4MP0A

Structure of a second nuclear pp1 holoenzyme, crystal form 2
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
295
structure length
295
Chain Sequence
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 111
structure length 295
sequence length 295
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2013-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4mp0A00
3CK2A 3ZTVA 5JJTA 4H2BA 1HPUA 4V0WA 2BCDA 3IB8A 2ZBMA 3QG5C 1JK7A 4TUGA 2WDEA 1T70A 3QFMA 3DSCA 1S8EA 4OR9A 1NNWA 3IVDA 4O4KA 4V0XA 3E7BA 4FBWA 4I5LC 3H69A 4O5GA 2IAEC 4H1SA 1MF8A 3DSDA 3EGHA 1S70A 1QHWA 2IE3C 2P6BA 4O24A 4JA9A 2Z06A 5HPEA 4WWLA 4TUIA 4G9JA 2HYPA 1S3NA 4ORBA 2JOGA 3TGHA 5C1VA 3QFKA 3EGGA 1S95A 4UT2A 1S3MA 2KKNA 1M63A 4H2GA 1USHA 4FBQA 4UWQA 5GTUA 1HO5A 1TCOA 1V73A 3ZU0A 2HY1A 5F3WA 2WDDA 4FCXA 3GVEA 2A22A 3LL8A 4UT3A 1U32A 4DT2A 2AHDA 2HYOA 1Z2XA 4F0ZA 1G5BA 1UF3A 1XM7A 2O8GA 1WAO1 4LU9A 3RL4A 3P71C 5JPFA 2NYMC 3IVEA 2Q8UA 3C5WC 4H2IA 2O8AA 3T1IA 5INBA 4JA7A 4MOVA 3H64A 2BQ8X 3H63A 4O43A 4DSYA 2WDCA 3FGAC 4LTYA 3IB7A 2YVTA 4MP0A 1IT6A 2NXFA 3PSNA 3H62B 4FBKA 4HD0A 2QFPA 2DFJA 3K7VC 2IE4C 1FJMA 4V0VA 1T71A 3E7AA 3N5UA 5IOHA 1UTEA 3RQZA 3H67A 4B2OA 1Z2WA 3RL3A 3RL5A 3V4YA 4H2FA 1XZWA 3KBPA 1AUIA 1OIEA 3JYFA 4DHLA 2NPPC 2Z72A 1HP1A 5JPEA 4KBPA 5B8IA 3H61A 2CV9A 3AUZA 4ORAA 5J28A 3DW8C 4ORCA 1OIDA 4XPNA 1W24A 1KBPA 2QFRA 4ZX2A 4LACC 4M0VA 2R17A 5EQVA 4MOYA 1QFCA 2QJCA 3THOB 2Z1AA 4IYPC 3PSOA 5DNYA 3H60A 3AV0A 4YKEA 2XMOA 2GJUA 3ICFA 3QFNA 4UT3B 3K7WC 1II7A 2USHA 4Q7FA 4I5NC 2WDFA 4NZVA 4ZVZA 4J6OA 3C9FA 4H1YP 1S3LA 3QFOA 3THNA 1WARA 3H68A 1OI8A 1SU1A 3HVQA 4IL1A 4KKZA 3H66A 2BDXA 2NYLC
chains in the Genus database with same CATH superfamily
3CK2A 3ZTVA 5JJTA 4H2BA 1HPUA 4V0WA 2BCDA 3IB8A 2ZBMA 3QG5C 1JK7A 4TUGA 2WDEA 1T70A 3QFMA 3DSCA 1S8EA 3E0JA 1NNWA 4OR9A 3IVDA 4O4KA 4V0XA 3E7BA 4FBWA 4I5LC 3H69A 4O5GA 2IAEC 4H1SA 1MF8A 3DSDA 3EGHA 1S70A 1QHWA 2IE3C 2P6BA 4O24A 4JA9A 2Z06A 5HPEA 4WWLA 4TUIA 4G9JA 2HYPA 1S3NA 4ORBA 2JOGA 3TGHA 5C1VA 3QFKA 3EGGA 3FLOA 1S95A 4UT2A 1S3MA 2KKNA 1M63A 4H2GA 1USHA 4FBQA 4UWQA 