3CQZL

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
45
structure length
43
Chain Sequence
TLKYICAECSSKLSLSRTDAVRCCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 3
structure length 43
sequence length 45
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 3cqzL00
3S14L 2JA6L 4A3GL 4BY7L 5FLML 4C3HL 3PO3L 3GTOL 2JA7L 3HOUL 2E2IL 1K83L 3HOWL 4AYBP 2WAQP 3S1QL 4QIWP 2R93L 5C44L 3S2DL 5M5XL 2B63L 2JA5L 5FJ8L 4A3ML 3S2HL 4A3BL 2NVTL 4A3LL 2YU9L 1I6HL 3CQZL 5C3EL 1R9TL 1I3QL 3FKIL 2R92L 3GTQL 3GTGL 1TWCL 4A93L 1TWGL 3S1RL 3S1NL 1TWFL 4Y7NL 3GTLL 3HOYL 1Y1WL 3H0GL 1TWAL 4A3EL 2E2JL 5IP7L 3HOVL 4X6AL 5IYBL 3HOZL 1SFOL 2WB1P 3GTPL 4BY1L 3HKZP 1WCML 3RZDL 4A3CL 3S17L 5IYDL 4A3DL 2NVQL 1Y1VL 3RZOL 4BBSL 3PO2L 2NVYL 5IP9L 5C4JL 2VUML 4Y52L 3I4NL 3I4ML 5M3ML 3M4OL 3S15L 3M3YL 3S1ML 1I50L 5C4XL 5M3FL 5IYCL 2Y0SP 4C3JL 5M5WL 4A3JL 4A3KL 2JA8L 3GTKL 3K7AL 2E2HL 3GTML 4C3IL 3S16L 4A3IL 5M5YL 3H3VM 3GTJL 4C2M1 2R7ZL 2PMZP 3HOXL 2NVXL 4A3FL 4BBRL 4BXXL 1TWHL
chains in the Genus database with same CATH superfamily
1LTLA 4WFN1 1LKPA 5GADc 2JA6L 1PFWA 3ZG6A 4BY7L 3HOUL 4YWMA 1NXEA 3HOWL 2JI2A 3IU3I 1CAAA 1T9QA 4JAEA 5JVH1 2JA5L 1PFUA 3S2HL 2C6BA 2YU9L 2B5ID 1R0HA 3PWFA 1Z92B 3RZTA 3MQKB 5AI2A 3WWLA 1I3QL 1E8JA 3FKIL 3GTQL 1PFYA 5GAHc 1BRFA 1TWCL 1TWGL 3S1NL 3SS2A 1TWFL 1R0FA 1TWAL 1B2OA 2E2JL 5IP7L 4X6AL 5K2ME 5DM61 3RZDL 4A3DL 3PIO1 5IYDL 2NVQL 3LWRB 2V0EA 1WJVA 4Y52L 4GS7D 1QYBA 1RYQA 3S1ML 4LHLA 2DSXA 5C4XL 3P2AA 5M3FL 5IYCL 2Y0SP 2JI3A 4A3JL 4A3KL 1LKOA 2M4VA 3K7AL 8RXNA 2E2HL 3S16L 2XJQA 5M5YL 3KYUA 4YWLA 1B71A 3B0AB 2XJVA 3MPSA 3HOXL 1PFVA 4BXXL 2RFKB 1R0GA 1FHMA 3S14L 1ODHA 2PVXA 1IW7D 2J9UB 3HJWB 4RXNA 5FLML 3PO3L 2APOB 2ERJA 1B13A 1K83L 2MS3A 2WAQP 4ZN3B 5C44L 2LCQA 5FJ8L 4A3ML 2RDVA 5DM71 2XJPA 4A3LL 1YUZA 3LPEB 1SMUA 3KYYA 1IROA 2V0FA 3KYXA 2BE5D 2HVYC 4AI0A 3WWNB 3HAXC 3PZAA 4A93L 2AYJA 2XJSA 3LWOB 4A3EL 1S30A 3HOVL 2PSMC 2AQCA 3LWPB 1BFYA 1WCML 2XJRA 4AHXA 5C4JL 5M3ML 1S24A 3S15L 