3EGGA

Crystal structure of a complex between protein phosphatase 1 alpha (pp1) and the pp1 binding and pdz domains of spinophilin
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
294
structure length
294
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 112
structure length 294
sequence length 294
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3eggA00
4KKZA 4H2FA 3JYFA 4IL1A 1II7A 2A22A 3N5UA 2WDDA 3EGGA 1KBPA 2GJUA 3IB7A 3QFKA 1OI8A 4UT3A 1S3NA 2NXFA 4IYPC 1WAO1 5EQVA 3PSOA 4FBKA 4ORAA 1AUIA 2JOGA 3RL5A 3IB8A 3ZU0A 1OIDA 2WDFA 3ICFA 2HYOA 3P71C 5J28A 3ZTVA 1S95A 4F0ZA 3C9FA 3H63A 2BCDA 3DSCA 3EGHA 3E7AA 5INBA 2IE4C 1HO5A 3E7BA 4ORCA 3RQZA 3IVEA 4Q7FA 2BDXA 2IAEC 1JK7A 4H2IA 4B2OA 3CK2A 1S3MA 2O8AA 4M0VA 5DNYA 4TUIA 3GVEA 2HYPA 3THOB 4ORBA 1QFCA 1Z2XA 2YVTA 3T1IA 1Z2WA 4YKEA 1W24A 3AV0A 4DHLA 3LL8A 3RL3A 1QHWA 2Z06A 1T71A 2DFJA 2XMOA 2Z1AA 4MOVA 4WWLA 2KKNA 3H64A 4LTYA 3C5WC 4O5GA 5JJTA 3H62B 4LACC 4V0XA 4LU9A 4UT3B 4V0VA 2BQ8X 3K7VC 3K7WC 4DT2A 4DSYA 2NYMC 2Z72A 4G9JA 4ZVZA 4FBQA 4O43A 2Q8UA 3V4YA 2NYLC 5JPEA 2QFPA 1FJMA 1USHA 5GTUA 4FCXA 1HP1A 4OR9A 3THNA 4H2GA 3DSDA 2WDCA 4ZX2A 4H1SA 1TCOA 4O4KA 1HPUA 3KBPA 5JPFA 3DW8C 3H61A 3QFMA 2IE3C 1IT6A 4I5NC 4MP0A 2QJCA 1S3LA 4UWQA 4J6OA 4MOYA 2ZBMA 1UF3A 3QG5C 1XM7A 3H67A 2R17A 3QFOA 3TGHA 2P6BA 1G5BA 5HPEA 2NPPC 4JA7A 3H66A 1U32A 4JA9A 1OIEA 1M63A 4I5LC 2AHDA 1NNWA 3H60A 2USHA 4XPNA 4FBWA 5C1VA 2QFRA 4KBPA 3FGAC 5B8IA 4H1YP 3RL4A 3H68A 1T70A 2O8GA 3H69A 1S70A 1XZWA 4UT2A 3PSNA 2WDEA 5F3WA 4H2BA 3QFNA 1S8EA 1UTEA 2CV9A 1SU1A 1MF8A 2HY1A 3AUZA 4O24A 4V0WA 1WARA 1V73A 3HVQA 4HD0A 4NZVA 5IOHA 4TUGA 3IVDA
chains in the Genus database with same CATH superfamily
4KKZA 4H2FA 3JYFA 4IL1A 2ZOAA 1II7A 2A22A 3N5UA 2WDDA 3EGGA 1KBPA 2GJUA 3IB7A 3QFKA 1OI8A 4UT3A 1S3NA 2NXFA 4IYPC 1WAO1 5EQVA 3PSOA 4FBKA 4ORAA 1AUIA 2JOGA 3RL5A 3IB8A 3ZU0A 1OIDA 2WDFA 3ICFA 2HYOA 3P71C 5J28A 3ZTVA 1S95A 4F0ZA 3C9FA 3H63A 3D03A 2BCDA 3DSCA 3EGHA 3E7AA 5INBA 2IE4C 1HO5A 3E7BA 4ORCA 3RQZA 3IVEA 4Q7FA 2BDXA 2IAEC 1JK7A 4H2IA 4B2OA 3CK2A 2YEQA 1S3MA 2O8AA 4M0VA 