3H68A

Catalytic domain of human serine/threonine phosphatase 5 (pp5c)with two zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
315
structure length
315
Chain Sequence
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 5
total genus 109
structure length 315
sequence length 315
chains with identical sequence D
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3h68A00
3AUZA 3H61A 3AV0A 2GJUA 4H2GA 4LACC 1WAO1 4O4KA 2XMOA 1XZWA 4ZVZA 1T70A 4G9JA 3H64A 2NYMC 1OIEA 3H68A 5IOHA 3RQZA 4ORCA 3DW8C 3LL8A 4FBKA 4ORAA 4LTYA 5EQVA 1IT6A 4H2IA 2AHDA 1QHWA 4H1YP 1Z2WA 2USHA 3ICFA 2Q8UA 4IYPC 2A22A 1FJMA 3V4YA 2Z06A 3H66A 2IAEC 2QFPA 2HYPA 3IB7A 3IVDA 4V0WA 1S3MA 3H63A 1S3LA 5JPFA 4TUIA 3RL4A 4V0XA 4I5NC 4O24A 2WDFA 4FBWA 2QFRA 4DHLA 1U32A 3TGHA 1G5BA 4IL1A 2NXFA 3DSCA 2NPPC 2WDCA 3QFMA 4ORBA 1S3NA 3K7WC 3P71C 2BQ8X 1S8EA 4F0ZA 4JA9A 4OR9A 5INBA 4TUGA 1MF8A 3T1IA 2YVTA 1UTEA 4FBQA 1TCOA 2BDXA 2HY1A 1HO5A 3C5WC 4O5GA 4Q7FA 3RL5A 3PSOA 4YKEA 3JYFA 5HPEA 2BCDA 1M63A 3QG5C 4KKZA 3C9FA 1AUIA 3E7BA 1S95A 4LU9A 4UT2A 5J28A 3EGHA 2Z72A 3CK2A 1V73A 4FCXA 4DSYA 3THOB 2HYOA 1NNWA 1Z2XA 5C1VA 2DFJA 3ZTVA 1KBPA 2IE3C 2JOGA 4UT3B 1JK7A 4KBPA 3QFKA 5DNYA 4NZVA 1II7A 3PSNA 1HPUA 1T71A 2R17A 4M0VA 5F3WA 4B2OA 2KKNA 3DSDA 3H62B 2P6BA 5JJTA 2QJCA 4MP0A 3E7AA 1QFCA 3GVEA 1W24A 3H69A 2O8GA 3K7VC 3QFNA 2ZBMA 1SU1A 5JPEA 3IVEA 3QFOA 4UWQA 1WARA 2CV9A 2O8AA 4V0VA 3EGGA 3H67A 5GTUA 3H60A 4JA7A 4J6OA 1OI8A 3FGAC 1HP1A 2WDDA 1USHA 2NYLC 4H2BA 3N5UA 4H1SA 1S70A 3RL3A 4MOVA 3ZU0A 4UT3A 3KBPA 2IE4C 2Z1AA 3THNA 4MOYA 4O43A 4H2FA 4DT2A 4XPNA 4WWLA 4I5LC 1OIDA 5B8IA 4HD0A 1UF3A 3HVQA 4ZX2A 3IB8A 1XM7A 2WDEA
chains in the Genus database with same CATH superfamily
3AUZA 3H61A 3AV0A 2GJUA 4H2GA 4LACC 1WAO1 4O4KA 2XMOA 1XZWA 4ZVZA 1T70A 4G9JA 3H64A 2NYMC 1OIEA 3H68A 5IOHA 3RQZA 4ORCA 3DW8C 3LL8A 4FBKA 4ORAA 2DXNA 4LTYA 5EQVA 1IT6A 4H2IA 2AHDA 1QHWA 4H1YP 1Z2WA 2USHA 2ZOAA 3ICFA 2Q8UA 4IYPC 2A22A 1FJMA 3V4YA 2Z06A 3H66A 2IAEC 2QFPA 2HYPA 3IB7A 3IVDA 4V0WA 1S3MA 3H63A 1S3LA 2YEQA 5JPFA 4TUIA 3RL4A 4V0XA 4I5NC 4O24A 2WDFA 4FBWA 2QFRA 