3EGGA

Crystal structure of a complex between protein phosphatase 1 alpha (pp1) and the pp1 binding and pdz domains of spinophilin
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
294
structure length
294
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 112
structure length 294
sequence length 294
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3eggA00
3QG5C 1QFCA 4HD0A 1S3LA 4UWQA 3THNA 4H2GA 4O24A 1IT6A 3H61A 1NNWA 3AV0A 2WDFA 1OI8A 3H68A 2O8AA 1T71A 1S70A 3H67A 2YVTA 4F0ZA 1V73A 2R17A 1FJMA 2XMOA 3P71C 5J28A 4MP0A 2QFPA 2HYPA 2HYOA 3AUZA 3V4YA 2CV9A 3EGGA 4O5GA 5GTUA 1OIDA 2QJCA 1KBPA 3PSOA 1S3MA 1W24A 4ORAA 4FBQA 2BQ8X 3IVDA 3QFOA 3THOB 2O8GA 1OIEA 2P6BA 3N5UA 3T1IA 4H2FA 1G5BA 1XM7A 1II7A 3RL3A 4B2OA 1XZWA 2HY1A 4O4KA 3QFNA 4KKZA 5B8IA 2DFJA 1MF8A 4MOVA 2Z1AA 3ZTVA 4ORBA 1M63A 1Z2WA 2NYMC 3RQZA 2GJUA 1U32A 4DSYA 2BCDA 3EGHA 4V0WA 1AUIA 4WWLA 3QFMA 4I5NC 4TUIA 1SU1A 2NYLC 2QFRA 4H2BA 5F3WA 3DW8C 2BDXA 3IB7A 3LL8A 4LTYA 1UTEA 4IL1A 4ZVZA 1QHWA 3H62B 4I5LC 5EQVA 1WARA 2WDDA 4JA7A 3RL4A 4LACC 3K7WC 4JA9A 4FCXA 3H69A 4UT3A 1HP1A 2Z06A 5C1VA 3GVEA 1JK7A 5JPEA 3PSNA 3IVEA 1UF3A 5JJTA 4Q7FA 4ORCA 5JPFA 3DSCA 3H66A 4H2IA 4J6OA 4MOYA 2NPPC 2Q8UA 2WDEA 4YKEA 1HPUA 4UT2A 3CK2A 3RL5A 1TCOA 3KBPA 1USHA 3JYFA 3IB8A 1S8EA 4DT2A 3H63A 4IYPC 2USHA 5IOHA 2NXFA 1HO5A 4TUGA 1Z2XA 1T70A 3ZU0A 2WDCA 3HVQA 3QFKA 2IE4C 2Z72A 3FGAC 4DHLA 1S3NA 3E7AA 4OR9A 4V0XA 4M0VA 4V0VA 4FBWA 2ZBMA 1S95A 2IAEC 5HPEA 3E7BA 4G9JA 3H64A 1WAO1 3K7VC 4XPNA 3C9FA 4NZVA 4UT3B 5INBA 4ZX2A 2JOGA 3DSDA 3TGHA 2IE3C 5DNYA 4LU9A 3C5WC 2AHDA 4H1SA 4KBPA 4O43A 2A22A 2KKNA 3ICFA 3H60A 4H1YP 4FBKA
chains in the Genus database with same CATH superfamily
3QG5C 1QFCA 4HD0A 1S3LA 4UWQA 3THNA 4H2GA 4O24A 1IT6A 3H61A 1NNWA 3AV0A 2WDFA 1OI8A 3H68A 2O8AA 1T71A 1S70A 3H67A 2YVTA 4F0ZA 1V73A 2R17A 1FJMA 2XMOA 3P71C 5J28A 4MP0A 2QFPA 2HYPA 2HYOA 3AUZA 3V4YA 2CV9A 3EGGA 4O5GA 5GTUA 1OIDA 2QJCA 2YEQA 1KBPA 3PSOA 1S3MA 1W24A 4ORAA 4FBQA 2BQ8X 3IVDA 3QFOA 3THOB 2O8GA 1OIEA 2P6BA 3N5UA 3T1IA 4H2FA 1G5BA 1XM7A 1II7A 3RL3A 4B2OA 1XZWA 2HY1A 