5DNYA 4TUIA 3GVEA 2HYPA 3THOB 4ORBA 1QFCA 1Z2XA 2YVTA 3T1IA 1Z2WA 4YKEA 1W24A 3AV0A 4DHLA 3LL8A 3RL3A 1QHWA 2Z06A 1T71A 2DFJA 2XMOA 2Z1AA 4MOVA 4WWLA 2KKNA 3H64A 4LTYA 3C5WC 4O5GA 5JJTA 3H62B 4LACC 4V0XA 4LU9A 4UT3B 4V0VA 2BQ8X 3K7VC 3K7WC 4DT2A 4DSYA 2NYMC 2Z72A 4G9JA 4ZVZA 4FBQA 4O43A 2Q8UA 3V4YA 2NYLC 5JPEA 2QFPA 1FJMA 1USHA 5GTUA 4FCXA 1HP1A 4OR9A 3THNA 4H2GA 3DSDA 2WDCA 4ZX2A 4H1SA 1TCOA 4O4KA 1HPUA 3FLOA 3KBPA 5JPFA 3DW8C 3H61A 3QFMA 2IE3C 1IT6A 4I5NC 4MP0A 2QJCA 2DXNA 2DXLA 2ZO9B 1S3LA 3E0JA 4J6OA 4UWQA 4MOYA 2ZBMA 1UF3A 3QG5C 1XM7A 3H67A 2R17A 3QFOA 3TGHA 2P6BA 1G5BA 5HPEA 2NPPC 4JA7A 3H66A 1U32A 4JA9A 1OIEA 1M63A 4I5LC 2AHDA 1NNWA 3H60A 2USHA 4XPNA 4FBWA 5C1VA 2QFRA 4KBPA 3FGAC 5B8IA 4H1YP 3RL4A 3H68A 1T70A 2O8GA 3H69A 1S70A 1XZWA 4UT2A 3PSNA 2WDEA 5F3WA 4H2BA 3QFNA 1S8EA 1UTEA 2CV9A 1SU1A 1MF8A 2HY1A 3AUZA 4O24A 4V0WA 1WARA 1V73A 3HVQA 4HD0A 4NZVA 5IOHA 4TUGA 3IVDA
chains in the Genus database with same CATH topology
4KKZA 4H2FA 3JYFA 4IL1A 2ZOAA 1II7A 2A22A 3N5UA 2WDDA 3EGGA 1KBPA 2GJUA 3IB7A 3QFKA 1OI8A 4UT3A 1S3NA 2NXFA 4IYPC 1WAO1 5EQVA 3PSOA 4FBKA 4ORAA 1AUIA 2JOGA 3RL5A 3IB8A 3ZU0A 1OIDA 2WDFA 3ICFA 2HYOA 3P71C 5J28A 3ZTVA 1S95A 4F0ZA 3C9FA 3H63A 3D03A 2BCDA 3DSCA 3EGHA 3E7AA 5INBA 2IE4C 1HO5A 3E7BA 4ORCA 3RQZA 3IVEA 4Q7FA 2BDXA 2IAEC 1JK7A 4H2IA 4B2OA 3CK2A 2YEQA 1S3MA 2O8AA 4M0VA 5DNYA 4TUIA 3GVEA 2HYPA 3THOB 4ORBA 1QFCA 1Z2XA 2YVTA 3T1IA 1Z2WA 4YKEA 1W24A 3AV0A 4DHLA 3LL8A 3RL3A 1QHWA 2Z06A 1T71A 2DFJA 2XMOA 2Z1AA 4MOVA 4WWLA 2KKNA 3H64A 4LTYA 3C5WC 4O5GA 5JJTA 3H62B 4LACC 4V0XA 4LU9A 4UT3B 4V0VA 2BQ8X 3K7VC 3K7WC 4DT2A 4DSYA 2NYMC 2Z72A 4G9JA 4ZVZA 4FBQA 4O43A 2Q8UA 3V4YA 2NYLC 5JPEA 2QFPA 1FJMA 1USHA 5GTUA 4FCXA 1HP1A 4OR9A 3THNA 4H2GA 3DSDA 2WDCA 4ZX2A 4H1SA 1TCOA 4O4KA 1HPUA 3FLOA 3KBPA 5JPFA 3DW8C 3H61A 3QFMA 2IE3C 1IT6A 4I5NC 4MP0A 2QJCA 2DXNA 2DXLA 2ZO9B 1S3LA 3E0JA 4J6OA 4UWQA 4MOYA 2ZBMA 1UF3A 3QG5C 1XM7A 3H67A 2R17A 3QFOA 3TGHA 2P6BA 1G5BA 5HPEA 2NPPC 4JA7A 3H66A 1U32A 4JA9A 1OIEA 1M63A 4I5LC 2AHDA 1NNWA 3H60A 2USHA 4XPNA 4FBWA 5C1VA 2QFRA 4KBPA 3FGAC 5B8IA 