3EGGA

Crystal structure of a complex between protein phosphatase 1 alpha (pp1) and the pp1 binding and pdz domains of spinophilin
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
294
structure length
294
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 112
structure length 294
sequence length 294
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3eggA00
3ZTVA 4NZVA 3C9FA 3QFMA 5B8IA 5JPFA 4TUGA 4UT2A 4I5NC 2KKNA 3V4YA 4LU9A 1S3MA 4FBKA 4OR9A 3H63A 4ORBA 1S95A 1HPUA 3JYFA 1WARA 3THOB 3RL4A 2IE3C 2Z72A 2BQ8X 4ZX2A 4DHLA 2O8GA 2QJCA 4MOYA 4DT2A 5C1VA 1HP1A 2NYLC 1Z2XA 2DFJA 3T1IA 3DSDA 2HY1A 3PSOA 4DSYA 5JPEA 3N5UA 1MF8A 2NPPC 4WWLA 3H64A 2NXFA 3C5WC 1HO5A 2GJUA 2IE4C 3QFKA 1NNWA 3H66A 1JK7A 3HVQA 3CK2A 3EGGA 4XPNA 2XMOA 1G5BA 4V0VA 2BDXA 3LL8A 1S3NA 5GTUA 1M63A 1TCOA 3QFNA 4H2FA 4UWQA 1KBPA 4TUIA 1U32A 4HD0A 2Q8UA 2O8AA 3FGAC 4FCXA 4MP0A 4UT3B 3ICFA 1T71A 2Z06A 3KBPA 4FBQA 1SU1A 3AUZA 4O24A 4H1YP 4ZVZA 5IOHA 1XZWA 3DW8C 4M0VA 4KKZA 4Q7FA 2AHDA 4UT3A 1WAO1 1T70A 3QG5C 5HPEA 3RL5A 4JA9A 3H60A 4H2BA 1FJMA 4FBWA 1S8EA 1II7A 3E7AA 3K7VC 2JOGA 2WDFA 4V0XA 1AUIA 3GVEA 3H67A 3H62B 3QFOA 4ORAA 5F3WA 4H2IA 1XM7A 2IAEC 2HYOA 4LTYA 3IB8A 4ORCA 1W24A 4J6OA 2CV9A 3H69A 3P71C 4O5GA 2USHA 3ZU0A 2P6BA 2R17A 3RQZA 4KBPA 1QHWA 5EQVA 3AV0A 4O4KA 1UTEA 1UF3A 2A22A 2ZBMA 2BCDA 1USHA 5J28A 4H1SA 4B2OA 4LACC 4YKEA 5DNYA 1S3LA 4IL1A 2QFPA 3DSCA 2HYPA 4O43A 1OIDA 1S70A 1OIEA 4JA7A 2NYMC 4MOVA 3TGHA 3E7BA 2YVTA 5INBA 4IYPC 4H2GA 2WDDA 1V73A 3IB7A 4G9JA 2Z1AA 3H61A 1OI8A 3PSNA 2WDEA 5JJTA 3H68A 4F0ZA 1Z2WA 4V0WA 3THNA 3EGHA 3IVDA 3RL3A 3K7WC 1QFCA 4I5LC 3IVEA 1IT6A 2QFRA 2WDCA
chains in the Genus database with same CATH superfamily
3ZTVA 4NZVA 3C9FA 3QFMA 5B8IA 5JPFA 4TUGA 4UT2A 4I5NC 2KKNA 3V4YA 4LU9A 1S3MA 4FBKA 4OR9A 3H63A 4ORBA 1S95A 1HPUA 3JYFA 1WARA 3THOB 3RL4A 2IE3C 2Z72A 2BQ8X 4ZX2A 4DHLA 2O8GA 2QJCA 4MOYA 4DT2A 5C1VA 1HP1A 2NYLC 1Z2XA 2DFJA 3T1IA 2DXNA 2HY1A 3PSOA 4DSYA 5JPEA 3N5UA 1MF8A 3DSDA 2NPPC 4WWLA 3H64A 2NXFA 3C5WC 1HO5A 2GJUA 2IE4C 3QFKA 1NNWA 3H66A 1JK7A 3HVQA 3CK2A 3EGGA 4XPNA 2XMOA 