3C5WC

Complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
304
structure length
294
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPTPDYFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
pubmed doi rcsb
molecule keywords PP2A A subunit
molecule tags Hydrolase
source organism Homo sapiens
total genus 107
structure length 294
sequence length 304
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3c5wC00
2GJUA 4YKEA 3LL8A 4IL1A 3QFMA 4JA9A 1OI8A 2HYOA 1T71A 2KKNA 3QFKA 1MF8A 5J28A 4KKZA 2P6BA 5HPEA 5GTUA 3DW8C 1KBPA 3GVEA 3THOB 4V0VA 1NNWA 5EQVA 1Z2WA 3KBPA 4O5GA 4OR9A 3C9FA 1OIEA 3P71C 2BCDA 3RL4A 4FBKA 3DSDA 2WDEA 3JYFA 1T70A 4ZVZA 1TCOA 5DNYA 1Z2XA 1HPUA 4WWLA 2WDCA 3TGHA 3PSOA 4IYPC 4H2GA 4FBQA 3QFOA 2O8GA 3IB7A 1UTEA 3K7VC 4H2BA 4KBPA 1S70A 4XPNA 1USHA 3THNA 4F0ZA 1IT6A 3E7BA 4UWQA 4MP0A 3ZU0A 3FGAC 1U32A 2ZBMA 4ZX2A 5C1VA 4M0VA 2HYPA 4NZVA 1QHWA 3H61A 3AUZA 1UF3A 1JK7A 1S8EA 3H62B 2YVTA 4O4KA 2NYMC 2IE4C 4TUIA 1II7A 2R17A 1FJMA 5IOHA 2HY1A 1HP1A 1S3MA 2Z06A 3CK2A 2QFPA 4O43A 2A22A 1W24A 3K7WC 3V4YA 1WARA 3EGHA 2BQ8X 4Q7FA 4UT3B 5F3WA 1M63A 3T1IA 4LACC 5INBA 5B8IA 1XZWA 2DFJA 2NPPC 2JOGA 2Z72A 4UT2A 4MOVA 2NYLC 3RL3A 3IB8A 2NXFA 4H1SA 3IVEA 4LU9A 3ZTVA 4G9JA 4B2OA 5JJTA 1S3LA 4FCXA 1OIDA 4ORCA 3RQZA 4I5NC 2O8AA 3H60A 4UT3A 4ORAA 4H2IA 4MOYA 2IAEC 4H2FA 3AV0A 3QG5C 3QFNA 5JPFA 4V0WA 2CV9A 1AUIA 3H64A 2AHDA 4JA7A 2WDFA 1QFCA 4DSYA 4HD0A 3H66A 2BDXA 2Q8UA 3RL5A 1HO5A 4ORBA 3PSNA 4V0XA 1S3NA 1XM7A 4DHLA 1S95A 2QFRA 1V73A 2IE3C 4DT2A 4O24A 3H63A 4I5LC 1WAO1 2QJCA 3E7AA 3HVQA 3ICFA 4LTYA 4TUGA 3DSCA 3H68A 3H69A 2WDDA 3C5WC 3N5UA 5JPEA 1SU1A 4J6OA 3EGGA 1G5BA 2USHA 2XMOA 3H67A 4H1YP 3IVDA 4FBWA 2Z1AA
chains in the Genus database with same CATH superfamily
2GJUA 4YKEA 3LL8A 4IL1A 3QFMA 4JA9A 1OI8A 2HYOA 1T71A 2KKNA 3QFKA 1MF8A 5J28A 4KKZA 2YEQA 2P6BA 5HPEA 5GTUA 3DW8C 1KBPA 3GVEA 3THOB 4V0VA 3E0JA 1NNWA 5EQVA 1Z2WA 3KBPA 4O5GA 4OR9A 3C9FA 1OIEA 3P71C 2BCDA 3RL4A 4FBKA 3DSDA 2ZO9B 2WDEA 3JYFA 1T70A 4ZVZA 1TCOA 5DNYA 1Z2XA 1HPUA 4WWLA 2WDCA 3TGHA 3PSOA 4IYPC 4H2GA 4FBQA 3QFOA 2O8GA 2DXLA 