3H63A

Catalytic domain of human serine/threonine phosphatase 5 (pp5c) with two mn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
315
structure length
315
Chain Sequence
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 5
molecule tags Hydrolase
source organism Homo sapiens
total genus 116
structure length 315
sequence length 315
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3h63A00
4JA7A 5JPEA 4B2OA 5EQVA 1T71A 4TUIA 4IYPC 4M0VA 2USHA 4NZVA 4H1SA 2QFPA 4KBPA 3H64A 1QHWA 1HO5A 2QJCA 3QFNA 3T1IA 4UT2A 1QFCA 2NYMC 4UT3B 3PSNA 4ORCA 1G5BA 3DW8C 1WAO1 4O43A 3FGAC 4DT2A 4TUGA 2Z1AA 4MOVA 4ZVZA 3IB8A 2P6BA 1V73A 3DSCA 5JPFA 4O24A 4DHLA 2YVTA 4H2IA 4YKEA 4OR9A 1OI8A 3N5UA 3IVEA 3C9FA 1UF3A 3ZTVA 4JA9A 3RL5A 2KKNA 4HD0A 1S3LA 4LTYA 5B8IA 3QG5C 5DNYA 1NNWA 2HYPA 4ORAA 4G9JA 2O8AA 5C1VA 4WWLA 2XMOA 1OIDA 2GJUA 4DSYA 3QFMA 3DSDA 1Z2XA 3RL4A 4LU9A 1IT6A 1AUIA 3PSOA 3AV0A 4MP0A 4O4KA 2WDDA 4V0VA 1U32A 3QFOA 3H61A 1FJMA 1MF8A 3H66A 4FBKA 5INBA 5HPEA 3H60A 1WARA 2CV9A 3ZU0A 3THOB 3AUZA 3TGHA 3LL8A 3V4YA 1KBPA 1USHA 3H69A 4H2GA 4J6OA 4UT3A 1S3MA 5J28A 2ZBMA 2R17A 4ORBA 2WDEA 3C5WC 4Q7FA 1HP1A 1TCOA 2NXFA 2AHDA 4UWQA 3H63A 1UTEA 4I5NC 3K7VC 2BQ8X 2HYOA 2NPPC 3HVQA 4H2FA 4V0XA 1XM7A 2WDCA 1W24A 4O5GA 4F0ZA 2JOGA 4FCXA 1Z2WA 3THNA 3IB7A 3KBPA 4IL1A 2IE3C 4KKZA 4ZX2A 4LACC 4MOYA 3IVDA 1HPUA 4H1YP 2Z06A 2A22A 2WDFA 5JJTA 3RQZA 1T70A 3E7BA 4H2BA 3P71C 3E7AA 3H68A 2O8GA 3RL3A 5F3WA 3EGGA 5IOHA 2NYLC 3H67A 2Q8UA 3JYFA 1SU1A 2IAEC 3K7WC 2IE4C 1XZWA 3EGHA 2HY1A 1JK7A 1S70A 4I5LC 1S8EA 2BCDA 1S3NA 5GTUA 2DFJA 1OIEA 4FBWA 2Z72A 3H62B 4V0WA 4FBQA 3GVEA 1II7A 1M63A 1S95A 2BDXA 3CK2A 3ICFA 4XPNA 2QFRA 3QFKA
chains in the Genus database with same CATH superfamily
4JA7A 2ZO9B 5JPEA 4B2OA 5EQVA 1T71A 4TUIA 4IYPC 4M0VA 2USHA 4NZVA 4H1SA 2QFPA 4KBPA 3H64A 1QHWA 1HO5A 2QJCA 3QFNA 3T1IA 4UT2A 1QFCA 2NYMC 4UT3B 3PSNA 4ORCA 1G5BA 3DW8C 1WAO1 4O43A 3FGAC 4DT2A 4TUGA 2Z1AA 4MOVA 4ZVZA 3IB8A 2P6BA 1V73A 3DSCA 5JPFA 4O24A 4DHLA 2YVTA 4H2IA 4YKEA 4OR9A 1OI8A 3N5UA 3IVEA 3C9FA 1UF3A 3ZTVA 4JA9A 3RL5A 2KKNA 4HD0A 1S3LA 4LTYA 