3EGHA

Crystal structure of a complex between protein phosphatase 1 alpha (pp1), the pp1 binding and pdz domains of spinophilin and the small natural molecular toxin nodularin-r
Total Genus 107
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
294
structure length
294
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 107
structure length 294
sequence length 294
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3eghA00
4LU9A 4FBKA 2QFPA 3PSNA 3EGGA 1WARA 3KBPA 3THOB 4UT3B 3DSDA 2Z72A 1NNWA 4UT3A 4B2OA 2P6BA 1KBPA 4IYPC 4UWQA 3RL3A 4H1SA 4KBPA 1UF3A 5JJTA 2QJCA 4ZX2A 1TCOA 1S3LA 4TUGA 1II7A 4UT2A 2BCDA 3C9FA 3E7BA 3DW8C 5GTUA 2NYLC 3QFOA 4G9JA 5HPEA 1T70A 2A22A 4FBWA 1OI8A 1JK7A 3H61A 4Q7FA 3DSCA 1UTEA 3QG5C 3IVDA 1Z2WA 1S3NA 3EGHA 1Z2XA 3IB7A 3P71C 1HPUA 2XMOA 3C5WC 3E7AA 1M63A 1XM7A 3IB8A 1V73A 3THNA 3V4YA 3N5UA 4DHLA 4DT2A 5C1VA 3QFMA 4HD0A 3LL8A 1S95A 1WAO1 1MF8A 3H64A 4I5LC 4H2BA 3H62B 4ZVZA 2NPPC 5EQVA 2WDFA 2Q8UA 4J6OA 2YVTA 2BDXA 2DFJA 4V0WA 1S8EA 2O8AA 4O4KA 1G5BA 4MOVA 2CV9A 4O5GA 2R17A 4H2IA 5INBA 3QFKA 4FCXA 4LTYA 3H69A 4OR9A 4O43A 1XZWA 2WDDA 4V0XA 1SU1A 4DSYA 1S70A 1OIEA 2QFRA 3H60A 3JYFA 4JA9A 2ZBMA 4ORCA 4MP0A 3K7VC 4O24A 4XPNA 4H2FA 1W24A 1IT6A 1HO5A 4H1YP 1AUIA 4IL1A 3RL4A 1OIDA 4M0VA 3GVEA 3TGHA 2IE3C 2NYMC 3ZU0A 2IAEC 4ORBA 3ZTVA 3PSOA 2WDCA 3QFNA 4FBQA 3CK2A 1QHWA 4ORAA 4KKZA 3H66A 4H2GA 4TUIA 4YKEA 2Z06A 2GJUA 5IOHA 2O8GA 4F0ZA 3FGAC 5JPEA 2HYPA 4MOYA 3RL5A 3RQZA 1T71A 3AUZA 2AHDA 3IVEA 3AV0A 2KKNA 2USHA 3H68A 3T1IA 3ICFA 1USHA 1FJMA 1S3MA 1U32A 2WDEA 3HVQA 5B8IA 4JA7A 2BQ8X 5JPFA 4WWLA 1HP1A 3H63A 5DNYA 3H67A 2IE4C 4V0VA 4LACC 2JOGA 1QFCA 3K7WC 5J28A 4NZVA 2NXFA 2HY1A 2HYOA 2Z1AA 4I5NC 5F3WA
chains in the Genus database with same CATH superfamily
4LU9A 4FBKA 2QFPA 3PSNA 3EGGA 1WARA 3KBPA 3THOB 4UT3B 3DSDA 2Z72A 1NNWA 2ZOAA 4UT3A 4B2OA 2P6BA 1KBPA 4IYPC 4UWQA 3RL3A 4H1SA 4KBPA 1UF3A 5JJTA 2QJCA 4ZX2A 1TCOA 1S3LA 4TUGA 2DXNA 1II7A 4UT2A 2BCDA 3C9FA 3E7BA 3DW8C 5GTUA 2NYLC 3QFOA 4G9JA 5HPEA 1T70A 2A22A 4FBWA 1OI8A 1JK7A 3H61A 4Q7FA 3DSCA 1UTEA 3QG5C 3IVDA 1Z2WA 