5GTUA 1HO5A 1TCOA 1V73A 3ZU0A 2HY1A 5F3WA 2WDDA 4FCXA 3GVEA 2A22A 3LL8A 4UT3A 1U32A 4DT2A 2AHDA 2HYOA 1Z2XA 4F0ZA 3H66A 1G5BA 1UF3A 1XM7A 2O8GA 1WAO1 4LU9A 3RL4A 3P71C 5JPFA 2NYMC 3IVEA 2Q8UA 3C5WC 4H2IA 2O8AA 3T1IA 5INBA 4JA7A 4MOVA 3H64A 2BQ8X 3H63A 2ZOAA 4O43A 4DSYA 2WDCA 3FGAC 4LTYA 3IB7A 2YVTA 4MP0A 1IT6A 2NXFA 3PSNA 3D03A 3H62B 4FBKA 4HD0A 2QFPA 2DFJA 3K7VC 2IE4C 1FJMA 4V0VA 1T71A 3E7AA 3N5UA 5IOHA 1UTEA 3RQZA 3H67A 2YEQA 4B2OA 1Z2WA 3RL3A 3RL5A 3V4YA 4H2FA 1XZWA 3KBPA 1AUIA 1OIEA 3JYFA 4DHLA 2NPPC 2ZO9B 2Z72A 1HP1A 5JPEA 4KBPA 5B8IA 3H61A 2CV9A 3AUZA 4ORAA 5J28A 3DW8C 4ORCA 1OIDA 4XPNA 1W24A 1KBPA 2QFRA 4ZX2A 4LACC 4M0VA 2R17A 5EQVA 4MOYA 1QFCA 2QJCA 3THOB 2Z1AA 4IYPC 3PSOA 5DNYA 3H60A 3AV0A 4YKEA 2XMOA 2GJUA 3ICFA 3QFNA 4UT3B 3K7WC 1II7A 2USHA 4Q7FA 4I5NC 2WDFA 4NZVA 4ZVZA 4J6OA 3C9FA 4H1YP 1S3LA 2DXNA 3QFOA 3THNA 1WARA 3H68A 1OI8A 1SU1A 3HVQA 4IL1A 4KKZA 2DXLA 2BDXA 2NYLC
chains in the Genus database with same CATH topology
3CK2A 3ZTVA 5JJTA 4H2BA 1HPUA 4V0WA 2BCDA 3IB8A 2ZBMA 3QG5C 1JK7A 4TUGA 2WDEA 1T70A 3QFMA 3DSCA 1S8EA 3E0JA 1NNWA 4OR9A 3IVDA 4O4KA 4V0XA 3E7BA 4FBWA 4I5LC 3H69A 4O5GA 2IAEC 4H1SA 1MF8A 3DSDA 3EGHA 1S70A 1QHWA 2IE3C 2P6BA 4O24A 4JA9A 2Z06A 5HPEA 4WWLA 4TUIA 4G9JA 2HYPA 1S3NA 4ORBA 2JOGA 3TGHA 5C1VA 3QFKA 3EGGA 3FLOA 1S95A 4UT2A 1S3MA 2KKNA 1M63A 4H2GA 1USHA 4FBQA 4UWQA 5GTUA 1HO5A 1TCOA 1V73A 3ZU0A 2HY1A 5F3WA 2WDDA 4FCXA 3GVEA 2A22A 3LL8A 4UT3A 1U32A 4DT2A 2AHDA 2HYOA 1Z2XA 4F0ZA 3H66A 1G5BA 1UF3A 1XM7A 2O8GA 1WAO1 4LU9A 3RL4A 3P71C 5JPFA 2NYMC 3IVEA 2Q8UA 3C5WC 4H2IA 2O8AA 3T1IA 5INBA 4JA7A 4MOVA 3H64A 2BQ8X 3H63A 2ZOAA 4O43A 4DSYA 2WDCA 3FGAC 4LTYA 3IB7A 2YVTA 4MP0A 1IT6A 2NXFA 3PSNA 3D03A 3H62B 4FBKA 4HD0A 2QFPA 2DFJA 3K7VC 2IE4C 1FJMA 4V0VA 1T71A 3E7AA 3N5UA 5IOHA 1UTEA 3RQZA 3H67A 2YEQA 4B2OA 1Z2WA 3RL3A 3RL5A 3V4YA 4H2FA 1XZWA 3KBPA 1AUIA 1OIEA 3JYFA 4DHLA 2NPPC 2ZO9B 2Z72A 1HP1A 5JPEA 4KBPA 5B8IA 3H61A 2CV9A 3AUZA 4ORAA 5J28A 3DW8C 4ORCA 1OIDA 4XPNA 1W24A 1KBPA 2QFRA 4ZX2A 4LACC 4M0VA 2R17A 5EQVA 4MOYA 1QFCA 2QJCA 3THOB 2Z1AA 4IYPC 3PSOA 5DNYA 3H60A 3AV0A 