5B8IA 3QG5C 5DNYA 1NNWA 2HYPA 4ORAA 4G9JA 2O8AA 5C1VA 4WWLA 2XMOA 1OIDA 2GJUA 4DSYA 3QFMA 3DSDA 1Z2XA 3RL4A 4LU9A 1IT6A 1AUIA 3PSOA 3AV0A 4MP0A 4O4KA 2WDDA 4V0VA 1U32A 3QFOA 3H61A 1FJMA 1MF8A 3H66A 4FBKA 5INBA 5HPEA 3H60A 1WARA 2CV9A 3ZU0A 3THOB 3AUZA 2YEQA 3LL8A 3TGHA 3V4YA 1KBPA 1USHA 3H69A 4H2GA 4J6OA 4UT3A 1S3MA 5J28A 2ZBMA 2R17A 4ORBA 2WDEA 3C5WC 4Q7FA 1HP1A 1TCOA 2NXFA 2AHDA 4UWQA 2ZOAA 3H63A 1UTEA 4I5NC 3K7VC 2BQ8X 2HYOA 2NPPC 3HVQA 4H2FA 4V0XA 1XM7A 2WDCA 1W24A 4O5GA 4F0ZA 2JOGA 4FCXA 1Z2WA 3THNA 3IB7A 3KBPA 4IL1A 2IE3C 4KKZA 4ZX2A 4LACC 4MOYA 3IVDA 1HPUA 4H1YP 2Z06A 2A22A 2WDFA 5JJTA 3RQZA 1T70A 3E7BA 4H2BA 3P71C 3E7AA 3H68A 2O8GA 3RL3A 5F3WA 3EGGA 5IOHA 2NYLC 3H67A 2Q8UA 3JYFA 1SU1A 2IAEC 3K7WC 2IE4C 1XZWA 3EGHA 2HY1A 1JK7A 1S70A 4I5LC 1S8EA 2BCDA 3E0JA 1S3NA 5GTUA 2DFJA 1OIEA 2DXLA 4FBWA 2Z72A 3H62B 4V0WA 4FBQA 3GVEA 1II7A 1M63A 1S95A 2DXNA 3D03A 2BDXA 3CK2A 3FLOA 3ICFA 4XPNA 2QFRA 3QFKA
chains in the Genus database with same CATH topology
4JA7A 2ZO9B 5JPEA 4B2OA 5EQVA 1T71A 4TUIA 4IYPC 4M0VA 2USHA 4NZVA 4H1SA 2QFPA 4KBPA 3H64A 1QHWA 1HO5A 2QJCA 3QFNA 3T1IA 4UT2A 1QFCA 2NYMC 4UT3B 3PSNA 4ORCA 1G5BA 3DW8C 1WAO1 4O43A 3FGAC 4DT2A 4TUGA 2Z1AA 4MOVA 4ZVZA 3IB8A 2P6BA 1V73A 3DSCA 5JPFA 4O24A 4DHLA 2YVTA 4H2IA 4YKEA 4OR9A 1OI8A 3N5UA 3IVEA 3C9FA 1UF3A 3ZTVA 4JA9A 3RL5A 2KKNA 4HD0A 1S3LA 4LTYA 5B8IA 3QG5C 5DNYA 1NNWA 2HYPA 4ORAA 4G9JA 2O8AA 5C1VA 4WWLA 2XMOA 1OIDA 2GJUA 4DSYA 3QFMA 3DSDA 1Z2XA 3RL4A 4LU9A 1IT6A 1AUIA 3PSOA 3AV0A 4MP0A 4O4KA 2WDDA 4V0VA 1U32A 3QFOA 3H61A 1FJMA 1MF8A 3H66A 4FBKA 5INBA 5HPEA 3H60A 1WARA 2CV9A 3ZU0A 3THOB 3AUZA 2YEQA 3LL8A 3TGHA 3V4YA 1KBPA 1USHA 3H69A 4H2GA 4J6OA 4UT3A 1S3MA 5J28A 2ZBMA 2R17A 4ORBA 2WDEA 3C5WC 4Q7FA 1HP1A 1TCOA 2NXFA 2AHDA 4UWQA 2ZOAA 3H63A 1UTEA 4I5NC 3K7VC 2BQ8X 2HYOA 2NPPC 3HVQA 4H2FA 4V0XA 1XM7A 2WDCA 1W24A 4O5GA 4F0ZA 2JOGA 4FCXA 1Z2WA 3THNA 3IB7A 3KBPA 4IL1A 2IE3C 4KKZA 4ZX2A 4LACC 4MOYA 3IVDA 1HPUA 4H1YP 2Z06A 2A22A 2WDFA 5JJTA 3RQZA 1T70A 3E7BA 4H2BA 3P71C 3E7AA 3H68A 2O8GA 3RL3A 5F3WA 3EGGA 5IOHA 2NYLC 3H67A 2Q8UA 3JYFA 1SU1A 2IAEC 