3DW8C

Structure of a protein phosphatase 2a holoenzyme with b55 subunit
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 106
structure length 288
sequence length 288
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3dw8C00
2NYLC 3T1IA 2NPPC 2HY1A 4LACC 2WDEA 3H63A 5F3WA 4J6OA 1FJMA 4FBKA 4IYPC 4KBPA 3H69A 1T70A 4UT2A 1TCOA 4NZVA 4FCXA 2Q8UA 4ZVZA 3THNA 3DSCA 3RL3A 1WARA 3N5UA 1HO5A 4I5NC 1UTEA 3ZU0A 2QJCA 3EGGA 4ZX2A 3H61A 2HYPA 4MP0A 5JPFA 4UT3B 1S8EA 3QFKA 3TGHA 4HD0A 2ZBMA 1S3LA 4M0VA 1KBPA 1Z2WA 1OIEA 4O24A 3QFOA 1WAO1 5INBA 3IB8A 4UWQA 5DNYA 1QFCA 2R17A 2QFRA 3RL4A 1S95A 2XMOA 3H66A 4H2FA 4O5GA 2Z1AA 3PSNA 4DHLA 4B2OA 2WDFA 2IAEC 1NNWA 2AHDA 3E7AA 2Z72A 4DSYA 1JK7A 1IT6A 1G5BA 3ICFA 2O8AA 3CK2A 1AUIA 2A22A 4V0WA 4O43A 1HPUA 4H2GA 4LTYA 3E7BA 2BCDA 3DW8C 3JYFA 3THOB 3HVQA 3IVDA 4JA9A 3C9FA 4FBQA 2USHA 4LU9A 1MF8A 4V0VA 5EQVA 3H67A 4YKEA 3QFNA 2QFPA 1S70A 2KKNA 4H2BA 4I5LC 3V4YA 5JPEA 4O4KA 5HPEA 5GTUA 3GVEA 2GJUA 1T71A 4ORAA 1S3MA 1OI8A 3AUZA 3KBPA 4KKZA 2BQ8X 4FBWA 4ORCA 1M63A 1QHWA 2CV9A 3FGAC 1II7A 3QFMA 3K7VC 5C1VA 2P6BA 4ORBA 3ZTVA 4XPNA 4H1SA 2DFJA 2Z06A 1W24A 2O8GA 3IB7A 5IOHA 5B8IA 5J28A 2IE4C 4WWLA 1U32A 5JJTA 3C5WC 1USHA 2NYMC 4TUIA 4IL1A 4F0ZA 3H64A 2YVTA 1XZWA 1UF3A 3RL5A 4MOVA 3EGHA 3DSDA 4DT2A 1Z2XA 3P71C 3H68A 4H2IA 2WDCA 4JA7A 4MOYA 1OIDA 2WDDA 3QG5C 1HP1A 4Q7FA 1SU1A 3RQZA 4OR9A 2JOGA 3PSOA 4UT3A 3H62B 4TUGA 4V0XA 2NXFA 3LL8A 2IE3C 3H60A 1S3NA 4G9JA 2HYOA 2BDXA 4H1YP 3AV0A 1XM7A 3K7WC 3IVEA 1V73A
chains in the Genus database with same CATH superfamily
2NYLC 3T1IA 2NPPC 2HY1A 4LACC 2WDEA 3H63A 5F3WA 4J6OA 1FJMA 4FBKA 4IYPC 4KBPA 3H69A 1T70A 4UT2A 1TCOA 4NZVA 4FCXA 2YEQA 2Q8UA 4ZVZA 3THNA 3DSCA 3RL3A 1WARA 3N5UA 1HO5A 4I5NC 1UTEA 3ZU0A 2QJCA 3EGGA 4ZX2A 3H61A 3FLOA 2HYPA 4MP0A 5JPFA 4UT3B 1S8EA 3QFKA 3TGHA 4HD0A 2ZBMA 1S3LA 4M0VA 1KBPA 1Z2WA 1OIEA 4O24A 3QFOA 1WAO1 5INBA 3IB8A 4UWQA 5DNYA 1QFCA 2R17A 2QFRA 2DXLA 3RL4A 1S95A 2XMOA 3H66A 4H2FA 4O5GA 2Z1AA 3PSNA 4DHLA 4B2OA 2WDFA 2IAEC 1NNWA 2AHDA 3E7AA 2Z72A 4DSYA 1JK7A 1IT6A 1G5BA 