4YKEA 2XMOA 2GJUA 3ICFA 3QFNA 4UT3B 3K7WC 1II7A 2USHA 4Q7FA 4I5NC 2WDFA 4NZVA 4ZVZA 4J6OA 3C9FA 4H1YP 1S3LA 2DXNA 3QFOA 3THNA 1WARA 3H68A 1OI8A 1SU1A 3HVQA 4IL1A 4KKZA 2DXLA 2BDXA 2NYLC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CK2 A;  3ZTV A;  5JJT A;  4H2B A;  1HPU A;  4V0W A;  2BCD A;  3IB8 A;  2ZBM A;  3QG5 C;  1JK7 A;  4TUG A;  2WDE A;  1T70 A;  3QFM A;  3DSC A;  1S8E A;  4OR9 A;  1NNW A;  3IVD A;  4O4K A;  4V0X A;  3E7B A;  4FBW A;  4I5L C;  3H69 A;  4O5G A;  2IAE C;  4H1S A;  1MF8 A;  3DSD A;  3EGH A;  1S70 A;  1QHW A;  2IE3 C;  2P6B A;  4O24 A;  4JA9 A;  2Z06 A;  5HPE A;  4WWL A;  4TUI A;  4G9J A;  2HYP A;  1S3N A;  4ORB A;  2JOG A;  3TGH A;  5C1V A;  3QFK A;  3EGG A;  1S95 A;  4UT2 A;  1S3M A;  2KKN A;  1M63 A;  4H2G A;  1USH A;  4FBQ A;  4UWQ A;  5GTU A;  1HO5 A;  1TCO A;  1V73 A;  3ZU0 A;  2HY1 A;  5F3W A;  2WDD A;  4FCX A;  3GVE A;  2A22 A;  3LL8 A;  4UT3 A;  1U32 A;  4DT2 A;  2AHD A;  2HYO A;  1Z2X A;  4F0Z A;  1G5B A;  1UF3 A;  1XM7 A;  2O8G A;  1WAO 1;  4LU9 A;  3RL4 A;  3P71 C;  5JPF A;  2NYM C;  3IVE A;  2Q8U A;  3C5W C;  4H2I A;  2O8A A;  3T1I A;  5INB A;  4JA7 A;  4MOV A;  3H64 A;  2BQ8 X;  3H63 A;  4O43 A;  4DSY A;  2WDC A;  3FGA C;  4LTY A;  3IB7 A;  2YVT A;  4MP0 A;  1IT6 A;  2NXF A;  3PSN A;  3H62 B;  4FBK A;  4HD0 A;  2QFP A;  2DFJ A;  3K7V C;  2IE4 C;  1FJM A;  4V0V A;  1T71 A;  3E7A A;  3N5U A;  5IOH A;  1UTE A;  3RQZ A;  3H67 A;  4B2O A;  1Z2W A;  3RL3 A;  3RL5 A;  3V4Y A;  4H2F A;  1XZW A;  3KBP A;  1AUI A;  1OIE A;  3JYF A;  4DHL A;  2NPP C;  2Z72 A;  1HP1 A;  5JPE A;  4KBP A;  5B8I A;  3H61 A;  2CV9 A;  3AUZ A;  4ORA A;  5J28 A;  3DW8 C;  4ORC A;  1OID A;  4XPN A;  1W24 A;  1KBP A;  2QFR A;  4ZX2 A;  4LAC C;  4M0V A;  2R17 A;  5EQV A;  4MOY A;  1QFC A;  2QJC A;  3THO B;  2Z1A A;  4IYP C;  3PSO A;  5DNY A;  3H60 A;  3AV0 A;  4YKE A;  2XMO A;  2GJU A;  3ICF A;  3QFN A;  4UT3 B;  3K7W C;  1II7 A;  2USH A;  4Q7F A;  4I5N C;  2WDF A;  4NZV A;  4ZVZ A;  4J6O A;  3C9F A;  4H1Y P;  1S3L A;  3QFO A;  3THN A;  1WAR A;  3H68 A;  1OI8 A;  1SU1 A;  3HVQ A;  4IL1 A;  4KKZ A;  3H66 A;  2BDX A;  2NYL C; 
