3C5WC

Complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
304
structure length
294
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPTPDYFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
pubmed doi rcsb
molecule keywords PP2A A subunit
total genus 107
structure length 294
sequence length 304
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3c5wC00
1USHA 2ZBMA 3C5WC 2Z72A 1QHWA 4ZVZA 3EGHA 3H64A 1II7A 1OI8A 3C9FA 5IOHA 3AUZA 4FBQA 2GJUA 3IB7A 5INBA 2IAEC 1S70A 1S95A 3QFOA 2KKNA 4UT2A 3ZU0A 5B8IA 1XM7A 3K7VC 3RQZA 4KKZA 2O8AA 2NPPC 2WDEA 2YVTA 1HO5A 5F3WA 1S8EA 1WARA 3H67A 3H63A 4IL1A 4MP0A 4V0WA 2A22A 2XMOA 5EQVA 4ORAA 2Z06A 2DFJA 4H2GA 4NZVA 2USHA 1NNWA 4Q7FA 1UF3A 4DT2A 2QFRA 4O4KA 2WDDA 1OIEA 4KBPA 4YKEA 3HVQA 1M63A 1UTEA 5JPFA 3H68A 3THNA 4O5GA 1W24A 2IE4C 4FBWA 3KBPA 1Z2XA 3PSOA 3PSNA 3H62B 1G5BA 4FBKA 4UT3B 5GTUA 4JA7A 3EGGA 4M0VA 3RL4A 5DNYA 1TCOA 3CK2A 1OIDA 3DW8C 2HYOA 2JOGA 4JA9A 1T70A 4J6OA 3FGAC 4MOYA 3RL3A 1U32A 3JYFA 1Z2WA 3IVDA 4LTYA 4XPNA 5C1VA 1WAO1 2QFPA 2BCDA 4DSYA 4V0XA 4LU9A 4V0VA 2IE3C 4OR9A 3ICFA 2WDFA 4ZX2A 2HY1A 4I5LC 1XZWA 4ORBA 3N5UA 4H2IA 4HD0A 4LACC 4I5NC 3LL8A 4MOVA 3RL5A 3H69A 1T71A 4O24A 3ZTVA 4TUIA 1SU1A 3P71C 4O43A 2QJCA 4FCXA 3IVEA 2WDCA 2BDXA 4DHLA 3GVEA 3AV0A 3H61A 1KBPA 4B2OA 2NYLC 3QFKA 4H1YP 3QFNA 3E7BA 3QFMA 4H2FA 2AHDA 5JJTA 1HPUA 2P6BA 1S3NA 3THOB 2NYMC 3V4YA 4UWQA 1QFCA 4H2BA 3H60A 3QG5C 3E7AA 1V73A 1S3LA 3TGHA 4F0ZA 3T1IA 1S3MA 3IB8A 2BQ8X 4ORCA 4G9JA 1AUIA 5J28A 3DSCA 1MF8A 2NXFA 2Q8UA 5HPEA 1JK7A 2Z1AA 3H66A 3DSDA 1FJMA 2CV9A 1HP1A 2HYPA 3K7WC 4IYPC 4WWLA 4UT3A 2R17A 5JPEA 4H1SA 2O8GA 1IT6A 4TUGA
chains in the Genus database with same CATH superfamily
1USHA 2ZBMA 3C5WC 2Z72A 1QHWA 4ZVZA 3EGHA 3H64A 1II7A 1OI8A 3C9FA 5IOHA 3AUZA 4FBQA 2GJUA 3IB7A 5INBA 2IAEC 1S70A 1S95A 3QFOA 2KKNA 4UT2A 3ZU0A 5B8IA 1XM7A 3K7VC 3D03A 3RQZA 4KKZA 2O8AA 2NPPC 2WDEA 2YVTA 1HO5A 5F3WA 1S8EA 1WARA 3H67A 3H63A 4IL1A 4MP0A 4V0WA 2A22A 2XMOA 5EQVA 4ORAA 2Z06A 2DFJA 4H2GA 4NZVA 2USHA 1NNWA 4Q7FA 1UF3A 4DT2A 2QFRA 4O4KA 2WDDA 1OIEA 4KBPA 4YKEA 3HVQA 