3E7AA

Crystal structure of protein phosphatase-1 bound to the natural toxin nodularin-r
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
293
structure length
293
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 110
structure length 293
sequence length 293
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3e7aA00
2Z72A 3K7WC 2NXFA 2IAEC 4ZX2A 1QFCA 3V4YA 2ZBMA 3RL5A 3QFKA 2AHDA 4ORCA 4H2GA 5INBA 4MOYA 1HPUA 4NZVA 4I5NC 4H2BA 1HP1A 3EGGA 1OIEA 1IT6A 1WAO1 1MF8A 1AUIA 3RL3A 3N5UA 3AV0A 2USHA 2Q8UA 4MOVA 3TGHA 1QHWA 2A22A 2BCDA 4TUIA 2HYOA 4H1YP 3LL8A 4FBKA 4O24A 1WARA 3IB8A 1U32A 4UWQA 3THOB 3IB7A 3K7VC 1HO5A 1TCOA 3T1IA 1Z2XA 4LACC 4UT3B 3PSNA 3E7AA 1S3NA 2NPPC 4HD0A 1UF3A 1S70A 3ZU0A 3DW8C 1JK7A 1II7A 4KBPA 2XMOA 4B2OA 4H1SA 3PSOA 3C9FA 5IOHA 2Z06A 4O4KA 1S95A 4JA9A 3GVEA 2IE4C 4ORAA 4FBQA 3H60A 3H69A 4DT2A 4FBWA 3DSDA 4YKEA 5EQVA 2YVTA 2NYLC 2O8GA 3HVQA 4J6OA 1M63A 3H63A 5F3WA 3QFNA 3H68A 2KKNA 3DSCA 2Z1AA 2BDXA 3IVEA 2P6BA 2GJUA 4Q7FA 2WDDA 3P71C 4LU9A 4O5GA 4JA7A 4V0WA 5GTUA 4H2IA 1SU1A 5C1VA 4V0XA 4TUGA 2WDFA 4FCXA 2QFRA 3IVDA 5J28A 4V0VA 2HY1A 3E7BA 5B8IA 3H64A 2DFJA 4DSYA 4WWLA 1T70A 1USHA 4IYPC 4H2FA 1KBPA 4IL1A 1XM7A 2HYPA 4O43A 2BQ8X 3QG5C 3H67A 3RL4A 4MP0A 3H66A 3ICFA 2CV9A 4G9JA 4XPNA 3EGHA 1OI8A 3C5WC 3QFMA 2QJCA 1Z2WA 3H61A 1G5BA 2O8AA 1T71A 3KBPA 4UT3A 1S3MA 3ZTVA 1S3LA 2IE3C 4M0VA 5JJTA 4F0ZA 1V73A 4I5LC 5DNYA 1W24A 3H62B 4OR9A 5HPEA 2QFPA 2JOGA 1FJMA 1OIDA 1S8EA 5JPFA 4ZVZA 3AUZA 4ORBA 4KKZA 3FGAC 4LTYA 3RQZA 4UT2A 2WDEA 4DHLA 1NNWA 3THNA 1UTEA 1XZWA 3CK2A 3JYFA 2R17A 2NYMC 5JPEA 3QFOA 2WDCA
chains in the Genus database with same CATH superfamily
2Z72A 3K7WC 2NXFA 2IAEC 4ZX2A 1QFCA 3V4YA 2ZBMA 3RL5A 3QFKA 2AHDA 4ORCA 4H2GA 5INBA 4MOYA 1HPUA 4NZVA 4I5NC 4H2BA 1HP1A 3EGGA 1OIEA 1IT6A 2DXNA 1WAO1 1MF8A 1AUIA 3RL3A 3N5UA 3AV0A 2USHA 2Q8UA 4MOVA 3TGHA 1QHWA 2A22A 2BCDA 3FLOA 4TUIA 2HYOA 4H1YP 3LL8A 4FBKA 4O24A 1WARA 3IB8A 1U32A 4UWQA 3THOB 3IB7A 3K7VC 1HO5A 1TCOA 3T1IA 2YEQA 1Z2XA 4LACC 4UT3B 3PSNA 3E7AA 1S3NA 2NPPC 4HD0A 1UF3A 1S70A 2ZOAA 3ZU0A 3DW8C 1JK7A 