4I5LC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
295
structure length
295
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule tags Hydrolase/toxin
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 111
structure length 295
sequence length 295
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5lC00
1NNWA 1S3NA 3RL4A 3H63A 1Z2XA 4ORAA 3DSCA 1II7A 5EQVA 4Q7FA 2BDXA 3H68A 3IVDA 3K7WC 4H1SA 2HYPA 4HD0A 4UWQA 3K7VC 4O24A 2Z06A 4LTYA 4H2GA 2HYOA 3QFOA 4B2OA 2WDFA 3CK2A 4FCXA 4WWLA 3PSNA 4MOVA 3THNA 5F3WA 4DT2A 3EGGA 3N5UA 3LL8A 1V73A 4IL1A 1UTEA 4O5GA 1U32A 1QHWA 5INBA 1S70A 3H67A 3PSOA 4KBPA 3JYFA 2A22A 3AUZA 1M63A 1USHA 1T70A 1OIDA 4LU9A 4V0XA 2NXFA 4KKZA 2JOGA 3THOB 5DNYA 4UT3A 4YKEA 4UT3B 1TCOA 4V0VA 2QJCA 1FJMA 2IAEC 5HPEA 3E7BA 2NPPC 2NYMC 1SU1A 3P71C 4MOYA 1HO5A 1MF8A 4H2IA 3DSDA 3H66A 2BCDA 1OI8A 1S95A 1XM7A 2DFJA 2R17A 2WDEA 1Z2WA 3IB8A 4F0ZA 2KKNA 1W24A 4TUIA 1UF3A 2GJUA 2BQ8X 3DW8C 3RL5A 4V0WA 4FBKA 1JK7A 1WAO1 3IB7A 3H61A 3HVQA 4J6OA 5JPEA 3ZU0A 2HY1A 5JPFA 1QFCA 2P6BA 3H69A 4IYPC 4NZVA 4MP0A 5JJTA 2YVTA 2Z1AA 3EGHA 2QFRA 2CV9A 5IOHA 3TGHA 4H2BA 4ZX2A 3C9FA 2USHA 3QG5C 3T1IA 1KBPA 4JA9A 4ORCA 1HPUA 4G9JA 2IE4C 3QFMA 3RL3A 4DHLA 5J28A 4TUGA 3E7AA 4O43A 3ZTVA 3C5WC 2Q8UA 3KBPA 2XMOA 3RQZA 2AHDA 3QFNA 2NYLC 1AUIA 1S3MA 2O8GA 4H2FA 2O8AA 4DSYA 4O4KA 1S3LA 1G5BA 5C1VA 4FBQA 4UT2A 1OIEA 3FGAC 4I5LC 4OR9A 2IE3C 2WDCA 4H1YP 1T71A 4I5NC 2Z72A 4LACC 4JA7A 4ORBA 3QFKA 3IVEA 2QFPA 3H60A 3H62B 4XPNA 3V4YA 5GTUA 1IT6A 2WDDA 3ICFA 4FBWA 2ZBMA 3AV0A 4M0VA 1XZWA 1S8EA 3GVEA 1HP1A 3H64A 4ZVZA 5B8IA 1WARA
chains in the Genus database with same CATH superfamily
1NNWA 1S3NA 3RL4A 3H63A 1Z2XA 4ORAA 3DSCA 1II7A 5EQVA 4Q7FA 2BDXA 3H68A 3IVDA 3K7WC 4H1SA 2HYPA 4HD0A 4UWQA 3K7VC 4O24A 2DXLA 2Z06A 4H2GA 4LTYA 2HYOA 3QFOA 4B2OA 2WDFA 3CK2A 4FCXA 4WWLA 2YEQA 3PSNA 4MOVA 3THNA 5F3WA 4DT2A 3EGGA 3N5UA 3LL8A 1V73A 4IL1A 1UTEA 4O5GA 1U32A 1QHWA 5INBA 1S70A 3H67A 3PSOA 4KBPA 3JYFA 2A22A 3AUZA 1M63A 1USHA 1T70A 1OIDA 4LU9A 4V0XA 2NXFA 4KKZA 2JOGA 3THOB 5DNYA 4UT3A 4YKEA 4UT3B 1TCOA 4V0VA 