3K7WC 2IE4C 1XZWA 3EGHA 2HY1A 1JK7A 1S70A 4I5LC 1S8EA 2BCDA 3E0JA 1S3NA 5GTUA 2DFJA 1OIEA 2DXLA 4FBWA 2Z72A 3H62B 4V0WA 4FBQA 3GVEA 1II7A 1M63A 1S95A 2DXNA 3D03A 2BDXA 3CK2A 3FLOA 3ICFA 4XPNA 2QFRA 3QFKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JA7 A;  5JPE A;  4B2O A;  5EQV A;  1T71 A;  4TUI A;  4IYP C;  4M0V A;  2USH A;  4NZV A;  4H1S A;  2QFP A;  4KBP A;  3H64 A;  1QHW A;  1HO5 A;  2QJC A;  3QFN A;  3T1I A;  4UT2 A;  1QFC A;  2NYM C;  4UT3 B;  3PSN A;  4ORC A;  1G5B A;  3DW8 C;  1WAO 1;  4O43 A;  3FGA C;  4DT2 A;  4TUG A;  2Z1A A;  4MOV A;  4ZVZ A;  3IB8 A;  2P6B A;  1V73 A;  3DSC A;  5JPF A;  4O24 A;  4DHL A;  2YVT A;  4H2I A;  4YKE A;  4OR9 A;  1OI8 A;  3N5U A;  3IVE A;  3C9F A;  1UF3 A;  3ZTV A;  4JA9 A;  3RL5 A;  2KKN A;  4HD0 A;  1S3L A;  4LTY A;  5B8I A;  3QG5 C;  5DNY A;  1NNW A;  2HYP A;  4ORA A;  4G9J A;  2O8A A;  5C1V A;  4WWL A;  2XMO A;  1OID A;  2GJU A;  4DSY A;  3QFM A;  3DSD A;  1Z2X A;  3RL4 A;  4LU9 A;  1IT6 A;  1AUI A;  3PSO A;  3AV0 A;  4MP0 A;  4O4K A;  2WDD A;  4V0V A;  1U32 A;  3QFO A;  3H61 A;  1FJM A;  1MF8 A;  3H66 A;  4FBK A;  5INB A;  5HPE A;  3H60 A;  1WAR A;  2CV9 A;  3ZU0 A;  3THO B;  3AUZ A;  3TGH A;  3LL8 A;  3V4Y A;  1KBP A;  1USH A;  3H69 A;  4H2G A;  4J6O A;  4UT3 A;  1S3M A;  5J28 A;  2ZBM A;  2R17 A;  4ORB A;  2WDE A;  3C5W C;  4Q7F A;  1HP1 A;  1TCO A;  2NXF A;  2AHD A;  4UWQ A;  3H63 A;  1UTE A;  4I5N C;  3K7V C;  2BQ8 X;  2HYO A;  2NPP C;  3HVQ A;  4H2F A;  4V0X A;  1XM7 A;  2WDC A;  1W24 A;  4O5G A;  4F0Z A;  2JOG A;  4FCX A;  1Z2W A;  3THN A;  3IB7 A;  3KBP A;  4IL1 A;  2IE3 C;  4KKZ A;  4ZX2 A;  4LAC C;  4MOY A;  3IVD A;  1HPU A;  4H1Y P;  2Z06 A;  2A22 A;  2WDF A;  5JJT A;  3RQZ A;  1T70 A;  3E7B A;  4H2B A;  3P71 C;  3E7A A;  3H68 A;  2O8G A;  3RL3 A;  5F3W A;  3EGG A;  5IOH A;  2NYL C;  3H67 A;  2Q8U A;  3JYF A;  1SU1 A;  2IAE C;  3K7W C;  2IE4 C;  1XZW A;  3EGH A;  2HY1 A;  1JK7 A;  1S70 A;  4I5L C;  1S8E A;  2BCD A;  1S3N A;  5GTU A;  2DFJ A;  1OIE A;  4FBW A;  2Z72 A;  3H62 B;  4V0W A;  4FBQ A;  3GVE A;  1II7 A;  1M63 A;  1S95 A;  2BDX A;  3CK2 A;  3ICF A;  4XPN A;  2QFR A;  3QFK A; 