3ICFA 2O8AA 3CK2A 1AUIA 2A22A 4V0WA 4O43A 1HPUA 4H2GA 4LTYA 3E7BA 2BCDA 3DW8C 3JYFA 3THOB 3HVQA 3IVDA 4JA9A 3C9FA 4FBQA 2USHA 4LU9A 1MF8A 4V0VA 5EQVA 3H67A 4YKEA 3QFNA 2QFPA 1S70A 2KKNA 4H2BA 4I5LC 3V4YA 5JPEA 2DXNA 4O4KA 5HPEA 5GTUA 3GVEA 2GJUA 1T71A 4ORAA 1S3MA 1OI8A 3AUZA 3KBPA 4KKZA 2BQ8X 4FBWA 4ORCA 1M63A 1QHWA 3D03A 2CV9A 3FGAC 1II7A 3QFMA 3K7VC 5C1VA 2P6BA 4ORBA 3ZTVA 4XPNA 4H1SA 2DFJA 2Z06A 1W24A 2O8GA 3IB7A 2ZO9B 5IOHA 5B8IA 5J28A 2IE4C 4WWLA 1U32A 5JJTA 3C5WC 1USHA 2NYMC 4TUIA 4IL1A 4F0ZA 3H64A 2YVTA 3E0JA 1XZWA 1UF3A 3RL5A 4MOVA 3EGHA 3DSDA 4DT2A 1Z2XA 3P71C 3H68A 4H2IA 2WDCA 4JA7A 4MOYA 1OIDA 2WDDA 3QG5C 1HP1A 4Q7FA 1SU1A 3RQZA 4OR9A 2JOGA 3PSOA 2ZOAA 4UT3A 3H62B 4TUGA 4V0XA 2NXFA 3LL8A 2IE3C 3H60A 1S3NA 4G9JA 2HYOA 2BDXA 4H1YP 3AV0A 1XM7A 3K7WC 3IVEA 1V73A
chains in the Genus database with same CATH topology
2NYLC 3T1IA 2NPPC 2HY1A 4LACC 2WDEA 3H63A 5F3WA 4J6OA 1FJMA 4FBKA 4IYPC 4KBPA 3H69A 1T70A 4UT2A 1TCOA 4NZVA 4FCXA 2YEQA 2Q8UA 4ZVZA 3THNA 3DSCA 3RL3A 1WARA 3N5UA 1HO5A 4I5NC 1UTEA 3ZU0A 2QJCA 3EGGA 4ZX2A 3H61A 3FLOA 2HYPA 4MP0A 5JPFA 4UT3B 1S8EA 3QFKA 3TGHA 4HD0A 2ZBMA 1S3LA 4M0VA 1KBPA 1Z2WA 1OIEA 4O24A 3QFOA 1WAO1 5INBA 3IB8A 4UWQA 5DNYA 1QFCA 2R17A 2QFRA 2DXLA 3RL4A 1S95A 2XMOA 3H66A 4H2FA 4O5GA 2Z1AA 3PSNA 4DHLA 4B2OA 2WDFA 2IAEC 1NNWA 2AHDA 3E7AA 2Z72A 4DSYA 1JK7A 1IT6A 1G5BA 3ICFA 2O8AA 3CK2A 1AUIA 2A22A 4V0WA 4O43A 1HPUA 4H2GA 4LTYA 3E7BA 2BCDA 3DW8C 3JYFA 3THOB 3HVQA 3IVDA 4JA9A 3C9FA 4FBQA 2USHA 4LU9A 1MF8A 4V0VA 5EQVA 3H67A 4YKEA 3QFNA 2QFPA 1S70A 2KKNA 4H2BA 4I5LC 3V4YA 5JPEA 2DXNA 4O4KA 5HPEA 5GTUA 3GVEA 2GJUA 1T71A 4ORAA 1S3MA 1OI8A 3AUZA 3KBPA 4KKZA 2BQ8X 4FBWA 4ORCA 1M63A 1QHWA 3D03A 2CV9A 3FGAC 1II7A 3QFMA 3K7VC 5C1VA 2P6BA 4ORBA 3ZTVA 4XPNA 4H1SA 2DFJA 2Z06A 1W24A 2O8GA 3IB7A 2ZO9B 5IOHA 5B8IA 5J28A 2IE4C 4WWLA 1U32A 5JJTA 3C5WC 1USHA 2NYMC 4TUIA 4IL1A 4F0ZA 3H64A 2YVTA 3E0JA 1XZWA 1UF3A 3RL5A 4MOVA 3EGHA 3DSDA 4DT2A 1Z2XA 3P71C 3H68A 4H2IA 2WDCA 4JA7A 4MOYA 1OIDA 2WDDA 3QG5C 1HP1A 4Q7FA 1SU1A 3RQZA 4OR9A 2JOGA 3PSOA 2ZOAA 4UT3A 