3HOWL

Complete rna polymerase ii elongation complex iii with a t-u mismatch and a frayed rna 3'-uridine
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
44
structure length
44
Chain Sequence
LKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
pubmed doi rcsb
molecule tags Transcription,transferase/dna/rna hybrid
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 2
structure length 44
sequence length 44
ec nomenclature
pdb deposition date 2009-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 3howL00
1TWFL 4Y52L 3GTOL 3M3YL 3HOVL 5M5YL 3S17L 3HOYL 5C3EL 3GTPL 1I3QL 4BY1L 3RZOL 3H0GL 4C3HL 2JA5L 4A3ML 4A3GL 5C4XL 1TWHL 1Y1VL 4X6AL 1TWAL 4A3CL 3GTGL 2PMZP 4C3JL 2NVXL 5IYDL 5FJ8L 3S1NL 4A3KL 5IP7L 4BBSL 3GTQL 4Y7NL 2JA6L 2B63L 2JA7L 2NVYL 4C2M1 5M3ML 5M5XL 1SFOL 3FKIL 2R7ZL 3HOWL 3S1ML 2JA8L 3S16L 3GTML 3HOZL 3PO3L 4A3BL 4BXXL 2VUML 3HOXL 1I6HL 1I50L 3I4ML 3PO2L 3GTJL 4A3FL 3K7AL 5IYBL 2R93L 1R9TL 3H3VM 5IP9L 1Y1WL 2R92L 4C3IL 2WAQP 1WCML 2E2IL 3S1QL 5M3FL 1K83L 3GTLL 4BY7L 2NVTL 4A3IL 3S2DL 3M4OL 2E2JL 1TWCL 3HKZP 4QIWP 3CQZL 3S1RL 4A93L 5FLML 4A3JL 2WB1P 3S2HL 4A3DL 4BBRL 3RZDL 4A3EL 4AYBP 2E2HL 1TWGL 2YU9L 3HOUL 4A3LL 3GTKL 5C44L 3S15L 5IYCL 3S14L 3I4NL 2Y0SP 2NVQL 5M5WL 5C4JL
chains in the Genus database with same CATH superfamily
5AI2A 5RXNA 3M3YL 4ME3A 2PSMC 3PKIA 4AHXA 2ZIXA 3J7Z1 4LHNA 3HAXC 4UY81 4A3GL 2PVXA 1Y1VL 1T9QA 4A3CL 3SS2A 3QVDA 4Y7NL 2JA7L 3A44A 2XJQA 3H99A 3S1ML 3P8BA 2RFKB 3HOZL 1WJVA 4YWLA 1LKMA 2HVYC 1NXGA 5MFZA 1RDVA 4B8CD 4AHZA 3LWRB 2HR5A 2R92L 1Y1WL 2AQCA 4C3IL 1PFUA 4JAGA 2VL6A 1YUZA 1K83L 4XXBB 2NVTL 4A3IL 2JI3A 4AHWA 3S2DL 4TPUA 2E2JL 3HKZP 3KYUA 4V196 4A93L 5FLML 3PIP1 1VCXA 3S2HL 1RWDA 2M4VA 2CKAA 4A3EL 4K9FA 1YV1A 4XGHA 4A3LL 1BRFA 5C44L 2CR8A 2NVQL 1RDGA 3GTOL 2A68D 5M5YL 2XJUA 4RXNA 2NYDA 1SMUA 1YUXA 5MF6A 3HJWB 3PZAA 1QYBA 2AUSB 3B08B 1I3QL 3LWOB 4BY1L 2KKDA 4U671 5GAGc 4X6AL 1DX8A 3H9CA 3GTGL 1YK5A 2DSXA 1R0FA 2PMZP 4C3JL 2NVXL 3S1NL 4A3KL 7RXNA 2V0EA 4AHYA 3HOWL 2JA8L 1OWCA 2Z3QB 1VZIA 