1S3NA 3EGHA 1Z2XA 3IB7A 3P71C 1HPUA 2XMOA 3C5WC 3E7AA 1M63A 1XM7A 3IB8A 1V73A 3THNA 3V4YA 3N5UA 4DHLA 4DT2A 5C1VA 3QFMA 4HD0A 3LL8A 1S95A 1WAO1 1MF8A 3H64A 4I5LC 4H2BA 3H62B 4ZVZA 2NPPC 5EQVA 2WDFA 2Q8UA 4J6OA 2YVTA 2BDXA 2DFJA 4V0WA 1S8EA 2O8AA 4O4KA 1G5BA 4MOVA 2CV9A 4O5GA 2R17A 4H2IA 5INBA 3QFKA 4FCXA 4LTYA 3H69A 4OR9A 4O43A 1XZWA 2WDDA 4V0XA 1SU1A 4DSYA 1S70A 1OIEA 2QFRA 3H60A 3JYFA 4JA9A 2ZBMA 4ORCA 4MP0A 3K7VC 4O24A 2DXLA 4H2FA 4XPNA 1W24A 1IT6A 1HO5A 4H1YP 1AUIA 4IL1A 3RL4A 1OIDA 4M0VA 3GVEA 3TGHA 2IE3C 2NYMC 3ZU0A 2IAEC 4ORBA 3ZTVA 3PSOA 2WDCA 3QFNA 4FBQA 3CK2A 1QHWA 4ORAA 4KKZA 3H66A 4H2GA 4TUIA 4YKEA 2Z06A 2GJUA 5IOHA 2O8GA 4F0ZA 3FGAC 5JPEA 2HYPA 4MOYA 3RL5A 3RQZA 1T71A 3AUZA 2AHDA 3IVEA 2YEQA 3AV0A 2KKNA 2USHA 3H68A 3T1IA 3D03A 3ICFA 2ZO9B 1USHA 1FJMA 1S3MA 1U32A 2WDEA 3HVQA 5B8IA 4JA7A 2BQ8X 5JPFA 3FLOA 4WWLA 1HP1A 3H63A 5DNYA 3H67A 2IE4C 4V0VA 4LACC 2JOGA 1QFCA 3K7WC 5J28A 4NZVA 2NXFA 2HY1A 2HYOA 2Z1AA 3E0JA 4I5NC 5F3WA
chains in the Genus database with same CATH topology
4LU9A 4FBKA 2QFPA 3PSNA 3EGGA 1WARA 3KBPA 3THOB 4UT3B 3DSDA 2Z72A 1NNWA 2ZOAA 4UT3A 4B2OA 2P6BA 1KBPA 4IYPC 4UWQA 3RL3A 4H1SA 4KBPA 1UF3A 5JJTA 2QJCA 4ZX2A 1TCOA 1S3LA 4TUGA 2DXNA 1II7A 4UT2A 2BCDA 3C9FA 3E7BA 3DW8C 5GTUA 2NYLC 3QFOA 4G9JA 5HPEA 1T70A 2A22A 4FBWA 1OI8A 1JK7A 3H61A 4Q7FA 3DSCA 1UTEA 3QG5C 3IVDA 1Z2WA 1S3NA 3EGHA 1Z2XA 3IB7A 3P71C 1HPUA 2XMOA 3C5WC 3E7AA 1M63A 1XM7A 3IB8A 1V73A 3THNA 3V4YA 3N5UA 4DHLA 4DT2A 5C1VA 3QFMA 4HD0A 3LL8A 1S95A 1WAO1 1MF8A 3H64A 4I5LC 4H2BA 3H62B 4ZVZA 2NPPC 5EQVA 2WDFA 2Q8UA 4J6OA 2YVTA 2BDXA 2DFJA 4V0WA 1S8EA 2O8AA 4O4KA 1G5BA 4MOVA 2CV9A 4O5GA 2R17A 4H2IA 5INBA 3QFKA 4FCXA 4LTYA 3H69A 4OR9A 4O43A 1XZWA 2WDDA 4V0XA 1SU1A 4DSYA 1S70A 1OIEA 2QFRA 3H60A 3JYFA 4JA9A 2ZBMA 4ORCA 4MP0A 3K7VC 4O24A 2DXLA 4H2FA 4XPNA 1W24A 1IT6A 1HO5A 4H1YP 1AUIA 4IL1A 3RL4A 1OIDA 4M0VA 3GVEA 3TGHA 2IE3C 2NYMC 3ZU0A 2IAEC 4ORBA 3ZTVA 3PSOA 2WDCA 3QFNA 4FBQA 3CK2A 1QHWA 4ORAA 4KKZA 3H66A 4H2GA 4TUIA 4YKEA 2Z06A 2GJUA 5IOHA 2O8GA 4F0ZA 3FGAC 5JPEA 2HYPA 4MOYA 3RL5A 3RQZA 1T71A 3AUZA 2AHDA 3IVEA 