3H64A

Catalytic domain of human serine/threonine phosphatase 5 (pp5c) with two mn2+ atoms complexed with endothall
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
309
structure length
309
Chain Sequence
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 5
total genus 108
structure length 309
sequence length 309
chains with identical sequence D
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3h64A00
1M63A 1OIDA 1TCOA 4J6OA 1S3NA 2USHA 3ICFA 1HO5A 4LTYA 5DNYA 3IB8A 1OI8A 3P71C 1KBPA 3H64A 1WAO1 4H2GA 3IB7A 2WDFA 1II7A 2BQ8X 5JJTA 4UT2A 2QFPA 1UTEA 3EGGA 4KBPA 4UWQA 3PSOA 4H2FA 5JPFA 3PSNA 1MF8A 2NYMC 4DSYA 4LACC 2Q8UA 1T70A 3THNA 2XMOA 3KBPA 4O5GA 1NNWA 2JOGA 5HPEA 1JK7A 4JA9A 1Z2WA 4IL1A 3T1IA 2P6BA 2QJCA 2ZBMA 1HP1A 4H1YP 2R17A 3QFNA 4O43A 2AHDA 4DHLA 3E7BA 1S95A 3H66A 4FBWA 3RL4A 1QFCA 1USHA 3H62B 4KKZA 4IYPC 2NPPC 2O8AA 4G9JA 1HPUA 1S3LA 4V0WA 4JA7A 1FJMA 4MOYA 3HVQA 1XM7A 4UT3B 3C5WC 1XZWA 4O4KA 4Q7FA 2IE4C 3ZTVA 4V0VA 5IOHA 1S70A 1V73A 4YKEA 4H2BA 1AUIA 3ZU0A 4UT3A 5INBA 4TUIA 5F3WA 3H69A 1Z2XA 1IT6A 4HD0A 2Z1AA 3K7VC 4MOVA 5J28A 2QFRA 1QHWA 3IVDA 2GJUA 3DW8C 1T71A 3AV0A 3H60A 2HYPA 4ORAA 3QFKA 3RL5A 2WDCA 1W24A 1UF3A 4I5LC 4M0VA 4O24A 3H68A 2WDDA 3E7AA 3C9FA 2WDEA 3V4YA 2A22A 3IVEA 4ORBA 3CK2A 3DSDA 2HYOA 3RQZA 1U32A 2DFJA 3H61A 3DSCA 2BCDA 3GVEA 3H63A 2IE3C 4NZVA 4ZX2A 4ORCA 3LL8A 5GTUA 4ZVZA 2KKNA 5C1VA 4B2OA 5B8IA 2HY1A 3FGAC 3QFMA 3RL3A 2YVTA 3QG5C 4OR9A 1G5BA 1OIEA 3K7WC 4H2IA 2CV9A 2NYLC 3QFOA 4H1SA 1S3MA 4LU9A 1WARA 4FBQA 4I5NC 5JPEA 4FCXA 2NXFA 4FBKA 4XPNA 3TGHA 5EQVA 3AUZA 3EGHA 4MP0A 4TUGA 4WWLA 3JYFA 4V0XA 4F0ZA 3THOB 2BDXA 1S8EA 1SU1A 2Z06A 3N5UA 4DT2A 2O8GA 3H67A 2Z72A 2IAEC
chains in the Genus database with same CATH superfamily
1M63A 1OIDA 3E0JA 1TCOA 4J6OA 1S3NA 2USHA 3ICFA 1HO5A 4LTYA 5DNYA 3IB8A 1OI8A 3P71C 1KBPA 3H64A 1WAO1 4H2GA 2DXLA 3IB7A 2WDFA 1II7A 2BQ8X 5JJTA 4UT2A 2QFPA 1UTEA 3EGGA 4KBPA 4UWQA 3PSOA 4H2FA 5JPFA 3PSNA 1MF8A 2NYMC 4DSYA 4LACC 2Q8UA 1T70A 3THNA 2XMOA 3KBPA 4O5GA 1NNWA 2JOGA 5HPEA 1JK7A 4JA9A 1Z2WA 4IL1A 3T1IA 2P6BA 2QJCA 2ZBMA 1HP1A 4H1YP 