2M6PA 4TVMA 1S2ZA 3P2AA 3HOXL 1I6HL 5GAHc 1VZHA 1QCVA 3NFPI 5IY0A 1FHMA 1E8JA 3LNLA 3VPBE 3K7AL 4AR5A 3H3VM 3MQKB 1IW7D 1PFYA 2WAQP 1NNQA 2A6ED 2V0FA 4GS7D 1T9PA 5M3FL 2MS3A 5JVG1 4JAEA 3GTLL 3KYYA 5GADc 1IU5A 3M4OL 2RDVA 2C6AA 1CAAA 4A3JL 2WB1P 2Z3RB 4AI0A 4BBRL 5DM71 4AR6A 2E2HL 1RYQA 3HJYB 1TWGL 3LWPB 1DVBA 1R0JA 4JAFA 2J9UB 1SMMA 3S14L 1S24A 1TWFL 1R0GA 2APOB 2QL0A 5EIOC 3LPEB 2L0ZA 1B71A 4AI1A 1R0HA 3GTPL 1PFVA 3RZOL 3H0GL 4AR3A 2JA5L 4A3ML 1RB9A 3B0AB 1IRNA 2KN9A 4ZN1B 4G6BA 5IYDL 1B2OA 3MSUA 5FJ8L 1SMWA 1H7VA 1BE7A 3PIO1 5AI3A 2EY4E 1BFYA 2B63L 2NVYL 5JVH1 1SFOL 3FKIL 3S16L 1LKPA 3KYWA 3GTML 5H1Sc 3PO3L 3RZTA 5DM61 1C09A 1PZXA 1I50L 3PWFA 3ZG6A 2A69D 3I4ML 3MPSA 3J7Y1 3GTJL 3H97A 8RXNA 4E6YA 1ODHA 4AI2A 3WWNB 5K2ME 5IP9L 2AYJA 2H12A 3KYXA 2XJPA 1QQTA 3S1QL 4WFN1 2CKCA 2BE5D 5MFPA 1TWCL 4QIWP 2XJRA 4YWMA 3QQCE 4A3DL 1YK4A 3RZDL 3WWLA 2YU9L 2ERJA 4AR4A 3IU3I 1RYTA 3PL5A 4LHLA 3I4NL 4AI3A 1VZGA 4POFA 4Y52L 3HOVL 3S17L 3HOYL 5C3EL 1IROA 3RYGA 2PVEA 1LKOA 3H9BA 1CADA 4C3HL 2B5ID 5C4XL 5MGNA 1TWHL 4ZN3B 1TWAL 1S30A 1Z92B 5IP7L 2C6BA 2XJSA 4BBSL 2O5JD 3GTQL 1LTLA 3RZ6A 2JA6L 1FHHA 4C2M1 5M3ML 5M5XL 2JI1A 4JADA 2R7ZL 2M4YA 3LWQB 1OWBA 3FDJA 2M6OA 1IU6A 4A3BL 3JR7A 5AN9H 4BXXL 2VUML 1B2JA 6RXNA 2A6HD 3LWVB 3PO2L 2GMGA 2XJVA 4A3FL 5IYBL 2R93L 2XJTA 1R9TL 1JYBA 5GAEc 1WCML 2E2IL 1F4LA 1BQ9A 2JI2A 3K35A 1B13A 2ERSA 4BY7L 2PPTA 1R0IA 1P7PA 3PKJA 3CQZL 3S1RL 5MLC3 2K2DA 3KYVA 1ZRPA 1PFWA 4AYBP 3HOUL 5EINC 2V3BB 3GTKL 1T9OA 3S15L 5IYCL 2LCQA 1BQ8A 2Y0SP 1NXEA 2PYAA 5M5WL 5C4JL 4POGA
chains in the Genus database with same CATH topology
1TWFL 4Y52L 3GTOL 3M3YL 3HOVL 5M5YL 3S17L 3HOYL 5C3EL 3GTPL 1I3QL 4BY1L 3RZOL 3H0GL 4C3HL 2JA5L 4A3ML 4A3GL 5C4XL 1TWHL 1Y1VL 4X6AL 1TWAL 4A3CL 3GTGL 2PMZP 4C3JL 2NVXL 5IYDL 5FJ8L 3S1NL 4A3KL 5IP7L 4BBSL 3GTQL 4Y7NL 2JA6L 2B63L 2JA7L 2NVYL 4C2M1 5M3ML 5M5XL 1SFOL 3FKIL 2R7ZL 3HOWL 3S1ML 2JA8L 3S16L 3GTML 3HOZL 3PO3L 4A3BL 4BXXL 2VUML 3HOXL 1I6HL 1I50L 3I4ML 3PO2L 3GTJL 4A3FL 3K7AL 5IYBL 2R93L 1R9TL 3H3VM 5IP9L 