#chains in the Genus database with same CATH topology
 4JA7 A;  2ZO9 B;  5JPE A;  4B2O A;  5EQV A;  1T71 A;  4TUI A;  4IYP C;  4M0V A;  2USH A;  4NZV A;  4H1S A;  2QFP A;  4KBP A;  3H64 A;  1QHW A;  1HO5 A;  2QJC A;  3QFN A;  3T1I A;  4UT2 A;  1QFC A;  2NYM C;  4UT3 B;  3PSN A;  4ORC A;  1G5B A;  3DW8 C;  1WAO 1;  4O43 A;  3FGA C;  4DT2 A;  4TUG A;  2Z1A A;  4MOV A;  4ZVZ A;  3IB8 A;  2P6B A;  1V73 A;  3DSC A;  5JPF A;  4O24 A;  4DHL A;  2YVT A;  4H2I A;  4YKE A;  4OR9 A;  1OI8 A;  3N5U A;  3IVE A;  3C9F A;  1UF3 A;  3ZTV A;  4JA9 A;  3RL5 A;  2KKN A;  4HD0 A;  1S3L A;  4LTY A;  5B8I A;  3QG5 C;  5DNY A;  1NNW A;  2HYP A;  4ORA A;  4G9J A;  2O8A A;  5C1V A;  4WWL A;  2XMO A;  1OID A;  2GJU A;  4DSY A;  3QFM A;  3DSD A;  1Z2X A;  3RL4 A;  4LU9 A;  1IT6 A;  1AUI A;  3PSO A;  3AV0 A;  4MP0 A;  4O4K A;  2WDD A;  4V0V A;  1U32 A;  3QFO A;  3H61 A;  1FJM A;  1MF8 A;  3H66 A;  4FBK A;  5INB A;  5HPE A;  3H60 A;  1WAR A;  2CV9 A;  3ZU0 A;  3THO B;  3AUZ A;  2YEQ A;  3LL8 A;  3TGH A;  3V4Y A;  1KBP A;  1USH A;  3H69 A;  4H2G A;  4J6O A;  4UT3 A;  1S3M A;  5J28 A;  2ZBM A;  2R17 A;  4ORB A;  2WDE A;  3C5W C;  4Q7F A;  1HP1 A;  1TCO A;  2NXF A;  2AHD A;  4UWQ A;  2ZOA A;  3H63 A;  1UTE A;  4I5N C;  3K7V C;  2BQ8 X;  2HYO A;  2NPP C;  3HVQ A;  4H2F A;  4V0X A;  1XM7 A;  2WDC A;  1W24 A;  4O5G A;  4F0Z A;  2JOG A;  4FCX A;  1Z2W A;  3THN A;  3IB7 A;  3KBP A;  4IL1 A;  2IE3 C;  4KKZ A;  4ZX2 A;  4LAC C;  4MOY A;  3IVD A;  1HPU A;  4H1Y P;  2Z06 A;  2A22 A;  2WDF A;  5JJT A;  3RQZ A;  1T70 A;  3E7B A;  4H2B A;  3P71 C;  3E7A A;  3H68 A;  2O8G A;  3RL3 A;  5F3W A;  3EGG A;  5IOH A;  2NYL C;  3H67 A;  2Q8U A;  3JYF A;  1SU1 A;  2IAE C;  3K7W C;  2IE4 C;  1XZW A;  3EGH A;  2HY1 A;  1JK7 A;  1S70 A;  4I5L C;  1S8E A;  2BCD A;  3E0J A;  1S3N A;  5GTU A;  2DFJ A;  1OIE A;  2DXL A;  4FBW A;  2Z72 A;  3H62 B;  4V0W A;  4FBQ A;  3GVE A;  1II7 A;  1M63 A;  1S95 A;  2DXN A;  3D03 A;  2BDX A;  3CK2 A;  3FLO A;  3ICF A;  4XPN A;  2QFR A;  3QFK A; 
