3K7WC

Protein phosphatase 2a core complex bound to dinophysistoxin-2
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural basis for the reduced toxicity of dinophysistoxin-2.
pubmed doi rcsb
molecule tags Signaling protein/hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 108
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3k7wC00
3E7AA 4KKZA 4YKEA 2QFPA 3JYFA 3H61A 4H2IA 1S3NA 3LL8A 5HPEA 5JJTA 4O43A 3QFOA 2WDEA 1Z2WA 4FCXA 2QJCA 4TUGA 2KKNA 4WWLA 1T71A 4H2GA 3PSOA 5IOHA 1HPUA 4DHLA 1AUIA 2A22A 3CK2A 2CV9A 4LU9A 1OIDA 1SU1A 4ZVZA 3IB8A 1W24A 3P71C 4ORBA 3TGHA 2NYLC 4ORCA 3KBPA 3FGAC 4UWQA 3RQZA 5DNYA 3T1IA 1OI8A 3QFNA 2Z06A 4F0ZA 2IE4C 4G9JA 3AUZA 4OR9A 5B8IA 1XM7A 3PSNA 4IL1A 3QG5C 4UT3B 4JA7A 2WDCA 1S3LA 1S70A 4HD0A 3AV0A 3DSCA 3DW8C 1HP1A 2GJUA 2ZBMA 2JOGA 3H68A 2BDXA 2NPPC 3E7BA 2O8AA 3RL4A 4DT2A 1S3MA 2BCDA 4V0VA 5J28A 4DSYA 2NXFA 2Z72A 2HYOA 2O8GA 3GVEA 4IYPC 4LACC 5EQVA 3V4YA 2USHA 4H1SA 4TUIA 5F3WA 2IAEC 3IVEA 1QFCA 4FBWA 4ORAA 2NYMC 4V0WA 4H2FA 4ZX2A 3DSDA 1QHWA 5INBA 1II7A 2DFJA 2HYPA 3H60A 3RL3A 4LTYA 4UT3A 2XMOA 3H66A 1V73A 2YVTA 3C9FA 3QFKA 1UTEA 4O24A 1UF3A 3ZTVA 4FBQA 4B2OA 4NZVA 1NNWA 1S95A 3C5WC 3THNA 1JK7A 3H67A 4Q7FA 2AHDA 3QFMA 4JA9A 2Z1AA 4KBPA 4UT2A 1TCOA 3K7WC 3IVDA 2HY1A 4V0XA 1FJMA 4MP0A 5C1VA 3H64A 3HVQA 4O4KA 5JPFA 3EGGA 4FBKA 1HO5A 1WARA 1MF8A 1OIEA 1G5BA 2BQ8X 3EGHA 4O5GA 4MOVA 4H1YP 3N5UA 1M63A 1KBPA 4J6OA 4MOYA 5JPEA 3IB7A 1XZWA 2Q8UA 4XPNA 1WAO1 4I5NC 3H63A 2QFRA 3ICFA 3ZU0A 2IE3C 1Z2XA 1USHA 3RL5A 1IT6A 3THOB 2WDDA 4H2BA 2WDFA 1T70A 3H69A 4I5LC 5GTUA 1U32A 2P6BA 2R17A 4M0VA 1S8EA 3K7VC 3H62B
chains in the Genus database with same CATH superfamily
3E7AA 4KKZA 4YKEA 2QFPA 3JYFA 3H61A 4H2IA 1S3NA 3LL8A 5HPEA 5JJTA 4O43A 3QFOA 2WDEA 1Z2WA 4FCXA 2QJCA 4TUGA 2KKNA 4WWLA 1T71A 4H2GA 3PSOA 5IOHA 1HPUA 4DHLA 1AUIA 2A22A 3CK2A 2CV9A 4LU9A 1OIDA 1SU1A 4ZVZA 3IB8A 1W24A 3P71C 4ORBA 3TGHA 2NYLC 4ORCA 3KBPA 3FGAC 4UWQA 3RQZA 5DNYA 3H62B 3T1IA 1OI8A 3QFNA 2Z06A 4F0ZA 2IE4C 4G9JA 3AUZA 4OR9A 5B8IA 1XM7A 3PSNA 4IL1A 3QG5C 4UT3B 2ZOAA 4JA7A 2WDCA 1S3LA 