3DW8C

Structure of a protein phosphatase 2a holoenzyme with b55 subunit
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 106
structure length 288
sequence length 288
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3dw8C00
2YVTA 3RL4A 3N5UA 2DFJA 3FGAC 5GTUA 2HY1A 1HP1A 4ORCA 5HPEA 3ICFA 3JYFA 5F3WA 4Q7FA 1II7A 1UTEA 1S3LA 3T1IA 3LL8A 4B2OA 1IT6A 5EQVA 3AUZA 2USHA 2NPPC 2P6BA 2ZBMA 3RQZA 4ZX2A 4H2GA 1XM7A 3QFOA 3PSNA 3AV0A 2XMOA 2BDXA 4JA9A 4LTYA 2WDEA 3EGHA 4O24A 2IAEC 4NZVA 2CV9A 4F0ZA 1S3MA 4UT3A 3QG5C 1NNWA 4JA7A 1S8EA 3HVQA 3K7WC 4ORBA 4DSYA 1T70A 3IVDA 4H2IA 1OIDA 4DHLA 4OR9A 3QFNA 3DSDA 1QFCA 1XZWA 1FJMA 4LACC 4FCXA 3IB8A 5JPEA 5JJTA 3C5WC 5J28A 3GVEA 3EGGA 4ZVZA 3IVEA 4I5NC 2JOGA 4MP0A 1MF8A 2NXFA 3DSCA 2WDDA 1S3NA 2O8AA 1JK7A 1OI8A 3P71C 1HPUA 3H68A 1WARA 3H63A 4FBQA 3E7AA 4ORAA 2IE3C 1Z2XA 4MOVA 3THNA 3THOB 5JPFA 2QJCA 1G5BA 4O5GA 1KBPA 2Z72A 4V0WA 4FBWA 4H2BA 2A22A 4V0XA 3DW8C 1W24A 2WDFA 4HD0A 2IE4C 2GJUA 4MOYA 4H1SA 4KKZA 4UT2A 5DNYA 3V4YA 4M0VA 1U32A 2R17A 1T71A 4IYPC 4H1YP 3K7VC 1SU1A 3H66A 4I5LC 2Q8UA 4YKEA 1M63A 1USHA 3IB7A 2Z06A 3ZTVA 4TUIA 2NYMC 4UT3B 3RL3A 3QFKA 2BQ8X 4WWLA 1WAO1 3H64A 3H62B 3KBPA 3ZU0A 1OIEA 2HYPA 3C9FA 3H69A 4H2FA 1S70A 1HO5A 2WDCA 3PSOA 4V0VA 1TCOA 2Z1AA 5B8IA 2QFRA 3H61A 2NYLC 1S95A 2AHDA 3QFMA 2BCDA 2QFPA 4TUGA 4UWQA 2HYOA 4KBPA 1V73A 2KKNA 3TGHA 1UF3A 4O4KA 5IOHA 3H60A 1AUIA 3H67A 5INBA 4IL1A 1QHWA 2O8GA 5C1VA 3E7BA 4FBKA 1Z2WA 4J6OA 4LU9A 4O43A 3RL5A 4DT2A 3CK2A 4XPNA 4G9JA
chains in the Genus database with same CATH superfamily
2YVTA 3RL4A 3N5UA 2DFJA 3FGAC 5GTUA 2HY1A 1HP1A 4ORCA 5HPEA 3ICFA 3JYFA 5F3WA 4Q7FA 1II7A 1UTEA 1S3LA 3T1IA 3LL8A 4B2OA 1IT6A 5EQVA 3AUZA 2USHA 2NPPC 2P6BA 2ZBMA 2DXNA 3RQZA 4ZX2A 4H2GA 1XM7A 3QFOA 3PSNA 3AV0A 2XMOA 2BDXA 4JA9A 4LTYA 2WDEA 3EGHA 4O24A 2IAEC 4NZVA 2CV9A 4F0ZA 1S3MA 4UT3A 3QG5C 1NNWA 4JA7A 1S8EA 3HVQA 3K7WC 4ORBA 4DSYA 1T70A 3IVDA 4H2IA 1OIDA 4DHLA 4OR9A 3QFNA 3DSDA 1QFCA 1XZWA 1FJMA 4LACC 4FCXA 3IB8A 5JPEA 5JJTA 3C5WC 5J28A 3GVEA 3EGGA 4ZVZA 3IVEA 4I5NC 2JOGA 4MP0A 