3H62B 4TUGA 4V0XA 2NXFA 3LL8A 2IE3C 3H60A 1S3NA 4G9JA 2HYOA 2BDXA 4H1YP 3AV0A 1XM7A 3K7WC 3IVEA 1V73A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYL C;  3T1I A;  2NPP C;  2HY1 A;  4LAC C;  2WDE A;  3H63 A;  5F3W A;  4J6O A;  1FJM A;  4FBK A;  4IYP C;  4KBP A;  3H69 A;  1T70 A;  4UT2 A;  1TCO A;  4NZV A;  4FCX A;  2Q8U A;  4ZVZ A;  3THN A;  3DSC A;  3RL3 A;  1WAR A;  3N5U A;  1HO5 A;  4I5N C;  1UTE A;  3ZU0 A;  2QJC A;  3EGG A;  4ZX2 A;  3H61 A;  2HYP A;  4MP0 A;  5JPF A;  4UT3 B;  1S8E A;  3QFK A;  3TGH A;  4HD0 A;  2ZBM A;  1S3L A;  4M0V A;  1KBP A;  1Z2W A;  1OIE A;  4O24 A;  3QFO A;  1WAO 1;  5INB A;  3IB8 A;  4UWQ A;  5DNY A;  1QFC A;  2R17 A;  2QFR A;  3RL4 A;  1S95 A;  2XMO A;  3H66 A;  4H2F A;  4O5G A;  2Z1A A;  3PSN A;  4DHL A;  4B2O A;  2WDF A;  2IAE C;  1NNW A;  2AHD A;  3E7A A;  2Z72 A;  4DSY A;  1JK7 A;  1IT6 A;  1G5B A;  3ICF A;  2O8A A;  3CK2 A;  1AUI A;  2A22 A;  4V0W A;  4O43 A;  1HPU A;  4H2G A;  4LTY A;  3E7B A;  2BCD A;  3DW8 C;  3JYF A;  3THO B;  3HVQ A;  3IVD A;  4JA9 A;  3C9F A;  4FBQ A;  2USH A;  4LU9 A;  1MF8 A;  4V0V A;  5EQV A;  3H67 A;  4YKE A;  3QFN A;  2QFP A;  1S70 A;  2KKN A;  4H2B A;  4I5L C;  3V4Y A;  5JPE A;  4O4K A;  5HPE A;  5GTU A;  3GVE A;  2GJU A;  1T71 A;  4ORA A;  1S3M A;  1OI8 A;  3AUZ A;  3KBP A;  4KKZ A;  2BQ8 X;  4FBW A;  4ORC A;  1M63 A;  1QHW A;  2CV9 A;  3FGA C;  1II7 A;  3QFM A;  3K7V C;  5C1V A;  2P6B A;  4ORB A;  3ZTV A;  4XPN A;  4H1S A;  2DFJ A;  2Z06 A;  1W24 A;  2O8G A;  3IB7 A;  5IOH A;  5B8I A;  5J28 A;  2IE4 C;  4WWL A;  1U32 A;  5JJT A;  3C5W C;  1USH A;  2NYM C;  4TUI A;  4IL1 A;  4F0Z A;  3H64 A;  2YVT A;  1XZW A;  1UF3 A;  3RL5 A;  4MOV A;  3EGH A;  3DSD A;  4DT2 A;  1Z2X A;  3P71 C;  3H68 A;  4H2I A;  2WDC A;  4JA7 A;  4MOY A;  1OID A;  2WDD A;  3QG5 C;  1HP1 A;  4Q7F A;  1SU1 A;  3RQZ A;  4OR9 A;  2JOG A;  3PSO A;  4UT3 A;  3H62 B;  4TUG A;  4V0X A;  2NXF A;  3LL8 A;  2IE3 C;  3H60 A;  1S3N A;  4G9J A;  2HYO A;  2BDX A;  4H1Y P;  3AV0 A;  1XM7 A;  3K7W C;  3IVE A;  1V73 A; 
