3CQZL

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
45
structure length
43
Chain Sequence
TLKYICAECSSKLSLSRTDAVRCCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 3
structure length 43
sequence length 45
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 3cqzL00
4A3JL 3S15L 4A3CL 4C3HL 2JA8L 4QIWP 5FLML 3RZOL 3RZDL 3PO3L 3HOXL 2E2HL 3S2HL 3HOZL 1I3QL 4A3FL 4A3GL 5M5XL 3GTKL 5C4XL 1TWCL 4A3EL 5IYDL 4A3DL 1Y1WL 3H0GL 3GTQL 2R93L 3CQZL 3FKIL 2R92L 4A3BL 3GTGL 4BBSL 4BY7L 3S2DL 2YU9L 5IP7L 2NVYL 4BY1L 3S1NL 1TWHL 1SFOL 3HKZP 5M5WL 2R7ZL 4A3IL 3K7AL 2NVXL 2NVTL 1WCML 5IYCL 2E2JL 5C4JL 4A3KL 2E2IL 5FJ8L 4Y7NL 4BXXL 3I4ML 4C3IL 4X6AL 2PMZP 3M4OL 3H3VM 3HOYL 2JA5L 3PO2L 4C2M1 5M5YL 5M3ML 2VUML 5M3FL 1Y1VL 2JA7L 4A93L 2JA6L 4BBRL 3S1ML 1TWAL 4A3ML 1R9TL 3GTJL 3GTML 3S16L 4AYBP 1TWGL 3GTPL 1I50L 3HOWL 5IP9L 1I6HL 1K83L 3S14L 4Y52L 2WAQP 3GTLL 2WB1P 3I4NL 2NVQL 3S1QL 3HOUL 3M3YL 5C3EL 3HOVL 5C44L 2Y0SP 1TWFL 4C3JL 3GTOL 3S17L 2B63L 3S1RL 4A3LL 5IYBL
chains in the Genus database with same CATH superfamily
3VPBE 3S15L 2J9UB 4AR6A 2JA8L 4RXNA 5FLML 4U671 3RZDL 3S2HL 1B2JA 1DVBA 2GMGA 3KYVA 5IYDL 2NYDA 3J7Z1 2R92L 4TPUA 3GTGL 4BY7L 4ZN3B 2K2DA 4BY1L 1B2OA 2V0EA 1OWBA 1DX8A 1TWHL 3HKZP 2A68D 4A3IL 3H97A 1WCML 5IYCL 2O5JD 2DSXA 8RXNA 3HJYB 1NNQA 3I4ML 6RXNA 3PKIA 3H3VM 3HOYL 1LKPA 4A93L 1F4LA 4BBRL 5H1Sc 4B8CD 1E8JA 3GTML 5AI2A 5JVG1 1PFVA 4AYBP 1I50L 3H9BA 5MLC3 1B71A 1IU5A 5MGNA 2XJTA 2Z3RB 3HAXC 3LWQB 4Y52L 1RB9A 3GTLL 5JVH1 2NVQL 4GS7D 7RXNA 2PVXA 5GAGc 1VZIA 1WJVA 2V0FA 1T9OA 3S17L 5IYBL 3LPEB 1YUZA 2KKDA 1BE7A 1RYTA 1YV1A 1P7PA 4A3CL 1QYBA 3B08B 4LHLA 5RXNA 4QIWP 3A44A 1I3QL 1B13A 1IW7D 5M5XL 1VCXA 5C4XL 5DM61 2M6OA 4AI0A 4A3EL 5IY0A 3QVDA 1FHMA 2R93L 3CQZL 3FKIL 4WFN1 5K2ME 1YUXA 1BFYA 1FHHA 1ZRPA 4BBSL 4POFA 2PPTA 3RYGA 2JI1A 1NXGA 5M5WL 1SMWA 3K7AL 2NVXL 2JI2A 4JADA 4XGHA 1JYBA 2APOB 4BXXL 4UY81 4X6AL 2PMZP 3M4OL 3P2AA 2JA5L 3PO2L 3ZG6A 4C2M1 5GAHc 5M5YL 3WWLA 5M3FL 1Y1VL 4AI1A 