4I5NC

Structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
DEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
molecule tags Hydrolase/toxin
source organism Homo sapiens
total genus 104
structure length 293
sequence length 293
chains with identical sequence F
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4i5nC00
3ICFA 4TUIA 1T70A 2NYMC 4FBKA 4V0XA 3IB8A 1II7A 3KBPA 4H1YP 4O5GA 2HY1A 4O4KA 1OI8A 1IT6A 4H2GA 3V4YA 3CK2A 1WAO1 3IVDA 4DT2A 1S95A 5JPFA 3LL8A 5F3WA 3THNA 4MOVA 3EGGA 2WDEA 1JK7A 1S3LA 2HYOA 3DW8C 2Z72A 5C1VA 2Z06A 4Q7FA 3RL3A 3T1IA 3QFOA 3DSCA 4ORBA 3H61A 3QFKA 1HP1A 3THOB 3C9FA 2WDDA 3GVEA 3AUZA 4JA9A 5IOHA 3TGHA 2QFPA 2USHA 4ORCA 4YKEA 2NXFA 2ZBMA 2DFJA 1T71A 1QFCA 4IL1A 1KBPA 4MOYA 4OR9A 4UT2A 4XPNA 3H60A 4NZVA 1Z2XA 1AUIA 2CV9A 3C5WC 5B8IA 2HYPA 2O8GA 2Q8UA 4B2OA 4FBQA 1S3NA 3E7AA 4LU9A 3H62B 3H66A 1W24A 1M63A 4O43A 1SU1A 2BQ8X 3H68A 3IB7A 3K7VC 1USHA 5JPEA 1Z2WA 4FCXA 2IE4C 4LACC 2R17A 4O24A 3RQZA 1UF3A 2O8AA 4JA7A 3H64A 1FJMA 4V0WA 4IYPC 2YVTA 1UTEA 3P71C 1S70A 3ZTVA 5DNYA 2P6BA 3RL5A 4FBWA 2Z1AA 3JYFA 3PSOA 2NPPC 2GJUA 3H67A 4H2IA 2KKNA 1TCOA 2BCDA 1U32A 3FGAC 4HD0A 4MP0A 3ZU0A 3H69A 4H2FA 2QJCA 3RL4A 1NNWA 1WARA 3E7BA 1V73A 4TUGA 3PSNA 1OIEA 2A22A 4ZVZA 4DSYA 5HPEA 2XMOA 4WWLA 1QHWA 2WDCA 4I5NC 3DSDA 2QFRA 5EQVA 3K7WC 4ZX2A 1XM7A 4UWQA 3IVEA 4LTYA 2AHDA 4M0VA 4V0VA 5JJTA 1MF8A 4DHLA 2NYLC 4J6OA 3H63A 3N5UA 5GTUA 1HPUA 4ORAA 4G9JA 3EGHA 3QFMA 3QFNA 4KBPA 3HVQA 4H1SA 2IAEC 4H2BA 3QG5C 1OIDA 2WDFA 1G5BA 3AV0A 1S3MA 2BDXA 1XZWA 4I5LC 1S8EA 5INBA 4UT3B 2JOGA 1HO5A 5J28A 4F0ZA 4UT3A 2IE3C 4KKZA
chains in the Genus database with same CATH superfamily
3ICFA 4TUIA 1T70A 2NYMC 4FBKA 4V0XA 3IB8A 1II7A 3KBPA 4H1YP 4O5GA 2HY1A 4O4KA 1OI8A 1IT6A 4H2GA 3V4YA 3CK2A 1WAO1 3IVDA 4DT2A 1S95A 5JPFA 3LL8A 5F3WA 3THNA 4MOVA 2DXLA 3EGGA 2WDEA 1JK7A 1S3LA 2HYOA 3DW8C 2Z72A 5C1VA 2Z06A 4Q7FA 3RL3A 3T1IA 3QFOA 3DSCA 4ORBA 3H61A 3QFKA 1HP1A 3THOB 3C9FA 2WDDA 3GVEA 3AUZA 4JA9A 5IOHA 3TGHA 2QFPA 2USHA 4ORCA 4YKEA 2NXFA 2ZBMA 2DFJA 1T71A 1QFCA 3FLOA 1KBPA 4IL1A 4MOYA 4OR9A 