4O4KA 3QFNA 4KKZA 5B8IA 2DFJA 1MF8A 4MOVA 2Z1AA 3ZTVA 4ORBA 1M63A 1Z2WA 2NYMC 3RQZA 2DXLA 1U32A 2GJUA 4DSYA 2BCDA 3EGHA 4V0WA 1AUIA 4WWLA 3QFMA 4I5NC 3D03A 4TUIA 1SU1A 2NYLC 2QFRA 4H2BA 5F3WA 3DW8C 2BDXA 3IB7A 3LL8A 4LTYA 1UTEA 4IL1A 4ZVZA 1QHWA 3H62B 4I5LC 5EQVA 1WARA 2WDDA 4JA7A 3RL4A 4LACC 3K7WC 4JA9A 4FCXA 3H69A 4UT3A 1HP1A 2Z06A 5C1VA 3GVEA 1JK7A 5JPEA 3PSNA 3IVEA 1UF3A 2ZOAA 5JJTA 4Q7FA 4ORCA 5JPFA 3DSCA 3H66A 4H2IA 4J6OA 4MOYA 2NPPC 2Q8UA 2WDEA 3FLOA 1HPUA 4YKEA 4UT2A 3CK2A 3RL5A 1TCOA 3KBPA 1USHA 3JYFA 3IB8A 1S8EA 4DT2A 3H63A 4IYPC 2USHA 5IOHA 2NXFA 1HO5A 4TUGA 1Z2XA 1T70A 3ZU0A 2WDCA 3HVQA 3QFKA 2IE4C 2Z72A 3FGAC 4DHLA 1S3NA 3E7AA 4OR9A 4V0XA 4M0VA 4V0VA 2ZO9B 4FBWA 2ZBMA 1S95A 2IAEC 5HPEA 3E7BA 4G9JA 3H64A 1WAO1 3K7VC 4XPNA 3C9FA 4NZVA 4UT3B 5INBA 4ZX2A 2JOGA 3DSDA 3TGHA 2DXNA 2IE3C 5DNYA 4LU9A 3C5WC 2AHDA 4H1SA 4KBPA 4O43A 2A22A 2KKNA 3ICFA 3H60A 4H1YP 3E0JA 4FBKA
chains in the Genus database with same CATH topology
3QG5C 1QFCA 4HD0A 1S3LA 4UWQA 3THNA 4H2GA 4O24A 1IT6A 3H61A 1NNWA 3AV0A 2WDFA 1OI8A 3H68A 2O8AA 1T71A 1S70A 3H67A 2YVTA 4F0ZA 1V73A 2R17A 1FJMA 2XMOA 3P71C 5J28A 4MP0A 2QFPA 2HYPA 2HYOA 3AUZA 3V4YA 2CV9A 3EGGA 4O5GA 5GTUA 1OIDA 2QJCA 2YEQA 1KBPA 3PSOA 1S3MA 1W24A 4ORAA 4FBQA 2BQ8X 3IVDA 3QFOA 3THOB 2O8GA 1OIEA 2P6BA 3N5UA 3T1IA 4H2FA 1G5BA 1XM7A 1II7A 3RL3A 4B2OA 1XZWA 2HY1A 4O4KA 3QFNA 4KKZA 5B8IA 2DFJA 1MF8A 4MOVA 2Z1AA 3ZTVA 4ORBA 1M63A 1Z2WA 2NYMC 3RQZA 2DXLA 1U32A 2GJUA 4DSYA 2BCDA 3EGHA 4V0WA 1AUIA 4WWLA 3QFMA 4I5NC 3D03A 4TUIA 1SU1A 2NYLC 2QFRA 4H2BA 5F3WA 3DW8C 2BDXA 3IB7A 3LL8A 4LTYA 1UTEA 4IL1A 4ZVZA 1QHWA 3H62B 4I5LC 5EQVA 1WARA 2WDDA 4JA7A 3RL4A 4LACC 3K7WC 4JA9A 4FCXA 3H69A 4UT3A 1HP1A 2Z06A 5C1VA 3GVEA 1JK7A 5JPEA 3PSNA 3IVEA 1UF3A 2ZOAA 5JJTA 4Q7FA 4ORCA 5JPFA 3DSCA 3H66A 4H2IA 4J6OA 4MOYA 2NPPC 2Q8UA 2WDEA 3FLOA 1HPUA 4YKEA 4UT2A 3CK2A 3RL5A 1TCOA 3KBPA 1USHA 3JYFA 3IB8A 1S8EA 4DT2A 3H63A 4IYPC 2USHA 5IOHA 2NXFA 1HO5A 4TUGA 1Z2XA 1T70A 3ZU0A 2WDCA 3HVQA 3QFKA 2IE4C 2Z72A 3FGAC 4DHLA 1S3NA 3E7AA 4OR9A 4V0XA 4M0VA 4V0VA 2ZO9B 4FBWA 2ZBMA 1S95A 2IAEC 