5MF6A 3PIP1 5EIOC 1RYTA 3MSUA 4C3JL 4B8CD 2Z3QB 5MFPA 1R0JA 2VL6A 4AR6A 4POFA 5AN9H 5MFZA 2QL0A 1P7PA 1S2ZA 2M6PA 5EINC 4K9FA 3PL5A 3S17L 1FHHA 2A6HD 3K35A 5IY0A 1JYBA 4C3HL 3GTOL 1BQ9A 4AYBP 4AI3A 4AR4A 4XXBB 5MLC3 2R93L 3S2DL 2JI1A 5M5XL 2B63L 3KYWA 4XGHA 2A68D 3PKJA 4A3BL 4JADA 2NVTL 3PKIA 3J7Z1 3CQZL 2A69D 2H12A 5C3EL 1R9TL 1DX8A 3KYVA 2R92L 3LWVB 2NYDA 3GTGL 2KN9A 2CR8A 3GTLL 3H0GL 2KKDA 1SMWA 4JAFA 4U671 1VCXA 3RYGA 1IU5A 2XJTA 3HOZL 1SFOL 1CADA 3GTPL 2GMGA 2V3BB 4BY1L 1BE7A 4A3CL 7RXNA 1QQTA 2NVYL 1LKMA 2M6OA 5GAEc 4AHYA 3I4NL 3M4OL 3M3YL 1B2JA 3B08B 2ZIXA 3J7Y1 2M4YA 1VZIA 4G6BA 2JA8L 3QVDA 2K2DA 2ERSA 3LWQB 1R0IA 3RZ6A 3H99A 4A3IL 1NNQA 3H97A 5GAGc 3LNLA 4AHZA 3HJYB 2CKAA 2PVEA 3NFPI 1IU6A 4A3FL 2XJUA 5MGNA 2PYAA 4A3GL 2JA7L 2E2IL 5H1Sc 4ME3A 3VPBE 3S1QL 2O5JD 2PPTA 4V196 3P8BA 4QIWP 3H9BA 1YK5A 1VZHA 1ZRPA 2L0ZA 4TVMA 1F4LA 2Z3RB 6RXNA 1I6HL 5JVG1 1H7VA 4UY81 4ZN1B 4AHWA 2CKCA 3A44A 1QCVA 3S1RL 4Y7NL 3HOYL 2C6AA 1NXGA 1Y1WL 1RDGA 5IYBL 2WB1P 1RWDA 1VZGA 2A6ED 3HKZP 4AR5A 1Y1VL 2AUSB 4AI1A 3RZOL 4BBSL 3PO2L 1OWBA 1YV1A 5IP9L 1RDVA 1PZXA 2VUML 4TPUA 3I4ML 1SMMA 3JR7A 1OWCA 1I50L 4JAGA 5RXNA 1DVBA 1IRNA 5M5WL 3GTKL 4AR3A 3GTML 4C3IL 4AI2A 1BQ8A 3FDJA 3H3VM 1T9OA 1YUXA 3GTJL 4C2M1 2R7ZL 1RB9A 1T9PA 4POGA 2PMZP 3H9CA 3QQCE 2NVXL 2HR5A 2EY4E 1C09A 1YK4A 4BBRL 4E6YA 5AI3A 4LHNA 1TWHL
chains in the Genus database with same CATH topology
3S14L 2JA6L 4A3GL 4BY7L 5FLML 4C3HL 3PO3L 3GTOL 2JA7L 3HOUL 2E2IL 1K83L 3HOWL 4AYBP 2WAQP 3S1QL 4QIWP 2R93L 5C44L 3S2DL 5M5XL 2B63L 2JA5L 5FJ8L 4A3ML 3S2HL 4A3BL 2NVTL 4A3LL 2YU9L 1I6HL 3CQZL 5C3EL 1R9TL 1I3QL 3FKIL 2R92L 3GTQL 3GTGL 1TWCL 4A93L 1TWGL 3S1RL 3S1NL 1TWFL 4Y7NL 3GTLL 3HOYL 1Y1WL 3H0GL 1TWAL 4A3EL 2E2JL 5IP7L 3HOVL 4X6AL 5IYBL 3HOZL 1SFOL 2WB1P 3GTPL 4BY1L 3HKZP 1WCML 3RZDL 4A3CL 3S17L 5IYDL 4A3DL 2NVQL 1Y1VL 3RZOL 4BBSL 3PO2L 2NVYL 5IP9L 5C4JL 2VUML 4Y52L 3I4NL 3I4ML 5M3ML 3M4OL 3S15L 3M3YL 3S1ML 1I50L 5C4XL 5M3FL 5IYCL 2Y0SP 4C3JL 5M5WL 4A3JL 