4UT2A 3H60A 4NZVA 1Z2XA 1AUIA 2CV9A 3C5WC 4XPNA 2HYPA 2O8GA 2Q8UA 4B2OA 5B8IA 4FBQA 1S3NA 3E7AA 4LU9A 3H62B 3H66A 1W24A 1M63A 4O43A 1SU1A 2BQ8X 3H68A 3IB7A 3K7VC 1USHA 5JPEA 1Z2WA 4FCXA 2IE4C 4LACC 2R17A 3E0JA 2ZO9B 4O24A 3RQZA 1UF3A 2YEQA 2O8AA 4JA7A 3H64A 1FJMA 4V0WA 4IYPC 2YVTA 1UTEA 3P71C 1S70A 3ZTVA 5DNYA 2P6BA 3RL5A 4FBWA 2Z1AA 2DXNA 3JYFA 3PSOA 2NPPC 2GJUA 3H67A 4H2IA 2KKNA 1TCOA 2BCDA 1U32A 3FGAC 4HD0A 4MP0A 3ZU0A 3H69A 4H2FA 2QJCA 3RL4A 1NNWA 1WARA 3E7BA 1V73A 4TUGA 3PSNA 1OIEA 2A22A 2ZOAA 4ZVZA 4DSYA 2XMOA 5HPEA 4WWLA 1QHWA 2WDCA 4I5NC 3DSDA 2QFRA 5EQVA 3K7WC 4ZX2A 1XM7A 4UWQA 3IVEA 4LTYA 2AHDA 4M0VA 4V0VA 5JJTA 1MF8A 4DHLA 2NYLC 4J6OA 3H63A 3N5UA 5GTUA 1HPUA 3D03A 4ORAA 4G9JA 3EGHA 3QFMA 3QFNA 4KBPA 3HVQA 4H1SA 2IAEC 4H2BA 3QG5C 1OIDA 2WDFA 1G5BA 3AV0A 1S3MA 2BDXA 1XZWA 4I5LC 1S8EA 5INBA 4UT3B 2JOGA 1HO5A 5J28A 4F0ZA 4UT3A 2IE3C 4KKZA
chains in the Genus database with same CATH topology
3ICFA 4TUIA 1T70A 2NYMC 4FBKA 4V0XA 3IB8A 1II7A 3KBPA 4H1YP 4O5GA 2HY1A 4O4KA 1OI8A 1IT6A 4H2GA 3V4YA 3CK2A 1WAO1 3IVDA 4DT2A 1S95A 5JPFA 3LL8A 5F3WA 3THNA 4MOVA 2DXLA 3EGGA 2WDEA 1JK7A 1S3LA 2HYOA 3DW8C 2Z72A 5C1VA 2Z06A 4Q7FA 3RL3A 3T1IA 3QFOA 3DSCA 4ORBA 3H61A 3QFKA 1HP1A 3THOB 3C9FA 2WDDA 3GVEA 3AUZA 4JA9A 5IOHA 3TGHA 2QFPA 2USHA 4ORCA 4YKEA 2NXFA 2ZBMA 2DFJA 1T71A 1QFCA 3FLOA 1KBPA 4IL1A 4MOYA 4OR9A 4UT2A 3H60A 4NZVA 1Z2XA 1AUIA 2CV9A 3C5WC 4XPNA 2HYPA 2O8GA 2Q8UA 4B2OA 5B8IA 4FBQA 1S3NA 3E7AA 4LU9A 3H62B 3H66A 1W24A 1M63A 4O43A 1SU1A 2BQ8X 3H68A 3IB7A 3K7VC 1USHA 5JPEA 1Z2WA 4FCXA 2IE4C 4LACC 2R17A 3E0JA 2ZO9B 4O24A 3RQZA 1UF3A 2YEQA 2O8AA 4JA7A 3H64A 1FJMA 4V0WA 4IYPC 2YVTA 1UTEA 3P71C 1S70A 3ZTVA 5DNYA 2P6BA 3RL5A 4FBWA 2Z1AA 2DXNA 3JYFA 3PSOA 2NPPC 2GJUA 3H67A 4H2IA 2KKNA 1TCOA 2BCDA 1U32A 3FGAC 4HD0A 4MP0A 3ZU0A 3H69A 4H2FA 2QJCA 3RL4A 1NNWA 1WARA 3E7BA 1V73A 4TUGA 3PSNA 1OIEA 2A22A 2ZOAA 4ZVZA 4DSYA 2XMOA 5HPEA 4WWLA 1QHWA 2WDCA 4I5NC 3DSDA 2QFRA 5EQVA 3K7WC 4ZX2A 1XM7A 4UWQA 3IVEA 4LTYA 2AHDA 4M0VA 4V0VA 5JJTA 1MF8A 4DHLA 2NYLC 4J6OA 3H63A 3N5UA 5GTUA 1HPUA 3D03A 4ORAA 4G9JA 