5HPEA 3E7BA 4G9JA 3H64A 1WAO1 3K7VC 4XPNA 3C9FA 4NZVA 4UT3B 5INBA 4ZX2A 2JOGA 3DSDA 3TGHA 2DXNA 2IE3C 5DNYA 4LU9A 3C5WC 2AHDA 4H1SA 4KBPA 4O43A 2A22A 2KKNA 3ICFA 3H60A 4H1YP 3E0JA 4FBKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QG5 C;  1QFC A;  4HD0 A;  1S3L A;  4UWQ A;  3THN A;  4H2G A;  4O24 A;  1IT6 A;  3H61 A;  1NNW A;  3AV0 A;  2WDF A;  1OI8 A;  3H68 A;  2O8A A;  1T71 A;  1S70 A;  3H67 A;  2YVT A;  4F0Z A;  1V73 A;  2R17 A;  1FJM A;  2XMO A;  3P71 C;  5J28 A;  4MP0 A;  2QFP A;  2HYP A;  2HYO A;  3AUZ A;  3V4Y A;  2CV9 A;  3EGG A;  4O5G A;  5GTU A;  1OID A;  2QJC A;  1KBP A;  3PSO A;  1S3M A;  1W24 A;  4ORA A;  4FBQ A;  2BQ8 X;  3IVD A;  3QFO A;  3THO B;  2O8G A;  1OIE A;  2P6B A;  3N5U A;  3T1I A;  4H2F A;  1G5B A;  1XM7 A;  1II7 A;  3RL3 A;  4B2O A;  1XZW A;  2HY1 A;  4O4K A;  3QFN A;  4KKZ A;  5B8I A;  2DFJ A;  1MF8 A;  4MOV A;  2Z1A A;  3ZTV A;  4ORB A;  1M63 A;  1Z2W A;  2NYM C;  3RQZ A;  2GJU A;  1U32 A;  4DSY A;  2BCD A;  3EGH A;  4V0W A;  1AUI A;  4WWL A;  3QFM A;  4I5N C;  4TUI A;  1SU1 A;  2NYL C;  2QFR A;  4H2B A;  5F3W A;  3DW8 C;  2BDX A;  3IB7 A;  3LL8 A;  4LTY A;  1UTE A;  4IL1 A;  4ZVZ A;  1QHW A;  3H62 B;  4I5L C;  5EQV A;  1WAR A;  2WDD A;  4JA7 A;  3RL4 A;  4LAC C;  3K7W C;  4JA9 A;  4FCX A;  3H69 A;  4UT3 A;  1HP1 A;  2Z06 A;  5C1V A;  3GVE A;  1JK7 A;  5JPE A;  3PSN A;  3IVE A;  1UF3 A;  5JJT A;  4Q7F A;  4ORC A;  5JPF A;  3DSC A;  3H66 A;  4H2I A;  4J6O A;  4MOY A;  2NPP C;  2Q8U A;  2WDE A;  4YKE A;  1HPU A;  4UT2 A;  3CK2 A;  3RL5 A;  1TCO A;  3KBP A;  1USH A;  3JYF A;  3IB8 A;  1S8E A;  4DT2 A;  3H63 A;  4IYP C;  2USH A;  5IOH A;  2NXF A;  1HO5 A;  4TUG A;  1Z2X A;  1T70 A;  3ZU0 A;  2WDC A;  3HVQ A;  3QFK A;  2IE4 C;  2Z72 A;  3FGA C;  4DHL A;  1S3N A;  3E7A A;  4OR9 A;  4V0X A;  4M0V A;  4V0V A;  4FBW A;  2ZBM A;  1S95 A;  2IAE C;  5HPE A;  3E7B A;  4G9J A;  3H64 A;  1WAO 1;  3K7V C;  4XPN A;  3C9F A;  4NZV A;  4UT3 B;  5INB A;  4ZX2 A;  2JOG A;  3DSD A;  3TGH A;  2IE3 C;  5DNY A;  4LU9 A;  3C5W C;  2AHD A;  4H1S A;  4KBP A;  4O43 A;  2A22 A;  2KKN A;  3ICF A;  3H60 A;  4H1Y P;  4FBK A; 