1M63A 1UTEA 5JPFA 3H68A 3THNA 4O5GA 1W24A 2IE4C 4FBWA 3KBPA 1Z2XA 3PSOA 3E0JA 3PSNA 3H62B 1G5BA 4FBKA 4UT3B 5GTUA 4JA7A 3EGGA 4M0VA 3RL4A 5DNYA 1TCOA 3CK2A 1OIDA 3DW8C 2HYOA 2JOGA 4JA9A 1T70A 4J6OA 3FGAC 4MOYA 3RL3A 1U32A 3JYFA 1Z2WA 3IVDA 4LTYA 4XPNA 2DXLA 1WAO1 5C1VA 2QFPA 2BCDA 4DSYA 2YEQA 4V0XA 4LU9A 4V0VA 2ZO9B 2IE3C 4OR9A 3ICFA 2WDFA 4ZX2A 2HY1A 4I5LC 1XZWA 4ORBA 3N5UA 4H2IA 4HD0A 4LACC 4I5NC 3LL8A 4MOVA 3RL5A 3H69A 1T71A 4O24A 3ZTVA 4TUIA 1SU1A 3P71C 4O43A 2QJCA 4FCXA 3IVEA 2WDCA 2BDXA 4DHLA 2DXNA 3GVEA 3AV0A 3H61A 1KBPA 4B2OA 2NYLC 3QFKA 4H1YP 3QFNA 3E7BA 3QFMA 4H2FA 2AHDA 5JJTA 1HPUA 2P6BA 1S3NA 3THOB 2NYMC 3V4YA 4UWQA 1QFCA 4H2BA 3H60A 3QG5C 3E7AA 1V73A 1S3LA 3TGHA 4F0ZA 3T1IA 1S3MA 3IB8A 2BQ8X 4ORCA 4G9JA 2ZOAA 1AUIA 5J28A 3DSCA 1MF8A 2NXFA 2Q8UA 3FLOA 5HPEA 1JK7A 2Z1AA 3H66A 3DSDA 1FJMA 2CV9A 1HP1A 2HYPA 3K7WC 4IYPC 4WWLA 4UT3A 2R17A 5JPEA 4H1SA 2O8GA 1IT6A 4TUGA
chains in the Genus database with same CATH topology
1USHA 2ZBMA 3C5WC 2Z72A 1QHWA 4ZVZA 3EGHA 3H64A 1II7A 1OI8A 3C9FA 5IOHA 3AUZA 4FBQA 2GJUA 3IB7A 5INBA 2IAEC 1S70A 1S95A 3QFOA 2KKNA 4UT2A 3ZU0A 5B8IA 1XM7A 3K7VC 3D03A 3RQZA 4KKZA 2O8AA 2NPPC 2WDEA 2YVTA 1HO5A 5F3WA 1S8EA 1WARA 3H67A 3H63A 4IL1A 4MP0A 4V0WA 2A22A 2XMOA 5EQVA 4ORAA 2Z06A 2DFJA 4H2GA 4NZVA 2USHA 1NNWA 4Q7FA 1UF3A 4DT2A 2QFRA 4O4KA 2WDDA 1OIEA 4KBPA 4YKEA 3HVQA 1M63A 1UTEA 5JPFA 3H68A 3THNA 4O5GA 1W24A 2IE4C 4FBWA 3KBPA 1Z2XA 3PSOA 3E0JA 3PSNA 3H62B 1G5BA 4FBKA 4UT3B 5GTUA 4JA7A 3EGGA 4M0VA 3RL4A 5DNYA 1TCOA 3CK2A 1OIDA 3DW8C 2HYOA 2JOGA 4JA9A 1T70A 4J6OA 3FGAC 4MOYA 3RL3A 1U32A 3JYFA 1Z2WA 3IVDA 4LTYA 4XPNA 2DXLA 1WAO1 5C1VA 2QFPA 2BCDA 4DSYA 2YEQA 4V0XA 4LU9A 4V0VA 2ZO9B 2IE3C 4OR9A 3ICFA 2WDFA 4ZX2A 2HY1A 4I5LC 1XZWA 4ORBA 3N5UA 4H2IA 4HD0A 4LACC 4I5NC 3LL8A 4MOVA 3RL5A 3H69A 1T71A 4O24A 3ZTVA 4TUIA 1SU1A 3P71C 4O43A 2QJCA 4FCXA 3IVEA 2WDCA 2BDXA 4DHLA 2DXNA 3GVEA 3AV0A 3H61A 1KBPA 4B2OA 2NYLC 3QFKA 4H1YP 3QFNA 3E7BA 3QFMA 4H2FA 2AHDA 5JJTA 1HPUA 2P6BA 1S3NA 3THOB 2NYMC 3V4YA 4UWQA 1QFCA 4H2BA 3H60A 3QG5C 3E7AA 1V73A 1S3LA 3TGHA 4F0ZA 3T1IA 1S3MA 