3EGHA 3QFMA 3QFNA 4KBPA 3HVQA 4H1SA 2IAEC 4H2BA 3QG5C 1OIDA 2WDFA 1G5BA 3AV0A 1S3MA 2BDXA 1XZWA 4I5LC 1S8EA 5INBA 4UT3B 2JOGA 1HO5A 5J28A 4F0ZA 4UT3A 2IE3C 4KKZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ICF A;  4TUI A;  1T70 A;  2NYM C;  4FBK A;  4V0X A;  3IB8 A;  1II7 A;  3KBP A;  4H1Y P;  4O5G A;  2HY1 A;  4O4K A;  1OI8 A;  1IT6 A;  4H2G A;  3V4Y A;  3CK2 A;  1WAO 1;  3IVD A;  4DT2 A;  1S95 A;  5JPF A;  3LL8 A;  5F3W A;  3THN A;  4MOV A;  3EGG A;  2WDE A;  1JK7 A;  1S3L A;  2HYO A;  3DW8 C;  2Z72 A;  5C1V A;  2Z06 A;  4Q7F A;  3RL3 A;  3T1I A;  3QFO A;  3DSC A;  4ORB A;  3H61 A;  3QFK A;  1HP1 A;  3THO B;  3C9F A;  2WDD A;  3GVE A;  3AUZ A;  4JA9 A;  5IOH A;  3TGH A;  2QFP A;  2USH A;  4ORC A;  4YKE A;  2NXF A;  2ZBM A;  2DFJ A;  1T71 A;  1QFC A;  4IL1 A;  1KBP A;  4MOY A;  4OR9 A;  4UT2 A;  4XPN A;  3H60 A;  4NZV A;  1Z2X A;  1AUI A;  2CV9 A;  3C5W C;  5B8I A;  2HYP A;  2O8G A;  2Q8U A;  4B2O A;  4FBQ A;  1S3N A;  3E7A A;  4LU9 A;  3H62 B;  3H66 A;  1W24 A;  1M63 A;  4O43 A;  1SU1 A;  2BQ8 X;  3H68 A;  3IB7 A;  3K7V C;  1USH A;  5JPE A;  1Z2W A;  4FCX A;  2IE4 C;  4LAC C;  2R17 A;  4O24 A;  3RQZ A;  1UF3 A;  2O8A A;  4JA7 A;  3H64 A;  1FJM A;  4V0W A;  4IYP C;  2YVT A;  1UTE A;  3P71 C;  1S70 A;  3ZTV A;  5DNY A;  2P6B A;  3RL5 A;  4FBW A;  2Z1A A;  3JYF A;  3PSO A;  2NPP C;  2GJU A;  3H67 A;  4H2I A;  2KKN A;  1TCO A;  2BCD A;  1U32 A;  3FGA C;  4HD0 A;  4MP0 A;  3ZU0 A;  3H69 A;  4H2F A;  2QJC A;  3RL4 A;  1NNW A;  1WAR A;  3E7B A;  1V73 A;  4TUG A;  3PSN A;  1OIE A;  2A22 A;  4ZVZ A;  4DSY A;  5HPE A;  2XMO A;  4WWL A;  1QHW A;  2WDC A;  4I5N C;  3DSD A;  2QFR A;  5EQV A;  3K7W C;  4ZX2 A;  1XM7 A;  4UWQ A;  3IVE A;  4LTY A;  2AHD A;  4M0V A;  4V0V A;  5JJT A;  1MF8 A;  4DHL A;  2NYL C;  4J6O A;  3H63 A;  3N5U A;  5GTU A;  1HPU A;  4ORA A;  4G9J A;  3EGH A;  3QFM A;  3QFN A;  4KBP A;  3HVQ A;  4H1S A;  2IAE C;  4H2B A;  3QG5 C;  1OID A;  2WDF A;  1G5B A;  3AV0 A;  1S3M A;  2BDX A;  1XZW A;  4I5L C;  1S8E A;  5INB A;  4UT3 B;  2JOG A;  1HO5 A;  5J28 A;  4F0Z A;  4UT3 A;  2IE3 C;  4KKZ A; 