1G5BA 2YEQA 4V0VA 2BDXA 3LL8A 1S3NA 5GTUA 1M63A 1TCOA 3QFNA 4H2FA 4UWQA 1KBPA 4TUIA 1U32A 4HD0A 2Q8UA 2O8AA 3FGAC 4FCXA 4MP0A 4UT3B 3ICFA 1T71A 2Z06A 3KBPA 4FBQA 1SU1A 3AUZA 4O24A 4H1YP 4ZVZA 2ZOAA 5IOHA 1XZWA 3DW8C 4M0VA 4KKZA 4Q7FA 2AHDA 4UT3A 1WAO1 1T70A 3QG5C 5HPEA 3RL5A 4JA9A 3H60A 4H2BA 1FJMA 4FBWA 1S8EA 1II7A 3E7AA 3K7VC 2JOGA 2WDFA 4V0XA 1AUIA 3GVEA 3H67A 3H62B 3QFOA 4ORAA 5F3WA 4H2IA 1XM7A 2DXLA 2IAEC 2HYOA 4LTYA 3IB8A 4ORCA 2ZO9B 1W24A 4J6OA 2CV9A 3H69A 3P71C 4O5GA 2USHA 3ZU0A 2P6BA 2R17A 3RQZA 4KBPA 1QHWA 5EQVA 3AV0A 4O4KA 1UTEA 1UF3A 2A22A 2ZBMA 3FLOA 2BCDA 1USHA 5J28A 4H1SA 4B2OA 4LACC 4YKEA 5DNYA 1S3LA 4IL1A 2QFPA 3DSCA 2HYPA 4O43A 1OIDA 1S70A 1OIEA 3E0JA 4JA7A 2NYMC 4MOVA 3TGHA 3E7BA 2YVTA 3D03A 5INBA 4IYPC 4H2GA 2WDDA 1V73A 3IB7A 4G9JA 2Z1AA 3H61A 1OI8A 3PSNA 2WDEA 5JJTA 3H68A 4F0ZA 1Z2WA 4V0WA 3THNA 3EGHA 3IVDA 3RL3A 3K7WC 1QFCA 4I5LC 3IVEA 1IT6A 2QFRA 2WDCA
chains in the Genus database with same CATH topology
3ZTVA 4NZVA 3C9FA 3QFMA 5B8IA 5JPFA 4TUGA 4UT2A 4I5NC 2KKNA 3V4YA 4LU9A 1S3MA 4FBKA 4OR9A 3H63A 4ORBA 1S95A 1HPUA 3JYFA 1WARA 3THOB 3RL4A 2IE3C 2Z72A 2BQ8X 4ZX2A 4DHLA 2O8GA 2QJCA 4MOYA 4DT2A 5C1VA 1HP1A 2NYLC 1Z2XA 2DFJA 3T1IA 2DXNA 2HY1A 3PSOA 4DSYA 5JPEA 3N5UA 1MF8A 3DSDA 2NPPC 4WWLA 3H64A 2NXFA 3C5WC 1HO5A 2GJUA 2IE4C 3QFKA 1NNWA 3H66A 1JK7A 3HVQA 3CK2A 3EGGA 4XPNA 2XMOA 1G5BA 2YEQA 4V0VA 2BDXA 3LL8A 1S3NA 5GTUA 1M63A 1TCOA 3QFNA 4H2FA 4UWQA 1KBPA 4TUIA 1U32A 4HD0A 2Q8UA 2O8AA 3FGAC 4FCXA 4MP0A 4UT3B 3ICFA 1T71A 2Z06A 3KBPA 4FBQA 1SU1A 3AUZA 4O24A 4H1YP 4ZVZA 2ZOAA 5IOHA 1XZWA 3DW8C 4M0VA 4KKZA 4Q7FA 2AHDA 4UT3A 1WAO1 1T70A 3QG5C 5HPEA 3RL5A 4JA9A 3H60A 4H2BA 1FJMA 4FBWA 1S8EA 1II7A 3E7AA 3K7VC 2JOGA 2WDFA 4V0XA 1AUIA 3GVEA 3H67A 3H62B 3QFOA 4ORAA 5F3WA 4H2IA 1XM7A 2DXLA 2IAEC 2HYOA 4LTYA 3IB8A 4ORCA 2ZO9B 1W24A 4J6OA 2CV9A 3H69A 3P71C 4O5GA 2USHA 3ZU0A 2P6BA 2R17A 3RQZA 4KBPA 1QHWA 5EQVA 3AV0A 4O4KA 1UTEA 1UF3A 2A22A 2ZBMA 3FLOA 2BCDA 1USHA 5J28A 4H1SA 4B2OA 4LACC 4YKEA 5DNYA 1S3LA 4IL1A 2QFPA 3DSCA 2HYPA 4O43A 1OIDA 1S70A 1OIEA 3E0JA 4JA7A 2NYMC 4MOVA 3TGHA 