1II7A 4KBPA 2XMOA 4B2OA 4H1SA 3PSOA 3C9FA 3E0JA 5IOHA 2Z06A 4O4KA 1S95A 4JA9A 3GVEA 2IE4C 4ORAA 4FBQA 3H60A 3H69A 4DT2A 4FBWA 3DSDA 4YKEA 5EQVA 2YVTA 2NYLC 2O8GA 3HVQA 2ZO9B 4J6OA 1M63A 3H63A 5F3WA 3QFNA 3H68A 2KKNA 3DSCA 2Z1AA 2BDXA 3IVEA 2P6BA 2GJUA 4Q7FA 2WDDA 3P71C 4LU9A 4O5GA 4JA7A 4V0WA 5GTUA 4H2IA 1SU1A 5C1VA 3D03A 4V0XA 4TUGA 2WDFA 4FCXA 2QFRA 3IVDA 5J28A 4V0VA 2HY1A 3E7BA 5B8IA 3H64A 2DFJA 4DSYA 4WWLA 1T70A 1USHA 4IYPC 4H2FA 1KBPA 4IL1A 1XM7A 2HYPA 4O43A 2BQ8X 3QG5C 3H67A 3RL4A 4MP0A 3H66A 3ICFA 2CV9A 4G9JA 4XPNA 3EGHA 1OI8A 3C5WC 3QFMA 2QJCA 1Z2WA 3H61A 2DXLA 1G5BA 2O8AA 1T71A 3KBPA 4UT3A 1S3MA 3ZTVA 1S3LA 2IE3C 4M0VA 5JJTA 4F0ZA 1V73A 4I5LC 5DNYA 1W24A 3H62B 4OR9A 5HPEA 2QFPA 2JOGA 1FJMA 1OIDA 1S8EA 5JPFA 4ZVZA 3AUZA 4ORBA 4KKZA 3FGAC 4LTYA 3RQZA 4UT2A 2WDEA 4DHLA 1NNWA 3THNA 1UTEA 1XZWA 3CK2A 3JYFA 2R17A 2NYMC 5JPEA 3QFOA 2WDCA
chains in the Genus database with same CATH topology
2Z72A 3K7WC 2NXFA 2IAEC 4ZX2A 1QFCA 3V4YA 2ZBMA 3RL5A 3QFKA 2AHDA 4ORCA 4H2GA 5INBA 4MOYA 1HPUA 4NZVA 4I5NC 4H2BA 1HP1A 3EGGA 1OIEA 1IT6A 2DXNA 1WAO1 1MF8A 1AUIA 3RL3A 3N5UA 3AV0A 2USHA 2Q8UA 4MOVA 3TGHA 1QHWA 2A22A 2BCDA 3FLOA 4TUIA 2HYOA 4H1YP 3LL8A 4FBKA 4O24A 1WARA 3IB8A 1U32A 4UWQA 3THOB 3IB7A 3K7VC 1HO5A 1TCOA 3T1IA 2YEQA 1Z2XA 4LACC 4UT3B 3PSNA 3E7AA 1S3NA 2NPPC 4HD0A 1UF3A 1S70A 2ZOAA 3ZU0A 3DW8C 1JK7A 1II7A 4KBPA 2XMOA 4B2OA 4H1SA 3PSOA 3C9FA 3E0JA 5IOHA 2Z06A 4O4KA 1S95A 4JA9A 3GVEA 2IE4C 4ORAA 4FBQA 3H60A 3H69A 4DT2A 4FBWA 3DSDA 4YKEA 5EQVA 2YVTA 2NYLC 2O8GA 3HVQA 2ZO9B 4J6OA 1M63A 3H63A 5F3WA 3QFNA 3H68A 2KKNA 3DSCA 2Z1AA 2BDXA 3IVEA 2P6BA 2GJUA 4Q7FA 2WDDA 3P71C 4LU9A 4O5GA 4JA7A 4V0WA 5GTUA 4H2IA 1SU1A 5C1VA 3D03A 4V0XA 4TUGA 2WDFA 4FCXA 2QFRA 3IVDA 5J28A 4V0VA 2HY1A 3E7BA 5B8IA 3H64A 2DFJA 4DSYA 4WWLA 1T70A 1USHA 4IYPC 4H2FA 1KBPA 4IL1A 1XM7A 2HYPA 4O43A 2BQ8X 3QG5C 3H67A 3RL4A 4MP0A 3H66A 3ICFA 2CV9A 4G9JA 4XPNA 3EGHA 1OI8A 3C5WC 3QFMA 2QJCA 1Z2WA 3H61A 2DXLA 1G5BA 2O8AA 1T71A 3KBPA 4UT3A 1S3MA 3ZTVA 1S3LA 2IE3C 4M0VA 5JJTA 4F0ZA 1V73A 4I5LC 5DNYA 1W24A 3H62B 4OR9A 5HPEA 2QFPA 