1S70A 4HD0A 3AV0A 3DSCA 3DW8C 1HP1A 2GJUA 2ZBMA 2JOGA 3H68A 2BDXA 2NPPC 3E7BA 2O8AA 3E0JA 3RL4A 4DT2A 1S3MA 2BCDA 4V0VA 5J28A 4DSYA 2NXFA 2Z72A 2HYOA 2O8GA 3GVEA 4IYPC 4LACC 5EQVA 3V4YA 2USHA 4H1SA 4TUIA 5F3WA 2IAEC 3IVEA 1QFCA 4FBWA 4ORAA 2NYMC 4V0WA 4H2FA 4ZX2A 3DSDA 1QHWA 5INBA 1II7A 2DFJA 2HYPA 3H60A 3RL3A 4LTYA 4UT3A 2XMOA 3H66A 1V73A 2YVTA 3C9FA 3QFKA 1UTEA 4O24A 1UF3A 3ZTVA 4FBQA 4B2OA 4NZVA 1NNWA 1S95A 3C5WC 3THNA 1JK7A 3H67A 4Q7FA 2AHDA 3QFMA 2ZO9B 4JA9A 2Z1AA 4KBPA 4UT2A 1TCOA 3K7WC 3IVDA 2HY1A 4V0XA 1FJMA 4MP0A 5C1VA 3H64A 3HVQA 4O4KA 5JPFA 3EGGA 4FBKA 1HO5A 1WARA 3FLOA 1MF8A 1OIEA 1G5BA 2BQ8X 3EGHA 4O5GA 4MOVA 2DXLA 4H1YP 3N5UA 1M63A 1KBPA 4J6OA 4MOYA 5JPEA 3IB7A 1XZWA 2Q8UA 4XPNA 1WAO1 4I5NC 3H63A 2QFRA 3ICFA 3D03A 3ZU0A 2IE3C 1Z2XA 1USHA 3RL5A 1IT6A 3THOB 2WDDA 4H2BA 2WDFA 2YEQA 1T70A 3H69A 4I5LC 5GTUA 1U32A 2P6BA 2R17A 4M0VA 1S8EA 3K7VC 2DXNA
chains in the Genus database with same CATH topology
3E7AA 4KKZA 4YKEA 2QFPA 3JYFA 3H61A 4H2IA 1S3NA 3LL8A 5HPEA 5JJTA 4O43A 3QFOA 2WDEA 1Z2WA 4FCXA 2QJCA 4TUGA 2KKNA 4WWLA 1T71A 4H2GA 3PSOA 5IOHA 1HPUA 4DHLA 1AUIA 2A22A 3CK2A 2CV9A 4LU9A 1OIDA 1SU1A 4ZVZA 3IB8A 1W24A 3P71C 4ORBA 3TGHA 2NYLC 4ORCA 3KBPA 3FGAC 4UWQA 3RQZA 5DNYA 3H62B 3T1IA 1OI8A 3QFNA 2Z06A 4F0ZA 2IE4C 4G9JA 3AUZA 4OR9A 5B8IA 1XM7A 3PSNA 4IL1A 3QG5C 4UT3B 2ZOAA 4JA7A 2WDCA 1S3LA 1S70A 4HD0A 3AV0A 3DSCA 3DW8C 1HP1A 2GJUA 2ZBMA 2JOGA 3H68A 2BDXA 2NPPC 3E7BA 2O8AA 3E0JA 3RL4A 4DT2A 1S3MA 2BCDA 4V0VA 5J28A 4DSYA 2NXFA 2Z72A 2HYOA 2O8GA 3GVEA 4IYPC 4LACC 5EQVA 3V4YA 2USHA 4H1SA 4TUIA 5F3WA 2IAEC 3IVEA 1QFCA 4FBWA 4ORAA 2NYMC 4V0WA 4H2FA 4ZX2A 3DSDA 1QHWA 5INBA 1II7A 2DFJA 2HYPA 3H60A 3RL3A 4LTYA 4UT3A 2XMOA 3H66A 1V73A 2YVTA 3C9FA 3QFKA 1UTEA 4O24A 1UF3A 3ZTVA 4FBQA 4B2OA 4NZVA 1NNWA 1S95A 3C5WC 3THNA 1JK7A 3H67A 4Q7FA 2AHDA 3QFMA 2ZO9B 4JA9A 2Z1AA 4KBPA 4UT2A 1TCOA 3K7WC 3IVDA 2HY1A 4V0XA 1FJMA 4MP0A 5C1VA 3H64A 3HVQA 4O4KA 5JPFA 3EGGA 4FBKA 1HO5A 1WARA 3FLOA 1MF8A 1OIEA 1G5BA 2BQ8X 3EGHA 4O5GA 4MOVA 2DXLA 4H1YP 3N5UA 1M63A 1KBPA 4J6OA 4MOYA 5JPEA 3IB7A 1XZWA 2Q8UA 