2R17A 3QFNA 4O43A 2AHDA 4DHLA 3E7BA 1S95A 3H66A 4FBWA 3RL4A 1QFCA 1USHA 3H62B 4KKZA 4IYPC 2NPPC 2O8AA 4G9JA 1HPUA 1S3LA 4V0WA 4JA7A 1FJMA 4MOYA 3HVQA 1XM7A 4UT3B 3C5WC 1XZWA 4O4KA 4Q7FA 2IE4C 3ZTVA 4V0VA 5IOHA 1S70A 1V73A 4YKEA 4H2BA 1AUIA 3ZU0A 4UT3A 5INBA 4TUIA 5F3WA 3H69A 1Z2XA 1IT6A 4HD0A 2Z1AA 3K7VC 4MOVA 5J28A 2QFRA 1QHWA 3IVDA 2GJUA 3DW8C 1T71A 2ZO9B 3AV0A 3H60A 2HYPA 4ORAA 3QFKA 3RL5A 2WDCA 2YEQA 1W24A 1UF3A 4I5LC 4M0VA 4O24A 3H68A 2WDDA 3E7AA 3C9FA 2WDEA 3V4YA 2A22A 3IVEA 4ORBA 3CK2A 3DSDA 2HYOA 3RQZA 1U32A 2DFJA 3H61A 3DSCA 2BCDA 3GVEA 3H63A 2IE3C 4NZVA 4ZX2A 4ORCA 3LL8A 5GTUA 2DXNA 4ZVZA 2KKNA 5C1VA 4B2OA 5B8IA 2HY1A 3FGAC 3QFMA 3RL3A 2YVTA 3QG5C 4OR9A 1G5BA 1OIEA 3K7WC 4H2IA 2CV9A 2NYLC 3QFOA 4H1SA 1S3MA 4LU9A 1WARA 4FBQA 3D03A 4I5NC 5JPEA 2ZOAA 4FCXA 2NXFA 4FBKA 4XPNA 3TGHA 5EQVA 3AUZA 3EGHA 4MP0A 4TUGA 4WWLA 3JYFA 4V0XA 4F0ZA 3THOB 2BDXA 1S8EA 1SU1A 2Z06A 3N5UA 4DT2A 2O8GA 3H67A 3FLOA 2Z72A 2IAEC
chains in the Genus database with same CATH topology
1M63A 1OIDA 3E0JA 1TCOA 4J6OA 1S3NA 2USHA 3ICFA 1HO5A 4LTYA 5DNYA 3IB8A 1OI8A 3P71C 1KBPA 3H64A 1WAO1 4H2GA 2DXLA 3IB7A 2WDFA 1II7A 2BQ8X 5JJTA 4UT2A 2QFPA 1UTEA 3EGGA 4KBPA 4UWQA 3PSOA 4H2FA 5JPFA 3PSNA 1MF8A 2NYMC 4DSYA 4LACC 2Q8UA 1T70A 3THNA 2XMOA 3KBPA 4O5GA 1NNWA 2JOGA 5HPEA 1JK7A 4JA9A 1Z2WA 4IL1A 3T1IA 2P6BA 2QJCA 2ZBMA 1HP1A 4H1YP 2R17A 3QFNA 4O43A 2AHDA 4DHLA 3E7BA 1S95A 3H66A 4FBWA 3RL4A 1QFCA 1USHA 3H62B 4KKZA 4IYPC 2NPPC 2O8AA 4G9JA 1HPUA 1S3LA 4V0WA 4JA7A 1FJMA 4MOYA 3HVQA 1XM7A 4UT3B 3C5WC 1XZWA 4O4KA 4Q7FA 2IE4C 3ZTVA 4V0VA 5IOHA 1S70A 1V73A 4YKEA 4H2BA 1AUIA 3ZU0A 4UT3A 5INBA 4TUIA 5F3WA 3H69A 1Z2XA 1IT6A 4HD0A 2Z1AA 3K7VC 4MOVA 5J28A 2QFRA 1QHWA 3IVDA 2GJUA 3DW8C 1T71A 2ZO9B 3AV0A 3H60A 2HYPA 4ORAA 3QFKA 3RL5A 2WDCA 2YEQA 1W24A 1UF3A 4I5LC 4M0VA 4O24A 3H68A 2WDDA 3E7AA 3C9FA 2WDEA 3V4YA 2A22A 3IVEA 4ORBA 3CK2A 3DSDA 2HYOA 3RQZA 1U32A 2DFJA 3H61A 3DSCA 2BCDA 3GVEA 3H63A 2IE3C 4NZVA 4ZX2A 4ORCA 3LL8A 5GTUA 2DXNA 4ZVZA 2KKNA 5C1VA 4B2OA 5B8IA 2HY1A 3FGAC 3QFMA 3RL3A 2YVTA 3QG5C 4OR9A 1G5BA 1OIEA 3K7WC 4H2IA 2CV9A 2NYLC 3QFOA 