#chains in the Genus database with same CATH homology
 4JA7 A;  2ZO9 B;  5JPE A;  4B2O A;  5EQV A;  1T71 A;  4TUI A;  4IYP C;  4M0V A;  2USH A;  4NZV A;  4H1S A;  2QFP A;  4KBP A;  3H64 A;  1QHW A;  1HO5 A;  2QJC A;  3QFN A;  3T1I A;  4UT2 A;  1QFC A;  2NYM C;  4UT3 B;  3PSN A;  4ORC A;  1G5B A;  3DW8 C;  1WAO 1;  4O43 A;  3FGA C;  4DT2 A;  4TUG A;  2Z1A A;  4MOV A;  4ZVZ A;  3IB8 A;  2P6B A;  1V73 A;  3DSC A;  5JPF A;  4O24 A;  4DHL A;  2YVT A;  4H2I A;  4YKE A;  4OR9 A;  1OI8 A;  3N5U A;  3IVE A;  3C9F A;  1UF3 A;  3ZTV A;  4JA9 A;  3RL5 A;  2KKN A;  4HD0 A;  1S3L A;  4LTY A;  5B8I A;  3QG5 C;  5DNY A;  1NNW A;  2HYP A;  4ORA A;  4G9J A;  2O8A A;  5C1V A;  4WWL A;  2XMO A;  1OID A;  2GJU A;  4DSY A;  3QFM A;  3DSD A;  1Z2X A;  3RL4 A;  4LU9 A;  1IT6 A;  1AUI A;  3PSO A;  3AV0 A;  4MP0 A;  4O4K A;  2WDD A;  4V0V A;  1U32 A;  3QFO A;  3H61 A;  1FJM A;  1MF8 A;  3H66 A;  4FBK A;  5INB A;  5HPE A;  3H60 A;  1WAR A;  2CV9 A;  3ZU0 A;  3THO B;  3AUZ A;  2YEQ A;  3LL8 A;  3TGH A;  3V4Y A;  1KBP A;  1USH A;  3H69 A;  4H2G A;  4J6O A;  4UT3 A;  1S3M A;  5J28 A;  2ZBM A;  2R17 A;  4ORB A;  2WDE A;  3C5W C;  4Q7F A;  1HP1 A;  1TCO A;  2NXF A;  2AHD A;  4UWQ A;  2ZOA A;  3H63 A;  1UTE A;  4I5N C;  3K7V C;  2BQ8 X;  2HYO A;  2NPP C;  3HVQ A;  4H2F A;  4V0X A;  1XM7 A;  2WDC A;  1W24 A;  4O5G A;  4F0Z A;  2JOG A;  4FCX A;  1Z2W A;  3THN A;  3IB7 A;  3KBP A;  4IL1 A;  2IE3 C;  4KKZ A;  4ZX2 A;  4LAC C;  4MOY A;  3IVD A;  1HPU A;  4H1Y P;  2Z06 A;  2A22 A;  2WDF A;  5JJT A;  3RQZ A;  1T70 A;  3E7B A;  4H2B A;  3P71 C;  3E7A A;  3H68 A;  2O8G A;  3RL3 A;  5F3W A;  3EGG A;  5IOH A;  2NYL C;  3H67 A;  2Q8U A;  3JYF A;  1SU1 A;  2IAE C;  3K7W C;  2IE4 C;  1XZW A;  3EGH A;  2HY1 A;  1JK7 A;  1S70 A;  4I5L C;  1S8E A;  2BCD A;  3E0J A;  1S3N A;  5GTU A;  2DFJ A;  1OIE A;  2DXL A;  4FBW A;  2Z72 A;  3H62 B;  4V0W A;  4FBQ A;  3GVE A;  1II7 A;  1M63 A;  1S95 A;  2DXN A;  3D03 A;  2BDX A;  3CK2 A;  3FLO A;  3ICF A;  4XPN A;  2QFR A;  3QFK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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