1Y1WL 2R92L 4C3IL 2WAQP 1WCML 2E2IL 3S1QL 5M3FL 1K83L 3GTLL 4BY7L 2NVTL 4A3IL 3S2DL 3M4OL 2E2JL 1TWCL 3HKZP 4QIWP 3CQZL 3S1RL 4A93L 5FLML 4A3JL 2WB1P 3S2HL 4A3DL 4BBRL 3RZDL 4A3EL 4AYBP 2E2HL 1TWGL 2YU9L 3HOUL 4A3LL 3GTKL 5C44L 3S15L 5IYCL 3S14L 3I4NL 2Y0SP 2NVQL 5M5WL 5C4JL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TWF L;  4Y52 L;  3GTO L;  3M3Y L;  3HOV L;  5M5Y L;  3S17 L;  3HOY L;  5C3E L;  3GTP L;  1I3Q L;  4BY1 L;  3RZO L;  3H0G L;  4C3H L;  2JA5 L;  4A3M L;  4A3G L;  5C4X L;  1TWH L;  1Y1V L;  4X6A L;  1TWA L;  4A3C L;  3GTG L;  2PMZ P;  4C3J L;  2NVX L;  5IYD L;  5FJ8 L;  3S1N L;  4A3K L;  5IP7 L;  4BBS L;  3GTQ L;  4Y7N L;  2JA6 L;  2B63 L;  2JA7 L;  2NVY L;  4C2M 1;  5M3M L;  5M5X L;  1SFO L;  3FKI L;  2R7Z L;  3HOW L;  3S1M L;  2JA8 L;  3S16 L;  3GTM L;  3HOZ L;  3PO3 L;  4A3B L;  4BXX L;  2VUM L;  3HOX L;  1I6H L;  1I50 L;  3I4M L;  3PO2 L;  3GTJ L;  4A3F L;  3K7A L;  5IYB L;  2R93 L;  1R9T L;  3H3V M;  5IP9 L;  1Y1W L;  2R92 L;  4C3I L;  2WAQ P;  1WCM L;  2E2I L;  3S1Q L;  5M3F L;  1K83 L;  3GTL L;  4BY7 L;  2NVT L;  4A3I L;  3S2D L;  3M4O L;  2E2J L;  1TWC L;  3HKZ P;  4QIW P;  3CQZ L;  3S1R L;  4A93 L;  5FLM L;  4A3J L;  2WB1 P;  3S2H L;  4A3D L;  4BBR L;  3RZD L;  4A3E L;  4AYB P;  2E2H L;  1TWG L;  2YU9 L;  3HOU L;  4A3L L;  3GTK L;  5C44 L;  3S15 L;  5IYC L;  3S14 L;  3I4N L;  2Y0S P;  2NVQ L;  5M5W L;  5C4J L; 
#chains in the Genus database with same CATH topology
 5AI2 A;  5RXN A;  3M3Y L;  4ME3 A;  2PSM C;  3PKI A;  4AHX A;  2ZIX A;  3J7Z 1;  4LHN A;  3HAX C;  4UY8 1;  4A3G L;  2PVX A;  1Y1V L;  1T9Q A;  4A3C L;  3SS2 A;  3QVD A;  4Y7N L;  2JA7 L;  3A44 A;  2XJQ A;  3H99 A;  3S1M L;  3P8B A;  2RFK B;  3HOZ L;  1WJV A;  4YWL A;  1LKM A;  2HVY C;  1NXG A;  5MFZ A;  1RDV A;  4B8C D;  4AHZ A;  3LWR B;  2HR5 A;  2R92 L;  1Y1W L;  2AQC A;  4C3I L;  1PFU A;  4JAG A;  2VL6 A;  1YUZ A;  1K83 L;  4XXB B;  2NVT L;  4A3I L;  2JI3 A;  4AHW A;  3S2D L;  4TPU A;  2E2J L;  3HKZ P;  3KYU A;  4V19 6;  4A93 L;  5FLM L;  3PIP 