4I5NC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/toxin
source organism Homo sapiens
publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 104
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5nC00
2QFPA 2BQ8X 3KBPA 4I5LC 3RL4A 4ORCA 3RQZA 1AUIA 2WDCA 4H2BA 4DSYA 4F0ZA 3QFKA 1T71A 1Z2XA 3IVEA 3IB7A 1UF3A 1M63A 1KBPA 3H68A 4IL1A 2CV9A 1HP1A 2Z06A 2HYPA 5C1VA 2A22A 4TUIA 1WAO1 2XMOA 2HY1A 4O43A 4JA9A 5HPEA 3H66A 4ORAA 2GJUA 1II7A 1HO5A 4KBPA 4DHLA 4FBWA 3THOB 3V4YA 2IE3C 1XZWA 1XM7A 4V0XA 3EGGA 5INBA 3AUZA 3TGHA 1QFCA 5EQVA 3H60A 3PSOA 4UT3A 4HD0A 4NZVA 1S3LA 3ZU0A 3AV0A 1V73A 1G5BA 4DT2A 4V0WA 4O4KA 2R17A 2NXFA 2NYMC 1S3NA 4FBQA 3PSNA 5JJTA 2WDFA 2Z1AA 1HPUA 3CK2A 4OR9A 4MOVA 2BCDA 5B8IA 1JK7A 3H63A 5GTUA 3GVEA 4FCXA 4J6OA 4TUGA 3E7AA 1NNWA 4ZVZA 4LACC 4O5GA 4UT3B 1Z2WA 2YVTA 3H67A 3QFNA 3RL5A 4YKEA 4I5NC 1S70A 4B2OA 2Z72A 2WDDA 5DNYA 2O8GA 1S95A 4H2IA 3DSDA 3EGHA 4XPNA 2AHDA 4LU9A 4IYPC 3THNA 1OIDA 4UWQA 2WDEA 1TCOA 2NYLC 3T1IA 3IVDA 1WARA 1UTEA 3C5WC 4KKZA 3FGAC 3DSCA 1QHWA 4ORBA 3H69A 3P71C 1FJMA 3QFMA 2KKNA 5JPEA 3LL8A 5F3WA 2HYOA 3IB8A 1SU1A 2Q8UA 4WWLA 2IAEC 2JOGA 3N5UA 2BDXA 2IE4C 1S3MA 4M0VA 4H2GA 4H1SA 4MOYA 3JYFA 4ZX2A 5JPFA 4V0VA 2QJCA 1U32A 4H1YP 1USHA 1T70A 2QFRA 2DFJA 3ICFA 4MP0A 1W24A 5IOHA 1OIEA 2P6BA 2ZBMA 3H61A 3QG5C 1MF8A 4H2FA 2O8AA 3H64A 3QFOA 3C9FA 3RL3A 4O24A 3H62B 4G9JA 2USHA 3DW8C 4UT2A 3ZTVA 4LTYA 1OI8A 1S8EA 3E7BA 3HVQA 3K7WC 2NPPC 1IT6A 3K7VC 4FBKA 4Q7FA 5J28A 4JA7A
chains in the Genus database with same CATH superfamily
2QFPA 2BQ8X 3KBPA 4I5LC 3RL4A 4ORCA 3RQZA 1AUIA 2WDCA 4H2BA 4DSYA 4F0ZA 3QFKA 1T71A 1Z2XA 3IVEA 3D03A 3IB7A 1UF3A 1M63A 1KBPA 3H68A 4IL1A 2CV9A 1HP1A 2Z06A 2HYPA 5C1VA 2A22A 4TUIA 2DXLA 1WAO1 2XMOA 2HY1A 4O43A 2YEQA 2ZOAA 4JA9A 5HPEA 3H66A 4ORAA 2GJUA 1II7A 1HO5A 4KBPA 4DHLA 4FBWA 3THOB 3V4YA 2IE3C 1XZWA 1XM7A 4V0XA 3EGGA 5INBA 3AUZA 3TGHA 1QFCA 5EQVA 3H60A 3PSOA 4UT3A 4HD0A 4NZVA 1S3LA 3ZU0A 3AV0A 1V73A 1G5BA 4DT2A 4V0WA 4O4KA 2R17A 2NXFA 2NYMC 1S3NA 4FBQA 3PSNA 2ZO9B 2WDFA 2Z1AA 5JJTA 1HPUA 3CK2A 