4I5NC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule tags Hydrolase/toxin
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 104
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5nC00
4MOYA 3E7BA 4YKEA 2JOGA 3P71C 2YVTA 4JA7A 1S95A 2GJUA 1S70A 2WDDA 3DW8C 1V73A 3ZU0A 5DNYA 5B8IA 3N5UA 4DT2A 1IT6A 4V0XA 1M63A 2O8GA 1OIDA 1S8EA 1HO5A 3K7VC 1HP1A 4V0WA 3IB8A 1G5BA 5IOHA 4M0VA 1OIEA 4O43A 4ORCA 2IE3C 2NXFA 2ZBMA 5EQVA 2QFPA 3PSNA 3T1IA 3DSCA 3IVEA 1T70A 2HY1A 1SU1A 4TUIA 4H1YP 1HPUA 1II7A 4MP0A 3H60A 5JPFA 3K7WC 4FBKA 1NNWA 2WDFA 2NYMC 2Q8UA 3EGHA 2IAEC 3H63A 1AUIA 4IYPC 3QG5C 4DHLA 4UT3A 3KBPA 1QHWA 3QFMA 3QFNA 1T71A 1XZWA 2WDEA 2XMOA 2KKNA 3DSDA 3ICFA 4OR9A 3RQZA 2DFJA 5F3WA 1TCOA 3C9FA 3FGAC 4DSYA 4B2OA 4HD0A 4I5NC 2R17A 2HYOA 3JYFA 2BCDA 1Z2WA 1KBPA 1OI8A 4H2BA 1UTEA 4KKZA 2IE4C 2Z1AA 3H67A 4J6OA 2CV9A 4UT3B 4WWLA 4FBWA 1QFCA 4Q7FA 3RL3A 5JPEA 2HYPA 4UT2A 2NPPC 3V4YA 1UF3A 2BDXA 5C1VA 1WAO1 2AHDA 2P6BA 3IB7A 3QFKA 4O24A 5JJTA 3EGGA 4UWQA 4IL1A 1XM7A 1Z2XA 2QFRA 4ZVZA 1USHA 2NYLC 3TGHA 1S3LA 3H64A 4LTYA 3H61A 3AUZA 2A22A 4F0ZA 4H2GA 3PSOA 3QFOA 4O4KA 3AV0A 4JA9A 2WDCA 2Z06A 4TUGA 1U32A 2O8AA 4XPNA 3CK2A 3GVEA 4O5GA 3H66A 4FCXA 1FJMA 5GTUA 3THNA 4MOVA 4ZX2A 3HVQA 4H2IA 5HPEA 4H2FA 1JK7A 3E7AA 4I5LC 4V0VA 1S3MA 3H62B 2USHA 5J28A 4LACC 3ZTVA 2Z72A 4H1SA 4NZVA 4ORBA 3RL5A 4G9JA 4LU9A 3C5WC 4ORAA 2BQ8X 4FBQA 2QJCA 1W24A 1WARA 3H68A 3LL8A 1MF8A 3IVDA 3THOB 4KBPA 1S3NA 3H69A 5INBA 3RL4A
chains in the Genus database with same CATH superfamily
4MOYA 3E7BA 4YKEA 2JOGA 3P71C 2YVTA 4JA7A 1S95A 2GJUA 1S70A 2WDDA 3DW8C 1V73A 3ZU0A 5DNYA 5B8IA 3N5UA 4DT2A 1IT6A 4V0XA 1M63A 2O8GA 1OIDA 1S8EA 1HO5A 3K7VC 1HP1A 4V0WA 3IB8A 1G5BA 5IOHA 4M0VA 1OIEA 3FLOA 4O43A 4ORCA 2IE3C 2NXFA 2ZBMA 5EQVA 2QFPA 3PSNA 3T1IA 3DSCA 3E0JA 1T70A 3IVEA 2ZO9B 2HY1A 1SU1A 4TUIA 4H1YP 1HPUA 1II7A 4MP0A 3H60A 5JPFA 3K7WC 4FBKA 1NNWA 2WDFA 2NYMC 2Q8UA 3EGHA 2IAEC 3H63A 1AUIA 4IYPC 3QG5C 4DHLA 4UT3A 3KBPA 1QHWA 3QFMA 3QFNA 1T71A 1XZWA 2WDEA 2XMOA 2KKNA 3DSDA 3ICFA 4OR9A 3RQZA 2DFJA 2YEQA 