1MF8A 2NXFA 3DSCA 2WDDA 1S3NA 2O8AA 1JK7A 1OI8A 3P71C 1HPUA 3H68A 1WARA 3H63A 4FBQA 3E7AA 4ORAA 2ZOAA 2IE3C 1Z2XA 4MOVA 3THNA 3THOB 5JPFA 2QJCA 1G5BA 4O5GA 1KBPA 2Z72A 4V0WA 4FBWA 4H2BA 3D03A 2A22A 4V0XA 3DW8C 1W24A 2WDFA 4HD0A 2IE4C 2GJUA 4MOYA 4H1SA 4KKZA 4UT2A 5DNYA 3V4YA 4M0VA 1U32A 2R17A 1T71A 4IYPC 4H1YP 3K7VC 1SU1A 3H66A 4I5LC 2Q8UA 3FLOA 4YKEA 1M63A 1USHA 3IB7A 2Z06A 3ZTVA 4TUIA 2NYMC 2ZO9B 4UT3B 3RL3A 3QFKA 2BQ8X 4WWLA 1WAO1 3H64A 3H62B 3KBPA 3ZU0A 1OIEA 2HYPA 3C9FA 3H69A 4H2FA 1S70A 1HO5A 2WDCA 3PSOA 4V0VA 1TCOA 2Z1AA 3E0JA 5B8IA 2QFRA 3H61A 2NYLC 1S95A 2AHDA 3QFMA 2BCDA 2QFPA 4TUGA 4UWQA 2HYOA 4KBPA 1V73A 2KKNA 3TGHA 1UF3A 4O4KA 5IOHA 3H60A 1AUIA 3H67A 5INBA 4IL1A 2DXLA 1QHWA 2O8GA 2YEQA 5C1VA 3E7BA 4FBKA 1Z2WA 4J6OA 4LU9A 4O43A 3RL5A 4DT2A 3CK2A 4XPNA 4G9JA
chains in the Genus database with same CATH topology
2YVTA 3RL4A 3N5UA 2DFJA 3FGAC 5GTUA 2HY1A 1HP1A 4ORCA 5HPEA 3ICFA 3JYFA 5F3WA 4Q7FA 1II7A 1UTEA 1S3LA 3T1IA 3LL8A 4B2OA 1IT6A 5EQVA 3AUZA 2USHA 2NPPC 2P6BA 2ZBMA 2DXNA 3RQZA 4ZX2A 4H2GA 1XM7A 3QFOA 3PSNA 3AV0A 2XMOA 2BDXA 4JA9A 4LTYA 2WDEA 3EGHA 4O24A 2IAEC 4NZVA 2CV9A 4F0ZA 1S3MA 4UT3A 3QG5C 1NNWA 4JA7A 1S8EA 3HVQA 3K7WC 4ORBA 4DSYA 1T70A 3IVDA 4H2IA 1OIDA 4DHLA 4OR9A 3QFNA 3DSDA 1QFCA 1XZWA 1FJMA 4LACC 4FCXA 3IB8A 5JPEA 5JJTA 3C5WC 5J28A 3GVEA 3EGGA 4ZVZA 3IVEA 4I5NC 2JOGA 4MP0A 1MF8A 2NXFA 3DSCA 2WDDA 1S3NA 2O8AA 1JK7A 1OI8A 3P71C 1HPUA 3H68A 1WARA 3H63A 4FBQA 3E7AA 4ORAA 2ZOAA 2IE3C 1Z2XA 4MOVA 3THNA 3THOB 5JPFA 2QJCA 1G5BA 4O5GA 1KBPA 2Z72A 4V0WA 4FBWA 4H2BA 3D03A 2A22A 4V0XA 3DW8C 1W24A 2WDFA 4HD0A 2IE4C 2GJUA 4MOYA 4H1SA 4KKZA 4UT2A 5DNYA 3V4YA 4M0VA 1U32A 2R17A 1T71A 4IYPC 4H1YP 3K7VC 1SU1A 3H66A 4I5LC 2Q8UA 3FLOA 4YKEA 1M63A 1USHA 3IB7A 2Z06A 3ZTVA 4TUIA 2NYMC 2ZO9B 4UT3B 3RL3A 3QFKA 2BQ8X 4WWLA 1WAO1 3H64A 3H62B 3KBPA 3ZU0A 1OIEA 2HYPA 3C9FA 3H69A 4H2FA 1S70A 1HO5A 2WDCA 3PSOA 4V0VA 1TCOA 2Z1AA 3E0JA 5B8IA 2QFRA 3H61A 2NYLC 1S95A 2AHDA 3QFMA 2BCDA 2QFPA 4TUGA 4UWQA 2HYOA 4KBPA 1V73A 2KKNA 3TGHA 1UF3A 4O4KA 5IOHA 3H60A 1AUIA 3H67A 5INBA 