3IB7A 1UTEA 3K7VC 4H2BA 4KBPA 1S70A 4XPNA 1USHA 3THNA 4F0ZA 1IT6A 3E7BA 4UWQA 4MP0A 3ZU0A 3FGAC 1U32A 2ZBMA 4ZX2A 5C1VA 4M0VA 2HYPA 4NZVA 2DXNA 1QHWA 3D03A 3AUZA 1UF3A 3H61A 1JK7A 1S8EA 3H62B 4O4KA 2NYMC 2IE4C 4TUIA 1II7A 2R17A 1FJMA 5IOHA 2HY1A 1HP1A 1S3MA 2Z06A 3CK2A 2QFPA 4O43A 2A22A 1W24A 3K7WC 3V4YA 1WARA 3EGHA 2BQ8X 4Q7FA 4UT3B 5F3WA 1M63A 3T1IA 4LACC 5INBA 5B8IA 1XZWA 2DFJA 2NPPC 2JOGA 2Z72A 4UT2A 4MOVA 2NYLC 3RL3A 3IB8A 2NXFA 4H1SA 3IVEA 4LU9A 3ZTVA 4G9JA 4B2OA 5JJTA 1S3LA 4FCXA 1OIDA 4ORCA 3RQZA 4I5NC 2O8AA 3H60A 4UT3A 4ORAA 4H2IA 4MOYA 2IAEC 4H2FA 3AV0A 3QG5C 3QFNA 5JPFA 4V0WA 2CV9A 1AUIA 3H64A 2AHDA 3FLOA 4JA7A 2WDFA 2Z1AA 1QFCA 4DSYA 4HD0A 3H66A 2BDXA 2Q8UA 3RL5A 1HO5A 4ORBA 3PSNA 4V0XA 1S3NA 1XM7A 4DHLA 1S95A 2QFRA 1V73A 2IE3C 4DT2A 4O24A 3H63A 4I5LC 1WAO1 2QJCA 2ZOAA 3E7AA 3HVQA 3ICFA 4LTYA 4TUGA 3DSCA 3H68A 3H69A 2WDDA 3C5WC 3N5UA 5JPEA 1SU1A 4J6OA 3EGGA 1G5BA 2USHA 2XMOA 3H67A 4H1YP 3IVDA 4FBWA 2YVTA
chains in the Genus database with same CATH topology
2GJUA 4YKEA 3LL8A 4IL1A 3QFMA 4JA9A 1OI8A 2HYOA 1T71A 2KKNA 3QFKA 1MF8A 5J28A 4KKZA 2YEQA 2P6BA 5HPEA 5GTUA 3DW8C 1KBPA 3GVEA 3THOB 4V0VA 3E0JA 1NNWA 5EQVA 1Z2WA 3KBPA 4O5GA 4OR9A 3C9FA 1OIEA 3P71C 2BCDA 3RL4A 4FBKA 3DSDA 2ZO9B 2WDEA 3JYFA 1T70A 4ZVZA 1TCOA 5DNYA 1Z2XA 1HPUA 4WWLA 2WDCA 3TGHA 3PSOA 4IYPC 4H2GA 4FBQA 3QFOA 2O8GA 2DXLA 3IB7A 1UTEA 3K7VC 4H2BA 4KBPA 1S70A 4XPNA 1USHA 3THNA 4F0ZA 1IT6A 3E7BA 4UWQA 4MP0A 3ZU0A 3FGAC 1U32A 2ZBMA 4ZX2A 5C1VA 4M0VA 2HYPA 4NZVA 2DXNA 1QHWA 3D03A 3AUZA 1UF3A 3H61A 1JK7A 1S8EA 3H62B 4O4KA 2NYMC 2IE4C 4TUIA 1II7A 2R17A 1FJMA 5IOHA 2HY1A 1HP1A 1S3MA 2Z06A 3CK2A 2QFPA 4O43A 2A22A 1W24A 3K7WC 3V4YA 1WARA 3EGHA 2BQ8X 4Q7FA 4UT3B 5F3WA 1M63A 3T1IA 4LACC 5INBA 5B8IA 1XZWA 2DFJA 2NPPC 2JOGA 2Z72A 4UT2A 4MOVA 2NYLC 3RL3A 3IB8A 2NXFA 4H1SA 3IVEA 4LU9A 3ZTVA 4G9JA 4B2OA 5JJTA 1S3LA 4FCXA 1OIDA 4ORCA 3RQZA 4I5NC 2O8AA 3H60A 4UT3A 4ORAA 4H2IA 4MOYA 2IAEC 4H2FA 3AV0A 3QG5C 3QFNA 5JPFA 4V0WA 2CV9A 1AUIA 3H64A 2AHDA 3FLOA 4JA7A 2WDFA 2Z1AA 1QFCA 4DSYA 4HD0A 3H66A 2BDXA 2Q8UA 3RL5A 1HO5A 4ORBA 3PSNA 4V0XA 1S3NA 