4DHLA 1U32A 3TGHA 1G5BA 4IL1A 2NXFA 3DSCA 2NPPC 2WDCA 3QFMA 4ORBA 1S3NA 3K7WC 3P71C 2BQ8X 1S8EA 4F0ZA 4JA9A 4OR9A 5INBA 4TUGA 1MF8A 3T1IA 2YVTA 1UTEA 4FBQA 1TCOA 2BDXA 2HY1A 1HO5A 3C5WC 4O5GA 4Q7FA 3RL5A 3PSOA 4YKEA 3JYFA 5HPEA 2BCDA 3D03A 1M63A 3QG5C 4KKZA 3C9FA 1AUIA 3E7BA 1S95A 4LU9A 4UT2A 5J28A 3EGHA 2Z72A 3CK2A 1V73A 4FCXA 4DSYA 3THOB 2DXLA 2HYOA 1NNWA 1Z2XA 5C1VA 2DFJA 3ZTVA 1KBPA 2IE3C 2JOGA 4UT3B 1JK7A 4KBPA 3QFKA 5DNYA 4NZVA 1II7A 3PSNA 1HPUA 1T71A 2R17A 4M0VA 5F3WA 4B2OA 2KKNA 3DSDA 3H62B 2P6BA 5JJTA 2QJCA 4MP0A 3E7AA 1QFCA 3GVEA 1W24A 3H69A 2O8GA 3K7VC 3QFNA 2ZBMA 1SU1A 5JPEA 3IVEA 3QFOA 4UWQA 1WARA 3FLOA 2CV9A 2O8AA 4V0VA 3E0JA 3EGGA 3H67A 5GTUA 3H60A 4JA7A 4J6OA 1OI8A 3FGAC 1HP1A 2WDDA 1USHA 2NYLC 4H2BA 3N5UA 4H1SA 1S70A 3RL3A 4MOVA 3ZU0A 4UT3A 3KBPA 2IE4C 2Z1AA 3THNA 4MOYA 4O43A 4H2FA 4DT2A 4XPNA 4WWLA 4I5LC 1OIDA 5B8IA 4HD0A 1UF3A 3HVQA 4ZX2A 3IB8A 1XM7A 2ZO9B 2WDEA
chains in the Genus database with same CATH topology
3AUZA 3H61A 3AV0A 2GJUA 4H2GA 4LACC 1WAO1 4O4KA 2XMOA 1XZWA 4ZVZA 1T70A 4G9JA 3H64A 2NYMC 1OIEA 3H68A 5IOHA 3RQZA 4ORCA 3DW8C 3LL8A 4FBKA 4ORAA 2DXNA 4LTYA 5EQVA 1IT6A 4H2IA 2AHDA 1QHWA 4H1YP 1Z2WA 2USHA 2ZOAA 3ICFA 2Q8UA 4IYPC 2A22A 1FJMA 3V4YA 2Z06A 3H66A 2IAEC 2QFPA 2HYPA 3IB7A 3IVDA 4V0WA 1S3MA 3H63A 1S3LA 2YEQA 5JPFA 4TUIA 3RL4A 4V0XA 4I5NC 4O24A 2WDFA 4FBWA 2QFRA 4DHLA 1U32A 3TGHA 1G5BA 4IL1A 2NXFA 3DSCA 2NPPC 2WDCA 3QFMA 4ORBA 1S3NA 3K7WC 3P71C 2BQ8X 1S8EA 4F0ZA 4JA9A 4OR9A 5INBA 4TUGA 1MF8A 3T1IA 2YVTA 1UTEA 4FBQA 1TCOA 2BDXA 2HY1A 1HO5A 3C5WC 4O5GA 4Q7FA 3RL5A 3PSOA 4YKEA 3JYFA 5HPEA 2BCDA 3D03A 1M63A 3QG5C 4KKZA 3C9FA 1AUIA 3E7BA 1S95A 4LU9A 4UT2A 5J28A 3EGHA 2Z72A 3CK2A 1V73A 4FCXA 4DSYA 3THOB 2DXLA 2HYOA 1NNWA 1Z2XA 5C1VA 2DFJA 3ZTVA 1KBPA 2IE3C 2JOGA 4UT3B 1JK7A 4KBPA 3QFKA 5DNYA 4NZVA 1II7A 3PSNA 1HPUA 1T71A 2R17A 4M0VA 5F3WA 4B2OA 2KKNA 3DSDA 3H62B 2P6BA 5JJTA 2QJCA 4MP0A 3E7AA 1QFCA 3GVEA 1W24A 3H69A 2O8GA 3K7VC 3QFNA 2ZBMA 1SU1A 5JPEA 3IVEA 3QFOA 4UWQA 1WARA 3FLOA 2CV9A 2O8AA 4V0VA 3E0JA 3EGGA 3H67A 5GTUA 3H60A 4JA7A 4J6OA 1OI8A 3FGAC 1HP1A 