3FLOA

Crystal structure of the carboxyl-terminal domain of yeast dna polymerase alpha in complex with its b subunit
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
458
structure length
433
Chain Sequence
RTMRQNLQEASDVLDDQIESFTKIIQNHYKLSPNDFADPTIQSQSEIYAVGRIVPDSPTYDKFLNPESLSLETSRMGGVGRRVRLDLSQVNELSFFLGQIVAFKGKNANGDYFTVNSILPLPYPNSPVSTSQELQEFQANLEGSSLKVIVTCGPYFANDNFSLELLQEFIDSINNEVKPHVLIMFGPFIDITHPLIASGKLPNFPQFKTQPKTLDELFLKLFTPILKTISPHIQTVLIPSTKDAISNHAAYPQASLIRKALQLPKRNFKCMANPSSFQINEIYFGCSNVDTFKDLKEVIKGGTTSSRYRLDRVSEHILQQRRYYPIFPGSIRTHISGADLDVSYLGLTEFVGGFSPDIMIIPSELQHFARVVQNVVVINPGRFIRATGNRGSYAQITVQCPDLEDGKLTLVEGEEPVYLHNVWKRARVDLIAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title 3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
pubmed doi rcsb
molecule tags Transferase
source organism Saccharomyces cerevisiae
molecule keywords DNA polymerase alpha subunit B
total genus 123
structure length 433
sequence length 458
chains with identical sequence C, E, G
ec nomenclature
pdb deposition date 2008-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04042 DNA_pol_E_B DNA polymerase alpha/epsilon subunit B
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.60 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3floA02
3FLOA
chains in the Genus database with same CATH superfamily
1S3MA 3C9FA 3TGHA 2GJUA 3FLOA 2IE4C 3D03A 3DW8C 4H2IA 2YVTA 4JA9A 1XM7A 4LTYA 1S3NA 1HO5A 3QFMA 3RL4A 2O8AA 2YEQA 1WARA 3IB8A 3LL8A 4TUGA 4H1SA 4B2OA 1XZWA 3RL5A 4TUIA 2O8GA 1S3LA 3EGGA 4LACC 4O43A 4UT3A 3H61A 4O4KA 4V0XA 3DSCA 3QG5C 2XMOA 4FBKA 2R17A 2HY1A 3H63A 4UT3B 2NYLC 3THNA 2ZBMA 3H69A 2JOGA 1QHWA 3ZTVA 3EGHA 2DXLA 3QFOA 3DSDA 5HPEA 3E7BA 2Z72A 4FBQA 2WDFA 3H62B 3JYFA 4ZX2A 5JPEA 2WDCA 3V4YA 1U32A 3PSNA 3AV0A 4UT2A 4V0WA 1IT6A 1FJMA 5JJTA 2BDXA 2NYMC 2P6BA 4V0VA 4HD0A 2KKNA 5INBA 4J6OA 1W24A 2WDEA 4YKEA 5DNYA 3CK2A 5C1VA 1HP1A 1M63A 3T1IA 4LU9A 3H66A 4ORBA 1Z2WA 3H68A 5EQVA 4H1YP 2DFJA 2QFPA 1TCOA 5IOHA 5F3WA 1WAO1 2A22A 5J28A 4F0ZA 1USHA 1II7A 3H64A 1OIEA 2Q8UA 