1;  1VCX A;  3S2H L;  1RWD A;  2M4V A;  2CKA A;  4A3E L;  4K9F A;  1YV1 A;  4XGH A;  4A3L L;  1BRF A;  5C44 L;  2CR8 A;  2NVQ L;  1RDG A;  3GTO L;  2A68 D;  5M5Y L;  2XJU A;  4RXN A;  2NYD A;  1SMU A;  1YUX A;  5MF6 A;  3HJW B;  3PZA A;  1QYB A;  2AUS B;  3B08 B;  1I3Q L;  3LWO B;  4BY1 L;  2KKD A;  4U67 1;  5GAG c;  4X6A L;  1DX8 A;  3H9C A;  3GTG L;  1YK5 A;  2DSX A;  1R0F A;  2PMZ P;  4C3J L;  2NVX L;  3S1N L;  4A3K L;  7RXN A;  2V0E A;  4AHY A;  3HOW L;  2JA8 L;  1OWC A;  2Z3Q B;  1VZI A;  2M6P A;  4TVM A;  1S2Z A;  3P2A A;  3HOX L;  1I6H L;  5GAH c;  1VZH A;  1QCV A;  3NFP I;  5IY0 A;  1FHM A;  1E8J A;  3LNL A;  3VPB E;  3K7A L;  4AR5 A;  3H3V M;  3MQK B;  1IW7 D;  1PFY A;  2WAQ P;  1NNQ A;  2A6E D;  2V0F A;  4GS7 D;  1T9P A;  5M3F L;  2MS3 A;  5JVG 1;  4JAE A;  3GTL L;  3KYY A;  5GAD c;  1IU5 A;  3M4O L;  2RDV A;  2C6A A;  1CAA A;  4A3J L;  2WB1 P;  2Z3R B;  4AI0 A;  4BBR L;  5DM7 1;  4AR6 A;  2E2H L;  1RYQ A;  3HJY B;  1TWG L;  3LWP B;  1DVB A;  1R0J A;  4JAF A;  2J9U B;  1SMM A;  3S14 L;  1S24 A;  1TWF L;  1R0G A;  2APO B;  2QL0 A;  5EIO C;  3LPE B;  2L0Z A;  1B71 A;  4AI1 A;  1R0H A;  3GTP L;  1PFV A;  3RZO L;  3H0G L;  4AR3 A;  2JA5 L;  4A3M L;  1RB9 A;  3B0A B;  1IRN A;  2KN9 A;  4ZN1 B;  4G6B A;  5IYD L;  1B2O A;  3MSU A;  5FJ8 L;  1SMW A;  1H7V A;  1BE7 A;  3PIO 1;  5AI3 A;  2EY4 E;  1BFY A;  2B63 L;  2NVY L;  5JVH 1;  1SFO L;  3FKI L;  3S16 L;  1LKP A;  3KYW A;  3GTM L;  5H1S c;  3PO3 L;  3RZT A;  5DM6 1;  1C09 A;  1PZX A;  1I50 L;  3PWF A;  3ZG6 A;  2A69 D;  3I4M L;  3MPS A;  3J7Y 1;  3GTJ L;  3H97 A;  8RXN A;  4E6Y A;  1ODH A;  4AI2 A;  3WWN B;  5K2M E;  5IP9 L;  2AYJ A;  2H12 A;  3KYX A;  2XJP A;  1QQT A;  3S1Q L;  4WFN 1;  2CKC A;  2BE5 D;  5MFP A;  1TWC L;  4QIW P;  2XJR A;  4YWM A;  3QQC E;  4A3D L;  1YK4 A;  3RZD L;  3WWL A;  2YU9 L;  2ERJ A;  4AR4 A;  3IU3 I;  1RYT A;  3PL5 A;  4LHL A;  3I4N L;  4AI3 A;  1VZG A;  4POF A;  4Y52 L;  3HOV L;  3S17 L;  3HOY L;  5C3E L;  1IRO A;  3RYG A;  2PVE A;  1LKO A;  3H9B A;  1CAD