4I5LC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
295
structure length
295
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
molecule tags Hydrolase/toxin
source organism Homo sapiens
total genus 111
structure length 295
sequence length 295
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5lC00
3H67A 4I5NC 1S3MA 3E7AA 4KBPA 1XM7A 1XZWA 3HVQA 3AV0A 3P71C 4YKEA 5J28A 4JA7A 3H69A 3RL5A 1T70A 1S8EA 4FBKA 5INBA 4J6OA 3K7VC 2WDFA 1UF3A 3JYFA 1MF8A 1SU1A 2NXFA 4LTYA 1AUIA 2HYOA 3PSNA 3DSCA 4ORBA 3QG5C 3ZTVA 2IE3C 2QJCA 3V4YA 5HPEA 3FGAC 2AHDA 1G5BA 5EQVA 4F0ZA 4G9JA 1W24A 4B2OA 4KKZA 3KBPA 4DHLA 4IYPC 3QFOA 5JPEA 4UT3B 1QFCA 1QHWA 2IE4C 4V0WA 1IT6A 2NYLC 4H2GA 4H1SA 1S95A 2BDXA 2P6BA 4V0VA 4ORCA 4H2IA 3C9FA 4WWLA 4DT2A 1OI8A 2CV9A 4XPNA 2HYPA 1WARA 1U32A 2ZBMA 2WDDA 4FCXA 4DSYA 1S70A 3RL4A 2USHA 4TUIA 3CK2A 2GJUA 4ZX2A 2QFRA 5JJTA 3DSDA 3THNA 2YVTA 4HD0A 1V73A 5C1VA 1JK7A 3RQZA 4O4KA 2BCDA 3ICFA 5F3WA 1TCOA 2JOGA 4OR9A 5IOHA 1Z2XA 1HO5A 2XMOA 3IB7A 3K7WC 3H60A 2KKNA 3QFNA 4UT2A 4O43A 4V0XA 2NPPC 1WAO1 4I5LC 4O24A 2A22A 3QFMA 1M63A 1T71A 1USHA 4FBQA 4H2FA 3ZU0A 3H63A 5B8IA 5GTUA 1UTEA 3E7BA 2WDCA 1FJMA 1S3LA 2IAEC 3H61A 3IB8A 2BQ8X 4M0VA 4ZVZA 5JPFA 3EGGA 4NZVA 2DFJA 4JA9A 3TGHA 3DW8C 1OIEA 3LL8A 3THOB 2QFPA 5DNYA 3N5UA 3EGHA 2R17A 3H62B 4IL1A 3T1IA 2WDEA 3H66A 1OIDA 1II7A 2NYMC 1HP1A 1KBPA 4Q7FA 4FBWA 4MOYA 3RL3A 4MOVA 2O8GA 3IVDA 4ORAA 2HY1A 3AUZA 4LU9A 1Z2WA 3C5WC 3PSOA 4H1YP 4UWQA 3H64A 4UT3A 1NNWA 3H68A 4MP0A 4O5GA 3IVEA 4TUGA 3QFKA 2Z1AA 4LACC 2Z06A 2Q8UA 2Z72A 2O8AA 1HPUA 3GVEA 1S3NA 4H2BA
chains in the Genus database with same CATH superfamily
3H67A 4I5NC 1S3MA 3E7AA 4KBPA 1XM7A 1XZWA 3HVQA 3AV0A 3P71C 4YKEA 5J28A 4JA7A 3H69A 3RL5A 1T70A 1S8EA 4FBKA 5INBA 2YEQA 4J6OA 3K7VC 2WDFA 1UF3A 3JYFA 1MF8A 1SU1A 2NXFA 4LTYA 1AUIA 2HYOA 3PSNA 3DSCA 4ORBA 3QG5C 3ZTVA 2IE3C 2QJCA 3V4YA 5HPEA 3FGAC 2AHDA 1G5BA 5EQVA 4F0ZA 4G9JA 1W24A 4B2OA 4KKZA 3KBPA 4DHLA 4IYPC 3QFOA 5JPEA 4UT3B 1QFCA 1QHWA 2IE4C 4V0WA 1IT6A 2NYLC 4H2GA 4H1SA 1S95A 2BDXA 2P6BA 4V0VA 4ORCA 3D03A 4H2IA 3C9FA 