The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
110
|
sequence length |
293
|
structure length |
293
|
Chain Sequence |
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
pubmed doi rcsb |
| molecule keywords |
Serine/threonine-protein phosphatase PP1-alpha catalytic sub
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
110
|
| structure length |
293
|
| sequence length |
293
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.1.3.16: Protein-serine/threonine phosphatase. |
| pdb deposition date | 2008-08-18 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00149 | Metallophos | Calcineurin-like phosphoesterase |
| A | PF16891 | STPPase_N | Serine-threonine protein phosphatase N-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 4-Layer Sandwich | Purple Acid Phosphatase; chain A, domain 2 | Purple Acid Phosphatase; chain A, domain 2 |
#chains in the Genus database with same CATH superfamily 1SU1 A; 1XZW A; 4UT3 A; 1HPU A; 2GJU A; 4H2G A; 3N5U A; 3RL5 A; 3ZTV A; 4DHL A; 3ZU0 A; 2O8G A; 4TUG A; 2NYL C; 3HVQ A; 2BQ8 X; 1FJM A; 3K7V C; 1OIE A; 3H63 A; 3AUZ A; 2NPP C; 4OR9 A; 1WAO 1; 1NNW A; 3KBP A; 2QFP A; 3H62 B; 3THN A; 1QFC A; 1MF8 A; 2R17 A; 1G5B A; 5INB A; 2HYO A; 4H2I A; 1M63 A; 2NXF A; 1UF3 A; 4H1S A; 5JPE A; 4HD0 A; 4I5L C; 4LTY A; 3DW8 C; 3DSD A; 3ICF A; 1IT6 A; 2HYP A; 3IVD A; 1II7 A; 1S8E A; 1Z2W A; 2IAE C; 1HO5 A; 1HP1 A; 4O43 A; 4V0W A; 5B8I A; 5J28 A; 1S95 A; 5JJT A; 4MOY A; 3FGA C; 3P71 C; 3EGG A; 2WDE A; 4I5N C; 4B2O A; 2NYM C; 1W24 A; 4F0Z A; 3GVE A; 3LL8 A; 2QFR A; 3H69 A; 2USH A; 4JA9 A; 2A22 A; 2KKN A; 1JK7 A; 5HPE A; 5F3W A; 2QJC A; 1Z2X A; 1OI8 A; 4H1Y P; 1QHW A; 2WDC A; 3T1I A; 3H67 A; 4IL1 A; 4M0V A; 2WDD A; 4LAC C; 3RQZ A; 4H2B A; 3C5W C; 5GTU A; 3QG5 C; 4FBK A; 1UTE A; 2CV9 A; 4IYP C; 1U32 A; 2P6B A; 3QFM A; 2XMO A; 1WAR A; 3DSC A; 5DNY A; 4KBP A; 3AV0 A; 3H60 A; 4ZX2 A; 2Z72 A; 1USH A; 3H66 A; 3QFO A; 5EQV A; 2Z1A A; 4XPN A; 2AHD A; 4FBQ A; 2HY1 A; 4ORA A; 1S3N A; 4ORB A; 1KBP A; 2DFJ A; 3THO B; 3QFK A; 2Z06 A; 3TGH A; 1XM7 A; 4FCX A; 3H68 A; 4TUI