2JOGA 1FJMA 1OIDA 1S8EA 5JPFA 4ZVZA 3AUZA 4ORBA 4KKZA 3FGAC 4LTYA 3RQZA 4UT2A 2WDEA 4DHLA 1NNWA 3THNA 1UTEA 1XZWA 3CK2A 3JYFA 2R17A 2NYMC 5JPEA 3QFOA 2WDCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z72 A;  3K7W C;  2NXF A;  2IAE C;  4ZX2 A;  1QFC A;  3V4Y A;  2ZBM A;  3RL5 A;  3QFK A;  2AHD A;  4ORC A;  4H2G A;  5INB A;  4MOY A;  1HPU A;  4NZV A;  4I5N C;  4H2B A;  1HP1 A;  3EGG A;  1OIE A;  1IT6 A;  1WAO 1;  1MF8 A;  1AUI A;  3RL3 A;  3N5U A;  3AV0 A;  2USH A;  2Q8U A;  4MOV A;  3TGH A;  1QHW A;  2A22 A;  2BCD A;  4TUI A;  2HYO A;  4H1Y P;  3LL8 A;  4FBK A;  4O24 A;  1WAR A;  3IB8 A;  1U32 A;  4UWQ A;  3THO B;  3IB7 A;  3K7V C;  1HO5 A;  1TCO A;  3T1I A;  1Z2X A;  4LAC C;  4UT3 B;  3PSN A;  3E7A A;  1S3N A;  2NPP C;  4HD0 A;  1UF3 A;  1S70 A;  3ZU0 A;  3DW8 C;  1JK7 A;  1II7 A;  4KBP A;  2XMO A;  4B2O A;  4H1S A;  3PSO A;  3C9F A;  5IOH A;  2Z06 A;  4O4K A;  1S95 A;  4JA9 A;  3GVE A;  2IE4 C;  4ORA A;  4FBQ A;  3H60 A;  3H69 A;  4DT2 A;  4FBW A;  3DSD A;  4YKE A;  5EQV A;  2YVT A;  2NYL C;  2O8G A;  3HVQ A;  4J6O A;  1M63 A;  3H63 A;  5F3W A;  3QFN A;  3H68 A;  2KKN A;  3DSC A;  2Z1A A;  2BDX A;  3IVE A;  2P6B A;  2GJU A;  4Q7F A;  2WDD A;  3P71 C;  4LU9 A;  4O5G A;  4JA7 A;  4V0W A;  5GTU A;  4H2I A;  1SU1 A;  5C1V A;  4V0X A;  4TUG A;  2WDF A;  4FCX A;  2QFR A;  3IVD A;  5J28 A;  4V0V A;  2HY1 A;  3E7B A;  5B8I A;  3H64 A;  2DFJ A;  4DSY A;  4WWL A;  1T70 A;  1USH A;  4IYP C;  4H2F A;  1KBP A;  4IL1 A;  1XM7 A;  2HYP A;  4O43 A;  2BQ8 X;  3QG5 C;  3H67 A;  3RL4 A;  4MP0 A;  3H66 A;  3ICF A;  2CV9 A;  4G9J A;  4XPN A;  3EGH A;  1OI8 A;  3C5W C;  3QFM A;  2QJC A;  1Z2W A;  3H61 A;  1G5B A;  2O8A A;  1T71 A;  3KBP A;  4UT3 A;  1S3M A;  3ZTV A;  1S3L A;  2IE3 C;  4M0V A;  5JJT A;  4F0Z A;  1V73 A;  4I5L C;  5DNY A;  1W24 A;  3H62 B;  4OR9 A;  5HPE A;  2QFP A;  2JOG A;  1FJM A;  1OID A;  1S8E A;  5JPF A;  4ZVZ A;  3AUZ A;  4ORB A;  4KKZ A;  3FGA C;  4LTY A;  3RQZ A;  4UT2 A;  2WDE A;  4DHL A;  1NNW A;  3THN A;  1UTE A;  1XZW A;  3CK2 A;  3JYF A;  2R17 A;  2NYM C;  5JPE A;  3QFO A;  2WDC A; 