5F3WA 1TCOA 3C9FA 3FGAC 4DSYA 4B2OA 4HD0A 4I5NC 2R17A 2HYOA 3JYFA 2BCDA 1Z2WA 1KBPA 1OI8A 4H2BA 1UTEA 4KKZA 2IE4C 2Z1AA 3H67A 4J6OA 2CV9A 4UT3B 4WWLA 4FBWA 1QFCA 4Q7FA 3RL3A 2ZOAA 2HYPA 4UT2A 2NPPC 5JPEA 3V4YA 1UF3A 2BDXA 5C1VA 1WAO1 2AHDA 2P6BA 3IB7A 3QFKA 4O24A 5JJTA 3EGGA 4UWQA 4IL1A 1XM7A 1Z2XA 2QFRA 4ZVZA 1USHA 2NYLC 3TGHA 1S3LA 3H64A 4LTYA 3H61A 3AUZA 2A22A 4F0ZA 4H2GA 3PSOA 3QFOA 4O4KA 3AV0A 4JA9A 2DXLA 2WDCA 2Z06A 4TUGA 1U32A 2O8AA 4XPNA 3CK2A 3GVEA 4O5GA 3H66A 4FCXA 1FJMA 5GTUA 3THNA 4MOVA 4ZX2A 3HVQA 4H2IA 5HPEA 4H2FA 1JK7A 3E7AA 3D03A 4I5LC 4V0VA 1S3MA 3H62B 2USHA 2DXNA 5J28A 4LACC 3ZTVA 2Z72A 4H1SA 4NZVA 4ORBA 3RL5A 4G9JA 4LU9A 3C5WC 4ORAA 2BQ8X 4FBQA 2QJCA 1W24A 1WARA 3H68A 3LL8A 1MF8A 3IVDA 3THOB 4KBPA 1S3NA 3H69A 5INBA 3RL4A
chains in the Genus database with same CATH topology
4MOYA 3E7BA 4YKEA 2JOGA 3P71C 2YVTA 4JA7A 1S95A 2GJUA 1S70A 2WDDA 3DW8C 1V73A 3ZU0A 5DNYA 5B8IA 3N5UA 4DT2A 1IT6A 4V0XA 1M63A 2O8GA 1OIDA 1S8EA 1HO5A 3K7VC 1HP1A 4V0WA 3IB8A 1G5BA 5IOHA 4M0VA 1OIEA 3FLOA 4O43A 4ORCA 2IE3C 2NXFA 2ZBMA 5EQVA 2QFPA 3PSNA 3T1IA 3DSCA 3E0JA 1T70A 3IVEA 2ZO9B 2HY1A 1SU1A 4TUIA 4H1YP 1HPUA 1II7A 4MP0A 3H60A 5JPFA 3K7WC 4FBKA 1NNWA 2WDFA 2NYMC 2Q8UA 3EGHA 2IAEC 3H63A 1AUIA 4IYPC 3QG5C 4DHLA 4UT3A 3KBPA 1QHWA 3QFMA 3QFNA 1T71A 1XZWA 2WDEA 2XMOA 2KKNA 3DSDA 3ICFA 4OR9A 3RQZA 2DFJA 2YEQA 5F3WA 1TCOA 3C9FA 3FGAC 4DSYA 4B2OA 4HD0A 4I5NC 2R17A 2HYOA 3JYFA 2BCDA 1Z2WA 1KBPA 1OI8A 4H2BA 1UTEA 4KKZA 2IE4C 2Z1AA 3H67A 4J6OA 2CV9A 4UT3B 4WWLA 4FBWA 1QFCA 4Q7FA 3RL3A 2ZOAA 2HYPA 4UT2A 2NPPC 5JPEA 3V4YA 1UF3A 2BDXA 5C1VA 1WAO1 2AHDA 2P6BA 3IB7A 3QFKA 4O24A 5JJTA 3EGGA 4UWQA 4IL1A 1XM7A 1Z2XA 2QFRA 4ZVZA 1USHA 2NYLC 3TGHA 1S3LA 3H64A 4LTYA 3H61A 3AUZA 2A22A 4F0ZA 4H2GA 3PSOA 3QFOA 4O4KA 3AV0A 4JA9A 2DXLA 2WDCA 2Z06A 4TUGA 1U32A 2O8AA 4XPNA 3CK2A 3GVEA 4O5GA 3H66A 4FCXA 1FJMA 5GTUA 3THNA 4MOVA 4ZX2A 3HVQA 4H2IA 5HPEA 4H2FA 1JK7A 3E7AA 3D03A 4I5LC 4V0VA 1S3MA 3H62B 2USHA 2DXNA 5J28A 4LACC 3ZTVA 2Z72A 4H1SA 4NZVA 4ORBA 3RL5A 4G9JA 4LU9A 3C5WC 4ORAA 2BQ8X 