4X6AL

Crystal structure of yeast rna polymerase ii encountering oxidative cyclopurine dna lesions
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
pubmed doi rcsb
molecule tags Transcription/dna
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 1
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2014-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 4x6aL00
1WCML 2R7ZL 3S17L 3S15L 1TWFL 3H3VM 3GTKL 4C3JL 3GTQL 4C3HL 4X6AL 3GTLL 3GTJL 3S16L 2JA7L 2E2HL 4A3CL 5FJ8L 2B63L 2NVYL 5M5YL 4A93L 3H0GL 3GTGL 4A3LL 1SFOL 4A3EL 2VUML 1I50L 4A3BL 3HOYL 1TWGL 4BY7L 2WB1P 2E2IL 2PMZP 4C3IL 4A3JL 3S2DL 3GTPL 3FKIL 1I6HL 1TWAL 4BY1L 3S1QL 4A3GL 4BBRL 4A3DL 5FLML 5M3ML 4BBSL 2WAQP 4C2M1 3HOWL 4QIWP 1TWHL 3K7AL 4Y7NL 2NVXL 2JA8L 3S1NL 3PO3L 5IYCL 3I4NL 5M5XL 2NVQL 3S1ML 1Y1WL 1K83L 2JA6L 3S1RL 4A3ML 5C4JL 5M3FL 2JA5L 3HOUL 3M4OL 5C44L 5IP9L 3RZOL 2E2JL 5IYDL 4A3IL 2R93L 4A3FL 2NVTL 3S14L 3GTOL 2Y0SP 5IP7L 3CQZL 4BXXL 3M3YL 1R9TL 3HOZL 3GTML 3I4ML 5C3EL 4Y52L 1I3QL 5M5WL 3S2HL 5C4XL 3HOXL 3HKZP 4AYBP 1TWCL 3RZDL 3PO2L 5IYBL 1Y1VL 2YU9L 3HOVL 4A3KL 2R92L
chains in the Genus database with same CATH superfamily
3PL5A 3J7Z1 3KYXA 1TWFL 1H7VA 1FHHA 4C3JL 4AHWA 3RZTA 2B5ID 2HR5A 4POGA 5JVG1 2JA7L 2E2HL 2B63L 1P7PA 2NVYL 5M5YL 4A3LL 1SFOL 1NXGA 1T9QA 4JAGA 2O5JD 4JADA 1PFYA 4G6BA 2PMZP 2Z3QB 3NFPI 2VL6A 4C3IL 3FKIL 4BY1L 3S1QL 3H99A 5M3ML 3P2AA 2WAQP 5MGNA 3K7AL 2NVXL 2JA8L 3S1NL 1RYTA 2NVQL 1IW7D 2A69D 1QQTA 2DSXA 3HJYB 1SMWA 2JA5L 1FHMA 5AN9H 4YWLA 4YWMA 1DX8A 4LHNA 2A6ED 3H9BA 1VZIA 3RZOL 2E2JL 3H97A 5RXNA 4B8CD 2APOB 3S14L 1ODHA 2XJPA 1S2ZA 2GMGA 4XXBB 3LNLA 3CQZL 1CADA 3HOZL 1JYBA 4AI0A 4Y52L 2XJUA 1I3QL 3S2HL 5GAHc 4K9FA 5C4XL 3PWFA 3RYGA 3VPBE 2A68D 3LWPB 3ZG6A 2M4YA 1YK5A 3LWRB 1B2OA 5IYBL 2V0FA 1R0GA 3HOVL 4AI3A 2R92L 1IRNA 4ME3A 5MF6A 1PZXA 4C3HL 2XJVA 2ZIXA 3GTJL 4U671 5FJ8L 3H0GL 2Z3RB 3LWVB 3SS2A 2AQCA 4A3EL 2VUML 5GADc 1TWGL 5K2ME 4AR6A 2E2IL 1B71A 4AHYA 2PSMC 2ERSA 1QYBA 3HAXC 1I6HL 3IU3I 2JI2A 1TWAL 