2XJR A;  4ZN3 B;  3I4M L;  2R93 L;  2EY4 E;  4JAD A;  1TWA L;  1BQ9 A;  4JAE A;  2PVE A;  3PWF A;  1NXE A;  3S17 L;  2V0F A;  5DM7 1;  4A3J L;  3LWV B;  2CR8 A;  5C4X L;  2AUS B;  3KYX A;  1IU5 A;  2XJU A;  1S2Z A;  3LWO B;  3HOV L;  4XXB B;  3S1N L;  1Y1W L;  1QQT A;  4A3B L;  1TWG L;  2AYJ A;  1I6H L;  2A68 D;  5FJ8 L;  4A3I L;  3H99 A;  4E6Y A;  2BE5 D;  1B13 A;  2Z3Q B;  4AR3 A;  5MFZ A;  2JI1 A;  2AQC A;  4AI2 A;  5M5W L;  1IRO A;  3HOU L;  4GS7 D;  3HOY L;  3KYV A;  3HKZ P;  3PKJ A;  1OWB A;  4BBS L;  7RXN A;  4C3I L;  2QL0 A;  2Y0S P;  3I4N L;  4AI3 A;  3IU3 I;  2J9U B;  2APO B;  4AYB P;  5IYD L;  3SS2 A;  1YK4 A;  3J7Y 1;  4YWM A;  1SMU A;  2JA7 L;  4AI1 A;  1E8J A;  1DVB A;  1BRF A;  3S2D L;  1RDV A;  4B8C D;  1RDG A;  3GTQ L;  2H12 A;  1VZI A;  4A3D L;  3LWR B;  2C6B A;  4QIW P;  4G6B A;  2B63 L;  1B71 A;  5H1S c;  1FHM A;  2CKC A;  1P7P A;  2O5J D;  3PIO 1;  1TWC L;  3PL5 A;  3H0G L;  2A69 D;  4X6A L;  4TPU A;  4A3M L;  5MLC 3;  3HJW B;  1PFU A;  2B5I D;  4ZN1 B;  1PFV A;  1LKO A;  2NVQ L;  1R0I A;  4AHZ A;  1WCM L;  5MFP A;  5C4J L;  2PSM C;  3FDJ A;  5IP9 L;  3QVD A;  1RYT A;  5MGN A;  2ZIX A;  3LWP B;  4RXN A;  1PFW A;  3RZD L;  1PFY A;  5EIO C;  5M5Y L;  3KYW A;  2VUM L;  1T9O A;  1YUZ A;  1BE7 A;  1R0H A;  4Y52 L;  3GTM L;  5GAE c;  2M4Y A;  1JYB A;  2RFK B;  4BY7 L;  1FHH A;  3CQZ L;  4LHN A;  5M3F L;  1IU6 A;  5AN9 H;  2C6A A;  5GAG c;  2RDV A;  2K2D A;  3WWL A;  2E2H L;  1T9Q A;  1DX8 A;  1VZG A;  4AR6 A;  5JVG 1;  1SMW A;  3GTJ L;  3S16 L;  5IYC L;  2JI3 A;  5IP7 L;  3K35 A;  1SMM A;  1NNQ A;  5AI2 A;  4A3G L;  2PYA A;  3RYG A;  3PO3 L;  3ZG6 A;  4WFN 1;  3VPB E;  2NYD A;  2E2I L;  3S1Q L;  1CAD A;  3H9B A;  2JA8 L;  2HR5 A;  3GTK L;  4ME3 A;  2NVY L;  2NVT L;  4JAG A;  1H7V A;  3H3V M;  3RZT A;  4AHX A;  1LTL A;  4U67 1;  4Y7N L;  5EIN C;  2XJT A;  4AI0 A;  1R9T L;  1TWF L;  4BBR L;  3H97 A; 
#chains in the Genus database with same CATH homology
 3HOV L;  2R92 L;  3S1N L;  1Y1W L;  3S15 L;  4A3B L;  2NVX L;  1TWG L;  5C3E L;  3S2H L;  1I6H L;  4C3H L;  5FJ8 L;  3RZD L;  5M5Y L;  4A3I L;  2VUM L;  4Y52 L;  3GTM L;  4BXX L;  1K83 L;  5M5W L;  4BY7 L;  3GTL L;  4A3F L;  3HOU L;  2PMZ P;  3CQZ L;  3HOY L;  5M3F L;  3HKZ P;  4BBS L;  4A3C L;  4C3I L;  5M5X L;  2Y0S P;  4A3E L;  2E2H L;  3I4N L;  5C44 L;  4C2M 1;  4AYB P;  5IYD L;  5FLM L;  4A93 L;  3HOW L;  3GTG L;  2YU9 L;  3GTJ L;  1Y1V L;  3S16 L;  2JA5 L;  3RZO L;  5IYC L;  2JA7 L;  1I3Q L;  2R7Z L;  5IP7 L;  3S14 L;  4A3L L;  3S2D L;  3GTO L;  4BY1 L;  2WB1 P;  3HOX L;  3GTQ L;  4A3G L;  1SFO L;  4A3D L;  3PO3 L;  4QIW P;  3PO2 L;  2WAQ P;  1I50 L;  2E2I L;  2B63 L;  3S1Q L;  3FKI L;  3M4O L;  3K7A L;  2R93 L;  3I4M L;  2JA8 L;  3GTK L;  1TWA L;  5IYB L;  2NVY L;  2JA6 L;  2NVT L;  4A3K L;  3H3V M;  1TWC L;  3H0G L;  5M3M L;  3GTP L;  4X6A L;  4C3J L;  3S17 L;  4A3M L;  3HOZ L;  1TWH L;  4Y7N L;  4A3J L;  3S1R L;  2NVQ L;  3S1M L;  2E2J L;  3M3Y L;  5C4X L;  1WCM L;  5C4J L;  5IP9 L;  1R9T L;  1TWF L;  4BBR L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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