4H1SA 1S3MA 4LU9A 1WARA 4FBQA 3D03A 4I5NC 5JPEA 2ZOAA 4FCXA 2NXFA 4FBKA 4XPNA 3TGHA 5EQVA 3AUZA 3EGHA 4MP0A 4TUGA 4WWLA 3JYFA 4V0XA 4F0ZA 3THOB 2BDXA 1S8EA 1SU1A 2Z06A 3N5UA 4DT2A 2O8GA 3H67A 3FLOA 2Z72A 2IAEC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M63 A;  1OID A;  1TCO A;  4J6O A;  1S3N A;  2USH A;  3ICF A;  1HO5 A;  4LTY A;  5DNY A;  3IB8 A;  1OI8 A;  3P71 C;  1KBP A;  3H64 A;  1WAO 1;  4H2G A;  3IB7 A;  2WDF A;  1II7 A;  2BQ8 X;  5JJT A;  4UT2 A;  2QFP A;  1UTE A;  3EGG A;  4KBP A;  4UWQ A;  3PSO A;  4H2F A;  5JPF A;  3PSN A;  1MF8 A;  2NYM C;  4DSY A;  4LAC C;  2Q8U A;  1T70 A;  3THN A;  2XMO A;  3KBP A;  4O5G A;  1NNW A;  2JOG A;  5HPE A;  1JK7 A;  4JA9 A;  1Z2W A;  4IL1 A;  3T1I A;  2P6B A;  2QJC A;  2ZBM A;  1HP1 A;  4H1Y P;  2R17 A;  3QFN A;  4O43 A;  2AHD A;  4DHL A;  3E7B A;  1S95 A;  3H66 A;  4FBW A;  3RL4 A;  1QFC A;  1USH A;  3H62 B;  4KKZ A;  4IYP C;  2NPP C;  2O8A A;  4G9J A;  1HPU A;  1S3L A;  4V0W A;  4JA7 A;  1FJM A;  4MOY A;  3HVQ A;  1XM7 A;  4UT3 B;  3C5W C;  1XZW A;  4O4K A;  4Q7F A;  2IE4 C;  3ZTV A;  4V0V A;  5IOH A;  1S70 A;  1V73 A;  4YKE A;  4H2B A;  1AUI A;  3ZU0 A;  4UT3 A;  5INB A;  4TUI A;  5F3W A;  3H69 A;  1Z2X A;  1IT6 A;  4HD0 A;  2Z1A A;  3K7V C;  4MOV A;  5J28 A;  2QFR A;  1QHW A;  3IVD A;  2GJU A;  3DW8 C;  1T71 A;  3AV0 A;  3H60 A;  2HYP A;  4ORA A;  3QFK A;  3RL5 A;  2WDC A;  1W24 A;  1UF3 A;  4I5L C;  4M0V A;  4O24 A;  3H68 A;  2WDD A;  3E7A A;  3C9F A;  2WDE A;  3V4Y A;  2A22 A;  3IVE A;  4ORB A;  3CK2 A;  3DSD A;  2HYO A;  3RQZ A;  1U32 A;  2DFJ A;  3H61 A;  3DSC A;  2BCD A;  3GVE A;  3H63 A;  2IE3 C;  4NZV A;  4ZX2 A;  4ORC A;  3LL8 A;  5GTU A;  4ZVZ A;  2KKN A;  5C1V A;  4B2O A;  5B8I A;  2HY1 A;  3FGA C;  3QFM A;  3RL3 A;  2YVT A;  3QG5 C;  4OR9 A;  1G5B A;  1OIE A;  3K7W C;  4H2I A;  2CV9 A;  2NYL C;  3QFO A;  4H1S A;  1S3M A;  4LU9 A;  1WAR A;  4FBQ A;  4I5N C;  5JPE A;  4FCX A;  2NXF A;  4FBK A;  4XPN A;  3TGH A;  5EQV A;  3AUZ A;  3EGH A;  4MP0 A;  4TUG A;  4WWL A;  3JYF A;  4V0X A;  4F0Z A;  3THO B;  2BDX A;  1S8E A;  1SU1 A;  2Z06 A;  3N5U A;  4DT2 A;  2O8G A;  3H67 A;  2Z72 A;  2IAE C; 