3IB8A 2BQ8X 4ORCA 4G9JA 2ZOAA 1AUIA 5J28A 3DSCA 1MF8A 2NXFA 2Q8UA 3FLOA 5HPEA 1JK7A 2Z1AA 3H66A 3DSDA 1FJMA 2CV9A 1HP1A 2HYPA 3K7WC 4IYPC 4WWLA 4UT3A 2R17A 5JPEA 4H1SA 2O8GA 1IT6A 4TUGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1USH A;  2ZBM A;  3C5W C;  2Z72 A;  1QHW A;  4ZVZ A;  3EGH A;  3H64 A;  1II7 A;  1OI8 A;  3C9F A;  5IOH A;  3AUZ A;  4FBQ A;  2GJU A;  3IB7 A;  5INB A;  2IAE C;  1S70 A;  1S95 A;  3QFO A;  2KKN A;  4UT2 A;  3ZU0 A;  5B8I A;  1XM7 A;  3K7V C;  3RQZ A;  4KKZ A;  2O8A A;  2NPP C;  2WDE A;  2YVT A;  1HO5 A;  5F3W A;  1S8E A;  1WAR A;  3H67 A;  3H63 A;  4IL1 A;  4MP0 A;  4V0W A;  2A22 A;  2XMO A;  5EQV A;  4ORA A;  2Z06 A;  2DFJ A;  4H2G A;  4NZV A;  2USH A;  1NNW A;  4Q7F A;  1UF3 A;  4DT2 A;  2QFR A;  4O4K A;  2WDD A;  1OIE A;  4KBP A;  4YKE A;  3HVQ A;  1M63 A;  1UTE A;  5JPF A;  3H68 A;  3THN A;  4O5G A;  1W24 A;  2IE4 C;  4FBW A;  3KBP A;  1Z2X A;  3PSO A;  3PSN A;  3H62 B;  1G5B A;  4FBK A;  4UT3 B;  5GTU A;  4JA7 A;  3EGG A;  4M0V A;  3RL4 A;  5DNY A;  1TCO A;  3CK2 A;  1OID A;  3DW8 C;  2HYO A;  2JOG A;  4JA9 A;  1T70 A;  4J6O A;  3FGA C;  4MOY A;  3RL3 A;  1U32 A;  3JYF A;  1Z2W A;  3IVD A;  4LTY A;  4XPN A;  5C1V A;  1WAO 1;  2QFP A;  2BCD A;  4DSY A;  4V0X A;  4LU9 A;  4V0V A;  2IE3 C;  4OR9 A;  3ICF A;  2WDF A;  4ZX2 A;  2HY1 A;  4I5L C;  1XZW A;  4ORB A;  3N5U A;  4H2I A;  4HD0 A;  4LAC C;  4I5N C;  3LL8 A;  4MOV A;  3RL5 A;  3H69 A;  1T71 A;  4O24 A;  3ZTV A;  4TUI A;  1SU1 A;  3P71 C;  4O43 A;  2QJC A;  4FCX A;  3IVE A;  2WDC A;  2BDX A;  4DHL A;  3GVE A;  3AV0 A;  3H61 A;  1KBP A;  4B2O A;  2NYL C;  3QFK A;  4H1Y P;  3QFN A;  3E7B A;  3QFM A;  4H2F A;  2AHD A;  5JJT A;  1HPU A;  2P6B A;  1S3N A;  3THO B;  2NYM C;  3V4Y A;  4UWQ A;  1QFC A;  4H2B A;  3H60 A;  3QG5 C;  3E7A A;  1V73 A;  1S3L A;  3TGH A;  4F0Z A;  3T1I A;  1S3M A;  3IB8 A;  2BQ8 X;  4ORC A;  4G9J A;  1AUI A;  5J28 A;  3DSC A;  1MF8 A;  2NXF A;  2Q8U A;  5HPE A;  1JK7 A;  2Z1A A;  3H66 A;  3DSD A;  1FJM A;  2CV9 A;  1HP1 A;  2HYP A;  3K7W C;  4IYP C;  4WWL A;  4UT3 A;  2R17 A;  5JPE A;  4H1S A;  2O8G A;  1IT6 A;  4TUG A; 
