3C5WC

Complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
304
structure length
294
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPTPDYFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PP2A A subunit
total genus 107
structure length 294
sequence length 304
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3c5wC00
4I5LC 1OI8A 5GTUA 3H61A 1II7A 4JA7A 4TUIA 1Z2WA 3P71C 4MOVA 1WAO1 4O4KA 2O8GA 2NYMC 2USHA 4V0WA 2BQ8X 2Z72A 2O8AA 2KKNA 3RL4A 3EGHA 1WARA 4Q7FA 1AUIA 4H2FA 5B8IA 2XMOA 2YVTA 4DT2A 3JYFA 2IE4C 4FCXA 4IL1A 4UWQA 1HPUA 1M63A 1S95A 1S70A 3H69A 1HO5A 2NPPC 2WDCA 2HYPA 2JOGA 2HYOA 1HP1A 4NZVA 4H2BA 5J28A 4MP0A 4LU9A 4M0VA 4J6OA 4O24A 1V73A 1XZWA 4DHLA 3IVDA 1S3MA 3FGAC 3H60A 1JK7A 3C9FA 4FBQA 3E7AA 4O5GA 1Z2XA 4F0ZA 3QFNA 2NXFA 3K7VC 3THNA 2IAEC 4B2OA 4ZX2A 5EQVA 1UF3A 3CK2A 2A22A 4FBKA 3IVEA 4G9JA 1TCOA 2WDEA 4MOYA 1QFCA 3H62B 1QHWA 3H68A 1S3NA 3HVQA 3QFOA 1OIDA 4KKZA 4H2IA 4LTYA 2Z1AA 3PSOA 4H1SA 4LACC 3H66A 3RL3A 3H67A 4H1YP 1IT6A 3DW8C 3H63A 3ZTVA 4I5NC 4TUGA 3QG5C 2QFPA 4ORCA 4V0XA 3K7WC 2Q8UA 3TGHA 4DSYA 4FBWA 3KBPA 5DNYA 2IE3C 1U32A 4UT2A 2WDDA 1SU1A 1T71A 3IB8A 5INBA 3AUZA 5F3WA 4JA9A 2QJCA 3T1IA 5JJTA 1FJMA 4ORBA 5HPEA 3THOB 3ZU0A 3AV0A 4IYPC 4H2GA 4ZVZA 2WDFA 4YKEA 2CV9A 3DSCA 4KBPA 4HD0A 4WWLA 3GVEA 4XPNA 2Z06A 1S8EA 4O43A 3E7BA 3C5WC 5C1VA 1MF8A 5JPEA 1S3LA 1G5BA 3ICFA 3QFMA 2HY1A 2QFRA 1OIEA 1T70A 4V0VA 5IOHA 1W24A 2R17A 4OR9A 3RQZA 2P6BA 1USHA 2GJUA 2AHDA 2ZBMA 1XM7A 1NNWA 3LL8A 3DSDA 3QFKA 5JPFA 2BDXA 2NYLC 3RL5A 1KBPA 3IB7A 3PSNA 4ORAA 2DFJA 4UT3A 3N5UA 4UT3B 3V4YA 3EGGA 2BCDA 1UTEA 3H64A
chains in the Genus database with same CATH superfamily
4I5LC 1OI8A 5GTUA 3H61A 1II7A 2ZO9B 4JA7A 4TUIA 1Z2WA 3P71C 4MOVA 1WAO1 4O4KA 2O8GA 2NYMC 2USHA 4V0WA 2BQ8X 2Z72A 2O8AA 2KKNA 3RL4A 3EGHA 1WARA 4Q7FA 1AUIA 4H2FA 5B8IA 2XMOA 2YVTA 4DT2A 3JYFA 2IE4C 4FCXA 4IL1A 4UWQA 1HPUA 1M63A 1S95A 1S70A 3H69A 1HO5A 2NPPC 2WDCA 2HYPA 2JOGA 2HYOA 1HP1A 4NZVA 4H2BA 5J28A 4MP0A 4LU9A 4M0VA 4J6OA 4O24A 1V73A 1XZWA 4DHLA 3IVDA 1S3MA 3FGAC 3H60A 1JK7A 3C9FA 4FBQA 3E7AA 4O5GA 