2C6BA 5EINC 5DM61 1YUXA 5IY0A 1R0JA 4Y7NL 3PO3L 5IYCL 2XJSA 5GAEc 4AR4A 1LKOA 1PFWA 5AI2A 3S1RL 5JVH1 2L0ZA 3PIO1 5M3FL 3HOUL 2PVEA 1NNQA 2K2DA 1RWDA 2J9UB 5AI3A 2XJRA 2C6AA 3GTOL 5IP7L 3PKIA 1YK4A 4BXXL 4RXNA 1SMUA 4AR5A 5MFPA 5C3EL 1S24A 3KYVA 3HKZP 1DVBA 1BRFA 3KYUA 2KKDA 4XGHA 1BQ9A 3H9CA 1RYQA 1B13A 1VCXA 2JI3A 1WCML 1YV1A 5GAGc 3S15L 5DM71 3GTKL 3GTQL 2XJTA 4E6YA 2CKCA 4LHLA 3GTLL 3S16L 4TVMA 1OWBA 5MLC3 4A93L 3GTGL 1I50L 3HOYL 3PIP1 2WB1P 2M4VA 1RDGA 4A3JL 4ZN3B 4AHXA 1ZRPA 2M6PA 3PZAA 4AI1A 4A3GL 4A3DL 1B2JA 5FLML 4GS7D 5EIOC 1T9PA 1IROA 4C2M1 2RFKB 3HOWL 1TWHL 3PKJA 2PPTA 5M5XL 3S1ML 1NXEA 1OWCA 2PYAA 4V196 4JAFA 3WWLA 2MS3A 1CAAA 5IYDL 1BQ8A 4AR3A 4AHZA 2Y0SP 1IU6A 2HVYC 4WFN1 1R0HA 2RDVA 3LPEB 1R0IA 3WWNB 3GTML 8RXNA 6RXNA 5M5WL 1RDVA 2AUSB 4AYBP 3RZDL 3PO2L 3QVDA 1Y1VL 2PVXA 2YU9L 1YUZA 4A3KL 3HJWB 2R7ZL 3S17L 3H3VM 3P8BA 3RZ6A 5MFZA 4X6AL 1E8JA 3LWQB 3FDJA 4A3CL 2XJQA 3MSUA 4TPUA 1IU5A 2ERJA 4A3BL 1WJVA 4BY7L 3J7Y1 2A6HD 1PFVA 2NYDA 5H1Sc 3MQKB 3S2DL 2BE5D 3GTPL 1SMMA 1T9OA 1LKPA 1BE7A 2AYJA 4BBRL 3B0AB 1VZGA 4BBSL 1R0FA 2LCQA 3KYWA 4AI2A 4QIWP 3B08B 7RXNA 3MPSA 3I4NL 1QCVA 1Y1WL 1K83L 2JA6L 3JR7A 4A3ML 1S30A 5C4JL 1Z92B 4JAEA 3QQCE 5C44L 2CR8A 3M4OL 2QL0A 5IP9L 2M6OA 1RB9A 3K35A 4POFA 3A44A 4A3IL 2R93L 4A3FL 2CKAA 2NVTL 1BFYA 2H12A 3KYYA 1C09A 1F4LA 4UY81 1VZHA 1PFUA 3M3YL 1R9TL 4ZN1B 3LWOB 3I4ML 2V3BB 2EY4E 2KN9A 3HOXL 2V0EA 1TWCL 1LKMA 1LTLA 2JI1A
chains in the Genus database with same CATH topology
1WCML 2R7ZL 3S17L 3S15L 1TWFL 3H3VM 3GTKL 4C3JL 3GTQL 4C3HL 4X6AL 3GTLL 3GTJL 3S16L 2JA7L 2E2HL 4A3CL 5FJ8L 2B63L 2NVYL 5M5YL 4A93L 3H0GL 3GTGL 4A3LL 1SFOL 4A3EL 2VUML 1I50L 4A3BL 3HOYL 1TWGL 4BY7L 2WB1P 2E2IL 2PMZP 4C3IL 4A3JL 3S2DL 3GTPL 3FKIL 1I6HL 1TWAL 4BY1L 3S1QL 4A3GL 4BBRL 4A3DL 5FLML 5M3ML 4BBSL 2WAQP 4C2M1 3HOWL 4QIWP 1TWHL 3K7AL 4Y7NL 2NVXL 2JA8L 3S1NL 3PO3L 5IYCL 3I4NL 5M5XL 2NVQL 3S1ML 1Y1WL 1K83L 2JA6L 3S1RL 4A3ML 5C4JL 5M3FL 2JA5L 3HOUL 3M4OL 5C44L 5IP9L 3RZOL 2E2JL 5IYDL 4A3IL 2R93L 