#chains in the Genus database with same CATH topology
 1USH A;  2ZBM A;  3C5W C;  2Z72 A;  1QHW A;  4ZVZ A;  3EGH A;  3H64 A;  1II7 A;  1OI8 A;  3C9F A;  5IOH A;  3AUZ A;  4FBQ A;  2GJU A;  3IB7 A;  5INB A;  2IAE C;  1S70 A;  1S95 A;  3QFO A;  2KKN A;  4UT2 A;  3ZU0 A;  5B8I A;  1XM7 A;  3K7V C;  3D03 A;  3RQZ A;  4KKZ A;  2O8A A;  2NPP C;  2WDE A;  2YVT A;  1HO5 A;  5F3W A;  1S8E A;  1WAR A;  3H67 A;  3H63 A;  4IL1 A;  4MP0 A;  4V0W A;  2A22 A;  2XMO A;  5EQV A;  4ORA A;  2Z06 A;  2DFJ A;  4H2G A;  4NZV A;  2USH A;  1NNW A;  4Q7F A;  1UF3 A;  4DT2 A;  2QFR A;  4O4K A;  2WDD A;  1OIE A;  4KBP A;  4YKE A;  3HVQ A;  1M63 A;  1UTE A;  5JPF A;  3H68 A;  3THN A;  4O5G A;  1W24 A;  2IE4 C;  4FBW A;  3KBP A;  1Z2X A;  3PSO A;  3E0J A;  3PSN A;  3H62 B;  1G5B A;  4FBK A;  4UT3 B;  5GTU A;  4JA7 A;  3EGG A;  4M0V A;  3RL4 A;  5DNY A;  1TCO A;  3CK2 A;  1OID A;  3DW8 C;  2HYO A;  2JOG A;  4JA9 A;  1T70 A;  4J6O A;  3FGA C;  4MOY A;  3RL3 A;  1U32 A;  3JYF A;  1Z2W A;  3IVD A;  4LTY A;  4XPN A;  2DXL A;  1WAO 1;  5C1V A;  2QFP A;  2BCD A;  4DSY A;  2YEQ A;  4V0X A;  4LU9 A;  4V0V A;  2ZO9 B;  2IE3 C;  4OR9 A;  3ICF A;  2WDF A;  4ZX2 A;  2HY1 A;  4I5L C;  1XZW A;  4ORB A;  3N5U A;  4H2I A;  4HD0 A;  4LAC C;  4I5N C;  3LL8 A;  4MOV A;  3RL5 A;  3H69 A;  1T71 A;  4O24 A;  3ZTV A;  4TUI A;  1SU1 A;  3P71 C;  4O43 A;  2QJC A;  4FCX A;  3IVE A;  2WDC A;  2BDX A;  4DHL A;  2DXN A;  3GVE A;  3AV0 A;  3H61 A;  1KBP A;  4B2O A;  2NYL C;  3QFK A;  4H1Y P;  3QFN A;  3E7B A;  3QFM A;  4H2F A;  2AHD A;  5JJT A;  1HPU A;  2P6B A;  1S3N A;  3THO B;  2NYM C;  3V4Y A;  4UWQ A;  1QFC A;  4H2B A;  3H60 A;  3QG5 C;  3E7A A;  1V73 A;  1S3L A;  3TGH A;  4F0Z A;  3T1I A;  1S3M A;  3IB8 A;  2BQ8 X;  4ORC A;  4G9J A;  2ZOA A;  1AUI A;  5J28 A;  3DSC A;  1MF8 A;  2NXF A;  2Q8U A;  3FLO A;  5HPE A;  1JK7 A;  2Z1A A;  3H66 A;  3DSD A;  1FJM A;  2CV9 A;  1HP1 A;  2HYP A;  3K7W C;  4IYP C;  4WWL A;  4UT3 A;  2R17 A;  5JPE A;  4H1S A;  2O8G A;  1IT6 A;  4TUG A; 
#chains in the Genus database with same CATH homology
