4ORBA

Crystal structure of mouse calcineurin
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
462
structure length
377
Chain Sequence
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSSFEEAKGLDRINERMPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/metal binding protein
source organism Mus musculus
publication title Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
rcsb
molecule keywords Serine/threonine-protein phosphatase 2B catalytic subunit al
total genus 137
structure length 377
sequence length 462
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4orbA00
4LTYA 3QFMA 3QFKA 3H68A 4F0ZA 1HO5A 4ZVZA 4HD0A 4LU9A 1OI8A 4ORBA 4M0VA 1S3LA 4FCXA 4H2IA 5F3WA 3IVDA 1S8EA 1S3NA 1Z2WA 1USHA 3HVQA 3ZTVA 2QFRA 2HY1A 2CV9A 3H67A 1W24A 2NYLC 4WWLA 4XPNA 4MOYA 1S3MA 2A22A 2R17A 1U32A 2IAEC 3H61A 1M63A 1G5BA 3QFOA 3H62B 5HPEA 1TCOA 1II7A 2BQ8X 2ZBMA 3LL8A 4DT2A 3C9FA 1WAO1 3T1IA 3K7VC 1AUIA 1S70A 3TGHA 4YKEA 4OR9A 3GVEA 4J6OA 4JA9A 3EGGA 3RQZA 3PSOA 4FBWA 2QFPA 5DNYA 3AV0A 2JOGA 2DFJA 3IB7A 2AHDA 3N5UA 1XM7A 3RL3A 3DW8C 2O8AA 3KBPA 3RL4A 4ZX2A 2Z72A 5JJTA 2BDXA 3QFNA 5B8IA 1S95A 4TUGA 4H1SA 2WDFA 2YVTA 4H2BA 4O4KA 5IOHA 1JK7A 2XMOA 4O43A 2NPPC 1QHWA 3CK2A 3V4YA 3ZU0A 2GJUA 4B2OA 3H69A 4MP0A 4UT3B 3C5WC 2WDDA 3IB8A 1XZWA 3AUZA 4O24A 4UWQA 3EGHA 2P6BA 4IL1A 4DHLA 2HYOA 4MOVA 3E7BA 4ORAA 2USHA 1T71A 4FBQA 3PSNA 4I5LC 3THNA 1UTEA 1HP1A 2IE4C 2Q8UA 4IYPC 1OIDA 1IT6A 1SU1A 5C1VA 1FJMA 2KKNA 3H66A 3DSDA 4V0VA 1KBPA 5JPFA 4Q7FA 4UT3A 3H60A 3FGAC 1QFCA 3JYFA 3K7WC 4O5GA 2NYMC 1HPUA 4TUIA 4V0XA 3IVEA 4FBKA 1Z2XA 2Z06A 1T70A 1UF3A 4H2GA 3RL5A 5J28A 2NXFA 4KKZA 4I5NC 4ORCA 2BCDA 5INBA 5JPEA 1OIEA 2Z1AA 5GTUA 2IE3C 1V73A 4LACC 4JA7A 3DSCA 1MF8A 2HYPA 5EQVA 2WDEA 4KBPA 1WARA 3QG5C 4V0WA 4H1YP 4UT2A 3ICFA 4H2FA 4NZVA 3THOB 4G9JA 3P71C 3E7AA 3H63A 2QJCA 4DSYA 2WDCA 2O8GA 3H64A 1NNWA
chains in the Genus database with same CATH superfamily