A; 4V0V A; 4UT2 A; 3CK2 A; 3IB7 A; 2O8A A; 2BDX A; 2IE3 C; 1T70 A; 5IOH A; 4KKZ A; 1V73 A; 2BCD A; 4MOV A; 3EGH A; 2IE4 C; 3QFN A; 1T71 A; 4ZVZ A; 4DT2 A; 4J6O A; 4YKE A; 2YVT A; 1AUI A; 3JYF A; 3RL4 A; 3V4Y A; 4FBW A; 4G9J A; 3PSO A; 3E7A A; 3H64 A; 4MP0 A; 4UWQ A; 1TCO A; 3K7W C; 3PSN A; 4O24 A; 3C9F A; 1OID A; 4WWL A; 1S70 A; 2JOG A; 2WDF A; 3IB8 A; 4ORC A; 3H61 A; 4UT3 B; 3RL3 A; 3IVE A; 5JPF A; 1S3M A; 5C1V A; 4NZV A; 3E7B A; 4JA7 A; 4O4K A; 4O5G A; 2Q8U A; 4Q7F A; 4V0X A; 4DSY A; 1S3L A; 4H2F A; 2ZBM A; 4LU9 A; #chains in the Genus database with same CATH topology 1SU1 A; 1XZW A; 4UT3 A; 1HPU A; 2GJU A; 4H2G A; 3N5U A; 3RL5 A; 3ZTV A; 4DHL A; 3ZU0 A; 2O8G A; 4TUG A; 3E0J A; 2NYL C; 3HVQ A; 2BQ8 X; 1FJM A; 3K7V C; 1OIE A; 3H63 A; 3AUZ A; 2NPP C; 4OR9 A; 1WAO 1; 1NNW A; 3KBP A; 2QFP A; 3H62 B; 3THN A; 1QFC A; 1MF8 A; 2R17 A; 1G5B A; 5INB A; 2HYO A; 4H2I A; 1M63 A; 2NXF A; 1UF3 A; 4H1S A; 5JPE A; 4HD0 A; 4I5L C; 4LTY A; 3DW8 C; 3DSD A; 3ICF A; 2ZO9 B; 1IT6 A; 2HYP A; 3IVD A; 1II7 A; 1S8E A; 1Z2W A; 2IAE C; 3D03 A; 1HO5 A; 1HP1 A; 4O43 A; 4V0W A; 5B8I A; 5J28 A; 1S95 A; 5JJT A; 4MOY A; 2DXN A; 3FGA C; 3P71 C; 3EGG A; 2WDE A; 4I5N C; 4B2O A; 2NYM C; 1W24 A; 4F0Z A; 3GVE A; 3LL8 A; 2QFR A; 3H69 A; 2USH A; 4JA9 A; 2A22 A; 2KKN A; 1JK7 A; 5HPE A; 5F3W A; 2QJC A; 1Z2X A; 1OI8 A; 4H1Y P; 1QHW A; 2WDC A; 3T1I A; 3H67 A; 4IL1 A; 4M0V A; 2WDD A; 4LAC C; 3RQZ A; 4H2B A; 3C5W C; 5GTU A; 3QG5 C; 4FBK A; 1UTE A; 2CV9 A; 4IYP C; 1U32 A; 2P6B A; 3QFM A; 2XMO A; 1WAR A; 3DSC A; 5DNY A; 4KBP A; 3AV0 A; 3H60 A; 4ZX2 A; 2Z72 A; 1USH A; 3H66 A; 3QFO A; 5EQV A; 2Z1A A; 2DXL A; 4XPN A; 3FLO A; 2AHD A; 4FBQ A; 2HY1 A; 4ORA A; 1S3N A; 4ORB A; 1KBP A; 2DFJ A; 3THO B; 3QFK A; 2Z06 A; 3TGH A; 1XM7 A; 4FCX A; 3H68 A; 4TUI A; 4V0V A; 4UT2 A; 3CK2 A; 3IB7 A; 2O8A A; 2BDX A; 2IE3 C; 1T70 A; 5IOH A; 4KKZ A; 1V73 A; 2BCD A; 4MOV A; 3EGH A; 2IE4 C; 3QFN A; 1T71 A; 4ZVZ A; 4DT2 A; 4J6O A; 4YKE A; 2YVT A; 1AUI A; 3JYF A; 3RL4 A; 3V4Y A; 4FBW A; 4G9J A; 3PSO A; 3E7A A; 3H64 A; 4MP0 A; 4UWQ A; 1TCO A; 3K7W C; 3PSN A; 4O24 A; 2YEQ A; 3C9F A; 1OID A; 4WWL A; 1S70 A; 2JOG A; 2WDF A; 3IB8 A; 4ORC A; 3H61 A; 4UT3 B; 3RL3 A; 3IVE A; 5JPF A; 2ZOA A; 1S3M A; 5C1V A; 4NZV A; 3E7B A; 4JA7 A; 4O4K A; 4O5G A; 2Q8U A; 4Q7F A; 4V0X A; 4DSY A; 1S3L A; 4H2F A; 2ZBM A; 4LU9 A; #chains in the Genus database with same CATH homology 1SU1 A; 1XZW A; 4UT3 A; 1HPU A; 2GJU A; 4H2G A; 3N5U A; 3RL5 A; 3ZTV A; 4DHL A; 3ZU0 A; 2O8G A; 4TUG A; 3E0J A; 2NYL C; 3HVQ A; 2BQ8 X; 1FJM A; 3K7V C; 1OIE A; 3H63 A; 3AUZ A; 2NPP C; 4OR9 A; 1WAO 1; 1NNW A; 3KBP A; 2QFP A; 3H62 B; 3THN A; 1QFC A; 1MF8 A; 2R17 A; 1G5B A; 5INB A; 2HYO A; 4H2I A; 1M63 A; 2NXF A; 1UF3 A; 4H1S A; 5JPE A; 4HD0 A; 4I5L C; 4LTY A; 3DW8 C; 3DSD A; 3ICF A; 2ZO9 B; 1IT6 A; 2HYP A; 3IVD A; 1II7 A; 1S8E A; 1Z2W A; 2IAE C; 3D03 A; 1HO5 A; 1HP1 A; 4O43 A; 4V0W A; 5B8I A; 5J28 A; 1S95 A; 5JJT A; 4MOY A; 2DXN A; 3FGA C; 3P71 C; 3EGG A; 2WDE A; 4I5N C; 4B2O A; 2NYM C; 1W24 A; 4F0Z A; 3GVE A; 3LL8 A; 2QFR A; 3H69 A; 2USH A; 4JA9 A; 2A22 A; 2KKN A; 1JK7 A; 5HPE A; 5F3W A; 2QJC A; 1Z2X A; 1OI8 A; 4H1Y P; 1QHW A; 2WDC A; 3T1I A; 3H67 A; 4IL1 A; 4M0V A; 2WDD A; 4LAC C; 3RQZ A; 4H2B A; 3C5W C; 5GTU A; 3QG5 C; 4FBK A; 1UTE A; 2CV9 A; 4IYP C; 1U32 A; 2P6B A; 3QFM A; 2XMO A; 1WAR A; 3DSC A; 5DNY A; 4KBP A; 3AV0 A; 3H60 A; 4ZX2 A; 2Z72 A; 1USH A; 3H66 A; 3QFO A; 5EQV A; 2Z1A A; 2DXL A; 4XPN A; 3FLO A; 2AHD A; 4FBQ A; 2HY1 A; 4ORA A; 1S3N A; 4ORB A; 1KBP A; 2DFJ A; 3THO B; 3QFK A; 2Z06 A; 3TGH A; 1XM7 A; 4FCX A; 3H68 A; 4TUI A; 4V0V A; 4UT2 A; 3CK2 A; 3IB7 A; 2O8A A; 2BDX A; 2IE3 C; 1T70 A; 5IOH A; 4KKZ A; 1V73 A; 2BCD A; 4MOV A; 3EGH A; 2IE4 C; 3QFN A; 1T71 A; 4ZVZ A; 4DT2 A; 4J6O A; 4YKE A; 2YVT A; 1AUI A; 3JYF A; 3RL4 A; 3V4Y A; 4FBW A; 4G9J A; 3PSO A; 3E7A A; 3H64 A; 4MP0 A; 4UWQ A; 1TCO A; 3K7W C; 3PSN A; 4O24 A; 2YEQ A; 3C9F A; 1OID A; 4WWL A; 1S70 A; 2JOG A; 2WDF A; 3IB8 A; 4ORC A; 3H61 A; 4UT3 B; 3RL3 A; 3IVE A; 5JPF A; 2ZOA A; 1S3M A; 5C1V A; 4NZV A; 3E7B A; 4JA7 A; 4O4K A; 4O5G A; 2Q8U A; 4Q7F A; 4V0X A; 4DSY A; 1S3L A; 4H2F A; 2ZBM A; 4LU9 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