4H1YP 3RL4A 3H68A 1T70A 2O8GA 3H69A 1S70A 1XZWA 4UT2A 3PSNA 2WDEA 5F3WA 4H2BA 3QFNA 1S8EA 1UTEA 2CV9A 1SU1A 1MF8A 2HY1A 3AUZA 4O24A 4V0WA 1WARA 1V73A 3HVQA 4HD0A 4NZVA 5IOHA 4TUGA 3IVDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KKZ A;  4H2F A;  3JYF A;  4IL1 A;  1II7 A;  2A22 A;  3N5U A;  2WDD A;  3EGG A;  1KBP A;  2GJU A;  3IB7 A;  3QFK A;  1OI8 A;  4UT3 A;  1S3N A;  2NXF A;  4IYP C;  1WAO 1;  5EQV A;  3PSO A;  4FBK A;  4ORA A;  1AUI A;  2JOG A;  3RL5 A;  3IB8 A;  3ZU0 A;  1OID A;  2WDF A;  3ICF A;  2HYO A;  3P71 C;  5J28 A;  3ZTV A;  1S95 A;  4F0Z A;  3C9F A;  3H63 A;  2BCD A;  3DSC A;  3EGH A;  3E7A A;  5INB A;  2IE4 C;  1HO5 A;  3E7B A;  4ORC A;  3RQZ A;  3IVE A;  4Q7F A;  2BDX A;  2IAE C;  1JK7 A;  4H2I A;  4B2O A;  3CK2 A;  1S3M A;  2O8A A;  4M0V A;  5DNY A;  4TUI A;  3GVE A;  2HYP A;  3THO B;  4ORB A;  1QFC A;  1Z2X A;  2YVT A;  3T1I A;  1Z2W A;  4YKE A;  1W24 A;  3AV0 A;  4DHL A;  3LL8 A;  3RL3 A;  1QHW A;  2Z06 A;  1T71 A;  2DFJ A;  2XMO A;  2Z1A A;  4MOV A;  4WWL A;  2KKN A;  3H64 A;  4LTY A;  3C5W C;  4O5G A;  5JJT A;  3H62 B;  4LAC C;  4V0X A;  4LU9 A;  4UT3 B;  4V0V A;  2BQ8 X;  3K7V C;  3K7W C;  4DT2 A;  4DSY A;  2NYM C;  2Z72 A;  4G9J A;  4ZVZ A;  4FBQ A;  4O43 A;  2Q8U A;  3V4Y A;  2NYL C;  5JPE A;  2QFP A;  1FJM A;  1USH A;  5GTU A;  4FCX A;  1HP1 A;  4OR9 A;  3THN A;  4H2G A;  3DSD A;  2WDC A;  4ZX2 A;  4H1S A;  1TCO A;  4O4K A;  1HPU A;  3KBP A;  5JPF A;  3DW8 C;  3H61 A;  3QFM A;  2IE3 C;  1IT6 A;  4I5N C;  4MP0 A;  2QJC A;  1S3L A;  4UWQ A;  4J6O A;  4MOY A;  2ZBM A;  1UF3 A;  3QG5 C;  1XM7 A;  3H67 A;  2R17 A;  3QFO A;  3TGH A;  2P6B A;  1G5B A;  5HPE A;  2NPP C;  4JA7 A;  3H66 A;  1U32 A;  4JA9 A;  1OIE A;  1M63 A;  4I5L C;  2AHD A;  1NNW A;  3H60 A;  2USH A;  4XPN A;  4FBW A;  5C1V A;  2QFR A;  4KBP A;  3FGA C;  5B8I A;  4H1Y P;  3RL4 A;  3H68 A;  1T70 A;  2O8G A;  3H69 A;  1S70 A;  1XZW A;  4UT2 A;  3PSN A;  2WDE A;  5F3W A;  4H2B A;  3QFN A;  1S8E A;  1UTE A;  2CV9 A;  1SU1 A;  1MF8 A;  2HY1 A;  3AUZ A;  4O24 A;  4V0W A;  1WAR A;  1V73 A;  3HVQ A;  4HD0 A;  4NZV A;  5IOH A;  4TUG A;  3IVD A; 
