4GS7D

Structure of the interleukin-15 quaternary complex
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
67
structure length
67
Chain Sequence
ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Interleukin-15
total genus 14
structure length 67
sequence length 67
ec nomenclature
pdb deposition date 2012-08-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.230 Mainly Beta Single Sheet Rubrerythrin, domain 2 Rubrerythrin, domain 2 4gs7D01
2B5ID 3IU3I 1Z92B 2Z3QB 3NFPI 2Z3RB 2ERSA 2ERJA 2PSMC 4GS7D
chains in the Genus database with same CATH superfamily
2XJSA 1R0FA 2H12A 3LWOB 2WAQP 5IYBL 3GTOL 2M4VA 2ERSA 3RZ6A 1QYBA 2R7ZL 4AHXA 4A3CL 1SFOL 4V196 3HOWL 2EY4E 1K83L 3PWFA 2PSMC 3ZG6A 2C6BA 1T9QA 3P8BA 4C3HL 3FKIL 4BXXL 4U671 3NFPI 4BBSL 1RDVA 2RDVA 3S1RL 2NVQL 2NVXL 1YK5A 1YUZA 1R0IA 4LHNA 3GTKL 2APOB 3HAXC 2Y0SP 1YK4A 3KYVA 1Z92B 3GTPL 4JAFA 3HOYL 4A3GL 1PFYA 4A3FL 2XJQA 1CADA 5M5YL 1YV1A 2E2JL 3VPBE 3PZAA 3S1QL 5C44L 1T9OA 1CAAA 2XJTA 3GTJL 3CQZL 1BQ8A 1R0HA 5EIOC 3KYUA 3H99A 3RZDL 1LKOA 2B5ID 2QL0A 5MGNA 3S16L 2AQCA 4WFN1 1S30A 4ME3A 4A3EL 3MPSA 2V3BB 3K7AL 2E2HL 4AYBP 3HOVL 1PZXA 7RXNA 3HOZL 4A93L 5DM61 1QQTA 1ZRPA 1NXEA 1T9PA 4C2M1 5H1Sc 1TWGL 2E2IL 1BQ9A 5AI2A 4A3DL 5FLML 3RYGA 3PL5A 1R9TL 3B08B 3LPEB 5AI3A 1E8JA 3WWLA 2A68D 4AI1A 4E6YA 2CKCA 2M6PA 1TWHL 3LWVB 3H9BA 1PFWA 4BY1L 3LWRB 1R0GA 2JA8L 2AYJA 3LWQB 2GMGA 3PKIA 3H9CA 1TWAL 2MS3A 2C6AA 5IP7L 4TVMA 2JA7L 2PPTA 4A3JL 2PVEA 3HOXL 3WWNB 1VZIA 3S2DL 4AR4A 2HR5A 3S14L 3S15L 3RZOL 4LHLA 5RXNA 5IP9L 1ODHA 4AHYA 2PMZP 2V0EA 4Y7NL 1RWDA 3IU3I 5JVH1 4AR6A 1OWBA 2PVXA 3S1ML 2ERJA 5K2ME 4C3JL 5M5WL 3A44A 4POGA 2HVYC 3KYYA 4BY7L 2LCQA 1BE7A 5M3FL 4AHWA 3GTML 1B2JA 2Z3RB 3HKZP 2WB1P 3KYXA 4A3BL 1SMUA 5IYDL 5C4JL 3QVDA 4UY81 3H0GL 4AR3A 4AR5A 1PFVA 5GAHc 4C3IL 3GTQL 2VL6A 3PIO1 1OWCA 5IYCL 2O5JD 4B8CD 1B2OA 1IROA 5C4XL 2VUML 2DSXA 1P7PA 2A6HD 2R92L 4GS7D 2V0FA 5MLC3 1WCML 1S24A 2NVTL 3KYWA 1WJVA 1C09A 2XJVA 3GTGL 4AI3A 3PO2L 4RXNA 2YU9L 1LKPA 2XJUA 4A3ML 4XXBB 1NXGA 4X6AL 