1Z2XA 4F0ZA 3QFNA 2NXFA 3K7VC 3THNA 2IAEC 4B2OA 4ZX2A 5EQVA 1UF3A 3CK2A 2A22A 4FBKA 2ZOAA 3IVEA 4G9JA 1TCOA 2WDEA 4MOYA 3FLOA 1QFCA 3H62B 1QHWA 3H68A 1S3NA 3HVQA 3QFOA 1OIDA 4KKZA 4H2IA 4LTYA 2Z1AA 3PSOA 4H1SA 4LACC 3H66A 3RL3A 3H67A 4H1YP 1IT6A 3DW8C 3H63A 3ZTVA 4I5NC 4TUGA 3QG5C 2QFPA 4ORCA 4V0XA 3K7WC 2Q8UA 3TGHA 4DSYA 4FBWA 3KBPA 5DNYA 2IE3C 1U32A 4UT2A 2WDDA 3E0JA 1SU1A 1T71A 3IB8A 5INBA 3D03A 2YEQA 3AUZA 5F3WA 4JA9A 2QJCA 3T1IA 5JJTA 1FJMA 4ORBA 5HPEA 3THOB 3ZU0A 3AV0A 4IYPC 4H2GA 4ZVZA 2WDFA 4YKEA 2CV9A 3DSCA 4KBPA 4HD0A 4WWLA 3GVEA 4XPNA 2Z06A 1S8EA 4O43A 3E7BA 3C5WC 5C1VA 1MF8A 5JPEA 1S3LA 1G5BA 3ICFA 3QFMA 2HY1A 2QFRA 1OIEA 1T70A 4V0VA 5IOHA 1W24A 2R17A 4OR9A 2DXNA 3RQZA 2P6BA 1USHA 2GJUA 2AHDA 2ZBMA 1XM7A 1NNWA 3LL8A 3DSDA 3QFKA 5JPFA 2BDXA 2NYLC 3RL5A 1KBPA 3IB7A 2DXLA 3PSNA 4ORAA 2DFJA 4UT3A 3N5UA 4UT3B 3V4YA 3EGGA 2BCDA 1UTEA 3H64A
chains in the Genus database with same CATH topology
4I5LC 1OI8A 5GTUA 3H61A 1II7A 2ZO9B 4JA7A 4TUIA 1Z2WA 3P71C 4MOVA 1WAO1 4O4KA 2O8GA 2NYMC 2USHA 4V0WA 2BQ8X 2Z72A 2O8AA 2KKNA 3RL4A 3EGHA 1WARA 4Q7FA 1AUIA 4H2FA 5B8IA 2XMOA 2YVTA 4DT2A 3JYFA 2IE4C 4FCXA 4IL1A 4UWQA 1HPUA 1M63A 1S95A 1S70A 3H69A 1HO5A 2NPPC 2WDCA 2HYPA 2JOGA 2HYOA 1HP1A 4NZVA 4H2BA 5J28A 4MP0A 4LU9A 4M0VA 4J6OA 4O24A 1V73A 1XZWA 4DHLA 3IVDA 1S3MA 3FGAC 3H60A 1JK7A 3C9FA 4FBQA 3E7AA 4O5GA 1Z2XA 4F0ZA 3QFNA 2NXFA 3K7VC 3THNA 2IAEC 4B2OA 4ZX2A 5EQVA 1UF3A 3CK2A 2A22A 4FBKA 2ZOAA 3IVEA 4G9JA 1TCOA 2WDEA 4MOYA 3FLOA 1QFCA 3H62B 1QHWA 3H68A 1S3NA 3HVQA 3QFOA 1OIDA 4KKZA 4H2IA 4LTYA 2Z1AA 3PSOA 4H1SA 4LACC 3H66A 3RL3A 3H67A 4H1YP 1IT6A 3DW8C 3H63A 3ZTVA 4I5NC 4TUGA 3QG5C 2QFPA 4ORCA 4V0XA 3K7WC 2Q8UA 3TGHA 4DSYA 4FBWA 3KBPA 5DNYA 2IE3C 1U32A 4UT2A 2WDDA 3E0JA 1SU1A 1T71A 3IB8A 5INBA 3D03A 2YEQA 3AUZA 5F3WA 4JA9A 2QJCA 3T1IA 5JJTA 1FJMA 4ORBA 5HPEA 3THOB 3ZU0A 3AV0A 4IYPC 4H2GA 4ZVZA 2WDFA 4YKEA 2CV9A 3DSCA 4KBPA 4HD0A 4WWLA 3GVEA 4XPNA 2Z06A 1S8EA 4O43A 3E7BA 3C5WC 5C1VA 1MF8A 5JPEA 1S3LA 1G5BA 3ICFA 3QFMA 2HY1A 2QFRA 1OIEA 1T70A 4V0VA 5IOHA 1W24A 2R17A 4OR9A 2DXNA 3RQZA 2P6BA 