2XJSA 3MSUA 3S1ML 1TWAL 2PSMC 3PWFA 1PZXA 2MS3A 1T9PA 3GTPL 3LWOB 1S2ZA 2A6HD 3LNLA 1SMUA 2ERSA 5IP9L 4AHZA 1K83L 2KN9A 3KYYA 4E6YA 2WAQP 1QCVA 2VL6A 2WB1P 4XXBB 1S24A 3I4NL 3B0AB 2A6ED 2PYAA 3P8BA 3HOUL 4K9FA 3M3YL 1PFUA 2L0ZA 5C3EL 3PIO1 2Y0SP 1TWFL 4C3JL 3QQCE 2RDVA 4A3LL 2CKAA 2B5ID 1OWCA 4POGA 1R0JA 1YK4A 3NFPI 3RZTA 3HOXL 1RYQA 3HOZL 1H7VA 4A3GL 2XJUA 3FDJA 5EIOC 1TWCL 2ZIXA 1Y1WL 3H0GL 3GTQL 2XJVA 5AN9H 1YK5A 1BRFA 1PFYA 2CKCA 4A3BL 3JR7A 3H9CA 1BQ9A 3KYXA 3H99A 1LKMA 2YU9L 2NVYL 4JAGA 1SMMA 1SFOL 3K35A 4YWLA 1R0IA 3SS2A 4AI3A 2NVTL 2ERJA 2E2JL 5C4JL 4A3KL 2E2IL 5FJ8L 4C3IL 3LWVB 4AR5A 5DM71 4AI2A 5M3ML 2VUML 2JA6L 2RFKB 2CR8A 2XJQA 3PKJA 3J7Y1 4AHYA 3GTJL 5GAEc 4AR3A 1TWGL 2PVEA 1LKOA 2AYJA 1I6HL 1VZHA 4ME3A 1RDGA 1QQTA 4AR4A 2V3BB 3WWNB 3S1QL 4AHWA 1LTLA 1R0HA 5C44L 2XJRA 1RDVA 2B63L 1NXEA 4A3JL 1R0FA 3KYWA 4C3HL 3HJWB 4JAFA 1ODHA 3RZOL 3RZ6A 2M6PA 3PO3L 2A69D 2E2HL 5GADc 2Z3QB 4A3FL 1Z92B 3GTKL 4LHNA 1CADA 2XJPA 2H12A 4A3DL 2JI3A 1IU6A 1BQ8A 4AHXA 1VZGA 2M4VA 1R0GA 1T9QA 4ZN1B 3S2DL 5MF6A 5IP7L 3S1NL 2BE5D 1S30A 2R7ZL 3LWPB 4V196 3PIP1 2HVYC 2AQCA 4Y7NL 2AUSB 2LCQA 4JAEA 5MFZA 4YWMA 5MFPA 3KYUA 3LWRB 2JA7L 3MQKB 2HR5A 1RWDA 3PL5A 4A3ML 1R9TL 3IU3I 2C6BA 3S16L 2EY4E 3HOWL 2M4YA 2QL0A 5AI3A 1IROA 3S14L 3PZAA 1CAAA 1PFWA 4G6BA 4TVMA 1IRNA 3HOVL 1C09A 2C6AA 5EINC 3MPSA 3GTOL 3S1RL
chains in the Genus database with same CATH topology
4A3JL 3S15L 4A3CL 4C3HL 2JA8L 4QIWP 5FLML 3RZOL 3RZDL 3PO3L 3HOXL 2E2HL 3S2HL 3HOZL 1I3QL 4A3FL 4A3GL 5M5XL 3GTKL 5C4XL 1TWCL 4A3EL 5IYDL 4A3DL 1Y1WL 3H0GL 3GTQL 2R93L 3CQZL 3FKIL 2R92L 4A3BL 3GTGL 4BBSL 4BY7L 3S2DL 2YU9L 5IP7L 2NVYL 4BY1L 3S1NL 1TWHL 1SFOL 3HKZP 5M5WL 2R7ZL 4A3IL 3K7AL 2NVXL 2NVTL 1WCML 5IYCL 2E2JL 5C4JL 4A3KL 2E2IL 5FJ8L 4Y7NL 4BXXL 3I4ML 4C3IL 4X6AL 2PMZP 3M4OL 3H3VM 3HOYL 2JA5L 3PO2L 4C2M1 5M5YL 5M3ML 2VUML 5M3FL 1Y1VL 2JA7L 4A93L 2JA6L 4BBRL 3S1ML 1TWAL 4A3ML 1R9TL 3GTJL 3GTML 3S16L 4AYBP 1TWGL 3GTPL 1I50L 3HOWL 5IP9L 1I6HL 1K83L 3S14L 