#chains in the Genus database with same CATH topology
 3QG5 C;  1QFC A;  4HD0 A;  1S3L A;  4UWQ A;  3THN A;  4H2G A;  4O24 A;  1IT6 A;  3H61 A;  1NNW A;  3AV0 A;  2WDF A;  1OI8 A;  3H68 A;  2O8A A;  1T71 A;  1S70 A;  3H67 A;  2YVT A;  4F0Z A;  1V73 A;  2R17 A;  1FJM A;  2XMO A;  3P71 C;  5J28 A;  4MP0 A;  2QFP A;  2HYP A;  2HYO A;  3AUZ A;  3V4Y A;  2CV9 A;  3EGG A;  4O5G A;  5GTU A;  1OID A;  2QJC A;  2YEQ A;  1KBP A;  3PSO A;  1S3M A;  1W24 A;  4ORA A;  4FBQ A;  2BQ8 X;  3IVD A;  3QFO A;  3THO B;  2O8G A;  1OIE A;  2P6B A;  3N5U A;  3T1I A;  4H2F A;  1G5B A;  1XM7 A;  1II7 A;  3RL3 A;  4B2O A;  1XZW A;  2HY1 A;  4O4K A;  3QFN A;  4KKZ A;  5B8I A;  2DFJ A;  1MF8 A;  4MOV A;  2Z1A A;  3ZTV A;  4ORB A;  1M63 A;  1Z2W A;  2NYM C;  3RQZ A;  2DXL A;  1U32 A;  2GJU A;  4DSY A;  2BCD A;  3EGH A;  4V0W A;  1AUI A;  4WWL A;  3QFM A;  4I5N C;  3D03 A;  4TUI A;  1SU1 A;  2NYL C;  2QFR A;  4H2B A;  5F3W A;  3DW8 C;  2BDX A;  3IB7 A;  3LL8 A;  4LTY A;  1UTE A;  4IL1 A;  4ZVZ A;  1QHW A;  3H62 B;  4I5L C;  5EQV A;  1WAR A;  2WDD A;  4JA7 A;  3RL4 A;  4LAC C;  3K7W C;  4JA9 A;  4FCX A;  3H69 A;  4UT3 A;  1HP1 A;  2Z06 A;  5C1V A;  3GVE A;  1JK7 A;  5JPE A;  3PSN A;  3IVE A;  1UF3 A;  2ZOA A;  5JJT A;  4Q7F A;  4ORC A;  5JPF A;  3DSC A;  3H66 A;  4H2I A;  4J6O A;  4MOY A;  2NPP C;  2Q8U A;  2WDE A;  3FLO A;  1HPU A;  4YKE A;  4UT2 A;  3CK2 A;  3RL5 A;  1TCO A;  3KBP A;  1USH A;  3JYF A;  3IB8 A;  1S8E A;  4DT2 A;  3H63 A;  4IYP C;  2USH A;  5IOH A;  2NXF A;  1HO5 A;  4TUG A;  1Z2X A;  1T70 A;  3ZU0 A;  2WDC A;  3HVQ A;  3QFK A;  2IE4 C;  2Z72 A;  3FGA C;  4DHL A;  1S3N A;  3E7A A;  4OR9 A;  4V0X A;  4M0V A;  4V0V A;  2ZO9 B;  4FBW A;  2ZBM A;  1S95 A;  2IAE C;  5HPE A;  3E7B A;  4G9J A;  3H64 A;  1WAO 1;  3K7V C;  4XPN A;  3C9F A;  4NZV A;  4UT3 B;  5INB A;  4ZX2 A;  2JOG A;  3DSD A;  3TGH A;  2DXN A;  2IE3 C;  5DNY A;  4LU9 A;  3C5W C;  2AHD A;  4H1S A;  4KBP A;  4O43 A;  2A22 A;  2KKN A;  3ICF A;  3H60 A;  4H1Y P;  3E0J A;  4FBK A; 
#chains in the Genus database with same CATH homology