#chains in the Genus database with same CATH topology
 3CK2 A;  3ZTV A;  5JJT A;  4H2B A;  1HPU A;  4V0W A;  2BCD A;  3IB8 A;  2ZBM A;  3QG5 C;  1JK7 A;  4TUG A;  2WDE A;  1T70 A;  3QFM A;  3DSC A;  1S8E A;  3E0J A;  1NNW A;  4OR9 A;  3IVD A;  4O4K A;  4V0X A;  3E7B A;  4FBW A;  4I5L C;  3H69 A;  4O5G A;  2IAE C;  4H1S A;  1MF8 A;  3DSD A;  3EGH A;  1S70 A;  1QHW A;  2IE3 C;  2P6B A;  4O24 A;  4JA9 A;  2Z06 A;  5HPE A;  4WWL A;  4TUI A;  4G9J A;  2HYP A;  1S3N A;  4ORB A;  2JOG A;  3TGH A;  5C1V A;  3QFK A;  3EGG A;  3FLO A;  1S95 A;  4UT2 A;  1S3M A;  2KKN A;  1M63 A;  4H2G A;  1USH A;  4FBQ A;  4UWQ A;  5GTU A;  1HO5 A;  1TCO A;  1V73 A;  3ZU0 A;  2HY1 A;  5F3W A;  2WDD A;  4FCX A;  3GVE A;  2A22 A;  3LL8 A;  4UT3 A;  1U32 A;  4DT2 A;  2AHD A;  2HYO A;  1Z2X A;  4F0Z A;  3H66 A;  1G5B A;  1UF3 A;  1XM7 A;  2O8G A;  1WAO 1;  4LU9 A;  3RL4 A;  3P71 C;  5JPF A;  2NYM C;  3IVE A;  2Q8U A;  3C5W C;  4H2I A;  2O8A A;  3T1I A;  5INB A;  4JA7 A;  4MOV A;  3H64 A;  2BQ8 X;  3H63 A;  2ZOA A;  4O43 A;  4DSY A;  2WDC A;  3FGA C;  4LTY A;  3IB7 A;  2YVT A;  4MP0 A;  1IT6 A;  2NXF A;  3PSN A;  3D03 A;  3H62 B;  4FBK A;  4HD0 A;  2QFP A;  2DFJ A;  3K7V C;  2IE4 C;  1FJM A;  4V0V A;  1T71 A;  3E7A A;  3N5U A;  5IOH A;  1UTE A;  3RQZ A;  3H67 A;  2YEQ A;  4B2O A;  1Z2W A;  3RL3 A;  3RL5 A;  3V4Y A;  4H2F A;  1XZW A;  3KBP A;  1AUI A;  1OIE A;  3JYF A;  4DHL A;  2NPP C;  2ZO9 B;  2Z72 A;  1HP1 A;  5JPE A;  4KBP A;  5B8I A;  3H61 A;  2CV9 A;  3AUZ A;  4ORA A;  5J28 A;  3DW8 C;  4ORC A;  1OID A;  4XPN A;  1W24 A;  1KBP A;  2QFR A;  4ZX2 A;  4LAC C;  4M0V A;  2R17 A;  5EQV A;  4MOY A;  1QFC A;  2QJC A;  3THO B;  2Z1A A;  4IYP C;  3PSO A;  5DNY A;  3H60 A;  3AV0 A;  4YKE A;  2XMO A;  2GJU A;  3ICF A;  3QFN A;  4UT3 B;  3K7W C;  1II7 A;  2USH A;  4Q7F A;  4I5N C;  2WDF A;  4NZV A;  4ZVZ A;  4J6O A;  3C9F A;  4H1Y P;  1S3L A;  2DXN A;  3QFO A;  3THN A;  1WAR A;  3H68 A;  1OI8 A;  1SU1 A;  3HVQ A;  4IL1 A;  4KKZ A;  2DXL A;  2BDX A;  2NYL C; 
#chains in the Genus database with same CATH homology