2WDDA 1USHA 2NYLC 4H2BA 3N5UA 4H1SA 1S70A 3RL3A 4MOVA 3ZU0A 4UT3A 3KBPA 2IE4C 2Z1AA 3THNA 4MOYA 4O43A 4H2FA 4DT2A 4XPNA 4WWLA 4I5LC 1OIDA 5B8IA 4HD0A 1UF3A 3HVQA 4ZX2A 3IB8A 1XM7A 2ZO9B 2WDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AUZ A;  3H61 A;  3AV0 A;  2GJU A;  4H2G A;  4LAC C;  1WAO 1;  4O4K A;  2XMO A;  1XZW A;  4ZVZ A;  1T70 A;  4G9J A;  3H64 A;  2NYM C;  1OIE A;  3H68 A;  5IOH A;  3RQZ A;  4ORC A;  3DW8 C;  3LL8 A;  4FBK A;  4ORA A;  4LTY A;  5EQV A;  1IT6 A;  4H2I A;  2AHD A;  1QHW A;  4H1Y P;  1Z2W A;  2USH A;  3ICF A;  2Q8U A;  4IYP C;  2A22 A;  1FJM A;  3V4Y A;  2Z06 A;  3H66 A;  2IAE C;  2QFP A;  2HYP A;  3IB7 A;  3IVD A;  4V0W A;  1S3M A;  3H63 A;  1S3L A;  5JPF A;  4TUI A;  3RL4 A;  4V0X A;  4I5N C;  4O24 A;  2WDF A;  4FBW A;  2QFR A;  4DHL A;  1U32 A;  3TGH A;  1G5B A;  4IL1 A;  2NXF A;  3DSC A;  2NPP C;  2WDC A;  3QFM A;  4ORB A;  1S3N A;  3K7W C;  3P71 C;  2BQ8 X;  1S8E A;  4F0Z A;  4JA9 A;  4OR9 A;  5INB A;  4TUG A;  1MF8 A;  3T1I A;  2YVT A;  1UTE A;  4FBQ A;  1TCO A;  2BDX A;  2HY1 A;  1HO5 A;  3C5W C;  4O5G A;  4Q7F A;  3RL5 A;  3PSO A;  4YKE A;  3JYF A;  5HPE A;  2BCD A;  1M63 A;  3QG5 C;  4KKZ A;  3C9F A;  1AUI A;  3E7B A;  1S95 A;  4LU9 A;  4UT2 A;  5J28 A;  3EGH A;  2Z72 A;  3CK2 A;  1V73 A;  4FCX A;  4DSY A;  3THO B;  2HYO A;  1NNW A;  1Z2X A;  5C1V A;  2DFJ A;  3ZTV A;  1KBP A;  2IE3 C;  2JOG A;  4UT3 B;  1JK7 A;  4KBP A;  3QFK A;  5DNY A;  4NZV A;  1II7 A;  3PSN A;  1HPU A;  1T71 A;  2R17 A;  4M0V A;  5F3W A;  4B2O A;  2KKN A;  3DSD A;  3H62 B;  2P6B A;  5JJT A;  2QJC A;  4MP0 A;  3E7A A;  1QFC A;  3GVE A;  1W24 A;  3H69 A;  2O8G A;  3K7V C;  3QFN A;  2ZBM A;  1SU1 A;  5JPE A;  3IVE A;  3QFO A;  4UWQ A;  1WAR A;  2CV9 A;  2O8A A;  4V0V A;  3EGG A;  3H67 A;  5GTU A;  3H60 A;  4JA7 A;  4J6O A;  1OI8 A;  3FGA C;  1HP1 A;  2WDD A;  1USH A;  2NYL C;  4H2B A;  3N5U A;  4H1S A;  1S70 A;  3RL3 A;  4MOV A;  3ZU0 A;  4UT3 A;  3KBP A;  2IE4 C;  2Z1A A;  3THN A;  4MOY A;  4O43 A;  4H2F A;  4DT2 A;  4XPN A;  4WWL A;  4I5L C;  1OID A;  5B8I A;  4HD0 A;  1UF3 A;  3HVQ A;  4ZX2 A;  3IB8 A;  1XM7 A;  2WDE A; 