2YEQA 3AV0A 2KKNA 2USHA 3H68A 3T1IA 3D03A 3ICFA 2ZO9B 1USHA 1FJMA 1S3MA 1U32A 2WDEA 3HVQA 5B8IA 4JA7A 2BQ8X 5JPFA 3FLOA 4WWLA 1HP1A 3H63A 5DNYA 3H67A 2IE4C 4V0VA 4LACC 2JOGA 1QFCA 3K7WC 5J28A 4NZVA 2NXFA 2HY1A 2HYOA 2Z1AA 3E0JA 4I5NC 5F3WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LU9 A;  4FBK A;  2QFP A;  3PSN A;  3EGG A;  1WAR A;  3KBP A;  3THO B;  4UT3 B;  3DSD A;  2Z72 A;  1NNW A;  4UT3 A;  4B2O A;  2P6B A;  1KBP A;  4IYP C;  4UWQ A;  3RL3 A;  4H1S A;  4KBP A;  1UF3 A;  5JJT A;  2QJC A;  4ZX2 A;  1TCO A;  1S3L A;  4TUG A;  1II7 A;  4UT2 A;  2BCD A;  3C9F A;  3E7B A;  3DW8 C;  5GTU A;  2NYL C;  3QFO A;  4G9J A;  5HPE A;  1T70 A;  2A22 A;  4FBW A;  1OI8 A;  1JK7 A;  3H61 A;  4Q7F A;  3DSC A;  1UTE A;  3QG5 C;  3IVD A;  1Z2W A;  1S3N A;  3EGH A;  1Z2X A;  3IB7 A;  3P71 C;  1HPU A;  2XMO A;  3C5W C;  3E7A A;  1M63 A;  1XM7 A;  3IB8 A;  1V73 A;  3THN A;  3V4Y A;  3N5U A;  4DHL A;  4DT2 A;  5C1V A;  3QFM A;  4HD0 A;  3LL8 A;  1S95 A;  1WAO 1;  1MF8 A;  3H64 A;  4I5L C;  4H2B A;  3H62 B;  4ZVZ A;  2NPP C;  5EQV A;  2WDF A;  2Q8U A;  4J6O A;  2YVT A;  2BDX A;  2DFJ A;  4V0W A;  1S8E A;  2O8A A;  4O4K A;  1G5B A;  4MOV A;  2CV9 A;  4O5G A;  2R17 A;  4H2I A;  5INB A;  3QFK A;  4FCX A;  4LTY A;  3H69 A;  4OR9 A;  4O43 A;  1XZW A;  2WDD A;  4V0X A;  1SU1 A;  4DSY A;  1S70 A;  1OIE A;  2QFR A;  3H60 A;  3JYF A;  4JA9 A;  2ZBM A;  4ORC A;  4MP0 A;  3K7V C;  4O24 A;  4XPN A;  4H2F A;  1W24 A;  1IT6 A;  1HO5 A;  4H1Y P;  1AUI A;  4IL1 A;  3RL4 A;  1OID A;  4M0V A;  3GVE A;  3TGH A;  2IE3 C;  2NYM C;  3ZU0 A;  2IAE C;  4ORB A;  3ZTV A;  3PSO A;  2WDC A;  3QFN A;  4FBQ A;  3CK2 A;  1QHW A;  4ORA A;  4KKZ A;  3H66 A;  4H2G A;  4TUI A;  4YKE A;  2Z06 A;  2GJU A;  5IOH A;  2O8G A;  4F0Z A;  3FGA C;  5JPE A;  2HYP A;  4MOY A;  3RL5 A;  3RQZ A;  1T71 A;  3AUZ A;  2AHD A;  3IVE A;  3AV0 A;  2KKN A;  2USH A;  3H68 A;  3T1I A;  3ICF A;  1USH A;  1FJM A;  1S3M A;  1U32 A;  2WDE A;  3HVQ A;  5B8I A;  4JA7 A;  2BQ8 X;  5JPF A;  4WWL A;  1HP1 A;  3H63 A;  5DNY A;  3H67 A;  2IE4 C;  4V0V A;  4LAC C;  2JOG A;  1QFC A;  3K7W C;  5J28 A;  4NZV A;  2NXF A;  2HY1 A;  2HYO A;  2Z1A A;  4I5N C;  5F3W A; 