4WWLA 4DT2A 1OI8A 2CV9A 3FLOA 4XPNA 2HYPA 1WARA 1U32A 2ZBMA 2WDDA 4FCXA 4DSYA 1S70A 3RL4A 2USHA 4TUIA 3CK2A 2GJUA 4ZX2A 2QFRA 5JJTA 2DXNA 3THNA 2YVTA 3DSDA 4HD0A 1V73A 5C1VA 1JK7A 3RQZA 4O4KA 2BCDA 3ICFA 5F3WA 1TCOA 2JOGA 2DXLA 4OR9A 5IOHA 1Z2XA 1HO5A 2XMOA 3IB7A 3K7WC 3H60A 2KKNA 3E0JA 3QFNA 4UT2A 4O43A 4V0XA 2NPPC 1WAO1 4I5LC 4O24A 2A22A 3QFMA 1M63A 1T71A 1USHA 4FBQA 4H2FA 3ZU0A 3H63A 5B8IA 5GTUA 1UTEA 3E7BA 2WDCA 1FJMA 1S3LA 2IAEC 3H61A 3IB8A 2BQ8X 4M0VA 4ZVZA 5JPFA 3EGGA 4NZVA 2DFJA 4JA9A 3TGHA 3DW8C 1OIEA 3LL8A 3THOB 2QFPA 5DNYA 3N5UA 3EGHA 2R17A 3H62B 4IL1A 3T1IA 2WDEA 3H66A 1OIDA 1II7A 2NYMC 1HP1A 1KBPA 4Q7FA 4FBWA 4MOYA 3RL3A 4MOVA 2O8GA 3IVDA 4ORAA 2HY1A 2ZOAA 3AUZA 4LU9A 1Z2WA 3C5WC 3PSOA 4H1YP 4UWQA 3H64A 4UT3A 1NNWA 3H68A 4MP0A 4O5GA 3IVEA 4TUGA 3QFKA 2Z1AA 4LACC 2Z06A 2ZO9B 2Q8UA 2Z72A 2O8AA 1HPUA 3GVEA 1S3NA 4H2BA
chains in the Genus database with same CATH topology
3H67A 4I5NC 1S3MA 3E7AA 4KBPA 1XM7A 1XZWA 3HVQA 3AV0A 3P71C 4YKEA 5J28A 4JA7A 3H69A 3RL5A 1T70A 1S8EA 4FBKA 5INBA 2YEQA 4J6OA 3K7VC 2WDFA 1UF3A 3JYFA 1MF8A 1SU1A 2NXFA 4LTYA 1AUIA 2HYOA 3PSNA 3DSCA 4ORBA 3QG5C 3ZTVA 2IE3C 2QJCA 3V4YA 5HPEA 3FGAC 2AHDA 1G5BA 5EQVA 4F0ZA 4G9JA 1W24A 4B2OA 4KKZA 3KBPA 4DHLA 4IYPC 3QFOA 5JPEA 4UT3B 1QFCA 1QHWA 2IE4C 4V0WA 1IT6A 2NYLC 4H2GA 4H1SA 1S95A 2BDXA 2P6BA 4V0VA 4ORCA 3D03A 4H2IA 3C9FA 4WWLA 4DT2A 1OI8A 2CV9A 3FLOA 4XPNA 2HYPA 1WARA 1U32A 2ZBMA 2WDDA 4FCXA 4DSYA 1S70A 3RL4A 2USHA 4TUIA 3CK2A 2GJUA 4ZX2A 2QFRA 5JJTA 2DXNA 3THNA 2YVTA 3DSDA 4HD0A 1V73A 5C1VA 1JK7A 3RQZA 4O4KA 2BCDA 3ICFA 5F3WA 1TCOA 2JOGA 2DXLA 4OR9A 5IOHA 1Z2XA 1HO5A 2XMOA 3IB7A 3K7WC 3H60A 2KKNA 3E0JA 3QFNA 4UT2A 4O43A 4V0XA 2NPPC 1WAO1 4I5LC 4O24A 2A22A 3QFMA 1M63A 1T71A 1USHA 4FBQA 4H2FA 3ZU0A 3H63A 5B8IA 5GTUA 1UTEA 3E7BA 2WDCA 1FJMA 1S3LA 2IAEC 3H61A 3IB8A 2BQ8X 4M0VA 4ZVZA 5JPFA 3EGGA 4NZVA 2DFJA 4JA9A 3TGHA 3DW8C 1OIEA 3LL8A 3THOB 2QFPA 5DNYA 3N5UA 3EGHA 2R17A 3H62B 4IL1A 3T1IA 2WDEA 3H66A 1OIDA 1II7A 2NYMC 1HP1A 1KBPA 4Q7FA 4FBWA 4MOYA 3RL3A 4MOVA 2O8GA 3IVDA 4ORAA 2HY1A 2ZOAA 3AUZA 4LU9A 