8RXNA 2M4YA 2A6ED 3PO3L 5AN9H 5MFZA 1B13A 1QCVA 5DM71 3P2AA 5GAGc 5M3ML 4A3IL 2KKDA 1SMWA 4AI0A 2J9UB 1R0JA 3HOUL 2ZIXA 5GADc 1B71A 1NNQA 2NYDA 3SS2A 5IY0A 3JR7A 3HJWB 1JYBA 1RDGA 3QQCE 2BE5D 4QIWP 4ZN3B 3I4NL 2RFKB 4BBRL 1I3QL 2KN9A 2XJRA 1IRNA 1DVBA 2JI2A 5EINC 5MFPA 2Z3QB 6RXNA 3K35A 1H7VA 2M6OA 1SMMA 1DX8A 4POFA 2B63L 4Y52L 2JI3A 1FHMA 3M4OL 1BFYA 1RB9A 4K9FA 3I4ML 2AUSB 1FHHA 1S2ZA 1LTLA 4A3KL 3M3YL 1IU5A 1VZGA 3H3VM 4XGHA 1LKMA 3RZTA 1TWCL 1BRFA 5MF6A 4ZN1B 1I50L 2L0ZA 3H97A 3B0AB 2CKAA 2A69D 2JA5L 5M5XL 4YWLA 3S1NL 5C3EL 3LNLA 1PFUA 1IU6A 4JAGA 3GTLL 4AI2A 3J7Z1 1Y1WL 1RYQA 2XJPA 3MQKB 2CR8A 4JAEA 1RYTA 4G6BA 2JA6L 3S2HL 4YWMA 2NVYL 3PIP1 3PKJA 2JI1A 1VCXA 1TWFL 3LWPB 2PYAA 3HJYB 3S17L 3J7Y1 1Y1VL 4AHZA 2R93L 2K2DA 4A3LL 1YUXA 5GAEc 1I6HL 3FDJA 3MSUA 4JADA 5JVG1 4TPUA 5FJ8L 1VZHA 1F4LA 1IW7D
chains in the Genus database with same CATH topology
4WFN1 1SMUA 2XJSA 1S30A 1H7VA 3QVDA 4ME3A 1R0FA 4UY81 2M6OA 1SMMA 4AR3A 2H12A 4AR5A 1DX8A 4POFA 3MPSA 2M4VA 5GAHc 2JI3A 2ERSA 2V3BB 1FHMA 2VL6A 1QYBA 3RZ6A 7RXNA 1BFYA 5DM61 1RB9A 4K9FA 3PIO1 1OWCA 1FHHA 1S2ZA 4AHXA 1LTLA 2O5JD 4B8CD 1B2OA 1IROA 1IU5A 1VZGA 1ZRPA 2DSXA 1NXEA 1T9PA 5H1Sc 2A6HD 1BQ9A 4GS7D 4XGHA 2V0FA 5AI2A 5MLC3 3RYGA 1LKMA 3RZTA 1S24A 4V196 3B08B 3LPEB 5AI3A 1BRFA 1E8JA 3WWLA 3PWFA 2PSMC 5MF6A 2A68D 4AI1A 4E6YA 4ZN1B 3KYWA 3ZG6A 1WJVA 2L0ZA 2C6BA 2CKCA 2M6PA 3B0AB 2CKAA 2A69D 1C09A 2XJVA 1T9QA 4YWLA 3P8BA 1R0GA 3LNLA 2AYJA 4AI3A 4U671 1IU6A 3NFPI 2GMGA 4JAGA 4AI2A 3PKIA 4RXNA 1RDVA 2RDVA 1LKPA 3J7Z1 2MS3A 2XJUA 2C6AA 4XXBB 1NXGA 1RYQA 2XJPA 1YK5A 2CR8A 4JAEA 4TVMA 1YUZA 1R0IA 4LHNA 1RYTA 2M4YA 2PPTA 8RXNA 2A6ED 5AN9H 2PVEA 4G6BA 3WWNB 1VZIA 5MFZA 1B13A 4AR4A 2HR5A 1QCVA 5DM71 1YK4A 3P2AA 4YWMA 3KYVA 1Z92B 3PIP1 3PKJA 4JAFA 5GAGc 2JI1A 2KKDA 1SMWA 1VCXA 4LHLA 2J9UB 4AI0A 5RXNA 1R0JA 1ODHA 2ZIXA 4AHYA 1B71A 5GADc 2V0EA 1NNQA 2NYDA 2XJQA 1CADA 3SS2A 5IY0A 2PYAA 1YV1A 1JYBA 1RWDA 3IU3I 3J7Y1 5JVH1 3VPBE 3PZAA 1OWBA 4AR6A 2PVXA 1RDGA 4AHZA 2ERJA 2BE5D 1T9OA 3QQCE 4ZN3B 