 3CK2 A;  3ZTV A;  5JJT A;  4H2B A;  1HPU A;  4V0W A;  2BCD A;  3IB8 A;  2ZBM A;  3QG5 C;  1JK7 A;  4TUG A;  2WDE A;  1T70 A;  3QFM A;  3DSC A;  1S8E A;  3E0J A;  1NNW A;  4OR9 A;  3IVD A;  4O4K A;  4V0X A;  3E7B A;  4FBW A;  4I5L C;  3H69 A;  4O5G A;  2IAE C;  4H1S A;  1MF8 A;  3DSD A;  3EGH A;  1S70 A;  1QHW A;  2IE3 C;  2P6B A;  4O24 A;  4JA9 A;  2Z06 A;  5HPE A;  4WWL A;  4TUI A;  4G9J A;  2HYP A;  1S3N A;  4ORB A;  2JOG A;  3TGH A;  5C1V A;  3QFK A;  3EGG A;  3FLO A;  1S95 A;  4UT2 A;  1S3M A;  2KKN A;  1M63 A;  4H2G A;  1USH A;  4FBQ A;  4UWQ A;  5GTU A;  1HO5 A;  1TCO A;  1V73 A;  3ZU0 A;  2HY1 A;  5F3W A;  2WDD A;  4FCX A;  3GVE A;  2A22 A;  3LL8 A;  4UT3 A;  1U32 A;  4DT2 A;  2AHD A;  2HYO A;  1Z2X A;  4F0Z A;  3H66 A;  1G5B A;  1UF3 A;  1XM7 A;  2O8G A;  1WAO 1;  4LU9 A;  3RL4 A;  3P71 C;  5JPF A;  2NYM C;  3IVE A;  2Q8U A;  3C5W C;  4H2I A;  2O8A A;  3T1I A;  5INB A;  4JA7 A;  4MOV A;  3H64 A;  2BQ8 X;  3H63 A;  2ZOA A;  4O43 A;  4DSY A;  2WDC A;  3FGA C;  4LTY A;  3IB7 A;  2YVT A;  4MP0 A;  1IT6 A;  2NXF A;  3PSN A;  3D03 A;  3H62 B;  4FBK A;  4HD0 A;  2QFP A;  2DFJ A;  3K7V C;  2IE4 C;  1FJM A;  4V0V A;  1T71 A;  3E7A A;  3N5U A;  5IOH A;  1UTE A;  3RQZ A;  3H67 A;  2YEQ A;  4B2O A;  1Z2W A;  3RL3 A;  3RL5 A;  3V4Y A;  4H2F A;  1XZW A;  3KBP A;  1AUI A;  1OIE A;  3JYF A;  4DHL A;  2NPP C;  2ZO9 B;  2Z72 A;  1HP1 A;  5JPE A;  4KBP A;  5B8I A;  3H61 A;  2CV9 A;  3AUZ A;  4ORA A;  5J28 A;  3DW8 C;  4ORC A;  1OID A;  4XPN A;  1W24 A;  1KBP A;  2QFR A;  4ZX2 A;  4LAC C;  4M0V A;  2R17 A;  5EQV A;  4MOY A;  1QFC A;  2QJC A;  3THO B;  2Z1A A;  4IYP C;  3PSO A;  5DNY A;  3H60 A;  3AV0 A;  4YKE A;  2XMO A;  2GJU A;  3ICF A;  3QFN A;  4UT3 B;  3K7W C;  1II7 A;  2USH A;  4Q7F A;  4I5N C;  2WDF A;  4NZV A;  4ZVZ A;  4J6O A;  3C9F A;  4H1Y P;  1S3L A;  2DXN A;  3QFO A;  3THN A;  1WAR A;  3H68 A;  1OI8 A;  1SU1 A;  3HVQ A;  4IL1 A;  4KKZ A;  2DXL A;  2BDX A;  2NYL C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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