2QJCA 1FJMA 2IAEC 5HPEA 2ZO9B 3D03A 3E7BA 2NPPC 2NYMC 1SU1A 3P71C 4MOYA 1HO5A 1MF8A 4H2IA 3DSDA 3H66A 2BCDA 1OI8A 1S95A 1XM7A 2DFJA 2R17A 2WDEA 1Z2WA 3E0JA 3IB8A 4F0ZA 2KKNA 1W24A 4TUIA 1UF3A 2GJUA 2BQ8X 3DW8C 3RL5A 4V0WA 4FBKA 1JK7A 1WAO1 3IB7A 3H61A 3HVQA 4J6OA 5JPEA 3ZU0A 2HY1A 5JPFA 2DXNA 1QFCA 2P6BA 3H69A 4IYPC 4NZVA 4MP0A 5JJTA 2YVTA 2Z1AA 3EGHA 2QFRA 2CV9A 5IOHA 3TGHA 4H2BA 4ZX2A 3C9FA 2USHA 3QG5C 3T1IA 1KBPA 4JA9A 4ORCA 1HPUA 4G9JA 2IE4C 3QFMA 3RL3A 4DHLA 5J28A 4TUGA 3E7AA 4O43A 2ZOAA 3ZTVA 3C5WC 2Q8UA 3KBPA 2XMOA 3RQZA 2AHDA 3QFNA 2NYLC 1AUIA 1S3MA 2O8GA 4H2FA 2O8AA 4DSYA 4O4KA 1S3LA 1G5BA 5C1VA 4FBQA 4UT2A 1OIEA 3FGAC 4I5LC 4OR9A 2IE3C 2WDCA 3FLOA 4H1YP 1T71A 4I5NC 2Z72A 4LACC 4JA7A 4ORBA 3QFKA 3IVEA 2QFPA 3H60A 3H62B 4XPNA 3V4YA 5GTUA 1IT6A 2WDDA 3ICFA 4FBWA 2ZBMA 3AV0A 4M0VA 1XZWA 1S8EA 3GVEA 1HP1A 3H64A 4ZVZA 5B8IA 1WARA
chains in the Genus database with same CATH topology
1NNWA 1S3NA 3RL4A 3H63A 1Z2XA 4ORAA 3DSCA 1II7A 5EQVA 4Q7FA 2BDXA 3H68A 3IVDA 3K7WC 4H1SA 2HYPA 4HD0A 4UWQA 3K7VC 4O24A 2DXLA 2Z06A 4H2GA 4LTYA 2HYOA 3QFOA 4B2OA 2WDFA 3CK2A 4FCXA 4WWLA 2YEQA 3PSNA 4MOVA 3THNA 5F3WA 4DT2A 3EGGA 3N5UA 3LL8A 1V73A 4IL1A 1UTEA 4O5GA 1U32A 1QHWA 5INBA 1S70A 3H67A 3PSOA 4KBPA 3JYFA 2A22A 3AUZA 1M63A 1USHA 1T70A 1OIDA 4LU9A 4V0XA 2NXFA 4KKZA 2JOGA 3THOB 5DNYA 4UT3A 4YKEA 4UT3B 1TCOA 4V0VA 2QJCA 1FJMA 2IAEC 5HPEA 2ZO9B 3D03A 3E7BA 2NPPC 2NYMC 1SU1A 3P71C 4MOYA 1HO5A 1MF8A 4H2IA 3DSDA 3H66A 2BCDA 1OI8A 1S95A 1XM7A 2DFJA 2R17A 2WDEA 1Z2WA 3E0JA 3IB8A 4F0ZA 2KKNA 1W24A 4TUIA 1UF3A 2GJUA 2BQ8X 3DW8C 3RL5A 4V0WA 4FBKA 1JK7A 1WAO1 3IB7A 3H61A 3HVQA 4J6OA 5JPEA 3ZU0A 2HY1A 5JPFA 2DXNA 1QFCA 2P6BA 3H69A 4IYPC 4NZVA 4MP0A 5JJTA 2YVTA 2Z1AA 3EGHA 2QFRA 2CV9A 5IOHA 3TGHA 4H2BA 4ZX2A 3C9FA 2USHA 3QG5C 3T1IA 1KBPA 4JA9A 4ORCA 1HPUA 4G9JA 2IE4C 3QFMA 3RL3A 4DHLA 5J28A 4TUGA 3E7AA 4O43A 2ZOAA 3ZTVA 3C5WC 2Q8UA 3KBPA 2XMOA 3RQZA 2AHDA 3QFNA 2NYLC 1AUIA 1S3MA 2O8GA 4H2FA 2O8AA 4DSYA 4O4KA 1S3LA 1G5BA 5C1VA 4FBQA 4UT2A 1OIEA 3FGAC 4I5LC 4OR9A 2IE3C 2WDCA 3FLOA 4H1YP 1T71A 4I5NC 2Z72A 4LACC 