4A3FL 2NVTL 3S14L 3GTOL 2Y0SP 5IP7L 3CQZL 4BXXL 3M3YL 1R9TL 3HOZL 3GTML 3I4ML 5C3EL 4Y52L 1I3QL 5M5WL 3S2HL 5C4XL 3HOXL 3HKZP 4AYBP 1TWCL 3RZDL 3PO2L 5IYBL 1Y1VL 2YU9L 3HOVL 4A3KL 2R92L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WCM L;  2R7Z L;  3S17 L;  3S15 L;  1TWF L;  3H3V M;  3GTK L;  4C3J L;  3GTQ L;  4C3H L;  4X6A L;  3GTL L;  3GTJ L;  3S16 L;  2JA7 L;  2E2H L;  4A3C L;  5FJ8 L;  2B63 L;  2NVY L;  5M5Y L;  4A93 L;  3H0G L;  3GTG L;  4A3L L;  1SFO L;  4A3E L;  2VUM L;  1I50 L;  4A3B L;  3HOY L;  1TWG L;  4BY7 L;  2WB1 P;  2E2I L;  2PMZ P;  4C3I L;  4A3J L;  3S2D L;  3GTP L;  3FKI L;  1I6H L;  1TWA L;  4BY1 L;  3S1Q L;  4A3G L;  4BBR L;  4A3D L;  5FLM L;  5M3M L;  4BBS L;  2WAQ P;  4C2M 1;  3HOW L;  4QIW P;  1TWH L;  3K7A L;  4Y7N L;  2NVX L;  2JA8 L;  3S1N L;  3PO3 L;  5IYC L;  3I4N L;  5M5X L;  2NVQ L;  3S1M L;  1Y1W L;  1K83 L;  2JA6 L;  3S1R L;  4A3M L;  5C4J L;  5M3F L;  2JA5 L;  3HOU L;  3M4O L;  5C44 L;  5IP9 L;  3RZO L;  2E2J L;  5IYD L;  4A3I L;  2R93 L;  4A3F L;  2NVT L;  3S14 L;  3GTO L;  2Y0S P;  5IP7 L;  3CQZ L;  4BXX L;  3M3Y L;  1R9T L;  3HOZ L;  3GTM L;  3I4M L;  5C3E L;  4Y52 L;  1I3Q L;  5M5W L;  3S2H L;  5C4X L;  3HOX L;  3HKZ P;  4AYB P;  1TWC L;  3RZD L;  3PO2 L;  5IYB L;  1Y1V L;  2YU9 L;  3HOV L;  4A3K L;  2R92 L; 
#chains in the Genus database with same CATH topology
 3PL5 A;  3J7Z 1;  3KYX A;  1TWF L;  1H7V A;  1FHH A;  4C3J L;  4AHW A;  3RZT A;  2B5I D;  2HR5 A;  4POG A;  5JVG 1;  2JA7 L;  2E2H L;  2B63 L;  1P7P A;  2NVY L;  5M5Y L;  4A3L L;  1SFO L;  1NXG A;  1T9Q A;  4JAG A;  2O5J D;  4JAD A;  1PFY A;  4G6B A;  2PMZ P;  2Z3Q B;  3NFP I;  2VL6 A;  4C3I L;  3FKI L;  4BY1 L;  3S1Q L;  3H99 A;  5M3M L;  3P2A A;  2WAQ P;  5MGN A;  3K7A L;  2NVX L;  2JA8 L;  3S1N L;  1RYT A;  2NVQ L;  1IW7 D;  2A69 D;  1QQT A;  2DSX A;  3HJY B;  1SMW A;  2JA5 L;  1FHM A;  5AN9 H;  4YWL A;  4YWM A;  1DX8 A;  4LHN A;  2A6E D;  3H9B A;  1VZI A;  3RZO L;  2E2J L;  3H97 A;  5RXN A;  4B8C D;  