#chains in the Genus database with same CATH topology
 2Z72 A;  3K7W C;  2NXF A;  2IAE C;  4ZX2 A;  1QFC A;  3V4Y A;  2ZBM A;  3RL5 A;  3QFK A;  2AHD A;  4ORC A;  4H2G A;  5INB A;  4MOY A;  1HPU A;  4NZV A;  4I5N C;  4H2B A;  1HP1 A;  3EGG A;  1OIE A;  1IT6 A;  2DXN A;  1WAO 1;  1MF8 A;  1AUI A;  3RL3 A;  3N5U A;  3AV0 A;  2USH A;  2Q8U A;  4MOV A;  3TGH A;  1QHW A;  2A22 A;  2BCD A;  3FLO A;  4TUI A;  2HYO A;  4H1Y P;  3LL8 A;  4FBK A;  4O24 A;  1WAR A;  3IB8 A;  1U32 A;  4UWQ A;  3THO B;  3IB7 A;  3K7V C;  1HO5 A;  1TCO A;  3T1I A;  2YEQ A;  1Z2X A;  4LAC C;  4UT3 B;  3PSN A;  3E7A A;  1S3N A;  2NPP C;  4HD0 A;  1UF3 A;  1S70 A;  2ZOA A;  3ZU0 A;  3DW8 C;  1JK7 A;  1II7 A;  4KBP A;  2XMO A;  4B2O A;  4H1S A;  3PSO A;  3C9F A;  3E0J A;  5IOH A;  2Z06 A;  4O4K A;  1S95 A;  4JA9 A;  3GVE A;  2IE4 C;  4ORA A;  4FBQ A;  3H60 A;  3H69 A;  4DT2 A;  4FBW A;  3DSD A;  4YKE A;  5EQV A;  2YVT A;  2NYL C;  2O8G A;  3HVQ A;  2ZO9 B;  4J6O A;  1M63 A;  3H63 A;  5F3W A;  3QFN A;  3H68 A;  2KKN A;  3DSC A;  2Z1A A;  2BDX A;  3IVE A;  2P6B A;  2GJU A;  4Q7F A;  2WDD A;  3P71 C;  4LU9 A;  4O5G A;  4JA7 A;  4V0W A;  5GTU A;  4H2I A;  1SU1 A;  5C1V A;  3D03 A;  4V0X A;  4TUG A;  2WDF A;  4FCX A;  2QFR A;  3IVD A;  5J28 A;  4V0V A;  2HY1 A;  3E7B A;  5B8I A;  3H64 A;  2DFJ A;  4DSY A;  4WWL A;  1T70 A;  1USH A;  4IYP C;  4H2F A;  1KBP A;  4IL1 A;  1XM7 A;  2HYP A;  4O43 A;  2BQ8 X;  3QG5 C;  3H67 A;  3RL4 A;  4MP0 A;  3H66 A;  3ICF A;  2CV9 A;  4G9J A;  4XPN A;  3EGH A;  1OI8 A;  3C5W C;  3QFM A;  2QJC A;  1Z2W A;  3H61 A;  2DXL A;  1G5B A;  2O8A A;  1T71 A;  3KBP A;  4UT3 A;  1S3M A;  3ZTV A;  1S3L A;  2IE3 C;  4M0V A;  5JJT A;  4F0Z A;  1V73 A;  4I5L C;  5DNY A;  1W24 A;  3H62 B;  4OR9 A;  5HPE A;  2QFP A;  2JOG A;  1FJM A;  1OID A;  1S8E A;  5JPF A;  4ZVZ A;  3AUZ A;  4ORB A;  4KKZ A;  3FGA C;  4LTY A;  3RQZ A;  4UT2 A;  2WDE A;  4DHL A;  1NNW A;  3THN A;  1UTE A;  1XZW A;  3CK2 A;  3JYF A;  2R17 A;  2NYM C;  5JPE A;  3QFO A;  2WDC A; 
#chains in the Genus database with same CATH homology