4A3KL 2JA8L 3GTKL 3K7AL 2E2HL 3GTML 4C3IL 3S16L 4A3IL 5M5YL 3H3VM 3GTJL 4C2M1 2R7ZL 2PMZP 3HOXL 2NVXL 4A3FL 4BBRL 4BXXL 1TWHL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S14 L;  2JA6 L;  4A3G L;  4BY7 L;  5FLM L;  4C3H L;  3PO3 L;  3GTO L;  2JA7 L;  3HOU L;  2E2I L;  1K83 L;  3HOW L;  4AYB P;  2WAQ P;  3S1Q L;  4QIW P;  2R93 L;  5C44 L;  3S2D L;  5M5X L;  2B63 L;  2JA5 L;  5FJ8 L;  4A3M L;  3S2H L;  4A3B L;  2NVT L;  4A3L L;  2YU9 L;  1I6H L;  3CQZ L;  5C3E L;  1R9T L;  1I3Q L;  3FKI L;  2R92 L;  3GTQ L;  3GTG L;  1TWC L;  4A93 L;  1TWG L;  3S1R L;  3S1N L;  1TWF L;  4Y7N L;  3GTL L;  3HOY L;  1Y1W L;  3H0G L;  1TWA L;  4A3E L;  2E2J L;  5IP7 L;  3HOV L;  4X6A L;  5IYB L;  3HOZ L;  1SFO L;  2WB1 P;  3GTP L;  4BY1 L;  3HKZ P;  1WCM L;  3RZD L;  4A3C L;  3S17 L;  5IYD L;  4A3D L;  2NVQ L;  1Y1V L;  3RZO L;  4BBS L;  3PO2 L;  2NVY L;  5IP9 L;  5C4J L;  2VUM L;  4Y52 L;  3I4N L;  3I4M L;  5M3M L;  3M4O L;  3S15 L;  3M3Y L;  3S1M L;  1I50 L;  5C4X L;  5M3F L;  5IYC L;  2Y0S P;  4C3J L;  5M5W L;  4A3J L;  4A3K L;  2JA8 L;  3GTK L;  3K7A L;  2E2H L;  3GTM L;  4C3I L;  3S16 L;  4A3I L;  5M5Y L;  3H3V M;  3GTJ L;  4C2M 1;  2R7Z L;  2PMZ P;  3HOX L;  2NVX L;  4A3F L;  4BBR L;  4BXX L;  1TWH L; 
#chains in the Genus database with same CATH topology
 1LTL A;  4WFN 1;  1LKP A;  5GAD c;  2JA6 L;  1PFW A;  3ZG6 A;  4BY7 L;  3HOU L;  4YWM A;  1NXE A;  3HOW L;  2JI2 A;  3IU3 I;  1CAA A;  1T9Q A;  4JAE A;  5JVH 1;  2JA5 L;  1PFU A;  3S2H L;  2C6B A;  2YU9 L;  2B5I D;  1R0H A;  3PWF A;  1Z92 B;  3RZT A;  3MQK B;  5AI2 A;  3WWL A;  1I3Q L;  1E8J A;  3FKI L;  3GTQ L;  1PFY A;  5GAH c;  1BRF A;  1TWC L;  1TWG L;  3S1N L;  3SS2 A;  1TWF L;  1R0F A;  1TWA L;  1B2O A;  2E2J L;  5IP7 L;  4X6A L;  5K2M E;  5DM6 1;  3RZD L;  4A3D L;  3PIO 1;  5IYD L;  2NVQ L;  3LWR B;  2V0E A;  1WJV A;  4Y52 L;  4GS7 D;  1QYB A;  1RYQ A;  3S1M L;  4LHL A;  2DSX A;  5C4X L;  3P2A A;  5M3F L;  5IYC L;  2Y0S P;  2JI3 A;  4A3J