4JA7A 4ORBA 3QFKA 3IVEA 2QFPA 3H60A 3H62B 4XPNA 3V4YA 5GTUA 1IT6A 2WDDA 3ICFA 4FBWA 2ZBMA 3AV0A 4M0VA 1XZWA 1S8EA 3GVEA 1HP1A 3H64A 4ZVZA 5B8IA 1WARA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NNW A;  1S3N A;  3RL4 A;  3H63 A;  1Z2X A;  4ORA A;  3DSC A;  1II7 A;  5EQV A;  4Q7F A;  2BDX A;  3H68 A;  3IVD A;  3K7W C;  4H1S A;  2HYP A;  4HD0 A;  4UWQ A;  3K7V C;  4O24 A;  2Z06 A;  4LTY A;  4H2G A;  2HYO A;  3QFO A;  4B2O A;  2WDF A;  3CK2 A;  4FCX A;  4WWL A;  3PSN A;  4MOV A;  3THN A;  5F3W A;  4DT2 A;  3EGG A;  3N5U A;  3LL8 A;  1V73 A;  4IL1 A;  1UTE A;  4O5G A;  1U32 A;  1QHW A;  5INB A;  1S70 A;  3H67 A;  3PSO A;  4KBP A;  3JYF A;  2A22 A;  3AUZ A;  1M63 A;  1USH A;  1T70 A;  1OID A;  4LU9 A;  4V0X A;  2NXF A;  4KKZ A;  2JOG A;  3THO B;  5DNY A;  4UT3 A;  4YKE A;  4UT3 B;  1TCO A;  4V0V A;  2QJC A;  1FJM A;  2IAE C;  5HPE A;  3E7B A;  2NPP C;  2NYM C;  1SU1 A;  3P71 C;  4MOY A;  1HO5 A;  1MF8 A;  4H2I A;  3DSD A;  3H66 A;  2BCD A;  1OI8 A;  1S95 A;  1XM7 A;  2DFJ A;  2R17 A;  2WDE A;  1Z2W A;  3IB8 A;  4F0Z A;  2KKN A;  1W24 A;  4TUI A;  1UF3 A;  2GJU A;  2BQ8 X;  3DW8 C;  3RL5 A;  4V0W A;  4FBK A;  1JK7 A;  1WAO 1;  3IB7 A;  3H61 A;  3HVQ A;  4J6O A;  5JPE A;  3ZU0 A;  2HY1 A;  5JPF A;  1QFC A;  2P6B A;  3H69 A;  4IYP C;  4NZV A;  4MP0 A;  5JJT A;  2YVT A;  2Z1A A;  3EGH A;  2QFR A;  2CV9 A;  5IOH A;  3TGH A;  4H2B A;  4ZX2 A;  3C9F A;  2USH A;  3QG5 C;  3T1I A;  1KBP A;  4JA9 A;  4ORC A;  1HPU A;  4G9J A;  2IE4 C;  3QFM A;  3RL3 A;  4DHL A;  5J28 A;  4TUG A;  3E7A A;  4O43 A;  3ZTV A;  3C5W C;  2Q8U A;  3KBP A;  2XMO A;  3RQZ A;  2AHD A;  3QFN A;  2NYL C;  1AUI A;  1S3M A;  2O8G A;  4H2F A;  2O8A A;  4DSY A;  4O4K A;  1S3L A;  1G5B A;  5C1V A;  4FBQ A;  4UT2 A;  1OIE A;  3FGA C;  4I5L C;  4OR9 A;  2IE3 C;  2WDC A;  4H1Y P;  1T71 A;  4I5N C;  2Z72 A;  4LAC C;  4JA7 A;  4ORB A;  3QFK A;  3IVE A;  2QFP A;  3H60 A;  3H62 B;  4XPN A;  3V4Y A;  5GTU A;  1IT6 A;  2WDD A;  3ICF A;  4FBW A;  2ZBM A;  3AV0 A;  4M0V A;  1XZW A;  1S8E A;  3GVE A;  1HP1 A;  3H64 A;  4ZVZ A;  5B8I A;  1WAR A; 