1USHA 2GJUA 2AHDA 2ZBMA 1XM7A 1NNWA 3LL8A 3DSDA 3QFKA 5JPFA 2BDXA 2NYLC 3RL5A 1KBPA 3IB7A 2DXLA 3PSNA 4ORAA 2DFJA 4UT3A 3N5UA 4UT3B 3V4YA 3EGGA 2BCDA 1UTEA 3H64A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4I5L C;  1OI8 A;  5GTU A;  3H61 A;  1II7 A;  4JA7 A;  4TUI A;  1Z2W A;  3P71 C;  4MOV A;  1WAO 1;  4O4K A;  2O8G A;  2NYM C;  2USH A;  4V0W A;  2BQ8 X;  2Z72 A;  2O8A A;  2KKN A;  3RL4 A;  3EGH A;  1WAR A;  4Q7F A;  1AUI A;  4H2F A;  5B8I A;  2XMO A;  2YVT A;  4DT2 A;  3JYF A;  2IE4 C;  4FCX A;  4IL1 A;  4UWQ A;  1HPU A;  1M63 A;  1S95 A;  1S70 A;  3H69 A;  1HO5 A;  2NPP C;  2WDC A;  2HYP A;  2JOG A;  2HYO A;  1HP1 A;  4NZV A;  4H2B A;  5J28 A;  4MP0 A;  4LU9 A;  4M0V A;  4J6O A;  4O24 A;  1V73 A;  1XZW A;  4DHL A;  3IVD A;  1S3M A;  3FGA C;  3H60 A;  1JK7 A;  3C9F A;  4FBQ A;  3E7A A;  4O5G A;  1Z2X A;  4F0Z A;  3QFN A;  2NXF A;  3K7V C;  3THN A;  2IAE C;  4B2O A;  4ZX2 A;  5EQV A;  1UF3 A;  3CK2 A;  2A22 A;  4FBK A;  3IVE A;  4G9J A;  1TCO A;  2WDE A;  4MOY A;  1QFC A;  3H62 B;  1QHW A;  3H68 A;  1S3N A;  3HVQ A;  3QFO A;  1OID A;  4KKZ A;  4H2I A;  4LTY A;  2Z1A A;  3PSO A;  4H1S A;  4LAC C;  3H66 A;  3RL3 A;  3H67 A;  4H1Y P;  1IT6 A;  3DW8 C;  3H63 A;  3ZTV A;  4I5N C;  4TUG A;  3QG5 C;  2QFP A;  4ORC A;  4V0X A;  3K7W C;  2Q8U A;  3TGH A;  4DSY A;  4FBW A;  3KBP A;  5DNY A;  2IE3 C;  1U32 A;  4UT2 A;  2WDD A;  1SU1 A;  1T71 A;  3IB8 A;  5INB A;  3AUZ A;  5F3W A;  4JA9 A;  2QJC A;  3T1I A;  5JJT A;  1FJM A;  4ORB A;  5HPE A;  3THO B;  3ZU0 A;  3AV0 A;  4IYP C;  4H2G A;  4ZVZ A;  2WDF A;  4YKE A;  2CV9 A;  3DSC A;  4KBP A;  4HD0 A;  4WWL A;  3GVE A;  4XPN A;  2Z06 A;  1S8E A;  4O43 A;  3E7B A;  3C5W C;  5C1V A;  1MF8 A;  5JPE A;  1S3L A;  1G5B A;  3ICF A;  3QFM A;  2HY1 A;  2QFR A;  1OIE A;  1T70 A;  4V0V A;  5IOH A;  1W24 A;  2R17 A;  4OR9 A;  3RQZ A;  2P6B A;  1USH A;  2GJU A;  2AHD A;  2ZBM A;  1XM7 A;  1NNW A;  3LL8 A;  3DSD A;  3QFK A;  5JPF A;  2BDX A;  2NYL C;  3RL5 A;  1KBP A;  3IB7 A;  3PSN A;  4ORA A;  2DFJ A;  4UT3 A;  3N5U A;  4UT3 B;  3V4Y A;  3EGG A;  2BCD A;  1UTE A;  3H64 A; 