1Z2WA 3C5WC 3PSOA 4H1YP 4UWQA 3H64A 4UT3A 1NNWA 3H68A 4MP0A 4O5GA 3IVEA 4TUGA 3QFKA 2Z1AA 4LACC 2Z06A 2ZO9B 2Q8UA 2Z72A 2O8AA 1HPUA 3GVEA 1S3NA 4H2BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H67 A;  4I5N C;  1S3M A;  3E7A A;  4KBP A;  1XM7 A;  1XZW A;  3HVQ A;  3AV0 A;  3P71 C;  4YKE A;  5J28 A;  4JA7 A;  3H69 A;  3RL5 A;  1T70 A;  1S8E A;  4FBK A;  5INB A;  4J6O A;  3K7V C;  2WDF A;  1UF3 A;  3JYF A;  1MF8 A;  1SU1 A;  2NXF A;  4LTY A;  1AUI A;  2HYO A;  3PSN A;  3DSC A;  4ORB A;  3QG5 C;  3ZTV A;  2IE3 C;  2QJC A;  3V4Y A;  5HPE A;  3FGA C;  2AHD A;  1G5B A;  5EQV A;  4F0Z A;  4G9J A;  1W24 A;  4B2O A;  4KKZ A;  3KBP A;  4DHL A;  4IYP C;  3QFO A;  5JPE A;  4UT3 B;  1QFC A;  1QHW A;  2IE4 C;  4V0W A;  1IT6 A;  2NYL C;  4H2G A;  4H1S A;  1S95 A;  2BDX A;  2P6B A;  4V0V A;  4ORC A;  4H2I A;  3C9F A;  4WWL A;  4DT2 A;  1OI8 A;  2CV9 A;  4XPN A;  2HYP A;  1WAR A;  1U32 A;  2ZBM A;  2WDD A;  4FCX A;  4DSY A;  1S70 A;  3RL4 A;  2USH A;  4TUI A;  3CK2 A;  2GJU A;  4ZX2 A;  2QFR A;  5JJT A;  3DSD A;  3THN A;  2YVT A;  4HD0 A;  1V73 A;  5C1V A;  1JK7 A;  3RQZ A;  4O4K A;  2BCD A;  3ICF A;  5F3W A;  1TCO A;  2JOG A;  4OR9 A;  5IOH A;  1Z2X A;  1HO5 A;  2XMO A;  3IB7 A;  3K7W C;  3H60 A;  2KKN A;  3QFN A;  4UT2 A;  4O43 A;  4V0X A;  2NPP C;  1WAO 1;  4I5L C;  4O24 A;  2A22 A;  3QFM A;  1M63 A;  1T71 A;  1USH A;  4FBQ A;  4H2F A;  3ZU0 A;  3H63 A;  5B8I A;  5GTU A;  1UTE A;  3E7B A;  2WDC A;  1FJM A;  1S3L A;  2IAE C;  3H61 A;  3IB8 A;  2BQ8 X;  4M0V A;  4ZVZ A;  5JPF A;  3EGG A;  4NZV A;  2DFJ A;  4JA9 A;  3TGH A;  3DW8 C;  1OIE A;  3LL8 A;  3THO B;  2QFP A;  5DNY A;  3N5U A;  3EGH A;  2R17 A;  3H62 B;  4IL1 A;  3T1I A;  2WDE A;  3H66 A;  1OID A;  1II7 A;  2NYM C;  1HP1 A;  1KBP A;  4Q7F A;  4FBW A;  4MOY A;  3RL3 A;  4MOV A;  2O8G A;  3IVD A;  4ORA A;  2HY1 A;  3AUZ A;  4LU9 A;  1Z2W A;  3C5W C;  3PSO A;  4H1Y P;  4UWQ A;  3H64 A;  4UT3 A;  1NNW A;  3H68 A;  4MP0 A;  4O5G A;  3IVE A;  4TUG A;  3QFK A;  2Z1A A;  4LAC C;  2Z06 A;  2Q8U A;  2Z72 A;  2O8A A;  1HPU A;  3GVE A;  1S3N A;  4H2B A; 