#chains in the Genus database with same CATH topology
 2NYL C;  3T1I A;  2NPP C;  2HY1 A;  4LAC C;  2WDE A;  3H63 A;  5F3W A;  4J6O A;  1FJM A;  4FBK A;  4IYP C;  4KBP A;  3H69 A;  1T70 A;  4UT2 A;  1TCO A;  4NZV A;  4FCX A;  2YEQ A;  2Q8U A;  4ZVZ A;  3THN A;  3DSC A;  3RL3 A;  1WAR A;  3N5U A;  1HO5 A;  4I5N C;  1UTE A;  3ZU0 A;  2QJC A;  3EGG A;  4ZX2 A;  3H61 A;  3FLO A;  2HYP A;  4MP0 A;  5JPF A;  4UT3 B;  1S8E A;  3QFK A;  3TGH A;  4HD0 A;  2ZBM A;  1S3L A;  4M0V A;  1KBP A;  1Z2W A;  1OIE A;  4O24 A;  3QFO A;  1WAO 1;  5INB A;  3IB8 A;  4UWQ A;  5DNY A;  1QFC A;  2R17 A;  2QFR A;  2DXL A;  3RL4 A;  1S95 A;  2XMO A;  3H66 A;  4H2F A;  4O5G A;  2Z1A A;  3PSN A;  4DHL A;  4B2O A;  2WDF A;  2IAE C;  1NNW A;  2AHD A;  3E7A A;  2Z72 A;  4DSY A;  1JK7 A;  1IT6 A;  1G5B A;  3ICF A;  2O8A A;  3CK2 A;  1AUI A;  2A22 A;  4V0W A;  4O43 A;  1HPU A;  4H2G A;  4LTY A;  3E7B A;  2BCD A;  3DW8 C;  3JYF A;  3THO B;  3HVQ A;  3IVD A;  4JA9 A;  3C9F A;  4FBQ A;  2USH A;  4LU9 A;  1MF8 A;  4V0V A;  5EQV A;  3H67 A;  4YKE A;  3QFN A;  2QFP A;  1S70 A;  2KKN A;  4H2B A;  4I5L C;  3V4Y A;  5JPE A;  2DXN A;  4O4K A;  5HPE A;  5GTU A;  3GVE A;  2GJU A;  1T71 A;  4ORA A;  1S3M A;  1OI8 A;  3AUZ A;  3KBP A;  4KKZ A;  2BQ8 X;  4FBW A;  4ORC A;  1M63 A;  1QHW A;  3D03 A;  2CV9 A;  3FGA C;  1II7 A;  3QFM A;  3K7V C;  5C1V A;  2P6B A;  4ORB A;  3ZTV A;  4XPN A;  4H1S A;  2DFJ A;  2Z06 A;  1W24 A;  2O8G A;  3IB7 A;  2ZO9 B;  5IOH A;  5B8I A;  5J28 A;  2IE4 C;  4WWL A;  1U32 A;  5JJT A;  3C5W C;  1USH A;  2NYM C;  4TUI A;  4IL1 A;  4F0Z A;  3H64 A;  2YVT A;  3E0J A;  1XZW A;  1UF3 A;  3RL5 A;  4MOV A;  3EGH A;  3DSD A;  4DT2 A;  1Z2X A;  3P71 C;  3H68 A;  4H2I A;  2WDC A;  4JA7 A;  4MOY A;  1OID A;  2WDD A;  3QG5 C;  1HP1 A;  4Q7F A;  1SU1 A;  3RQZ A;  4OR9 A;  2JOG A;  3PSO A;  2ZOA A;  4UT3 A;  3H62 B;  4TUG A;  4V0X A;  2NXF A;  3LL8 A;  2IE3 C;  3H60 A;  1S3N A;  4G9J A;  2HYO A;  2BDX A;  4H1Y P;  3AV0 A;  1XM7 A;  3K7W C;  3IVE A;  1V73 A; 
#chains in the Genus database with same CATH homology