#chains in the Genus database with same CATH topology
 1NNW A;  1S3N A;  3RL4 A;  3H63 A;  1Z2X A;  4ORA A;  3DSC A;  1II7 A;  5EQV A;  4Q7F A;  2BDX A;  3H68 A;  3IVD A;  3K7W C;  4H1S A;  2HYP A;  4HD0 A;  4UWQ A;  3K7V C;  4O24 A;  2DXL A;  2Z06 A;  4H2G A;  4LTY A;  2HYO A;  3QFO A;  4B2O A;  2WDF A;  3CK2 A;  4FCX A;  4WWL A;  2YEQ A;  3PSN A;  4MOV A;  3THN A;  5F3W A;  4DT2 A;  3EGG A;  3N5U A;  3LL8 A;  1V73 A;  4IL1 A;  1UTE A;  4O5G A;  1U32 A;  1QHW A;  5INB A;  1S70 A;  3H67 A;  3PSO A;  4KBP A;  3JYF A;  2A22 A;  3AUZ A;  1M63 A;  1USH A;  1T70 A;  1OID A;  4LU9 A;  4V0X A;  2NXF A;  4KKZ A;  2JOG A;  3THO B;  5DNY A;  4UT3 A;  4YKE A;  4UT3 B;  1TCO A;  4V0V A;  2QJC A;  1FJM A;  2IAE C;  5HPE A;  2ZO9 B;  3D03 A;  3E7B A;  2NPP C;  2NYM C;  1SU1 A;  3P71 C;  4MOY A;  1HO5 A;  1MF8 A;  4H2I A;  3DSD A;  3H66 A;  2BCD A;  1OI8 A;  1S95 A;  1XM7 A;  2DFJ A;  2R17 A;  2WDE A;  1Z2W A;  3E0J A;  3IB8 A;  4F0Z A;  2KKN A;  1W24 A;  4TUI A;  1UF3 A;  2GJU A;  2BQ8 X;  3DW8 C;  3RL5 A;  4V0W A;  4FBK A;  1JK7 A;  1WAO 1;  3IB7 A;  3H61 A;  3HVQ A;  4J6O A;  5JPE A;  3ZU0 A;  2HY1 A;  5JPF A;  2DXN A;  1QFC A;  2P6B A;  3H69 A;  4IYP C;  4NZV A;  4MP0 A;  5JJT A;  2YVT A;  2Z1A A;  3EGH A;  2QFR A;  2CV9 A;  5IOH A;  3TGH A;  4H2B A;  4ZX2 A;  3C9F A;  2USH A;  3QG5 C;  3T1I A;  1KBP A;  4JA9 A;  4ORC A;  1HPU A;  4G9J A;  2IE4 C;  3QFM A;  3RL3 A;  4DHL A;  5J28 A;  4TUG A;  3E7A A;  4O43 A;  2ZOA A;  3ZTV A;  3C5W C;  2Q8U A;  3KBP A;  2XMO A;  3RQZ A;  2AHD A;  3QFN A;  2NYL C;  1AUI A;  1S3M A;  2O8G A;  4H2F A;  2O8A A;  4DSY A;  4O4K A;  1S3L A;  1G5B A;  5C1V A;  4FBQ A;  4UT2 A;  1OIE A;  3FGA C;  4I5L C;  4OR9 A;  2IE3 C;  2WDC A;  3FLO A;  4H1Y P;  1T71 A;  4I5N C;  2Z72 A;  4LAC C;  4JA7 A;  4ORB A;  3QFK A;  3IVE A;  2QFP A;  3H60 A;  3H62 B;  4XPN A;  3V4Y A;  5GTU A;  1IT6 A;  2WDD A;  3ICF A;  4FBW A;  2ZBM A;  3AV0 A;  4M0V A;  1XZW A;  1S8E A;  3GVE A;  1HP1 A;  3H64 A;  4ZVZ A;  5B8I A;  1WAR A; 
#chains in the Genus database with same CATH homology