#chains in the Genus database with same CATH topology
 3AUZ A;  3H61 A;  3AV0 A;  2GJU A;  4H2G A;  4LAC C;  1WAO 1;  4O4K A;  2XMO A;  1XZW A;  4ZVZ A;  1T70 A;  4G9J A;  3H64 A;  2NYM C;  1OIE A;  3H68 A;  5IOH A;  3RQZ A;  4ORC A;  3DW8 C;  3LL8 A;  4FBK A;  4ORA A;  2DXN A;  4LTY A;  5EQV A;  1IT6 A;  4H2I A;  2AHD A;  1QHW A;  4H1Y P;  1Z2W A;  2USH A;  2ZOA A;  3ICF A;  2Q8U A;  4IYP C;  2A22 A;  1FJM A;  3V4Y A;  2Z06 A;  3H66 A;  2IAE C;  2QFP A;  2HYP A;  3IB7 A;  3IVD A;  4V0W A;  1S3M A;  3H63 A;  1S3L A;  2YEQ A;  5JPF A;  4TUI A;  3RL4 A;  4V0X A;  4I5N C;  4O24 A;  2WDF A;  4FBW A;  2QFR A;  4DHL A;  1U32 A;  3TGH A;  1G5B A;  4IL1 A;  2NXF A;  3DSC A;  2NPP C;  2WDC A;  3QFM A;  4ORB A;  1S3N A;  3K7W C;  3P71 C;  2BQ8 X;  1S8E A;  4F0Z A;  4JA9 A;  4OR9 A;  5INB A;  4TUG A;  1MF8 A;  3T1I A;  2YVT A;  1UTE A;  4FBQ A;  1TCO A;  2BDX A;  2HY1 A;  1HO5 A;  3C5W C;  4O5G A;  4Q7F A;  3RL5 A;  3PSO A;  4YKE A;  3JYF A;  5HPE A;  2BCD A;  3D03 A;  1M63 A;  3QG5 C;  4KKZ A;  3C9F A;  1AUI A;  3E7B A;  1S95 A;  4LU9 A;  4UT2 A;  5J28 A;  3EGH A;  2Z72 A;  3CK2 A;  1V73 A;  4FCX A;  4DSY A;  3THO B;  2DXL A;  2HYO A;  1NNW A;  1Z2X A;  5C1V A;  2DFJ A;  3ZTV A;  1KBP A;  2IE3 C;  2JOG A;  4UT3 B;  1JK7 A;  4KBP A;  3QFK A;  5DNY A;  4NZV A;  1II7 A;  3PSN A;  1HPU A;  1T71 A;  2R17 A;  4M0V A;  5F3W A;  4B2O A;  2KKN A;  3DSD A;  3H62 B;  2P6B A;  5JJT A;  2QJC A;  4MP0 A;  3E7A A;  1QFC A;  3GVE A;  1W24 A;  3H69 A;  2O8G A;  3K7V C;  3QFN A;  2ZBM A;  1SU1 A;  5JPE A;  3IVE A;  3QFO A;  4UWQ A;  1WAR A;  3FLO A;  2CV9 A;  2O8A A;  4V0V A;  3E0J A;  3EGG A;  3H67 A;  5GTU A;  3H60 A;  4JA7 A;  4J6O A;  1OI8 A;  3FGA C;  1HP1 A;  2WDD A;  1USH A;  2NYL C;  4H2B A;  3N5U A;  4H1S A;  1S70 A;  3RL3 A;  4MOV A;  3ZU0 A;  4UT3 A;  3KBP A;  2IE4 C;  2Z1A A;  3THN A;  4MOY A;  4O43 A;  4H2F A;  4DT2 A;  4XPN A;  4WWL A;  4I5L C;  1OID A;  5B8I A;  4HD0 A;  1UF3 A;  3HVQ A;  4ZX2 A;  3IB8 A;  1XM7 A;  2ZO9 B;  2WDE A; 
#chains in the Genus database with same CATH homology