4LTYA 3QFMA 3QFKA 3H68A 4F0ZA 1HO5A 4ZVZA 4HD0A 4LU9A 1OI8A 4ORBA 4M0VA 1S3LA 4FCXA 4H2IA 2DXLA 5F3WA 3IVDA 1S8EA 1S3NA 1Z2WA 1USHA 3HVQA 3ZTVA 2QFRA 2HY1A 2CV9A 3H67A 1W24A 2NYLC 4WWLA 4XPNA 4MOYA 1S3MA 2A22A 2R17A 1U32A 2IAEC 3H61A 1M63A 1G5BA 3QFOA 3H62B 5HPEA 1TCOA 1II7A 2BQ8X 2ZBMA 3LL8A 4DT2A 3C9FA 1WAO1 3T1IA 3K7VC 1AUIA 1S70A 3TGHA 4YKEA 4OR9A 3GVEA 4J6OA 4JA9A 3EGGA 2YEQA 3RQZA 2DXNA 3PSOA 2QFPA 4FBWA 5DNYA 3AV0A 2JOGA 2DFJA 3IB7A 2AHDA 3D03A 3N5UA 1XM7A 3RL3A 3DW8C 2O8AA 3KBPA 3RL4A 4ZX2A 2Z72A 5JJTA 2BDXA 3QFNA 5B8IA 1S95A 4TUGA 4H1SA 2WDFA 2YVTA 4H2BA 4O4KA 5IOHA 1JK7A 2XMOA 4O43A 2NPPC 1QHWA 3CK2A 3V4YA 3ZU0A 2GJUA 4B2OA 3H69A 4MP0A 4UT3B 3C5WC 2WDDA 3IB8A 2ZO9B 1XZWA 3AUZA 4O24A 4UWQA 3EGHA 2P6BA 3E0JA 4IL1A 4DHLA 2HYOA 4MOVA 3E7BA 4ORAA 2USHA 1T71A 4FBQA 3PSNA 4I5LC 3THNA 1UTEA 1HP1A 2IE4C 2Q8UA 4IYPC 1OIDA 1IT6A 1SU1A 5C1VA 1FJMA 2KKNA 3H66A 3DSDA 4V0VA 1KBPA 5JPFA 4Q7FA 4UT3A 3H60A 3FGAC 1QFCA 3JYFA 3K7WC 4O5GA 2NYMC 1HPUA 4TUIA 4V0XA 3IVEA 4FBKA 1Z2XA 2Z06A 1T70A 1UF3A 4H2GA 3RL5A 5J28A 2NXFA 2ZOAA 4I5NC 4KKZA 4ORCA 2BCDA 5INBA 3FLOA 1OIEA 2Z1AA 5GTUA 5JPEA 2IE3C 1V73A 4LACC 4JA7A 3DSCA 1MF8A 2HYPA 5EQVA 2WDEA 4KBPA 1WARA 3QG5C 4V0WA 4H1YP 4UT2A 3ICFA 4H2FA 4NZVA 3THOB 4G9JA 3P71C 3E7AA 3H63A 2QJCA 4DSYA 2WDCA 2O8GA 3H64A 1NNWA
chains in the Genus database with same CATH topology
4LTYA 3QFMA 3QFKA 3H68A 4F0ZA 1HO5A 4ZVZA 4HD0A 4LU9A 1OI8A 4ORBA 4M0VA 1S3LA 4FCXA 4H2IA 2DXLA 5F3WA 3IVDA 1S8EA 1S3NA 1Z2WA 1USHA 3HVQA 3ZTVA 2QFRA 2HY1A 2CV9A 3H67A 1W24A 2NYLC 4WWLA 4XPNA 4MOYA 1S3MA 2A22A 2R17A 1U32A 2IAEC 3H61A 1M63A 1G5BA 3QFOA 3H62B 5HPEA 1TCOA 1II7A 2BQ8X 2ZBMA 3LL8A 4DT2A 3C9FA 1WAO1 3T1IA 3K7VC 1AUIA 1S70A 3TGHA 4YKEA 4OR9A 3GVEA 4J6OA 4JA9A 3EGGA 2YEQA 3RQZA 2DXNA 3PSOA 2QFPA 4FBWA 5DNYA 3AV0A 2JOGA 2DFJA 3IB7A 2AHDA 3D03A 3N5UA 1XM7A 3RL3A 3DW8C 2O8AA 3KBPA 3RL4A 4ZX2A 2Z72A 5JJTA 2BDXA 3QFNA 5B8IA 1S95A 4TUGA 4H1SA 2WDFA 2YVTA 4H2BA 4O4KA 5IOHA 1JK7A 2XMOA 4O43A 2NPPC 1QHWA 3CK2A 3V4YA 3ZU0A 2GJUA 4B2OA 3H69A 4MP0A 4UT3B 3C5WC 2WDDA 3IB8A 2ZO9B 1XZWA 3AUZA 4O24A 4UWQA 3EGHA 2P6BA 3E0JA 4IL1A 4DHLA 2HYOA 4MOVA 3E7BA 4ORAA 2USHA 1T71A 4FBQA 3PSNA 4I5LC 3THNA 1UTEA 1HP1A 2IE4C 2Q8UA 4IYPC 1OIDA 1IT6A 1SU1A 5C1VA 1FJMA 2KKNA 3H66A 3DSDA 4V0VA 1KBPA 5JPFA 4Q7FA 4UT3A 3H60A 3FGAC 1QFCA 3JYFA 3K7WC 4O5GA 2NYMC 1HPUA 