1XM7A 4DHLA 1S95A 2QFRA 1V73A 2IE3C 4DT2A 4O24A 3H63A 4I5LC 1WAO1 2QJCA 2ZOAA 3E7AA 3HVQA 3ICFA 4LTYA 4TUGA 3DSCA 3H68A 3H69A 2WDDA 3C5WC 3N5UA 5JPEA 1SU1A 4J6OA 3EGGA 1G5BA 2USHA 2XMOA 3H67A 4H1YP 3IVDA 4FBWA 2YVTA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GJU A;  4YKE A;  3LL8 A;  4IL1 A;  3QFM A;  4JA9 A;  1OI8 A;  2HYO A;  1T71 A;  2KKN A;  3QFK A;  1MF8 A;  5J28 A;  4KKZ A;  2P6B A;  5HPE A;  5GTU A;  3DW8 C;  1KBP A;  3GVE A;  3THO B;  4V0V A;  1NNW A;  5EQV A;  1Z2W A;  3KBP A;  4O5G A;  4OR9 A;  3C9F A;  1OIE A;  3P71 C;  2BCD A;  3RL4 A;  4FBK A;  3DSD A;  2WDE A;  3JYF A;  1T70 A;  4ZVZ A;  1TCO A;  5DNY A;  1Z2X A;  1HPU A;  4WWL A;  2WDC A;  3TGH A;  3PSO A;  4IYP C;  4H2G A;  4FBQ A;  3QFO A;  2O8G A;  3IB7 A;  1UTE A;  3K7V C;  4H2B A;  4KBP A;  1S70 A;  4XPN A;  1USH A;  3THN A;  4F0Z A;  1IT6 A;  3E7B A;  4UWQ A;  4MP0 A;  3ZU0 A;  3FGA C;  1U32 A;  2ZBM A;  4ZX2 A;  5C1V A;  4M0V A;  2HYP A;  4NZV A;  1QHW A;  3H61 A;  3AUZ A;  1UF3 A;  1JK7 A;  1S8E A;  3H62 B;  2YVT A;  4O4K A;  2NYM C;  2IE4 C;  4TUI A;  1II7 A;  2R17 A;  1FJM A;  5IOH A;  2HY1 A;  1HP1 A;  1S3M A;  2Z06 A;  3CK2 A;  2QFP A;  4O43 A;  2A22 A;  1W24 A;  3K7W C;  3V4Y A;  1WAR A;  3EGH A;  2BQ8 X;  4Q7F A;  4UT3 B;  5F3W A;  1M63 A;  3T1I A;  4LAC C;  5INB A;  5B8I A;  1XZW A;  2DFJ A;  2NPP C;  2JOG A;  2Z72 A;  4UT2 A;  4MOV A;  2NYL C;  3RL3 A;  3IB8 A;  2NXF A;  4H1S A;  3IVE A;  4LU9 A;  3ZTV A;  4G9J A;  4B2O A;  5JJT A;  1S3L A;  4FCX A;  1OID A;  4ORC A;  3RQZ A;  4I5N C;  2O8A A;  3H60 A;  4UT3 A;  4ORA A;  4H2I A;  4MOY A;  2IAE C;  4H2F A;  3AV0 A;  3QG5 C;  3QFN A;  5JPF A;  4V0W A;  2CV9 A;  1AUI A;  3H64 A;  2AHD A;  4JA7 A;  2WDF A;  1QFC A;  4DSY A;  4HD0 A;  3H66 A;  2BDX A;  2Q8U A;  3RL5 A;  1HO5 A;  4ORB A;  3PSN A;  4V0X A;  1S3N A;  1XM7 A;  4DHL A;  1S95 A;  2QFR A;  1V73 A;  2IE3 C;  4DT2 A;  4O24 A;  3H63 A;  4I5L C;  1WAO 1;  2QJC A;  3E7A A;  3HVQ A;  3ICF A;  4LTY A;  4TUG A;  3DSC A;  3H68 A;  3H69 A;  2WDD A;  3C5W C;  3N5U A;  5JPE A;  1SU1 A;  4J6O A;  3EGG A;  1G5B A;  2USH A;  2XMO A;  3H67 A;  4H1Y P;  3IVD A;  4FBW A;  2Z1A A; 