#chains in the Genus database with same CATH topology
 1M63 A;  1OID A;  3E0J A;  1TCO A;  4J6O A;  1S3N A;  2USH A;  3ICF A;  1HO5 A;  4LTY A;  5DNY A;  3IB8 A;  1OI8 A;  3P71 C;  1KBP A;  3H64 A;  1WAO 1;  4H2G A;  2DXL A;  3IB7 A;  2WDF A;  1II7 A;  2BQ8 X;  5JJT A;  4UT2 A;  2QFP A;  1UTE A;  3EGG A;  4KBP A;  4UWQ A;  3PSO A;  4H2F A;  5JPF A;  3PSN A;  1MF8 A;  2NYM C;  4DSY A;  4LAC C;  2Q8U A;  1T70 A;  3THN A;  2XMO A;  3KBP A;  4O5G A;  1NNW A;  2JOG A;  5HPE A;  1JK7 A;  4JA9 A;  1Z2W A;  4IL1 A;  3T1I A;  2P6B A;  2QJC A;  2ZBM A;  1HP1 A;  4H1Y P;  2R17 A;  3QFN A;  4O43 A;  2AHD A;  4DHL A;  3E7B A;  1S95 A;  3H66 A;  4FBW A;  3RL4 A;  1QFC A;  1USH A;  3H62 B;  4KKZ A;  4IYP C;  2NPP C;  2O8A A;  4G9J A;  1HPU A;  1S3L A;  4V0W A;  4JA7 A;  1FJM A;  4MOY A;  3HVQ A;  1XM7 A;  4UT3 B;  3C5W C;  1XZW A;  4O4K A;  4Q7F A;  2IE4 C;  3ZTV A;  4V0V A;  5IOH A;  1S70 A;  1V73 A;  4YKE A;  4H2B A;  1AUI A;  3ZU0 A;  4UT3 A;  5INB A;  4TUI A;  5F3W A;  3H69 A;  1Z2X A;  1IT6 A;  4HD0 A;  2Z1A A;  3K7V C;  4MOV A;  5J28 A;  2QFR A;  1QHW A;  3IVD A;  2GJU A;  3DW8 C;  1T71 A;  2ZO9 B;  3AV0 A;  3H60 A;  2HYP A;  4ORA A;  3QFK A;  3RL5 A;  2WDC A;  2YEQ A;  1W24 A;  1UF3 A;  4I5L C;  4M0V A;  4O24 A;  3H68 A;  2WDD A;  3E7A A;  3C9F A;  2WDE A;  3V4Y A;  2A22 A;  3IVE A;  4ORB A;  3CK2 A;  3DSD A;  2HYO A;  3RQZ A;  1U32 A;  2DFJ A;  3H61 A;  3DSC A;  2BCD A;  3GVE A;  3H63 A;  2IE3 C;  4NZV A;  4ZX2 A;  4ORC A;  3LL8 A;  5GTU A;  2DXN A;  4ZVZ A;  2KKN A;  5C1V A;  4B2O A;  5B8I A;  2HY1 A;  3FGA C;  3QFM A;  3RL3 A;  2YVT A;  3QG5 C;  4OR9 A;  1G5B A;  1OIE A;  3K7W C;  4H2I A;  2CV9 A;  2NYL C;  3QFO A;  4H1S A;  1S3M A;  4LU9 A;  1WAR A;  4FBQ A;  3D03 A;  4I5N C;  5JPE A;  2ZOA A;  4FCX A;  2NXF A;  4FBK A;  4XPN A;  3TGH A;  5EQV A;  3AUZ A;  3EGH A;  4MP0 A;  4TUG A;  4WWL A;  3JYF A;  4V0X A;  4F0Z A;  3THO B;  2BDX A;  1S8E A;  1SU1 A;  2Z06 A;  3N5U A;  4DT2 A;  2O8G A;  3H67 A;  3FLO A;  2Z72 A;  2IAE C; 