4IL1A 2DXLA 1QHWA 2O8GA 2YEQA 5C1VA 3E7BA 4FBKA 1Z2WA 4J6OA 4LU9A 4O43A 3RL5A 4DT2A 3CK2A 4XPNA 4G9JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YVT A;  3RL4 A;  3N5U A;  2DFJ A;  3FGA C;  5GTU A;  2HY1 A;  1HP1 A;  4ORC A;  5HPE A;  3ICF A;  3JYF A;  5F3W A;  4Q7F A;  1II7 A;  1UTE A;  1S3L A;  3T1I A;  3LL8 A;  4B2O A;  1IT6 A;  5EQV A;  3AUZ A;  2USH A;  2NPP C;  2P6B A;  2ZBM A;  3RQZ A;  4ZX2 A;  4H2G A;  1XM7 A;  3QFO A;  3PSN A;  3AV0 A;  2XMO A;  2BDX A;  4JA9 A;  4LTY A;  2WDE A;  3EGH A;  4O24 A;  2IAE C;  4NZV A;  2CV9 A;  4F0Z A;  1S3M A;  4UT3 A;  3QG5 C;  1NNW A;  4JA7 A;  1S8E A;  3HVQ A;  3K7W C;  4ORB A;  4DSY A;  1T70 A;  3IVD A;  4H2I A;  1OID A;  4DHL A;  4OR9 A;  3QFN A;  3DSD A;  1QFC A;  1XZW A;  1FJM A;  4LAC C;  4FCX A;  3IB8 A;  5JPE A;  5JJT A;  3C5W C;  5J28 A;  3GVE A;  3EGG A;  4ZVZ A;  3IVE A;  4I5N C;  2JOG A;  4MP0 A;  1MF8 A;  2NXF A;  3DSC A;  2WDD A;  1S3N A;  2O8A A;  1JK7 A;  1OI8 A;  3P71 C;  1HPU A;  3H68 A;  1WAR A;  3H63 A;  4FBQ A;  3E7A A;  4ORA A;  2IE3 C;  1Z2X A;  4MOV A;  3THN A;  3THO B;  5JPF A;  2QJC A;  1G5B A;  4O5G A;  1KBP A;  2Z72 A;  4V0W A;  4FBW A;  4H2B A;  2A22 A;  4V0X A;  3DW8 C;  1W24 A;  2WDF A;  4HD0 A;  2IE4 C;  2GJU A;  4MOY A;  4H1S A;  4KKZ A;  4UT2 A;  5DNY A;  3V4Y A;  4M0V A;  1U32 A;  2R17 A;  1T71 A;  4IYP C;  4H1Y P;  3K7V C;  1SU1 A;  3H66 A;  4I5L C;  2Q8U A;  4YKE A;  1M63 A;  1USH A;  3IB7 A;  2Z06 A;  3ZTV A;  4TUI A;  2NYM C;  4UT3 B;  3RL3 A;  3QFK A;  2BQ8 X;  4WWL A;  1WAO 1;  3H64 A;  3H62 B;  3KBP A;  3ZU0 A;  1OIE A;  2HYP A;  3C9F A;  3H69 A;  4H2F A;  1S70 A;  1HO5 A;  2WDC A;  3PSO A;  4V0V A;  1TCO A;  2Z1A A;  5B8I A;  2QFR A;  3H61 A;  2NYL C;  1S95 A;  2AHD A;  3QFM A;  2BCD A;  2QFP A;  4TUG A;  4UWQ A;  2HYO A;  4KBP A;  1V73 A;  2KKN A;  3TGH A;  1UF3 A;  4O4K A;  5IOH A;  3H60 A;  1AUI A;  3H67 A;  5INB A;  4IL1 A;  1QHW A;  2O8G A;  5C1V A;  3E7B A;  4FBK A;  1Z2W A;  4J6O A;  4LU9 A;  4O43 A;  3RL5 A;  4DT2 A;  3CK2 A;  4XPN A;  4G9J A; 