#chains in the Genus database with same CATH topology
 4KKZ A;  4H2F A;  3JYF A;  4IL1 A;  2ZOA A;  1II7 A;  2A22 A;  3N5U A;  2WDD A;  3EGG A;  1KBP A;  2GJU A;  3IB7 A;  3QFK A;  1OI8 A;  4UT3 A;  1S3N A;  2NXF A;  4IYP C;  1WAO 1;  5EQV A;  3PSO A;  4FBK A;  4ORA A;  1AUI A;  2JOG A;  3RL5 A;  3IB8 A;  3ZU0 A;  1OID A;  2WDF A;  3ICF A;  2HYO A;  3P71 C;  5J28 A;  3ZTV A;  1S95 A;  4F0Z A;  3C9F A;  3H63 A;  3D03 A;  2BCD A;  3DSC A;  3EGH A;  3E7A A;  5INB A;  2IE4 C;  1HO5 A;  3E7B A;  4ORC A;  3RQZ A;  3IVE A;  4Q7F A;  2BDX A;  2IAE C;  1JK7 A;  4H2I A;  4B2O A;  3CK2 A;  2YEQ A;  1S3M A;  2O8A A;  4M0V A;  5DNY A;  4TUI A;  3GVE A;  2HYP A;  3THO B;  4ORB A;  1QFC A;  1Z2X A;  2YVT A;  3T1I A;  1Z2W A;  4YKE A;  1W24 A;  3AV0 A;  4DHL A;  3LL8 A;  3RL3 A;  1QHW A;  2Z06 A;  1T71 A;  2DFJ A;  2XMO A;  2Z1A A;  4MOV A;  4WWL A;  2KKN A;  3H64 A;  4LTY A;  3C5W C;  4O5G A;  5JJT A;  3H62 B;  4LAC C;  4V0X A;  4LU9 A;  4UT3 B;  4V0V A;  2BQ8 X;  3K7V C;  3K7W C;  4DT2 A;  4DSY A;  2NYM C;  2Z72 A;  4G9J A;  4ZVZ A;  4FBQ A;  4O43 A;  2Q8U A;  3V4Y A;  2NYL C;  5JPE A;  2QFP A;  1FJM A;  1USH A;  5GTU A;  4FCX A;  1HP1 A;  4OR9 A;  3THN A;  4H2G A;  3DSD A;  2WDC A;  4ZX2 A;  4H1S A;  1TCO A;  4O4K A;  1HPU A;  3FLO A;  3KBP A;  5JPF A;  3DW8 C;  3H61 A;  3QFM A;  2IE3 C;  1IT6 A;  4I5N C;  4MP0 A;  2QJC A;  2DXN A;  2DXL A;  2ZO9 B;  1S3L A;  3E0J A;  4J6O A;  4UWQ A;  4MOY A;  2ZBM A;  1UF3 A;  3QG5 C;  1XM7 A;  3H67 A;  2R17 A;  3QFO A;  3TGH A;  2P6B A;  1G5B A;  5HPE A;  2NPP C;  4JA7 A;  3H66 A;  1U32 A;  4JA9 A;  1OIE A;  1M63 A;  4I5L C;  2AHD A;  1NNW A;  3H60 A;  2USH A;  4XPN A;  4FBW A;  5C1V A;  2QFR A;  4KBP A;  3FGA C;  5B8I A;  4H1Y P;  3RL4 A;  3H68 A;  1T70 A;  2O8G A;  3H69 A;  1S70 A;  1XZW A;  4UT2 A;  3PSN A;  2WDE A;  5F3W A;  4H2B A;  3QFN A;  1S8E A;  1UTE A;  2CV9 A;  1SU1 A;  1MF8 A;  2HY1 A;  3AUZ A;  4O24 A;  4V0W A;  1WAR A;  1V73 A;  3HVQ A;  4HD0 A;  4NZV A;  5IOH A;  4TUG A;  3IVD A; 
#chains in the Genus database with same CATH homology