#chains in the Genus database with same CATH topology
 3H67 A;  4I5N C;  1S3M A;  3E7A A;  4KBP A;  1XM7 A;  1XZW A;  3HVQ A;  3AV0 A;  3P71 C;  4YKE A;  5J28 A;  4JA7 A;  3H69 A;  3RL5 A;  1T70 A;  1S8E A;  4FBK A;  5INB A;  2YEQ A;  4J6O A;  3K7V C;  2WDF A;  1UF3 A;  3JYF A;  1MF8 A;  1SU1 A;  2NXF A;  4LTY A;  1AUI A;  2HYO A;  3PSN A;  3DSC A;  4ORB A;  3QG5 C;  3ZTV A;  2IE3 C;  2QJC A;  3V4Y A;  5HPE A;  3FGA C;  2AHD A;  1G5B A;  5EQV A;  4F0Z A;  4G9J A;  1W24 A;  4B2O A;  4KKZ A;  3KBP A;  4DHL A;  4IYP C;  3QFO A;  5JPE A;  4UT3 B;  1QFC A;  1QHW A;  2IE4 C;  4V0W A;  1IT6 A;  2NYL C;  4H2G A;  4H1S A;  1S95 A;  2BDX A;  2P6B A;  4V0V A;  4ORC A;  3D03 A;  4H2I A;  3C9F A;  4WWL A;  4DT2 A;  1OI8 A;  2CV9 A;  3FLO A;  4XPN A;  2HYP A;  1WAR A;  1U32 A;  2ZBM A;  2WDD A;  4FCX A;  4DSY A;  1S70 A;  3RL4 A;  2USH A;  4TUI A;  3CK2 A;  2GJU A;  4ZX2 A;  2QFR A;  5JJT A;  2DXN A;  3THN A;  2YVT A;  3DSD A;  4HD0 A;  1V73 A;  5C1V A;  1JK7 A;  3RQZ A;  4O4K A;  2BCD A;  3ICF A;  5F3W A;  1TCO A;  2JOG A;  2DXL A;  4OR9 A;  5IOH A;  1Z2X A;  1HO5 A;  2XMO A;  3IB7 A;  3K7W C;  3H60 A;  2KKN A;  3E0J A;  3QFN A;  4UT2 A;  4O43 A;  4V0X A;  2NPP C;  1WAO 1;  4I5L C;  4O24 A;  2A22 A;  3QFM A;  1M63 A;  1T71 A;  1USH A;  4FBQ A;  4H2F A;  3ZU0 A;  3H63 A;  5B8I A;  5GTU A;  1UTE A;  3E7B A;  2WDC A;  1FJM A;  1S3L A;  2IAE C;  3H61 A;  3IB8 A;  2BQ8 X;  4M0V A;  4ZVZ A;  5JPF A;  3EGG A;  4NZV A;  2DFJ A;  4JA9 A;  3TGH A;  3DW8 C;  1OIE A;  3LL8 A;  3THO B;  2QFP A;  5DNY A;  3N5U A;  3EGH A;  2R17 A;  3H62 B;  4IL1 A;  3T1I A;  2WDE A;  3H66 A;  1OID A;  1II7 A;  2NYM C;  1HP1 A;  1KBP A;  4Q7F A;  4FBW A;  4MOY A;  3RL3 A;  4MOV A;  2O8G A;  3IVD A;  4ORA A;  2HY1 A;  2ZOA A;  3AUZ A;  4LU9 A;  1Z2W A;  3C5W C;  3PSO A;  4H1Y P;  4UWQ A;  3H64 A;  4UT3 A;  1NNW A;  3H68 A;  4MP0 A;  4O5G A;  3IVE A;  4TUG A;  3QFK A;  2Z1A A;  4LAC C;  2Z06 A;  2ZO9 B;  2Q8U A;  2Z72 A;  2O8A A;  1HPU A;  3GVE A;  1S3N A;  4H2B A; 
#chains in the Genus database with same CATH homology