4XPNA 1WAO1 4I5NC 3H63A 2QFRA 3ICFA 3D03A 3ZU0A 2IE3C 1Z2XA 1USHA 3RL5A 1IT6A 3THOB 2WDDA 4H2BA 2WDFA 2YEQA 1T70A 3H69A 4I5LC 5GTUA 1U32A 2P6BA 2R17A 4M0VA 1S8EA 3K7VC 2DXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E7A A;  4KKZ A;  4YKE A;  2QFP A;  3JYF A;  3H61 A;  4H2I A;  1S3N A;  3LL8 A;  5HPE A;  5JJT A;  4O43 A;  3QFO A;  2WDE A;  1Z2W A;  4FCX A;  2QJC A;  4TUG A;  2KKN A;  4WWL A;  1T71 A;  4H2G A;  3PSO A;  5IOH A;  1HPU A;  4DHL A;  1AUI A;  2A22 A;  3CK2 A;  2CV9 A;  4LU9 A;  1OID A;  1SU1 A;  4ZVZ A;  3IB8 A;  1W24 A;  3P71 C;  4ORB A;  3TGH A;  2NYL C;  4ORC A;  3KBP A;  3FGA C;  4UWQ A;  3RQZ A;  5DNY A;  3T1I A;  1OI8 A;  3QFN A;  2Z06 A;  4F0Z A;  2IE4 C;  4G9J A;  3AUZ A;  4OR9 A;  5B8I A;  1XM7 A;  3PSN A;  4IL1 A;  3QG5 C;  4UT3 B;  4JA7 A;  2WDC A;  1S3L A;  1S70 A;  4HD0 A;  3AV0 A;  3DSC A;  3DW8 C;  1HP1 A;  2GJU A;  2ZBM A;  2JOG A;  3H68 A;  2BDX A;  2NPP C;  3E7B A;  2O8A A;  3RL4 A;  4DT2 A;  1S3M A;  2BCD A;  4V0V A;  5J28 A;  4DSY A;  2NXF A;  2Z72 A;  2HYO A;  2O8G A;  3GVE A;  4IYP C;  4LAC C;  5EQV A;  3V4Y A;  2USH A;  4H1S A;  4TUI A;  5F3W A;  2IAE C;  3IVE A;  1QFC A;  4FBW A;  4ORA A;  2NYM C;  4V0W A;  4H2F A;  4ZX2 A;  3DSD A;  1QHW A;  5INB A;  1II7 A;  2DFJ A;  2HYP A;  3H60 A;  3RL3 A;  4LTY A;  4UT3 A;  2XMO A;  3H66 A;  1V73 A;  2YVT A;  3C9F A;  3QFK A;  1UTE A;  4O24 A;  1UF3 A;  3ZTV A;  4FBQ A;  4B2O A;  4NZV A;  1NNW A;  1S95 A;  3C5W C;  3THN A;  1JK7 A;  3H67 A;  4Q7F A;  2AHD A;  3QFM A;  4JA9 A;  2Z1A A;  4KBP A;  4UT2 A;  1TCO A;  3K7W C;  3IVD A;  2HY1 A;  4V0X A;  1FJM A;  4MP0 A;  5C1V A;  3H64 A;  3HVQ A;  4O4K A;  5JPF A;  3EGG A;  4FBK A;  1HO5 A;  1WAR A;  1MF8 A;  1OIE A;  1G5B A;  2BQ8 X;  3EGH A;  4O5G A;  4MOV A;  4H1Y P;  3N5U A;  1M63 A;  1KBP A;  4J6O A;  4MOY A;  5JPE A;  3IB7 A;  1XZW A;  2Q8U A;  4XPN A;  1WAO 1;  4I5N C;  3H63 A;  2QFR A;  3ICF A;  3ZU0 A;  2IE3 C;  1Z2X A;  1USH A;  3RL5 A;  1IT6 A;  3THO B;  2WDD A;  4H2B A;  2WDF A;  1T70 A;  3H69 A;  4I5L C;  5GTU A;  1U32 A;  2P6B A;  2R17 A;  4M0V A;  1S8E A;  3K7V C;  3H62 B; 