#chains in the Genus database with same CATH topology
 2YVT A;  3RL4 A;  3N5U A;  2DFJ A;  3FGA C;  5GTU A;  2HY1 A;  1HP1 A;  4ORC A;  5HPE A;  3ICF A;  3JYF A;  5F3W A;  4Q7F A;  1II7 A;  1UTE A;  1S3L A;  3T1I A;  3LL8 A;  4B2O A;  1IT6 A;  5EQV A;  3AUZ A;  2USH A;  2NPP C;  2P6B A;  2ZBM A;  2DXN A;  3RQZ A;  4ZX2 A;  4H2G A;  1XM7 A;  3QFO A;  3PSN A;  3AV0 A;  2XMO A;  2BDX A;  4JA9 A;  4LTY A;  2WDE A;  3EGH A;  4O24 A;  2IAE C;  4NZV A;  2CV9 A;  4F0Z A;  1S3M A;  4UT3 A;  3QG5 C;  1NNW A;  4JA7 A;  1S8E A;  3HVQ A;  3K7W C;  4ORB A;  4DSY A;  1T70 A;  3IVD A;  4H2I A;  1OID A;  4DHL A;  4OR9 A;  3QFN A;  3DSD A;  1QFC A;  1XZW A;  1FJM A;  4LAC C;  4FCX A;  3IB8 A;  5JPE A;  5JJT A;  3C5W C;  5J28 A;  3GVE A;  3EGG A;  4ZVZ A;  3IVE A;  4I5N C;  2JOG A;  4MP0 A;  1MF8 A;  2NXF A;  3DSC A;  2WDD A;  1S3N A;  2O8A A;  1JK7 A;  1OI8 A;  3P71 C;  1HPU A;  3H68 A;  1WAR A;  3H63 A;  4FBQ A;  3E7A A;  4ORA A;  2ZOA A;  2IE3 C;  1Z2X A;  4MOV A;  3THN A;  3THO B;  5JPF A;  2QJC A;  1G5B A;  4O5G A;  1KBP A;  2Z72 A;  4V0W A;  4FBW A;  4H2B A;  3D03 A;  2A22 A;  4V0X A;  3DW8 C;  1W24 A;  2WDF A;  4HD0 A;  2IE4 C;  2GJU A;  4MOY A;  4H1S A;  4KKZ A;  4UT2 A;  5DNY A;  3V4Y A;  4M0V A;  1U32 A;  2R17 A;  1T71 A;  4IYP C;  4H1Y P;  3K7V C;  1SU1 A;  3H66 A;  4I5L C;  2Q8U A;  3FLO A;  4YKE A;  1M63 A;  1USH A;  3IB7 A;  2Z06 A;  3ZTV A;  4TUI A;  2NYM C;  2ZO9 B;  4UT3 B;  3RL3 A;  3QFK A;  2BQ8 X;  4WWL A;  1WAO 1;  3H64 A;  3H62 B;  3KBP A;  3ZU0 A;  1OIE A;  2HYP A;  3C9F A;  3H69 A;  4H2F A;  1S70 A;  1HO5 A;  2WDC A;  3PSO A;  4V0V A;  1TCO A;  2Z1A A;  3E0J A;  5B8I A;  2QFR A;  3H61 A;  2NYL C;  1S95 A;  2AHD A;  3QFM A;  2BCD A;  2QFP A;  4TUG A;  4UWQ A;  2HYO A;  4KBP A;  1V73 A;  2KKN A;  3TGH A;  1UF3 A;  4O4K A;  5IOH A;  3H60 A;  1AUI A;  3H67 A;  5INB A;  4IL1 A;  2DXL A;  1QHW A;  2O8G A;  2YEQ A;  5C1V A;  3E7B A;  4FBK A;  1Z2W A;  4J6O A;  4LU9 A;  4O43 A;  3RL5 A;  4DT2 A;  3CK2 A;  4XPN A;  4G9J A; 
#chains in the Genus database with same CATH homology