#chains in the Genus database with same CATH topology
 4LU9 A;  4FBK A;  2QFP A;  3PSN A;  3EGG A;  1WAR A;  3KBP A;  3THO B;  4UT3 B;  3DSD A;  2Z72 A;  1NNW A;  2ZOA A;  4UT3 A;  4B2O A;  2P6B A;  1KBP A;  4IYP C;  4UWQ A;  3RL3 A;  4H1S A;  4KBP A;  1UF3 A;  5JJT A;  2QJC A;  4ZX2 A;  1TCO A;  1S3L A;  4TUG A;  2DXN A;  1II7 A;  4UT2 A;  2BCD A;  3C9F A;  3E7B A;  3DW8 C;  5GTU A;  2NYL C;  3QFO A;  4G9J A;  5HPE A;  1T70 A;  2A22 A;  4FBW A;  1OI8 A;  1JK7 A;  3H61 A;  4Q7F A;  3DSC A;  1UTE A;  3QG5 C;  3IVD A;  1Z2W A;  1S3N A;  3EGH A;  1Z2X A;  3IB7 A;  3P71 C;  1HPU A;  2XMO A;  3C5W C;  3E7A A;  1M63 A;  1XM7 A;  3IB8 A;  1V73 A;  3THN A;  3V4Y A;  3N5U A;  4DHL A;  4DT2 A;  5C1V A;  3QFM A;  4HD0 A;  3LL8 A;  1S95 A;  1WAO 1;  1MF8 A;  3H64 A;  4I5L C;  4H2B A;  3H62 B;  4ZVZ A;  2NPP C;  5EQV A;  2WDF A;  2Q8U A;  4J6O A;  2YVT A;  2BDX A;  2DFJ A;  4V0W A;  1S8E A;  2O8A A;  4O4K A;  1G5B A;  4MOV A;  2CV9 A;  4O5G A;  2R17 A;  4H2I A;  5INB A;  3QFK A;  4FCX A;  4LTY A;  3H69 A;  4OR9 A;  4O43 A;  1XZW A;  2WDD A;  4V0X A;  1SU1 A;  4DSY A;  1S70 A;  1OIE A;  2QFR A;  3H60 A;  3JYF A;  4JA9 A;  2ZBM A;  4ORC A;  4MP0 A;  3K7V C;  4O24 A;  2DXL A;  4H2F A;  4XPN A;  1W24 A;  1IT6 A;  1HO5 A;  4H1Y P;  1AUI A;  4IL1 A;  3RL4 A;  1OID A;  4M0V A;  3GVE A;  3TGH A;  2IE3 C;  2NYM C;  3ZU0 A;  2IAE C;  4ORB A;  3ZTV A;  3PSO A;  2WDC A;  3QFN A;  4FBQ A;  3CK2 A;  1QHW A;  4ORA A;  4KKZ A;  3H66 A;  4H2G A;  4TUI A;  4YKE A;  2Z06 A;  2GJU A;  5IOH A;  2O8G A;  4F0Z A;  3FGA C;  5JPE A;  2HYP A;  4MOY A;  3RL5 A;  3RQZ A;  1T71 A;  3AUZ A;  2AHD A;  3IVE A;  2YEQ A;  3AV0 A;  2KKN A;  2USH A;  3H68 A;  3T1I A;  3D03 A;  3ICF A;  2ZO9 B;  1USH A;  1FJM A;  1S3M A;  1U32 A;  2WDE A;  3HVQ A;  5B8I A;  4JA7 A;  2BQ8 X;  5JPF A;  3FLO A;  4WWL A;  1HP1 A;  3H63 A;  5DNY A;  3H67 A;  2IE4 C;  4V0V A;  4LAC C;  2JOG A;  1QFC A;  3K7W C;  5J28 A;  4NZV A;  2NXF A;  2HY1 A;  2HYO A;  2Z1A A;  3E0J A;  4I5N C;  5F3W A; 