L;  4A3K L;  1LKO A;  2M4V A;  3K7A L;  8RXN A;  2E2H L;  3S16 L;  2XJQ A;  5M5Y L;  3KYU A;  4YWL A;  1B71 A;  3B0A B;  2XJV A;  3MPS A;  3HOX L;  1PFV A;  4BXX L;  2RFK B;  1R0G A;  1FHM A;  3S14 L;  1ODH A;  2PVX A;  1IW7 D;  2J9U B;  3HJW B;  4RXN A;  5FLM L;  3PO3 L;  2APO B;  2ERJ A;  1B13 A;  1K83 L;  2MS3 A;  2WAQ P;  4ZN3 B;  5C44 L;  2LCQ A;  5FJ8 L;  4A3M L;  2RDV A;  5DM7 1;  2XJP A;  4A3L L;  1YUZ A;  3LPE B;  1SMU A;  3KYY A;  1IRO A;  2V0F A;  3KYX A;  2BE5 D;  2HVY C;  4AI0 A;  3WWN B;  3HAX C;  3PZA A;  4A93 L;  2AYJ A;  2XJS A;  3LWO B;  4A3E L;  1S30 A;  3HOV L;  2PSM C;  2AQC A;  3LWP B;  1BFY A;  1WCM L;  2XJR A;  4AHX A;  5C4J L;  5M3M L;  1S24 A;  3S15 L;  5MF6 A;  3PIP 1;  5EIO C;  1RYT A;  3MSU A;  4C3J L;  4B8C D;  2Z3Q B;  5MFP A;  1R0J A;  2VL6 A;  4AR6 A;  4POF A;  5AN9 H;  5MFZ A;  2QL0 A;  1P7P A;  1S2Z A;  2M6P A;  5EIN C;  4K9F A;  3PL5 A;  3S17 L;  1FHH A;  2A6H D;  3K35 A;  5IY0 A;  1JYB A;  4C3H L;  3GTO L;  1BQ9 A;  4AYB P;  4AI3 A;  4AR4 A;  4XXB B;  5MLC 3;  2R93 L;  3S2D L;  2JI1 A;  5M5X L;  2B63 L;  3KYW A;  4XGH A;  2A68 D;  3PKJ A;  4A3B L;  4JAD A;  2NVT L;  3PKI A;  3J7Z 1;  3CQZ L;  2A69 D;  2H12 A;  5C3E L;  1R9T L;  1DX8 A;  3KYV A;  2R92 L;  3LWV B;  2NYD A;  3GTG L;  2KN9 A;  2CR8 A;  3GTL L;  3H0G L;  2KKD A;  1SMW A;  4JAF A;  4U67 1;  1VCX A;  3RYG A;  1IU5 A;  2XJT A;  3HOZ L;  1SFO L;  1CAD A;  3GTP L;  2GMG A;  2V3B B;  4BY1 L;  1BE7 A;  4A3C L;  7RXN A;  1QQT A;  2NVY L;  1LKM A;  2M6O A;  5GAE c;  4AHY A;  3I4N L;  3M4O L;  3M3Y L;  1B2J A;  3B08 B;  2ZIX A;  3J7Y 1;  2M4Y A;  1VZI A;  4G6B A;  2JA8 L;  3QVD A;  2K2D A;  2ERS A;  3LWQ B;  1R0I A;  3RZ6 A;  3H99 A;  4A3I L;  1NNQ A;  3H97 A;  5GAG c;  3LNL A;  4AHZ A;  3HJY B;  2CKA A;  2PVE A;  3NFP I;  1IU6 A;  4A3F L;  2XJU A;  5MGN A;  2PYA A;  4A3G L;  2JA7 L;  2E2I L;  5H1S c;  4ME3 A;  3VPB E;  3S1Q L;  2O5J D;  2PPT A;  4V19 6;  3P8B A;  4QIW P;  3H9B A;  1YK5 A;  1VZH A;  