3E7BA 2YVTA 3D03A 5INBA 4IYPC 4H2GA 2WDDA 1V73A 3IB7A 4G9JA 2Z1AA 3H61A 1OI8A 3PSNA 2WDEA 5JJTA 3H68A 4F0ZA 1Z2WA 4V0WA 3THNA 3EGHA 3IVDA 3RL3A 3K7WC 1QFCA 4I5LC 3IVEA 1IT6A 2QFRA 2WDCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZTV A;  4NZV A;  3C9F A;  3QFM A;  5B8I A;  5JPF A;  4TUG A;  4UT2 A;  4I5N C;  2KKN A;  3V4Y A;  4LU9 A;  1S3M A;  4FBK A;  4OR9 A;  3H63 A;  4ORB A;  1S95 A;  1HPU A;  3JYF A;  1WAR A;  3THO B;  3RL4 A;  2IE3 C;  2Z72 A;  2BQ8 X;  4ZX2 A;  4DHL A;  2O8G A;  2QJC A;  4MOY A;  4DT2 A;  5C1V A;  1HP1 A;  2NYL C;  1Z2X A;  2DFJ A;  3T1I A;  3DSD A;  2HY1 A;  3PSO A;  4DSY A;  5JPE A;  3N5U A;  1MF8 A;  2NPP C;  4WWL A;  3H64 A;  2NXF A;  3C5W C;  1HO5 A;  2GJU A;  2IE4 C;  3QFK A;  1NNW A;  3H66 A;  1JK7 A;  3HVQ A;  3CK2 A;  3EGG A;  4XPN A;  2XMO A;  1G5B A;  4V0V A;  2BDX A;  3LL8 A;  1S3N A;  5GTU A;  1M63 A;  1TCO A;  3QFN A;  4H2F A;  4UWQ A;  1KBP A;  4TUI A;  1U32 A;  4HD0 A;  2Q8U A;  2O8A A;  3FGA C;  4FCX A;  4MP0 A;  4UT3 B;  3ICF A;  1T71 A;  2Z06 A;  3KBP A;  4FBQ A;  1SU1 A;  3AUZ A;  4O24 A;  4H1Y P;  4ZVZ A;  5IOH A;  1XZW A;  3DW8 C;  4M0V A;  4KKZ A;  4Q7F A;  2AHD A;  4UT3 A;  1WAO 1;  1T70 A;  3QG5 C;  5HPE A;  3RL5 A;  4JA9 A;  3H60 A;  4H2B A;  1FJM A;  4FBW A;  1S8E A;  1II7 A;  3E7A A;  3K7V C;  2JOG A;  2WDF A;  4V0X A;  1AUI A;  3GVE A;  3H67 A;  3H62 B;  3QFO A;  4ORA A;  5F3W A;  4H2I A;  1XM7 A;  2IAE C;  2HYO A;  4LTY A;  3IB8 A;  4ORC A;  1W24 A;  4J6O A;  2CV9 A;  3H69 A;  3P71 C;  4O5G A;  2USH A;  3ZU0 A;  2P6B A;  2R17 A;  3RQZ A;  4KBP A;  1QHW A;  5EQV A;  3AV0 A;  4O4K A;  1UTE A;  1UF3 A;  2A22 A;  2ZBM A;  2BCD A;  1USH A;  5J28 A;  4H1S A;  4B2O A;  4LAC C;  4YKE A;  5DNY A;  1S3L A;  4IL1 A;  2QFP A;  3DSC A;  2HYP A;  4O43 A;  1OID A;  1S70 A;  1OIE A;  4JA7 A;  2NYM C;  4MOV A;  3TGH A;  3E7B A;  2YVT A;  5INB A;  4IYP C;  4H2G A;  2WDD A;  1V73 A;  3IB7 A;  4G9J A;  2Z1A A;  3H61 A;  1OI8 A;  3PSN A;  2WDE A;  5JJT A;  3H68 A;  4F0Z A;  1Z2W A;  4V0W A;  3THN A;  3EGH A;  3IVD A;  3RL3 A;  3K7W C;  1QFC A;  4I5L C;  3IVE A;  1IT6 A;  2QFR A;  2WDC A; 