4FBQA 2QJCA 1W24A 1WARA 3H68A 3LL8A 1MF8A 3IVDA 3THOB 4KBPA 1S3NA 3H69A 5INBA 3RL4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MOY A;  3E7B A;  4YKE A;  2JOG A;  3P71 C;  2YVT A;  4JA7 A;  1S95 A;  2GJU A;  1S70 A;  2WDD A;  3DW8 C;  1V73 A;  3ZU0 A;  5DNY A;  5B8I A;  3N5U A;  4DT2 A;  1IT6 A;  4V0X A;  1M63 A;  2O8G A;  1OID A;  1S8E A;  1HO5 A;  3K7V C;  1HP1 A;  4V0W A;  3IB8 A;  1G5B A;  5IOH A;  4M0V A;  1OIE A;  4O43 A;  4ORC A;  2IE3 C;  2NXF A;  2ZBM A;  5EQV A;  2QFP A;  3PSN A;  3T1I A;  3DSC A;  3IVE A;  1T70 A;  2HY1 A;  1SU1 A;  4TUI A;  4H1Y P;  1HPU A;  1II7 A;  4MP0 A;  3H60 A;  5JPF A;  3K7W C;  4FBK A;  1NNW A;  2WDF A;  2NYM C;  2Q8U A;  3EGH A;  2IAE C;  3H63 A;  1AUI A;  4IYP C;  3QG5 C;  4DHL A;  4UT3 A;  3KBP A;  1QHW A;  3QFM A;  3QFN A;  1T71 A;  1XZW A;  2WDE A;  2XMO A;  2KKN A;  3DSD A;  3ICF A;  4OR9 A;  3RQZ A;  2DFJ A;  5F3W A;  1TCO A;  3C9F A;  3FGA C;  4DSY A;  4B2O A;  4HD0 A;  4I5N C;  2R17 A;  2HYO A;  3JYF A;  2BCD A;  1Z2W A;  1KBP A;  1OI8 A;  4H2B A;  1UTE A;  4KKZ A;  2IE4 C;  2Z1A A;  3H67 A;  4J6O A;  2CV9 A;  4UT3 B;  4WWL A;  4FBW A;  1QFC A;  4Q7F A;  3RL3 A;  5JPE A;  2HYP A;  4UT2 A;  2NPP C;  3V4Y A;  1UF3 A;  2BDX A;  5C1V A;  1WAO 1;  2AHD A;  2P6B A;  3IB7 A;  3QFK A;  4O24 A;  5JJT A;  3EGG A;  4UWQ A;  4IL1 A;  1XM7 A;  1Z2X A;  2QFR A;  4ZVZ A;  1USH A;  2NYL C;  3TGH A;  1S3L A;  3H64 A;  4LTY A;  3H61 A;  3AUZ A;  2A22 A;  4F0Z A;  4H2G A;  3PSO A;  3QFO A;  4O4K A;  3AV0 A;  4JA9 A;  2WDC A;  2Z06 A;  4TUG A;  1U32 A;  2O8A A;  4XPN A;  3CK2 A;  3GVE A;  4O5G A;  3H66 A;  4FCX A;  1FJM A;  5GTU A;  3THN A;  4MOV A;  4ZX2 A;  3HVQ A;  4H2I A;  5HPE A;  4H2F A;  1JK7 A;  3E7A A;  4I5L C;  4V0V A;  1S3M A;  3H62 B;  2USH A;  5J28 A;  4LAC C;  3ZTV A;  2Z72 A;  4H1S A;  4NZV A;  4ORB A;  3RL5 A;  4G9J A;  4LU9 A;  3C5W C;  4ORA A;  2BQ8 X;  4FBQ A;  2QJC A;  1W24 A;  1WAR A;  3H68 A;  3LL8 A;  1MF8 A;  3IVD A;  3THO B;  4KBP A;  1S3N A;  3H69 A;  5INB A;  3RL4 A; 
#chains in the Genus database with same CATH topology