4Y52L 2WAQP 3GTLL 2WB1P 3I4NL 2NVQL 3S1QL 3HOUL 3M3YL 5C3EL 3HOVL 5C44L 2Y0SP 1TWFL 4C3JL 3GTOL 3S17L 2B63L 3S1RL 4A3LL 5IYBL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3J L;  3S15 L;  4A3C L;  4C3H L;  2JA8 L;  4QIW P;  5FLM L;  3RZO L;  3RZD L;  3PO3 L;  3HOX L;  2E2H L;  3S2H L;  3HOZ L;  1I3Q L;  4A3F L;  4A3G L;  5M5X L;  3GTK L;  5C4X L;  1TWC L;  4A3E L;  5IYD L;  4A3D L;  1Y1W L;  3H0G L;  3GTQ L;  2R93 L;  3CQZ L;  3FKI L;  2R92 L;  4A3B L;  3GTG L;  4BBS L;  4BY7 L;  3S2D L;  2YU9 L;  5IP7 L;  2NVY L;  4BY1 L;  3S1N L;  1TWH L;  1SFO L;  3HKZ P;  5M5W L;  2R7Z L;  4A3I L;  3K7A L;  2NVX L;  2NVT L;  1WCM L;  5IYC L;  2E2J L;  5C4J L;  4A3K L;  2E2I L;  5FJ8 L;  4Y7N L;  4BXX L;  3I4M L;  4C3I L;  4X6A L;  2PMZ P;  3M4O L;  3H3V M;  3HOY L;  2JA5 L;  3PO2 L;  4C2M 1;  5M5Y L;  5M3M L;  2VUM L;  5M3F L;  1Y1V L;  2JA7 L;  4A93 L;  2JA6 L;  4BBR L;  3S1M L;  1TWA L;  4A3M L;  1R9T L;  3GTJ L;  3GTM L;  3S16 L;  4AYB P;  1TWG L;  3GTP L;  1I50 L;  3HOW L;  5IP9 L;  1I6H L;  1K83 L;  3S14 L;  4Y52 L;  2WAQ P;  3GTL L;  2WB1 P;  3I4N L;  2NVQ L;  3S1Q L;  3HOU L;  3M3Y L;  5C3E L;  3HOV L;  5C44 L;  2Y0S P;  1TWF L;  4C3J L;  3GTO L;  3S17 L;  2B63 L;  3S1R L;  4A3L L;  5IYB L; 
#chains in the Genus database with same CATH topology
 3VPB E;  3S15 L;  2J9U B;  4AR6 A;  2JA8 L;  4RXN A;  5FLM L;  4U67 1;  3RZD L;  3S2H L;  1B2J A;  1DVB A;  2GMG A;  3KYV A;  5IYD L;  2NYD A;  3J7Z 1;  2R92 L;  4TPU A;  3GTG L;  4BY7 L;  4ZN3 B;  2K2D A;  4BY1 L;  1B2O A;  2V0E A;  1OWB A;  1DX8 A;  1TWH L;  3HKZ P;  2A68 D;  4A3I L;  3H97 A;  1WCM L;  5IYC L;  2O5J D;  2DSX A;  8RXN A;  3HJY B;  1NNQ A;  3I4M L;  6RXN A;  3PKI A;  3H3V M;  3HOY L;  1LKP A;  4A93 L;  1F4L A;  4BBR L;  5H1S c;  4B8C D;  1E8J A;  3GTM L;  5AI2 A;  5JVG 1;  1PFV A;  4AYB P;  1I50 L;  3H9B A;  5MLC 3;  1B71 A;  1IU5 A;  5MGN A;  2XJT A;  2Z3R B;  3HAX C;  3LWQ B;  4Y52 L;  1RB9 A;  3GTL L;  5JVH 1;  2NVQ L;  4GS7 