#chains in the Genus database with same CATH topology
 2GJU A;  4YKE A;  3LL8 A;  4IL1 A;  3QFM A;  4JA9 A;  1OI8 A;  2HYO A;  1T71 A;  2KKN A;  3QFK A;  1MF8 A;  5J28 A;  4KKZ A;  2YEQ A;  2P6B A;  5HPE A;  5GTU A;  3DW8 C;  1KBP A;  3GVE A;  3THO B;  4V0V A;  3E0J A;  1NNW A;  5EQV A;  1Z2W A;  3KBP A;  4O5G A;  4OR9 A;  3C9F A;  1OIE A;  3P71 C;  2BCD A;  3RL4 A;  4FBK A;  3DSD A;  2ZO9 B;  2WDE A;  3JYF A;  1T70 A;  4ZVZ A;  1TCO A;  5DNY A;  1Z2X A;  1HPU A;  4WWL A;  2WDC A;  3TGH A;  3PSO A;  4IYP C;  4H2G A;  4FBQ A;  3QFO A;  2O8G A;  2DXL A;  3IB7 A;  1UTE A;  3K7V C;  4H2B A;  4KBP A;  1S70 A;  4XPN A;  1USH A;  3THN A;  4F0Z A;  1IT6 A;  3E7B A;  4UWQ A;  4MP0 A;  3ZU0 A;  3FGA C;  1U32 A;  2ZBM A;  4ZX2 A;  5C1V A;  4M0V A;  2HYP A;  4NZV A;  2DXN A;  1QHW A;  3D03 A;  3AUZ A;  1UF3 A;  3H61 A;  1JK7 A;  1S8E A;  3H62 B;  4O4K A;  2NYM C;  2IE4 C;  4TUI A;  1II7 A;  2R17 A;  1FJM A;  5IOH A;  2HY1 A;  1HP1 A;  1S3M A;  2Z06 A;  3CK2 A;  2QFP A;  4O43 A;  2A22 A;  1W24 A;  3K7W C;  3V4Y A;  1WAR A;  3EGH A;  2BQ8 X;  4Q7F A;  4UT3 B;  5F3W A;  1M63 A;  3T1I A;  4LAC C;  5INB A;  5B8I A;  1XZW A;  2DFJ A;  2NPP C;  2JOG A;  2Z72 A;  4UT2 A;  4MOV A;  2NYL C;  3RL3 A;  3IB8 A;  2NXF A;  4H1S A;  3IVE A;  4LU9 A;  3ZTV A;  4G9J A;  4B2O A;  5JJT A;  1S3L A;  4FCX A;  1OID A;  4ORC A;  3RQZ A;  4I5N C;  2O8A A;  3H60 A;  4UT3 A;  4ORA A;  4H2I A;  4MOY A;  2IAE C;  4H2F A;  3AV0 A;  3QG5 C;  3QFN A;  5JPF A;  4V0W A;  2CV9 A;  1AUI A;  3H64 A;  2AHD A;  3FLO A;  4JA7 A;  2WDF A;  2Z1A A;  1QFC A;  4DSY A;  4HD0 A;  3H66 A;  2BDX A;  2Q8U A;  3RL5 A;  1HO5 A;  4ORB A;  3PSN A;  4V0X A;  1S3N A;  1XM7 A;  4DHL A;  1S95 A;  2QFR A;  1V73 A;  2IE3 C;  4DT2 A;  4O24 A;  3H63 A;  4I5L C;  1WAO 1;  2QJC A;  2ZOA A;  3E7A A;  3HVQ A;  3ICF A;  4LTY A;  4TUG A;  3DSC A;  3H68 A;  3H69 A;  2WDD A;  3C5W C;  3N5U A;  5JPE A;  1SU1 A;  4J6O A;  3EGG A;  1G5B A;  2USH A;  2XMO A;  3H67 A;  4H1Y P;  3IVD A;  4FBW A;  2YVT A; 