A;  4C3H L;  2B5I D;  5C4X L;  5MGN A;  1TWH L;  4ZN3 B;  1TWA L;  1S30 A;  1Z92 B;  5IP7 L;  2C6B A;  2XJS A;  4BBS L;  2O5J D;  3GTQ L;  1LTL A;  3RZ6 A;  2JA6 L;  1FHH A;  4C2M 1;  5M3M L;  5M5X L;  2JI1 A;  4JAD A;  2R7Z L;  2M4Y A;  3LWQ B;  1OWB A;  3FDJ A;  2M6O A;  1IU6 A;  4A3B L;  3JR7 A;  5AN9 H;  4BXX L;  2VUM L;  1B2J A;  6RXN A;  2A6H D;  3LWV B;  3PO2 L;  2GMG A;  2XJV A;  4A3F L;  5IYB L;  2R93 L;  2XJT A;  1R9T L;  1JYB A;  5GAE c;  1WCM L;  2E2I L;  1F4L A;  1BQ9 A;  2JI2 A;  3K35 A;  1B13 A;  2ERS A;  4BY7 L;  2PPT A;  1R0I A;  1P7P A;  3PKJ A;  3CQZ L;  3S1R L;  5MLC 3;  2K2D A;  3KYV A;  1ZRP A;  1PFW A;  4AYB P;  3HOU L;  5EIN C;  2V3B B;  3GTK L;  1T9O A;  3S15 L;  5IYC L;  2LCQ A;  1BQ8 A;  2Y0S P;  1NXE A;  2PYA A;  5M5W L;  5C4J L;  4POG A; 
#chains in the Genus database with same CATH homology
 1TWF L;  4Y52 L;  3GTO L;  3M3Y L;  3HOV L;  5M5Y L;  3S17 L;  3HOY L;  5C3E L;  3GTP L;  1I3Q L;  4BY1 L;  3RZO L;  3H0G L;  4C3H L;  2JA5 L;  4A3M L;  4A3G L;  5C4X L;  1TWH L;  1Y1V L;  4X6A L;  1TWA L;  4A3C L;  3GTG L;  2PMZ P;  4C3J L;  2NVX L;  5IYD L;  5FJ8 L;  3S1N L;  4A3K L;  5IP7 L;  4BBS L;  3GTQ L;  4Y7N L;  2JA6 L;  2B63 L;  2JA7 L;  2NVY L;  4C2M 1;  5M3M L;  5M5X L;  1SFO L;  3FKI L;  2R7Z L;  3HOW L;  3S1M L;  2JA8 L;  3S16 L;  3GTM L;  3HOZ L;  3PO3 L;  4A3B L;  4BXX L;  2VUM L;  3HOX L;  1I6H L;  1I50 L;  3I4M L;  3PO2 L;  3GTJ L;  4A3F L;  3K7A L;  5IYB L;  2R93 L;  1R9T L;  3H3V M;  5IP9 L;  1Y1W L;  2R92 L;  4C3I L;  2WAQ P;  1WCM L;  2E2I L;  3S1Q L;  5M3F L;  1K83 L;  3GTL L;  4BY7 L;  2NVT L;  4A3I L;  3S2D L;  3M4O L;  2E2J L;  1TWC L;  3HKZ P;  4QIW P;  3CQZ L;  3S1R L;  4A93 L;  5FLM L;  4A3J L;  2WB1 P;  3S2H L;  4A3D L;  4BBR L;  3RZD L;  4A3E L;  4AYB P;  2E2H L;  1TWG L;  2YU9 L;  3HOU L;  4A3L L;  3GTK L;  5C44 L;  3S15 L;  5IYC L;  3S14 L;  3I4N L;  2Y0S P;  2NVQ L;  5M5W L;  5C4J L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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