4OR9A 3E0JA 2BCDA 4MOVA 5B8IA 1JK7A 3H63A 5GTUA 3GVEA 4FCXA 4J6OA 4TUGA 3E7AA 1NNWA 4ZVZA 4LACC 4O5GA 4UT3B 1Z2WA 2YVTA 3H67A 3QFNA 3RL5A 4YKEA 4I5NC 1S70A 4B2OA 2Z72A 2WDDA 5DNYA 2O8GA 1S95A 4H2IA 3DSDA 3EGHA 4XPNA 2AHDA 4LU9A 4IYPC 3THNA 1OIDA 4UWQA 2WDEA 1TCOA 2NYLC 3T1IA 3IVDA 1WARA 1UTEA 3C5WC 4KKZA 3FGAC 3FLOA 3DSCA 1QHWA 4ORBA 3H69A 3P71C 1FJMA 3QFMA 2KKNA 5JPEA 3LL8A 5F3WA 2HYOA 3IB8A 1SU1A 2Q8UA 4WWLA 2IAEC 2JOGA 3N5UA 2BDXA 2IE4C 1S3MA 4M0VA 4H2GA 4H1SA 4MOYA 3JYFA 4ZX2A 5JPFA 4V0VA 2QJCA 1U32A 4H1YP 1USHA 1T70A 2QFRA 2DFJA 3ICFA 4MP0A 1W24A 5IOHA 1OIEA 2P6BA 2ZBMA 3H61A 3QG5C 1MF8A 4H2FA 2O8AA 3H64A 3QFOA 3C9FA 3RL3A 4O24A 3H62B 4G9JA 2USHA 3DW8C 4UT2A 3ZTVA 4LTYA 1OI8A 1S8EA 2DXNA 3E7BA 3HVQA 3K7WC 2NPPC 1IT6A 3K7VC 4FBKA 4Q7FA 5J28A 4JA7A
chains in the Genus database with same CATH topology
2QFPA 2BQ8X 3KBPA 4I5LC 3RL4A 4ORCA 3RQZA 1AUIA 2WDCA 4H2BA 4DSYA 4F0ZA 3QFKA 1T71A 1Z2XA 3IVEA 3D03A 3IB7A 1UF3A 1M63A 1KBPA 3H68A 4IL1A 2CV9A 1HP1A 2Z06A 2HYPA 5C1VA 2A22A 4TUIA 2DXLA 1WAO1 2XMOA 2HY1A 4O43A 2YEQA 2ZOAA 4JA9A 5HPEA 3H66A 4ORAA 2GJUA 1II7A 1HO5A 4KBPA 4DHLA 4FBWA 3THOB 3V4YA 2IE3C 1XZWA 1XM7A 4V0XA 3EGGA 5INBA 3AUZA 3TGHA 1QFCA 5EQVA 3H60A 3PSOA 4UT3A 4HD0A 4NZVA 1S3LA 3ZU0A 3AV0A 1V73A 1G5BA 4DT2A 4V0WA 4O4KA 2R17A 2NXFA 2NYMC 1S3NA 4FBQA 3PSNA 2ZO9B 2WDFA 2Z1AA 5JJTA 1HPUA 3CK2A 4OR9A 3E0JA 2BCDA 4MOVA 5B8IA 1JK7A 3H63A 5GTUA 3GVEA 4FCXA 4J6OA 4TUGA 3E7AA 1NNWA 4ZVZA 4LACC 4O5GA 4UT3B 1Z2WA 2YVTA 3H67A 3QFNA 3RL5A 4YKEA 4I5NC 1S70A 4B2OA 2Z72A 2WDDA 5DNYA 2O8GA 1S95A 4H2IA 3DSDA 3EGHA 4XPNA 2AHDA 4LU9A 4IYPC 3THNA 1OIDA 4UWQA 2WDEA 1TCOA 2NYLC 3T1IA 3IVDA 1WARA 1UTEA 3C5WC 4KKZA 3FGAC 3FLOA 3DSCA 1QHWA 4ORBA 3H69A 3P71C 1FJMA 3QFMA 2KKNA 5JPEA 3LL8A 5F3WA 2HYOA 3IB8A 1SU1A 2Q8UA 4WWLA 2IAEC 2JOGA 3N5UA 2BDXA 2IE4C 1S3MA 4M0VA 4H2GA 4H1SA 4MOYA 3JYFA 4ZX2A 5JPFA 4V0VA 2QJCA 1U32A 4H1YP 1USHA 1T70A 2QFRA 2DFJA 3ICFA 4MP0A 1W24A 5IOHA 1OIEA 2P6BA 2ZBMA 3H61A 3QG5C 1MF8A 4H2FA 2O8AA 3H64A 3QFOA 3C9FA 3RL3A 4O24A 3H62B 4G9JA 2USHA 3DW8C 4UT2A 