4TUIA 4V0XA 3IVEA 4FBKA 1Z2XA 2Z06A 1T70A 1UF3A 4H2GA 3RL5A 5J28A 2NXFA 2ZOAA 4I5NC 4KKZA 4ORCA 2BCDA 5INBA 3FLOA 1OIEA 2Z1AA 5GTUA 5JPEA 2IE3C 1V73A 4LACC 4JA7A 3DSCA 1MF8A 2HYPA 5EQVA 2WDEA 4KBPA 1WARA 3QG5C 4V0WA 4H1YP 4UT2A 3ICFA 4H2FA 4NZVA 3THOB 4G9JA 3P71C 3E7AA 3H63A 2QJCA 4DSYA 2WDCA 2O8GA 3H64A 1NNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LTY A;  3QFM A;  3QFK A;  3H68 A;  4F0Z A;  1HO5 A;  4ZVZ A;  4HD0 A;  4LU9 A;  1OI8 A;  4ORB A;  4M0V A;  1S3L A;  4FCX A;  4H2I A;  5F3W A;  3IVD A;  1S8E A;  1S3N A;  1Z2W A;  1USH A;  3HVQ A;  3ZTV A;  2QFR A;  2HY1 A;  2CV9 A;  3H67 A;  1W24 A;  2NYL C;  4WWL A;  4XPN A;  4MOY A;  1S3M A;  2A22 A;  2R17 A;  1U32 A;  2IAE C;  3H61 A;  1M63 A;  1G5B A;  3QFO A;  3H62 B;  5HPE A;  1TCO A;  1II7 A;  2BQ8 X;  2ZBM A;  3LL8 A;  4DT2 A;  3C9F A;  1WAO 1;  3T1I A;  3K7V C;  1AUI A;  1S70 A;  3TGH A;  4YKE A;  4OR9 A;  3GVE A;  4J6O A;  4JA9 A;  3EGG A;  3RQZ A;  3PSO A;  4FBW A;  2QFP A;  5DNY A;  3AV0 A;  2JOG A;  2DFJ A;  3IB7 A;  2AHD A;  3N5U A;  1XM7 A;  3RL3 A;  3DW8 C;  2O8A A;  3KBP A;  3RL4 A;  4ZX2 A;  2Z72 A;  5JJT A;  2BDX A;  3QFN A;  5B8I A;  1S95 A;  4TUG A;  4H1S A;  2WDF A;  2YVT A;  4H2B A;  4O4K A;  5IOH A;  1JK7 A;  2XMO A;  4O43 A;  2NPP C;  1QHW A;  3CK2 A;  3V4Y A;  3ZU0 A;  2GJU A;  4B2O A;  3H69 A;  4MP0 A;  4UT3 B;  3C5W C;  2WDD A;  3IB8 A;  1XZW A;  3AUZ A;  4O24 A;  4UWQ A;  3EGH A;  2P6B A;  4IL1 A;  4DHL A;  2HYO A;  4MOV A;  3E7B A;  4ORA A;  2USH A;  1T71 A;  4FBQ A;  3PSN A;  4I5L C;  3THN A;  1UTE A;  1HP1 A;  2IE4 C;  2Q8U A;  4IYP C;  1OID A;  1IT6 A;  1SU1 A;  5C1V A;  1FJM A;  2KKN A;  3H66 A;  3DSD A;  4V0V A;  1KBP A;  5JPF A;  4Q7F A;  4UT3 A;  3H60 A;  3FGA C;  1QFC A;  3JYF A;  3K7W C;  4O5G A;  2NYM C;  1HPU A;  4TUI A;  4V0X A;  3IVE A;  4FBK A;  1Z2X A;  2Z06 A;  1T70 A;  1UF3 A;  4H2G A;  3RL5 A;  5J28 A;  2NXF A;  4KKZ A;  4I5N C;  4ORC A;  2BCD A;  5INB A;  5JPE A;  1OIE A;  2Z1A A;  5GTU A;  2IE3 C;  1V73 A;  4LAC C;  4JA7 A;  3DSC A;  1MF8 A;  2HYP A;  5EQV A;  2WDE A;  4KBP A;  1WAR A;  3QG5 C;  4V0W A;  4H1Y P;  4UT2 A;  3ICF A;  4H2F A;  4NZV A;  3THO B;  4G9J A;  3P71 C;  3E7A A;  3H63 A;  2QJC A;  4DSY A;  2WDC A;  2O8G A;  3H64 A;  1NNW A; 