5K2ME 1CAAA 3A44A 4POGA 2KN9A 2XJRA 2XJTA 3KYYA 2LCQA 1IRNA 1BE7A 1BQ8A 2K2DA 1R0HA 1B2JA 4AHWA 5EIOC 1DVBA 3KYUA 1YUXA 2JI2A 5GAEc 1LKOA 2B5ID 5EINC 3MSUA 2QL0A 4JADA 5MFPA 2Z3QB 5JVG1 2Z3RB 5MGNA 6RXNA 3K35A 4TPUA 1VZHA 3KYXA 1IW7D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B5I D;  3IU3 I;  1Z92 B;  2Z3Q B;  3NFP I;  2Z3R B;  2ERS A;  2ERJ A;  2PSM C;  4GS7 D; 
#chains in the Genus database with same CATH topology
 2XJS A;  1R0F A;  2H12 A;  3LWO B;  2WAQ P;  5IYB L;  3GTO L;  2M4V A;  2ERS A;  3RZ6 A;  1QYB A;  2R7Z L;  4AHX A;  4A3C L;  1SFO L;  4V19 6;  3HOW L;  2EY4 E;  1K83 L;  3PWF A;  2PSM C;  3ZG6 A;  2C6B A;  1T9Q A;  3P8B A;  4C3H L;  3FKI L;  4BXX L;  4U67 1;  3NFP I;  4BBS L;  1RDV A;  2RDV A;  3S1R L;  2NVQ L;  2NVX L;  1YK5 A;  1YUZ A;  1R0I A;  4LHN A;  3GTK L;  2APO B;  3HAX C;  2Y0S P;  1YK4 A;  3KYV A;  1Z92 B;  3GTP L;  4JAF A;  3HOY L;  4A3G L;  1PFY A;  4A3F L;  2XJQ A;  1CAD A;  5M5Y L;  1YV1 A;  2E2J L;  3VPB E;  3PZA A;  3S1Q L;  5C44 L;  1T9O A;  1CAA A;  2XJT A;  3GTJ L;  3CQZ L;  1BQ8 A;  1R0H A;  5EIO C;  3KYU A;  3H99 A;  3RZD L;  1LKO A;  2B5I D;  2QL0 A;  5MGN A;  3S16 L;  2AQC A;  4WFN 1;  1S30 A;  4ME3 A;  4A3E L;  3MPS A;  2V3B B;  3K7A L;  2E2H L;  4AYB P;  3HOV L;  1PZX A;  7RXN A;  3HOZ L;  4A93 L;  5DM6 1;  1QQT A;  1ZRP A;  1NXE A;  1T9P A;  4C2M 1;  5H1S c;  1TWG L;  2E2I L;  1BQ9 A;  5AI2 A;  4A3D L;  5FLM L;  3RYG A;  3PL5 A;  1R9T L;  3B08 B;  3LPE B;  5AI3 A;  1E8J A;  3WWL A;  2A68 D;  4AI1 A;  4E6Y A;  2CKC A;  2M6P A;  1TWH L;  3LWV B;  3H9B A;  1PFW A;  4BY1 L;  3LWR B;  1R0G A;  2JA8 L;  2AYJ A;  3LWQ B;  2GMG A;  3PKI A;  3H9C A;  1TWA L;  2MS3 A;  2C6A A;  5IP7 L;  4TVM A;  2JA7 L;  2PPT A;  4A3J L;  2PVE A;  3HOX L;  3WWN B;  1VZI A;  3S2D L;  4AR4 A;  2HR5 A;  3S14 L;  3S15 L;  3RZO L;  4LHL A;  5RXN A;  5IP9 L;  1ODH A;  4AHY A;  2PMZ P;  2V0E A;  4Y7N L;  1RWD A;  3IU3 I;  5JVH 1;  4AR6 A;  1OWB A;  2PVX A;  3S1M L;  2ERJ A;  5K2M E;  4C3J L;  5M5W L;  3A44 A;  4POG