#chains in the Genus database with same CATH topology
 3ICF A;  4TUI A;  1T70 A;  2NYM C;  4FBK A;  4V0X A;  3IB8 A;  1II7 A;  3KBP A;  4H1Y P;  4O5G A;  2HY1 A;  4O4K A;  1OI8 A;  1IT6 A;  4H2G A;  3V4Y A;  3CK2 A;  1WAO 1;  3IVD A;  4DT2 A;  1S95 A;  5JPF A;  3LL8 A;  5F3W A;  3THN A;  4MOV A;  2DXL A;  3EGG A;  2WDE A;  1JK7 A;  1S3L A;  2HYO A;  3DW8 C;  2Z72 A;  5C1V A;  2Z06 A;  4Q7F A;  3RL3 A;  3T1I A;  3QFO A;  3DSC A;  4ORB A;  3H61 A;  3QFK A;  1HP1 A;  3THO B;  3C9F A;  2WDD A;  3GVE A;  3AUZ A;  4JA9 A;  5IOH A;  3TGH A;  2QFP A;  2USH A;  4ORC A;  4YKE A;  2NXF A;  2ZBM A;  2DFJ A;  1T71 A;  1QFC A;  3FLO A;  1KBP A;  4IL1 A;  4MOY A;  4OR9 A;  4UT2 A;  3H60 A;  4NZV A;  1Z2X A;  1AUI A;  2CV9 A;  3C5W C;  4XPN A;  2HYP A;  2O8G A;  2Q8U A;  4B2O A;  5B8I A;  4FBQ A;  1S3N A;  3E7A A;  4LU9 A;  3H62 B;  3H66 A;  1W24 A;  1M63 A;  4O43 A;  1SU1 A;  2BQ8 X;  3H68 A;  3IB7 A;  3K7V C;  1USH A;  5JPE A;  1Z2W A;  4FCX A;  2IE4 C;  4LAC C;  2R17 A;  3E0J A;  2ZO9 B;  4O24 A;  3RQZ A;  1UF3 A;  2YEQ A;  2O8A A;  4JA7 A;  3H64 A;  1FJM A;  4V0W A;  4IYP C;  2YVT A;  1UTE A;  3P71 C;  1S70 A;  3ZTV A;  5DNY A;  2P6B A;  3RL5 A;  4FBW A;  2Z1A A;  2DXN A;  3JYF A;  3PSO A;  2NPP C;  2GJU A;  3H67 A;  4H2I A;  2KKN A;  1TCO A;  2BCD A;  1U32 A;  3FGA C;  4HD0 A;  4MP0 A;  3ZU0 A;  3H69 A;  4H2F A;  2QJC A;  3RL4 A;  1NNW A;  1WAR A;  3E7B A;  1V73 A;  4TUG A;  3PSN A;  1OIE A;  2A22 A;  2ZOA A;  4ZVZ A;  4DSY A;  2XMO A;  5HPE A;  4WWL A;  1QHW A;  2WDC A;  4I5N C;  3DSD A;  2QFR A;  5EQV A;  3K7W C;  4ZX2 A;  1XM7 A;  4UWQ A;  3IVE A;  4LTY A;  2AHD A;  4M0V A;  4V0V A;  5JJT A;  1MF8 A;  4DHL A;  2NYL C;  4J6O A;  3H63 A;  3N5U A;  5GTU A;  1HPU A;  3D03 A;  4ORA A;  4G9J A;  3EGH A;  3QFM A;  3QFN A;  4KBP A;  3HVQ A;  4H1S A;  2IAE C;  4H2B A;  3QG5 C;  1OID A;  2WDF A;  1G5B A;  3AV0 A;  1S3M A;  2BDX A;  1XZW A;  4I5L C;  1S8E A;  5INB A;  4UT3 B;  2JOG A;  1HO5 A;  5J28 A;  4F0Z A;  4UT3 A;  2IE3 C;  4KKZ A; 
#chains in the Genus database with same CATH homology