2APO B;  3S14 L;  1ODH A;  2XJP A;  1S2Z A;  2GMG A;  4XXB B;  3LNL A;  3CQZ L;  1CAD A;  3HOZ L;  1JYB A;  4AI0 A;  4Y52 L;  2XJU A;  1I3Q L;  3S2H L;  5GAH c;  4K9F A;  5C4X L;  3PWF A;  3RYG A;  3VPB E;  2A68 D;  3LWP B;  3ZG6 A;  2M4Y A;  1YK5 A;  3LWR B;  1B2O A;  5IYB L;  2V0F A;  1R0G A;  3HOV L;  4AI3 A;  2R92 L;  1IRN A;  4ME3 A;  5MF6 A;  1PZX A;  4C3H L;  2XJV A;  2ZIX A;  3GTJ L;  4U67 1;  5FJ8 L;  3H0G L;  2Z3R B;  3LWV B;  3SS2 A;  2AQC A;  4A3E L;  2VUM L;  5GAD c;  1TWG L;  5K2M E;  4AR6 A;  2E2I L;  1B71 A;  4AHY A;  2PSM C;  2ERS A;  1QYB A;  3HAX C;  1I6H L;  3IU3 I;  2JI2 A;  1TWA L;  2C6B A;  5EIN C;  5DM6 1;  1YUX A;  5IY0 A;  1R0J A;  4Y7N L;  3PO3 L;  5IYC L;  2XJS A;  5GAE c;  4AR4 A;  1LKO A;  1PFW A;  5AI2 A;  3S1R L;  5JVH 1;  2L0Z A;  3PIO 1;  5M3F L;  3HOU L;  2PVE A;  1NNQ A;  2K2D A;  1RWD A;  2J9U B;  5AI3 A;  2XJR A;  2C6A A;  3GTO L;  5IP7 L;  3PKI A;  1YK4 A;  4BXX L;  4RXN A;  1SMU A;  4AR5 A;  5MFP A;  5C3E L;  1S24 A;  3KYV A;  3HKZ P;  1DVB A;  1BRF A;  3KYU A;  2KKD A;  4XGH A;  1BQ9 A;  3H9C A;  1RYQ A;  1B13 A;  1VCX A;  2JI3 A;  1WCM L;  1YV1 A;  5GAG c;  3S15 L;  5DM7 1;  3GTK L;  3GTQ L;  2XJT A;  4E6Y A;  2CKC A;  4LHL A;  3GTL L;  3S16 L;  4TVM A;  1OWB A;  5MLC 3;  4A93 L;  3GTG L;  1I50 L;  3HOY L;  3PIP 1;  2WB1 P;  2M4V A;  1RDG A;  4A3J L;  4ZN3 B;  4AHX A;  1ZRP A;  2M6P A;  3PZA A;  4AI1 A;  4A3G L;  4A3D L;  1B2J A;  5FLM L;  4GS7 D;  5EIO C;  1T9P A;  1IRO A;  4C2M 1;  2RFK B;  3HOW L;  1TWH L;  3PKJ A;  2PPT A;  5M5X L;  3S1M L;  1NXE A;  1OWC A;  2PYA A;  4V19 6;  4JAF A;  3WWL A;  2MS3 A;  1CAA A;  5IYD L;  1BQ8 A;  4AR3 A;  4AHZ A;  2Y0S P;  1IU6 A;  2HVY C;  4WFN 1;  1R0H A;  2RDV A;  3LPE B;  1R0I A;  3WWN B;  3GTM L;  8RXN A;  6RXN A;  5M5W L;  1RDV A;  2AUS B;  4AYB P;  3RZD L;  3PO2 L;  3QVD A;  1Y1V L;  2PVX A;  2YU9 L;  1YUZ A;  4A3K L;  3HJW B;  2R7Z L;  3S17 L;  3H3V M;  3P8B A;  3RZ6 A;  5MFZ A;  4X6A L;  1E8J A;  3LWQ B;  3FDJ A;  4A3C L;  