#chains in the Genus database with same CATH homology
 2GJU A;  4YKE A;  3LL8 A;  4IL1 A;  3QFM A;  4JA9 A;  1OI8 A;  2HYO A;  1T71 A;  2KKN A;  3QFK A;  1MF8 A;  5J28 A;  4KKZ A;  2YEQ A;  2P6B A;  5HPE A;  5GTU A;  3DW8 C;  1KBP A;  3GVE A;  3THO B;  4V0V A;  3E0J A;  1NNW A;  5EQV A;  1Z2W A;  3KBP A;  4O5G A;  4OR9 A;  3C9F A;  1OIE A;  3P71 C;  2BCD A;  3RL4 A;  4FBK A;  3DSD A;  2ZO9 B;  2WDE A;  3JYF A;  1T70 A;  4ZVZ A;  1TCO A;  5DNY A;  1Z2X A;  1HPU A;  4WWL A;  2WDC A;  3TGH A;  3PSO A;  4IYP C;  4H2G A;  4FBQ A;  3QFO A;  2O8G A;  2DXL A;  3IB7 A;  1UTE A;  3K7V C;  4H2B A;  4KBP A;  1S70 A;  4XPN A;  1USH A;  3THN A;  4F0Z A;  1IT6 A;  3E7B A;  4UWQ A;  4MP0 A;  3ZU0 A;  3FGA C;  1U32 A;  2ZBM A;  4ZX2 A;  5C1V A;  4M0V A;  2HYP A;  4NZV A;  2DXN A;  1QHW A;  3D03 A;  3AUZ A;  1UF3 A;  3H61 A;  1JK7 A;  1S8E A;  3H62 B;  4O4K A;  2NYM C;  2IE4 C;  4TUI A;  1II7 A;  2R17 A;  1FJM A;  5IOH A;  2HY1 A;  1HP1 A;  1S3M A;  2Z06 A;  3CK2 A;  2QFP A;  4O43 A;  2A22 A;  1W24 A;  3K7W C;  3V4Y A;  1WAR A;  3EGH A;  2BQ8 X;  4Q7F A;  4UT3 B;  5F3W A;  1M63 A;  3T1I A;  4LAC C;  5INB A;  5B8I A;  1XZW A;  2DFJ A;  2NPP C;  2JOG A;  2Z72 A;  4UT2 A;  4MOV A;  2NYL C;  3RL3 A;  3IB8 A;  2NXF A;  4H1S A;  3IVE A;  4LU9 A;  3ZTV A;  4G9J A;  4B2O A;  5JJT A;  1S3L A;  4FCX A;  1OID A;  4ORC A;  3RQZ A;  4I5N C;  2O8A A;  3H60 A;  4UT3 A;  4ORA A;  4H2I A;  4MOY A;  2IAE C;  4H2F A;  3AV0 A;  3QG5 C;  3QFN A;  5JPF A;  4V0W A;  2CV9 A;  1AUI A;  3H64 A;  2AHD A;  3FLO A;  4JA7 A;  2WDF A;  2Z1A A;  1QFC A;  4DSY A;  4HD0 A;  3H66 A;  2BDX A;  2Q8U A;  3RL5 A;  1HO5 A;  4ORB A;  3PSN A;  4V0X A;  1S3N A;  1XM7 A;  4DHL A;  1S95 A;  2QFR A;  1V73 A;  2IE3 C;  4DT2 A;  4O24 A;  3H63 A;  4I5L C;  1WAO 1;  2QJC A;  2ZOA A;  3E7A A;  3HVQ A;  3ICF A;  4LTY A;  4TUG A;  3DSC A;  3H68 A;  3H69 A;  2WDD A;  3C5W C;  3N5U A;  5JPE A;  1SU1 A;  4J6O A;  3EGG A;  1G5B A;  2USH A;  2XMO A;  3H67 A;  4H1Y P;  3IVD A;  4FBW A;  2YVT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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