 3H67 A;  4I5N C;  1S3M A;  3E7A A;  4KBP A;  1XM7 A;  1XZW A;  3HVQ A;  3AV0 A;  3P71 C;  4YKE A;  5J28 A;  4JA7 A;  3H69 A;  3RL5 A;  1T70 A;  1S8E A;  4FBK A;  5INB A;  2YEQ A;  4J6O A;  3K7V C;  2WDF A;  1UF3 A;  3JYF A;  1MF8 A;  1SU1 A;  2NXF A;  4LTY A;  1AUI A;  2HYO A;  3PSN A;  3DSC A;  4ORB A;  3QG5 C;  3ZTV A;  2IE3 C;  2QJC A;  3V4Y A;  5HPE A;  3FGA C;  2AHD A;  1G5B A;  5EQV A;  4F0Z A;  4G9J A;  1W24 A;  4B2O A;  4KKZ A;  3KBP A;  4DHL A;  4IYP C;  3QFO A;  5JPE A;  4UT3 B;  1QFC A;  1QHW A;  2IE4 C;  4V0W A;  1IT6 A;  2NYL C;  4H2G A;  4H1S A;  1S95 A;  2BDX A;  2P6B A;  4V0V A;  4ORC A;  3D03 A;  4H2I A;  3C9F A;  4WWL A;  4DT2 A;  1OI8 A;  2CV9 A;  3FLO A;  4XPN A;  2HYP A;  1WAR A;  1U32 A;  2ZBM A;  2WDD A;  4FCX A;  4DSY A;  1S70 A;  3RL4 A;  2USH A;  4TUI A;  3CK2 A;  2GJU A;  4ZX2 A;  2QFR A;  5JJT A;  2DXN A;  3THN A;  2YVT A;  3DSD A;  4HD0 A;  1V73 A;  5C1V A;  1JK7 A;  3RQZ A;  4O4K A;  2BCD A;  3ICF A;  5F3W A;  1TCO A;  2JOG A;  2DXL A;  4OR9 A;  5IOH A;  1Z2X A;  1HO5 A;  2XMO A;  3IB7 A;  3K7W C;  3H60 A;  2KKN A;  3E0J A;  3QFN A;  4UT2 A;  4O43 A;  4V0X A;  2NPP C;  1WAO 1;  4I5L C;  4O24 A;  2A22 A;  3QFM A;  1M63 A;  1T71 A;  1USH A;  4FBQ A;  4H2F A;  3ZU0 A;  3H63 A;  5B8I A;  5GTU A;  1UTE A;  3E7B A;  2WDC A;  1FJM A;  1S3L A;  2IAE C;  3H61 A;  3IB8 A;  2BQ8 X;  4M0V A;  4ZVZ A;  5JPF A;  3EGG A;  4NZV A;  2DFJ A;  4JA9 A;  3TGH A;  3DW8 C;  1OIE A;  3LL8 A;  3THO B;  2QFP A;  5DNY A;  3N5U A;  3EGH A;  2R17 A;  3H62 B;  4IL1 A;  3T1I A;  2WDE A;  3H66 A;  1OID A;  1II7 A;  2NYM C;  1HP1 A;  1KBP A;  4Q7F A;  4FBW A;  4MOY A;  3RL3 A;  4MOV A;  2O8G A;  3IVD A;  4ORA A;  2HY1 A;  2ZOA A;  3AUZ A;  4LU9 A;  1Z2W A;  3C5W C;  3PSO A;  4H1Y P;  4UWQ A;  3H64 A;  4UT3 A;  1NNW A;  3H68 A;  4MP0 A;  4O5G A;  3IVE A;  4TUG A;  3QFK A;  2Z1A A;  4LAC C;  2Z06 A;  2ZO9 B;  2Q8U A;  2Z72 A;  2O8A A;  1HPU A;  3GVE A;  1S3N A;  4H2B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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