 2NYL C;  3T1I A;  2NPP C;  2HY1 A;  4LAC C;  2WDE A;  3H63 A;  5F3W A;  4J6O A;  1FJM A;  4FBK A;  4IYP C;  4KBP A;  3H69 A;  1T70 A;  4UT2 A;  1TCO A;  4NZV A;  4FCX A;  2YEQ A;  2Q8U A;  4ZVZ A;  3THN A;  3DSC A;  3RL3 A;  1WAR A;  3N5U A;  1HO5 A;  4I5N C;  1UTE A;  3ZU0 A;  2QJC A;  3EGG A;  4ZX2 A;  3H61 A;  3FLO A;  2HYP A;  4MP0 A;  5JPF A;  4UT3 B;  1S8E A;  3QFK A;  3TGH A;  4HD0 A;  2ZBM A;  1S3L A;  4M0V A;  1KBP A;  1Z2W A;  1OIE A;  4O24 A;  3QFO A;  1WAO 1;  5INB A;  3IB8 A;  4UWQ A;  5DNY A;  1QFC A;  2R17 A;  2QFR A;  2DXL A;  3RL4 A;  1S95 A;  2XMO A;  3H66 A;  4H2F A;  4O5G A;  2Z1A A;  3PSN A;  4DHL A;  4B2O A;  2WDF A;  2IAE C;  1NNW A;  2AHD A;  3E7A A;  2Z72 A;  4DSY A;  1JK7 A;  1IT6 A;  1G5B A;  3ICF A;  2O8A A;  3CK2 A;  1AUI A;  2A22 A;  4V0W A;  4O43 A;  1HPU A;  4H2G A;  4LTY A;  3E7B A;  2BCD A;  3DW8 C;  3JYF A;  3THO B;  3HVQ A;  3IVD A;  4JA9 A;  3C9F A;  4FBQ A;  2USH A;  4LU9 A;  1MF8 A;  4V0V A;  5EQV A;  3H67 A;  4YKE A;  3QFN A;  2QFP A;  1S70 A;  2KKN A;  4H2B A;  4I5L C;  3V4Y A;  5JPE A;  2DXN A;  4O4K A;  5HPE A;  5GTU A;  3GVE A;  2GJU A;  1T71 A;  4ORA A;  1S3M A;  1OI8 A;  3AUZ A;  3KBP A;  4KKZ A;  2BQ8 X;  4FBW A;  4ORC A;  1M63 A;  1QHW A;  3D03 A;  2CV9 A;  3FGA C;  1II7 A;  3QFM A;  3K7V C;  5C1V A;  2P6B A;  4ORB A;  3ZTV A;  4XPN A;  4H1S A;  2DFJ A;  2Z06 A;  1W24 A;  2O8G A;  3IB7 A;  2ZO9 B;  5IOH A;  5B8I A;  5J28 A;  2IE4 C;  4WWL A;  1U32 A;  5JJT A;  3C5W C;  1USH A;  2NYM C;  4TUI A;  4IL1 A;  4F0Z A;  3H64 A;  2YVT A;  3E0J A;  1XZW A;  1UF3 A;  3RL5 A;  4MOV A;  3EGH A;  3DSD A;  4DT2 A;  1Z2X A;  3P71 C;  3H68 A;  4H2I A;  2WDC A;  4JA7 A;  4MOY A;  1OID A;  2WDD A;  3QG5 C;  1HP1 A;  4Q7F A;  1SU1 A;  3RQZ A;  4OR9 A;  2JOG A;  3PSO A;  2ZOA A;  4UT3 A;  3H62 B;  4TUG A;  4V0X A;  2NXF A;  3LL8 A;  2IE3 C;  3H60 A;  1S3N A;  4G9J A;  2HYO A;  2BDX A;  4H1Y P;  3AV0 A;  1XM7 A;  3K7W C;  3IVE A;  1V73 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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