 2YVT A;  3RL4 A;  3N5U A;  2DFJ A;  3FGA C;  5GTU A;  2HY1 A;  1HP1 A;  4ORC A;  5HPE A;  3ICF A;  3JYF A;  5F3W A;  4Q7F A;  1II7 A;  1UTE A;  1S3L A;  3T1I A;  3LL8 A;  4B2O A;  1IT6 A;  5EQV A;  3AUZ A;  2USH A;  2NPP C;  2P6B A;  2ZBM A;  2DXN A;  3RQZ A;  4ZX2 A;  4H2G A;  1XM7 A;  3QFO A;  3PSN A;  3AV0 A;  2XMO A;  2BDX A;  4JA9 A;  4LTY A;  2WDE A;  3EGH A;  4O24 A;  2IAE C;  4NZV A;  2CV9 A;  4F0Z A;  1S3M A;  4UT3 A;  3QG5 C;  1NNW A;  4JA7 A;  1S8E A;  3HVQ A;  3K7W C;  4ORB A;  4DSY A;  1T70 A;  3IVD A;  4H2I A;  1OID A;  4DHL A;  4OR9 A;  3QFN A;  3DSD A;  1QFC A;  1XZW A;  1FJM A;  4LAC C;  4FCX A;  3IB8 A;  5JPE A;  5JJT A;  3C5W C;  5J28 A;  3GVE A;  3EGG A;  4ZVZ A;  3IVE A;  4I5N C;  2JOG A;  4MP0 A;  1MF8 A;  2NXF A;  3DSC A;  2WDD A;  1S3N A;  2O8A A;  1JK7 A;  1OI8 A;  3P71 C;  1HPU A;  3H68 A;  1WAR A;  3H63 A;  4FBQ A;  3E7A A;  4ORA A;  2ZOA A;  2IE3 C;  1Z2X A;  4MOV A;  3THN A;  3THO B;  5JPF A;  2QJC A;  1G5B A;  4O5G A;  1KBP A;  2Z72 A;  4V0W A;  4FBW A;  4H2B A;  3D03 A;  2A22 A;  4V0X A;  3DW8 C;  1W24 A;  2WDF A;  4HD0 A;  2IE4 C;  2GJU A;  4MOY A;  4H1S A;  4KKZ A;  4UT2 A;  5DNY A;  3V4Y A;  4M0V A;  1U32 A;  2R17 A;  1T71 A;  4IYP C;  4H1Y P;  3K7V C;  1SU1 A;  3H66 A;  4I5L C;  2Q8U A;  3FLO A;  4YKE A;  1M63 A;  1USH A;  3IB7 A;  2Z06 A;  3ZTV A;  4TUI A;  2NYM C;  2ZO9 B;  4UT3 B;  3RL3 A;  3QFK A;  2BQ8 X;  4WWL A;  1WAO 1;  3H64 A;  3H62 B;  3KBP A;  3ZU0 A;  1OIE A;  2HYP A;  3C9F A;  3H69 A;  4H2F A;  1S70 A;  1HO5 A;  2WDC A;  3PSO A;  4V0V A;  1TCO A;  2Z1A A;  3E0J A;  5B8I A;  2QFR A;  3H61 A;  2NYL C;  1S95 A;  2AHD A;  3QFM A;  2BCD A;  2QFP A;  4TUG A;  4UWQ A;  2HYO A;  4KBP A;  1V73 A;  2KKN A;  3TGH A;  1UF3 A;  4O4K A;  5IOH A;  3H60 A;  1AUI A;  3H67 A;  5INB A;  4IL1 A;  2DXL A;  1QHW A;  2O8G A;  2YEQ A;  5C1V A;  3E7B A;  4FBK A;  1Z2W A;  4J6O A;  4LU9 A;  4O43 A;  3RL5 A;  4DT2 A;  3CK2 A;  4XPN A;  4G9J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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