#chains in the Genus database with same CATH homology
 4LU9 A;  4FBK A;  2QFP A;  3PSN A;  3EGG A;  1WAR A;  3KBP A;  3THO B;  4UT3 B;  3DSD A;  2Z72 A;  1NNW A;  2ZOA A;  4UT3 A;  4B2O A;  2P6B A;  1KBP A;  4IYP C;  4UWQ A;  3RL3 A;  4H1S A;  4KBP A;  1UF3 A;  5JJT A;  2QJC A;  4ZX2 A;  1TCO A;  1S3L A;  4TUG A;  2DXN A;  1II7 A;  4UT2 A;  2BCD A;  3C9F A;  3E7B A;  3DW8 C;  5GTU A;  2NYL C;  3QFO A;  4G9J A;  5HPE A;  1T70 A;  2A22 A;  4FBW A;  1OI8 A;  1JK7 A;  3H61 A;  4Q7F A;  3DSC A;  1UTE A;  3QG5 C;  3IVD A;  1Z2W A;  1S3N A;  3EGH A;  1Z2X A;  3IB7 A;  3P71 C;  1HPU A;  2XMO A;  3C5W C;  3E7A A;  1M63 A;  1XM7 A;  3IB8 A;  1V73 A;  3THN A;  3V4Y A;  3N5U A;  4DHL A;  4DT2 A;  5C1V A;  3QFM A;  4HD0 A;  3LL8 A;  1S95 A;  1WAO 1;  1MF8 A;  3H64 A;  4I5L C;  4H2B A;  3H62 B;  4ZVZ A;  2NPP C;  5EQV A;  2WDF A;  2Q8U A;  4J6O A;  2YVT A;  2BDX A;  2DFJ A;  4V0W A;  1S8E A;  2O8A A;  4O4K A;  1G5B A;  4MOV A;  2CV9 A;  4O5G A;  2R17 A;  4H2I A;  5INB A;  3QFK A;  4FCX A;  4LTY A;  3H69 A;  4OR9 A;  4O43 A;  1XZW A;  2WDD A;  4V0X A;  1SU1 A;  4DSY A;  1S70 A;  1OIE A;  2QFR A;  3H60 A;  3JYF A;  4JA9 A;  2ZBM A;  4ORC A;  4MP0 A;  3K7V C;  4O24 A;  2DXL A;  4H2F A;  4XPN A;  1W24 A;  1IT6 A;  1HO5 A;  4H1Y P;  1AUI A;  4IL1 A;  3RL4 A;  1OID A;  4M0V A;  3GVE A;  3TGH A;  2IE3 C;  2NYM C;  3ZU0 A;  2IAE C;  4ORB A;  3ZTV A;  3PSO A;  2WDC A;  3QFN A;  4FBQ A;  3CK2 A;  1QHW A;  4ORA A;  4KKZ A;  3H66 A;  4H2G A;  4TUI A;  4YKE A;  2Z06 A;  2GJU A;  5IOH A;  2O8G A;  4F0Z A;  3FGA C;  5JPE A;  2HYP A;  4MOY A;  3RL5 A;  3RQZ A;  1T71 A;  3AUZ A;  2AHD A;  3IVE A;  2YEQ A;  3AV0 A;  2KKN A;  2USH A;  3H68 A;  3T1I A;  3D03 A;  3ICF A;  2ZO9 B;  1USH A;  1FJM A;  1S3M A;  1U32 A;  2WDE A;  3HVQ A;  5B8I A;  4JA7 A;  2BQ8 X;  5JPF A;  3FLO A;  4WWL A;  1HP1 A;  3H63 A;  5DNY A;  3H67 A;  2IE4 C;  4V0V A;  4LAC C;  2JOG A;  1QFC A;  3K7W C;  5J28 A;  4NZV A;  2NXF A;  2HY1 A;  2HYO A;  2Z1A A;  3E0J A;  4I5N C;  5F3W A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...