3ZTVA 4LTYA 1OI8A 1S8EA 2DXNA 3E7BA 3HVQA 3K7WC 2NPPC 1IT6A 3K7VC 4FBKA 4Q7FA 5J28A 4JA7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QFP A;  2BQ8 X;  3KBP A;  4I5L C;  3RL4 A;  4ORC A;  3RQZ A;  1AUI A;  2WDC A;  4H2B A;  4DSY A;  4F0Z A;  3QFK A;  1T71 A;  1Z2X A;  3IVE A;  3IB7 A;  1UF3 A;  1M63 A;  1KBP A;  3H68 A;  4IL1 A;  2CV9 A;  1HP1 A;  2Z06 A;  2HYP A;  5C1V A;  2A22 A;  4TUI A;  1WAO 1;  2XMO A;  2HY1 A;  4O43 A;  4JA9 A;  5HPE A;  3H66 A;  4ORA A;  2GJU A;  1II7 A;  1HO5 A;  4KBP A;  4DHL A;  4FBW A;  3THO B;  3V4Y A;  2IE3 C;  1XZW A;  1XM7 A;  4V0X A;  3EGG A;  5INB A;  3AUZ A;  3TGH A;  1QFC A;  5EQV A;  3H60 A;  3PSO A;  4UT3 A;  4HD0 A;  4NZV A;  1S3L A;  3ZU0 A;  3AV0 A;  1V73 A;  1G5B A;  4DT2 A;  4V0W A;  4O4K A;  2R17 A;  2NXF A;  2NYM C;  1S3N A;  4FBQ A;  3PSN A;  5JJT A;  2WDF A;  2Z1A A;  1HPU A;  3CK2 A;  4OR9 A;  4MOV A;  2BCD A;  5B8I A;  1JK7 A;  3H63 A;  5GTU A;  3GVE A;  4FCX A;  4J6O A;  4TUG A;  3E7A A;  1NNW A;  4ZVZ A;  4LAC C;  4O5G A;  4UT3 B;  1Z2W A;  2YVT A;  3H67 A;  3QFN A;  3RL5 A;  4YKE A;  4I5N C;  1S70 A;  4B2O A;  2Z72 A;  2WDD A;  5DNY A;  2O8G A;  1S95 A;  4H2I A;  3DSD A;  3EGH A;  4XPN A;  2AHD A;  4LU9 A;  4IYP C;  3THN A;  1OID A;  4UWQ A;  2WDE A;  1TCO A;  2NYL C;  3T1I A;  3IVD A;  1WAR A;  1UTE A;  3C5W C;  4KKZ A;  3FGA C;  3DSC A;  1QHW A;  4ORB A;  3H69 A;  3P71 C;  1FJM A;  3QFM A;  2KKN A;  5JPE A;  3LL8 A;  5F3W A;  2HYO A;  3IB8 A;  1SU1 A;  2Q8U A;  4WWL A;  2IAE C;  2JOG A;  3N5U A;  2BDX A;  2IE4 C;  1S3M A;  4M0V A;  4H2G A;  4H1S A;  4MOY A;  3JYF A;  4ZX2 A;  5JPF A;  4V0V A;  2QJC A;  1U32 A;  4H1Y P;  1USH A;  1T70 A;  2QFR A;  2DFJ A;  3ICF A;  4MP0 A;  1W24 A;  5IOH A;  1OIE A;  2P6B A;  2ZBM A;  3H61 A;  3QG5 C;  1MF8 A;  4H2F A;  2O8A A;  3H64 A;  3QFO A;  3C9F A;  3RL3 A;  4O24 A;  3H62 B;  4G9J A;  2USH A;  3DW8 C;  4UT2 A;  3ZTV A;  4LTY A;  1OI8 A;  1S8E A;  3E7B A;  3HVQ A;  3K7W C;  2NPP C;  1IT6 A;  3K7V C;  4FBK A;  4Q7F A;  5J28 A;  4JA7 A; 