D;  7RXN A;  2PVX A;  5GAG c;  1VZI A;  1WJV A;  2V0F A;  1T9O A;  3S17 L;  5IYB L;  3LPE B;  1YUZ A;  2KKD A;  1BE7 A;  1RYT A;  1YV1 A;  1P7P A;  4A3C L;  1QYB A;  3B08 B;  4LHL A;  5RXN A;  4QIW P;  3A44 A;  1I3Q L;  1B13 A;  1IW7 D;  5M5X L;  1VCX A;  5C4X L;  5DM6 1;  2M6O A;  4AI0 A;  4A3E L;  5IY0 A;  3QVD A;  1FHM A;  2R93 L;  3CQZ L;  3FKI L;  4WFN 1;  5K2M E;  1YUX A;  1BFY A;  1FHH A;  1ZRP A;  4BBS L;  4POF A;  2PPT A;  3RYG A;  2JI1 A;  1NXG A;  5M5W L;  1SMW A;  3K7A L;  2NVX L;  2JI2 A;  4JAD A;  4XGH A;  1JYB A;  2APO B;  4BXX L;  4UY8 1;  4X6A L;  2PMZ P;  3M4O L;  3P2A A;  2JA5 L;  3PO2 L;  3ZG6 A;  4C2M 1;  5GAH c;  5M5Y L;  3WWL A;  5M3F L;  1Y1V L;  4AI1 A;  2XJS A;  3MSU A;  3S1M L;  1TWA L;  2PSM C;  3PWF A;  1PZX A;  2MS3 A;  1T9P A;  3GTP L;  3LWO B;  1S2Z A;  2A6H D;  3LNL A;  1SMU A;  2ERS A;  5IP9 L;  4AHZ A;  1K83 L;  2KN9 A;  3KYY A;  4E6Y A;  2WAQ P;  1QCV A;  2VL6 A;  2WB1 P;  4XXB B;  1S24 A;  3I4N L;  3B0A B;  2A6E D;  2PYA A;  3P8B A;  3HOU L;  4K9F A;  3M3Y L;  1PFU A;  2L0Z A;  5C3E L;  3PIO 1;  2Y0S P;  1TWF L;  4C3J L;  3QQC E;  2RDV A;  4A3L L;  2CKA A;  2B5I D;  1OWC A;  4POG A;  1R0J A;  1YK4 A;  3NFP I;  3RZT A;  3HOX L;  1RYQ A;  3HOZ L;  1H7V A;  4A3G L;  2XJU A;  3FDJ A;  5EIO C;  1TWC L;  2ZIX A;  1Y1W L;  3H0G L;  3GTQ L;  2XJV A;  5AN9 H;  1YK5 A;  1BRF A;  1PFY A;  2CKC A;  4A3B L;  3JR7 A;  3H9C A;  1BQ9 A;  3KYX A;  3H99 A;  1LKM A;  2YU9 L;  2NVY L;  4JAG A;  1SMM A;  1SFO L;  3K35 A;  4YWL A;  1R0I A;  3SS2 A;  4AI3 A;  2NVT L;  2ERJ A;  2E2J L;  5C4J L;  4A3K L;  2E2I L;  5FJ8 L;  4C3I L;  3LWV B;  4AR5 A;  5DM7 1;  4AI2 A;  5M3M L;  2VUM L;  2JA6 L;  2RFK B;  2CR8 A;  2XJQ A;  3PKJ A;  3J7Y 1;  4AHY A;  3GTJ L;  5GAE c;  4AR3 A;  1TWG L;  2PVE A;  1LKO A;  2AYJ A;  1I6H L;  1VZH A;  4ME3 A;  1RDG A;  1QQT A;  4AR4 A;  2V3B B;  3WWN B;  3S1Q L;  4AHW A;  1LTL A;  1R0H A;  5C44 L;  2XJR A;  1RDV A;  2B63 L;  1NXE A;  4A3J L;  1R0F A;  