#chains in the Genus database with same CATH topology
 4I5L C;  1OI8 A;  5GTU A;  3H61 A;  1II7 A;  2ZO9 B;  4JA7 A;  4TUI A;  1Z2W A;  3P71 C;  4MOV A;  1WAO 1;  4O4K A;  2O8G A;  2NYM C;  2USH A;  4V0W A;  2BQ8 X;  2Z72 A;  2O8A A;  2KKN A;  3RL4 A;  3EGH A;  1WAR A;  4Q7F A;  1AUI A;  4H2F A;  5B8I A;  2XMO A;  2YVT A;  4DT2 A;  3JYF A;  2IE4 C;  4FCX A;  4IL1 A;  4UWQ A;  1HPU A;  1M63 A;  1S95 A;  1S70 A;  3H69 A;  1HO5 A;  2NPP C;  2WDC A;  2HYP A;  2JOG A;  2HYO A;  1HP1 A;  4NZV A;  4H2B A;  5J28 A;  4MP0 A;  4LU9 A;  4M0V A;  4J6O A;  4O24 A;  1V73 A;  1XZW A;  4DHL A;  3IVD A;  1S3M A;  3FGA C;  3H60 A;  1JK7 A;  3C9F A;  4FBQ A;  3E7A A;  4O5G A;  1Z2X A;  4F0Z A;  3QFN A;  2NXF A;  3K7V C;  3THN A;  2IAE C;  4B2O A;  4ZX2 A;  5EQV A;  1UF3 A;  3CK2 A;  2A22 A;  4FBK A;  2ZOA A;  3IVE A;  4G9J A;  1TCO A;  2WDE A;  4MOY A;  3FLO A;  1QFC A;  3H62 B;  1QHW A;  3H68 A;  1S3N A;  3HVQ A;  3QFO A;  1OID A;  4KKZ A;  4H2I A;  4LTY A;  2Z1A A;  3PSO A;  4H1S A;  4LAC C;  3H66 A;  3RL3 A;  3H67 A;  4H1Y P;  1IT6 A;  3DW8 C;  3H63 A;  3ZTV A;  4I5N C;  4TUG A;  3QG5 C;  2QFP A;  4ORC A;  4V0X A;  3K7W C;  2Q8U A;  3TGH A;  4DSY A;  4FBW A;  3KBP A;  5DNY A;  2IE3 C;  1U32 A;  4UT2 A;  2WDD A;  3E0J A;  1SU1 A;  1T71 A;  3IB8 A;  5INB A;  3D03 A;  2YEQ A;  3AUZ A;  5F3W A;  4JA9 A;  2QJC A;  3T1I A;  5JJT A;  1FJM A;  4ORB A;  5HPE A;  3THO B;  3ZU0 A;  3AV0 A;  4IYP C;  4H2G A;  4ZVZ A;  2WDF A;  4YKE A;  2CV9 A;  3DSC A;  4KBP A;  4HD0 A;  4WWL A;  3GVE A;  4XPN A;  2Z06 A;  1S8E A;  4O43 A;  3E7B A;  3C5W C;  5C1V A;  1MF8 A;  5JPE A;  1S3L A;  1G5B A;  3ICF A;  3QFM A;  2HY1 A;  2QFR A;  1OIE A;  1T70 A;  4V0V A;  5IOH A;  1W24 A;  2R17 A;  4OR9 A;  2DXN A;  3RQZ A;  2P6B A;  1USH A;  2GJU A;  2AHD A;  2ZBM A;  1XM7 A;  1NNW A;  3LL8 A;  3DSD A;  3QFK A;  5JPF A;  2BDX A;  2NYL C;  3RL5 A;  1KBP A;  3IB7 A;  2DXL A;  3PSN A;  4ORA A;  2DFJ A;  4UT3 A;  3N5U A;  4UT3 B;  3V4Y A;  3EGG A;  2BCD A;  1UTE A;  3H64 A; 
#chains in the Genus database with same CATH homology