3IVDA 1T71A 3QFKA 3PSOA 4UWQA 1NNWA 4O5GA 4H2GA 4DT2A 4IL1A 4Q7FA 4NZVA 2QJCA 3H67A 2HYOA 1MF8A 2IAEC 4XPNA 3THOB 1QFCA 4MOVA 1HPUA 5B8IA 1S95A 2BCDA 3GVEA 4O24A 3ICFA 4JA7A 4ZVZA 4DHLA 1T70A 2AHDA 2HYPA 3IB7A 1OI8A 4FCXA 1G5BA 1S8EA 2ZOAA 4IYPC 4KBPA 1JK7A 2QFRA 2IE3C 3H60A 2DXNA 1AUIA 1UF3A 2Z06A 2NXFA 3K7WC 1OIDA 3FGAC 1UTEA 4MOYA 2NPPC 4ORAA 5GTUA 2USHA 2WDDA 4ORCA 4KKZA 2BQ8X 3IVEA 1V73A 4I5LC 3ZU0A 3HVQA 5JPFA 4OR9A 1SU1A 3AUZA 3KBPA 3QFNA 2Z1AA 4MP0A 1Z2XA 1KBPA 3P71C 3K7VC 3RQZA 4FBWA 4M0VA 3E0JA 4G9JA 4WWLA 3N5UA 3RL3A 1S70A 4H2FA 2CV9A 4I5NC 2ZO9B 4H2BA 3E7AA 4DSYA 3C5WC
chains in the Genus database with same CATH topology
1S3MA 3C9FA 3TGHA 2GJUA 3FLOA 2IE4C 3D03A 3DW8C 4H2IA 2YVTA 4JA9A 1XM7A 4LTYA 1S3NA 1HO5A 3QFMA 3RL4A 2O8AA 2YEQA 1WARA 3IB8A 3LL8A 4TUGA 4H1SA 4B2OA 1XZWA 3RL5A 4TUIA 2O8GA 1S3LA 3EGGA 4LACC 4O43A 4UT3A 3H61A 4O4KA 4V0XA 3DSCA 3QG5C 2XMOA 4FBKA 2R17A 2HY1A 3H63A 4UT3B 2NYLC 3THNA 2ZBMA 3H69A 2JOGA 1QHWA 3ZTVA 3EGHA 2DXLA 3QFOA 3DSDA 5HPEA 3E7BA 2Z72A 4FBQA 2WDFA 3H62B 3JYFA 4ZX2A 5JPEA 2WDCA 3V4YA 1U32A 3PSNA 3AV0A 4UT2A 4V0WA 1IT6A 1FJMA 5JJTA 2BDXA 2NYMC 2P6BA 4V0VA 4HD0A 2KKNA 5INBA 4J6OA 1W24A 2WDEA 4YKEA 5DNYA 3CK2A 5C1VA 1HP1A 1M63A 3T1IA 4LU9A 3H66A 4ORBA 1Z2WA 3H68A 5EQVA 4H1YP 2DFJA 2QFPA 1TCOA 5IOHA 5F3WA 1WAO1 2A22A 5J28A 4F0ZA 1USHA 1II7A 3H64A 1OIEA 2Q8UA 3IVDA 1T71A 3QFKA 3PSOA 4UWQA 1NNWA 4O5GA 4H2GA 4DT2A 4IL1A 4Q7FA 4NZVA 2QJCA 3H67A 2HYOA 1MF8A 2IAEC 4XPNA 3THOB 1QFCA 4MOVA 1HPUA 5B8IA 1S95A 2BCDA 3GVEA 4O24A 3ICFA 4JA7A 4ZVZA 4DHLA 1T70A 2AHDA 2HYPA 3IB7A 1OI8A 4FCXA 1G5BA 1S8EA 2ZOAA 4IYPC 4KBPA 1JK7A 2QFRA 2IE3C 3H60A 2DXNA 1AUIA 1UF3A 2Z06A 2NXFA 3K7WC 1OIDA 3FGAC 1UTEA 4MOYA 2NPPC 4ORAA 5GTUA 2USHA 2WDDA 4ORCA 4KKZA 2BQ8X 3IVEA 1V73A 4I5LC 3ZU0A 3HVQA 5JPFA 4OR9A 1SU1A 3AUZA 3KBPA 3QFNA 2Z1AA 4MP0A 1Z2XA 1KBPA 3P71C 3K7VC 3RQZA 4FBWA 4M0VA 3E0JA 4G9JA 4WWLA 3N5UA 3RL3A 1S70A 4H2FA 2CV9A 4I5NC 2ZO9B 4H2BA 3E7AA 4DSYA 3C5WC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FLO A; 
#chains in the Genus database with same CATH topology
 1S3M A;  3C9F A;  3TGH A;  2GJU A;  3FLO A;  2IE4 C;  3D03 A;  3DW8 C;  4H2I A;  2YVT A;  4JA9 A;  1XM7 A;  4LTY A;  1S3N A;  1HO5 A;  3QFM A;  3RL4 A;  2O8A A;  2YEQ A;  1WAR A;  3IB8 A;  3LL8 A;  4TUG A;  4H1S A;  4B2O A;  1XZW A;  3RL5 A;  4TUI A;  2O8G A;  1S3L A;  3EGG A;  4LAC C;  4O43 A;  4UT3 A;  3H61 A;  4O4K A;  4V0X A;  3DSC A;  3QG5 C;  2XMO A;  4FBK A;  2R17 A;  2HY1 A;  3H63 A;  4UT3 B;  2NYL C;  3THN A;  2ZBM A;  3H69 A;  2JOG A;  1QHW A;  3ZTV A;  3EGH A;  2DXL A;  3QFO A;  3DSD A;  5HPE A;  3E7B A;  2Z72 A;  4FBQ A;  2WDF A;  3H62 B;  3JYF A;  4ZX2 A;  5JPE A;  2WDC A;  3V4Y A;  1U32 A;  3PSN A;  3AV0 A;  4UT2 A;  4V0W A;  1IT6 A;  1FJM A;  5JJT A;  2BDX A;  2NYM C;  2P6B A;  4V0V A;  4HD0 A;  2KKN A;  5INB A;  4J6O A;  1W24 A;  2WDE A;  4YKE A;  5DNY A;  3CK2 A;  5C1V A;  1HP1 A;  1M63 A;  3T1I A;  4LU9 A;  3H66 A;  4ORB A;  1Z2W A;  3H68 A;  5EQV A;  4H1Y P;  2DFJ A;  2QFP A;  1TCO A;  5IOH A;  5F3W A;  1WAO 1;  2A22 A;  5J28 A;  4F0Z A;  1USH A;  1II7 A;  3H64 A;  1OIE A;  2Q8U A;  3IVD A;  1T71 A;  3QFK A;  3PSO A;  4UWQ A;  1NNW A;  4O5G A;  4H2G A;  4DT2 A;  4IL1 A;  4Q7F A;  4NZV A;  2QJC A;  3H67 A;  2HYO A;  1MF8 A;  2IAE C;  4XPN A;  3THO B;  1QFC A;  4MOV A;  1HPU A;  5B8I A;  1S95 A;  2BCD A;  3GVE A;  4O24 A;  3ICF A;  4JA7 A;  4ZVZ A;  4DHL A;  1T70 A;  2AHD A;  2HYP A;  3IB7 A;  1OI8 A;  4FCX A;  1G5B A;  1S8E A;  2ZOA A;  4IYP C;  4KBP A;  1JK7 A;  2QFR A;  2IE3 C;  3H60 A;  2DXN A;  1AUI A;  1UF3 A;  2Z06 A;  2NXF A;  3K7W C;  1OID A;  3FGA C;  1UTE A;  4MOY A;  2NPP C;  4ORA A;  5GTU A;  2USH A;  2WDD A;  4ORC A;  4KKZ A;  2BQ8 X;  3IVE A;  1V73 A;  4I5L C;  3ZU0 A;  3HVQ A;  5JPF A;  4OR9 A;  1SU1 A;  3AUZ A;  3KBP A;  3QFN A;  2Z1A A;  4MP0 A;  1Z2X A;  1KBP A;  3P71 C;  3K7V C;  3RQZ A;  4FBW A;  4M0V A;  3E0J A;  4G9J A;  4WWL A;  3N5U A;  3RL3 A;  1S70 A;  4H2F A;  2CV9 A;  4I5N C;  2ZO9 B;  4H2B A;  3E7A A;  4DSY A;  3C5W C; 
#chains in the Genus database with same CATH homology