A;  2HVY C;  3KYY A;  4BY7 L;  2LCQ A;  1BE7 A;  5M3F L;  4AHW A;  3GTM L;  1B2J A;  2Z3R B;  3HKZ P;  2WB1 P;  3KYX A;  4A3B L;  1SMU A;  5IYD L;  5C4J L;  3QVD A;  4UY8 1;  3H0G L;  4AR3 A;  4AR5 A;  1PFV A;  5GAH c;  4C3I L;  3GTQ L;  2VL6 A;  3PIO 1;  1OWC A;  5IYC L;  2O5J D;  4B8C D;  1B2O A;  1IRO A;  5C4X L;  2VUM L;  2DSX A;  1P7P A;  2A6H D;  2R92 L;  4GS7 D;  2V0F A;  5MLC 3;  1WCM L;  1S24 A;  2NVT L;  3KYW A;  1WJV A;  1C09 A;  2XJV A;  3GTG L;  4AI3 A;  3PO2 L;  4RXN A;  2YU9 L;  1LKP A;  2XJU A;  4A3M L;  4XXB B;  1NXG A;  4X6A L;  8RXN A;  2M4Y A;  2A6E D;  3PO3 L;  5AN9 H;  5MFZ A;  1B13 A;  1QCV A;  5DM7 1;  3P2A A;  5GAG c;  5M3M L;  4A3I L;  2KKD A;  1SMW A;  4AI0 A;  2J9U B;  1R0J A;  3HOU L;  2ZIX A;  5GAD c;  1B71 A;  1NNQ A;  2NYD A;  3SS2 A;  5IY0 A;  3JR7 A;  3HJW B;  1JYB A;  1RDG A;  3QQC E;  2BE5 D;  4QIW P;  4ZN3 B;  3I4N L;  2RFK B;  4BBR L;  1I3Q L;  2KN9 A;  2XJR A;  1IRN A;  1DVB A;  2JI2 A;  5EIN C;  5MFP A;  2Z3Q B;  6RXN A;  3K35 A;  1H7V A;  2M6O A;  1SMM A;  1DX8 A;  4POF A;  2B63 L;  4Y52 L;  2JI3 A;  1FHM A;  3M4O L;  1BFY A;  1RB9 A;  4K9F A;  3I4M L;  2AUS B;  1FHH A;  1S2Z A;  1LTL A;  4A3K L;  3M3Y L;  1IU5 A;  1VZG A;  3H3V M;  4XGH A;  1LKM A;  3RZT A;  1TWC L;  1BRF A;  5MF6 A;  4ZN1 B;  1I50 L;  2L0Z A;  3H97 A;  3B0A B;  2CKA A;  2A69 D;  2JA5 L;  5M5X L;  4YWL A;  3S1N L;  5C3E L;  3LNL A;  1PFU A;  1IU6 A;  4JAG A;  3GTL L;  4AI2 A;  3J7Z 1;  1Y1W L;  1RYQ A;  2XJP A;  3MQK B;  2CR8 A;  4JAE A;  1RYT A;  4G6B A;  2JA6 L;  3S2H L;  4YWM A;  2NVY L;  3PIP 1;  3PKJ A;  2JI1 A;  1VCX A;  1TWF L;  3LWP B;  2PYA A;  3HJY B;  3S17 L;  3J7Y 1;  1Y1V L;  4AHZ A;  2R93 L;  2K2D A;  4A3L L;  1YUX A;  5GAE c;  1I6H L;  3FDJ A;  3MSU A;  4JAD A;  5JVG 1;  4TPU A;  5FJ8 L;  1VZH A;  1F4L A;  1IW7 D; 
#chains in the Genus database with same CATH homology