#chains in the Genus database with same CATH topology
 3ZTV A;  4NZV A;  3C9F A;  3QFM A;  5B8I A;  5JPF A;  4TUG A;  4UT2 A;  4I5N C;  2KKN A;  3V4Y A;  4LU9 A;  1S3M A;  4FBK A;  4OR9 A;  3H63 A;  4ORB A;  1S95 A;  1HPU A;  3JYF A;  1WAR A;  3THO B;  3RL4 A;  2IE3 C;  2Z72 A;  2BQ8 X;  4ZX2 A;  4DHL A;  2O8G A;  2QJC A;  4MOY A;  4DT2 A;  5C1V A;  1HP1 A;  2NYL C;  1Z2X A;  2DFJ A;  3T1I A;  2DXN A;  2HY1 A;  3PSO A;  4DSY A;  5JPE A;  3N5U A;  1MF8 A;  3DSD A;  2NPP C;  4WWL A;  3H64 A;  2NXF A;  3C5W C;  1HO5 A;  2GJU A;  2IE4 C;  3QFK A;  1NNW A;  3H66 A;  1JK7 A;  3HVQ A;  3CK2 A;  3EGG A;  4XPN A;  2XMO A;  1G5B A;  2YEQ A;  4V0V A;  2BDX A;  3LL8 A;  1S3N A;  5GTU A;  1M63 A;  1TCO A;  3QFN A;  4H2F A;  4UWQ A;  1KBP A;  4TUI A;  1U32 A;  4HD0 A;  2Q8U A;  2O8A A;  3FGA C;  4FCX A;  4MP0 A;  4UT3 B;  3ICF A;  1T71 A;  2Z06 A;  3KBP A;  4FBQ A;  1SU1 A;  3AUZ A;  4O24 A;  4H1Y P;  4ZVZ A;  2ZOA A;  5IOH A;  1XZW A;  3DW8 C;  4M0V A;  4KKZ A;  4Q7F A;  2AHD A;  4UT3 A;  1WAO 1;  1T70 A;  3QG5 C;  5HPE A;  3RL5 A;  4JA9 A;  3H60 A;  4H2B A;  1FJM A;  4FBW A;  1S8E A;  1II7 A;  3E7A A;  3K7V C;  2JOG A;  2WDF A;  4V0X A;  1AUI A;  3GVE A;  3H67 A;  3H62 B;  3QFO A;  4ORA A;  5F3W A;  4H2I A;  1XM7 A;  2DXL A;  2IAE C;  2HYO A;  4LTY A;  3IB8 A;  4ORC A;  2ZO9 B;  1W24 A;  4J6O A;  2CV9 A;  3H69 A;  3P71 C;  4O5G A;  2USH A;  3ZU0 A;  2P6B A;  2R17 A;  3RQZ A;  4KBP A;  1QHW A;  5EQV A;  3AV0 A;  4O4K A;  1UTE A;  1UF3 A;  2A22 A;  2ZBM A;  3FLO A;  2BCD A;  1USH A;  5J28 A;  4H1S A;  4B2O A;  4LAC C;  4YKE A;  5DNY A;  1S3L A;  4IL1 A;  2QFP A;  3DSC A;  2HYP A;  4O43 A;  1OID A;  1S70 A;  1OIE A;  3E0J A;  4JA7 A;  2NYM C;  4MOV A;  3TGH A;  3E7B A;  2YVT A;  3D03 A;  5INB A;  4IYP C;  4H2G A;  2WDD A;  1V73 A;  3IB7 A;  4G9J A;  2Z1A A;  3H61 A;  1OI8 A;  3PSN A;  2WDE A;  5JJT A;  3H68 A;  4F0Z A;  1Z2W A;  4V0W A;  3THN A;  3EGH A;  3IVD A;  3RL3 A;  3K7W C;  1QFC A;  4I5L C;  3IVE A;  1IT6 A;  2QFR A;  2WDC A; 
#chains in the Genus database with same CATH homology