 1S3M A;  3C9F A;  3TGH A;  2GJU A;  3FLO A;  2IE4 C;  3D03 A;  3DW8 C;  4H2I A;  2YVT A;  4JA9 A;  1XM7 A;  4LTY A;  1S3N A;  1HO5 A;  3QFM A;  3RL4 A;  2O8A A;  2YEQ A;  1WAR A;  3IB8 A;  3LL8 A;  4TUG A;  4H1S A;  4B2O A;  1XZW A;  3RL5 A;  4TUI A;  2O8G A;  1S3L A;  3EGG A;  4LAC C;  4O43 A;  4UT3 A;  3H61 A;  4O4K A;  4V0X A;  3DSC A;  3QG5 C;  2XMO A;  4FBK A;  2R17 A;  2HY1 A;  3H63 A;  4UT3 B;  2NYL C;  3THN A;  2ZBM A;  3H69 A;  2JOG A;  1QHW A;  3ZTV A;  3EGH A;  2DXL A;  3QFO A;  3DSD A;  5HPE A;  3E7B A;  2Z72 A;  4FBQ A;  2WDF A;  3H62 B;  3JYF A;  4ZX2 A;  5JPE A;  2WDC A;  3V4Y A;  1U32 A;  3PSN A;  3AV0 A;  4UT2 A;  4V0W A;  1IT6 A;  1FJM A;  5JJT A;  2BDX A;  2NYM C;  2P6B A;  4V0V A;  4HD0 A;  2KKN A;  5INB A;  4J6O A;  1W24 A;  2WDE A;  4YKE A;  5DNY A;  3CK2 A;  5C1V A;  1HP1 A;  1M63 A;  3T1I A;  4LU9 A;  3H66 A;  4ORB A;  1Z2W A;  3H68 A;  5EQV A;  4H1Y P;  2DFJ A;  2QFP A;  1TCO A;  5IOH A;  5F3W A;  1WAO 1;  2A22 A;  5J28 A;  4F0Z A;  1USH A;  1II7 A;  3H64 A;  1OIE A;  2Q8U A;  3IVD A;  1T71 A;  3QFK A;  3PSO A;  4UWQ A;  1NNW A;  4O5G A;  4H2G A;  4DT2 A;  4IL1 A;  4Q7F A;  4NZV A;  2QJC A;  3H67 A;  2HYO A;  1MF8 A;  2IAE C;  4XPN A;  3THO B;  1QFC A;  4MOV A;  1HPU A;  5B8I A;  1S95 A;  2BCD A;  3GVE A;  4O24 A;  3ICF A;  4JA7 A;  4ZVZ A;  4DHL A;  1T70 A;  2AHD A;  2HYP A;  3IB7 A;  1OI8 A;  4FCX A;  1G5B A;  1S8E A;  2ZOA A;  4IYP C;  4KBP A;  1JK7 A;  2QFR A;  2IE3 C;  3H60 A;  2DXN A;  1AUI A;  1UF3 A;  2Z06 A;  2NXF A;  3K7W C;  1OID A;  3FGA C;  1UTE A;  4MOY A;  2NPP C;  4ORA A;  5GTU A;  2USH A;  2WDD A;  4ORC A;  4KKZ A;  2BQ8 X;  3IVE A;  1V73 A;  4I5L C;  3ZU0 A;  3HVQ A;  5JPF A;  4OR9 A;  1SU1 A;  3AUZ A;  3KBP A;  3QFN A;  2Z1A A;  4MP0 A;  1Z2X A;  1KBP A;  3P71 C;  3K7V C;  3RQZ A;  4FBW A;  4M0V A;  3E0J A;  4G9J A;  4WWL A;  3N5U A;  3RL3 A;  1S70 A;  4H2F A;  2CV9 A;  4I5N C;  2ZO9 B;  4H2B A;  3E7A A;  4DSY A;  3C5W C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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