#chains in the Genus database with same CATH topology
 2QFP A;  2BQ8 X;  3KBP A;  4I5L C;  3RL4 A;  4ORC A;  3RQZ A;  1AUI A;  2WDC A;  4H2B A;  4DSY A;  4F0Z A;  3QFK A;  1T71 A;  1Z2X A;  3IVE A;  3D03 A;  3IB7 A;  1UF3 A;  1M63 A;  1KBP A;  3H68 A;  4IL1 A;  2CV9 A;  1HP1 A;  2Z06 A;  2HYP A;  5C1V A;  2A22 A;  4TUI A;  2DXL A;  1WAO 1;  2XMO A;  2HY1 A;  4O43 A;  2YEQ A;  2ZOA A;  4JA9 A;  5HPE A;  3H66 A;  4ORA A;  2GJU A;  1II7 A;  1HO5 A;  4KBP A;  4DHL A;  4FBW A;  3THO B;  3V4Y A;  2IE3 C;  1XZW A;  1XM7 A;  4V0X A;  3EGG A;  5INB A;  3AUZ A;  3TGH A;  1QFC A;  5EQV A;  3H60 A;  3PSO A;  4UT3 A;  4HD0 A;  4NZV A;  1S3L A;  3ZU0 A;  3AV0 A;  1V73 A;  1G5B A;  4DT2 A;  4V0W A;  4O4K A;  2R17 A;  2NXF A;  2NYM C;  1S3N A;  4FBQ A;  3PSN A;  2ZO9 B;  2WDF A;  2Z1A A;  5JJT A;  1HPU A;  3CK2 A;  4OR9 A;  3E0J A;  2BCD A;  4MOV A;  5B8I A;  1JK7 A;  3H63 A;  5GTU A;  3GVE A;  4FCX A;  4J6O A;  4TUG A;  3E7A A;  1NNW A;  4ZVZ A;  4LAC C;  4O5G A;  4UT3 B;  1Z2W A;  2YVT A;  3H67 A;  3QFN A;  3RL5 A;  4YKE A;  4I5N C;  1S70 A;  4B2O A;  2Z72 A;  2WDD A;  5DNY A;  2O8G A;  1S95 A;  4H2I A;  3DSD A;  3EGH A;  4XPN A;  2AHD A;  4LU9 A;  4IYP C;  3THN A;  1OID A;  4UWQ A;  2WDE A;  1TCO A;  2NYL C;  3T1I A;  3IVD A;  1WAR A;  1UTE A;  3C5W C;  4KKZ A;  3FGA C;  3FLO A;  3DSC A;  1QHW A;  4ORB A;  3H69 A;  3P71 C;  1FJM A;  3QFM A;  2KKN A;  5JPE A;  3LL8 A;  5F3W A;  2HYO A;  3IB8 A;  1SU1 A;  2Q8U A;  4WWL A;  2IAE C;  2JOG A;  3N5U A;  2BDX A;  2IE4 C;  1S3M A;  4M0V A;  4H2G A;  4H1S A;  4MOY A;  3JYF A;  4ZX2 A;  5JPF A;  4V0V A;  2QJC A;  1U32 A;  4H1Y P;  1USH A;  1T70 A;  2QFR A;  2DFJ A;  3ICF A;  4MP0 A;  1W24 A;  5IOH A;  1OIE A;  2P6B A;  2ZBM A;  3H61 A;  3QG5 C;  1MF8 A;  4H2F A;  2O8A A;  3H64 A;  3QFO A;  3C9F A;  3RL3 A;  4O24 A;  3H62 B;  4G9J A;  2USH A;  3DW8 C;  4UT2 A;  3ZTV A;  4LTY A;  1OI8 A;  1S8E A;  2DXN A;  3E7B A;  3HVQ A;  3K7W C;  2NPP C;  1IT6 A;  3K7V C;  4FBK A;  4Q7F A;  5J28 A;  4JA7 A; 
#chains in the Genus database with same CATH homology