#chains in the Genus database with same CATH homology
 1M63 A;  1OID A;  3E0J A;  1TCO A;  4J6O A;  1S3N A;  2USH A;  3ICF A;  1HO5 A;  4LTY A;  5DNY A;  3IB8 A;  1OI8 A;  3P71 C;  1KBP A;  3H64 A;  1WAO 1;  4H2G A;  2DXL A;  3IB7 A;  2WDF A;  1II7 A;  2BQ8 X;  5JJT A;  4UT2 A;  2QFP A;  1UTE A;  3EGG A;  4KBP A;  4UWQ A;  3PSO A;  4H2F A;  5JPF A;  3PSN A;  1MF8 A;  2NYM C;  4DSY A;  4LAC C;  2Q8U A;  1T70 A;  3THN A;  2XMO A;  3KBP A;  4O5G A;  1NNW A;  2JOG A;  5HPE A;  1JK7 A;  4JA9 A;  1Z2W A;  4IL1 A;  3T1I A;  2P6B A;  2QJC A;  2ZBM A;  1HP1 A;  4H1Y P;  2R17 A;  3QFN A;  4O43 A;  2AHD A;  4DHL A;  3E7B A;  1S95 A;  3H66 A;  4FBW A;  3RL4 A;  1QFC A;  1USH A;  3H62 B;  4KKZ A;  4IYP C;  2NPP C;  2O8A A;  4G9J A;  1HPU A;  1S3L A;  4V0W A;  4JA7 A;  1FJM A;  4MOY A;  3HVQ A;  1XM7 A;  4UT3 B;  3C5W C;  1XZW A;  4O4K A;  4Q7F A;  2IE4 C;  3ZTV A;  4V0V A;  5IOH A;  1S70 A;  1V73 A;  4YKE A;  4H2B A;  1AUI A;  3ZU0 A;  4UT3 A;  5INB A;  4TUI A;  5F3W A;  3H69 A;  1Z2X A;  1IT6 A;  4HD0 A;  2Z1A A;  3K7V C;  4MOV A;  5J28 A;  2QFR A;  1QHW A;  3IVD A;  2GJU A;  3DW8 C;  1T71 A;  2ZO9 B;  3AV0 A;  3H60 A;  2HYP A;  4ORA A;  3QFK A;  3RL5 A;  2WDC A;  2YEQ A;  1W24 A;  1UF3 A;  4I5L C;  4M0V A;  4O24 A;  3H68 A;  2WDD A;  3E7A A;  3C9F A;  2WDE A;  3V4Y A;  2A22 A;  3IVE A;  4ORB A;  3CK2 A;  3DSD A;  2HYO A;  3RQZ A;  1U32 A;  2DFJ A;  3H61 A;  3DSC A;  2BCD A;  3GVE A;  3H63 A;  2IE3 C;  4NZV A;  4ZX2 A;  4ORC A;  3LL8 A;  5GTU A;  2DXN A;  4ZVZ A;  2KKN A;  5C1V A;  4B2O A;  5B8I A;  2HY1 A;  3FGA C;  3QFM A;  3RL3 A;  2YVT A;  3QG5 C;  4OR9 A;  1G5B A;  1OIE A;  3K7W C;  4H2I A;  2CV9 A;  2NYL C;  3QFO A;  4H1S A;  1S3M A;  4LU9 A;  1WAR A;  4FBQ A;  3D03 A;  4I5N C;  5JPE A;  2ZOA A;  4FCX A;  2NXF A;  4FBK A;  4XPN A;  3TGH A;  5EQV A;  3AUZ A;  3EGH A;  4MP0 A;  4TUG A;  4WWL A;  3JYF A;  4V0X A;  4F0Z A;  3THO B;  2BDX A;  1S8E A;  1SU1 A;  2Z06 A;  3N5U A;  4DT2 A;  2O8G A;  3H67 A;  3FLO A;  2Z72 A;  2IAE C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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