 3ICF A;  4TUI A;  1T70 A;  2NYM C;  4FBK A;  4V0X A;  3IB8 A;  1II7 A;  3KBP A;  4H1Y P;  4O5G A;  2HY1 A;  4O4K A;  1OI8 A;  1IT6 A;  4H2G A;  3V4Y A;  3CK2 A;  1WAO 1;  3IVD A;  4DT2 A;  1S95 A;  5JPF A;  3LL8 A;  5F3W A;  3THN A;  4MOV A;  2DXL A;  3EGG A;  2WDE A;  1JK7 A;  1S3L A;  2HYO A;  3DW8 C;  2Z72 A;  5C1V A;  2Z06 A;  4Q7F A;  3RL3 A;  3T1I A;  3QFO A;  3DSC A;  4ORB A;  3H61 A;  3QFK A;  1HP1 A;  3THO B;  3C9F A;  2WDD A;  3GVE A;  3AUZ A;  4JA9 A;  5IOH A;  3TGH A;  2QFP A;  2USH A;  4ORC A;  4YKE A;  2NXF A;  2ZBM A;  2DFJ A;  1T71 A;  1QFC A;  3FLO A;  1KBP A;  4IL1 A;  4MOY A;  4OR9 A;  4UT2 A;  3H60 A;  4NZV A;  1Z2X A;  1AUI A;  2CV9 A;  3C5W C;  4XPN A;  2HYP A;  2O8G A;  2Q8U A;  4B2O A;  5B8I A;  4FBQ A;  1S3N A;  3E7A A;  4LU9 A;  3H62 B;  3H66 A;  1W24 A;  1M63 A;  4O43 A;  1SU1 A;  2BQ8 X;  3H68 A;  3IB7 A;  3K7V C;  1USH A;  5JPE A;  1Z2W A;  4FCX A;  2IE4 C;  4LAC C;  2R17 A;  3E0J A;  2ZO9 B;  4O24 A;  3RQZ A;  1UF3 A;  2YEQ A;  2O8A A;  4JA7 A;  3H64 A;  1FJM A;  4V0W A;  4IYP C;  2YVT A;  1UTE A;  3P71 C;  1S70 A;  3ZTV A;  5DNY A;  2P6B A;  3RL5 A;  4FBW A;  2Z1A A;  2DXN A;  3JYF A;  3PSO A;  2NPP C;  2GJU A;  3H67 A;  4H2I A;  2KKN A;  1TCO A;  2BCD A;  1U32 A;  3FGA C;  4HD0 A;  4MP0 A;  3ZU0 A;  3H69 A;  4H2F A;  2QJC A;  3RL4 A;  1NNW A;  1WAR A;  3E7B A;  1V73 A;  4TUG A;  3PSN A;  1OIE A;  2A22 A;  2ZOA A;  4ZVZ A;  4DSY A;  2XMO A;  5HPE A;  4WWL A;  1QHW A;  2WDC A;  4I5N C;  3DSD A;  2QFR A;  5EQV A;  3K7W C;  4ZX2 A;  1XM7 A;  4UWQ A;  3IVE A;  4LTY A;  2AHD A;  4M0V A;  4V0V A;  5JJT A;  1MF8 A;  4DHL A;  2NYL C;  4J6O A;  3H63 A;  3N5U A;  5GTU A;  1HPU A;  3D03 A;  4ORA A;  4G9J A;  3EGH A;  3QFM A;  3QFN A;  4KBP A;  3HVQ A;  4H1S A;  2IAE C;  4H2B A;  3QG5 C;  1OID A;  2WDF A;  1G5B A;  3AV0 A;  1S3M A;  2BDX A;  1XZW A;  4I5L C;  1S8E A;  5INB A;  4UT3 B;  2JOG A;  1HO5 A;  5J28 A;  4F0Z A;  4UT3 A;  2IE3 C;  4KKZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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