 3AUZ A;  3H61 A;  3AV0 A;  2GJU A;  4H2G A;  4LAC C;  1WAO 1;  4O4K A;  2XMO A;  1XZW A;  4ZVZ A;  1T70 A;  4G9J A;  3H64 A;  2NYM C;  1OIE A;  3H68 A;  5IOH A;  3RQZ A;  4ORC A;  3DW8 C;  3LL8 A;  4FBK A;  4ORA A;  2DXN A;  4LTY A;  5EQV A;  1IT6 A;  4H2I A;  2AHD A;  1QHW A;  4H1Y P;  1Z2W A;  2USH A;  2ZOA A;  3ICF A;  2Q8U A;  4IYP C;  2A22 A;  1FJM A;  3V4Y A;  2Z06 A;  3H66 A;  2IAE C;  2QFP A;  2HYP A;  3IB7 A;  3IVD A;  4V0W A;  1S3M A;  3H63 A;  1S3L A;  2YEQ A;  5JPF A;  4TUI A;  3RL4 A;  4V0X A;  4I5N C;  4O24 A;  2WDF A;  4FBW A;  2QFR A;  4DHL A;  1U32 A;  3TGH A;  1G5B A;  4IL1 A;  2NXF A;  3DSC A;  2NPP C;  2WDC A;  3QFM A;  4ORB A;  1S3N A;  3K7W C;  3P71 C;  2BQ8 X;  1S8E A;  4F0Z A;  4JA9 A;  4OR9 A;  5INB A;  4TUG A;  1MF8 A;  3T1I A;  2YVT A;  1UTE A;  4FBQ A;  1TCO A;  2BDX A;  2HY1 A;  1HO5 A;  3C5W C;  4O5G A;  4Q7F A;  3RL5 A;  3PSO A;  4YKE A;  3JYF A;  5HPE A;  2BCD A;  3D03 A;  1M63 A;  3QG5 C;  4KKZ A;  3C9F A;  1AUI A;  3E7B A;  1S95 A;  4LU9 A;  4UT2 A;  5J28 A;  3EGH A;  2Z72 A;  3CK2 A;  1V73 A;  4FCX A;  4DSY A;  3THO B;  2DXL A;  2HYO A;  1NNW A;  1Z2X A;  5C1V A;  2DFJ A;  3ZTV A;  1KBP A;  2IE3 C;  2JOG A;  4UT3 B;  1JK7 A;  4KBP A;  3QFK A;  5DNY A;  4NZV A;  1II7 A;  3PSN A;  1HPU A;  1T71 A;  2R17 A;  4M0V A;  5F3W A;  4B2O A;  2KKN A;  3DSD A;  3H62 B;  2P6B A;  5JJT A;  2QJC A;  4MP0 A;  3E7A A;  1QFC A;  3GVE A;  1W24 A;  3H69 A;  2O8G A;  3K7V C;  3QFN A;  2ZBM A;  1SU1 A;  5JPE A;  3IVE A;  3QFO A;  4UWQ A;  1WAR A;  3FLO A;  2CV9 A;  2O8A A;  4V0V A;  3E0J A;  3EGG A;  3H67 A;  5GTU A;  3H60 A;  4JA7 A;  4J6O A;  1OI8 A;  3FGA C;  1HP1 A;  2WDD A;  1USH A;  2NYL C;  4H2B A;  3N5U A;  4H1S A;  1S70 A;  3RL3 A;  4MOV A;  3ZU0 A;  4UT3 A;  3KBP A;  2IE4 C;  2Z1A A;  3THN A;  4MOY A;  4O43 A;  4H2F A;  4DT2 A;  4XPN A;  4WWL A;  4I5L C;  1OID A;  5B8I A;  4HD0 A;  1UF3 A;  3HVQ A;  4ZX2 A;  3IB8 A;  1XM7 A;  2ZO9 B;  2WDE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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