 4I5L C;  1OI8 A;  5GTU A;  3H61 A;  1II7 A;  2ZO9 B;  4JA7 A;  4TUI A;  1Z2W A;  3P71 C;  4MOV A;  1WAO 1;  4O4K A;  2O8G A;  2NYM C;  2USH A;  4V0W A;  2BQ8 X;  2Z72 A;  2O8A A;  2KKN A;  3RL4 A;  3EGH A;  1WAR A;  4Q7F A;  1AUI A;  4H2F A;  5B8I A;  2XMO A;  2YVT A;  4DT2 A;  3JYF A;  2IE4 C;  4FCX A;  4IL1 A;  4UWQ A;  1HPU A;  1M63 A;  1S95 A;  1S70 A;  3H69 A;  1HO5 A;  2NPP C;  2WDC A;  2HYP A;  2JOG A;  2HYO A;  1HP1 A;  4NZV A;  4H2B A;  5J28 A;  4MP0 A;  4LU9 A;  4M0V A;  4J6O A;  4O24 A;  1V73 A;  1XZW A;  4DHL A;  3IVD A;  1S3M A;  3FGA C;  3H60 A;  1JK7 A;  3C9F A;  4FBQ A;  3E7A A;  4O5G A;  1Z2X A;  4F0Z A;  3QFN A;  2NXF A;  3K7V C;  3THN A;  2IAE C;  4B2O A;  4ZX2 A;  5EQV A;  1UF3 A;  3CK2 A;  2A22 A;  4FBK A;  2ZOA A;  3IVE A;  4G9J A;  1TCO A;  2WDE A;  4MOY A;  3FLO A;  1QFC A;  3H62 B;  1QHW A;  3H68 A;  1S3N A;  3HVQ A;  3QFO A;  1OID A;  4KKZ A;  4H2I A;  4LTY A;  2Z1A A;  3PSO A;  4H1S A;  4LAC C;  3H66 A;  3RL3 A;  3H67 A;  4H1Y P;  1IT6 A;  3DW8 C;  3H63 A;  3ZTV A;  4I5N C;  4TUG A;  3QG5 C;  2QFP A;  4ORC A;  4V0X A;  3K7W C;  2Q8U A;  3TGH A;  4DSY A;  4FBW A;  3KBP A;  5DNY A;  2IE3 C;  1U32 A;  4UT2 A;  2WDD A;  3E0J A;  1SU1 A;  1T71 A;  3IB8 A;  5INB A;  3D03 A;  2YEQ A;  3AUZ A;  5F3W A;  4JA9 A;  2QJC A;  3T1I A;  5JJT A;  1FJM A;  4ORB A;  5HPE A;  3THO B;  3ZU0 A;  3AV0 A;  4IYP C;  4H2G A;  4ZVZ A;  2WDF A;  4YKE A;  2CV9 A;  3DSC A;  4KBP A;  4HD0 A;  4WWL A;  3GVE A;  4XPN A;  2Z06 A;  1S8E A;  4O43 A;  3E7B A;  3C5W C;  5C1V A;  1MF8 A;  5JPE A;  1S3L A;  1G5B A;  3ICF A;  3QFM A;  2HY1 A;  2QFR A;  1OIE A;  1T70 A;  4V0V A;  5IOH A;  1W24 A;  2R17 A;  4OR9 A;  2DXN A;  3RQZ A;  2P6B A;  1USH A;  2GJU A;  2AHD A;  2ZBM A;  1XM7 A;  1NNW A;  3LL8 A;  3DSD A;  3QFK A;  5JPF A;  2BDX A;  2NYL C;  3RL5 A;  1KBP A;  3IB7 A;  2DXL A;  3PSN A;  4ORA A;  2DFJ A;  4UT3 A;  3N5U A;  4UT3 B;  3V4Y A;  3EGG A;  2BCD A;  1UTE A;  3H64 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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