#chains in the Genus database with same CATH topology
 4LTY A;  3QFM A;  3QFK A;  3H68 A;  4F0Z A;  1HO5 A;  4ZVZ A;  4HD0 A;  4LU9 A;  1OI8 A;  4ORB A;  4M0V A;  1S3L A;  4FCX A;  4H2I A;  2DXL A;  5F3W A;  3IVD A;  1S8E A;  1S3N A;  1Z2W A;  1USH A;  3HVQ A;  3ZTV A;  2QFR A;  2HY1 A;  2CV9 A;  3H67 A;  1W24 A;  2NYL C;  4WWL A;  4XPN A;  4MOY A;  1S3M A;  2A22 A;  2R17 A;  1U32 A;  2IAE C;  3H61 A;  1M63 A;  1G5B A;  3QFO A;  3H62 B;  5HPE A;  1TCO A;  1II7 A;  2BQ8 X;  2ZBM A;  3LL8 A;  4DT2 A;  3C9F A;  1WAO 1;  3T1I A;  3K7V C;  1AUI A;  1S70 A;  3TGH A;  4YKE A;  4OR9 A;  3GVE A;  4J6O A;  4JA9 A;  3EGG A;  2YEQ A;  3RQZ A;  2DXN A;  3PSO A;  2QFP A;  4FBW A;  5DNY A;  3AV0 A;  2JOG A;  2DFJ A;  3IB7 A;  2AHD A;  3D03 A;  3N5U A;  1XM7 A;  3RL3 A;  3DW8 C;  2O8A A;  3KBP A;  3RL4 A;  4ZX2 A;  2Z72 A;  5JJT A;  2BDX A;  3QFN A;  5B8I A;  1S95 A;  4TUG A;  4H1S A;  2WDF A;  2YVT A;  4H2B A;  4O4K A;  5IOH A;  1JK7 A;  2XMO A;  4O43 A;  2NPP C;  1QHW A;  3CK2 A;  3V4Y A;  3ZU0 A;  2GJU A;  4B2O A;  3H69 A;  4MP0 A;  4UT3 B;  3C5W C;  2WDD A;  3IB8 A;  2ZO9 B;  1XZW A;  3AUZ A;  4O24 A;  4UWQ A;  3EGH A;  2P6B A;  3E0J A;  4IL1 A;  4DHL A;  2HYO A;  4MOV A;  3E7B A;  4ORA A;  2USH A;  1T71 A;  4FBQ A;  3PSN A;  4I5L C;  3THN A;  1UTE A;  1HP1 A;  2IE4 C;  2Q8U A;  4IYP C;  1OID A;  1IT6 A;  1SU1 A;  5C1V A;  1FJM A;  2KKN A;  3H66 A;  3DSD A;  4V0V A;  1KBP A;  5JPF A;  4Q7F A;  4UT3 A;  3H60 A;  3FGA C;  1QFC A;  3JYF A;  3K7W C;  4O5G A;  2NYM C;  1HPU A;  4TUI A;  4V0X A;  3IVE A;  4FBK A;  1Z2X A;  2Z06 A;  1T70 A;  1UF3 A;  4H2G A;  3RL5 A;  5J28 A;  2NXF A;  2ZOA A;  4I5N C;  4KKZ A;  4ORC A;  2BCD A;  5INB A;  3FLO A;  1OIE A;  2Z1A A;  5GTU A;  5JPE A;  2IE3 C;  1V73 A;  4LAC C;  4JA7 A;  3DSC A;  1MF8 A;  2HYP A;  5EQV A;  2WDE A;  4KBP A;  1WAR A;  3QG5 C;  4V0W A;  4H1Y P;  4UT2 A;  3ICF A;  4H2F A;  4NZV A;  3THO B;  4G9J A;  3P71 C;  3E7A A;  3H63 A;  2QJC A;  4DSY A;  2WDC A;  2O8G A;  3H64 A;  1NNW A; 