 3ZTV A;  4NZV A;  3C9F A;  3QFM A;  5B8I A;  5JPF A;  4TUG A;  4UT2 A;  4I5N C;  2KKN A;  3V4Y A;  4LU9 A;  1S3M A;  4FBK A;  4OR9 A;  3H63 A;  4ORB A;  1S95 A;  1HPU A;  3JYF A;  1WAR A;  3THO B;  3RL4 A;  2IE3 C;  2Z72 A;  2BQ8 X;  4ZX2 A;  4DHL A;  2O8G A;  2QJC A;  4MOY A;  4DT2 A;  5C1V A;  1HP1 A;  2NYL C;  1Z2X A;  2DFJ A;  3T1I A;  2DXN A;  2HY1 A;  3PSO A;  4DSY A;  5JPE A;  3N5U A;  1MF8 A;  3DSD A;  2NPP C;  4WWL A;  3H64 A;  2NXF A;  3C5W C;  1HO5 A;  2GJU A;  2IE4 C;  3QFK A;  1NNW A;  3H66 A;  1JK7 A;  3HVQ A;  3CK2 A;  3EGG A;  4XPN A;  2XMO A;  1G5B A;  2YEQ A;  4V0V A;  2BDX A;  3LL8 A;  1S3N A;  5GTU A;  1M63 A;  1TCO A;  3QFN A;  4H2F A;  4UWQ A;  1KBP A;  4TUI A;  1U32 A;  4HD0 A;  2Q8U A;  2O8A A;  3FGA C;  4FCX A;  4MP0 A;  4UT3 B;  3ICF A;  1T71 A;  2Z06 A;  3KBP A;  4FBQ A;  1SU1 A;  3AUZ A;  4O24 A;  4H1Y P;  4ZVZ A;  2ZOA A;  5IOH A;  1XZW A;  3DW8 C;  4M0V A;  4KKZ A;  4Q7F A;  2AHD A;  4UT3 A;  1WAO 1;  1T70 A;  3QG5 C;  5HPE A;  3RL5 A;  4JA9 A;  3H60 A;  4H2B A;  1FJM A;  4FBW A;  1S8E A;  1II7 A;  3E7A A;  3K7V C;  2JOG A;  2WDF A;  4V0X A;  1AUI A;  3GVE A;  3H67 A;  3H62 B;  3QFO A;  4ORA A;  5F3W A;  4H2I A;  1XM7 A;  2DXL A;  2IAE C;  2HYO A;  4LTY A;  3IB8 A;  4ORC A;  2ZO9 B;  1W24 A;  4J6O A;  2CV9 A;  3H69 A;  3P71 C;  4O5G A;  2USH A;  3ZU0 A;  2P6B A;  2R17 A;  3RQZ A;  4KBP A;  1QHW A;  5EQV A;  3AV0 A;  4O4K A;  1UTE A;  1UF3 A;  2A22 A;  2ZBM A;  3FLO A;  2BCD A;  1USH A;  5J28 A;  4H1S A;  4B2O A;  4LAC C;  4YKE A;  5DNY A;  1S3L A;  4IL1 A;  2QFP A;  3DSC A;  2HYP A;  4O43 A;  1OID A;  1S70 A;  1OIE A;  3E0J A;  4JA7 A;  2NYM C;  4MOV A;  3TGH A;  3E7B A;  2YVT A;  3D03 A;  5INB A;  4IYP C;  4H2G A;  2WDD A;  1V73 A;  3IB7 A;  4G9J A;  2Z1A A;  3H61 A;  1OI8 A;  3PSN A;  2WDE A;  5JJT A;  3H68 A;  4F0Z A;  1Z2W A;  4V0W A;  3THN A;  3EGH A;  3IVD A;  3RL3 A;  3K7W C;  1QFC A;  4I5L C;  3IVE A;  1IT6 A;  2QFR A;  2WDC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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