 4MOY A;  3E7B A;  4YKE A;  2JOG A;  3P71 C;  2YVT A;  4JA7 A;  1S95 A;  2GJU A;  1S70 A;  2WDD A;  3DW8 C;  1V73 A;  3ZU0 A;  5DNY A;  5B8I A;  3N5U A;  4DT2 A;  1IT6 A;  4V0X A;  1M63 A;  2O8G A;  1OID A;  1S8E A;  1HO5 A;  3K7V C;  1HP1 A;  4V0W A;  3IB8 A;  1G5B A;  5IOH A;  4M0V A;  1OIE A;  3FLO A;  4O43 A;  4ORC A;  2IE3 C;  2NXF A;  2ZBM A;  5EQV A;  2QFP A;  3PSN A;  3T1I A;  3DSC A;  3E0J A;  1T70 A;  3IVE A;  2ZO9 B;  2HY1 A;  1SU1 A;  4TUI A;  4H1Y P;  1HPU A;  1II7 A;  4MP0 A;  3H60 A;  5JPF A;  3K7W C;  4FBK A;  1NNW A;  2WDF A;  2NYM C;  2Q8U A;  3EGH A;  2IAE C;  3H63 A;  1AUI A;  4IYP C;  3QG5 C;  4DHL A;  4UT3 A;  3KBP A;  1QHW A;  3QFM A;  3QFN A;  1T71 A;  1XZW A;  2WDE A;  2XMO A;  2KKN A;  3DSD A;  3ICF A;  4OR9 A;  3RQZ A;  2DFJ A;  2YEQ A;  5F3W A;  1TCO A;  3C9F A;  3FGA C;  4DSY A;  4B2O A;  4HD0 A;  4I5N C;  2R17 A;  2HYO A;  3JYF A;  2BCD A;  1Z2W A;  1KBP A;  1OI8 A;  4H2B A;  1UTE A;  4KKZ A;  2IE4 C;  2Z1A A;  3H67 A;  4J6O A;  2CV9 A;  4UT3 B;  4WWL A;  4FBW A;  1QFC A;  4Q7F A;  3RL3 A;  2ZOA A;  2HYP A;  4UT2 A;  2NPP C;  5JPE A;  3V4Y A;  1UF3 A;  2BDX A;  5C1V A;  1WAO 1;  2AHD A;  2P6B A;  3IB7 A;  3QFK A;  4O24 A;  5JJT A;  3EGG A;  4UWQ A;  4IL1 A;  1XM7 A;  1Z2X A;  2QFR A;  4ZVZ A;  1USH A;  2NYL C;  3TGH A;  1S3L A;  3H64 A;  4LTY A;  3H61 A;  3AUZ A;  2A22 A;  4F0Z A;  4H2G A;  3PSO A;  3QFO A;  4O4K A;  3AV0 A;  4JA9 A;  2DXL A;  2WDC A;  2Z06 A;  4TUG A;  1U32 A;  2O8A A;  4XPN A;  3CK2 A;  3GVE A;  4O5G A;  3H66 A;  4FCX A;  1FJM A;  5GTU A;  3THN A;  4MOV A;  4ZX2 A;  3HVQ A;  4H2I A;  5HPE A;  4H2F A;  1JK7 A;  3E7A A;  3D03 A;  4I5L C;  4V0V A;  1S3M A;  3H62 B;  2USH A;  2DXN A;  5J28 A;  4LAC C;  3ZTV A;  2Z72 A;  4H1S A;  4NZV A;  4ORB A;  3RL5 A;  4G9J A;  4LU9 A;  3C5W C;  4ORA A;  2BQ8 X;  4FBQ A;  2QJC A;  1W24 A;  1WAR A;  3H68 A;  3LL8 A;  1MF8 A;  3IVD A;  3THO B;  4KBP A;  1S3N A;  3H69 A;  5INB A;  3RL4 A; 
#chains in the Genus database with same CATH homology