#chains in the Genus database with same CATH topology
 3E7A A;  4KKZ A;  4YKE A;  2QFP A;  3JYF A;  3H61 A;  4H2I A;  1S3N A;  3LL8 A;  5HPE A;  5JJT A;  4O43 A;  3QFO A;  2WDE A;  1Z2W A;  4FCX A;  2QJC A;  4TUG A;  2KKN A;  4WWL A;  1T71 A;  4H2G A;  3PSO A;  5IOH A;  1HPU A;  4DHL A;  1AUI A;  2A22 A;  3CK2 A;  2CV9 A;  4LU9 A;  1OID A;  1SU1 A;  4ZVZ A;  3IB8 A;  1W24 A;  3P71 C;  4ORB A;  3TGH A;  2NYL C;  4ORC A;  3KBP A;  3FGA C;  4UWQ A;  3RQZ A;  5DNY A;  3H62 B;  3T1I A;  1OI8 A;  3QFN A;  2Z06 A;  4F0Z A;  2IE4 C;  4G9J A;  3AUZ A;  4OR9 A;  5B8I A;  1XM7 A;  3PSN A;  4IL1 A;  3QG5 C;  4UT3 B;  2ZOA A;  4JA7 A;  2WDC A;  1S3L A;  1S70 A;  4HD0 A;  3AV0 A;  3DSC A;  3DW8 C;  1HP1 A;  2GJU A;  2ZBM A;  2JOG A;  3H68 A;  2BDX A;  2NPP C;  3E7B A;  2O8A A;  3E0J A;  3RL4 A;  4DT2 A;  1S3M A;  2BCD A;  4V0V A;  5J28 A;  4DSY A;  2NXF A;  2Z72 A;  2HYO A;  2O8G A;  3GVE A;  4IYP C;  4LAC C;  5EQV A;  3V4Y A;  2USH A;  4H1S A;  4TUI A;  5F3W A;  2IAE C;  3IVE A;  1QFC A;  4FBW A;  4ORA A;  2NYM C;  4V0W A;  4H2F A;  4ZX2 A;  3DSD A;  1QHW A;  5INB A;  1II7 A;  2DFJ A;  2HYP A;  3H60 A;  3RL3 A;  4LTY A;  4UT3 A;  2XMO A;  3H66 A;  1V73 A;  2YVT A;  3C9F A;  3QFK A;  1UTE A;  4O24 A;  1UF3 A;  3ZTV A;  4FBQ A;  4B2O A;  4NZV A;  1NNW A;  1S95 A;  3C5W C;  3THN A;  1JK7 A;  3H67 A;  4Q7F A;  2AHD A;  3QFM A;  2ZO9 B;  4JA9 A;  2Z1A A;  4KBP A;  4UT2 A;  1TCO A;  3K7W C;  3IVD A;  2HY1 A;  4V0X A;  1FJM A;  4MP0 A;  5C1V A;  3H64 A;  3HVQ A;  4O4K A;  5JPF A;  3EGG A;  4FBK A;  1HO5 A;  1WAR A;  3FLO A;  1MF8 A;  1OIE A;  1G5B A;  2BQ8 X;  3EGH A;  4O5G A;  4MOV A;  2DXL A;  4H1Y P;  3N5U A;  1M63 A;  1KBP A;  4J6O A;  4MOY A;  5JPE A;  3IB7 A;  1XZW A;  2Q8U A;  4XPN A;  1WAO 1;  4I5N C;  3H63 A;  2QFR A;  3ICF A;  3D03 A;  3ZU0 A;  2IE3 C;  1Z2X A;  1USH A;  3RL5 A;  1IT6 A;  3THO B;  2WDD A;  4H2B A;  2WDF A;  2YEQ A;  1T70 A;  3H69 A;  4I5L C;  5GTU A;  1U32 A;  2P6B A;  2R17 A;  4M0V A;  1S8E A;  3K7V C;  2DXN A; 
#chains in the Genus database with same CATH homology