 4WFN 1;  1SMU A;  2XJS A;  1S30 A;  1H7V A;  3QVD A;  4ME3 A;  1R0F A;  4UY8 1;  2M6O A;  1SMM A;  4AR3 A;  2H12 A;  4AR5 A;  1DX8 A;  4POF A;  3MPS A;  2M4V A;  5GAH c;  2JI3 A;  2ERS A;  2V3B B;  1FHM A;  2VL6 A;  1QYB A;  3RZ6 A;  7RXN A;  1BFY A;  5DM6 1;  1RB9 A;  4K9F A;  3PIO 1;  1OWC A;  1FHH A;  1S2Z A;  4AHX A;  1LTL A;  2O5J D;  4B8C D;  1B2O A;  1IRO A;  1IU5 A;  1VZG A;  1ZRP A;  2DSX A;  1NXE A;  1T9P A;  5H1S c;  2A6H D;  1BQ9 A;  4GS7 D;  4XGH A;  2V0F A;  5AI2 A;  5MLC 3;  3RYG A;  1LKM A;  3RZT A;  1S24 A;  4V19 6;  3B08 B;  3LPE B;  5AI3 A;  1BRF A;  1E8J A;  3WWL A;  3PWF A;  2PSM C;  5MF6 A;  2A68 D;  4AI1 A;  4E6Y A;  4ZN1 B;  3KYW A;  3ZG6 A;  1WJV A;  2L0Z A;  2C6B A;  2CKC A;  2M6P A;  3B0A B;  2CKA A;  2A69 D;  1C09 A;  2XJV A;  1T9Q A;  4YWL A;  3P8B A;  1R0G A;  3LNL A;  2AYJ A;  4AI3 A;  4U67 1;  1IU6 A;  3NFP I;  2GMG A;  4JAG A;  4AI2 A;  3PKI A;  4RXN A;  1RDV A;  2RDV A;  1LKP A;  3J7Z 1;  2MS3 A;  2XJU A;  2C6A A;  4XXB B;  1NXG A;  1RYQ A;  2XJP A;  1YK5 A;  2CR8 A;  4JAE A;  4TVM A;  1YUZ A;  1R0I A;  4LHN A;  1RYT A;  2M4Y A;  2PPT A;  8RXN A;  2A6E D;  5AN9 H;  2PVE A;  4G6B A;  3WWN B;  1VZI A;  5MFZ A;  1B13 A;  4AR4 A;  2HR5 A;  1QCV A;  5DM7 1;  1YK4 A;  3P2A A;  4YWM A;  3KYV A;  1Z92 B;  3PIP 1;  3PKJ A;  4JAF A;  5GAG c;  2JI1 A;  2KKD A;  1SMW A;  1VCX A;  4LHL A;  2J9U B;  4AI0 A;  5RXN A;  1R0J A;  1ODH A;  2ZIX A;  4AHY A;  1B71 A;  5GAD c;  2V0E A;  1NNQ A;  2NYD A;  2XJQ A;  1CAD A;  3SS2 A;  5IY0 A;  2PYA A;  1YV1 A;  1JYB A;  1RWD A;  3IU3 I;  3J7Y 1;  5JVH 1;  3VPB E;  3PZA A;  1OWB A;  4AR6 A;  2PVX A;  1RDG A;  4AHZ A;  2ERJ A;  2BE5 D;  1T9O A;  3QQC E;  4ZN3 B;  5K2M E;  1CAA A;  3A44 A;  4POG A;  2KN9 A;  2XJR A;  2XJT A;  3KYY A;  2LCQ A;  1IRN A;  1BE7 A;  1BQ8 A;  2K2D A;  1R0H A;  1B2J A;  4AHW A;  5EIO C;  1DVB A;  3KYU A;  1YUX A;  2JI2 A;  5GAE c;  1LKO A;  2B5I D;  5EIN C;  3MSU A;  2QL0 A;  4JAD A;  5MFP A;  2Z3Q B;  5JVG 1;  2Z3R B;  5MGN A;  6RXN A;  3K35 A;  4TPU A;  1VZH A;  3KYX A;  1IW7 D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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