2XJQ A;  3MSU A;  4TPU A;  1IU5 A;  2ERJ A;  4A3B L;  1WJV A;  4BY7 L;  3J7Y 1;  2A6H D;  1PFV A;  2NYD A;  5H1S c;  3MQK B;  3S2D L;  2BE5 D;  3GTP L;  1SMM A;  1T9O A;  1LKP A;  1BE7 A;  2AYJ A;  4BBR L;  3B0A B;  1VZG A;  4BBS L;  1R0F A;  2LCQ A;  3KYW A;  4AI2 A;  4QIW P;  3B08 B;  7RXN A;  3MPS A;  3I4N L;  1QCV A;  1Y1W L;  1K83 L;  2JA6 L;  3JR7 A;  4A3M L;  1S30 A;  5C4J L;  1Z92 B;  4JAE A;  3QQC E;  5C44 L;  2CR8 A;  3M4O L;  2QL0 A;  5IP9 L;  2M6O A;  1RB9 A;  3K35 A;  4POF A;  3A44 A;  4A3I L;  2R93 L;  4A3F L;  2CKA A;  2NVT L;  1BFY A;  2H12 A;  3KYY A;  1C09 A;  1F4L A;  4UY8 1;  1VZH A;  1PFU A;  3M3Y L;  1R9T L;  4ZN1 B;  3LWO B;  3I4M L;  2V3B B;  2EY4 E;  2KN9 A;  3HOX L;  2V0E A;  1TWC L;  1LKM A;  1LTL A;  2JI1 A; 
#chains in the Genus database with same CATH homology
 1WCM L;  2R7Z L;  3S17 L;  3S15 L;  1TWF L;  3H3V M;  3GTK L;  4C3J L;  3GTQ L;  4C3H L;  4X6A L;  3GTL L;  3GTJ L;  3S16 L;  2JA7 L;  2E2H L;  4A3C L;  5FJ8 L;  2B63 L;  2NVY L;  5M5Y L;  4A93 L;  3H0G L;  3GTG L;  4A3L L;  1SFO L;  4A3E L;  2VUM L;  1I50 L;  4A3B L;  3HOY L;  1TWG L;  4BY7 L;  2WB1 P;  2E2I L;  2PMZ P;  4C3I L;  4A3J L;  3S2D L;  3GTP L;  3FKI L;  1I6H L;  1TWA L;  4BY1 L;  3S1Q L;  4A3G L;  4BBR L;  4A3D L;  5FLM L;  5M3M L;  4BBS L;  2WAQ P;  4C2M 1;  3HOW L;  4QIW P;  1TWH L;  3K7A L;  4Y7N L;  2NVX L;  2JA8 L;  3S1N L;  3PO3 L;  5IYC L;  3I4N L;  5M5X L;  2NVQ L;  3S1M L;  1Y1W L;  1K83 L;  2JA6 L;  3S1R L;  4A3M L;  5C4J L;  5M3F L;  2JA5 L;  3HOU L;  3M4O L;  5C44 L;  5IP9 L;  3RZO L;  2E2J L;  5IYD L;  4A3I L;  2R93 L;  4A3F L;  2NVT L;  3S14 L;  3GTO L;  2Y0S P;  5IP7 L;  3CQZ L;  4BXX L;  3M3Y L;  1R9T L;  3HOZ L;  3GTM L;  3I4M L;  5C3E L;  4Y52 L;  1I3Q L;  5M5W L;  3S2H L;  5C4X L;  3HOX L;  3HKZ P;  4AYB P;  1TWC L;  3RZD L;  3PO2 L;  5IYB L;  1Y1V L;  2YU9 L;  3HOV L;  4A3K L;  2R92 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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