 2QFP A;  2BQ8 X;  3KBP A;  4I5L C;  3RL4 A;  4ORC A;  3RQZ A;  1AUI A;  2WDC A;  4H2B A;  4DSY A;  4F0Z A;  3QFK A;  1T71 A;  1Z2X A;  3IVE A;  3D03 A;  3IB7 A;  1UF3 A;  1M63 A;  1KBP A;  3H68 A;  4IL1 A;  2CV9 A;  1HP1 A;  2Z06 A;  2HYP A;  5C1V A;  2A22 A;  4TUI A;  2DXL A;  1WAO 1;  2XMO A;  2HY1 A;  4O43 A;  2YEQ A;  2ZOA A;  4JA9 A;  5HPE A;  3H66 A;  4ORA A;  2GJU A;  1II7 A;  1HO5 A;  4KBP A;  4DHL A;  4FBW A;  3THO B;  3V4Y A;  2IE3 C;  1XZW A;  1XM7 A;  4V0X A;  3EGG A;  5INB A;  3AUZ A;  3TGH A;  1QFC A;  5EQV A;  3H60 A;  3PSO A;  4UT3 A;  4HD0 A;  4NZV A;  1S3L A;  3ZU0 A;  3AV0 A;  1V73 A;  1G5B A;  4DT2 A;  4V0W A;  4O4K A;  2R17 A;  2NXF A;  2NYM C;  1S3N A;  4FBQ A;  3PSN A;  2ZO9 B;  2WDF A;  2Z1A A;  5JJT A;  1HPU A;  3CK2 A;  4OR9 A;  3E0J A;  2BCD A;  4MOV A;  5B8I A;  1JK7 A;  3H63 A;  5GTU A;  3GVE A;  4FCX A;  4J6O A;  4TUG A;  3E7A A;  1NNW A;  4ZVZ A;  4LAC C;  4O5G A;  4UT3 B;  1Z2W A;  2YVT A;  3H67 A;  3QFN A;  3RL5 A;  4YKE A;  4I5N C;  1S70 A;  4B2O A;  2Z72 A;  2WDD A;  5DNY A;  2O8G A;  1S95 A;  4H2I A;  3DSD A;  3EGH A;  4XPN A;  2AHD A;  4LU9 A;  4IYP C;  3THN A;  1OID A;  4UWQ A;  2WDE A;  1TCO A;  2NYL C;  3T1I A;  3IVD A;  1WAR A;  1UTE A;  3C5W C;  4KKZ A;  3FGA C;  3FLO A;  3DSC A;  1QHW A;  4ORB A;  3H69 A;  3P71 C;  1FJM A;  3QFM A;  2KKN A;  5JPE A;  3LL8 A;  5F3W A;  2HYO A;  3IB8 A;  1SU1 A;  2Q8U A;  4WWL A;  2IAE C;  2JOG A;  3N5U A;  2BDX A;  2IE4 C;  1S3M A;  4M0V A;  4H2G A;  4H1S A;  4MOY A;  3JYF A;  4ZX2 A;  5JPF A;  4V0V A;  2QJC A;  1U32 A;  4H1Y P;  1USH A;  1T70 A;  2QFR A;  2DFJ A;  3ICF A;  4MP0 A;  1W24 A;  5IOH A;  1OIE A;  2P6B A;  2ZBM A;  3H61 A;  3QG5 C;  1MF8 A;  4H2F A;  2O8A A;  3H64 A;  3QFO A;  3C9F A;  3RL3 A;  4O24 A;  3H62 B;  4G9J A;  2USH A;  3DW8 C;  4UT2 A;  3ZTV A;  4LTY A;  1OI8 A;  1S8E A;  2DXN A;  3E7B A;  3HVQ A;  3K7W C;  2NPP C;  1IT6 A;  3K7V C;  4FBK A;  4Q7F A;  5J28 A;  4JA7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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