 3QG5 C;  1QFC A;  4HD0 A;  1S3L A;  4UWQ A;  3THN A;  4H2G A;  4O24 A;  1IT6 A;  3H61 A;  1NNW A;  3AV0 A;  2WDF A;  1OI8 A;  3H68 A;  2O8A A;  1T71 A;  1S70 A;  3H67 A;  2YVT A;  4F0Z A;  1V73 A;  2R17 A;  1FJM A;  2XMO A;  3P71 C;  5J28 A;  4MP0 A;  2QFP A;  2HYP A;  2HYO A;  3AUZ A;  3V4Y A;  2CV9 A;  3EGG A;  4O5G A;  5GTU A;  1OID A;  2QJC A;  2YEQ A;  1KBP A;  3PSO A;  1S3M A;  1W24 A;  4ORA A;  4FBQ A;  2BQ8 X;  3IVD A;  3QFO A;  3THO B;  2O8G A;  1OIE A;  2P6B A;  3N5U A;  3T1I A;  4H2F A;  1G5B A;  1XM7 A;  1II7 A;  3RL3 A;  4B2O A;  1XZW A;  2HY1 A;  4O4K A;  3QFN A;  4KKZ A;  5B8I A;  2DFJ A;  1MF8 A;  4MOV A;  2Z1A A;  3ZTV A;  4ORB A;  1M63 A;  1Z2W A;  2NYM C;  3RQZ A;  2DXL A;  1U32 A;  2GJU A;  4DSY A;  2BCD A;  3EGH A;  4V0W A;  1AUI A;  4WWL A;  3QFM A;  4I5N C;  3D03 A;  4TUI A;  1SU1 A;  2NYL C;  2QFR A;  4H2B A;  5F3W A;  3DW8 C;  2BDX A;  3IB7 A;  3LL8 A;  4LTY A;  1UTE A;  4IL1 A;  4ZVZ A;  1QHW A;  3H62 B;  4I5L C;  5EQV A;  1WAR A;  2WDD A;  4JA7 A;  3RL4 A;  4LAC C;  3K7W C;  4JA9 A;  4FCX A;  3H69 A;  4UT3 A;  1HP1 A;  2Z06 A;  5C1V A;  3GVE A;  1JK7 A;  5JPE A;  3PSN A;  3IVE A;  1UF3 A;  2ZOA A;  5JJT A;  4Q7F A;  4ORC A;  5JPF A;  3DSC A;  3H66 A;  4H2I A;  4J6O A;  4MOY A;  2NPP C;  2Q8U A;  2WDE A;  3FLO A;  1HPU A;  4YKE A;  4UT2 A;  3CK2 A;  3RL5 A;  1TCO A;  3KBP A;  1USH A;  3JYF A;  3IB8 A;  1S8E A;  4DT2 A;  3H63 A;  4IYP C;  2USH A;  5IOH A;  2NXF A;  1HO5 A;  4TUG A;  1Z2X A;  1T70 A;  3ZU0 A;  2WDC A;  3HVQ A;  3QFK A;  2IE4 C;  2Z72 A;  3FGA C;  4DHL A;  1S3N A;  3E7A A;  4OR9 A;  4V0X A;  4M0V A;  4V0V A;  2ZO9 B;  4FBW A;  2ZBM A;  1S95 A;  2IAE C;  5HPE A;  3E7B A;  4G9J A;  3H64 A;  1WAO 1;  3K7V C;  4XPN A;  3C9F A;  4NZV A;  4UT3 B;  5INB A;  4ZX2 A;  2JOG A;  3DSD A;  3TGH A;  2DXN A;  2IE3 C;  5DNY A;  4LU9 A;  3C5W C;  2AHD A;  4H1S A;  4KBP A;  4O43 A;  2A22 A;  2KKN A;  3ICF A;  3H60 A;  4H1Y P;  3E0J A;  4FBK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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