 3E7A A;  4KKZ A;  4YKE A;  2QFP A;  3JYF A;  3H61 A;  4H2I A;  1S3N A;  3LL8 A;  5HPE A;  5JJT A;  4O43 A;  3QFO A;  2WDE A;  1Z2W A;  4FCX A;  2QJC A;  4TUG A;  2KKN A;  4WWL A;  1T71 A;  4H2G A;  3PSO A;  5IOH A;  1HPU A;  4DHL A;  1AUI A;  2A22 A;  3CK2 A;  2CV9 A;  4LU9 A;  1OID A;  1SU1 A;  4ZVZ A;  3IB8 A;  1W24 A;  3P71 C;  4ORB A;  3TGH A;  2NYL C;  4ORC A;  3KBP A;  3FGA C;  4UWQ A;  3RQZ A;  5DNY A;  3H62 B;  3T1I A;  1OI8 A;  3QFN A;  2Z06 A;  4F0Z A;  2IE4 C;  4G9J A;  3AUZ A;  4OR9 A;  5B8I A;  1XM7 A;  3PSN A;  4IL1 A;  3QG5 C;  4UT3 B;  2ZOA A;  4JA7 A;  2WDC A;  1S3L A;  1S70 A;  4HD0 A;  3AV0 A;  3DSC A;  3DW8 C;  1HP1 A;  2GJU A;  2ZBM A;  2JOG A;  3H68 A;  2BDX A;  2NPP C;  3E7B A;  2O8A A;  3E0J A;  3RL4 A;  4DT2 A;  1S3M A;  2BCD A;  4V0V A;  5J28 A;  4DSY A;  2NXF A;  2Z72 A;  2HYO A;  2O8G A;  3GVE A;  4IYP C;  4LAC C;  5EQV A;  3V4Y A;  2USH A;  4H1S A;  4TUI A;  5F3W A;  2IAE C;  3IVE A;  1QFC A;  4FBW A;  4ORA A;  2NYM C;  4V0W A;  4H2F A;  4ZX2 A;  3DSD A;  1QHW A;  5INB A;  1II7 A;  2DFJ A;  2HYP A;  3H60 A;  3RL3 A;  4LTY A;  4UT3 A;  2XMO A;  3H66 A;  1V73 A;  2YVT A;  3C9F A;  3QFK A;  1UTE A;  4O24 A;  1UF3 A;  3ZTV A;  4FBQ A;  4B2O A;  4NZV A;  1NNW A;  1S95 A;  3C5W C;  3THN A;  1JK7 A;  3H67 A;  4Q7F A;  2AHD A;  3QFM A;  2ZO9 B;  4JA9 A;  2Z1A A;  4KBP A;  4UT2 A;  1TCO A;  3K7W C;  3IVD A;  2HY1 A;  4V0X A;  1FJM A;  4MP0 A;  5C1V A;  3H64 A;  3HVQ A;  4O4K A;  5JPF A;  3EGG A;  4FBK A;  1HO5 A;  1WAR A;  3FLO A;  1MF8 A;  1OIE A;  1G5B A;  2BQ8 X;  3EGH A;  4O5G A;  4MOV A;  2DXL A;  4H1Y P;  3N5U A;  1M63 A;  1KBP A;  4J6O A;  4MOY A;  5JPE A;  3IB7 A;  1XZW A;  2Q8U A;  4XPN A;  1WAO 1;  4I5N C;  3H63 A;  2QFR A;  3ICF A;  3D03 A;  3ZU0 A;  2IE3 C;  1Z2X A;  1USH A;  3RL5 A;  1IT6 A;  3THO B;  2WDD A;  4H2B A;  2WDF A;  2YEQ A;  1T70 A;  3H69 A;  4I5L C;  5GTU A;  1U32 A;  2P6B A;  2R17 A;  4M0V A;  1S8E A;  3K7V C;  2DXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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