 1USH A;  2ZBM A;  3C5W C;  2Z72 A;  1QHW A;  4ZVZ A;  3EGH A;  3H64 A;  1II7 A;  1OI8 A;  3C9F A;  5IOH A;  3AUZ A;  4FBQ A;  2GJU A;  3IB7 A;  5INB A;  2IAE C;  1S70 A;  1S95 A;  3QFO A;  2KKN A;  4UT2 A;  3ZU0 A;  5B8I A;  1XM7 A;  3K7V C;  3D03 A;  3RQZ A;  4KKZ A;  2O8A A;  2NPP C;  2WDE A;  2YVT A;  1HO5 A;  5F3W A;  1S8E A;  1WAR A;  3H67 A;  3H63 A;  4IL1 A;  4MP0 A;  4V0W A;  2A22 A;  2XMO A;  5EQV A;  4ORA A;  2Z06 A;  2DFJ A;  4H2G A;  4NZV A;  2USH A;  1NNW A;  4Q7F A;  1UF3 A;  4DT2 A;  2QFR A;  4O4K A;  2WDD A;  1OIE A;  4KBP A;  4YKE A;  3HVQ A;  1M63 A;  1UTE A;  5JPF A;  3H68 A;  3THN A;  4O5G A;  1W24 A;  2IE4 C;  4FBW A;  3KBP A;  1Z2X A;  3PSO A;  3E0J A;  3PSN A;  3H62 B;  1G5B A;  4FBK A;  4UT3 B;  5GTU A;  4JA7 A;  3EGG A;  4M0V A;  3RL4 A;  5DNY A;  1TCO A;  3CK2 A;  1OID A;  3DW8 C;  2HYO A;  2JOG A;  4JA9 A;  1T70 A;  4J6O A;  3FGA C;  4MOY A;  3RL3 A;  1U32 A;  3JYF A;  1Z2W A;  3IVD A;  4LTY A;  4XPN A;  2DXL A;  1WAO 1;  5C1V A;  2QFP A;  2BCD A;  4DSY A;  2YEQ A;  4V0X A;  4LU9 A;  4V0V A;  2ZO9 B;  2IE3 C;  4OR9 A;  3ICF A;  2WDF A;  4ZX2 A;  2HY1 A;  4I5L C;  1XZW A;  4ORB A;  3N5U A;  4H2I A;  4HD0 A;  4LAC C;  4I5N C;  3LL8 A;  4MOV A;  3RL5 A;  3H69 A;  1T71 A;  4O24 A;  3ZTV A;  4TUI A;  1SU1 A;  3P71 C;  4O43 A;  2QJC A;  4FCX A;  3IVE A;  2WDC A;  2BDX A;  4DHL A;  2DXN A;  3GVE A;  3AV0 A;  3H61 A;  1KBP A;  4B2O A;  2NYL C;  3QFK A;  4H1Y P;  3QFN A;  3E7B A;  3QFM A;  4H2F A;  2AHD A;  5JJT A;  1HPU A;  2P6B A;  1S3N A;  3THO B;  2NYM C;  3V4Y A;  4UWQ A;  1QFC A;  4H2B A;  3H60 A;  3QG5 C;  3E7A A;  1V73 A;  1S3L A;  3TGH A;  4F0Z A;  3T1I A;  1S3M A;  3IB8 A;  2BQ8 X;  4ORC A;  4G9J A;  2ZOA A;  1AUI A;  5J28 A;  3DSC A;  1MF8 A;  2NXF A;  2Q8U A;  3FLO A;  5HPE A;  1JK7 A;  2Z1A A;  3H66 A;  3DSD A;  1FJM A;  2CV9 A;  1HP1 A;  2HYP A;  3K7W C;  4IYP C;  4WWL A;  4UT3 A;  2R17 A;  5JPE A;  4H1S A;  2O8G A;  1IT6 A;  4TUG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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