 4MOY A;  3E7B A;  4YKE A;  2JOG A;  3P71 C;  2YVT A;  4JA7 A;  1S95 A;  2GJU A;  1S70 A;  2WDD A;  3DW8 C;  1V73 A;  3ZU0 A;  5DNY A;  5B8I A;  3N5U A;  4DT2 A;  1IT6 A;  4V0X A;  1M63 A;  2O8G A;  1OID A;  1S8E A;  1HO5 A;  3K7V C;  1HP1 A;  4V0W A;  3IB8 A;  1G5B A;  5IOH A;  4M0V A;  1OIE A;  3FLO A;  4O43 A;  4ORC A;  2IE3 C;  2NXF A;  2ZBM A;  5EQV A;  2QFP A;  3PSN A;  3T1I A;  3DSC A;  3E0J A;  1T70 A;  3IVE A;  2ZO9 B;  2HY1 A;  1SU1 A;  4TUI A;  4H1Y P;  1HPU A;  1II7 A;  4MP0 A;  3H60 A;  5JPF A;  3K7W C;  4FBK A;  1NNW A;  2WDF A;  2NYM C;  2Q8U A;  3EGH A;  2IAE C;  3H63 A;  1AUI A;  4IYP C;  3QG5 C;  4DHL A;  4UT3 A;  3KBP A;  1QHW A;  3QFM A;  3QFN A;  1T71 A;  1XZW A;  2WDE A;  2XMO A;  2KKN A;  3DSD A;  3ICF A;  4OR9 A;  3RQZ A;  2DFJ A;  2YEQ A;  5F3W A;  1TCO A;  3C9F A;  3FGA C;  4DSY A;  4B2O A;  4HD0 A;  4I5N C;  2R17 A;  2HYO A;  3JYF A;  2BCD A;  1Z2W A;  1KBP A;  1OI8 A;  4H2B A;  1UTE A;  4KKZ A;  2IE4 C;  2Z1A A;  3H67 A;  4J6O A;  2CV9 A;  4UT3 B;  4WWL A;  4FBW A;  1QFC A;  4Q7F A;  3RL3 A;  2ZOA A;  2HYP A;  4UT2 A;  2NPP C;  5JPE A;  3V4Y A;  1UF3 A;  2BDX A;  5C1V A;  1WAO 1;  2AHD A;  2P6B A;  3IB7 A;  3QFK A;  4O24 A;  5JJT A;  3EGG A;  4UWQ A;  4IL1 A;  1XM7 A;  1Z2X A;  2QFR A;  4ZVZ A;  1USH A;  2NYL C;  3TGH A;  1S3L A;  3H64 A;  4LTY A;  3H61 A;  3AUZ A;  2A22 A;  4F0Z A;  4H2G A;  3PSO A;  3QFO A;  4O4K A;  3AV0 A;  4JA9 A;  2DXL A;  2WDC A;  2Z06 A;  4TUG A;  1U32 A;  2O8A A;  4XPN A;  3CK2 A;  3GVE A;  4O5G A;  3H66 A;  4FCX A;  1FJM A;  5GTU A;  3THN A;  4MOV A;  4ZX2 A;  3HVQ A;  4H2I A;  5HPE A;  4H2F A;  1JK7 A;  3E7A A;  3D03 A;  4I5L C;  4V0V A;  1S3M A;  3H62 B;  2USH A;  2DXN A;  5J28 A;  4LAC C;  3ZTV A;  2Z72 A;  4H1S A;  4NZV A;  4ORB A;  3RL5 A;  4G9J A;  4LU9 A;  3C5W C;  4ORA A;  2BQ8 X;  4FBQ A;  2QJC A;  1W24 A;  1WAR A;  3H68 A;  3LL8 A;  1MF8 A;  3IVD A;  3THO B;  4KBP A;  1S3N A;  3H69 A;  5INB A;  3RL4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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