1ZRP A;  2L0Z A;  4TVM A;  1F4L A;  2Z3R B;  6RXN A;  1I6H L;  5JVG 1;  1H7V A;  4UY8 1;  4ZN1 B;  4AHW A;  2CKC A;  3A44 A;  1QCV A;  3S1R L;  4Y7N L;  3HOY L;  2C6A A;  1NXG A;  1Y1W L;  1RDG A;  5IYB L;  2WB1 P;  1RWD A;  1VZG A;  2A6E D;  3HKZ P;  4AR5 A;  1Y1V L;  2AUS B;  4AI1 A;  3RZO L;  4BBS L;  3PO2 L;  1OWB A;  1YV1 A;  5IP9 L;  1RDV A;  1PZX A;  2VUM L;  4TPU A;  3I4M L;  1SMM A;  3JR7 A;  1OWC A;  1I50 L;  4JAG A;  5RXN A;  1DVB A;  1IRN A;  5M5W L;  3GTK L;  4AR3 A;  3GTM L;  4C3I L;  4AI2 A;  1BQ8 A;  3FDJ A;  3H3V M;  1T9O A;  1YUX A;  3GTJ L;  4C2M 1;  2R7Z L;  1RB9 A;  1T9P A;  4POG A;  2PMZ P;  3H9C A;  3QQC E;  2NVX L;  2HR5 A;  2EY4 E;  1C09 A;  1YK4 A;  4BBR L;  4E6Y A;  5AI3 A;  4LHN A;  1TWH L; 
#chains in the Genus database with same CATH homology
 3S14 L;  2JA6 L;  4A3G L;  4BY7 L;  5FLM L;  4C3H L;  3PO3 L;  3GTO L;  2JA7 L;  3HOU L;  2E2I L;  1K83 L;  3HOW L;  4AYB P;  2WAQ P;  3S1Q L;  4QIW P;  2R93 L;  5C44 L;  3S2D L;  5M5X L;  2B63 L;  2JA5 L;  5FJ8 L;  4A3M L;  3S2H L;  4A3B L;  2NVT L;  4A3L L;  2YU9 L;  1I6H L;  3CQZ L;  5C3E L;  1R9T L;  1I3Q L;  3FKI L;  2R92 L;  3GTQ L;  3GTG L;  1TWC L;  4A93 L;  1TWG L;  3S1R L;  3S1N L;  1TWF L;  4Y7N L;  3GTL L;  3HOY L;  1Y1W L;  3H0G L;  1TWA L;  4A3E L;  2E2J L;  5IP7 L;  3HOV L;  4X6A L;  5IYB L;  3HOZ L;  1SFO L;  2WB1 P;  3GTP L;  4BY1 L;  3HKZ P;  1WCM L;  3RZD L;  4A3C L;  3S17 L;  5IYD L;  4A3D L;  2NVQ L;  1Y1V L;  3RZO L;  4BBS L;  3PO2 L;  2NVY L;  5IP9 L;  5C4J L;  2VUM L;  4Y52 L;  3I4N L;  3I4M L;  5M3M L;  3M4O L;  3S15 L;  3M3Y L;  3S1M L;  1I50 L;  5C4X L;  5M3F L;  5IYC L;  2Y0S P;  4C3J L;  5M5W L;  4A3J L;  4A3K L;  2JA8 L;  3GTK L;  3K7A L;  2E2H L;  3GTM L;  4C3I L;  3S16 L;  4A3I L;  5M5Y L;  3H3V M;  3GTJ L;  4C2M 1;  2R7Z L;  2PMZ P;  3HOX L;  2NVX L;  4A3F L;  4BBR L;  4BXX L;  1TWH L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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