 4KKZ A;  4H2F A;  3JYF A;  4IL1 A;  2ZOA A;  1II7 A;  2A22 A;  3N5U A;  2WDD A;  3EGG A;  1KBP A;  2GJU A;  3IB7 A;  3QFK A;  1OI8 A;  4UT3 A;  1S3N A;  2NXF A;  4IYP C;  1WAO 1;  5EQV A;  3PSO A;  4FBK A;  4ORA A;  1AUI A;  2JOG A;  3RL5 A;  3IB8 A;  3ZU0 A;  1OID A;  2WDF A;  3ICF A;  2HYO A;  3P71 C;  5J28 A;  3ZTV A;  1S95 A;  4F0Z A;  3C9F A;  3H63 A;  3D03 A;  2BCD A;  3DSC A;  3EGH A;  3E7A A;  5INB A;  2IE4 C;  1HO5 A;  3E7B A;  4ORC A;  3RQZ A;  3IVE A;  4Q7F A;  2BDX A;  2IAE C;  1JK7 A;  4H2I A;  4B2O A;  3CK2 A;  2YEQ A;  1S3M A;  2O8A A;  4M0V A;  5DNY A;  4TUI A;  3GVE A;  2HYP A;  3THO B;  4ORB A;  1QFC A;  1Z2X A;  2YVT A;  3T1I A;  1Z2W A;  4YKE A;  1W24 A;  3AV0 A;  4DHL A;  3LL8 A;  3RL3 A;  1QHW A;  2Z06 A;  1T71 A;  2DFJ A;  2XMO A;  2Z1A A;  4MOV A;  4WWL A;  2KKN A;  3H64 A;  4LTY A;  3C5W C;  4O5G A;  5JJT A;  3H62 B;  4LAC C;  4V0X A;  4LU9 A;  4UT3 B;  4V0V A;  2BQ8 X;  3K7V C;  3K7W C;  4DT2 A;  4DSY A;  2NYM C;  2Z72 A;  4G9J A;  4ZVZ A;  4FBQ A;  4O43 A;  2Q8U A;  3V4Y A;  2NYL C;  5JPE A;  2QFP A;  1FJM A;  1USH A;  5GTU A;  4FCX A;  1HP1 A;  4OR9 A;  3THN A;  4H2G A;  3DSD A;  2WDC A;  4ZX2 A;  4H1S A;  1TCO A;  4O4K A;  1HPU A;  3FLO A;  3KBP A;  5JPF A;  3DW8 C;  3H61 A;  3QFM A;  2IE3 C;  1IT6 A;  4I5N C;  4MP0 A;  2QJC A;  2DXN A;  2DXL A;  2ZO9 B;  1S3L A;  3E0J A;  4J6O A;  4UWQ A;  4MOY A;  2ZBM A;  1UF3 A;  3QG5 C;  1XM7 A;  3H67 A;  2R17 A;  3QFO A;  3TGH A;  2P6B A;  1G5B A;  5HPE A;  2NPP C;  4JA7 A;  3H66 A;  1U32 A;  4JA9 A;  1OIE A;  1M63 A;  4I5L C;  2AHD A;  1NNW A;  3H60 A;  2USH A;  4XPN A;  4FBW A;  5C1V A;  2QFR A;  4KBP A;  3FGA C;  5B8I A;  4H1Y P;  3RL4 A;  3H68 A;  1T70 A;  2O8G A;  3H69 A;  1S70 A;  1XZW A;  4UT2 A;  3PSN A;  2WDE A;  5F3W A;  4H2B A;  3QFN A;  1S8E A;  1UTE A;  2CV9 A;  1SU1 A;  1MF8 A;  2HY1 A;  3AUZ A;  4O24 A;  4V0W A;  1WAR A;  1V73 A;  3HVQ A;  4HD0 A;  4NZV A;  5IOH A;  4TUG A;  3IVD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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