#chains in the Genus database with same CATH homology
 4LTY A;  3QFM A;  3QFK A;  3H68 A;  4F0Z A;  1HO5 A;  4ZVZ A;  4HD0 A;  4LU9 A;  1OI8 A;  4ORB A;  4M0V A;  1S3L A;  4FCX A;  4H2I A;  2DXL A;  5F3W A;  3IVD A;  1S8E A;  1S3N A;  1Z2W A;  1USH A;  3HVQ A;  3ZTV A;  2QFR A;  2HY1 A;  2CV9 A;  3H67 A;  1W24 A;  2NYL C;  4WWL A;  4XPN A;  4MOY A;  1S3M A;  2A22 A;  2R17 A;  1U32 A;  2IAE C;  3H61 A;  1M63 A;  1G5B A;  3QFO A;  3H62 B;  5HPE A;  1TCO A;  1II7 A;  2BQ8 X;  2ZBM A;  3LL8 A;  4DT2 A;  3C9F A;  1WAO 1;  3T1I A;  3K7V C;  1AUI A;  1S70 A;  3TGH A;  4YKE A;  4OR9 A;  3GVE A;  4J6O A;  4JA9 A;  3EGG A;  2YEQ A;  3RQZ A;  2DXN A;  3PSO A;  2QFP A;  4FBW A;  5DNY A;  3AV0 A;  2JOG A;  2DFJ A;  3IB7 A;  2AHD A;  3D03 A;  3N5U A;  1XM7 A;  3RL3 A;  3DW8 C;  2O8A A;  3KBP A;  3RL4 A;  4ZX2 A;  2Z72 A;  5JJT A;  2BDX A;  3QFN A;  5B8I A;  1S95 A;  4TUG A;  4H1S A;  2WDF A;  2YVT A;  4H2B A;  4O4K A;  5IOH A;  1JK7 A;  2XMO A;  4O43 A;  2NPP C;  1QHW A;  3CK2 A;  3V4Y A;  3ZU0 A;  2GJU A;  4B2O A;  3H69 A;  4MP0 A;  4UT3 B;  3C5W C;  2WDD A;  3IB8 A;  2ZO9 B;  1XZW A;  3AUZ A;  4O24 A;  4UWQ A;  3EGH A;  2P6B A;  3E0J A;  4IL1 A;  4DHL A;  2HYO A;  4MOV A;  3E7B A;  4ORA A;  2USH A;  1T71 A;  4FBQ A;  3PSN A;  4I5L C;  3THN A;  1UTE A;  1HP1 A;  2IE4 C;  2Q8U A;  4IYP C;  1OID A;  1IT6 A;  1SU1 A;  5C1V A;  1FJM A;  2KKN A;  3H66 A;  3DSD A;  4V0V A;  1KBP A;  5JPF A;  4Q7F A;  4UT3 A;  3H60 A;  3FGA C;  1QFC A;  3JYF A;  3K7W C;  4O5G A;  2NYM C;  1HPU A;  4TUI A;  4V0X A;  3IVE A;  4FBK A;  1Z2X A;  2Z06 A;  1T70 A;  1UF3 A;  4H2G A;  3RL5 A;  5J28 A;  2NXF A;  2ZOA A;  4I5N C;  4KKZ A;  4ORC A;  2BCD A;  5INB A;  3FLO A;  1OIE A;  2Z1A A;  5GTU A;  5JPE A;  2IE3 C;  1V73 A;  4LAC C;  4JA7 A;  3DSC A;  1MF8 A;  2HYP A;  5EQV A;  2WDE A;  4KBP A;  1WAR A;  3QG5 C;  4V0W A;  4H1Y P;  4UT2 A;  3ICF A;  4H2F A;  4NZV A;  3THO B;  4G9J A;  3P71 C;  3E7A A;  3H63 A;  2QJC A;  4DSY A;  2WDC A;  2O8G A;  3H64 A;  1NNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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