3KYW A;  4C3H L;  3HJW B;  4JAF A;  1ODH A;  3RZO L;  3RZ6 A;  2M6P A;  3PO3 L;  2A69 D;  2E2H L;  5GAD c;  2Z3Q B;  4A3F L;  1Z92 B;  3GTK L;  4LHN A;  1CAD A;  2XJP A;  2H12 A;  4A3D L;  2JI3 A;  1IU6 A;  1BQ8 A;  4AHX A;  1VZG A;  2M4V A;  1R0G A;  1T9Q A;  4ZN1 B;  3S2D L;  5MF6 A;  5IP7 L;  3S1N L;  2BE5 D;  1S30 A;  2R7Z L;  3LWP B;  4V19 6;  3PIP 1;  2HVY C;  2AQC A;  4Y7N L;  2AUS B;  2LCQ A;  4JAE A;  5MFZ A;  4YWM A;  5MFP A;  3KYU A;  3LWR B;  2JA7 L;  3MQK B;  2HR5 A;  1RWD A;  3PL5 A;  4A3M L;  1R9T L;  3IU3 I;  2C6B A;  3S16 L;  2EY4 E;  3HOW L;  2M4Y A;  2QL0 A;  5AI3 A;  1IRO A;  3S14 L;  3PZA A;  1CAA A;  1PFW A;  4G6B A;  4TVM A;  1IRN A;  3HOV L;  1C09 A;  2C6A A;  5EIN C;  3MPS A;  3GTO L;  3S1R L; 
#chains in the Genus database with same CATH homology
 4A3J L;  3S15 L;  4A3C L;  4C3H L;  2JA8 L;  4QIW P;  5FLM L;  3RZO L;  3RZD L;  3PO3 L;  3HOX L;  2E2H L;  3S2H L;  3HOZ L;  1I3Q L;  4A3F L;  4A3G L;  5M5X L;  3GTK L;  5C4X L;  1TWC L;  4A3E L;  5IYD L;  4A3D L;  1Y1W L;  3H0G L;  3GTQ L;  2R93 L;  3CQZ L;  3FKI L;  2R92 L;  4A3B L;  3GTG L;  4BBS L;  4BY7 L;  3S2D L;  2YU9 L;  5IP7 L;  2NVY L;  4BY1 L;  3S1N L;  1TWH L;  1SFO L;  3HKZ P;  5M5W L;  2R7Z L;  4A3I L;  3K7A L;  2NVX L;  2NVT L;  1WCM L;  5IYC L;  2E2J L;  5C4J L;  4A3K L;  2E2I L;  5FJ8 L;  4Y7N L;  4BXX L;  3I4M L;  4C3I L;  4X6A L;  2PMZ P;  3M4O L;  3H3V M;  3HOY L;  2JA5 L;  3PO2 L;  4C2M 1;  5M5Y L;  5M3M L;  2VUM L;  5M3F L;  1Y1V L;  2JA7 L;  4A93 L;  2JA6 L;  4BBR L;  3S1M L;  1TWA L;  4A3M L;  1R9T L;  3GTJ L;  3GTM L;  3S16 L;  4AYB P;  1TWG L;  3GTP L;  1I50 L;  3HOW L;  5IP9 L;  1I6H L;  1K83 L;  3S14 L;  4Y52 L;  2WAQ P;  3GTL L;  2WB1 P;  3I4N L;  2NVQ L;  3S1Q L;  3HOU L;  3M3Y L;  5C3E L;  3HOV L;  5C44 L;  2Y0S P;  1TWF L;  4C3J L;  3GTO L;  3S17 L;  2B63 L;  3S1R L;  4A3L L;  5IYB L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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