 1NNW A;  1S3N A;  3RL4 A;  3H63 A;  1Z2X A;  4ORA A;  3DSC A;  1II7 A;  5EQV A;  4Q7F A;  2BDX A;  3H68 A;  3IVD A;  3K7W C;  4H1S A;  2HYP A;  4HD0 A;  4UWQ A;  3K7V C;  4O24 A;  2DXL A;  2Z06 A;  4H2G A;  4LTY A;  2HYO A;  3QFO A;  4B2O A;  2WDF A;  3CK2 A;  4FCX A;  4WWL A;  2YEQ A;  3PSN A;  4MOV A;  3THN A;  5F3W A;  4DT2 A;  3EGG A;  3N5U A;  3LL8 A;  1V73 A;  4IL1 A;  1UTE A;  4O5G A;  1U32 A;  1QHW A;  5INB A;  1S70 A;  3H67 A;  3PSO A;  4KBP A;  3JYF A;  2A22 A;  3AUZ A;  1M63 A;  1USH A;  1T70 A;  1OID A;  4LU9 A;  4V0X A;  2NXF A;  4KKZ A;  2JOG A;  3THO B;  5DNY A;  4UT3 A;  4YKE A;  4UT3 B;  1TCO A;  4V0V A;  2QJC A;  1FJM A;  2IAE C;  5HPE A;  2ZO9 B;  3D03 A;  3E7B A;  2NPP C;  2NYM C;  1SU1 A;  3P71 C;  4MOY A;  1HO5 A;  1MF8 A;  4H2I A;  3DSD A;  3H66 A;  2BCD A;  1OI8 A;  1S95 A;  1XM7 A;  2DFJ A;  2R17 A;  2WDE A;  1Z2W A;  3E0J A;  3IB8 A;  4F0Z A;  2KKN A;  1W24 A;  4TUI A;  1UF3 A;  2GJU A;  2BQ8 X;  3DW8 C;  3RL5 A;  4V0W A;  4FBK A;  1JK7 A;  1WAO 1;  3IB7 A;  3H61 A;  3HVQ A;  4J6O A;  5JPE A;  3ZU0 A;  2HY1 A;  5JPF A;  2DXN A;  1QFC A;  2P6B A;  3H69 A;  4IYP C;  4NZV A;  4MP0 A;  5JJT A;  2YVT A;  2Z1A A;  3EGH A;  2QFR A;  2CV9 A;  5IOH A;  3TGH A;  4H2B A;  4ZX2 A;  3C9F A;  2USH A;  3QG5 C;  3T1I A;  1KBP A;  4JA9 A;  4ORC A;  1HPU A;  4G9J A;  2IE4 C;  3QFM A;  3RL3 A;  4DHL A;  5J28 A;  4TUG A;  3E7A A;  4O43 A;  2ZOA A;  3ZTV A;  3C5W C;  2Q8U A;  3KBP A;  2XMO A;  3RQZ A;  2AHD A;  3QFN A;  2NYL C;  1AUI A;  1S3M A;  2O8G A;  4H2F A;  2O8A A;  4DSY A;  4O4K A;  1S3L A;  1G5B A;  5C1V A;  4FBQ A;  4UT2 A;  1OIE A;  3FGA C;  4I5L C;  4OR9 A;  2IE3 C;  2WDC A;  3FLO A;  4H1Y P;  1T71 A;  4I5N C;  2Z72 A;  4LAC C;  4JA7 A;  4ORB A;  3QFK A;  3IVE A;  2QFP A;  3H60 A;  3H62 B;  4XPN A;  3V4Y A;  5GTU A;  1IT6 A;  2WDD A;  3ICF A;  4FBW A;  2ZBM A;  3AV0 A;  4M0V A;  1XZW A;  1S8E A;  3GVE A;  1HP1 A;  3H64 A;  4ZVZ A;  5B8I A;  1WAR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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