 2Z72 A;  3K7W C;  2NXF A;  2IAE C;  4ZX2 A;  1QFC A;  3V4Y A;  2ZBM A;  3RL5 A;  3QFK A;  2AHD A;  4ORC A;  4H2G A;  5INB A;  4MOY A;  1HPU A;  4NZV A;  4I5N C;  4H2B A;  1HP1 A;  3EGG A;  1OIE A;  1IT6 A;  2DXN A;  1WAO 1;  1MF8 A;  1AUI A;  3RL3 A;  3N5U A;  3AV0 A;  2USH A;  2Q8U A;  4MOV A;  3TGH A;  1QHW A;  2A22 A;  2BCD A;  3FLO A;  4TUI A;  2HYO A;  4H1Y P;  3LL8 A;  4FBK A;  4O24 A;  1WAR A;  3IB8 A;  1U32 A;  4UWQ A;  3THO B;  3IB7 A;  3K7V C;  1HO5 A;  1TCO A;  3T1I A;  2YEQ A;  1Z2X A;  4LAC C;  4UT3 B;  3PSN A;  3E7A A;  1S3N A;  2NPP C;  4HD0 A;  1UF3 A;  1S70 A;  2ZOA A;  3ZU0 A;  3DW8 C;  1JK7 A;  1II7 A;  4KBP A;  2XMO A;  4B2O A;  4H1S A;  3PSO A;  3C9F A;  3E0J A;  5IOH A;  2Z06 A;  4O4K A;  1S95 A;  4JA9 A;  3GVE A;  2IE4 C;  4ORA A;  4FBQ A;  3H60 A;  3H69 A;  4DT2 A;  4FBW A;  3DSD A;  4YKE A;  5EQV A;  2YVT A;  2NYL C;  2O8G A;  3HVQ A;  2ZO9 B;  4J6O A;  1M63 A;  3H63 A;  5F3W A;  3QFN A;  3H68 A;  2KKN A;  3DSC A;  2Z1A A;  2BDX A;  3IVE A;  2P6B A;  2GJU A;  4Q7F A;  2WDD A;  3P71 C;  4LU9 A;  4O5G A;  4JA7 A;  4V0W A;  5GTU A;  4H2I A;  1SU1 A;  5C1V A;  3D03 A;  4V0X A;  4TUG A;  2WDF A;  4FCX A;  2QFR A;  3IVD A;  5J28 A;  4V0V A;  2HY1 A;  3E7B A;  5B8I A;  3H64 A;  2DFJ A;  4DSY A;  4WWL A;  1T70 A;  1USH A;  4IYP C;  4H2F A;  1KBP A;  4IL1 A;  1XM7 A;  2HYP A;  4O43 A;  2BQ8 X;  3QG5 C;  3H67 A;  3RL4 A;  4MP0 A;  3H66 A;  3ICF A;  2CV9 A;  4G9J A;  4XPN A;  3EGH A;  1OI8 A;  3C5W C;  3QFM A;  2QJC A;  1Z2W A;  3H61 A;  2DXL A;  1G5B A;  2O8A A;  1T71 A;  3KBP A;  4UT3 A;  1S3M A;  3ZTV A;  1S3L A;  2IE3 C;  4M0V A;  5JJT A;  4F0Z A;  1V73 A;  4I5L C;  5DNY A;  1W24 A;  3H62 B;  4OR9 A;  5HPE A;  2QFP A;  2JOG A;  1FJM A;  1OID A;  1S8E A;  5JPF A;  4ZVZ A;  3AUZ A;  4ORB A;  4KKZ A;  3FGA C;  4LTY A;  3RQZ A;  4UT2 A;  2WDE A;  4DHL A;  1NNW A;  3THN A;  1UTE A;  1XZW A;  3CK2 A;  3JYF A;  2R17 A;  2NYM C;  5JPE A;  3QFO A;  2WDC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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